EFNA4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. Three transcript variants that encode distinct proteins have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)5.46268097
2translational termination (GO:0006415)5.24107218
3ribosomal small subunit assembly (GO:0000028)4.90911431
4ribosomal small subunit biogenesis (GO:0042274)4.77981935
5translational elongation (GO:0006414)4.65229586
6maturation of SSU-rRNA (GO:0030490)4.34896211
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.33677572
8nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.31467897
9ribosomal large subunit biogenesis (GO:0042273)4.25124813
10protein targeting to ER (GO:0045047)4.22227760
11cotranslational protein targeting to membrane (GO:0006613)4.21704827
12translational initiation (GO:0006413)4.19862780
13cellular protein complex disassembly (GO:0043624)4.08702490
14viral life cycle (GO:0019058)4.08581008
15paraxial mesoderm development (GO:0048339)4.04773796
16establishment of protein localization to endoplasmic reticulum (GO:0072599)3.99298703
17proteasome assembly (GO:0043248)3.95465125
18protein localization to endoplasmic reticulum (GO:0070972)3.88824567
19protein complex disassembly (GO:0043241)3.79577352
20DNA unwinding involved in DNA replication (GO:0006268)3.64102495
21L-serine metabolic process (GO:0006563)3.58320480
22establishment of protein localization to mitochondrial membrane (GO:0090151)3.55240688
23macromolecular complex disassembly (GO:0032984)3.55121184
24regulation of gene silencing by RNA (GO:0060966)3.55005728
25regulation of posttranscriptional gene silencing (GO:0060147)3.55005728
26regulation of gene silencing by miRNA (GO:0060964)3.55005728
27negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.54290491
28formation of translation preinitiation complex (GO:0001731)3.49541933
29mitotic metaphase plate congression (GO:0007080)3.47338527
30pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.40447149
31outer ear morphogenesis (GO:0042473)3.39161375
32notochord development (GO:0030903)3.36265741
33protein localization to kinetochore (GO:0034501)3.34865642
34DNA strand renaturation (GO:0000733)3.34610973
35RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.33288629
36tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.33288629
37ribonucleoprotein complex biogenesis (GO:0022613)3.28338433
38nuclear-transcribed mRNA catabolic process (GO:0000956)3.22948794
39chaperone-mediated protein transport (GO:0072321)3.22687804
40DNA strand elongation involved in DNA replication (GO:0006271)3.21654085
41base-excision repair, AP site formation (GO:0006285)3.19181287
42rRNA modification (GO:0000154)3.17501736
43regulation of retinoic acid receptor signaling pathway (GO:0048385)3.17118153
44kinetochore assembly (GO:0051382)3.14218219
45negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.12651724
46planar cell polarity pathway involved in neural tube closure (GO:0090179)3.12265643
47kinetochore organization (GO:0051383)3.08128307
48mRNA catabolic process (GO:0006402)3.04442762
49DNA replication initiation (GO:0006270)3.03994024
50DNA strand elongation (GO:0022616)3.03836670
51DNA deamination (GO:0045006)3.03481442
52base-excision repair (GO:0006284)3.02383968
53metaphase plate congression (GO:0051310)3.01019462
54regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.99416588
55anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.97427203
56translation (GO:0006412)2.96801740
57spliceosomal snRNP assembly (GO:0000387)2.96720704
58telomere maintenance via semi-conservative replication (GO:0032201)2.93938669
59regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.93826832
60RNA catabolic process (GO:0006401)2.92453177
61regulation of mitochondrial translation (GO:0070129)2.92268124
62spliceosomal complex assembly (GO:0000245)2.91026199
63positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.87985362
64mitotic nuclear envelope disassembly (GO:0007077)2.87533711
65establishment of viral latency (GO:0019043)2.86488353
66DNA replication checkpoint (GO:0000076)2.86228805
67pentose metabolic process (GO:0019321)2.85741128
68negative regulation of ligase activity (GO:0051352)2.85350070
69negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.85350070
70deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.83992369
71pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.82841157
72regulation of hippo signaling (GO:0035330)2.82494511
73pyrimidine nucleotide catabolic process (GO:0006244)2.81970787
74G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.81318027
75protein localization to chromosome, centromeric region (GO:0071459)2.79483894
76pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.79224784
77protein targeting to membrane (GO:0006612)2.78174476
78mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.77772094
79DNA damage response, detection of DNA damage (GO:0042769)2.76554083
80heterochromatin organization (GO:0070828)2.75827189
81replication fork processing (GO:0031297)2.75322319
82transcription from mitochondrial promoter (GO:0006390)2.75036488
83regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.74734173
84negative regulation of RNA splicing (GO:0033119)2.73749164
85rRNA processing (GO:0006364)2.73745294
