EFHD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.13094191
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.13094191
3positive regulation by organism of defense response of other organism involved in symbiotic interact6.13094191
4modulation by symbiont of host immune response (GO:0052553)6.13094191
5positive regulation by symbiont of host defense response (GO:0052509)6.13094191
6modulation by symbiont of host defense response (GO:0052031)6.13094191
7regulation of interferon-beta biosynthetic process (GO:0045357)4.93228753
8detection of other organism (GO:0098543)4.79429323
9macrophage activation involved in immune response (GO:0002281)4.74914192
10detection of bacterium (GO:0016045)4.69488916
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.66457036
12neutrophil activation involved in immune response (GO:0002283)4.50764728
13response to peptidoglycan (GO:0032494)4.36475186
14positive regulation of interferon-alpha production (GO:0032727)4.27608277
15microglial cell activation (GO:0001774)4.21016557
16immunoglobulin mediated immune response (GO:0016064)4.17843717
17response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.17019059
18response to host immune response (GO:0052572)4.17019059
19negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.15299496
20negative regulation of cell killing (GO:0031342)4.15299496
21regulation of B cell receptor signaling pathway (GO:0050855)4.11572730
22regulation of interferon-alpha production (GO:0032647)4.07156439
23respiratory burst (GO:0045730)4.00143179
24detection of external biotic stimulus (GO:0098581)3.99266558
25response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.85615680
26response to host (GO:0075136)3.85615680
27response to host defenses (GO:0052200)3.85615680
28regulation of gamma-delta T cell activation (GO:0046643)3.76758383
29regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.76139120
30negative regulation of lymphocyte mediated immunity (GO:0002707)3.72595185
31Arp2/3 complex-mediated actin nucleation (GO:0034314)3.71506936
32positive regulation of antigen processing and presentation (GO:0002579)3.69345477
33antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.69001029
34antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.69001029
35negative regulation of erythrocyte differentiation (GO:0045647)3.66288429
36positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.63086213
37detection of molecule of bacterial origin (GO:0032490)3.59871392
38myeloid cell activation involved in immune response (GO:0002275)3.52344592
39antigen processing and presentation of endogenous antigen (GO:0019883)3.51819583
40negative regulation of leukocyte mediated immunity (GO:0002704)3.50161376
41detection of biotic stimulus (GO:0009595)3.48908086
42cellular extravasation (GO:0045123)3.45244358
43granulocyte activation (GO:0036230)3.44173174
44lipopolysaccharide-mediated signaling pathway (GO:0031663)3.42561786
45macrophage activation (GO:0042116)3.40609849
46antigen processing and presentation via MHC class Ib (GO:0002475)3.38620315
47germinal center formation (GO:0002467)3.34466610
48neutrophil activation (GO:0042119)3.32610852
49leukocyte migration involved in inflammatory response (GO:0002523)3.31397790
50response to interleukin-15 (GO:0070672)3.30040456
51positive regulation of gamma-delta T cell activation (GO:0046645)3.29031809
52regulation of T cell tolerance induction (GO:0002664)3.28460908
53response to muramyl dipeptide (GO:0032495)3.22750833
54interferon-gamma-mediated signaling pathway (GO:0060333)3.22736328
55positive regulation of mast cell activation (GO:0033005)3.22733459
56regulation of gamma-delta T cell differentiation (GO:0045586)3.22022679
57regulation of tolerance induction (GO:0002643)3.15522747
58leukocyte aggregation (GO:0070486)3.13116768
59negative regulation of T cell mediated immunity (GO:0002710)3.12080922
60NIK/NF-kappaB signaling (GO:0038061)3.10234068
61regulation of T-helper 2 cell differentiation (GO:0045628)3.09559576
62defense response to protozoan (GO:0042832)3.06634540
63regulation of antigen processing and presentation (GO:0002577)3.04951878
64B cell mediated immunity (GO:0019724)3.03134376
65negative regulation of phagocytosis (GO:0050765)3.02676295
66lymphocyte chemotaxis (GO:0048247)3.01963322
67cellular response to interleukin-15 (GO:0071350)3.00384944
68actin nucleation (GO:0045010)2.99403796
69positive regulation of cellular amide metabolic process (GO:0034250)2.99222664
70regulation of mononuclear cell migration (GO:0071675)2.96877721
71positive thymic T cell selection (GO:0045059)2.96454083
72B cell receptor signaling pathway (GO:0050853)2.96161118
73myeloid dendritic cell differentiation (GO:0043011)2.94744618
74negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.94069924
75negative regulation of interleukin-12 production (GO:0032695)2.93014590
76negative regulation of cytokine production involved in immune response (GO:0002719)2.92606177
77regulation of cholesterol storage (GO:0010885)2.92438333
78positive regulation of B cell differentiation (GO:0045579)2.91021070
79hydrogen peroxide biosynthetic process (GO:0050665)2.89578039
80positive regulation of interferon-beta production (GO:0032728)2.89551171
81positive regulation of chemokine biosynthetic process (GO:0045080)2.89256096
82regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.89162370
83regulation of natural killer cell mediated immunity (GO:0002715)2.89162370
84regulation of mast cell degranulation (GO:0043304)2.86705062
85positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.85204383
86production of molecular mediator involved in inflammatory response (GO:0002532)2.85127449
87leukocyte degranulation (GO:0043299)2.84507101
88negative regulation of innate immune response (GO:0045824)2.84482624
89type I interferon signaling pathway (GO:0060337)2.84135084
90cellular response to type I interferon (GO:0071357)2.84135084
91response to protozoan (GO:0001562)2.83717455
92neutrophil chemotaxis (GO:0030593)2.83343353
93regulation of T cell mediated cytotoxicity (GO:0001914)2.83263365
94regulation of B cell differentiation (GO:0045577)2.83165230
95pinocytosis (GO:0006907)2.83049609
96response to type I interferon (GO:0034340)2.81982807
97myeloid dendritic cell activation (GO:0001773)2.81340316
98regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.80790905
99regulation of leukocyte degranulation (GO:0043300)2.80567624
100negative regulation of interleukin-6 production (GO:0032715)2.80343764
101positive regulation of mast cell degranulation (GO:0043306)2.80117085
102positive regulation of mast cell activation involved in immune response (GO:0033008)2.80117085
103negative regulation of type 2 immune response (GO:0002829)2.75977103
104phagosome maturation (GO:0090382)2.75935289
105positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.75615001
106positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.75601397
107positive regulation of Cdc42 GTPase activity (GO:0043089)2.74828136
108neutrophil migration (GO:1990266)2.73986053
109positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.72919573
110positive regulation of T cell mediated cytotoxicity (GO:0001916)2.72684842
111myeloid leukocyte activation (GO:0002274)2.71984466
112neutrophil mediated immunity (GO:0002446)2.68632602
113regulation of mast cell activation (GO:0033003)2.66775112
114regulation of myeloid leukocyte mediated immunity (GO:0002886)2.66141168
115I-kappaB phosphorylation (GO:0007252)2.65215594
116regulation of interleukin-8 biosynthetic process (GO:0045414)2.64997209
117positive regulation of lamellipodium assembly (GO:0010592)2.63572271
118positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.63339457
119natural killer cell mediated immunity (GO:0002228)2.62440639
120natural killer cell mediated cytotoxicity (GO:0042267)2.62440639
121regulation of mast cell activation involved in immune response (GO:0033006)2.62270249
122reactive oxygen species biosynthetic process (GO:1903409)2.61608663
123leukocyte cell-cell adhesion (GO:0007159)2.61051613
124positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.61035427
125regulation of interleukin-12 biosynthetic process (GO:0045075)2.60171541
126negative regulation of interleukin-17 production (GO:0032700)2.58016597
127JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.57935167
128low-density lipoprotein particle clearance (GO:0034383)2.57290212
129dendritic cell differentiation (GO:0097028)2.57263967
130positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.56019923
131actin filament polymerization (GO:0030041)2.55558042
132leukocyte mediated cytotoxicity (GO:0001909)2.54841644
133positive regulation of leukocyte degranulation (GO:0043302)2.54337414
134regulation of dendritic cell antigen processing and presentation (GO:0002604)2.54103848
135positive regulation of macrophage cytokine production (GO:0060907)2.53973627
136regulation of regulated secretory pathway (GO:1903305)2.53057506
137T cell migration (GO:0072678)2.52595519
138mature B cell differentiation (GO:0002335)2.50624783
139negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.50019254
140apoptotic cell clearance (GO:0043277)2.49158726
141cellular response to interferon-gamma (GO:0071346)2.48990056
142granulocyte chemotaxis (GO:0071621)2.48367172

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse5.74881564
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.79927572
