EFHC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an EF-hand-containing calcium binding protein. The encoded protein likely plays a role in calcium homeostasis. Mutations in this gene have been associated with susceptibility to juvenile myoclonic epilepsy and juvenile absence epilepsy. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1binding of sperm to zona pellucida (GO:0007339)9.98104151
2reproduction (GO:0000003)9.95916843
3cilium movement (GO:0003341)9.88984809
4acrosome reaction (GO:0007340)9.72166755
5motile cilium assembly (GO:0044458)9.65168470
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.85173687
7spermatid development (GO:0007286)8.51295961
8male meiosis (GO:0007140)8.41508086
9piRNA metabolic process (GO:0034587)8.14524238
10regulation of cilium movement (GO:0003352)8.06753671
11single fertilization (GO:0007338)7.76596662
12sperm capacitation (GO:0048240)7.54252551
13synaptonemal complex organization (GO:0070193)7.34922591
14synaptonemal complex assembly (GO:0007130)7.09274839
15ventricular system development (GO:0021591)6.57624940
16fertilization (GO:0009566)6.28607201
17spermatogenesis (GO:0007283)5.44995181
18male gamete generation (GO:0048232)5.42790022
19negative regulation of inclusion body assembly (GO:0090084)5.37148286
20DNA methylation involved in gamete generation (GO:0043046)5.11984034
21cell recognition (GO:0008037)5.10000767
22microtubule severing (GO:0051013)5.04610631
23cellular process involved in reproduction in multicellular organism (GO:0022412)5.04312657
24gamete generation (GO:0007276)5.00150146
25male meiosis I (GO:0007141)4.97713909
26organic cation transport (GO:0015695)4.95700934
27spermatid nucleus differentiation (GO:0007289)4.94135780
28chromosome organization involved in meiosis (GO:0070192)4.93790137
29regulation of microtubule-based movement (GO:0060632)4.85169543
30germ cell development (GO:0007281)4.81071730
31calcium ion-dependent exocytosis (GO:0017156)4.70900020
32microtubule depolymerization (GO:0007019)4.62141141
33meiotic nuclear division (GO:0007126)4.60232614
34intraciliary transport (GO:0042073)4.59757834
35protein polyglutamylation (GO:0018095)4.52264912
36axoneme assembly (GO:0035082)4.47452153
37regulation of inclusion body assembly (GO:0090083)4.46470818
38microtubule bundle formation (GO:0001578)4.38420044
39protein localization to cilium (GO:0061512)4.27059802
40left/right pattern formation (GO:0060972)4.08011046
41meiosis I (GO:0007127)3.97796454
42monoubiquitinated protein deubiquitination (GO:0035520)3.97368900
43multicellular organismal reproductive process (GO:0048609)3.93431829
44photoreceptor cell maintenance (GO:0045494)3.89975067
45neural tube formation (GO:0001841)3.80341692
46cilium organization (GO:0044782)3.77953840
47seminiferous tubule development (GO:0072520)3.75295809
48nonmotile primary cilium assembly (GO:0035058)3.74617276
49microtubule-based movement (GO:0007018)3.65469537
50cell projection assembly (GO:0030031)3.64927675
51cilium assembly (GO:0042384)3.60011357
52centriole assembly (GO:0098534)3.58777793
53cilium morphogenesis (GO:0060271)3.50445345
54genitalia morphogenesis (GO:0035112)3.49758640
55meiotic cell cycle (GO:0051321)3.49329375
56cellular component assembly involved in morphogenesis (GO:0010927)3.48235611
57GTP biosynthetic process (GO:0006183)3.46247256
58nucleoside diphosphate phosphorylation (GO:0006165)3.45409643
59centriole replication (GO:0007099)3.40500033
60smoothened signaling pathway (GO:0007224)3.35759870
61chaperone-mediated protein complex assembly (GO:0051131)3.32179498
62glycerol ether metabolic process (GO:0006662)3.29078744
63retinal cone cell development (GO:0046549)3.21132162
64one-carbon compound transport (GO:0019755)3.19718639
65regulation of centriole replication (GO:0046599)3.18752707
66detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.15409615
67multicellular organismal development (GO:0007275)3.14809095
68indole-containing compound catabolic process (GO:0042436)3.13378192
69indolalkylamine catabolic process (GO:0046218)3.13378192
70tryptophan catabolic process (GO:0006569)3.13378192
71gene silencing by RNA (GO:0031047)3.10638394
72determination of left/right symmetry (GO:0007368)3.10614794
73regulation of collateral sprouting (GO:0048670)3.09723459
74limb development (GO:0060173)3.09068639
75appendage development (GO:0048736)3.09068639
76vitamin transmembrane transport (GO:0035461)3.09054946
77synapsis (GO:0007129)3.08121442
78UTP biosynthetic process (GO:0006228)3.05854630
79ether metabolic process (GO:0018904)3.03290835
80left/right axis specification (GO:0070986)3.02570790
81indolalkylamine metabolic process (GO:0006586)3.00063206
82negative regulation of organelle assembly (GO:1902116)2.98965877
83determination of bilateral symmetry (GO:0009855)2.96198525
84carnitine transport (GO:0015879)2.93228302
85amino-acid betaine transport (GO:0015838)2.93228302
86behavioral response to nicotine (GO:0035095)2.90779349
87carnitine transmembrane transport (GO:1902603)2.90586169
88negative regulation of cytosolic calcium ion concentration (GO:0051481)2.89860277
89kynurenine metabolic process (GO:0070189)2.89748213
90lactate metabolic process (GO:0006089)2.89206758
91lateral ventricle development (GO:0021670)2.87339810
92specification of symmetry (GO:0009799)2.87335462
93protein K11-linked deubiquitination (GO:0035871)2.87125054
94cornea development in camera-type eye (GO:0061303)2.84704376
95detection of light stimulus involved in visual perception (GO:0050908)2.79313760
96detection of light stimulus involved in sensory perception (GO:0050962)2.79313760
97benzene-containing compound metabolic process (GO:0042537)2.79068712
98UTP metabolic process (GO:0046051)2.78504569
