EFCAB9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)9.87215209
2epithelial cilium movement (GO:0003351)9.76390325
3spermatid development (GO:0007286)9.05495034
4motile cilium assembly (GO:0044458)9.04366904
5cilium movement (GO:0003341)8.24867218
6single fertilization (GO:0007338)7.88305751
7regulation of cilium movement (GO:0003352)7.77258871
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.65811836
9male meiosis (GO:0007140)7.49942276
10sperm capacitation (GO:0048240)7.36754991
11synaptonemal complex assembly (GO:0007130)6.98184791
12synaptonemal complex organization (GO:0070193)6.95420617
13piRNA metabolic process (GO:0034587)6.74270034
14fertilization (GO:0009566)6.36401965
15microtubule depolymerization (GO:0007019)6.09231784
16spermatogenesis (GO:0007283)6.05756820
17male gamete generation (GO:0048232)6.03575155
18spermatid nucleus differentiation (GO:0007289)5.69774617
19negative regulation of inclusion body assembly (GO:0090084)5.68952989
20organic cation transport (GO:0015695)5.63191395
21gamete generation (GO:0007276)5.55215042
22ventricular system development (GO:0021591)5.42196096
23cell recognition (GO:0008037)5.36250570
24microtubule severing (GO:0051013)5.33113656
25cellular process involved in reproduction in multicellular organism (GO:0022412)5.26213199
26calcium ion-dependent exocytosis (GO:0017156)5.24356709
27germ cell development (GO:0007281)5.02117878
28chromosome organization involved in meiosis (GO:0070192)4.93374885
29regulation of inclusion body assembly (GO:0090083)4.81212843
30monoubiquitinated protein deubiquitination (GO:0035520)4.54939191
31glycerol ether metabolic process (GO:0006662)4.53381153
32regulation of microtubule-based movement (GO:0060632)4.47677477
33multicellular organismal reproductive process (GO:0048609)4.36336726
34DNA methylation involved in gamete generation (GO:0043046)4.35213681
35meiotic nuclear division (GO:0007126)4.21762768
36male meiosis I (GO:0007141)4.21005620
37ether metabolic process (GO:0018904)4.18124294
38seminiferous tubule development (GO:0072520)4.03476285
39chromosome condensation (GO:0030261)3.88136570
40chaperone-mediated protein complex assembly (GO:0051131)3.78994228
41protein K11-linked deubiquitination (GO:0035871)3.78037705
42protein polyglutamylation (GO:0018095)3.71203307
43DNA packaging (GO:0006323)3.65063707
44genitalia morphogenesis (GO:0035112)3.53542488
45multicellular organismal development (GO:0007275)3.51818124
46left/right pattern formation (GO:0060972)3.50302282
47sequestering of actin monomers (GO:0042989)3.43764374
48protein localization to cilium (GO:0061512)3.43278681
49sexual reproduction (GO:0019953)3.34437820
50meiosis I (GO:0007127)3.33261936
51single strand break repair (GO:0000012)3.29248154
52intraciliary transport (GO:0042073)3.21870988
53GTP biosynthetic process (GO:0006183)3.19788048
54synapsis (GO:0007129)3.15499660
55nucleoside diphosphate phosphorylation (GO:0006165)3.15459619
56microtubule polymerization or depolymerization (GO:0031109)3.09107700
57mitotic sister chromatid cohesion (GO:0007064)3.06485090
58polyol catabolic process (GO:0046174)3.05931135
59cilium organization (GO:0044782)2.99862948
60meiotic cell cycle (GO:0051321)2.99775466
61lactate metabolic process (GO:0006089)2.98110175
62cellular component assembly involved in morphogenesis (GO:0010927)2.96303468
63regulation of spindle checkpoint (GO:0090231)2.95635716
64positive regulation of macrophage activation (GO:0043032)2.94673800
65amino-acid betaine transport (GO:0015838)2.93014049
