EFHD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the EF-hand super family of calcium binding proteins, which are involved in a variety of cellular processes including mitosis, synaptic transmission, and cytoskeletal rearrangement. The protein encoded by this gene is composed of an N-terminal disordered region, proline-rich elements, two EF-hands, and a C-terminal coiled-coil domain. This protein has been shown to associate with the mitochondrial inner membrane, and in HeLa cells, acts as a novel mitochondrial calcium ion sensor for mitochondrial flash activation. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)9.87952661
2central nervous system myelination (GO:0022010)9.87952661
3cilium or flagellum-dependent cell motility (GO:0001539)6.73415167
4fusion of sperm to egg plasma membrane (GO:0007342)6.65109270
5acrosome reaction (GO:0007340)6.08793190
6sperm motility (GO:0030317)5.98660006
7piRNA metabolic process (GO:0034587)5.77322165
8axonemal dynein complex assembly (GO:0070286)5.63964278
9synaptic vesicle docking involved in exocytosis (GO:0016081)5.61015985
10axon ensheathment (GO:0008366)5.53510760
11ensheathment of neurons (GO:0007272)5.53510760
12myelin maintenance (GO:0043217)5.51329334
13sodium ion export (GO:0071436)5.44875574
14glutamate secretion (GO:0014047)5.43808002
15multicellular organism reproduction (GO:0032504)5.41509858
16myelination (GO:0042552)5.40989003
17fatty acid elongation (GO:0030497)5.30365936
18synaptic vesicle maturation (GO:0016188)5.19531083
19acrosome assembly (GO:0001675)5.17341995
20cellular potassium ion homeostasis (GO:0030007)5.07489076
21synaptic vesicle exocytosis (GO:0016079)5.03741703
22negative regulation of inclusion body assembly (GO:0090084)5.03344646
23plasma membrane fusion (GO:0045026)5.02459973
24epithelial cilium movement (GO:0003351)5.02197912
25sperm capacitation (GO:0048240)4.85984660
26sperm-egg recognition (GO:0035036)4.77568766
27protein polyglutamylation (GO:0018095)4.66840260
28cell wall macromolecule metabolic process (GO:0044036)4.61433606
29cell wall macromolecule catabolic process (GO:0016998)4.61433606
30epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.60303266
31male meiosis (GO:0007140)4.55096462
32reproduction (GO:0000003)4.49282835
33regulation of cilium movement (GO:0003352)4.45528667
34spermatid development (GO:0007286)4.38786065
35synaptonemal complex organization (GO:0070193)4.37935299
36cilium movement (GO:0003341)4.36453885
37neuronal ion channel clustering (GO:0045161)4.29658921
38C21-steroid hormone biosynthetic process (GO:0006700)4.29133979
39regulation of synaptic vesicle exocytosis (GO:2000300)4.25852071
40membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.20681207
41cell-cell recognition (GO:0009988)4.19808098
42motile cilium assembly (GO:0044458)4.16583859
43synaptonemal complex assembly (GO:0007130)4.15124042
44long-chain fatty acid biosynthetic process (GO:0042759)4.12459793
45regulation of short-term neuronal synaptic plasticity (GO:0048172)4.11948144
46positive regulation of synapse maturation (GO:0090129)4.04643399
47positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.03543379
48binding of sperm to zona pellucida (GO:0007339)4.02217302
49neurotransmitter secretion (GO:0007269)3.97755530
50locomotory exploration behavior (GO:0035641)3.90827097
51establishment of mitochondrion localization (GO:0051654)3.86279584
52cerebellar granule cell differentiation (GO:0021707)3.84954032
53cytoskeletal anchoring at plasma membrane (GO:0007016)3.83661291
54cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.82809466
55potassium ion import (GO:0010107)3.78617871
56positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.78267198
57single fertilization (GO:0007338)3.74824245
58response to methylmercury (GO:0051597)3.72252893
59DNA methylation involved in gamete generation (GO:0043046)3.71992310
60creatine metabolic process (GO:0006600)3.68464753
61regulation of synaptic vesicle transport (GO:1902803)3.68350011
62asymmetric protein localization (GO:0008105)3.67962859
63regulation of neuronal synaptic plasticity (GO:0048168)3.66700800
64astrocyte development (GO:0014002)3.62466595
65regulation of microtubule-based movement (GO:0060632)3.59048608
66microtubule severing (GO:0051013)3.56389591
67cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.53318515
68regulation of inclusion body assembly (GO:0090083)3.50767752
69fertilization (GO:0009566)3.48574358
70response to lead ion (GO:0010288)3.46396294
71vocalization behavior (GO:0071625)3.44577929
72negative regulation of neurotransmitter secretion (GO:0046929)3.42028541
73L-amino acid import (GO:0043092)3.36069155
74negative regulation of neurotransmitter transport (GO:0051589)3.34293281
75estrogen biosynthetic process (GO:0006703)3.33166288
76glucocorticoid biosynthetic process (GO:0006704)3.32845044
77regulation of ARF protein signal transduction (GO:0032012)3.30813038
78regulation of collateral sprouting (GO:0048670)3.30569086
79negative regulation of synaptic transmission, GABAergic (GO:0032229)3.30286778
80ventricular system development (GO:0021591)3.26944698
81synaptic vesicle endocytosis (GO:0048488)3.25188867
82regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.24965450
83cell communication by electrical coupling (GO:0010644)3.24237143
84neurotransmitter transport (GO:0006836)3.23819872
85organic cation transport (GO:0015695)3.21973015
86androgen biosynthetic process (GO:0006702)3.19386269
87oligodendrocyte differentiation (GO:0048709)3.19221583
88cellular sodium ion homeostasis (GO:0006883)3.17743570
89postsynaptic membrane organization (GO:0001941)3.14856234
90regulation of long-term neuronal synaptic plasticity (GO:0048169)3.14290826
91regulation of clathrin-mediated endocytosis (GO:2000369)3.14024493
92neuronal action potential propagation (GO:0019227)3.14013266