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.23163586
4* IRF8_27001747_Chip-Seq_BMDM_Mouse4.05264887
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.83827382
6NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.39676519
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.28198669
8Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.10873742
9EGR1_19374776_ChIP-ChIP_THP-1_Human3.05104541
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.02912594
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.02145673
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.93109213
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.89431820
14NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.71622857
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.43956035
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.43113324
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.42139574
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.36948793
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.34024176
20BRD4_27068464_Chip-Seq_AML-cells_Mouse2.28414488
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.15631051
22* SPI1_23127762_ChIP-Seq_K562_Human2.10034100
23VDR_21846776_ChIP-Seq_THP-1_Human2.06757857
24VDR_24763502_ChIP-Seq_THP-1_Human2.06643236
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.04197973
26MAF_26560356_Chip-Seq_TH1_Human1.92067815
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.91968309
28PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.91500370
29* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.87174992
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.87120910
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.83756450
32RUNX_20019798_ChIP-Seq_JUKART_Human1.79969003
33* SPI1_23547873_ChIP-Seq_NB4_Human1.78202159
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.77379161
35TCF7_22412390_ChIP-Seq_EML_Mouse1.76864082
36E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.74431020
37VDR_24787735_ChIP-Seq_THP-1_Human1.66334609
38MYB_26560356_Chip-Seq_TH2_Human1.62560619
39* KDM2B_26808549_Chip-Seq_DND41_Human1.61908448
40PU_27001747_Chip-Seq_BMDM_Mouse1.59911576
41STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.58348825
42SCL_19346495_ChIP-Seq_HPC-7_Human1.58193542
43* LXR_22292898_ChIP-Seq_THP-1_Human1.57152796
44FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.56913815
45CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.53161998
46* ELK3_25401928_ChIP-Seq_HUVEC_Human1.50801999
47NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.50543040
48* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.44293947
49TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42790779
50* UTX_26944678_Chip-Seq_JUKART_Human1.40651141
51CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.40188368
52MYC_22102868_ChIP-Seq_BL_Human1.39420378
53STAT6_21828071_ChIP-Seq_BEAS2B_Human1.36916028
54MYB_26560356_Chip-Seq_TH1_Human1.35502559
55MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.33995490
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30306263
57RARG_19884340_ChIP-ChIP_MEFs_Mouse1.29789257
58* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.29138718
59PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28675487
60TP63_17297297_ChIP-ChIP_HaCaT_Human1.28376554
61BCOR_27268052_Chip-Seq_Bcells_Human1.27009600
62CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24854654
63GATA2_21666600_ChIP-Seq_HMVEC_Human1.23474168
64SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21624171
65PU.1_20513432_ChIP-Seq_Bcells_Mouse1.19989126
66MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.19817959
67* SA1_27219007_Chip-Seq_ERYTHROID_Human1.17693230
68TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16608560
69* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16209959
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15810553
71GATA1_19941827_ChIP-Seq_MEL_Mouse1.14857458
72PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14304894
73MAF_26560356_Chip-Seq_TH2_Human1.12802398
74LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.08676443
75P68_20966046_ChIP-Seq_HELA_Human1.08031050
76STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.07828432
77CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07344312
78RACK7_27058665_Chip-Seq_MCF-7_Human1.06647444
79TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06493317
80* NCOR1_26117541_ChIP-Seq_K562_Human1.06295236
81SMAD_19615063_ChIP-ChIP_OVARY_Human1.04978882
82CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.04805759
83EGR1_19032775_ChIP-ChIP_M12_Human1.04797749
84* GATA3_27048872_Chip-Seq_THYMUS_Human1.04337528