66carnitine transport (GO:0015879)2.93014049
67microtubule-based movement (GO:0007018)2.89673656
68cilium assembly (GO:0042384)2.88438915
69centriole assembly (GO:0098534)2.87877989
70axoneme assembly (GO:0035082)2.87755721
71cilium morphogenesis (GO:0060271)2.87042758
72UTP biosynthetic process (GO:0006228)2.86740933
73carnitine transmembrane transport (GO:1902603)2.83386435
74alditol metabolic process (GO:0019400)2.81330812
75glycolytic process (GO:0006096)2.79744764
76nucleus organization (GO:0006997)2.72683775
77meiotic cell cycle process (GO:1903046)2.68600203
78gene silencing by RNA (GO:0031047)2.67027733
79centriole replication (GO:0007099)2.61732826
80regulation of centriole replication (GO:0046599)2.61312981
81protein refolding (GO:0042026)2.60944359
82UTP metabolic process (GO:0046051)2.60058746
83negative regulation of organelle assembly (GO:1902116)2.57744167
84single-organism membrane fusion (GO:0044801)2.46273003
85glycerol metabolic process (GO:0006071)2.46250457
86peptidyl-glutamic acid modification (GO:0018200)2.41462601
87nuclear pore complex assembly (GO:0051292)2.39542857
88cell wall macromolecule catabolic process (GO:0016998)15.1365085
89cell wall macromolecule metabolic process (GO:0044036)15.1365085
90fusion of sperm to egg plasma membrane (GO:0007342)14.9788933
91acrosome assembly (GO:0001675)13.7569674
92sperm motility (GO:0030317)12.7989843
93multicellular organism reproduction (GO:0032504)12.5355239
94sperm-egg recognition (GO:0035036)12.2849238
95plasma membrane fusion (GO:0045026)11.3993366
96cell-cell recognition (GO:0009988)11.0316849
97acrosome reaction (GO:0007340)10.8280078
98binding of sperm to zona pellucida (GO:0007339)10.7992108
99cilium or flagellum-dependent cell motility (GO:0001539)10.7435099
100reproduction (GO:0000003)10.4930470

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.49442319
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.27570555
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.87174864
4EZH2_22144423_ChIP-Seq_EOC_Human3.25579672
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.90616061
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.88408363
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.69363338
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.65608354
9PCGF2_27294783_Chip-Seq_ESCs_Mouse2.46298228
10KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse2.16748398
11CBX2_27304074_Chip-Seq_ESCs_Mouse2.13204081
12ZNF274_21170338_ChIP-Seq_K562_Hela2.13172037
13VDR_22108803_ChIP-Seq_LS180_Human2.11323433
14CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.06130117
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.02419623
16STAT6_21828071_ChIP-Seq_BEAS2B_Human2.01232810
17EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.97848360
18RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.95494287
19* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.89773154
20PCGF2_27294783_Chip-Seq_NPCs_Mouse1.89632902
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84226376
22KAP1_22055183_ChIP-Seq_ESCs_Mouse1.79568523
23ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.70927974
24KDM2B_26808549_Chip-Seq_REH_Human1.67888859
25* GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.66812637
26STAT1_17558387_ChIP-Seq_HELA_Human1.65564610
27NFE2_27457419_Chip-Seq_LIVER_Mouse1.63175345
28TAL1_26923725_Chip-Seq_HPCs_Mouse1.62444778
29GATA1_26923725_Chip-Seq_HPCs_Mouse1.60559071
30SUZ12_27294783_Chip-Seq_NPCs_Mouse1.60068474
31ELK4_26923725_Chip-Seq_MESODERM_Mouse1.58113661