99protein refolding (GO:0042026)2.75605251
100peptidyl-glutamic acid modification (GO:0018200)2.75002011
101meiotic cell cycle process (GO:1903046)2.73808254
102L-fucose metabolic process (GO:0042354)2.72158254
103L-fucose catabolic process (GO:0042355)2.72158254
104fucose catabolic process (GO:0019317)2.72158254
105spinal cord motor neuron differentiation (GO:0021522)2.71461012
106drug catabolic process (GO:0042737)2.67276266
107primary alcohol catabolic process (GO:0034310)2.65380118
108cellular ketone body metabolic process (GO:0046950)2.64800488
109polyol catabolic process (GO:0046174)2.63434269
110signal peptide processing (GO:0006465)2.63014505
111exogenous drug catabolic process (GO:0042738)2.60246863
112regulation of spindle checkpoint (GO:0090231)2.59673119
113behavioral response to ethanol (GO:0048149)2.59666888
114positive regulation of macrophage activation (GO:0043032)2.58809011
115nuclear pore complex assembly (GO:0051292)2.58568174
116pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.57734119
117tryptophan metabolic process (GO:0006568)2.52719898
118retinal rod cell development (GO:0046548)2.52393176
119thyroid hormone metabolic process (GO:0042403)2.51962972
120transmission of nerve impulse (GO:0019226)2.50008534
121inner ear receptor stereocilium organization (GO:0060122)2.50000354
122alditol metabolic process (GO:0019400)2.49849592
123chromosome condensation (GO:0030261)2.48787497
124calcium ion import (GO:0070509)2.48025368
125peptidyl-lysine dimethylation (GO:0018027)2.47154649
126positive regulation of oligodendrocyte differentiation (GO:0048714)2.46217281
127photoreceptor cell development (GO:0042461)2.44893332
128reflex (GO:0060004)2.44003666
129negative regulation of B cell mediated immunity (GO:0002713)2.42657828
130negative regulation of immunoglobulin mediated immune response (GO:0002890)2.42657828
131diterpenoid biosynthetic process (GO:0016102)2.42171321
132negative regulation of T cell differentiation in thymus (GO:0033085)2.41379466
133retinoic acid metabolic process (GO:0042573)2.40665151
134microtubule polymerization or depolymerization (GO:0031109)2.39375839
135cytoplasmic microtubule organization (GO:0031122)2.38523700
136ketone body metabolic process (GO:1902224)2.38169456
137guanosine-containing compound biosynthetic process (GO:1901070)2.37767174
138single-organism membrane fusion (GO:0044801)2.36971671
139organelle assembly (GO:0070925)2.36670096
140establishment of protein localization to Golgi (GO:0072600)2.35695949
141DNA packaging (GO:0006323)2.35223977
142nucleus organization (GO:0006997)2.34364429
143neuronal action potential (GO:0019228)2.32053489
144microtubule-based process (GO:0007017)2.29878623
145glutathione derivative metabolic process (GO:1901685)2.29754963
146glutathione derivative biosynthetic process (GO:1901687)2.29754963
147tachykinin receptor signaling pathway (GO:0007217)2.28020524
148embryonic epithelial tube formation (GO:0001838)2.27886953
149indole-containing compound metabolic process (GO:0042430)2.27884969
150central nervous system neuron axonogenesis (GO:0021955)2.25917830
151gamma-aminobutyric acid transport (GO:0015812)2.25884656
152eye photoreceptor cell development (GO:0042462)2.25058340
153ethanol metabolic process (GO:0006067)2.24521866
154retina layer formation (GO:0010842)2.24063967
155regulation of hippo signaling (GO:0035330)2.21188826
156brain morphogenesis (GO:0048854)2.19804263
157auditory behavior (GO:0031223)2.19528878
158positive regulation of smoothened signaling pathway (GO:0045880)2.18735509
159regulation of smoothened signaling pathway (GO:0008589)2.17670316
160regulation of interleukin-5 production (GO:0032674)2.17035937
161cilium or flagellum-dependent cell motility (GO:0001539)15.4430923
162fusion of sperm to egg plasma membrane (GO:0007342)13.9605575
163cell wall macromolecule metabolic process (GO:0044036)13.1584874
164cell wall macromolecule catabolic process (GO:0016998)13.1584874
165acrosome assembly (GO:0001675)12.7865509
166multicellular organism reproduction (GO:0032504)12.3122120
167sperm-egg recognition (GO:0035036)11.6640824
168axonemal dynein complex assembly (GO:0070286)11.6074155
169sperm motility (GO:0030317)11.3707925
170plasma membrane fusion (GO:0045026)10.6131811
171cell-cell recognition (GO:0009988)10.4428056
172epithelial cilium movement (GO:0003351)10.3060497

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.40819241
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.70353376
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.47889151
4EZH2_22144423_ChIP-Seq_EOC_Human3.47423278
5GBX2_23144817_ChIP-Seq_PC3_Human3.18702643
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.75091825
7ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.74444174
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.66116899
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.53098574
10IGF1R_20145208_ChIP-Seq_DFB_Human2.46160279
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.25502973
12* PCGF2_27294783_Chip-Seq_ESCs_Mouse2.22894768
13* FLI1_27457419_Chip-Seq_LIVER_Mouse2.22337545
14PIAS1_25552417_ChIP-Seq_VCAP_Human2.21316239
15CBX2_27304074_Chip-Seq_ESCs_Mouse2.20762236
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.14260440
17FUS_26573619_Chip-Seq_HEK293_Human2.13625440
18ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.05655156
19KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse2.05072618
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.04654502
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.03646370
22CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02213880
23AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.02204027