86DNA replication-dependent nucleosome assembly (GO:0006335)2.72375468
87DNA replication-dependent nucleosome organization (GO:0034723)2.72375468
88mitotic recombination (GO:0006312)2.71961176
89folic acid-containing compound biosynthetic process (GO:0009396)2.71103598
90ncRNA 3-end processing (GO:0043628)2.70843395
91negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.70563741
92DNA ligation (GO:0006266)2.68380469
93epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.67721969
94somatic diversification of immune receptors via somatic mutation (GO:0002566)2.66253182
95somatic hypermutation of immunoglobulin genes (GO:0016446)2.66253182
96negative regulation of cell fate specification (GO:0009996)2.66058682
97chromatin remodeling at centromere (GO:0031055)2.65468679
98serine family amino acid biosynthetic process (GO:0009070)2.65014681
99regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.64594285
100nuclear envelope disassembly (GO:0051081)2.63778101
101membrane disassembly (GO:0030397)2.63778101
102rRNA metabolic process (GO:0016072)2.63390799
103establishment of apical/basal cell polarity (GO:0035089)2.63016404
104mitotic sister chromatid segregation (GO:0000070)2.61945706
105guanosine-containing compound biosynthetic process (GO:1901070)2.60932988
106telomere maintenance via recombination (GO:0000722)2.60433112
107pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.60035182
108mitochondrial RNA metabolic process (GO:0000959)2.59401546
109protein targeting to mitochondrion (GO:0006626)2.58415590
110telomere maintenance via telomere lengthening (GO:0010833)2.58301026
111ventricular cardiac muscle cell development (GO:0055015)2.58259684
112CENP-A containing nucleosome assembly (GO:0034080)2.58185217
113polarized epithelial cell differentiation (GO:0030859)2.57504289
114regulation of sister chromatid cohesion (GO:0007063)2.57324209
115positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.57314898
116mesenchymal cell proliferation (GO:0010463)2.57210772
117regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.56276291
118establishment of chromosome localization (GO:0051303)2.56252241
119regulation of spindle organization (GO:0090224)2.55697185
120peptidyl-arginine omega-N-methylation (GO:0035247)2.54426874
121nucleobase biosynthetic process (GO:0046112)2.51161295
122cochlea morphogenesis (GO:0090103)2.50707499
123RNA splicing, via transesterification reactions (GO:0000375)2.50401899
124DNA replication-independent nucleosome organization (GO:0034724)2.50164141
125DNA replication-independent nucleosome assembly (GO:0006336)2.50164141
126mRNA splicing, via spliceosome (GO:0000398)2.49889213
127RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.49889213
128histone exchange (GO:0043486)2.49548499
129nodal signaling pathway (GO:0038092)2.48555401
130histone arginine methylation (GO:0034969)2.48554521
131sister chromatid segregation (GO:0000819)2.47794548
132establishment of integrated proviral latency (GO:0075713)2.46661617
133cellular component biogenesis (GO:0044085)2.46339968
134ribosome biogenesis (GO:0042254)2.43846836
135pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.43759544
136pattern specification involved in kidney development (GO:0061004)2.43605230
137positive regulation of ligase activity (GO:0051351)2.43299121
138rRNA methylation (GO:0031167)2.43112955
139positive regulation of SMAD protein import into nucleus (GO:0060391)2.40804974
140ribosome assembly (GO:0042255)2.40421798
141lateral sprouting from an epithelium (GO:0060601)2.39286814
142transcription-coupled nucleotide-excision repair (GO:0006283)2.38531748
143hippo signaling (GO:0035329)2.38333082
144negative regulation of chromosome segregation (GO:0051985)2.37749361
145nucleotide-excision repair, DNA gap filling (GO:0006297)2.36719264
146mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.36678253
147lung-associated mesenchyme development (GO:0060484)2.36359803
148mitotic chromosome condensation (GO:0007076)2.35786183

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.18011119
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.40035319
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.89984480
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.85458492
5MYC_19079543_ChIP-ChIP_MESCs_Mouse3.30712022
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.22937485
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.19737077
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.91131297
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.82789076
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.67460983
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.59395944
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.43427463
13XRN2_22483619_ChIP-Seq_HELA_Human2.42165531
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.41563088
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.25423863
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.22074116
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.18372729
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.18173191
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.16439104
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.15259443
21TP63_19390658_ChIP-ChIP_HaCaT_Human2.10040896
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.06954693
23MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.00408666
24GABP_17652178_ChIP-ChIP_JURKAT_Human1.95821674
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.95427115
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.93249148
27AR_21909140_ChIP-Seq_LNCAP_Human1.93060315
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.92620071
29* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.92168908
30ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.91249347
31KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.88998742
32POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.87585330
33* TTF2_22483619_ChIP-Seq_HELA_Human1.87474457
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.86568814
35POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.85691497
36* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.84129329
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.76544555
38KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.74370420
39KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.74370420
40KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.74370420
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.73571844
42PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.68120318
43MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.67794190
44SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.65951534
45NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.65261824
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.61500577
47KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.60036212
48DCP1A_22483619_ChIP-Seq_HELA_Human1.59680689
49E2F1_21310950_ChIP-Seq_MCF-7_Human1.59476756
50* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.54604132
51* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.53055058
52EGR1_19374776_ChIP-ChIP_THP-1_Human1.50049294
53CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.49537381
54POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.46618009
55MYCN_18555785_ChIP-Seq_MESCs_Mouse1.46552877
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41274228
57KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.41234915
58GABP_19822575_ChIP-Seq_HepG2_Human1.40753834
59STAT3_1855785_ChIP-Seq_MESCs_Mouse1.39480388
60VDR_23849224_ChIP-Seq_CD4+_Human1.37833585
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.36997035
62* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.33375790
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.31325464
64CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.31264573
65NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.29221448
66ELK1_19687146_ChIP-ChIP_HELA_Human1.28280015
67* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.28061967
68THAP11_20581084_ChIP-Seq_MESCs_Mouse1.25631275
69SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.25508080
70* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.25198523
71MYC_22102868_ChIP-Seq_BL_Human1.23244983
72KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22466653
73FOXP3_21729870_ChIP-Seq_TREG_Human1.22457402
74HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.21676379
75ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21231666
76SALL1_21062744_ChIP-ChIP_HESCs_Human1.21064393
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.20210586
78E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19573111
79CTCF_18555785_ChIP-Seq_MESCs_Mouse1.18774658
80NANOG_21062744_ChIP-ChIP_HESCs_Human1.18661928
81HIF1A_21447827_ChIP-Seq_MCF-7_Human1.18401131
82ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.18164518
83KDM5A_27292631_Chip-Seq_BREAST_Human1.16656358
84YY1_21170310_ChIP-Seq_MESCs_Mouse1.16472085
85SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.15840159
86ESR1_15608294_ChIP-ChIP_MCF-7_Human1.13534961
87NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.13400582
88TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.11004456
89TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10115688
90NANOG_16153702_ChIP-ChIP_HESCs_Human1.08396759
91* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.08272905
92YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08007633
93CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07095478
94DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.06908517
95BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05202824
96CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04560815
97* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04073437
98PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.03931312
99* FOXP1_21924763_ChIP-Seq_HESCs_Human1.03616078
100ELK1_22589737_ChIP-Seq_MCF10A_Human1.03019424
101PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02432606
102NANOG_18692474_ChIP-Seq_MEFs_Mouse1.01949127
103HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.01380502
104ZNF263_19887448_ChIP-Seq_K562_Human1.00953209
105TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.00557518
106SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.00100981
107CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99750153
108ATF3_27146783_Chip-Seq_COLON_Human0.98307539
109MYC_18940864_ChIP-ChIP_HL60_Human0.97084852
110ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97021613
111* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.96829097
112ELF1_17652178_ChIP-ChIP_JURKAT_Human0.96514944
113TRIM28_21343339_ChIP-Seq_HEK293_Human0.96471354
114CIITA_25753668_ChIP-Seq_RAJI_Human0.95852249
115TET1_21451524_ChIP-Seq_MESCs_Mouse0.94852129
116CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94006842
117IRF1_19129219_ChIP-ChIP_H3396_Human0.92747317
118POU5F1_16518401_ChIP-PET_MESCs_Mouse0.92256623
119FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.92067576
120NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.91955202
121PADI4_21655091_ChIP-ChIP_MCF-7_Human0.91107437
122* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.90987849
123SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.90604145
124STAT6_21828071_ChIP-Seq_BEAS2B_Human0.90220316
125NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.90177230
126* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.88918628
127SOX2_16153702_ChIP-ChIP_HESCs_Human0.88506136

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology3.92902542
2MP0004957_abnormal_blastocyst_morpholog2.71526604
3MP0003705_abnormal_hypodermis_morpholog2.69784056
4MP0003693_abnormal_embryo_hatching2.68319383
5MP0009053_abnormal_anal_canal2.54638992
6MP0000537_abnormal_urethra_morphology2.38262536
7MP0003111_abnormal_nucleus_morphology2.35096412
8MP0003123_paternal_imprinting2.33520520
9MP0002249_abnormal_larynx_morphology2.31055095
10MP0003941_abnormal_skin_development2.26321336
11MP0010094_abnormal_chromosome_stability2.18604898
12MP0003077_abnormal_cell_cycle2.17030859
13MP0000049_abnormal_middle_ear2.16351225
14MP0008260_abnormal_autophagy2.15016508
15MP0008007_abnormal_cellular_replicative2.00462978
16MP0000579_abnormal_nail_morphology2.00154881
17MP0003315_abnormal_perineum_morphology1.98811733
18MP0008932_abnormal_embryonic_tissue1.93283606
19MP0010352_gastrointestinal_tract_polyps1.92282592
20MP0003385_abnormal_body_wall1.91853347
21MP0000566_synostosis1.90112027
22MP0000678_abnormal_parathyroid_gland1.85395968
23MP0003119_abnormal_digestive_system1.81951859
24MP0003942_abnormal_urinary_system1.80512076
25MP0008789_abnormal_olfactory_epithelium1.78842113
26MP0002653_abnormal_ependyma_morphology1.72212207
27MP0009250_abnormal_appendicular_skeleto1.71067517
28MP0003937_abnormal_limbs/digits/tail_de1.70412481
29MP0004133_heterotaxia1.70036666
30MP0000762_abnormal_tongue_morphology1.65881645
31MP0009697_abnormal_copulation1.57242993
32MP0000350_abnormal_cell_proliferation1.56456893
33MP0002085_abnormal_embryonic_tissue1.54989810
34MP0003755_abnormal_palate_morphology1.54555123
35MP0005408_hypopigmentation1.53096498
36MP0005367_renal/urinary_system_phenotyp1.52377063
37MP0000516_abnormal_urinary_system1.52377063
38MP0001293_anophthalmia1.49199301
39MP0003186_abnormal_redox_activity1.49136011
40MP0001730_embryonic_growth_arrest1.47960212
41MP0002796_impaired_skin_barrier1.46677856
42MP0002282_abnormal_trachea_morphology1.45692873
43MP0002084_abnormal_developmental_patter1.45216117
44MP0003567_abnormal_fetal_cardiomyocyte1.40893269
45MP0002098_abnormal_vibrissa_morphology1.40653695
46MP0009379_abnormal_foot_pigmentation1.39999465
47MP0004197_abnormal_fetal_growth/weight/1.38474605
48MP0000428_abnormal_craniofacial_morphol1.38165411
49MP0002932_abnormal_joint_morphology1.38017732
50MP0005275_abnormal_skin_tensile1.37151553
51MP0003890_abnormal_embryonic-extraembry1.36111103
52MP0004264_abnormal_extraembryonic_tissu1.36078414
53MP0001849_ear_inflammation1.35643992
54MP0002111_abnormal_tail_morphology1.35493783
55MP0001697_abnormal_embryo_size1.34381538
56MP0005501_abnormal_skin_physiology1.33210632
57MP0005380_embryogenesis_phenotype1.32747026
58MP0001672_abnormal_embryogenesis/_devel1.32747026
59MP0002233_abnormal_nose_morphology1.32695409
60MP0008058_abnormal_DNA_repair1.32440257
61MP0003121_genomic_imprinting1.32369565
62MP0004272_abnormal_basement_membrane1.32036194
63MP0000647_abnormal_sebaceous_gland1.30932943
64MP0003935_abnormal_craniofacial_develop1.30683735
65MP0008057_abnormal_DNA_replication1.28943793
66MP0002938_white_spotting1.28885630
67MP0005377_hearing/vestibular/ear_phenot1.27251487
68MP0003878_abnormal_ear_physiology1.27251487
69MP0005499_abnormal_olfactory_system1.25246624
70MP0005394_taste/olfaction_phenotype1.25246624
71MP0000432_abnormal_head_morphology1.23669264
72MP0003115_abnormal_respiratory_system1.22603881
73MP0001286_abnormal_eye_development1.22135805
74MP0002234_abnormal_pharynx_morphology1.21841429
75MP0005076_abnormal_cell_differentiation1.20636669
76MP0010234_abnormal_vibrissa_follicle1.15529318
77MP0003938_abnormal_ear_development1.15504685
78MP0002163_abnormal_gland_morphology1.14847554
79MP0003984_embryonic_growth_retardation1.14741069
80MP0006292_abnormal_olfactory_placode1.14145222
81MP0002116_abnormal_craniofacial_bone1.13733316
82MP0002088_abnormal_embryonic_growth/wei1.13380498
83MP0000534_abnormal_ureter_morphology1.12471384
84MP0002086_abnormal_extraembryonic_tissu1.10642438
85MP0009672_abnormal_birth_weight1.09499813
86MP0005623_abnormal_meninges_morphology1.07150951
87MP0000383_abnormal_hair_follicle1.07062105
88MP0000358_abnormal_cell_content/1.04183697
89MP0002080_prenatal_lethality1.04088057
90MP0003806_abnormal_nucleotide_metabolis1.04023212