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.57105231
33TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.54154418
34FLI1_21867929_ChIP-Seq_TH2_Mouse1.49272899
35GATA3_21867929_ChIP-Seq_CD8_Mouse1.49090889
36FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49075920
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46881769
38CBP_20019798_ChIP-Seq_JUKART_Human1.46881769
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45261162
40MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.44616878
41NANOG_18555785_Chip-Seq_ESCs_Mouse1.41144591
42CRX_20693478_ChIP-Seq_RETINA_Mouse1.39992779
43EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.37641520
44OCT4_18555785_Chip-Seq_ESCs_Mouse1.36369022
45SOX2_22085726_ChIP-Seq_NPCs_Mouse1.35471515
46GATA3_21867929_ChIP-Seq_TH1_Mouse1.32582223
47* LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.29769890
48P53_22387025_ChIP-Seq_ESCs_Mouse1.29744802
49CMYC_18555785_Chip-Seq_ESCs_Mouse1.29435604
50RNF2_27304074_Chip-Seq_NSC_Mouse1.28562076
51EZH2_27294783_Chip-Seq_NPCs_Mouse1.27477658
52P300_18555785_Chip-Seq_ESCs_Mouse1.26658714
53* WDR5_24793694_ChIP-Seq_LNCAP_Human1.25638936
54CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.25127898
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24661594
56KLF4_18555785_Chip-Seq_ESCs_Mouse1.22567895
57EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.22047120
58GF1_26923725_Chip-Seq_HPCs_Mouse1.21853085
59SUZ12_18555785_Chip-Seq_ESCs_Mouse1.21416703
60ESRRB_18555785_Chip-Seq_ESCs_Mouse1.20815924
61CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17981639
62TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17882632
63P53_21459846_ChIP-Seq_SAOS-2_Human1.17745316
64RUNX1_26923725_Chip-Seq_HPCs_Mouse1.16638931
65OCT4_21477851_ChIP-Seq_ESCs_Mouse1.15532799
66SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.14643583
67SOX2_18555785_Chip-Seq_ESCs_Mouse1.11780777
68STAT3_18555785_Chip-Seq_ESCs_Mouse1.11661618
69MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11256791
70REST_21632747_ChIP-Seq_MESCs_Mouse1.10053241
71EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09643357
72CTCF_18555785_Chip-Seq_ESCs_Mouse1.08907274
73SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.07185355
74* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.06706541
75TAF15_26573619_Chip-Seq_HEK293_Human1.06658239
76RUNX1_27457419_Chip-Seq_LIVER_Mouse1.04895798
77POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04720006
78TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04720006
79SPI1_26923725_Chip-Seq_HPCs_Mouse1.04403571
80E2F1_18555785_Chip-Seq_ESCs_Mouse1.03703568
81PU1_27457419_Chip-Seq_LIVER_Mouse1.03522740
82GF1B_26923725_Chip-Seq_HPCs_Mouse1.03058547
83FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03009158
84PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02484608
85SOX9_26525672_Chip-Seq_HEART_Mouse1.02172618
86PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01037147
87NMYC_18555785_Chip-Seq_ESCs_Mouse1.00504333
88SMAD1_18555785_Chip-Seq_ESCs_Mouse0.99782705
89ESET_19884257_ChIP-Seq_ESCs_Mouse0.99450429
90ZFX_18555785_Chip-Seq_ESCs_Mouse0.95707590
91LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.95173080
92EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.94705991
93RAD21_21589869_ChIP-Seq_MESCs_Mouse0.94108171
94KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.94042576
95ERG_20517297_ChIP-Seq_VCAP_Human0.92951911
96NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.92481216
97CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92336486
98RARA_24833708_ChIP-Seq_LIVER_Mouse0.90339248
99FLI1_21867929_ChIP-Seq_CD8_Mouse0.88003481
100CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.87915790

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.05581326
2MP0001929_abnormal_gametogenesis5.59070362
3MP0008877_abnormal_DNA_methylation4.49087177
4MP0002210_abnormal_sex_determination3.47093212
5MP0002161_abnormal_fertility/fecundity3.25461236
6MP0001145_abnormal_male_reproductive2.97185383
7MP0002653_abnormal_ependyma_morphology2.94065883
8MP0000653_abnormal_sex_gland2.59065962
9MP0005670_abnormal_white_adipose2.19335108
10MP0005623_abnormal_meninges_morphology2.11353166
11MP0005410_abnormal_fertilization16.0968300
12MP0002160_abnormal_reproductive_system1.55866330
13MP0008058_abnormal_DNA_repair1.49168694
14MP0002282_abnormal_trachea_morphology1.45149805
15MP0004233_abnormal_muscle_weight1.44981651
16MP0009046_muscle_twitch1.43186121
17MP0008057_abnormal_DNA_replication1.27287720
18MP0001984_abnormal_olfaction1.16185350
19MP0001765_abnormal_ion_homeostasis1.14310968
20MP0005647_abnormal_sex_gland1.04659418
21MP0003646_muscle_fatigue1.03928085
22MP0010094_abnormal_chromosome_stability0.90004527
23MP0005389_reproductive_system_phenotype0.80305022
24MP0002234_abnormal_pharynx_morphology0.70579655
25MP0002928_abnormal_bile_duct0.69690915
26MP0010307_abnormal_tumor_latency0.63220357
27MP0005636_abnormal_mineral_homeostasis0.61876928
28MP0008995_early_reproductive_senescence0.60377117
29MP0000569_abnormal_digit_pigmentation0.59495858
30MP0000358_abnormal_cell_content/0.51879861
31MP0003115_abnormal_respiratory_system0.51205930
32MP0003699_abnormal_female_reproductive0.50203699
33MP0005397_hematopoietic_system_phenotyp0.49591825
34MP0001545_abnormal_hematopoietic_system0.49591825
35MP0003183_abnormal_peptide_metabolism0.48896460
36MP0004036_abnormal_muscle_relaxation0.47959748
37MP0001324_abnormal_eye_pigmentation0.47099886
38MP0002132_abnormal_respiratory_system0.46671007
39MP0003011_delayed_dark_adaptation0.46062381
40MP0003950_abnormal_plasma_membrane0.45668801
41MP0002102_abnormal_ear_morphology0.44860807
42MP0002736_abnormal_nociception_after0.44415527
43MP0008007_abnormal_cellular_replicative0.42496621
44MP0003786_premature_aging0.42092373
45MP0004808_abnormal_hematopoietic_stem0.40727969
46MP0001119_abnormal_female_reproductive0.39919832
47MP0001293_anophthalmia0.39253902
48MP0002009_preneoplasia0.38819509
49MP0005551_abnormal_eye_electrophysiolog0.38304680
50MP0005253_abnormal_eye_physiology0.38029452
51MP0003633_abnormal_nervous_system0.36815030
52MP0002269_muscular_atrophy0.36649700
53MP0004019_abnormal_vitamin_homeostasis0.36356299
54MP0002405_respiratory_system_inflammati0.36261106
55MP0006036_abnormal_mitochondrial_physio0.33801553
56MP0009250_abnormal_appendicular_skeleto0.33240398
57MP0005666_abnormal_adipose_tissue0.33008748
58MP0004134_abnormal_chest_morphology0.31792733
59MP0005377_hearing/vestibular/ear_phenot0.31544734
60MP0003878_abnormal_ear_physiology0.31544734
61MP0001730_embryonic_growth_arrest0.31277732
62MP0002971_abnormal_brown_adipose0.28859021
63MP0003111_abnormal_nucleus_morphology0.28759475
64MP0009115_abnormal_fat_cell0.27859013
65MP0005391_vision/eye_phenotype0.27537738
66MP0004133_heterotaxia0.26319385
67MP0000313_abnormal_cell_death0.26077773
68MP0003329_amyloid_beta_deposits0.24609270
69MP0004811_abnormal_neuron_physiology0.24515840
70MP0001764_abnormal_homeostasis0.24364032
71MP0003631_nervous_system_phenotype0.22247366