24P300_19829295_ChIP-Seq_ESCs_Human2.01979097
25ZNF274_21170338_ChIP-Seq_K562_Hela1.98387198
26EWS_26573619_Chip-Seq_HEK293_Human1.98336408
27EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.97554412
28TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.97531385
29SMAD4_21799915_ChIP-Seq_A2780_Human1.96889316
30RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.93353169
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.93183960
32VDR_22108803_ChIP-Seq_LS180_Human1.92103170
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.86316926
34NR3C1_21868756_ChIP-Seq_MCF10A_Human1.86227029
35STAT3_23295773_ChIP-Seq_U87_Human1.85800248
36CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.84855671
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.84572848
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.84510305
39KAP1_22055183_ChIP-Seq_ESCs_Mouse1.82854837
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.75149851
41ELK4_26923725_Chip-Seq_MESODERM_Mouse1.72839559
42BCAT_22108803_ChIP-Seq_LS180_Human1.70584380
43DROSHA_22980978_ChIP-Seq_HELA_Human1.69580659
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.67869345
45GATA1_26923725_Chip-Seq_HPCs_Mouse1.66240096
46GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.65905066
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.64509200
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.62384807
49TAL1_26923725_Chip-Seq_HPCs_Mouse1.61150537
50FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.57936875
51FLI1_21867929_ChIP-Seq_TH2_Mouse1.57817299
52* NFE2_27457419_Chip-Seq_LIVER_Mouse1.56626579
53* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.55766799
54AR_25329375_ChIP-Seq_VCAP_Human1.55493508
55CBP_20019798_ChIP-Seq_JUKART_Human1.54089980
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.54089980
57* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.53956345
58STAT1_17558387_ChIP-Seq_HELA_Human1.53374501
59RNF2_27304074_Chip-Seq_NSC_Mouse1.53121111
60* KDM2B_26808549_Chip-Seq_REH_Human1.50702963
61AR_21572438_ChIP-Seq_LNCaP_Human1.47547813
62* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47180044
63WDR5_24793694_ChIP-Seq_LNCAP_Human1.46599692
64STAT6_21828071_ChIP-Seq_BEAS2B_Human1.43361594
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42275748
66TCF4_22108803_ChIP-Seq_LS180_Human1.41686834
67* NANOG_18555785_Chip-Seq_ESCs_Mouse1.40434947
68* OCT4_18555785_Chip-Seq_ESCs_Mouse1.39355761
69* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.39273909
70* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38799967
71RUNX2_22187159_ChIP-Seq_PCA_Human1.37324788
72MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.36914431
73* CRX_20693478_ChIP-Seq_RETINA_Mouse1.36347192
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.36029139
75AHR_22903824_ChIP-Seq_MCF-7_Human1.34734397
76LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.33609019
77GATA3_21867929_ChIP-Seq_CD8_Mouse1.32842214
78FOXM1_26456572_ChIP-Seq_MCF-7_Human1.31775008
79* EZH2_27294783_Chip-Seq_NPCs_Mouse1.31547802
80TP53_16413492_ChIP-PET_HCT116_Human1.29982296
81* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29785197
82* CMYC_18555785_Chip-Seq_ESCs_Mouse1.29247108
83* P300_18555785_Chip-Seq_ESCs_Mouse1.28771445
84* P53_22387025_ChIP-Seq_ESCs_Mouse1.27939525
85MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27077650
86* KLF4_18555785_Chip-Seq_ESCs_Mouse1.26733347
87SMAD4_21741376_ChIP-Seq_EPCs_Human1.25944447
88KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25635928
89TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25597043
90* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.25459360
91* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.25415369
92* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.24666131
93BMI1_23680149_ChIP-Seq_NPCS_Mouse1.23646269
94TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.23588903
95GATA3_21867929_ChIP-Seq_TH1_Mouse1.23391938
96* STAT3_18555785_Chip-Seq_ESCs_Mouse1.21528708
97CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21486029
98SOX2_22085726_ChIP-Seq_NPCs_Mouse1.21446285
99* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20947230
100GF1_26923725_Chip-Seq_HPCs_Mouse1.20643922
101TP53_18474530_ChIP-ChIP_U2OS_Human1.19782930
102RUNX1_26923725_Chip-Seq_HPCs_Mouse1.19210873
103* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18634675
104* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.18133258
105PRDM14_20953172_ChIP-Seq_ESCs_Human1.16350720
106ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15830076
107MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14214475
108* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.13649452
109NANOG_19829295_ChIP-Seq_ESCs_Human1.13119551
110SOX2_19829295_ChIP-Seq_ESCs_Human1.13119551
111SOX2_21211035_ChIP-Seq_LN229_Gbm1.13016454
112* CTCF_18555785_Chip-Seq_ESCs_Mouse1.12996731
113* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.12968973
114* SOX2_18555785_Chip-Seq_ESCs_Mouse1.12489053
115CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12359001
116REST_21632747_ChIP-Seq_MESCs_Mouse1.09833439
117FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09823142
118FOXA1_25329375_ChIP-Seq_VCAP_Human1.09823142
119FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09734184
120* CDX2_22108803_ChIP-Seq_LS180_Human1.09717060
121GF1B_26923725_Chip-Seq_HPCs_Mouse1.08067276
122* E2F1_18555785_Chip-Seq_ESCs_Mouse1.06556427
123PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.06353522
124TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05620357
125TBL1_22424771_ChIP-Seq_293T_Human1.05073343
126ETV1_20927104_ChIP-Seq_GIST48_Human1.04618799
127TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04303557
128POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04303557
129SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.04152401
130* ZFX_18555785_Chip-Seq_ESCs_Mouse1.03784188
131* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.03288464
132EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01476090
133* PU1_27457419_Chip-Seq_LIVER_Mouse1.01049709
134TP53_22573176_ChIP-Seq_HFKS_Human1.00789285
135ER_23166858_ChIP-Seq_MCF-7_Human0.99642550
136PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.99629772
137RXR_22108803_ChIP-Seq_LS180_Human0.99533879
138CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98645510
139* NMYC_18555785_Chip-Seq_ESCs_Mouse0.98389690
140NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.98185787
141GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97850857
142JUN_21703547_ChIP-Seq_K562_Human0.97050598
143SPI1_26923725_Chip-Seq_HPCs_Mouse0.96387039
144PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93484984
145* P53_21459846_ChIP-Seq_SAOS-2_Human0.93262706
146SOX9_26525672_Chip-Seq_HEART_Mouse0.92509124
147CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90106971
148PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.89072799
149* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.88873609
150TCF4_23295773_ChIP-Seq_U87_Human0.88522679
151STAT3_18555785_ChIP-Seq_MESCs_Mouse0.87744482
152* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.87637721
153TAF15_26573619_Chip-Seq_HEK293_Human0.87154619
154FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86757614
155RAD21_21589869_ChIP-Seq_MESCs_Mouse0.86363422
156NFYB_21822215_ChIP-Seq_K562_Human0.85687526
157EP300_21415370_ChIP-Seq_HL-1_Mouse0.85562576
158ESET_19884257_ChIP-Seq_ESCs_Mouse0.84946666

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.89279037
2MP0001929_abnormal_gametogenesis5.36461457
3MP0002653_abnormal_ependyma_morphology4.85655643
4MP0008877_abnormal_DNA_methylation4.81794502
5MP0002210_abnormal_sex_determination3.62339013
6MP0005623_abnormal_meninges_morphology3.51372173
7MP0002161_abnormal_fertility/fecundity3.13092026
8MP0001145_abnormal_male_reproductive3.08234375
9MP0008875_abnormal_xenobiotic_pharmacok3.01853713
10MP0003136_yellow_coat_color2.79382506
11MP0000653_abnormal_sex_gland2.70297567
12MP0003195_calcinosis2.14994464
13MP0000383_abnormal_hair_follicle2.07365696
14MP0000569_abnormal_digit_pigmentation2.01296388
15MP0005410_abnormal_fertilization14.8034071
16MP0003880_abnormal_central_pattern1.94933828
17MP0005670_abnormal_white_adipose1.92902810
18MP0006276_abnormal_autonomic_nervous1.88506271
19MP0008789_abnormal_olfactory_epithelium1.80635921
20MP0001984_abnormal_olfaction1.80065472
21MP0002282_abnormal_trachea_morphology1.76092511
22MP0001968_abnormal_touch/_nociception1.74127405
23MP0002736_abnormal_nociception_after1.70398557
24MP0001486_abnormal_startle_reflex1.66121850
25MP0001485_abnormal_pinna_reflex1.66023969
26MP0008057_abnormal_DNA_replication1.64489402
27MP0002160_abnormal_reproductive_system1.58054476
28MP0002638_abnormal_pupillary_reflex1.54823126
29* MP0009745_abnormal_behavioral_response1.54644054
30MP0004233_abnormal_muscle_weight1.52687095
31MP0010386_abnormal_urinary_bladder1.51751661
32MP0002734_abnormal_mechanical_nocicepti1.51005980
33MP0000566_synostosis1.47742431
34MP0002938_white_spotting1.41774085
35MP0002735_abnormal_chemical_nociception1.41752576
36MP0002272_abnormal_nervous_system1.38811229
37MP0008058_abnormal_DNA_repair1.35345579
38MP0001501_abnormal_sleep_pattern1.35154170
39MP0000778_abnormal_nervous_system1.31556127
40MP0005394_taste/olfaction_phenotype1.30792330
41MP0005499_abnormal_olfactory_system1.30792330
42MP0004142_abnormal_muscle_tone1.26384286
43MP0010678_abnormal_skin_adnexa1.23452293
44MP0009780_abnormal_chondrocyte_physiolo1.23017307
45MP0000372_irregular_coat_pigmentation1.21463786
46MP0002876_abnormal_thyroid_physiology1.20850682
47MP0001970_abnormal_pain_threshold1.19358118
48MP0003937_abnormal_limbs/digits/tail_de1.19307004
49MP0003646_muscle_fatigue1.17300323
50MP0000026_abnormal_inner_ear1.17069317
51MP0002822_catalepsy1.16910249
52MP0005171_absent_coat_pigmentation1.16344469
53MP0002277_abnormal_respiratory_mucosa1.16255816
54MP0004885_abnormal_endolymph1.16244286
55MP0001529_abnormal_vocalization1.15319736
56MP0008872_abnormal_physiological_respon1.15245071
57MP0005645_abnormal_hypothalamus_physiol1.14377793
58MP0003950_abnormal_plasma_membrane1.12965794
59MP0003252_abnormal_bile_duct1.10534703
60MP0002067_abnormal_sensory_capabilities1.10501921
61MP0005647_abnormal_sex_gland1.09414797
62MP0002928_abnormal_bile_duct1.07628609
63MP0005083_abnormal_biliary_tract1.06837941
64MP0003787_abnormal_imprinting1.06120881
65MP0001765_abnormal_ion_homeostasis1.04382221
66MP0005085_abnormal_gallbladder_physiolo1.02574603
67MP0002752_abnormal_somatic_nervous1.01713997
68MP0003890_abnormal_embryonic-extraembry1.01673490
69* MP0002064_seizures1.01353948
70MP0005187_abnormal_penis_morphology0.97736497
71MP0001963_abnormal_hearing_physiology0.97418087
72MP0003635_abnormal_synaptic_transmissio0.96163380
73MP0002132_abnormal_respiratory_system0.96095293
74MP0000955_abnormal_spinal_cord0.95663127
75MP0002882_abnormal_neuron_morphology0.91796696
76MP0002233_abnormal_nose_morphology0.91328504
77MP0002063_abnormal_learning/memory/cond0.90946572
78MP0003718_maternal_effect0.90262830
79MP0004924_abnormal_behavior0.89900301
80MP0005386_behavior/neurological_phenoty0.89900301
81MP0006292_abnormal_olfactory_placode0.89214311
82MP0005395_other_phenotype0.86854709
83MP0005389_reproductive_system_phenotype0.86792501
84* MP0009046_muscle_twitch0.85790087