91MP0006054_spinal_hemorrhage1.03372148
92MP0002132_abnormal_respiratory_system1.03254135
93MP0005023_abnormal_wound_healing1.03056015
94MP0000462_abnormal_digestive_system1.02742682
95MP0005508_abnormal_skeleton_morphology1.01917962
96MP0002160_abnormal_reproductive_system1.00492992
97MP0005058_abnormal_lysosome_morphology0.98893562
98MP0004233_abnormal_muscle_weight0.97974280
99MP0002092_abnormal_eye_morphology0.97776531
100MP0000467_abnormal_esophagus_morphology0.96832158
101MP0003786_premature_aging0.96389896
102MP0002177_abnormal_outer_ear0.95343978
103MP0002697_abnormal_eye_size0.94830973
104MP0000490_abnormal_crypts_of0.93945341
105MP0003718_maternal_effect0.93847412
106MP0002114_abnormal_axial_skeleton0.93025127
107MP0002060_abnormal_skin_morphology0.91570664
108MP0003566_abnormal_cell_adhesion0.90966650
109MP0000313_abnormal_cell_death0.90494425
110MP0002109_abnormal_limb_morphology0.89667247
111MP0003122_maternal_imprinting0.89293607
112MP0002210_abnormal_sex_determination0.89259837
113MP0008995_early_reproductive_senescence0.89237029
114MP0001346_abnormal_lacrimal_gland0.88150614
115MP0006035_abnormal_mitochondrial_morpho0.88058684
116MP0009384_cardiac_valve_regurgitation0.87935610
117MP0003936_abnormal_reproductive_system0.86884750
118MP0008438_abnormal_cutaneous_collagen0.86716446
119MP0010678_abnormal_skin_adnexa0.86030056
120MP0000377_abnormal_hair_follicle0.85264050
121MP0001216_abnormal_epidermal_layer0.83891294
122MP0000163_abnormal_cartilage_morphology0.82791400
123MP0001529_abnormal_vocalization0.82388814
124MP0000733_abnormal_muscle_development0.81974481
125MP0005248_abnormal_Harderian_gland0.81329938
126MP0004019_abnormal_vitamin_homeostasis0.80809755
127MP0003283_abnormal_digestive_organ0.80384226
128MP0003861_abnormal_nervous_system0.78260221
129MP0003136_yellow_coat_color0.76788543
130MP0000427_abnormal_hair_cycle0.75509475
131MP0004858_abnormal_nervous_system0.75128575
132MP0001764_abnormal_homeostasis0.74517121

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.23219429
2Microvesicular hepatic steatosis (HP:0001414)3.36322820
3Abnormality of cells of the erythroid lineage (HP:0012130)3.18276691
4Colon cancer (HP:0003003)3.12844536
5Selective tooth agenesis (HP:0001592)3.12031225
6Concave nail (HP:0001598)3.00112923
7Trismus (HP:0000211)2.99701878
8Abnormal number of erythroid precursors (HP:0012131)2.85782892
9Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.76636755
10Short 4th metacarpal (HP:0010044)2.76636755
11Breast hypoplasia (HP:0003187)2.76221833
12Hypoplastic pelvis (HP:0008839)2.76177282
13Chromosomal breakage induced by crosslinking agents (HP:0003221)2.69869031
14Hyperglycinemia (HP:0002154)2.69086264
15Protrusio acetabuli (HP:0003179)2.65875112
16Atresia of the external auditory canal (HP:0000413)2.64906441
17Macrocytic anemia (HP:0001972)2.61362530
18Abnormality of the aortic arch (HP:0012303)2.57254245
19Aplasia/Hypoplasia of the patella (HP:0006498)2.52736604
20Hemivertebrae (HP:0002937)2.48746511
21Abnormality of the phalanges of the hallux (HP:0010057)2.48371221
22Aplasia/Hypoplasia of the sacrum (HP:0008517)2.43763469
23Stenosis of the external auditory canal (HP:0000402)2.42413071
24Patellar aplasia (HP:0006443)2.42240883
25Type I transferrin isoform profile (HP:0003642)2.41673580
26Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.40969983
27Absent epiphyses (HP:0010577)2.40969983
28Rib fusion (HP:0000902)2.38033966
29Abnormal lung lobation (HP:0002101)2.37641029
30Shawl scrotum (HP:0000049)2.35902636
31Hypoplasia of the capital femoral epiphysis (HP:0003090)2.32259232
32Microglossia (HP:0000171)2.31501492
33Shallow orbits (HP:0000586)2.30638060
34Woolly hair (HP:0002224)2.28571008
35High anterior hairline (HP:0009890)2.26605798
36Pallor (HP:0000980)2.26371350
37Renal duplication (HP:0000075)2.25756100
38Missing ribs (HP:0000921)2.22461601
39Increased hepatocellular lipid droplets (HP:0006565)2.21622912
40Facial cleft (HP:0002006)2.20320247
41Absent radius (HP:0003974)2.17166194
42Lipid accumulation in hepatocytes (HP:0006561)2.15532764
43Abnormal mitochondria in muscle tissue (HP:0008316)2.15292298
44Abnormality of the 4th metacarpal (HP:0010012)2.15234649
45Duplication of thumb phalanx (HP:0009942)2.14859101
46Supernumerary spleens (HP:0009799)2.10152899
47Triphalangeal thumb (HP:0001199)2.09847371
48Sparse eyelashes (HP:0000653)2.09623327
49Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.09591470
50Abnormal protein N-linked glycosylation (HP:0012347)2.09591470
51Abnormal protein glycosylation (HP:0012346)2.09591470
52Abnormal glycosylation (HP:0012345)2.09591470
53Preauricular skin tag (HP:0000384)2.09010957
54Meckel diverticulum (HP:0002245)2.08955467
55Abnormal hemoglobin (HP:0011902)2.08796792
56Hepatocellular necrosis (HP:0001404)2.08302226
57Absent forearm bone (HP:0003953)2.08040575
58Aplasia involving forearm bones (HP:0009822)2.08040575
59Abnormality of the fetal cardiovascular system (HP:0010948)2.07398934
60Abnormal umbilical cord blood vessels (HP:0011403)2.07398934
61Single umbilical artery (HP:0001195)2.07398934
62Median cleft lip (HP:0000161)2.06725882
63Lip pit (HP:0100267)2.06515671
64Hyperglycinuria (HP:0003108)2.06462489
65Partial duplication of the phalanx of hand (HP:0009999)2.06148142