85ELF1_20517297_ChIP-Seq_JURKAT_Human1.03433474
86SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01817406
87GATA1_19941826_ChIP-Seq_K562_Human1.00299802
88TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99452402
89SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99191983
90SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98651893
91GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.98329867
92PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97279203
93* KDM2B_26808549_Chip-Seq_K562_Human0.96341224
94* GATA2_19941826_ChIP-Seq_K562_Human0.96238290
95* KDM2B_26808549_Chip-Seq_JURKAT_Human0.94818757
96CTCF_27219007_Chip-Seq_ERYTHROID_Human0.94200596
97SPI1_20517297_ChIP-Seq_HL60_Human0.94196049
98* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.94047073
99* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.93663827
100CDX2_20551321_ChIP-Seq_CACO-2_Human0.91757103
101VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.91687628
102* SMC4_20622854_ChIP-Seq_HELA_Human0.91366856
103CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.90093250
104SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.88993258
105SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.88739560
106* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.83662430
107* GATA3_26560356_Chip-Seq_TH2_Human0.83615761
108* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.83459389
109* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.83369235
110CDX2_19796622_ChIP-Seq_MESCs_Mouse0.81669850
111BCL6_27268052_Chip-Seq_Bcells_Human0.81259232
112* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80687913
113CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.80561360
114LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.79573819
115ESR2_21235772_ChIP-Seq_MCF-7_Human0.78945197
116* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.77244182
117ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.77147886

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.85401223
2MP0005058_abnormal_lysosome_morphology3.57884665
3MP0001835_abnormal_antigen_presentation3.57823810
4MP0003436_decreased_susceptibility_to3.43821150
5MP0006082_CNS_inflammation3.35273687
6MP0004510_myositis3.19001857
7MP0002419_abnormal_innate_immunity2.91612942
8MP0009785_altered_susceptibility_to2.90168625
9MP0003172_abnormal_lysosome_physiology2.71823266
10MP0005000_abnormal_immune_tolerance2.68145012
11MP0002148_abnormal_hypersensitivity_rea2.63759072
12MP0005025_abnormal_response_to2.56621602
13MP0005387_immune_system_phenotype2.48822218
14MP0001790_abnormal_immune_system2.48822218
15MP0003300_gastrointestinal_ulcer2.47351320
16MP0002452_abnormal_antigen_presenting2.38762213
17MP0009840_abnormal_foam_cell2.38112326
18MP0000685_abnormal_immune_system2.33427314
19MP0005671_abnormal_response_to2.30854062
20MP0001800_abnormal_humoral_immune2.20707942
21MP0005464_abnormal_platelet_physiology2.18640853
22MP0002723_abnormal_immune_serum2.17725196
23MP0003075_altered_response_to2.14675504
24MP0001819_abnormal_immune_cell2.07812046
25MP0003724_increased_susceptibility_to2.06622166
26MP0002420_abnormal_adaptive_immunity2.05184999
27MP0003191_abnormal_cellular_cholesterol2.04474809
28MP0003763_abnormal_thymus_physiology1.99978751
29MP0001533_abnormal_skeleton_physiology1.98607806
30MP0000604_amyloidosis1.96913347
31MP0008260_abnormal_autophagy1.94925862
32MP0005451_abnormal_body_composition1.90772536
33MP0004947_skin_inflammation1.83435004
34MP0003448_altered_tumor_morphology1.80417408
35MP0003183_abnormal_peptide_metabolism1.77079922
36MP0005167_abnormal_blood-brain_barrier1.75401628
37MP0000343_altered_response_to1.73044035
38MP0001845_abnormal_inflammatory_respons1.72314967
39MP0005310_abnormal_salivary_gland1.72266773
40MP0002405_respiratory_system_inflammati1.70386682
41MP0005166_decreased_susceptibility_to1.66506630
42MP0009278_abnormal_bone_marrow1.66264454
43MP0003690_abnormal_glial_cell1.59288672
44MP0010155_abnormal_intestine_physiology1.55832121
45MP0008469_abnormal_protein_level1.51780984
46MP0000569_abnormal_digit_pigmentation1.47908196
47MP0000716_abnormal_immune_system1.45494201
48MP0001853_heart_inflammation1.44208879
49MP0002132_abnormal_respiratory_system1.42420926
50MP0002998_abnormal_bone_remodeling1.38512610
51MP0004858_abnormal_nervous_system1.36581536
52MP0002398_abnormal_bone_marrow1.36166300
53MP0004859_abnormal_synaptic_plasticity1.35676220
54MP0002396_abnormal_hematopoietic_system1.32196817
55MP0009764_decreased_sensitivity_to1.30352645
56MP0005397_hematopoietic_system_phenotyp1.30149691
57MP0001545_abnormal_hematopoietic_system1.30149691
58MP0005076_abnormal_cell_differentiation1.28469584