93membrane tubulation (GO:0097320)3.11552908
94regulation of synapse maturation (GO:0090128)3.11228848
95myelination in peripheral nervous system (GO:0022011)3.09867228
96peripheral nervous system axon ensheathment (GO:0032292)3.09867228
97long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.08852820
98spermatogenesis (GO:0007283)3.08698414
99male gamete generation (GO:0048232)3.07130731
100neuromuscular process controlling balance (GO:0050885)3.05595929
101response to mercury ion (GO:0046689)3.03540089
102regulation of synaptic plasticity (GO:0048167)3.03262129
103microtubule polymerization or depolymerization (GO:0031109)3.02879218
104positive regulation of oligodendrocyte differentiation (GO:0048714)3.02807234
105neurotransmitter uptake (GO:0001504)3.02236741
106exploration behavior (GO:0035640)3.02007319
107auditory behavior (GO:0031223)3.01784316
108regulation of neurotransmitter levels (GO:0001505)3.00317708
109negative regulation of protein localization to cell surface (GO:2000009)3.00286098
110male meiosis I (GO:0007141)2.98417800
111long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.96589460
112apical protein localization (GO:0045176)2.96350552
113eye photoreceptor cell differentiation (GO:0001754)2.96241068
114photoreceptor cell differentiation (GO:0046530)2.96241068
115substantia nigra development (GO:0021762)2.95291872
116ionotropic glutamate receptor signaling pathway (GO:0035235)2.95044685
117regulation of lipoprotein metabolic process (GO:0050746)2.91436362
118cell communication involved in cardiac conduction (GO:0086065)2.91315748
119gamete generation (GO:0007276)2.87202370
120calcium ion-dependent exocytosis (GO:0017156)2.86604417
121negative regulation of macroautophagy (GO:0016242)2.85692290
122regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.84517244
123fatty-acyl-CoA biosynthetic process (GO:0046949)2.83744153
124activation of protein kinase A activity (GO:0034199)2.83437247
125cellular response to cadmium ion (GO:0071276)2.80481095
126Leydig cell differentiation (GO:0033327)2.80221747
127protein localization to endosome (GO:0036010)2.78875750
128regulation of glutamate receptor signaling pathway (GO:1900449)2.77823222
129regulation of somitogenesis (GO:0014807)2.74531236
130regulation of female receptivity (GO:0045924)2.73710411
131germ cell development (GO:0007281)2.73117082
132regulation of voltage-gated calcium channel activity (GO:1901385)2.72184556
133regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.71925809
134positive regulation of dendritic spine development (GO:0060999)2.71693178
135neurotransmitter-gated ion channel clustering (GO:0072578)2.70731783
136cellular process involved in reproduction in multicellular organism (GO:0022412)2.67978556
137enteric nervous system development (GO:0048484)2.67313399
138neuron cell-cell adhesion (GO:0007158)2.66741767
139positive regulation of membrane potential (GO:0045838)2.66030184
140sex differentiation (GO:0007548)2.64772293
141cerebellar Purkinje cell layer development (GO:0021680)2.64718068
142fatty-acyl-CoA metabolic process (GO:0035337)2.63004882
143regulation of cholesterol biosynthetic process (GO:0045540)2.62979415
144cholesterol biosynthetic process (GO:0006695)2.62545622
145glucocorticoid metabolic process (GO:0008211)2.61707242
146acidic amino acid transport (GO:0015800)2.61225558
147polyol transport (GO:0015791)2.60671741
148response to auditory stimulus (GO:0010996)2.59668070
149peptidyl-tyrosine autophosphorylation (GO:0038083)2.59560037
150regulation of neurotransmitter secretion (GO:0046928)2.59463509
151dendritic spine morphogenesis (GO:0060997)2.57939549
152regulation of synapse structural plasticity (GO:0051823)2.57813164
153cell recognition (GO:0008037)2.57330087
154dendritic spine organization (GO:0097061)2.57274110
155regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.57241989
156negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.56753874
157long-term memory (GO:0007616)2.56747977
158long-term synaptic potentiation (GO:0060291)2.56115445
159potassium ion homeostasis (GO:0055075)2.52636487
160response to parathyroid hormone (GO:0071107)2.52460132
161peripheral nervous system development (GO:0007422)2.52217985
162regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.51935346
163negative regulation of dendrite morphogenesis (GO:0050774)2.50395310
164sterol biosynthetic process (GO:0016126)2.47356077
165positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.46772000
166positive regulation of dendrite development (GO:1900006)2.46567908
167presynaptic membrane organization (GO:0097090)2.46267164
168negative regulation of microtubule polymerization (GO:0031115)2.46091746
169meiotic nuclear division (GO:0007126)2.44986290
170cell migration in hindbrain (GO:0021535)2.44563743
171very long-chain fatty acid metabolic process (GO:0000038)2.44203413
172import into cell (GO:0098657)2.44086827
173regulation of neurotransmitter transport (GO:0051588)2.43515912
174layer formation in cerebral cortex (GO:0021819)2.42998533
175gamma-aminobutyric acid transport (GO:0015812)2.41945335
176regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.41823871
177amino acid import (GO:0043090)2.41789320
178regulation of excitatory postsynaptic membrane potential (GO:0060079)2.40554876
179regulation of p38MAPK cascade (GO:1900744)2.40293233
180neuromuscular process controlling posture (GO:0050884)2.40182891
181dicarboxylic acid transport (GO:0006835)2.39679471
182dopamine receptor signaling pathway (GO:0007212)2.39668549
183synaptic transmission, glutamatergic (GO:0035249)2.38167188

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.76427855
2EZH2_22144423_ChIP-Seq_EOC_Human3.41799032
3ESR1_20079471_ChIP-ChIP_T-47D_Human3.31434344
4THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.04265544