66Irregular epiphyses (HP:0010582)2.05223339
67Abnormal number of incisors (HP:0011064)2.05075450
68Abnormality of the umbilical cord (HP:0010881)2.04098678
69Aplasia/Hypoplasia of the breasts (HP:0010311)2.04024390
70Broad toe (HP:0001837)2.03939965
71Down-sloping shoulders (HP:0200021)2.02707781
7211 pairs of ribs (HP:0000878)2.02500361
73Abnormality of reticulocytes (HP:0004312)1.99402877
74Abnormality of serine family amino acid metabolism (HP:0010894)1.99362196
75Abnormality of glycine metabolism (HP:0010895)1.99362196
76Adrenal hypoplasia (HP:0000835)1.98428659
77Abdominal situs inversus (HP:0003363)1.97478061
78Abnormality of abdominal situs (HP:0011620)1.97478061
79Abnormality of the ileum (HP:0001549)1.97358087
80Mitochondrial inheritance (HP:0001427)1.96515518
81Acute necrotizing encephalopathy (HP:0006965)1.95849801
82Broad distal phalanx of finger (HP:0009836)1.95803963
83Bifid tongue (HP:0010297)1.95639188
84Renal Fanconi syndrome (HP:0001994)1.95054976
85Acute encephalopathy (HP:0006846)1.94810174
86Fragile nails (HP:0001808)1.93841398
87Increased CSF lactate (HP:0002490)1.93786024
88Medulloblastoma (HP:0002885)1.93175735
89Aplasia/hypoplasia of the humerus (HP:0006507)1.92579353
90Breast aplasia (HP:0100783)1.91918580
91Microretrognathia (HP:0000308)1.91172355
92Natal tooth (HP:0000695)1.90775178
93Delayed epiphyseal ossification (HP:0002663)1.90528096
94Abnormality of the parietal bone (HP:0002696)1.90323829
95Abnormality of the distal phalanx of the thumb (HP:0009617)1.89751888
96Reduced antithrombin III activity (HP:0001976)1.89028143
97Broad thumb (HP:0011304)1.88676059
98Short thumb (HP:0009778)1.88629228
99Skin tags (HP:0010609)1.87194731
100Proximal placement of thumb (HP:0009623)1.86824430
101Aplasia/Hypoplasia of the sternum (HP:0006714)1.85936846
102Rhabdomyosarcoma (HP:0002859)1.85736986
103Abnormality of the anterior horn cell (HP:0006802)1.85343978
104Degeneration of anterior horn cells (HP:0002398)1.85343978
105Absent thumb (HP:0009777)1.84060871
106Abnormal gallbladder physiology (HP:0012438)1.84041062
107Cholecystitis (HP:0001082)1.84041062
108Patent foramen ovale (HP:0001655)1.83921899
109Flattened epiphyses (HP:0003071)1.83888274
110Bilateral microphthalmos (HP:0007633)1.83877146
111Chromsome breakage (HP:0040012)1.81303261
112Rectal prolapse (HP:0002035)1.81256545
113Short middle phalanx of the 5th finger (HP:0004220)1.79210415
114Neoplasm of the pancreas (HP:0002894)1.78983992
115Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.76910998
116Aplasia/Hypoplasia of the uvula (HP:0010293)1.76751871
117Glossoptosis (HP:0000162)1.76475765
118Deviation of the thumb (HP:0009603)1.76080484
119Cerebral edema (HP:0002181)1.75987602
120Nephroblastoma (Wilms tumor) (HP:0002667)1.75982712
121Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.75655088
122Vertebral hypoplasia (HP:0008417)1.75655088
123Carpal synostosis (HP:0009702)1.75577921
124Short tibia (HP:0005736)1.75306925
125Septo-optic dysplasia (HP:0100842)1.74917616
126Cleft eyelid (HP:0000625)1.74681183
127Ureteral duplication (HP:0000073)1.74514269
128Preaxial hand polydactyly (HP:0001177)1.74476810
129Sparse lateral eyebrow (HP:0005338)1.74294753
130Embryonal renal neoplasm (HP:0011794)1.73749071
131Oligodactyly (HP:0012165)1.73466268
132Birth length less than 3rd percentile (HP:0003561)1.72355243
133Oral leukoplakia (HP:0002745)1.72097867
134Decreased activity of mitochondrial respiratory chain (HP:0008972)1.71493763
135Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.71493763
136Abnormal connection of the cardiac segments (HP:0011545)1.71215262
137Abnormal ventriculo-arterial connection (HP:0011563)1.71215262
138Transposition of the great arteries (HP:0001669)1.71215262
139Esophageal atresia (HP:0002032)1.70973630
140Ectopic kidney (HP:0000086)1.70845393
141Ependymoma (HP:0002888)1.70656933
142Multiple enchondromatosis (HP:0005701)1.70464045
143Hypoplasia of the radius (HP:0002984)1.70029299
144Hypoplastic labia majora (HP:0000059)1.69640166
145Supernumerary bones of the axial skeleton (HP:0009144)1.69319473
146Abnormality of glycolysis (HP:0004366)1.68804475
147Broad hallux (HP:0010055)1.68777060
148Horseshoe kidney (HP:0000085)1.68262620
149Death in infancy (HP:0001522)1.68084599
150Increased serum lactate (HP:0002151)1.67586457
151Hepatic necrosis (HP:0002605)1.67320581
152Short 5th finger (HP:0009237)1.66672452
153Supernumerary ribs (HP:0005815)1.65302511
154Rough bone trabeculation (HP:0100670)1.65115713
155Carpal bone hypoplasia (HP:0001498)1.64818076
156Abnormality of the preputium (HP:0100587)1.63734543
157Pili torti (HP:0003777)1.62867380
158Premature rupture of membranes (HP:0001788)1.62786871
159Tracheoesophageal fistula (HP:0002575)1.62710491
160Partial duplication of thumb phalanx (HP:0009944)1.61572614
161Neonatal short-limb short stature (HP:0008921)1.61024317
162Small intestinal stenosis (HP:0012848)1.60528340
163Duodenal stenosis (HP:0100867)1.60528340

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.73316767
2BUB14.07274899
3TLK13.51926285
4WEE13.02399995
5EPHB22.84619200
6EPHA22.63198239
7LATS22.61568165
8LATS12.47727946
9CDC72.44298859
10SRPK12.42251008
11NME22.33096680
12BCKDK2.27311915
13TTK2.24139001
14MKNK12.23542216
15SMG12.19094943
16MAP3K102.12841721