59MP0000858_altered_metastatic_potential1.28007789
60MP0009333_abnormal_splenocyte_physiolog1.25667230
61MP0001851_eye_inflammation1.22141742
62MP0000689_abnormal_spleen_morphology1.20143029
63MP0000703_abnormal_thymus_morphology1.19138246
64MP0002138_abnormal_hepatobiliary_system1.18963153
65MP0003566_abnormal_cell_adhesion1.16577993
66MP0002166_altered_tumor_susceptibility1.16488255
67MP0002429_abnormal_blood_cell1.16091809
68MP0002006_tumorigenesis1.13461740
69MP0003806_abnormal_nucleotide_metabolis1.12036642
70MP0003866_abnormal_defecation1.10392611
71MP0002722_abnormal_immune_system1.09699610
72MP0001873_stomach_inflammation1.09621188
73MP0010307_abnormal_tumor_latency1.02226219
74MP0003828_pulmonary_edema1.02095344
75MP0002277_abnormal_respiratory_mucosa1.01603984
76MP0005174_abnormal_tail_pigmentation1.01568885
77MP0001663_abnormal_digestive_system1.01367154
78MP0002933_joint_inflammation1.00801434
79MP0003705_abnormal_hypodermis_morpholog0.95948040
80MP0002254_reproductive_system_inflammat0.94954933
81MP0000465_gastrointestinal_hemorrhage0.90705418
82MP0005164_abnormal_response_to0.89903305
83MP0000249_abnormal_blood_vessel0.87923872
84MP0003091_abnormal_cell_migration0.85763951
85MP0003045_fibrosis0.84962037
86MP0004381_abnormal_hair_follicle0.84259863
87MP0003453_abnormal_keratinocyte_physiol0.83520300
88MP0010234_abnormal_vibrissa_follicle0.81542698
89MP0003329_amyloid_beta_deposits0.76109473
90MP0005083_abnormal_biliary_tract0.75848475
91MP0003656_abnormal_erythrocyte_physiolo0.75385481
92MP0004130_abnormal_muscle_cell0.74823529
93MP0001501_abnormal_sleep_pattern0.74724531
94MP0000490_abnormal_crypts_of0.74380914
95MP0005390_skeleton_phenotype0.73445206
96MP0002090_abnormal_vision0.72963310
97MP0008004_abnormal_stomach_pH0.72549949
98MP0009763_increased_sensitivity_to0.72181380
99MP0004883_abnormal_blood_vessel0.69842531
100MP0001849_ear_inflammation0.69726717
101MP0003633_abnormal_nervous_system0.69613872
102MP0002877_abnormal_melanocyte_morpholog0.66585999
103MP0002064_seizures0.66199424
104MP0003879_abnormal_hair_cell0.65006859
105MP0008874_decreased_physiological_sensi0.63892851
106MP0000920_abnormal_myelination0.63420912
107MP0004808_abnormal_hematopoietic_stem0.63189967
108MP0010352_gastrointestinal_tract_polyps0.61413965
109MP0009765_abnormal_xenobiotic_induced0.59868118
110MP0008873_increased_physiological_sensi0.59724243
111MP0003795_abnormal_bone_structure0.59040995
112MP0005319_abnormal_enzyme/_coenzyme0.56340345
113MP0005381_digestive/alimentary_phenotyp0.56305186
114MP0005023_abnormal_wound_healing0.55871226
115MP0004185_abnormal_adipocyte_glucose0.54345538
116MP0002332_abnormal_exercise_endurance0.50221745

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.16001187
2Eczematoid dermatitis (HP:0000976)6.01904766
3Increased cerebral lipofuscin (HP:0011813)5.42012400
4Recurrent bacterial skin infections (HP:0005406)5.35803628
5Recurrent gram-negative bacterial infections (HP:0005420)4.95211986
6Systemic lupus erythematosus (HP:0002725)4.83206408
7Abnormality of macrophages (HP:0004311)4.60919802
8Increased neuronal autofluorescent lipopigment (HP:0002074)4.53314761
9Vacuolated lymphocytes (HP:0001922)4.26658740
10Dysostosis multiplex (HP:0000943)4.01035741
11Abnormality of glycolipid metabolism (HP:0010969)3.95279086
12Abnormality of liposaccharide metabolism (HP:0010968)3.95279086
13Abnormality of glycosphingolipid metabolism (HP:0004343)3.95279086
14Mediastinal lymphadenopathy (HP:0100721)3.87431478
15Myositis (HP:0100614)3.85140567
16Obstructive lung disease (HP:0006536)3.78335573
17Chronic obstructive pulmonary disease (HP:0006510)3.78335573
18Elevated erythrocyte sedimentation rate (HP:0003565)3.71387330
19Axonal loss (HP:0003447)3.50913105
20Stomatitis (HP:0010280)3.50229702
21Disinhibition (HP:0000734)3.49516187
22Glomerulonephritis (HP:0000099)3.47360095
23Orchitis (HP:0100796)3.37207172
24Urinary glycosaminoglycan excretion (HP:0003541)3.34784680
25Mucopolysacchariduria (HP:0008155)3.34784680
26Gingivitis (HP:0000230)3.30445983
27Recurrent skin infections (HP:0001581)3.26636738
28Autoimmune thrombocytopenia (HP:0001973)3.22296079
29Abnormal delayed hypersensitivity skin test (HP:0002963)3.20483737
30Recurrent fungal infections (HP:0002841)3.19220260
31Encephalitis (HP:0002383)3.16331718
32Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.14986913
33Loss of speech (HP:0002371)3.08032371
34Abnormality of mucopolysaccharide metabolism (HP:0011020)3.07556152
35Abnormality of polysaccharide metabolism (HP:0011012)3.07556152
36Abnormality of glycosaminoglycan metabolism (HP:0004371)3.07556152
37Myocardial infarction (HP:0001658)2.93586667
38Retrobulbar optic neuritis (HP:0100654)2.92837229