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.87887271
6* TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.62412760
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.55683461
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.46336483
9* ESR1_21235772_ChIP-Seq_MCF-7_Human2.45828061
10ZFP281_18757296_ChIP-ChIP_E14_Mouse2.15747936
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.06358788
12KDM2B_26808549_Chip-Seq_K562_Human2.03927045
13LXR_22292898_ChIP-Seq_THP-1_Human1.89413871
14DNAJC2_21179169_ChIP-ChIP_NT2_Human1.77401003
15VDR_22108803_ChIP-Seq_LS180_Human1.75641173
16GATA1_26923725_Chip-Seq_HPCs_Mouse1.73932305
17SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.72203828
18RACK7_27058665_Chip-Seq_MCF-7_Human1.71442304
19WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.71296728
20EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.68943951
21* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.67306009
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.63334758
23* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.59185305
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57198291
25ESR1_15608294_ChIP-ChIP_MCF-7_Human1.56789762
26* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.54584514
27* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.53814744
28* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.51737824
29* EED_16625203_ChIP-ChIP_MESCs_Mouse1.50990466
30KDM2B_26808549_Chip-Seq_SUP-B15_Human1.49573480
31SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.47561162
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.44590152
33TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44169061
34ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.43562658
35CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.42444169
36ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.41924291
37SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.39400216
38SMC4_20622854_ChIP-Seq_HELA_Human1.39017934
39RARG_19884340_ChIP-ChIP_MEFs_Mouse1.37071458
40STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.36753162
41* EZH2_27294783_Chip-Seq_ESCs_Mouse1.36375689
42* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33777450
43RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.33357360
44GBX2_23144817_ChIP-Seq_PC3_Human1.33297103
45RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30612321
46PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.30562939
47* RNF2_27304074_Chip-Seq_ESCs_Mouse1.28772062
48CREB1_26743006_Chip-Seq_LNCaP_Human1.28498646
49* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.28433661
50ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.28283626
51TRIM28_21343339_ChIP-Seq_HEK293_Human1.25758330
52CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.24835845
53* CBX2_27304074_Chip-Seq_ESCs_Mouse1.24701595
54REST_21632747_ChIP-Seq_MESCs_Mouse1.24654479
55DROSHA_22980978_ChIP-Seq_HELA_Human1.24532373
56* RUNX1_27514584_Chip-Seq_MCF-7_Human1.23514215
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23411984
58CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.23086073
59ERG_21242973_ChIP-ChIP_JURKAT_Human1.22897338
60MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18945298
61KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.18427463
62ZNF263_19887448_ChIP-Seq_K562_Human1.18330504
63TAL1_26923725_Chip-Seq_HPCs_Mouse1.17664726
64NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.17127960
65SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.15123319
66* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.15070816
67* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.15070816
68PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.14971989
69ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.14239717
70KDM2B_26808549_Chip-Seq_DND41_Human1.14051854
71* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.14041367
72OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.13550492
73* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.13151912
74SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13025647
75SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.11222783
76WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10599671
77EP300_21415370_ChIP-Seq_HL-1_Mouse1.10525727
78P68_20966046_ChIP-Seq_HELA_Human1.10381133
79OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08723331
80UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.08390079
81JARID2_20064375_ChIP-Seq_MESCs_Mouse1.08337016
82SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08221154
83TBL1_22424771_ChIP-Seq_293T_Human1.07837105
84* TP53_20018659_ChIP-ChIP_R1E_Mouse1.06800677
85EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.04681664
86CTCF_27219007_Chip-Seq_Bcells_Human1.04372537
87GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04255918
88SMAD4_21741376_ChIP-Seq_EPCs_Human1.02616026
89* OCT4_19829295_ChIP-Seq_ESCs_Human1.02254548
90RNF2_27304074_Chip-Seq_NSC_Mouse1.02209531
91ER_23166858_ChIP-Seq_MCF-7_Human1.01900593
92TET1_21490601_ChIP-Seq_MESCs_Mouse1.01743486
93ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.01656213
94ZFP57_27257070_Chip-Seq_ESCs_Mouse1.01402315
95RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.01275588
96NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00490060
97* EZH2_27304074_Chip-Seq_ESCs_Mouse0.99634382
98TET1_21451524_ChIP-Seq_MESCs_Mouse0.99543952
99RARB_27405468_Chip-Seq_BRAIN_Mouse0.98730491
100ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98402739
101FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.98086240
102CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97240043
103ARNT_22903824_ChIP-Seq_MCF-7_Human0.97007056
104ELK4_26923725_Chip-Seq_MESODERM_Mouse0.96729064
105* RING1B_27294783_Chip-Seq_ESCs_Mouse0.96302549
106TBX20_22328084_ChIP-Seq_HEART_Mouse0.95860220