17STK38L2.07388571
18MAP4K22.02568001
19RPS6KB22.00461033
20DYRK31.93429462
21TAF11.91587807
22CDK121.91463908
23PAK41.91000050
24NME11.80212115
25CDK71.76297800
26RPS6KA41.74987624
27NEK21.72235062
28MKNK21.65753914
29PLK11.61978265
30PLK41.61043703
31BRSK21.59862070
32PASK1.59035284
33TGFBR11.48736915
34ARAF1.48497071
35AURKB1.45290415
36ZAK1.43668805
37PDK21.41885626
38MAP3K81.40822975
39CHEK21.34071303
40TIE11.31503794
41AURKA1.29699777
42KDR1.27105769
43TRIM281.21054798
44EIF2AK11.20269045
45MST41.19235118
46TAOK21.18754793
47VRK11.18641809
48CDK81.18205289
49MST1R1.15438221
50LRRK21.13839231
51CDK41.09841236
52LMTK21.09540992
53TESK21.08133905
54BMX1.07686518
55PIM21.06893485
56PLK31.02807474
57ATR1.00954116
58TESK11.00248499
59DDR21.00073111
60STK100.99611180
61CDK60.98931026
62PKN20.98249468
63NEK90.96578294
64PRKCI0.90890278
65CHEK10.89006536
66STK30.87483830
67ERBB30.84914114
68BRAF0.84904782
69ILK0.84476800
70NEK10.84091038
71MAPKAPK30.82072325
72FGFR10.80185716
73DYRK20.79779297
74MAP2K20.79464888
75BRSK10.79217826
76EEF2K0.77775797
77TRIB30.76770289
78DYRK1B0.76214557
79MAP3K30.75005240
80CDK90.74903219
81STK160.74772500
82ERN10.73590157
83ACVR1B0.72304280
84TSSK60.69738059
85CDK20.69436137
86FER0.68578296
87MAP3K110.67550962
88ERBB20.65875719
89PTK60.64832436
90FLT30.63434398
91ATM0.62296520
92CLK10.61843487
93PAK10.61732046
94CSNK2A10.61613769
95MTOR0.60166494
96CSNK2A20.59240225
97LIMK10.58053263
98MET0.57428772
99NUAK10.56502218
100SIK10.54673428
101YES10.54655124
102PDGFRA0.54632348
103ERBB40.54378199
104PTK20.51017684
105AKT20.50630856
106CDK190.49904212
107STK40.48731361
108PAK20.48306217
109MELK0.45518397
110CSNK1E0.44197062
111CDK10.44121994
112MATK0.43884881
113DAPK10.41746359
114ABL20.36980871
115BRD40.35918170
116EPHA40.34905377
117RPS6KA50.33819780
118PBK0.33100873
119CDK11A0.33023683
120PRKD30.32194891
121MAP2K60.31622877
122EIF2AK20.29750218
123DAPK30.29450709
124EIF2AK30.28854276
125RPS6KA10.28274824
126PIM10.28195784
127STK240.27979623
128BMPR1B0.27888158
129RAF10.26103864
130ICK0.24897321
131STK390.21306783
132CDK180.20971855
133CDK150.20718069
134INSRR0.19779551

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.96309718
2DNA replication_Homo sapiens_hsa030304.02962549
3Mismatch repair_Homo sapiens_hsa034303.54254966
4Spliceosome_Homo sapiens_hsa030403.24113707
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.79402140
6Homologous recombination_Homo sapiens_hsa034402.79237218
7RNA polymerase_Homo sapiens_hsa030202.76230039
8Base excision repair_Homo sapiens_hsa034102.72428080
9RNA transport_Homo sapiens_hsa030132.63356448
10Nucleotide excision repair_Homo sapiens_hsa034202.61215789
11Cell cycle_Homo sapiens_hsa041102.53351323
12Basal cell carcinoma_Homo sapiens_hsa052172.41850757
13One carbon pool by folate_Homo sapiens_hsa006702.35906512
14Proteasome_Homo sapiens_hsa030502.18990847
15Steroid biosynthesis_Homo sapiens_hsa001002.12456837
16Fanconi anemia pathway_Homo sapiens_hsa034602.05334148
17Pyrimidine metabolism_Homo sapiens_hsa002401.90558606
18Hippo signaling pathway_Homo sapiens_hsa043901.90168756
19Fatty acid elongation_Homo sapiens_hsa000621.88772441
20Hedgehog signaling pathway_Homo sapiens_hsa043401.87983323
21Oxidative phosphorylation_Homo sapiens_hsa001901.87227772
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.84883863
23p53 signaling pathway_Homo sapiens_hsa041151.72452721
24RNA degradation_Homo sapiens_hsa030181.65386465
25mRNA surveillance pathway_Homo sapiens_hsa030151.64341557
26Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.61381323
27Basal transcription factors_Homo sapiens_hsa030221.60726198
28Sulfur relay system_Homo sapiens_hsa041221.56114689
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.47332702
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.47243246
31TGF-beta signaling pathway_Homo sapiens_hsa043501.45776309
32Non-homologous end-joining_Homo sapiens_hsa034501.45594120
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.39144495
34Carbon metabolism_Homo sapiens_hsa012001.38261890
35Cyanoamino acid metabolism_Homo sapiens_hsa004601.38119060
36Bladder cancer_Homo sapiens_hsa052191.37695862
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.35162127
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.35033904
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.34767135
40Thyroid cancer_Homo sapiens_hsa052161.33590024
41MicroRNAs in cancer_Homo sapiens_hsa052061.27422837
42Fructose and mannose metabolism_Homo sapiens_hsa000511.21745057
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.14656453
44Pyruvate metabolism_Homo sapiens_hsa006201.14324110
45Adherens junction_Homo sapiens_hsa045201.13749353
46HTLV-I infection_Homo sapiens_hsa051661.10652277
47Wnt signaling pathway_Homo sapiens_hsa043101.08189708
48Small cell lung cancer_Homo sapiens_hsa052221.05622719
49Tight junction_Homo sapiens_hsa045301.01204652
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.01065891
51Notch signaling pathway_Homo sapiens_hsa043300.98497406
52Propanoate metabolism_Homo sapiens_hsa006400.94649658
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.93060199
54Proteoglycans in cancer_Homo sapiens_hsa052050.92649679
55Vitamin digestion and absorption_Homo sapiens_hsa049770.91845997
