EFCAB7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cornea development in camera-type eye (GO:0061303)7.57833506
2regulation of timing of cell differentiation (GO:0048505)6.56992534
3regulation of development, heterochronic (GO:0040034)6.20021654
4nuclear pore complex assembly (GO:0051292)5.78116813
5axonemal dynein complex assembly (GO:0070286)5.56542927
6cilium or flagellum-dependent cell motility (GO:0001539)5.00897197
7nuclear pore organization (GO:0006999)4.95577531
8hindbrain development (GO:0030902)4.79963626
9cilium movement (GO:0003341)4.67843968
10epithelial cilium movement (GO:0003351)4.52655649
11dorsal/ventral axis specification (GO:0009950)4.48019535
12pore complex assembly (GO:0046931)4.18897492
13metaphase plate congression (GO:0051310)4.06854693
14astrocyte differentiation (GO:0048708)4.00898302
15DNA replication-independent nucleosome organization (GO:0034724)4.00376529
16DNA replication-independent nucleosome assembly (GO:0006336)4.00376529
17CENP-A containing nucleosome assembly (GO:0034080)3.99971298
18mitotic metaphase plate congression (GO:0007080)3.99437167
19limb bud formation (GO:0060174)3.98480675
20presynaptic membrane assembly (GO:0097105)3.96013240
21pyrimidine nucleobase catabolic process (GO:0006208)3.93291898
22positive regulation of cell fate commitment (GO:0010455)3.90263741
23viral mRNA export from host cell nucleus (GO:0046784)3.88353358
24regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.83136513
25chromatin remodeling at centromere (GO:0031055)3.80849390
26cellular protein complex localization (GO:0034629)3.78844829
27positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.68789449
28positive regulation of mitotic sister chromatid separation (GO:1901970)3.68789449
29positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.68789449
30spermatid nucleus differentiation (GO:0007289)3.67105055
31DNA replication initiation (GO:0006270)3.65590112
32DNA ligation (GO:0006266)3.65569673
33mitotic sister chromatid cohesion (GO:0007064)3.65475018
34regulation of centriole replication (GO:0046599)3.65061125
35DNA replication-dependent nucleosome organization (GO:0034723)3.61524124
36DNA replication-dependent nucleosome assembly (GO:0006335)3.61524124
37positive regulation of neuroblast proliferation (GO:0002052)3.61447403
38regulation of sister chromatid cohesion (GO:0007063)3.60234068
39kinetochore organization (GO:0051383)3.59722653
40establishment of chromosome localization (GO:0051303)3.55648439
41telomere maintenance via recombination (GO:0000722)3.55364178
42DNA double-strand break processing (GO:0000729)3.55163382
43ribosomal small subunit assembly (GO:0000028)3.54930797
44telomere maintenance via semi-conservative replication (GO:0032201)3.54741317
45histone exchange (GO:0043486)3.54716319
46interkinetic nuclear migration (GO:0022027)3.50743176
47DNA unwinding involved in DNA replication (GO:0006268)3.50732943
48DNA strand elongation involved in DNA replication (GO:0006271)3.50136591
49cilium morphogenesis (GO:0060271)3.46756552
50protein complex localization (GO:0031503)3.44243643
51presynaptic membrane organization (GO:0097090)3.43490325
52mitotic recombination (GO:0006312)3.41646532
53microtubule depolymerization (GO:0007019)3.31058262
54retinal ganglion cell axon guidance (GO:0031290)3.30769708
55histone H2A acetylation (GO:0043968)3.30714387
56centriole replication (GO:0007099)3.28969517
57neural tube formation (GO:0001841)3.28723953
58pituitary gland development (GO:0021983)3.27818554
59DNA strand elongation (GO:0022616)3.27633719
60regulation of hexokinase activity (GO:1903299)3.26616547
61regulation of glucokinase activity (GO:0033131)3.26616547
62keratinocyte development (GO:0003334)3.26043836
63glial cell proliferation (GO:0014009)3.25094447
64binding of sperm to zona pellucida (GO:0007339)3.19256225
65cerebral cortex radially oriented cell migration (GO:0021799)3.17278676
66sperm-egg recognition (GO:0035036)3.15930472
67protein localization to chromosome, centromeric region (GO:0071459)3.14930208
68sequestering of actin monomers (GO:0042989)3.13664262
69positive regulation of mitochondrial fission (GO:0090141)3.11109982
70epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.10396917
71synapsis (GO:0007129)3.10358502
72nucleobase catabolic process (GO:0046113)3.08598064
73replication fork processing (GO:0031297)3.08174883
74cardiac ventricle formation (GO:0003211)3.07203910
75regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.06706885