107TBX20_22080862_ChIP-Seq_HEART_Mouse0.95860220
108STAT6_21828071_ChIP-Seq_BEAS2B_Human0.95717329
109SA1_27219007_Chip-Seq_ERYTHROID_Human0.94565441
110SMAD3_21741376_ChIP-Seq_EPCs_Human0.94286112
111AHR_22903824_ChIP-Seq_MCF-7_Human0.93455596
112GF1_26923725_Chip-Seq_HPCs_Mouse0.93429340
113ZNF274_21170338_ChIP-Seq_K562_Hela0.93403637
114EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92957006
115PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.92768485
116TP53_23651856_ChIP-Seq_MEFs_Mouse0.92668802
117KLF4_19829295_ChIP-Seq_ESCs_Human0.92466324
118* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.92214380
119DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.91909053
120SRY_22984422_ChIP-ChIP_TESTIS_Rat0.91183648
121CTBP1_25329375_ChIP-Seq_LNCAP_Human0.91042043
122* CLOCK_20551151_ChIP-Seq_293T_Human0.90456349
123* PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.90119817
124NFIB_24661679_ChIP-Seq_LUNG_Mouse0.89763243
125* KDM2B_26808549_Chip-Seq_REH_Human0.89385432
126SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.88314825
127* RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.88127551
128TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87740535
129CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87665353
130NFYB_21822215_ChIP-Seq_K562_Human0.87584382
131POU5F1_16518401_ChIP-PET_MESCs_Mouse0.87217272
132RAD21_21589869_ChIP-Seq_MESCs_Mouse0.86994502
133TAF15_26573619_Chip-Seq_HEK293_Human0.86739121
134FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86729054
135ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.86665716
136POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.86597644
137TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86597644
138TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.85552449
139NANOG_18555785_Chip-Seq_ESCs_Mouse0.85091141
140PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.84752695
141* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.83916698
142RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.83693123
143REST_18959480_ChIP-ChIP_MESCs_Mouse0.83447213
144CTCF_20526341_ChIP-Seq_ESCs_Human0.83071629
145* P300_18555785_Chip-Seq_ESCs_Mouse0.82671406
146* RING1B_27294783_Chip-Seq_NPCs_Mouse0.82611058
147* JARID2_20075857_ChIP-Seq_MESCs_Mouse0.81658547
148* KLF4_18555785_Chip-Seq_ESCs_Mouse0.81656670
149* CMYC_18555785_Chip-Seq_ESCs_Mouse0.80939618
150LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80607279
151TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.80295291
152* TCF4_23295773_ChIP-Seq_U87_Human0.79841930
153NFYA_21822215_ChIP-Seq_K562_Human0.79769957
154PHF8_20622853_ChIP-Seq_HELA_Human0.79646941
155MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.79265307
156STAT3_23295773_ChIP-Seq_U87_Human0.79137848
157EOMES_21245162_ChIP-Seq_HESCs_Human0.78687677
158* ESR2_21235772_ChIP-Seq_MCF-7_Human0.77621800
159* MYC_27129775_Chip-Seq_CORNEA_Mouse0.76458555
160LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.76321051
161SMAD3_21741376_ChIP-Seq_ESCs_Human0.75465814
162MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.75194242

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.68133676
2MP0000920_abnormal_myelination4.22421039
3MP0009780_abnormal_chondrocyte_physiolo3.46348975
4MP0004043_abnormal_pH_regulation3.02427338
5MP0003698_abnormal_male_reproductive2.95313452
6MP0004885_abnormal_endolymph2.84913137
7MP0005171_absent_coat_pigmentation2.74247048
8MP0003950_abnormal_plasma_membrane2.72312798
9MP0003329_amyloid_beta_deposits2.57123144
10MP0001929_abnormal_gametogenesis2.55859396
11MP0005623_abnormal_meninges_morphology2.54473174
12MP0001485_abnormal_pinna_reflex2.43382135
13MP0005377_hearing/vestibular/ear_phenot2.38004957
14MP0003878_abnormal_ear_physiology2.38004957
15MP0003690_abnormal_glial_cell2.35859316
16MP0002653_abnormal_ependyma_morphology2.31827416
17MP0003634_abnormal_glial_cell2.10447781
18MP0004742_abnormal_vestibular_system2.10349712
19MP0008877_abnormal_DNA_methylation2.04479455
20MP0003136_yellow_coat_color2.02753523
21MP0001968_abnormal_touch/_nociception1.91336189
22MP0001502_abnormal_circadian_rhythm1.88120551
23MP0005646_abnormal_pituitary_gland1.86544941
24MP0002272_abnormal_nervous_system1.85950439
25MP0004270_analgesia1.81347984
26MP0009046_muscle_twitch1.80670312
27MP0001486_abnormal_startle_reflex1.77239795
28MP0003880_abnormal_central_pattern1.71938192
29MP0002210_abnormal_sex_determination1.70938591
30MP0003195_calcinosis1.69632655
31MP0002161_abnormal_fertility/fecundity1.62024300
32MP0001145_abnormal_male_reproductive1.59674742
33MP0000639_abnormal_adrenal_gland1.57643792
34MP0001963_abnormal_hearing_physiology1.55378519
35MP0001177_atelectasis1.51642909
36MP0004142_abnormal_muscle_tone1.49914087
37MP0001765_abnormal_ion_homeostasis1.48751397
38MP0001881_abnormal_mammary_gland1.47081965
39MP0004134_abnormal_chest_morphology1.46679631
40MP0000778_abnormal_nervous_system1.44583431
41MP0002229_neurodegeneration1.42088601
42MP0002249_abnormal_larynx_morphology1.38780934
43MP0000462_abnormal_digestive_system1.37890623
44MP0000653_abnormal_sex_gland1.35237389
45MP0002064_seizures1.34433404
46MP0003632_abnormal_nervous_system1.34318406
47MP0002736_abnormal_nociception_after1.33941490
48MP0001661_extended_life_span1.32505527
49MP0003879_abnormal_hair_cell1.31798309
50MP0003631_nervous_system_phenotype1.30639517
51MP0003705_abnormal_hypodermis_morpholog1.27317230
52MP0003633_abnormal_nervous_system1.26821571
53MP0008569_lethality_at_weaning1.25030091
54MP0001529_abnormal_vocalization1.22401459
55MP0002735_abnormal_chemical_nociception1.22320801
56MP0001905_abnormal_dopamine_level1.22242709
57MP0005670_abnormal_white_adipose1.20896460
58MP0001501_abnormal_sleep_pattern1.20253372
59MP0010678_abnormal_skin_adnexa1.19493642
60MP0003123_paternal_imprinting1.18946435