39Optic neuritis (HP:0100653)2.92837229
40Interstitial pulmonary disease (HP:0006530)2.86549353
41Prolonged bleeding time (HP:0003010)2.72760903
42Chronic otitis media (HP:0000389)2.71865040
43Keratoconjunctivitis (HP:0001096)2.70138680
44Pustule (HP:0200039)2.69946745
45Urticaria (HP:0001025)2.69886409
46Cellulitis (HP:0100658)2.68092215
47Hematochezia (HP:0002573)2.66976917
48Mutism (HP:0002300)2.63702834
49Basal ganglia calcification (HP:0002135)2.60078659
50Recurrent viral infections (HP:0004429)2.55414223
51Episodic fever (HP:0001954)2.55008189
52Vasculitis (HP:0002633)2.52007006
53Spontaneous hematomas (HP:0007420)2.48517918
54Diminished motivation (HP:0000745)2.45448247
55T lymphocytopenia (HP:0005403)2.43176140
56Nasal polyposis (HP:0100582)2.42330623
57Purpura (HP:0000979)2.41908588
58Epistaxis (HP:0000421)2.41860908
59Malnutrition (HP:0004395)2.41777948
60Increased serum ferritin (HP:0003281)2.39887324
61Hypochromic anemia (HP:0001931)2.39376231
62Nephritis (HP:0000123)2.39111594
63Periodontitis (HP:0000704)2.38900772
64Abnormality of the nasal mucosa (HP:0000433)2.38115570
65Meningitis (HP:0001287)2.37114993
66Apathy (HP:0000741)2.35876450
67Arterial thrombosis (HP:0004420)2.35126841
68Neuronal loss in central nervous system (HP:0002529)2.33187340
69Abnormality of T cell number (HP:0011839)2.29987879
70Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.28283081
71Inflammation of the large intestine (HP:0002037)2.27019036
72Anorexia (HP:0002039)2.26420453
73Agnosia (HP:0010524)2.25149406
74Amyloidosis (HP:0011034)2.24698702
75Pulmonary embolism (HP:0002204)2.24307890
76Abnormality of complement system (HP:0005339)2.23589372
77J-shaped sella turcica (HP:0002680)2.23241549
78Hypochromic microcytic anemia (HP:0004840)2.21585821
79Granulocytopenia (HP:0001913)2.21268617
80Colitis (HP:0002583)2.20725022
81Complement deficiency (HP:0004431)2.19237423
82Recurrent cutaneous fungal infections (HP:0011370)2.19229941
83Chronic mucocutaneous candidiasis (HP:0002728)2.19229941
84Peritonitis (HP:0002586)2.18453293
85Tetraparesis (HP:0002273)2.17469564
86Premature loss of primary teeth (HP:0006323)2.16692758
87Panhypogammaglobulinemia (HP:0003139)2.16118952
88Sepsis (HP:0100806)2.16030749
89Gastrointestinal inflammation (HP:0004386)2.15396731
90Pulmonary infiltrates (HP:0002113)2.14594217
91Inappropriate behavior (HP:0000719)2.13409695
92Abnormality of T cells (HP:0002843)2.10688540
93Lymphopenia (HP:0001888)2.09156067
94Supranuclear gaze palsy (HP:0000605)2.06964754
95Abnormality of iron homeostasis (HP:0011031)2.06950181
96Gastrointestinal stroma tumor (HP:0100723)2.06680682
97Increased IgE level (HP:0003212)2.05055204
98Hepatosplenomegaly (HP:0001433)2.04092358
99Slow saccadic eye movements (HP:0000514)2.03471842
100Thoracic kyphosis (HP:0002942)2.03318035
101Skin ulcer (HP:0200042)2.02117699
102Abnormality of cells of the lymphoid lineage (HP:0012140)2.00847241
103Segmental peripheral demyelination/remyelination (HP:0003481)2.00689066
104Glomerulopathy (HP:0100820)1.99265524
105Thick nail (HP:0001805)1.98187421
106Petechiae (HP:0000967)1.97957057
107Abnormality of the lumbar spine (HP:0100712)1.97938947
108Abnormality of the pleura (HP:0002103)1.95205676
109Polygenic inheritance (HP:0010982)1.94548320
110Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.93875943
111Leukocytosis (HP:0001974)1.92876617
112Papilledema (HP:0001085)1.91887853
113Gangrene (HP:0100758)1.91581528
114Agammaglobulinemia (HP:0004432)1.91491906
115Impaired platelet aggregation (HP:0003540)1.90801706
116Abnormal platelet function (HP:0011869)1.90801706
117Hypergammaglobulinemia (HP:0010702)1.90756481
118Osteomyelitis (HP:0002754)1.90656518
119Frequent falls (HP:0002359)1.90423702
120Chest pain (HP:0100749)1.88842833
121Global brain atrophy (HP:0002283)1.88561992
122Acne (HP:0001061)1.88321055
123Restrictive lung disease (HP:0002091)1.87897260
124Increased IgM level (HP:0003496)1.87175572
125Gingival bleeding (HP:0000225)1.86799626
126Hemoptysis (HP:0002105)1.86052000
127Abnormality of the peritoneum (HP:0002585)1.84972385
128Abnormality of T cell physiology (HP:0011840)1.84186393
129Bone pain (HP:0002653)1.83964640
130Asymmetric septal hypertrophy (HP:0001670)1.81164898
131Increased CSF protein (HP:0002922)1.81094457
132Upper motor neuron abnormality (HP:0002127)1.81060311
133Abnormality of binocular vision (HP:0011514)1.78443307
134Diplopia (HP:0000651)1.78443307
135Keratoconjunctivitis sicca (HP:0001097)1.76876370
136Gastrointestinal infarctions (HP:0005244)1.76209245
137Abnormality of the vasculature of the conjunctiva (HP:0008054)1.76202829
138Esophageal varix (HP:0002040)1.73724632

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.17030388