72MP0003861_abnormal_nervous_system0.21489044
73MP0009697_abnormal_copulation0.20648306
74MP0002152_abnormal_brain_morphology0.19457308
75MP0001968_abnormal_touch/_nociception0.19408966
76MP0002169_no_abnormal_phenotype0.18641969
77MP0000427_abnormal_hair_cycle0.18533573
78MP0004084_abnormal_cardiac_muscle0.18506646
79MP0002873_normal_phenotype0.18434902
80MP0002837_dystrophic_cardiac_calcinosis0.18200075
81MP0003943_abnormal_hepatobiliary_system0.17774029
82MP0000432_abnormal_head_morphology0.17269216
83MP0002163_abnormal_gland_morphology0.15681662
84MP0000703_abnormal_thymus_morphology0.15383028
85MP0002084_abnormal_developmental_patter0.14754427
86MP0005319_abnormal_enzyme/_coenzyme0.14412920
87MP0002909_abnormal_adrenal_gland0.14369599
88MP0006072_abnormal_retinal_apoptosis0.13958996
89MP0003948_abnormal_gas_homeostasis0.13330259
90MP0005379_endocrine/exocrine_gland_phen0.13141770
91MP0000001_mammalian_phenotype0.12654384
92MP0003077_abnormal_cell_cycle0.12549178
93MP0003763_abnormal_thymus_physiology0.12281465
94MP0009278_abnormal_bone_marrow0.12039309
95MP0008961_abnormal_basal_metabolism0.11809833
96MP0001697_abnormal_embryo_size0.11642923
97MP0002139_abnormal_hepatobiliary_system0.11392730
98MP0002133_abnormal_respiratory_system0.11359818
99MP0005388_respiratory_system_phenotype0.11359818
100MP0002693_abnormal_pancreas_physiology0.11331871

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.85367412
2Abnormal respiratory motile cilium morphology (HP:0005938)9.04075545
3Abnormal respiratory epithelium morphology (HP:0012253)9.04075545
4Abnormal ciliary motility (HP:0012262)8.26140892
5Rhinitis (HP:0012384)8.02339080
6Chronic bronchitis (HP:0004469)7.58316393
7Nasal polyposis (HP:0100582)6.50688934
8Infertility (HP:0000789)6.12130271
9Abnormality of the nasal mucosa (HP:0000433)5.35190028
10Bronchitis (HP:0012387)4.80840357
11Bronchiectasis (HP:0002110)4.67108943
12Nephronophthisis (HP:0000090)4.07879448
13Recurrent sinusitis (HP:0011108)4.07140336
14Male infertility (HP:0003251)3.98498245
15Abnormal spermatogenesis (HP:0008669)3.49431994
16Recurrent otitis media (HP:0000403)3.44669952
17Medial flaring of the eyebrow (HP:0010747)3.06032443
18Abnormality of the renal medulla (HP:0100957)3.04391432
19Recurrent bronchitis (HP:0002837)2.95856334
20Abnormality of midbrain morphology (HP:0002418)2.84112088
21Molar tooth sign on MRI (HP:0002419)2.84112088
22Tubulointerstitial nephritis (HP:0001970)2.64069053
23Tubular atrophy (HP:0000092)2.56553519
24Azoospermia (HP:0000027)2.46271570
25Tubulointerstitial abnormality (HP:0001969)2.37529651
26Chronic sinusitis (HP:0011109)2.02255659
27Respiratory insufficiency due to defective ciliary clearance (HP:0200073)14.0160084
28Dynein arm defect of respiratory motile cilia (HP:0012255)13.0170252
29Absent/shortened dynein arms (HP:0200106)13.0170252
30Tubulointerstitial fibrosis (HP:0005576)1.98134808
31Congenital primary aphakia (HP:0007707)1.97615455
32Gait imbalance (HP:0002141)1.96483582
33Postaxial foot polydactyly (HP:0001830)1.95803956
34Congenital hepatic fibrosis (HP:0002612)1.95646045
35Tongue fasciculations (HP:0001308)1.95355354
36Pancreatic fibrosis (HP:0100732)1.92743718
37Impulsivity (HP:0100710)1.88335884
38Gonadotropin excess (HP:0000837)1.85812356
39Abnormality of the renal cortex (HP:0011035)1.77910642
40Muscle fibrillation (HP:0010546)1.77045602
41Fibular hypoplasia (HP:0003038)1.75727057
42Microglossia (HP:0000171)1.74833146
43Polydipsia (HP:0001959)1.72356755
44Abnormal drinking behavior (HP:0030082)1.72356755