61MP0002557_abnormal_social/conspecific_i1.18686977
62MP0000747_muscle_weakness1.18629040
63MP0004811_abnormal_neuron_physiology1.09625252
64MP0000955_abnormal_spinal_cord1.06052379
65MP0001440_abnormal_grooming_behavior1.04482524
66MP0000026_abnormal_inner_ear1.04278106
67MP0000604_amyloidosis1.04140383
68MP0005423_abnormal_somatic_nervous1.03591819
69MP0000751_myopathy1.01552517
70MP0003787_abnormal_imprinting0.97248514
71MP0005647_abnormal_sex_gland0.97099392
72MP0002882_abnormal_neuron_morphology0.97052372
73MP0004145_abnormal_muscle_electrophysio0.96664703
74MP0000627_abnormal_mammary_gland0.95517731
75MP0000383_abnormal_hair_follicle0.95500171
76MP0003635_abnormal_synaptic_transmissio0.95305835
77MP0002733_abnormal_thermal_nociception0.95065940
78MP0004233_abnormal_muscle_weight0.95035396
79MP0008260_abnormal_autophagy0.94737069
80MP0002098_abnormal_vibrissa_morphology0.94429094
81MP0002089_abnormal_postnatal_growth/wei0.94401821
82MP0002066_abnormal_motor_capabilities/c0.93179398
83MP0000566_synostosis0.92825431
84MP0001348_abnormal_lacrimal_gland0.90600118
85MP0000579_abnormal_nail_morphology0.90054831
86MP0010030_abnormal_orbit_morphology0.88760378
87MP0002184_abnormal_innervation0.88634209
88MP0005386_behavior/neurological_phenoty0.87023550
89MP0004924_abnormal_behavior0.87023550
90MP0003938_abnormal_ear_development0.86602228
91MP0008874_decreased_physiological_sensi0.86107488
92MP0003183_abnormal_peptide_metabolism0.85824685
93MP0005551_abnormal_eye_electrophysiolog0.85612157
94MP0002572_abnormal_emotion/affect_behav0.85208683
95MP0002752_abnormal_somatic_nervous0.85008654
96MP0005058_abnormal_lysosome_morphology0.84682644
97MP0002067_abnormal_sensory_capabilities0.83949093
98MP0005503_abnormal_tendon_morphology0.83780877
99MP0006276_abnormal_autonomic_nervous0.81183827
100MP0000749_muscle_degeneration0.81039315
101MP0005409_darkened_coat_color0.80405901
102MP0008438_abnormal_cutaneous_collagen0.80290657
103MP0005195_abnormal_posterior_eye0.79793631
104MP0002254_reproductive_system_inflammat0.79608004
105MP0008995_early_reproductive_senescence0.79315294
106MP0000762_abnormal_tongue_morphology0.78666365
107MP0004859_abnormal_synaptic_plasticity0.78578735
108MP0002734_abnormal_mechanical_nocicepti0.78536962
109MP0001984_abnormal_olfaction0.78206372
110MP0004381_abnormal_hair_follicle0.77998773
111MP0004130_abnormal_muscle_cell0.77366681
112MP0004272_abnormal_basement_membrane0.77183943
113MP0009745_abnormal_behavioral_response0.76582893
114MP0002796_impaired_skin_barrier0.76206710
115MP0000647_abnormal_sebaceous_gland0.76149569
116MP0003075_altered_response_to0.75741990
117MP0002282_abnormal_trachea_morphology0.74964044
118MP0010234_abnormal_vibrissa_follicle0.74796118
119MP0000534_abnormal_ureter_morphology0.74257292
120MP0002822_catalepsy0.74251097
121MP0002152_abnormal_brain_morphology0.74163133
122MP0002295_abnormal_pulmonary_circulatio0.74064101
123MP0001958_emphysema0.73726605
124MP0002896_abnormal_bone_mineralization0.72848936
125MP0004133_heterotaxia0.72718094
126MP0001340_abnormal_eyelid_morphology0.72654953
127MP0005167_abnormal_blood-brain_barrier0.72240405
128MP0004036_abnormal_muscle_relaxation0.70976689
129MP0001970_abnormal_pain_threshold0.70294445
130MP0004264_abnormal_extraembryonic_tissu0.69559184
131MP0001293_anophthalmia0.69201067
132MP0002063_abnormal_learning/memory/cond0.68644012
133MP0005332_abnormal_amino_acid0.67776997
134MP0004858_abnormal_nervous_system0.67724941
135MP0001756_abnormal_urination0.66083125
136MP0002909_abnormal_adrenal_gland0.66046475
137MP0005636_abnormal_mineral_homeostasis0.64505677
138MP0004147_increased_porphyrin_level0.64388568
139MP0009672_abnormal_birth_weight0.63969369
140MP0001299_abnormal_eye_distance/0.63512919
141MP0000681_abnormal_thyroid_gland0.63320801
142MP0003279_aneurysm0.62785786
143MP0003936_abnormal_reproductive_system0.62390165
144MP0002108_abnormal_muscle_morphology0.62294252
145MP0006072_abnormal_retinal_apoptosis0.61606542
146MP0002160_abnormal_reproductive_system0.60857106
147MP0005253_abnormal_eye_physiology0.60553404
148MP0002009_preneoplasia0.59876500
149MP0001346_abnormal_lacrimal_gland0.59251405

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.30599494
2Dynein arm defect of respiratory motile cilia (HP:0012255)6.49096776
3Absent/shortened dynein arms (HP:0200106)6.49096776
4Increased circulating renin level (HP:0000848)5.12100604
5Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.69253356
6Degeneration of the lateral corticospinal tracts (HP:0002314)4.69253356
7Neurofibrillary tangles (HP:0002185)4.67323616
8Abnormal respiratory motile cilium physiology (HP:0012261)4.66743368
9Abnormal respiratory motile cilium morphology (HP:0005938)4.47952577
10Abnormal respiratory epithelium morphology (HP:0012253)4.47952577
11Renal salt wasting (HP:0000127)4.22912543
12Segmental peripheral demyelination/remyelination (HP:0003481)4.10812761
13Peripheral hypomyelination (HP:0007182)4.10073447
14Hypokalemic alkalosis (HP:0001949)4.08072027
15Metabolic alkalosis (HP:0200114)4.05049526
16Obstructive sleep apnea (HP:0002870)3.89238734
17Focal motor seizures (HP:0011153)3.83791425
18Rhinitis (HP:0012384)3.75218110
19Abnormal ciliary motility (HP:0012262)3.71749255
20Hypomagnesemia (HP:0002917)3.64245438
21Onion bulb formation (HP:0003383)3.59593413
22Infertility (HP:0000789)3.56520459
23Male infertility (HP:0003251)3.41665141
24Cerebral inclusion bodies (HP:0100314)3.39264966
25Abnormality of the corticospinal tract (HP:0002492)3.36499567
26Abnormal auditory evoked potentials (HP:0006958)3.35615509
27Abnormal drinking behavior (HP:0030082)3.34524093
28Polydipsia (HP:0001959)3.34524093
29Termporal pattern (HP:0011008)3.32691474
30Insidious onset (HP:0003587)3.32691474
31Chronic bronchitis (HP:0004469)3.25681622
32Polyuria (HP:0000103)3.24424391