2BLK3.29707491
3TBK13.20740841
4PRPF4B3.03286475
5TRIB32.87199264
6TYK22.46853247
7MAP4K12.39516116
8MAP3K142.22523620
9ERN12.10318635
10FES2.08836388
11IRAK42.03453256
12KIT1.98392624
13MAP3K91.94002032
14PKN21.91715161
15MAP3K131.89299521
16IRAK31.83840918
17TGFBR21.83077960
18IKBKE1.78265491
19JAK11.68730136
20FGR1.68157444
21DAPK21.66500216
22CSF1R1.63586906
23RIPK11.59755356
24CSK1.57909616
25ZAP701.54176423
26TAOK21.49082851
27EPHB11.48650883
28MAP3K111.43829140
29KSR21.43490520
30CAMKK11.43231691
31JAK31.43034868
32PIM21.39940778
33SMG11.39327326
34MAP3K121.37547989
35SIK31.35715337
36HCK1.32390820
37IKBKB1.28809316
38TAOK11.26624038
39GRK61.23478462
40BMX1.23157709
41SYK1.21783691
42MATK1.19308565
43JAK21.18523097
44SCYL21.14127472
45TXK1.10884776
46SIK11.07976005
47SIK21.07869750
48PTK61.07806687
49ARAF1.06029142
50MAP3K11.01119155
51ALK1.00791672
52STK101.00284981
53PRKD21.00274416
54MARK20.99825431
55NEK90.98867044
56LCK0.98205473
57PAK40.97100385
58MAP3K100.94953605
59MAP2K30.94422404
60CDC42BPA0.94178200
61LRRK20.91723789
62DMPK0.89111673
63IRAK20.88975149
64TESK10.88366640
65GRK70.88265885
66BTK0.86176775
67DAPK10.83770303
68TAOK30.82978243
69DAPK30.81191887
70CAMKK20.80593205
71PBK0.79974417
72PDK10.79959310
73LYN0.79002830
74PDPK10.76212285
75YES10.75697338
76NME20.71450771
77MAP3K50.71100870
78MAP3K30.69439382
79IRAK10.68779300
80PRKG20.68758710
81EGFR0.68648037
82CAMK1D0.68578568
83CLK10.66926954
84MOS0.66114970
85RPS6KA40.64751766
86TESK20.64243813
87MAPK120.64124467
88MAP3K60.62037655
89MST40.60502195
90ABL20.60327777
91ITK0.59711529
92FGFR40.59642506
93FGFR30.59592944
94HIPK20.57920627
95PTK2B0.56803247
96CAMK1G0.56275691
97PAK60.55793714
98CHUK0.53074496
99PRKCD0.52993163
100MAP3K70.51608662
101FYN0.51521306
102TEC0.51298168
103ICK0.50980622
104MAP3K80.50956909
105RET0.50519798
106RPS6KL10.50099591
107RPS6KC10.50099591
108PRKCH0.49688312
109MAPK70.49262817
110MAP2K60.47714483
111MAP3K20.47382329
112RAF10.47223366
113PIM10.46651991
114ABL10.46529770
115CDK190.41877495
116MAPKAPK20.41282784
117STK110.41212827
118CDK60.41090626
119MARK30.39692501
120STK380.38446964
121DYRK1B0.37525766
122TTN0.37283475
123PRKCQ0.37251264
124TNK20.36617177
125RPS6KA60.36598397
126CDK40.35695221
127MAPK40.35375591
128RPS6KA20.33752462
129SGK30.33656362
130BMPR20.33082249

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.87405675
2Staphylococcus aureus infection_Homo sapiens_hsa051502.85277215
3Osteoclast differentiation_Homo sapiens_hsa043802.50528517
4Lysosome_Homo sapiens_hsa041422.29757474
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.24101232
6Autoimmune thyroid disease_Homo sapiens_hsa053202.21922816
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.14018344
8Tuberculosis_Homo sapiens_hsa051522.05909535
9Pertussis_Homo sapiens_hsa051332.04203412
10Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.95635445
11B cell receptor signaling pathway_Homo sapiens_hsa046621.84227762
12Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.81790544
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.77412536
14Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.70590188
15Salmonella infection_Homo sapiens_hsa051321.69702593
16Legionellosis_Homo sapiens_hsa051341.67541217
17Other glycan degradation_Homo sapiens_hsa005111.66798505
18Graft-versus-host disease_Homo sapiens_hsa053321.62364089
19Antigen processing and presentation_Homo sapiens_hsa046121.57199028
20Shigellosis_Homo sapiens_hsa051311.52820583
21Phagosome_Homo sapiens_hsa041451.52151851
22Toxoplasmosis_Homo sapiens_hsa051451.49243668
23Chemokine signaling pathway_Homo sapiens_hsa040621.45107738
24Rheumatoid arthritis_Homo sapiens_hsa053231.43759677
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.42949593
26Malaria_Homo sapiens_hsa051441.42746874
27Measles_Homo sapiens_hsa051621.40278915
28TNF signaling pathway_Homo sapiens_hsa046681.40127481
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.39106460
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.38919636
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.30706405
32Influenza A_Homo sapiens_hsa051641.30375281
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.29705102
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.27426534
35Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.17483022
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.16519826
37Apoptosis_Homo sapiens_hsa042101.12312815
38Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.12082717
39Synaptic vesicle cycle_Homo sapiens_hsa047211.08791685
40Allograft rejection_Homo sapiens_hsa053301.07021378
41Neurotrophin signaling pathway_Homo sapiens_hsa047221.03050852
42Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.01934116