85MP0002184_abnormal_innervation0.83538924
86MP0002234_abnormal_pharynx_morphology0.83267847
87MP0005248_abnormal_Harderian_gland0.80420966
88MP0005174_abnormal_tail_pigmentation0.79647537
89MP0004133_heterotaxia0.72500742
90MP0005551_abnormal_eye_electrophysiolog0.65497459
91MP0010094_abnormal_chromosome_stability0.62194250
92MP0005253_abnormal_eye_physiology0.61595515
93MP0004134_abnormal_chest_morphology0.61437863
94MP0010307_abnormal_tumor_latency0.60866828
95MP0008995_early_reproductive_senescence0.60316537
96MP0003011_delayed_dark_adaptation0.59656855
97MP0009697_abnormal_copulation0.58540230
98MP0003786_premature_aging0.57146712
99MP0008007_abnormal_cellular_replicative0.55393001
100MP0000427_abnormal_hair_cycle0.53279422
101MP0004036_abnormal_muscle_relaxation0.51239755
102MP0003699_abnormal_female_reproductive0.50758514
103MP0002102_abnormal_ear_morphology0.49324865
104MP0002837_dystrophic_cardiac_calcinosis0.47543786
105MP0000013_abnormal_adipose_tissue0.46947040
106MP0003183_abnormal_peptide_metabolism0.45722576
107MP0001324_abnormal_eye_pigmentation0.45592750
108MP0005636_abnormal_mineral_homeostasis0.44765896
109MP0001293_anophthalmia0.44102018
110MP0005391_vision/eye_phenotype0.42857560
111MP0003115_abnormal_respiratory_system0.40545538
112MP0003878_abnormal_ear_physiology0.40347328
113MP0005377_hearing/vestibular/ear_phenot0.40347328
114MP0006072_abnormal_retinal_apoptosis0.39917270
115MP0001119_abnormal_female_reproductive0.39685959
116MP0000432_abnormal_head_morphology0.39394896
117MP0000358_abnormal_cell_content/0.38629322
118MP0005646_abnormal_pituitary_gland0.38064340
119MP0003861_abnormal_nervous_system0.35390215
120MP0003045_fibrosis0.34163119
121MP0001270_distended_abdomen0.33325584
122MP0004043_abnormal_pH_regulation0.33173065
123MP0005388_respiratory_system_phenotype0.31848669
124MP0002133_abnormal_respiratory_system0.31848669
125MP0002108_abnormal_muscle_morphology0.31269245
126MP0001661_extended_life_span0.31220085
127MP0005666_abnormal_adipose_tissue0.30048770
128MP0002269_muscular_atrophy0.29996842
129MP0003634_abnormal_glial_cell0.29023456
130MP0002971_abnormal_brown_adipose0.28972565
131MP0003942_abnormal_urinary_system0.28387283
132MP0004019_abnormal_vitamin_homeostasis0.28357555
133MP0002009_preneoplasia0.28033525
134MP0001986_abnormal_taste_sensitivity0.27997326
135MP0005195_abnormal_posterior_eye0.27471362
136MP0000631_abnormal_neuroendocrine_gland0.26576367
137MP0004145_abnormal_muscle_electrophysio0.25670534
138MP0002084_abnormal_developmental_patter0.25636480
139MP0003943_abnormal_hepatobiliary_system0.25497945
140MP0004084_abnormal_cardiac_muscle0.24986673
141MP0005503_abnormal_tendon_morphology0.24905037
142* MP0002152_abnormal_brain_morphology0.24895820
143MP0009115_abnormal_fat_cell0.23944054
144MP0009250_abnormal_appendicular_skeleto0.22740338
145MP0002116_abnormal_craniofacial_bone0.22166942
146MP0002168_other_aberrant_phenotype0.22137366
147MP0006138_congestive_heart_failure0.22100742
148MP0005397_hematopoietic_system_phenotyp0.21880394
149MP0001545_abnormal_hematopoietic_system0.21880394
150MP0002693_abnormal_pancreas_physiology0.21477267
151MP0004811_abnormal_neuron_physiology0.21463899
152MP0001944_abnormal_pancreas_morphology0.21298223
153MP0001299_abnormal_eye_distance/0.21235475
154MP0000647_abnormal_sebaceous_gland0.20157778
155MP0004808_abnormal_hematopoietic_stem0.19824290
156MP0002229_neurodegeneration0.18989976
157MP0002909_abnormal_adrenal_gland0.18826834
158MP0001730_embryonic_growth_arrest0.18354859
159MP0002557_abnormal_social/conspecific_i0.18160122
160MP0003329_amyloid_beta_deposits0.18157798
161MP0001851_eye_inflammation0.17988549
162MP0002572_abnormal_emotion/affect_behav0.17930642
163MP0004272_abnormal_basement_membrane0.17508249

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)8.69996481
2Abnormal respiratory epithelium morphology (HP:0012253)8.69996481
3Rhinitis (HP:0012384)8.68552579
4Abnormal ciliary motility (HP:0012262)8.68418416
5Chronic bronchitis (HP:0004469)7.78155132
6Nasal polyposis (HP:0100582)6.24086335
7Infertility (HP:0000789)5.31747654
8Abnormality of the nasal mucosa (HP:0000433)5.17956535
9Bronchiectasis (HP:0002110)5.06152402
10Bronchitis (HP:0012387)4.77661798
11Nephronophthisis (HP:0000090)4.28478625
12Recurrent sinusitis (HP:0011108)3.58811567
13Medial flaring of the eyebrow (HP:0010747)3.39217325
14Recurrent otitis media (HP:0000403)3.37216649
15Abnormality of the renal medulla (HP:0100957)3.25773874
16Molar tooth sign on MRI (HP:0002419)3.17157383
17Abnormality of midbrain morphology (HP:0002418)3.17157383
18Male infertility (HP:0003251)3.16310261
19Anencephaly (HP:0002323)2.81170589
20Recurrent bronchitis (HP:0002837)2.77332909
21Abnormal spermatogenesis (HP:0008669)2.77300328
22Sclerocornea (HP:0000647)2.77068868
23Tubulointerstitial nephritis (HP:0001970)2.75529231
24Tubular atrophy (HP:0000092)2.68729955
25Pancreatic fibrosis (HP:0100732)2.59471768
26Male pseudohermaphroditism (HP:0000037)2.55852611
27Furrowed tongue (HP:0000221)2.50115177
28Chronic sinusitis (HP:0011109)2.47245861
29Tubulointerstitial abnormality (HP:0001969)2.42905308
30Congenital primary aphakia (HP:0007707)2.42506715
31Gait imbalance (HP:0002141)2.41874828
32Hyperventilation (HP:0002883)2.36276886
33Postaxial foot polydactyly (HP:0001830)2.35588314
34Congenital hepatic fibrosis (HP:0002612)2.29920951
35Median cleft lip (HP:0000161)2.29071481
36Fibular hypoplasia (HP:0003038)2.27854307
37Genetic anticipation (HP:0003743)2.27055159
38Progressive cerebellar ataxia (HP:0002073)2.24539641
39Microglossia (HP:0000171)2.15390616
40Azoospermia (HP:0000027)2.13990296
41Chronic otitis media (HP:0000389)2.12568185
42Nephrogenic diabetes insipidus (HP:0009806)2.10011194