33Focal seizures (HP:0007359)3.12467587
34Abnormal urine output (HP:0012590)3.06964828
35Hyperaldosteronism (HP:0000859)3.01611168
36Epileptic encephalopathy (HP:0200134)2.93709900
37Abnormality of renal excretion (HP:0011036)2.87650142
38Ankle clonus (HP:0011448)2.86714420
39Akinesia (HP:0002304)2.83437518
40Abnormality of binocular vision (HP:0011514)2.83149863
41Diplopia (HP:0000651)2.83149863
42Abnormality of renin-angiotensin system (HP:0000847)2.79804238
43Spastic tetraparesis (HP:0001285)2.78764314
44Abnormality of magnesium homeostasis (HP:0004921)2.78328545
45Alacrima (HP:0000522)2.77805402
46Clumsiness (HP:0002312)2.68464407
47Torticollis (HP:0000473)2.66372266
48Cerebral hypomyelination (HP:0006808)2.65530064
49Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.57388182
50Turricephaly (HP:0000262)2.56094878
51Abnormality of chloride homeostasis (HP:0011422)2.49991001
52Muscle fiber splitting (HP:0003555)2.49851905
53Bundle branch block (HP:0011710)2.48729643
54Bell-shaped thorax (HP:0001591)2.48607246
55Concave nail (HP:0001598)2.48132793
56Spastic gait (HP:0002064)2.45169286
57Febrile seizures (HP:0002373)2.38146836
58Diaphragmatic weakness (HP:0009113)2.37730159
59Intention tremor (HP:0002080)2.37617100
60Nephronophthisis (HP:0000090)2.33953666
61Supranuclear gaze palsy (HP:0000605)2.33315224
62Decreased motor nerve conduction velocity (HP:0003431)2.31572697
63Abnormal eating behavior (HP:0100738)2.31028080
64Coronal craniosynostosis (HP:0004440)2.28739114
65Visual hallucinations (HP:0002367)2.28631477
66Sleep apnea (HP:0010535)2.26741953
67Myokymia (HP:0002411)2.22817117
68Distal lower limb muscle weakness (HP:0009053)2.21735282
69Bronchomalacia (HP:0002780)2.21430213
70Retinal dysplasia (HP:0007973)2.19215478
71Abnormality of the renal medulla (HP:0100957)2.18777007
72Peripheral demyelination (HP:0011096)2.18585673
73Atonic seizures (HP:0010819)2.18197355
74Postural instability (HP:0002172)2.17649208
75Aplasia involving bones of the extremities (HP:0009825)2.17355981
76Aplasia involving bones of the upper limbs (HP:0009823)2.17355981
77Aplasia of the phalanges of the hand (HP:0009802)2.17355981
78Scanning speech (HP:0002168)2.16206633
79Hyperactive renin-angiotensin system (HP:0000841)2.15284220
80Sensory axonal neuropathy (HP:0003390)2.12793917
81Decreased lacrimation (HP:0000633)2.11830609
82Hyperparathyroidism (HP:0000843)2.09548146
83Shallow orbits (HP:0000586)2.09515350
84Morphological abnormality of the inner ear (HP:0011390)2.09204736
85Abnormality of the periventricular white matter (HP:0002518)2.08316173
86Papilledema (HP:0001085)2.08093270
87Stridor (HP:0010307)2.06237959
88Rigidity (HP:0002063)2.05906878
89Truncal ataxia (HP:0002078)2.04850526
90Foot dorsiflexor weakness (HP:0009027)2.03882732
91Ulnar claw (HP:0001178)2.03624882
92Adrenal overactivity (HP:0002717)2.03107079
93Dysmetria (HP:0001310)2.01670274
94Hypoplasia of the uterus (HP:0000013)2.00989074
95Focal dystonia (HP:0004373)1.99902650
96Abnormality of cochlea (HP:0000375)1.99546390
97Anteriorly placed anus (HP:0001545)1.99281996
98Generalized tonic-clonic seizures (HP:0002069)1.98182777
99Lymphangioma (HP:0100764)1.97485946
100Urinary bladder sphincter dysfunction (HP:0002839)1.97382688
101Gowers sign (HP:0003391)1.97245061
102Clonus (HP:0002169)1.96530876
103Insomnia (HP:0100785)1.95766788
104Abnormal atrioventricular conduction (HP:0005150)1.95563148
105Hammertoe (HP:0001765)1.95552544
106Heart block (HP:0012722)1.95210997
107Craniofacial dystonia (HP:0012179)1.94543693
108Annular pancreas (HP:0001734)1.91046960
109Nasal polyposis (HP:0100582)1.90824185
110Depression (HP:0000716)1.90745536
111Hypoplasia of the iris (HP:0007676)1.90646518
112Action tremor (HP:0002345)1.90073000
113Neuronal loss in central nervous system (HP:0002529)1.89951516
114Partial duplication of thumb phalanx (HP:0009944)1.89677220
115Abnormality of potassium homeostasis (HP:0011042)1.88251775
116Infantile muscular hypotonia (HP:0008947)1.85366350
117Rapidly progressive (HP:0003678)1.85008078
118Anxiety (HP:0000739)1.84610462
119Choreoathetosis (HP:0001266)1.83438791
120Lower limb muscle weakness (HP:0007340)1.83300834
121Cerebral aneurysm (HP:0004944)1.82734358
122Broad metatarsal (HP:0001783)1.81653186
123Abnormality of the foot musculature (HP:0001436)1.81604929
124Gonadotropin excess (HP:0000837)1.80722695
125Sparse lateral eyebrow (HP:0005338)1.79484688
126Axonal loss (HP:0003447)1.78871691
127Limb dystonia (HP:0002451)1.78645858
128Hyperacusis (HP:0010780)1.78386575
129Dysdiadochokinesis (HP:0002075)1.77964109
130Mixed hearing impairment (HP:0000410)1.77342484
131Sudden death (HP:0001699)1.76566438
132Bronchiectasis (HP:0002110)1.76078247
133Distal upper limb amyotrophy (HP:0007149)1.75339490
134Upper limb amyotrophy (HP:0009129)1.75339490
135Tetraplegia (HP:0002445)1.75330061
136Lower limb amyotrophy (HP:0007210)1.74713985
137Leukodystrophy (HP:0002415)1.74519365
138Distal sensory impairment (HP:0002936)1.74403562
139Abnormality of molar (HP:0011077)1.74054493
140Abnormality of molar morphology (HP:0011070)1.74054493
141Humeroradial synostosis (HP:0003041)1.73590053
142Synostosis involving the elbow (HP:0003938)1.73590053
143Parakeratosis (HP:0001036)1.73478366
144Alkalosis (HP:0001948)1.72806336
145Premature skin wrinkling (HP:0100678)1.71816703
146Overriding aorta (HP:0002623)1.71631476
147Progressive cerebellar ataxia (HP:0002073)1.71626720
148Gonadal dysgenesis (HP:0000133)1.71513045
149Difficulty running (HP:0009046)1.71157107
150Hypokalemia (HP:0002900)1.71114090
151Urinary urgency (HP:0000012)1.71094229
152CNS hypomyelination (HP:0003429)1.70569060
153Hyporeflexia of lower limbs (HP:0002600)1.70219137
154Megalencephaly (HP:0001355)1.70146012
155Abnormality of permanent molar morphology (HP:0011071)1.66873506
156Abnormality of the dental root (HP:0006486)1.66873506