45Nephrogenic diabetes insipidus (HP:0009806)1.71740573
46Aplasia/Hypoplasia of the tongue (HP:0010295)1.68876498
47Stage 5 chronic kidney disease (HP:0003774)1.68862694
48Absent frontal sinuses (HP:0002688)1.64840539
49Dyschromatopsia (HP:0007641)1.64044293
50Facial cleft (HP:0002006)1.63719615
51Postaxial hand polydactyly (HP:0001162)1.62852682
52J-shaped sella turcica (HP:0002680)1.61117251
53Hypoplasia of the capital femoral epiphysis (HP:0003090)1.60844077
54Decreased central vision (HP:0007663)1.59932669
55Abnormality of saccadic eye movements (HP:0000570)1.58775819
56Aplasia/Hypoplasia of the lens (HP:0008063)1.57822428
57Abnormality of renal excretion (HP:0011036)1.57777300
58Cystic liver disease (HP:0006706)1.56925678
59Short ribs (HP:0000773)1.55575299
60Abnormality of permanent molar morphology (HP:0011071)1.55179819
61Abnormality of the dental root (HP:0006486)1.55179819
62Taurodontia (HP:0000679)1.55179819
63Oculomotor apraxia (HP:0000657)1.52577962
64Genital tract atresia (HP:0001827)1.52359340
65Poor coordination (HP:0002370)1.51929978
66True hermaphroditism (HP:0010459)1.51264565
67Bile duct proliferation (HP:0001408)1.47978515
68Abnormal biliary tract physiology (HP:0012439)1.47978515
69Cholecystitis (HP:0001082)1.47472047
70Abnormal gallbladder physiology (HP:0012438)1.47472047
71Vaginal atresia (HP:0000148)1.45195026
72Renal dysplasia (HP:0000110)1.44983984
73Abnormality of molar morphology (HP:0011070)1.44784359
74Abnormality of molar (HP:0011077)1.44784359
75Bell-shaped thorax (HP:0001591)1.43714874
76Abnormality of ocular smooth pursuit (HP:0000617)1.43254354
77Asymmetric septal hypertrophy (HP:0001670)1.42874472
78Abnormality of the dental pulp (HP:0006479)1.40923642
79Abnormality of dentin (HP:0010299)1.40631251
80Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.38954353
81Median cleft lip (HP:0000161)1.37561383
82Deformed sella turcica (HP:0002681)1.36826023
83Optic nerve hypoplasia (HP:0000609)1.36621308
84Pancreatic cysts (HP:0001737)1.36363535
85Abnormality of the lower motor neuron (HP:0002366)1.32610628
86Cerebellar dysplasia (HP:0007033)1.29770980
87Heterotopia (HP:0002282)1.29617713
88Impaired smooth pursuit (HP:0007772)1.28733013
89Chronic hepatic failure (HP:0100626)1.28598889
90Vascular calcification (HP:0004934)1.28000701
91Short thorax (HP:0010306)1.26140455
92Absent epiphyses (HP:0010577)1.23273537
93Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.23273537
94Spastic tetraparesis (HP:0001285)1.22615960
95Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.21206004
96Amyotrophic lateral sclerosis (HP:0007354)1.18835189
97Abnormal urine output (HP:0012590)1.16998311
98Occipital encephalocele (HP:0002085)1.16636366
99Cardiovascular calcification (HP:0011915)1.16400173
100Congenital malformation of the right heart (HP:0011723)1.15740258

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK39.18488274
2PDK49.18488274
3PDK26.00619170
4TESK14.76668701
5PRKD33.68008772
6ICK2.98826051
7PTK2B2.50057032
8WNK42.20254380
9STK392.04779769
10PNCK1.50085198
11NEK21.46604959
12STK381.36811338
13PDK11.23344769
14DYRK1B1.17742302
15LMTK20.87057613
16DYRK30.81705745
17TYRO30.81454685
18PASK0.77241830
19IRAK10.73368052
20WNK10.73125190
21CHEK20.68777710
22MAPK150.68181964
23BRSK20.68106135
24RIPK40.64029650
25PDPK10.62681315
26CCNB10.61752510
27TESK20.59973031
28STK30.59476970
29WEE10.58182730
30MAP2K70.57959334
31EEF2K0.57524903
32TTK0.54549525
33PLK40.54435634
34MAP2K60.51988333
35STK38L0.51487625
36MAP3K100.47226919
37CHEK10.45130025
38STK100.43050443