76attachment of spindle microtubules to kinetochore (GO:0008608)3.06027901
77positive regulation of chromosome segregation (GO:0051984)3.05657289
78microtubule anchoring (GO:0034453)3.05101282
79limb development (GO:0060173)3.03187776
80appendage development (GO:0048736)3.03187776
81establishment of integrated proviral latency (GO:0075713)3.00520785
82negative regulation of epidermal cell differentiation (GO:0045605)3.00459497
83artery development (GO:0060840)2.99578387
84nonmotile primary cilium assembly (GO:0035058)2.98673320
85central nervous system projection neuron axonogenesis (GO:0021952)2.97842448
86chromatin assembly or disassembly (GO:0006333)2.97492983
87photoreceptor cell development (GO:0042461)2.97474574
88protein localization to kinetochore (GO:0034501)2.96704994
89somite development (GO:0061053)2.94078282
90glycosphingolipid biosynthetic process (GO:0006688)2.94001072
91glomerulus development (GO:0032835)2.93919412
92embryonic camera-type eye morphogenesis (GO:0048596)2.91715285
93nucleotide-excision repair, DNA gap filling (GO:0006297)2.91364584
94microtubule polymerization or depolymerization (GO:0031109)2.90634234
95gastrulation with mouth forming second (GO:0001702)2.88761848
96neuron fate commitment (GO:0048663)2.88436484
97smoothened signaling pathway (GO:0007224)2.87608098
98sister chromatid segregation (GO:0000819)2.86561856
99kinetochore assembly (GO:0051382)2.86561126
100cilium assembly (GO:0042384)2.86193868
101olfactory bulb development (GO:0021772)2.86158559
102cilium organization (GO:0044782)2.85182782
103positive regulation of histone H3-K4 methylation (GO:0051571)2.83892907
104nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.83682260
105centriole assembly (GO:0098534)2.82935379
106regulation of transcription involved in cell fate commitment (GO:0060850)2.82847527
107intraciliary transport (GO:0042073)2.82529900
108multicellular organism reproduction (GO:0032504)2.82364855
109cotranslational protein targeting to membrane (GO:0006613)2.81601310
110cardiac chamber formation (GO:0003207)2.80719421
111antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.80623976
112eye photoreceptor cell development (GO:0042462)2.78993255
113protein polyglutamylation (GO:0018095)2.78436889
114SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.77271566
115central nervous system neuron axonogenesis (GO:0021955)2.76187360
116cell-cell recognition (GO:0009988)2.75781492
117heart field specification (GO:0003128)2.75668681
118secondary heart field specification (GO:0003139)2.75668681
119termination of RNA polymerase II transcription (GO:0006369)2.75570507
120regulation of chromosome segregation (GO:0051983)2.75247776
121regulation of centrosome cycle (GO:0046605)2.74527810
122axonal fasciculation (GO:0007413)2.73404251
123neuron recognition (GO:0008038)2.72172136
124protein targeting to ER (GO:0045047)2.71638186
125neuron cell-cell adhesion (GO:0007158)2.71324891
126proteasome assembly (GO:0043248)2.70146622
127postsynaptic membrane organization (GO:0001941)2.69455802
128cell differentiation involved in metanephros development (GO:0072202)2.68720833
129viral transcription (GO:0019083)2.68335284
130histone H3-K9 methylation (GO:0051567)2.66966876
131regulation of cilium movement (GO:0003352)2.66934821
132DNA topological change (GO:0006265)2.65448553
133regulation of sarcomere organization (GO:0060297)2.65248336
134regulation of mitotic metaphase/anaphase transition (GO:0030071)2.64142818
135IMP biosynthetic process (GO:0006188)2.63744807
136regulation of telomere maintenance (GO:0032204)2.63457676
137nucleosome assembly (GO:0006334)2.63325716
138forebrain neuron differentiation (GO:0021879)2.62805075
139male meiosis (GO:0007140)2.62395948
140negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.62370610
141regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.62019759
142regulation of sister chromatid segregation (GO:0033045)2.61574192
143regulation of mitotic sister chromatid separation (GO:0010965)2.61574192
144regulation of mitotic sister chromatid segregation (GO:0033047)2.61574192
145embryonic foregut morphogenesis (GO:0048617)2.61057169
146ATP-dependent chromatin remodeling (GO:0043044)2.59798303
147DNA replication checkpoint (GO:0000076)2.58863310
148protein localization to microtubule (GO:0035372)2.58156362
149protein-DNA complex assembly (GO:0065004)2.57797848
150left/right axis specification (GO:0070986)2.57405879
151translational termination (GO:0006415)2.57164063