43VEGF signaling pathway_Homo sapiens_hsa043701.01819465
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.99490417
45Hepatitis B_Homo sapiens_hsa051610.99342467
46Intestinal immune network for IgA production_Homo sapiens_hsa046720.99340588
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.97520387
48African trypanosomiasis_Homo sapiens_hsa051430.96700637
49T cell receptor signaling pathway_Homo sapiens_hsa046600.96241948
50Collecting duct acid secretion_Homo sapiens_hsa049660.94649376
51Acute myeloid leukemia_Homo sapiens_hsa052210.93450904
52Hematopoietic cell lineage_Homo sapiens_hsa046400.91670149
53Endocytosis_Homo sapiens_hsa041440.91057655
54Platelet activation_Homo sapiens_hsa046110.90757124
55Jak-STAT signaling pathway_Homo sapiens_hsa046300.89173613
56Amoebiasis_Homo sapiens_hsa051460.87980798
57Asthma_Homo sapiens_hsa053100.86900235
58Chronic myeloid leukemia_Homo sapiens_hsa052200.84120041
59Hepatitis C_Homo sapiens_hsa051600.83702718
60Pancreatic cancer_Homo sapiens_hsa052120.83665336
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.83159581
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82663323
63Sphingolipid signaling pathway_Homo sapiens_hsa040710.81565732
64Viral myocarditis_Homo sapiens_hsa054160.78573409
65Nitrogen metabolism_Homo sapiens_hsa009100.78478274
66Prion diseases_Homo sapiens_hsa050200.78257843
67Type I diabetes mellitus_Homo sapiens_hsa049400.77071387
68Notch signaling pathway_Homo sapiens_hsa043300.76271542
69Prolactin signaling pathway_Homo sapiens_hsa049170.73474818
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73329069
71Herpes simplex infection_Homo sapiens_hsa051680.71237816
72Glioma_Homo sapiens_hsa052140.70682939
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70342185
74HIF-1 signaling pathway_Homo sapiens_hsa040660.69206158
75Mineral absorption_Homo sapiens_hsa049780.68875537
76Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.68357541
77Regulation of actin cytoskeleton_Homo sapiens_hsa048100.67341832
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66974058
79Epstein-Barr virus infection_Homo sapiens_hsa051690.66332925
80Type II diabetes mellitus_Homo sapiens_hsa049300.65604678
81Dorso-ventral axis formation_Homo sapiens_hsa043200.65515565
82Primary immunodeficiency_Homo sapiens_hsa053400.63615181
83Bladder cancer_Homo sapiens_hsa052190.62137035
84HTLV-I infection_Homo sapiens_hsa051660.58796567
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.57573230
86Viral carcinogenesis_Homo sapiens_hsa052030.57522972
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56865608
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54201200
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53055672
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.52632873
91Gastric acid secretion_Homo sapiens_hsa049710.52292456
92Non-small cell lung cancer_Homo sapiens_hsa052230.52284524
93Renal cell carcinoma_Homo sapiens_hsa052110.51911645
94Choline metabolism in cancer_Homo sapiens_hsa052310.50985925
95Endometrial cancer_Homo sapiens_hsa052130.50680897
96Olfactory transduction_Homo sapiens_hsa047400.49979683
97Estrogen signaling pathway_Homo sapiens_hsa049150.49075200
98Complement and coagulation cascades_Homo sapiens_hsa046100.49070466
99Caffeine metabolism_Homo sapiens_hsa002320.47521750
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47047668
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47008667
102Proteoglycans in cancer_Homo sapiens_hsa052050.46782504
103GnRH signaling pathway_Homo sapiens_hsa049120.46649257
104Vibrio cholerae infection_Homo sapiens_hsa051100.45648797
105Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.45222140
106FoxO signaling pathway_Homo sapiens_hsa040680.45025127
107Galactose metabolism_Homo sapiens_hsa000520.43997037
108Insulin resistance_Homo sapiens_hsa049310.43485825
109Salivary secretion_Homo sapiens_hsa049700.43072867
110Renin secretion_Homo sapiens_hsa049240.41720773
111Rap1 signaling pathway_Homo sapiens_hsa040150.41232866
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.40692381
113mTOR signaling pathway_Homo sapiens_hsa041500.40439812
114ErbB signaling pathway_Homo sapiens_hsa040120.40401555
115Inositol phosphate metabolism_Homo sapiens_hsa005620.40075700
116MAPK signaling pathway_Homo sapiens_hsa040100.39609333
117Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39421400
118Colorectal cancer_Homo sapiens_hsa052100.38751790
119Long-term potentiation_Homo sapiens_hsa047200.38353686
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.38252012
121Fructose and mannose metabolism_Homo sapiens_hsa000510.36597951

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