39CDK120.41883902
40MAP3K40.39521902
41ATR0.36850778
42PAK10.35315272
43BRSK10.34394763
44ZAP700.32821971
45ATM0.31830065
46MARK30.31598144
47CAMK1G0.30569741
48CDC70.29542345
49NEK60.28866203
50PRKCG0.28565299
51PRKCQ0.26954692
52IRAK20.24200631
53PINK10.23833197
54RPS6KB10.23235211
55CAMKK10.22783456
56PAK20.20945977
57NTRK20.20868863
58PLK10.17698117
59CSF1R0.16233044
60MTOR0.15448036
61PRKG20.15196477
62PDGFRB0.14978428
63MAP4K10.13215568
64MUSK0.11084829
65PRKAA10.10476779
66CSNK2A10.09934898
67MAPKAPK50.09173664
68CDK150.08511887
69CSNK2A20.07899141
70PIM10.07392375
71BRAF0.07307915
72PRKCZ0.07145809
73PRKACG0.06712738
74CDK180.06705983
75PRKG10.06541278
76PKN10.06186903
77CDK10.05599509
78CDK11A0.05563618
79CDK20.05198579
80EGFR0.04940017
81RPS6KA10.04760168
82MAPK80.04720020
83CSNK1D0.04371676
84GSK3B0.04349779
85YES10.03788946
86MARK20.03310999
87CDK60.02997519
88TTN0.02962232
89PRKDC0.02344802
90SYK0.01794906
91CDK140.01488661
92PRKCD0.01125132
93PRKCB0.00541847
94TYK2-0.0193988
95TRIB3-0.0162685
96INSR-0.0141905
97PRKCA-0.0136646
98FRK-0.0134268
99AURKA-0.0118994
100MAPK10-0.0038698

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.55492594
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.31930160
3Pyruvate metabolism_Homo sapiens_hsa006203.88524901
4Fatty acid biosynthesis_Homo sapiens_hsa000613.65392785
5Propanoate metabolism_Homo sapiens_hsa006403.33780962
6Pentose phosphate pathway_Homo sapiens_hsa000303.21015811
7Basal transcription factors_Homo sapiens_hsa030222.91401777
8Glucagon signaling pathway_Homo sapiens_hsa049222.88134478
9Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.66000951
10Glycosaminoglycan degradation_Homo sapiens_hsa005312.52040009
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.29331157
12Linoleic acid metabolism_Homo sapiens_hsa005912.23576362
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.97740036
14Fanconi anemia pathway_Homo sapiens_hsa034601.92984723
15Selenocompound metabolism_Homo sapiens_hsa004501.92692242
16Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.89021797
17Oocyte meiosis_Homo sapiens_hsa041141.88830766
18Carbohydrate digestion and absorption_Homo sapiens_hsa049731.79383797
19Glycerolipid metabolism_Homo sapiens_hsa005611.79312757
20Amphetamine addiction_Homo sapiens_hsa050311.59893207
21Carbon metabolism_Homo sapiens_hsa012001.59530695
22PPAR signaling pathway_Homo sapiens_hsa033201.58832134
23Huntingtons disease_Homo sapiens_hsa050161.40564295
24Renin-angiotensin system_Homo sapiens_hsa046141.39447226
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.37313124
26Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.31144972
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.31028436
28Fructose and mannose metabolism_Homo sapiens_hsa000511.30789676
29Cardiac muscle contraction_Homo sapiens_hsa042601.26902817
30Renin secretion_Homo sapiens_hsa049241.26537134
31Mineral absorption_Homo sapiens_hsa049781.23818873
32Glycerophospholipid metabolism_Homo sapiens_hsa005641.20771996
33Biosynthesis of amino acids_Homo sapiens_hsa012301.19837219
34Purine metabolism_Homo sapiens_hsa002301.19717551
35Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.07297221
36Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.04036039
37Antigen processing and presentation_Homo sapiens_hsa046121.01882830
38RNA transport_Homo sapiens_hsa030131.00004891
39Fat digestion and absorption_Homo sapiens_hsa049750.98394431
40Dorso-ventral axis formation_Homo sapiens_hsa043200.97782384