157Taurodontia (HP:0000679)1.66873506
158Hypercortisolism (HP:0001578)1.66397185
159Difficulty walking (HP:0002355)1.66350960
160Thickened helices (HP:0000391)1.65915416

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.09436509
2WNK44.39089525
3OXSR14.33051058
4ICK3.57457932
5PDK43.33728132
6PDK33.33728132
7NTRK33.13403439
8PRKD33.10091517
9RIPK13.08774913
10DDR22.97636925
11SIK12.92526050
12TRIB32.84904458
13PDK22.64415080
14EPHB12.48113191
15WNK12.37663695
16MAPKAPK52.20301502
17WNK32.17492817
18MAPK152.11946051
19PNCK2.10173497
20TYRO31.96911458
21TESK11.94451171
22PKN11.80698923
23DAPK21.76921958
24CAMKK11.75779147
25MAP3K91.72101683
26MINK11.70198137
27LATS21.65443500
28PINK11.63251588
29UHMK11.61128334
30TESK21.56880999
31DMPK1.53706205
32EPHA21.49752747
33FGFR21.48275628
34MET1.40190795
35PTK2B1.37001012
36SGK2231.29188323
37SGK4941.29188323
38FGR1.25163304
39LIMK11.20220808
40SGK31.17946498
41ARAF1.16948062
42NTRK11.15759228
43BCR1.15505725
44SGK21.13947010
45CAMK2B1.13511162
46CAMK11.12329670
47MAPKAPK31.08443856
48TNK21.04253090
49PKN21.03674682
50CDK190.98734943
51PBK0.97576722
52PAK60.96349168
53DYRK1B0.95590666
54NEK60.94330819
55GRK50.93114067
56ROCK20.90460345
57PHKG20.88489908
58PHKG10.88489908
59SMG10.87267996
60CAMK2D0.87001879
61CSNK1A1L0.84713454
62CAMK2G0.82723267
63MAPK120.82272087
64PRKCG0.81255860
65PTK20.80931032
66BMX0.80004611
67DAPK10.77690138
68EEF2K0.76742445
69ERBB20.74763326
70RPS6KA20.73818862
71ILK0.71606938
72CSNK1G30.71590954
73MARK20.70602311
74PRKD20.70590028
75PDPK10.69899761
76CLK10.69661155
77GSK3A0.68985179
78TRPM70.68057162
79PRKD10.67724344
80CAMK1G0.65462141
81DYRK1A0.64638636
82CSNK1G10.63283424
83NTRK20.63258562
84ALK0.62309739
85RET0.61468811
86PDK10.60618403
87STK380.60040752
88CDK140.59689972
89IRAK20.58216211
90CAMK2A0.57395059
91ROCK10.56566319
92CDK120.56168410
93MAP3K130.55100914
94SCYL20.54668930
95DYRK20.53735738
96CDK150.53373923
97CASK0.53246618
98CDK50.52966088
99MAPK40.52942524
100CAMK40.52637104
101RPS6KA30.51690065
102CSNK1G20.50939249
103BRSK10.49975559
104PLK20.49075363
105FER0.48159265
106STK30.47039288
107CDK180.46385487
108FGFR40.45611662
109CDK11A0.45589760
110MAP3K10.43870792
111MAP2K10.43502842
112PAK10.42057064
113KSR20.41592533
114PIK3CA0.39957966
115PAK30.39312676
116MAPK130.37613349
117MUSK0.37404530
118PAK20.36726635
119MAP2K20.35052629
120AKT30.34210660
121PDGFRB0.33912872
122MAP3K60.33199972
123MARK10.31957033
124PRKACB0.31699638
125LMTK20.31382669
126EPHA40.31322642
127MST40.31041242
128STK110.29818521
129PRKCH0.29264046
130PRKCQ0.29014518
131CSK0.28870708
132CSNK1A10.26948583
133MAPK100.25782101
134SGK10.25119816
135PRKCZ0.24250738
136PRKCE0.23043605
137CSNK1D0.21898178
138YES10.21841205
139DAPK30.21366092
140MTOR0.20743768
141PRPF4B0.19762934
142CDC42BPA0.19693586
143PDGFRA0.18196868
144FYN0.17534786
145CSNK1E0.17458056
146PRKG10.16558355
147PRKACA0.16452229

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid elongation_Homo sapiens_hsa000623.51541488
2Nitrogen metabolism_Homo sapiens_hsa009103.39345078
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.34508914
4Vitamin B6 metabolism_Homo sapiens_hsa007503.31804510
5Fatty acid biosynthesis_Homo sapiens_hsa000613.20669014
6Synaptic vesicle cycle_Homo sapiens_hsa047213.04630065
7Steroid biosynthesis_Homo sapiens_hsa001002.98391291
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.61887441
9Ether lipid metabolism_Homo sapiens_hsa005652.49282040
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.33212376
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.30360605
12Nicotine addiction_Homo sapiens_hsa050332.19781286
13Propanoate metabolism_Homo sapiens_hsa006402.18939600
14Dorso-ventral axis formation_Homo sapiens_hsa043202.18846698
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.11438197
16Linoleic acid metabolism_Homo sapiens_hsa005912.06657292
17Insulin secretion_Homo sapiens_hsa049112.01475668
18Long-term potentiation_Homo sapiens_hsa047201.95246159
19Fatty acid metabolism_Homo sapiens_hsa012121.91050869
20Pyruvate metabolism_Homo sapiens_hsa006201.75131666
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.73118267
22Sulfur metabolism_Homo sapiens_hsa009201.67506876
23Cyanoamino acid metabolism_Homo sapiens_hsa004601.64077030
24Caffeine metabolism_Homo sapiens_hsa002321.60112837
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.56628685
26Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.54283643
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.53922080
28beta-Alanine metabolism_Homo sapiens_hsa004101.45022152
29Mineral absorption_Homo sapiens_hsa049781.43104331
30Dopaminergic synapse_Homo sapiens_hsa047281.42799606
31Arginine and proline metabolism_Homo sapiens_hsa003301.38452942
32Histidine metabolism_Homo sapiens_hsa003401.28814362
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.27200324
34Sphingolipid metabolism_Homo sapiens_hsa006001.25507101
35Butanoate metabolism_Homo sapiens_hsa006501.24746212
36Hedgehog signaling pathway_Homo sapiens_hsa043401.19824009
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.19131864
38Ovarian steroidogenesis_Homo sapiens_hsa049131.17614080
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.17209796
40Glycerophospholipid metabolism_Homo sapiens_hsa005641.16812800
41Cholinergic synapse_Homo sapiens_hsa047251.15824513
42Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.14820364
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.11252571
44Oxytocin signaling pathway_Homo sapiens_hsa049211.10648192
45Axon guidance_Homo sapiens_hsa043601.10019220
46Tight junction_Homo sapiens_hsa045301.09104179
47Vibrio cholerae infection_Homo sapiens_hsa051101.05639413
48Melanogenesis_Homo sapiens_hsa049161.04753796
49Glioma_Homo sapiens_hsa052141.03956556
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.02566710