43Tongue fasciculations (HP:0001308)2.08128251
44Abnormality of dentin (HP:0010299)2.07988734
45Tubulointerstitial fibrosis (HP:0005576)2.06391139
46Facial cleft (HP:0002006)2.05034803
47Gaze-evoked nystagmus (HP:0000640)2.04871065
48Abnormality of the lower motor neuron (HP:0002366)2.02846914
49Aplasia/Hypoplasia of the tongue (HP:0010295)2.01352619
50Respiratory insufficiency due to defective ciliary clearance (HP:0200073)14.8064721
51Dynein arm defect of respiratory motile cilia (HP:0012255)11.5270953
52Absent/shortened dynein arms (HP:0200106)11.5270953
53Abnormal respiratory motile cilium physiology (HP:0012261)10.2945537
54Absent speech (HP:0001344)1.97977177
55Postaxial hand polydactyly (HP:0001162)1.94174383
56Genital tract atresia (HP:0001827)1.93207135
57Polydipsia (HP:0001959)1.93195102
58Abnormal drinking behavior (HP:0030082)1.93195102
59Abnormality of macular pigmentation (HP:0008002)1.92940445
60Cystic liver disease (HP:0006706)1.92189086
61Stage 5 chronic kidney disease (HP:0003774)1.91801819
62Muscle fibrillation (HP:0010546)1.90902329
63True hermaphroditism (HP:0010459)1.88681913
64Decreased circulating renin level (HP:0003351)1.87546540
65Abnormality of the renal cortex (HP:0011035)1.82321125
66Retinitis pigmentosa (HP:0000510)1.82127472
67Short ribs (HP:0000773)1.82103749
68Aplasia/Hypoplasia of the spleen (HP:0010451)1.81833665
69Gonadotropin excess (HP:0000837)1.80045887
70Vaginal atresia (HP:0000148)1.78426803
71Abolished electroretinogram (ERG) (HP:0000550)1.77700347
72Poor coordination (HP:0002370)1.76212366
73Bony spicule pigmentary retinopathy (HP:0007737)1.75650304
74Renal dysplasia (HP:0000110)1.74363261
75Congenital stationary night blindness (HP:0007642)1.74326929
76Abnormality of the dental root (HP:0006486)1.70871356
77Taurodontia (HP:0000679)1.70871356
78Abnormality of permanent molar morphology (HP:0011071)1.70871356
79Chronic hepatic failure (HP:0100626)1.70534663
80Aplasia/Hypoplasia of the lens (HP:0008063)1.69472840
81Broad foot (HP:0001769)1.69128747
82Oculomotor apraxia (HP:0000657)1.69061090
83Supernumerary spleens (HP:0009799)1.69010662
84Aplasia/Hypoplasia of the tibia (HP:0005772)1.68816615
85Absent frontal sinuses (HP:0002688)1.67676181
86Amyotrophic lateral sclerosis (HP:0007354)1.66602488
87Narrow forehead (HP:0000341)1.64741171
88Occipital encephalocele (HP:0002085)1.64191264
89Bile duct proliferation (HP:0001408)1.63907521
90Abnormal biliary tract physiology (HP:0012439)1.63907521
91Asplenia (HP:0001746)1.63220147
92Attenuation of retinal blood vessels (HP:0007843)1.62870657
93Pancreatic cysts (HP:0001737)1.62772147
94Abnormality of molar (HP:0011077)1.62580495
95Abnormality of molar morphology (HP:0011070)1.62580495
96Abnormality of the dental pulp (HP:0006479)1.61994346
97Prominent nasal bridge (HP:0000426)1.61513794
98Aganglionic megacolon (HP:0002251)1.60606080
99Highly arched eyebrow (HP:0002553)1.60294490
100Impulsivity (HP:0100710)1.57318783
101Atelectasis (HP:0100750)1.57226358
102Abnormality of saccadic eye movements (HP:0000570)1.54549182
103Hyperactive renin-angiotensin system (HP:0000841)1.53864612
104Abnormality of renal excretion (HP:0011036)1.53726778
105J-shaped sella turcica (HP:0002680)1.53663106
106Absent rod-and cone-mediated responses on ERG (HP:0007688)1.53074226
107Short foot (HP:0001773)1.52925655
108Multicystic kidney dysplasia (HP:0000003)1.52893233
109Specific learning disability (HP:0001328)1.50778228
110Central scotoma (HP:0000603)1.48815072
111Abnormality of ocular smooth pursuit (HP:0000617)1.48313466
112Abnormal rod and cone electroretinograms (HP:0008323)1.48303537
113Widely spaced teeth (HP:0000687)1.45510155
114Aplasia/Hypoplasia of the fibula (HP:0006492)1.44042798
115Bell-shaped thorax (HP:0001591)1.43747041
116Short thorax (HP:0010306)1.43488328
117Astigmatism (HP:0000483)1.41501461
118Left ventricular hypertrophy (HP:0001712)1.41443183
119Broad-based gait (HP:0002136)1.40971312
120Decreased central vision (HP:0007663)1.40800640
121Dandy-Walker malformation (HP:0001305)1.39446914
122Type II lissencephaly (HP:0007260)1.39267811
123Impaired proprioception (HP:0010831)1.39224461
124Increased corneal curvature (HP:0100692)1.39126488
125Keratoconus (HP:0000563)1.39126488
126Hypoplasia of the capital femoral epiphysis (HP:0003090)1.38756110
127Decreased testicular size (HP:0008734)1.37633209
128Nephropathy (HP:0000112)1.37318796
129Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.33366138
130Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.31992236
131Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.31198459
132Optic nerve hypoplasia (HP:0000609)1.30402433
133Abnormal urine output (HP:0012590)1.25032369
134Breast carcinoma (HP:0003002)1.24130105
13511 pairs of ribs (HP:0000878)1.22195860
136Preaxial hand polydactyly (HP:0001177)1.21103750
137Limb ataxia (HP:0002070)1.20513152
138Polyuria (HP:0000103)1.16766163
139Impaired smooth pursuit (HP:0007772)1.16523637
140Deformed sella turcica (HP:0002681)1.15608025
141Pachygyria (HP:0001302)1.14862076
142Heterotopia (HP:0002282)1.14383552

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.67167796
2PDK48.67167796
3PDK25.54055206
4TESK14.25868039
5PRKD33.58686674
6WNK42.82287186
7PTK2B2.75468042
8ICK2.74468727
9STK392.69440303
10PNCK2.56626527
11CASK2.37497147
12MAPK152.29976257
13MAP4K22.16514493
14ACVR1B2.00403600
15ADRBK21.97972773
16BCR1.95515421
17MST41.88988004
18MAPK131.79171621
19EPHA31.59356616
20NEK21.43135467
21STK381.36100666
22ZAK1.30563705
23MARK11.30146545
24LMTK21.29971069
25NTRK31.28146809
26STK38L1.25206896
27TRIM281.21455897
28ERBB31.19807853
29MKNK21.18648734
30WEE11.14821660
31WNK11.12891580
32PASK1.06304701