41mRNA surveillance pathway_Homo sapiens_hsa030150.94011662
42Ether lipid metabolism_Homo sapiens_hsa005650.91444669
43Collecting duct acid secretion_Homo sapiens_hsa049660.88522941
44Long-term potentiation_Homo sapiens_hsa047200.88032255
45Fatty acid degradation_Homo sapiens_hsa000710.80806593
46Fatty acid metabolism_Homo sapiens_hsa012120.78380957
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.74049946
48Glutathione metabolism_Homo sapiens_hsa004800.73268367
49Insulin secretion_Homo sapiens_hsa049110.71876474
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.70958496
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69836817
52cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69563421
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69532899
54Thyroid hormone synthesis_Homo sapiens_hsa049180.68005199
55Systemic lupus erythematosus_Homo sapiens_hsa053220.67126604
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62959960
57Calcium signaling pathway_Homo sapiens_hsa040200.60610267
58Estrogen signaling pathway_Homo sapiens_hsa049150.60534090
59B cell receptor signaling pathway_Homo sapiens_hsa046620.58145757
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55498222
61Adipocytokine signaling pathway_Homo sapiens_hsa049200.55339754
62Central carbon metabolism in cancer_Homo sapiens_hsa052300.54054406
63Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.53562447
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51211460
65Inositol phosphate metabolism_Homo sapiens_hsa005620.50818578
66Homologous recombination_Homo sapiens_hsa034400.49502292
67Chemical carcinogenesis_Homo sapiens_hsa052040.48785097
68VEGF signaling pathway_Homo sapiens_hsa043700.45618081
69Arachidonic acid metabolism_Homo sapiens_hsa005900.44400919
70Sulfur metabolism_Homo sapiens_hsa009200.43195397
71Metabolic pathways_Homo sapiens_hsa011000.40483058
72Endocytosis_Homo sapiens_hsa041440.40228577
73Pancreatic secretion_Homo sapiens_hsa049720.40020539
74Legionellosis_Homo sapiens_hsa051340.39583082
75AMPK signaling pathway_Homo sapiens_hsa041520.38881862
76Taste transduction_Homo sapiens_hsa047420.38477281
77N-Glycan biosynthesis_Homo sapiens_hsa005100.38385354
78ABC transporters_Homo sapiens_hsa020100.38172509
79Synaptic vesicle cycle_Homo sapiens_hsa047210.37586482
80Bile secretion_Homo sapiens_hsa049760.37179889
81Protein digestion and absorption_Homo sapiens_hsa049740.34391981
82Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.34300674
83Hedgehog signaling pathway_Homo sapiens_hsa043400.33074495
84Gastric acid secretion_Homo sapiens_hsa049710.31911680
85Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.31850480
86Olfactory transduction_Homo sapiens_hsa047400.30927310
87Salivary secretion_Homo sapiens_hsa049700.29836808
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29717666
89T cell receptor signaling pathway_Homo sapiens_hsa046600.28208229
90Cell cycle_Homo sapiens_hsa041100.27747592
91Viral carcinogenesis_Homo sapiens_hsa052030.26204676
92Pyrimidine metabolism_Homo sapiens_hsa002400.25846868
93RNA degradation_Homo sapiens_hsa030180.24640067
94cAMP signaling pathway_Homo sapiens_hsa040240.24388217
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.24260000
96Lysine degradation_Homo sapiens_hsa003100.22699738
97Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.22173455
98Salmonella infection_Homo sapiens_hsa051320.21586262
99Alcoholism_Homo sapiens_hsa050340.19491582
100Circadian entrainment_Homo sapiens_hsa047130.18442920

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