152spindle checkpoint (GO:0031577)2.55823456
153axoneme assembly (GO:0035082)2.55638273
154regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.55606452
155GTP biosynthetic process (GO:0006183)2.55353134
156termination of RNA polymerase I transcription (GO:0006363)2.54973765
157establishment of protein localization to endoplasmic reticulum (GO:0072599)2.54973749
158regulation of histone H3-K9 methylation (GO:0051570)2.54973001
159ribosomal small subunit biogenesis (GO:0042274)2.54351202
160negative regulation of epidermis development (GO:0045683)2.54073477
161lens development in camera-type eye (GO:0002088)2.54010476
162mitotic sister chromatid segregation (GO:0000070)2.53778284
163glandular epithelial cell development (GO:0002068)2.53180798
164positive regulation of dendritic spine morphogenesis (GO:0061003)2.52384436
165establishment of nucleus localization (GO:0040023)2.51245300
166negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.49365623
167negative regulation of translation, ncRNA-mediated (GO:0040033)2.49365623
168regulation of translation, ncRNA-mediated (GO:0045974)2.49365623
169negative regulation of axon guidance (GO:1902668)2.48947924
170hippocampus development (GO:0021766)2.48099659
171negative regulation of dendrite development (GO:2000171)2.47182934
172negative regulation of DNA recombination (GO:0045910)2.46201734
173regulation of cell fate specification (GO:0042659)2.45053424
174resolution of meiotic recombination intermediates (GO:0000712)2.44692010
175cerebral cortex cell migration (GO:0021795)2.44405761
176spinal cord development (GO:0021510)2.43091244
177specification of organ identity (GO:0010092)2.41985754
178pancreas development (GO:0031016)2.39937155
179regulation of gene expression by genetic imprinting (GO:0006349)2.38395543
180vocalization behavior (GO:0071625)2.35766678
181cellular component assembly involved in morphogenesis (GO:0010927)2.33826593
182ionotropic glutamate receptor signaling pathway (GO:0035235)2.33476573
183positive regulation of neural precursor cell proliferation (GO:2000179)2.33260744
184protein localization to cilium (GO:0061512)2.31451381
185maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.31231521

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.38625708
2RBPJ_22232070_ChIP-Seq_NCS_Mouse5.99096249
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.47712376
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.33358674
5FOXM1_23109430_ChIP-Seq_U2OS_Human4.17872675
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.96351354
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.34219044
8GBX2_23144817_ChIP-Seq_PC3_Human3.26545757
9ELK1_19687146_ChIP-ChIP_HELA_Human3.11718210
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.91779310
11AR_21909140_ChIP-Seq_LNCAP_Human2.84859310
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.83833147
13IGF1R_20145208_ChIP-Seq_DFB_Human2.79515803
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.77807476
15TAF15_26573619_Chip-Seq_HEK293_Human2.65350653
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.59249968
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.58624179
18TP63_19390658_ChIP-ChIP_HaCaT_Human2.57391681
19EZH2_22144423_ChIP-Seq_EOC_Human2.50815359
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.44619597
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.38935186
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.33311813
23MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.31208260
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.30138515
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.26605034
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.18483071
27P300_19829295_ChIP-Seq_ESCs_Human2.13421436
28* VDR_23849224_ChIP-Seq_CD4+_Human2.10329030
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.09390753
30HOXB4_20404135_ChIP-ChIP_EML_Mouse2.02302301
31NELFA_20434984_ChIP-Seq_ESCs_Mouse2.00575648
32* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.98680750
33MYC_19079543_ChIP-ChIP_MESCs_Mouse1.95909901
34MYC_19030024_ChIP-ChIP_MESCs_Mouse1.93861731
35EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.93374141
36CREB1_15753290_ChIP-ChIP_HEK293T_Human1.90873305
37KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.90135338
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.86798807
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.86388872
40SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.83365421
41MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.83354045
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.82465352
43* SMAD4_21799915_ChIP-Seq_A2780_Human1.82058757
44SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.81667462
45NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.81631377
46XRN2_22483619_ChIP-Seq_HELA_Human1.81138374
47* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.77631448
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.73203639
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.71886300
50* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71772353
51CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.68501167
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.65717243
53HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.62316821
54RNF2_27304074_Chip-Seq_NSC_Mouse1.61863147
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.61736996
56ELF1_17652178_ChIP-ChIP_JURKAT_Human1.60134374
57MYC_18358816_ChIP-ChIP_MESCs_Mouse1.58391955
58STAT3_23295773_ChIP-Seq_U87_Human1.57577151
59E2F1_21310950_ChIP-Seq_MCF-7_Human1.55581783
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.55311097
61ETS1_20019798_ChIP-Seq_JURKAT_Human1.55021024
62EWS_26573619_Chip-Seq_HEK293_Human1.54834375
63MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.54163704
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.53456656
65IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.52136706
66CBP_20019798_ChIP-Seq_JUKART_Human1.52136706
67* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.51487540
68* FOXP3_21729870_ChIP-Seq_TREG_Human1.51474452
69SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.51124180
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49280740
71TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48185518
72POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.48185518
73ERG_20887958_ChIP-Seq_HPC-7_Mouse1.48063917
74IRF1_19129219_ChIP-ChIP_H3396_Human1.45679279
75FUS_26573619_Chip-Seq_HEK293_Human1.44981165
76E2F1_18555785_ChIP-Seq_MESCs_Mouse1.43750116
77NR3C1_21868756_ChIP-Seq_MCF10A_Human1.41460957
78YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40659219
79PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39036102
80PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.37523804
81ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37315133
82* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.36783159
83TTF2_22483619_ChIP-Seq_HELA_Human1.36066120
84TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35305154
85SOX2_18555785_ChIP-Seq_MESCs_Mouse1.34819781
86AR_25329375_ChIP-Seq_VCAP_Human1.34468014
87MYCN_18555785_ChIP-Seq_MESCs_Mouse1.34248533
88POU5F1_16153702_ChIP-ChIP_HESCs_Human1.34147240
89ER_23166858_ChIP-Seq_MCF-7_Human1.33185383
90RUNX2_22187159_ChIP-Seq_PCA_Human1.32361341
91NANOG_18555785_Chip-Seq_ESCs_Mouse1.31904430
92EZH2_27304074_Chip-Seq_ESCs_Mouse1.30784259
93ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29911919
94* TCF4_23295773_ChIP-Seq_U87_Human1.27423203
95GABP_19822575_ChIP-Seq_HepG2_Human1.25642344
96TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.24020731
97TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.23819575
98EZH2_27294783_Chip-Seq_NPCs_Mouse1.23784353
99AHR_22903824_ChIP-Seq_MCF-7_Human1.23347282
100EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23190962
101E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.22404745
102POU3F2_20337985_ChIP-ChIP_501MEL_Human1.22040320
103RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22025843
104ARNT_22903824_ChIP-Seq_MCF-7_Human1.20395417
105BCAT_22108803_ChIP-Seq_LS180_Human1.19966238
106MYC_18940864_ChIP-ChIP_HL60_Human1.19794618
107TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19372426
108SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19058009
109BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18929093
110SRF_21415370_ChIP-Seq_HL-1_Mouse1.18859720
111DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.18012681
112ZNF274_21170338_ChIP-Seq_K562_Hela1.17232109
113NANOG_21062744_ChIP-ChIP_HESCs_Human1.16925232
114TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16847895
115SOX9_26525672_Chip-Seq_HEART_Mouse1.15770090
116P53_22387025_ChIP-Seq_ESCs_Mouse1.12162692
117PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.11915256
118PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11904683
119KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11138835
120CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.10797651
121PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10364634
122* REST_21632747_ChIP-Seq_MESCs_Mouse1.10211444
123TP53_18474530_ChIP-ChIP_U2OS_Human1.09982187
124SOX2_21211035_ChIP-Seq_LN229_Gbm1.09424739
125TP53_22573176_ChIP-Seq_HFKS_Human1.09056860
126NFE2_27457419_Chip-Seq_LIVER_Mouse1.08759925
127TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08538112
128EED_16625203_ChIP-ChIP_MESCs_Mouse1.06910463
129SMAD4_21741376_ChIP-Seq_EPCs_Human1.06869356
130TCF4_22108803_ChIP-Seq_LS180_Human1.06480383
131CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.06454452
132LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06124945
133GATA1_26923725_Chip-Seq_HPCs_Mouse1.06123054
134JUN_21703547_ChIP-Seq_K562_Human1.04188732
135FLI1_21867929_ChIP-Seq_TH2_Mouse1.03862779
136WT1_19549856_ChIP-ChIP_CCG9911_Human1.03641552
137TBX3_20139965_ChIP-Seq_ESCs_Mouse1.03551526
138TBX3_20139965_ChIP-Seq_MESCs_Mouse1.03344520
139SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.03150376
140ELK1_22589737_ChIP-Seq_MCF10A_Human1.02978114
141JARID2_20064375_ChIP-Seq_MESCs_Mouse1.02330357
142E2F1_18555785_Chip-Seq_ESCs_Mouse1.02124769
143EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98952161
144SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.95298579
145YY1_21170310_ChIP-Seq_MESCs_Mouse0.94140798
146RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94087599
147STAT6_21828071_ChIP-Seq_BEAS2B_Human0.91881370
148HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.91451294
149NANOG_16153702_ChIP-ChIP_HESCs_Human0.91191136
150CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.91142840
151CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91020918
152* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90881953
153CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90066890
154* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.89104648
155SOX2_16153702_ChIP-ChIP_HESCs_Human0.87856917
156KDM5A_27292631_Chip-Seq_BREAST_Human0.87538740
157DCP1A_22483619_ChIP-Seq_HELA_Human0.87411487
158CIITA_25753668_ChIP-Seq_RAJI_Human0.87255861
159BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.87177976
160EGR1_19374776_ChIP-ChIP_THP-1_Human0.86057030
161SALL1_21062744_ChIP-ChIP_HESCs_Human0.84178628
162TAL1_26923725_Chip-Seq_HPCs_Mouse0.83459371
163CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.83291525
164ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.80213903
165FLI1_27457419_Chip-Seq_LIVER_Mouse0.79354214
166VDR_22108803_ChIP-Seq_LS180_Human0.77838190
167LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.77449803
168PKCTHETA_26484144_Chip-Seq_BREAST_Human0.76234016
169CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.75251394
170POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.71276569
171POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.69709794
172HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.69659073
173GATA1_22025678_ChIP-Seq_K562_Human0.68843302
174SOX17_20123909_ChIP-Seq_XEN_Mouse0.68743430
175SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.68073885

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology5.59574488
2MP0005257_abnormal_intraocular_pressure3.75569319
3MP0002638_abnormal_pupillary_reflex3.60752329
4MP0005248_abnormal_Harderian_gland3.09280730
5MP0004957_abnormal_blastocyst_morpholog2.86034107
6MP0010094_abnormal_chromosome_stability2.77673775
7MP0008877_abnormal_DNA_methylation2.54576888
8MP0002938_white_spotting2.52169885
9MP0005187_abnormal_penis_morphology2.47351155
10MP0003136_yellow_coat_color2.35335624
11MP0008057_abnormal_DNA_replication2.32839315
12MP0000566_synostosis2.31519382
13MP0002653_abnormal_ependyma_morphology2.30651392
14MP0003693_abnormal_embryo_hatching2.30594890
15MP0003787_abnormal_imprinting2.29133134
16MP0000778_abnormal_nervous_system2.26177848
17MP0008058_abnormal_DNA_repair2.23163402
18MP0003880_abnormal_central_pattern2.16030360
19MP0003077_abnormal_cell_cycle2.14626086
20MP0002009_preneoplasia2.13491007
21MP0006292_abnormal_olfactory_placode2.11890103
22MP0002282_abnormal_trachea_morphology2.06826404
23MP0008932_abnormal_embryonic_tissue2.04854421
24MP0010352_gastrointestinal_tract_polyps2.03934777
25MP0008007_abnormal_cellular_replicative2.02473108
26MP0003121_genomic_imprinting2.01853687
27MP0000372_irregular_coat_pigmentation1.89233218
28MP0002396_abnormal_hematopoietic_system1.87573770