56Alzheimers disease_Homo sapiens_hsa050100.90056641
57Epstein-Barr virus infection_Homo sapiens_hsa051690.88188596
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87911389
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83835313
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83492413
61Oocyte meiosis_Homo sapiens_hsa041140.82977735
62Viral carcinogenesis_Homo sapiens_hsa052030.80779969
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.80522562
64Melanoma_Homo sapiens_hsa052180.78334733
65Pathways in cancer_Homo sapiens_hsa052000.78190979
66Metabolic pathways_Homo sapiens_hsa011000.75819655
67Glutathione metabolism_Homo sapiens_hsa004800.75533148
68Purine metabolism_Homo sapiens_hsa002300.74861522
69Fatty acid metabolism_Homo sapiens_hsa012120.72962204
70Glycosaminoglycan degradation_Homo sapiens_hsa005310.72213422
71Herpes simplex infection_Homo sapiens_hsa051680.70756998
72Systemic lupus erythematosus_Homo sapiens_hsa053220.68929987
73Melanogenesis_Homo sapiens_hsa049160.67012931
74Folate biosynthesis_Homo sapiens_hsa007900.66977540
75ECM-receptor interaction_Homo sapiens_hsa045120.66773692
76Colorectal cancer_Homo sapiens_hsa052100.66221692
77Arginine and proline metabolism_Homo sapiens_hsa003300.65148591
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61635752
79Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.61284083
80Prostate cancer_Homo sapiens_hsa052150.60568127
81Chronic myeloid leukemia_Homo sapiens_hsa052200.60133006
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60100417
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59950399
84Protein export_Homo sapiens_hsa030600.59929782
85Huntingtons disease_Homo sapiens_hsa050160.59361311
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57934406
87Peroxisome_Homo sapiens_hsa041460.56227115
88Arachidonic acid metabolism_Homo sapiens_hsa005900.53784389
89Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.52762458
90Vitamin B6 metabolism_Homo sapiens_hsa007500.52608595
91Endometrial cancer_Homo sapiens_hsa052130.52313614
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51393411
93Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.50883444
94Focal adhesion_Homo sapiens_hsa045100.48071893
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.47360766
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.45058457
97* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.44149090
98Biosynthesis of amino acids_Homo sapiens_hsa012300.43636512
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41542623
100Sulfur metabolism_Homo sapiens_hsa009200.38607218
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.37155745
102Fatty acid degradation_Homo sapiens_hsa000710.36704905
103Viral myocarditis_Homo sapiens_hsa054160.36437060
104Selenocompound metabolism_Homo sapiens_hsa004500.35562508
105Acute myeloid leukemia_Homo sapiens_hsa052210.31657194
106Vibrio cholerae infection_Homo sapiens_hsa051100.31626575
107Shigellosis_Homo sapiens_hsa051310.31411058
108Apoptosis_Homo sapiens_hsa042100.31318976
109Cysteine and methionine metabolism_Homo sapiens_hsa002700.31116790
110Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30101661
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.29598143
112Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.28522010
113* Rap1 signaling pathway_Homo sapiens_hsa040150.28119381
114Lysine degradation_Homo sapiens_hsa003100.28056081
115Parkinsons disease_Homo sapiens_hsa050120.27759890
116Hepatitis B_Homo sapiens_hsa051610.27132353
117N-Glycan biosynthesis_Homo sapiens_hsa005100.26550558
118HIF-1 signaling pathway_Homo sapiens_hsa040660.25846024
119Pentose phosphate pathway_Homo sapiens_hsa000300.25776390
120Regulation of autophagy_Homo sapiens_hsa041400.24698495
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24610129
122Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.24443205
123Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.22986808
124Pancreatic cancer_Homo sapiens_hsa052120.22793271
125Alcoholism_Homo sapiens_hsa050340.22489896
126Regulation of actin cytoskeleton_Homo sapiens_hsa048100.22113533
127Protein digestion and absorption_Homo sapiens_hsa049740.22047349
128Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.21897238
129Antigen processing and presentation_Homo sapiens_hsa046120.21513198
130Non-small cell lung cancer_Homo sapiens_hsa052230.21008952
131Phenylalanine metabolism_Homo sapiens_hsa003600.20687316
132Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.19589611
133* Axon guidance_Homo sapiens_hsa043600.19501487
134Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.18569732
135Thyroid hormone signaling pathway_Homo sapiens_hsa049190.18382495
136Cardiac muscle contraction_Homo sapiens_hsa042600.17455365
137Legionellosis_Homo sapiens_hsa051340.16831553
138Other glycan degradation_Homo sapiens_hsa005110.16748379
139mTOR signaling pathway_Homo sapiens_hsa041500.16461055
140Galactose metabolism_Homo sapiens_hsa000520.16326538
141Linoleic acid metabolism_Homo sapiens_hsa005910.14508035
142VEGF signaling pathway_Homo sapiens_hsa043700.13121368
143FoxO signaling pathway_Homo sapiens_hsa040680.12136367
144Drug metabolism - other enzymes_Homo sapiens_hsa009830.10503730

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