33EPHA41.03427171
34ADRBK11.02707747
35TLK11.01647803
36PLK20.99036795
37NUAK10.96991941
38TNIK0.96361817
39PAK30.95838912
40MAP3K70.95706188
41PRKCE0.94915467
42STK30.94472981
43DYRK1B0.92807254
44PDK10.90639834
45CDK190.89437360
46TYRO30.89111143
47CSNK1G20.89099519
48FER0.88702024
49CSNK1A1L0.83798145
50BRSK20.82980070
51MAPKAPK30.81760223
52ERBB20.80368758
53IRAK10.79808035
54AKT30.76507781
55CCNB10.75328625
56TAOK30.75056270
57FRK0.73791733
58TGFBR10.73683502
59PLK40.72638836
60CSNK1G10.68674247
61DYRK20.68371466
62CHEK20.67061849
63DYRK30.65217673
64CSNK1G30.64563142
65NME10.63002832
66MAP2K70.60487922
67DYRK1A0.59977327
68WNK30.56579451
69CAMKK20.55938345
70NEK60.55647489
71EPHA20.54672964
72NLK0.52549734
73SGK20.52460982
74TRPM70.51674859
75MKNK10.51629116
76CDK120.51354392
77PIK3CA0.50489565
78MAP2K40.50136108
79DAPK20.47170519
80TTK0.47054163
81CHEK10.46988321
82PRKAA20.45755128
83SGK4940.42951537
84SGK2230.42951537
85CAMK1G0.41722143
86TEC0.39853995
87CDC70.39474285
88ATR0.38236912
89PDPK10.37197238
90ATM0.36353578
91MAP3K20.35540224
92PINK10.35092371
93CHUK0.34399735
94MAP3K40.32728953
95BRSK10.32649464
96BMPR1B0.32348312
97VRK10.31713114
98CSNK1A10.31233172
99ZAP700.30805632
100TXK0.30588200
101PRKCG0.30447890
102PIK3CG0.30444818
103CAMK10.30341916
104PRKG20.29705943
105MAPKAPK50.28126697
106FGFR20.27992628
107MAP2K60.24380863
108PDGFRB0.24318705
109MTOR0.23608345
110EEF2K0.23417997
111STK240.23363715
112TESK20.23263674
113PAK20.23071420
114INSRR0.22549168
115PLK10.22548497
116STK100.22282685
117NTRK20.22160585
118RIPK10.20597273
119PRKAA10.20293547
120PAK10.20265057
121MARK30.18201267
122IRAK20.18176401
123PRKG10.18136767
124RPS6KB10.18025342
125MUSK0.17287199
126GRK10.16117463
127YES10.14662249
128LATS10.14583771
129PRKCQ0.13982558
130CSNK2A10.10744685
131PKN10.10508392
132CDK30.10244770
133PRKDC0.10133806
134CSNK2A20.09432649
135TGFBR20.08893670
136MARK20.08535464
137DDR20.08452536
138EGFR0.07222074
139STK110.07054411
140PRKACG0.06906962
141GSK3B0.06114197
142MAPK100.05857375
143AURKA0.05035048
144CDK10.04906437
145CAMKK10.03667436
146PTK60.03077118
147CAMK2A0.02833949
148INSR0.02653591
149PRKCZ0.02642751
150MAPK80.02628713
151CSNK1D0.01919473
152CDK150.01858971
153OXSR10.01715518
154SRC0.01238523
155PRKCA0.01202805
156PRKACA0.01003864
157CDK20.00859406

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007503.91863507
2Pyruvate metabolism_Homo sapiens_hsa006203.68208243
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.67234319
4Basal transcription factors_Homo sapiens_hsa030223.22170892
5Pentose phosphate pathway_Homo sapiens_hsa000303.17164564
6Propanoate metabolism_Homo sapiens_hsa006403.15054366
7Fatty acid biosynthesis_Homo sapiens_hsa000612.91086812
8Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.87613334
9Glucagon signaling pathway_Homo sapiens_hsa049222.66886948
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.54547205
11Phototransduction_Homo sapiens_hsa047442.50592307
12Nicotine addiction_Homo sapiens_hsa050332.45196716
13Histidine metabolism_Homo sapiens_hsa003402.42349666
14Butanoate metabolism_Homo sapiens_hsa006502.36960890
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.31946655
16Linoleic acid metabolism_Homo sapiens_hsa005912.26971870
17Huntingtons disease_Homo sapiens_hsa050162.25163057
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.18680835
19Glycosaminoglycan degradation_Homo sapiens_hsa005312.17447492
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.14067109
21Fanconi anemia pathway_Homo sapiens_hsa034602.12620303
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.10716513
23Primary bile acid biosynthesis_Homo sapiens_hsa001202.07535818
24Selenocompound metabolism_Homo sapiens_hsa004502.01912206
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.00266058
26Caffeine metabolism_Homo sapiens_hsa002321.89409352
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.89174442
28Nitrogen metabolism_Homo sapiens_hsa009101.87821060
29Dorso-ventral axis formation_Homo sapiens_hsa043201.86990431
30Renin-angiotensin system_Homo sapiens_hsa046141.86367548
31Oocyte meiosis_Homo sapiens_hsa041141.82483654
32beta-Alanine metabolism_Homo sapiens_hsa004101.79249910
33Glycerolipid metabolism_Homo sapiens_hsa005611.75289801
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.74351311
35Tryptophan metabolism_Homo sapiens_hsa003801.73287391
36Retinol metabolism_Homo sapiens_hsa008301.70861097
37Amphetamine addiction_Homo sapiens_hsa050311.58174789
38PPAR signaling pathway_Homo sapiens_hsa033201.55054516
39Carbohydrate digestion and absorption_Homo sapiens_hsa049731.53404730
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.44888182
41Renin secretion_Homo sapiens_hsa049241.43668473
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.42353303
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.41814695
44Carbon metabolism_Homo sapiens_hsa012001.36082394
45Glycerophospholipid metabolism_Homo sapiens_hsa005641.33656395
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.31838763
47Mineral absorption_Homo sapiens_hsa049781.30835056
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25872223
49Tyrosine metabolism_Homo sapiens_hsa003501.23209802
50Peroxisome_Homo sapiens_hsa041461.22217863
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.19423538
52Morphine addiction_Homo sapiens_hsa050321.17906288
53Ether lipid metabolism_Homo sapiens_hsa005651.17540156
54Serotonergic synapse_Homo sapiens_hsa047261.16793982
55Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.16459176
56Glutamatergic synapse_Homo sapiens_hsa047241.14846707
57Phenylalanine metabolism_Homo sapiens_hsa003601.12793740
58Fructose and mannose metabolism_Homo sapiens_hsa000511.12072547