29MP0008789_abnormal_olfactory_epithelium1.83544250
30MP0005410_abnormal_fertilization1.81700777
31MP0004270_analgesia1.78762647
32MP0000465_gastrointestinal_hemorrhage1.75975298
33MP0003111_abnormal_nucleus_morphology1.69441964
34MP0002928_abnormal_bile_duct1.66963138
35MP0002234_abnormal_pharynx_morphology1.61908546
36MP0004133_heterotaxia1.59040416
37MP0009046_muscle_twitch1.56897442
38MP0001919_abnormal_reproductive_system1.56223277
39MP0002210_abnormal_sex_determination1.55956121
40MP0002249_abnormal_larynx_morphology1.55887474
41MP0003937_abnormal_limbs/digits/tail_de1.53824181
42MP0000647_abnormal_sebaceous_gland1.53587591
43MP0002822_catalepsy1.52517650
44MP0003122_maternal_imprinting1.51619897
45MP0002095_abnormal_skin_pigmentation1.45377905
46MP0001929_abnormal_gametogenesis1.40939613
47MP0008995_early_reproductive_senescence1.38297228
48MP0005253_abnormal_eye_physiology1.35401988
49MP0004885_abnormal_endolymph1.33961418
50MP0002735_abnormal_chemical_nociception1.33658105
51MP0004808_abnormal_hematopoietic_stem1.32072994
52MP0001486_abnormal_startle_reflex1.30911088
53MP0002837_dystrophic_cardiac_calcinosis1.30773166
54MP0001905_abnormal_dopamine_level1.30759156
55MP0005551_abnormal_eye_electrophysiolog1.30464028
56MP0002163_abnormal_gland_morphology1.29948983
57MP0002132_abnormal_respiratory_system1.26808699
58MP0002233_abnormal_nose_morphology1.24726789
59MP0001984_abnormal_olfaction1.23680777
60MP0000653_abnormal_sex_gland1.22149936
61MP0003698_abnormal_male_reproductive1.22053167
62MP0001145_abnormal_male_reproductive1.22051037
63MP0002751_abnormal_autonomic_nervous1.21114523
64MP0004859_abnormal_synaptic_plasticity1.18593755
65MP0003942_abnormal_urinary_system1.16826443
66MP0001293_anophthalmia1.15552827
67MP0006276_abnormal_autonomic_nervous1.14724789
68MP0002177_abnormal_outer_ear1.14605822
69MP0003943_abnormal_hepatobiliary_system1.14571457
70MP0002736_abnormal_nociception_after1.14312466
71MP0005367_renal/urinary_system_phenotyp1.12026009
72MP0000516_abnormal_urinary_system1.12026009
73MP0003635_abnormal_synaptic_transmissio1.11758039
74MP0000383_abnormal_hair_follicle1.11370743
75MP0002092_abnormal_eye_morphology1.10547219
76MP0003890_abnormal_embryonic-extraembry1.10214898
77MP0000631_abnormal_neuroendocrine_gland1.09693781
78MP0000955_abnormal_spinal_cord1.08591349
79MP0002272_abnormal_nervous_system1.08273502
80MP0005389_reproductive_system_phenotype1.08229643
81MP0000428_abnormal_craniofacial_morphol1.05904265
82MP0005084_abnormal_gallbladder_morpholo1.05326939
83MP0002184_abnormal_innervation1.05288257
84MP0001968_abnormal_touch/_nociception1.04985077
85MP0002932_abnormal_joint_morphology1.04791205
86MP0002084_abnormal_developmental_patter1.04075983
87MP0000490_abnormal_crypts_of1.03930687
88MP0005394_taste/olfaction_phenotype1.03608026
89MP0005499_abnormal_olfactory_system1.03608026
90MP0002734_abnormal_mechanical_nocicepti1.01652482
91MP0003941_abnormal_skin_development1.00973413
92MP0010678_abnormal_skin_adnexa1.00849652
93MP0001851_eye_inflammation1.00566459
94MP0009745_abnormal_behavioral_response1.00549656
95MP0010386_abnormal_urinary_bladder0.99353779
96MP0001346_abnormal_lacrimal_gland0.99217796
97MP0005623_abnormal_meninges_morphology0.97852508
98MP0005391_vision/eye_phenotype0.97005796
99MP0009250_abnormal_appendicular_skeleto0.96687521
100MP0005508_abnormal_skeleton_morphology0.96593826
101MP0002063_abnormal_learning/memory/cond0.96011099
102MP0000049_abnormal_middle_ear0.94642284
103MP0002557_abnormal_social/conspecific_i0.94512169
104MP0000569_abnormal_digit_pigmentation0.93479437
105MP0005379_endocrine/exocrine_gland_phen0.92197090
106MP0003861_abnormal_nervous_system0.91672906
107MP0002697_abnormal_eye_size0.91326544
108MP0000537_abnormal_urethra_morphology0.91238009
109MP0000613_abnormal_salivary_gland0.90757182
110MP0003786_premature_aging0.90372970
111MP0001324_abnormal_eye_pigmentation0.89650814
112MP0003011_delayed_dark_adaptation0.89470764
113MP0002572_abnormal_emotion/affect_behav0.89151057
114MP0003935_abnormal_craniofacial_develop0.89039676
115MP0003315_abnormal_perineum_morphology0.88724130
116MP0004197_abnormal_fetal_growth/weight/0.88306622
117MP0002752_abnormal_somatic_nervous0.87588989
118MP0000350_abnormal_cell_proliferation0.87506917
119MP0000462_abnormal_digestive_system0.86202865
120MP0002882_abnormal_neuron_morphology0.85838151
121MP0002102_abnormal_ear_morphology0.85276433
122MP0001188_hyperpigmentation0.84666138