51Vitamin digestion and absorption_Homo sapiens_hsa049770.99085285
52cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98145656
53Arginine biosynthesis_Homo sapiens_hsa002200.98075727
54Prion diseases_Homo sapiens_hsa050200.97805343
55Calcium signaling pathway_Homo sapiens_hsa040200.96685046
56Gastric acid secretion_Homo sapiens_hsa049710.96244790
57GnRH signaling pathway_Homo sapiens_hsa049120.95944502
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.95436108
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.95195628
60Thyroid hormone signaling pathway_Homo sapiens_hsa049190.93521741
61Glutathione metabolism_Homo sapiens_hsa004800.93100881
62Glycerolipid metabolism_Homo sapiens_hsa005610.93002343
63Phenylalanine metabolism_Homo sapiens_hsa003600.92856217
64AMPK signaling pathway_Homo sapiens_hsa041520.92505262
65Endocytosis_Homo sapiens_hsa041440.89147067
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.88948415
67Protein digestion and absorption_Homo sapiens_hsa049740.88783094
68Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.88339814
69Cardiac muscle contraction_Homo sapiens_hsa042600.85788612
70Collecting duct acid secretion_Homo sapiens_hsa049660.84046971
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83457824
72Arachidonic acid metabolism_Homo sapiens_hsa005900.80787979
73Aldosterone synthesis and secretion_Homo sapiens_hsa049250.80757820
74Dilated cardiomyopathy_Homo sapiens_hsa054140.79271153
75Glutamatergic synapse_Homo sapiens_hsa047240.78929583
76PPAR signaling pathway_Homo sapiens_hsa033200.78875709
77Renin secretion_Homo sapiens_hsa049240.78759371
78Bile secretion_Homo sapiens_hsa049760.78691421
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78057654
80GABAergic synapse_Homo sapiens_hsa047270.76193231
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75388814
82Glucagon signaling pathway_Homo sapiens_hsa049220.73686769
832-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.72909522
84Circadian rhythm_Homo sapiens_hsa047100.72119898
85Taste transduction_Homo sapiens_hsa047420.71252674
86Insulin signaling pathway_Homo sapiens_hsa049100.69115690
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67817427
88Salivary secretion_Homo sapiens_hsa049700.67492595
89Endometrial cancer_Homo sapiens_hsa052130.67301817
90Cocaine addiction_Homo sapiens_hsa050300.66969815
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.66011248
92Rap1 signaling pathway_Homo sapiens_hsa040150.64868314
93Renal cell carcinoma_Homo sapiens_hsa052110.64737245
94Notch signaling pathway_Homo sapiens_hsa043300.64272390
95VEGF signaling pathway_Homo sapiens_hsa043700.63948246
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.63572802
97Amphetamine addiction_Homo sapiens_hsa050310.63423491
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62630090
99ABC transporters_Homo sapiens_hsa020100.62086281
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61827081
101ECM-receptor interaction_Homo sapiens_hsa045120.61414154
102Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.61357967
103Hippo signaling pathway_Homo sapiens_hsa043900.60760347
104Vascular smooth muscle contraction_Homo sapiens_hsa042700.60356627
105Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60212203
106Oxidative phosphorylation_Homo sapiens_hsa001900.57139559
107Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56485438
108Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55195745
109Fatty acid degradation_Homo sapiens_hsa000710.54647949
110Long-term depression_Homo sapiens_hsa047300.53584154
111mTOR signaling pathway_Homo sapiens_hsa041500.52975215
112Pancreatic secretion_Homo sapiens_hsa049720.52808242
113MAPK signaling pathway_Homo sapiens_hsa040100.52260523
114Morphine addiction_Homo sapiens_hsa050320.51335568
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.50448637
116Huntingtons disease_Homo sapiens_hsa050160.49377786
117Peroxisome_Homo sapiens_hsa041460.49128496
118Lysosome_Homo sapiens_hsa041420.47714481
119Olfactory transduction_Homo sapiens_hsa047400.47692187
120Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47302242
121Inositol phosphate metabolism_Homo sapiens_hsa005620.45918078
122Basal cell carcinoma_Homo sapiens_hsa052170.45777506
123Prolactin signaling pathway_Homo sapiens_hsa049170.43958291
124Focal adhesion_Homo sapiens_hsa045100.43506357
125Choline metabolism in cancer_Homo sapiens_hsa052310.42520737
126Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42445866
127cAMP signaling pathway_Homo sapiens_hsa040240.42251757
128Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42246641
129Biosynthesis of amino acids_Homo sapiens_hsa012300.41593173
130Ras signaling pathway_Homo sapiens_hsa040140.41210280
131Wnt signaling pathway_Homo sapiens_hsa043100.40628871
132Oocyte meiosis_Homo sapiens_hsa041140.39058433
133Circadian entrainment_Homo sapiens_hsa047130.39048394
134Metabolic pathways_Homo sapiens_hsa011000.38850336
135Alzheimers disease_Homo sapiens_hsa050100.38256295
136Gap junction_Homo sapiens_hsa045400.38165430
137Folate biosynthesis_Homo sapiens_hsa007900.37978925
138Thyroid hormone synthesis_Homo sapiens_hsa049180.37663169
139ErbB signaling pathway_Homo sapiens_hsa040120.37380860
140Serotonergic synapse_Homo sapiens_hsa047260.37057548
141Basal transcription factors_Homo sapiens_hsa030220.36632519
142Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.36280741
143Estrogen signaling pathway_Homo sapiens_hsa049150.36278709
144Parkinsons disease_Homo sapiens_hsa050120.35530695
145Fat digestion and absorption_Homo sapiens_hsa049750.35071488
146Cysteine and methionine metabolism_Homo sapiens_hsa002700.34481844
147Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32615477
148Phosphatidylinositol signaling system_Homo sapiens_hsa040700.31066113

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