59Cardiac muscle contraction_Homo sapiens_hsa042601.11439553
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.10565784
61GABAergic synapse_Homo sapiens_hsa047271.09191790
62Insulin secretion_Homo sapiens_hsa049111.08289354
63Purine metabolism_Homo sapiens_hsa002301.05740075
64mRNA surveillance pathway_Homo sapiens_hsa030151.03124148
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.99726680
66N-Glycan biosynthesis_Homo sapiens_hsa005100.98629659
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98061505
68Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.97200173
69Circadian rhythm_Homo sapiens_hsa047100.96376624
70Fat digestion and absorption_Homo sapiens_hsa049750.94240250
71Sphingolipid metabolism_Homo sapiens_hsa006000.94039385
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.92482553
73Biosynthesis of amino acids_Homo sapiens_hsa012300.92334240
74Antigen processing and presentation_Homo sapiens_hsa046120.92139014
75Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.87674066
76Glutathione metabolism_Homo sapiens_hsa004800.87642262
77RNA transport_Homo sapiens_hsa030130.86679770
78Regulation of autophagy_Homo sapiens_hsa041400.86378351
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82782299
80Taste transduction_Homo sapiens_hsa047420.82543396
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82305629
82Estrogen signaling pathway_Homo sapiens_hsa049150.79773702
83Ovarian steroidogenesis_Homo sapiens_hsa049130.78837603
84Thyroid hormone synthesis_Homo sapiens_hsa049180.78473175
85Fatty acid degradation_Homo sapiens_hsa000710.75962278
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75473886
87Lysine degradation_Homo sapiens_hsa003100.73920946
88Oxidative phosphorylation_Homo sapiens_hsa001900.73900515
89Fatty acid metabolism_Homo sapiens_hsa012120.73546870
90Basal cell carcinoma_Homo sapiens_hsa052170.72652921
91Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71529795
92Calcium signaling pathway_Homo sapiens_hsa040200.70005167
93ABC transporters_Homo sapiens_hsa020100.69267010
94cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67301141
95Chemical carcinogenesis_Homo sapiens_hsa052040.67141347
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.66830941
97Sulfur metabolism_Homo sapiens_hsa009200.66695760
98Dopaminergic synapse_Homo sapiens_hsa047280.66219955
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66027129
100Long-term potentiation_Homo sapiens_hsa047200.65583885
101Arachidonic acid metabolism_Homo sapiens_hsa005900.63426669
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62388938
103RNA polymerase_Homo sapiens_hsa030200.62083817
104Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60144559
105Steroid biosynthesis_Homo sapiens_hsa001000.58698592
106Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56676831
107Protein digestion and absorption_Homo sapiens_hsa049740.55764873
108Axon guidance_Homo sapiens_hsa043600.55467615
109Olfactory transduction_Homo sapiens_hsa047400.53941849
110Inositol phosphate metabolism_Homo sapiens_hsa005620.53178550
111Hedgehog signaling pathway_Homo sapiens_hsa043400.52705563
112Pancreatic secretion_Homo sapiens_hsa049720.51280528
113Starch and sucrose metabolism_Homo sapiens_hsa005000.50979393
114Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50377086
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.50092529
116Endocytosis_Homo sapiens_hsa041440.48277272
117Cocaine addiction_Homo sapiens_hsa050300.47668199
118Systemic lupus erythematosus_Homo sapiens_hsa053220.47368973
119AMPK signaling pathway_Homo sapiens_hsa041520.45955694
120Protein export_Homo sapiens_hsa030600.45622170
121Non-homologous end-joining_Homo sapiens_hsa034500.44066531
122Hippo signaling pathway_Homo sapiens_hsa043900.43208796
123Homologous recombination_Homo sapiens_hsa034400.42101295
124Bile secretion_Homo sapiens_hsa049760.41475079
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.40108141
126Adipocytokine signaling pathway_Homo sapiens_hsa049200.38792008
127Cholinergic synapse_Homo sapiens_hsa047250.38230822
128Metabolic pathways_Homo sapiens_hsa011000.38043505
129Long-term depression_Homo sapiens_hsa047300.37894376
130cAMP signaling pathway_Homo sapiens_hsa040240.37803110
131Collecting duct acid secretion_Homo sapiens_hsa049660.36697288
132Circadian entrainment_Homo sapiens_hsa047130.36392876
133Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35463494
134Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35275446
135Parkinsons disease_Homo sapiens_hsa050120.35239401
136Gastric acid secretion_Homo sapiens_hsa049710.34816322
137Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.34297028
138Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31285561
139Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.31008543
140Oxytocin signaling pathway_Homo sapiens_hsa049210.30574131
141Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30390664
142Wnt signaling pathway_Homo sapiens_hsa043100.27730151
143Tight junction_Homo sapiens_hsa045300.26795243
144Salivary secretion_Homo sapiens_hsa049700.25809961
145Viral carcinogenesis_Homo sapiens_hsa052030.25658114
146Synaptic vesicle cycle_Homo sapiens_hsa047210.24391646
147Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.24278928
148Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.23686518
149Aldosterone synthesis and secretion_Homo sapiens_hsa049250.21025919
150RNA degradation_Homo sapiens_hsa030180.20962264
151Alcoholism_Homo sapiens_hsa050340.19158348
152Cell cycle_Homo sapiens_hsa041100.18304316
153Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.16452274

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