123MP0001672_abnormal_embryogenesis/_devel0.84382832
124MP0005380_embryogenesis_phenotype0.84382832
125MP0001697_abnormal_embryo_size0.84227421
126MP0001119_abnormal_female_reproductive0.84181609
127MP0003938_abnormal_ear_development0.83569294
128MP0005195_abnormal_posterior_eye0.83352223
129MP0005423_abnormal_somatic_nervous0.82263994
130MP0002098_abnormal_vibrissa_morphology0.81450000
131MP0002064_seizures0.80963091
132MP0000427_abnormal_hair_cycle0.80956489
133MP0002877_abnormal_melanocyte_morpholog0.80718940
134MP0003755_abnormal_palate_morphology0.79037065
135MP0004142_abnormal_muscle_tone0.79009429
136MP0002127_abnormal_cardiovascular_syste0.78591105
137MP0002085_abnormal_embryonic_tissue0.77998134
138MP0004811_abnormal_neuron_physiology0.77803486
139MP0009672_abnormal_birth_weight0.77241891
140MP0002152_abnormal_brain_morphology0.77204338
141MP0001485_abnormal_pinna_reflex0.77107783
142MP0003385_abnormal_body_wall0.77090618
143MP0002067_abnormal_sensory_capabilities0.76749672
144MP0003567_abnormal_fetal_cardiomyocyte0.76410714
145MP0000534_abnormal_ureter_morphology0.76211453
146MP0005646_abnormal_pituitary_gland0.75689421
147MP0002160_abnormal_reproductive_system0.75577352
148MP0004215_abnormal_myocardial_fiber0.75522463
149MP0005386_behavior/neurological_phenoty0.75113369
150MP0004924_abnormal_behavior0.75113369
151MP0001286_abnormal_eye_development0.74943853
152MP0005409_darkened_coat_color0.73304658
153MP0004381_abnormal_hair_follicle0.73013570
154MP0003119_abnormal_digestive_system0.72561123
155MP0005645_abnormal_hypothalamus_physiol0.72203349
156MP0009703_decreased_birth_body0.71818029
157MP0006072_abnormal_retinal_apoptosis0.71695080
158MP0003984_embryonic_growth_retardation0.71395020
159MP0009697_abnormal_copulation0.68689705

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.75521115
2Abnormal respiratory motile cilium physiology (HP:0012261)5.40904996
3Hypoplasia of the fovea (HP:0007750)4.83221022
4Aplasia/Hypoplasia of the fovea (HP:0008060)4.83221022
5Rhinitis (HP:0012384)4.71656363
6Abnormality of the fovea (HP:0000493)4.17624376
7Volvulus (HP:0002580)4.15257705
8Abnormal ciliary motility (HP:0012262)4.12254596
9Colon cancer (HP:0003003)3.90944892
10Stomach cancer (HP:0012126)3.87734825
11Abnormal respiratory epithelium morphology (HP:0012253)3.85448310
12Abnormal respiratory motile cilium morphology (HP:0005938)3.85448310
13Chronic bronchitis (HP:0004469)3.75945909
14Curly hair (HP:0002212)3.57658163
15Dynein arm defect of respiratory motile cilia (HP:0012255)3.56858505
16Absent/shortened dynein arms (HP:0200106)3.56858505
17Papillary thyroid carcinoma (HP:0002895)3.54607669
18Optic nerve hypoplasia (HP:0000609)3.36388878
19True hermaphroditism (HP:0010459)3.31801657
20Intestinal atresia (HP:0011100)3.23415767
21High anterior hairline (HP:0009890)3.11771612
22Medial flaring of the eyebrow (HP:0010747)3.06861627
23Tubulointerstitial nephritis (HP:0001970)3.05430715
24Pancreatic fibrosis (HP:0100732)3.05371868
25Gait imbalance (HP:0002141)2.97258624
26Abnormality of midbrain morphology (HP:0002418)2.96557234
27Molar tooth sign on MRI (HP:0002419)2.96557234
28Supernumerary spleens (HP:0009799)2.93519545
29Pancreatic cysts (HP:0001737)2.92836094
30Neoplasm of the adrenal cortex (HP:0100641)2.92003591
31Medulloblastoma (HP:0002885)2.88332852
32Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.86980264
33Aplasia/Hypoplasia of the sacrum (HP:0008517)2.86366967
34Aplasia/Hypoplasia of the macula (HP:0008059)2.83966654
35Bell-shaped thorax (HP:0001591)2.81812176
36Fibular hypoplasia (HP:0003038)2.80912107
37Depressed nasal tip (HP:0000437)2.79752961
38Congenital primary aphakia (HP:0007707)2.75454947
39Abnormal lung lobation (HP:0002101)2.75375213
40Aplasia/Hypoplasia of the lens (HP:0008063)2.72335338
41Nephrogenic diabetes insipidus (HP:0009806)2.68188897
42Bronchiectasis (HP:0002110)2.67412535
43Thyroid carcinoma (HP:0002890)2.64773800
44Hyperventilation (HP:0002883)2.62531051
45Genital tract atresia (HP:0001827)2.60300002
46Aplasia/Hypoplasia affecting the retina (HP:0008061)2.60091122
47Anophthalmia (HP:0000528)2.56840432
48Nephronophthisis (HP:0000090)2.56197985
49Wide intermamillary distance (HP:0006610)2.52870994
50Abnormal pancreas size (HP:0012094)2.52660688
51Hepatoblastoma (HP:0002884)2.46917407
52Absent eyebrow (HP:0002223)2.45607612
53Aplasia/Hypoplasia of the tongue (HP:0010295)2.44735948
54Overriding aorta (HP:0002623)2.44228289
55Vaginal atresia (HP:0000148)2.43286531
56Hip dysplasia (HP:0001385)2.41262715
57Cystic hygroma (HP:0000476)2.38528361
58Absent frontal sinuses (HP:0002688)2.38108917
59Abnormality of the renal medulla (HP:0100957)2.36210625
60Back pain (HP:0003418)2.35785003
61Drooling (HP:0002307)2.34724447
62Occipital encephalocele (HP:0002085)2.33520986
6311 pairs of ribs (HP:0000878)2.31013161
64Postaxial foot polydactyly (HP:0001830)2.29707959
65Abnormal number of erythroid precursors (HP:0012131)2.29106202
66Prolonged bleeding time (HP:0003010)2.28481509
67Abnormality of the heme biosynthetic pathway (HP:0010472)2.28210538
68Median cleft lip (HP:0000161)2.25842138
69Abnormality of cells of the erythroid lineage (HP:0012130)2.24759343
70Spinal cord lesions (HP:0100561)2.23156988
71Syringomyelia (HP:0003396)2.23156988
72Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.21732868
73Difficulty running (HP:0009046)2.19922899
74Renal duplication (HP:0000075)2.18968712
75Oligodactyly (hands) (HP:0001180)2.18097569
76Limb dystonia (HP:0002451)2.17193530
77Preaxial hand polydactyly (HP:0001177)2.15133594
78Selective tooth agenesis (HP:0001592)2.14804369
79Abnormality of the labia minora (HP:0012880)2.13959708
80Renal hypoplasia (HP:0000089)2.13449085
81Postaxial hand polydactyly (HP:0001162)2.12517922
82Adrenal hypoplasia (HP:0000835)2.12305510
83Single umbilical artery (HP:0001195)2.09767570
84Abnormality of the fetal cardiovascular system (HP:0010948)2.09767570
85Abnormal umbilical cord blood vessels (HP:0011403)2.09767570
86Excessive salivation (HP:0003781)2.09049355
87Methylmalonic acidemia (HP:0002912)2.06810439
88Absent speech (HP:0001344)2.06397511
89Flat cornea (HP:0007720)2.04814512
90Increased nuchal translucency (HP:0010880)2.04212500
91Subacute progressive viral hepatitis (HP:0006572)2.03882732
92Chronic hepatic failure (HP:0100626)2.01063381
93Neoplasm of the adrenal gland (HP:0100631)2.00231897
94Gastrointestinal atresia (HP:0002589)1.99448576
95Supernumerary bones of the axial skeleton (HP:0009144)1.97372577
96Poor coordination (HP:0002370)1.96499234
97Narrow forehead (HP:0000341)1.94621961
98Hyperglycinemia (HP:0002154)1.94165089
99Pulmonary artery stenosis (HP:0004415)1.94026291
100Broad-based gait (HP:0002136)1.93548004
101Congenital hepatic fibrosis (HP:0002612)1.93257101
102Stenosis of the external auditory canal (HP:0000402)1.91748981
103Broad foot (HP:0001769)1.91675557
104Micropenis (HP:0000054)1.90820005
105Anencephaly (HP:0002323)1.90332815
106Asymmetry of the thorax (HP:0001555)1.89255010
107Supernumerary ribs (HP:0005815)1.88456319
108Biliary tract neoplasm (HP:0100574)1.88043920
109Abnormality of the dental root (HP:0006486)1.87902340
110Taurodontia (HP:0000679)1.87902340
111Abnormality of permanent molar morphology (HP:0011071)1.87902340
112Facial cleft (HP:0002006)1.87598778
113Ependymoma (HP:0002888)1.87130987
114Abnormal hair whorl (HP:0010721)1.86965006
115Abnormality of chromosome stability (HP:0003220)1.85818479
116Radioulnar synostosis (HP:0002974)1.85262621
117Missing ribs (HP:0000921)1.84741221
118Hemivertebrae (HP:0002937)1.84682203
119Lissencephaly (HP:0001339)1.84160759
120Sclerocornea (HP:0000647)1.83613296
121Vesicoureteral reflux (HP:0000076)1.83068884
122Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.83006586
123Cystic liver disease (HP:0006706)1.82971303
124Abnormality of the frontal sinuses (HP:0002687)1.82610210
125Aplasia/Hypoplasia of the uvula (HP:0010293)1.81433121
126Hypochromic microcytic anemia (HP:0004840)1.81425403
127Neoplasm of the oral cavity (HP:0100649)1.81290294
128Fair hair (HP:0002286)1.80684979
129Aplasia/Hypoplasia of the fibula (HP:0006492)1.80540587
130Astrocytoma (HP:0009592)1.80446870
131Abnormality of the astrocytes (HP:0100707)1.80446870
132Febrile seizures (HP:0002373)1.80176861
133Abnormality of molar morphology (HP:0011070)1.79758904
134Abnormality of molar (HP:0011077)1.79758904
135Abnormality of dentin (HP:0010299)1.79757607
136Gonadotropin excess (HP:0000837)1.79073294
137Astigmatism (HP:0000483)1.78451596
138Oligodactyly (HP:0012165)1.78420855
139Decreased testicular size (HP:0008734)1.77623548
140Bronchitis (HP:0012387)1.77296311
141Renal dysplasia (HP:0000110)1.76927627
142Specific learning disability (HP:0001328)1.76718634
143Inability to walk (HP:0002540)1.75939311
144Birth length less than 3rd percentile (HP:0003561)1.74532339
145Renal cortical cysts (HP:0000803)1.74454337
146Cortical dysplasia (HP:0002539)1.74042178
147Hypochromic anemia (HP:0001931)1.73991106
148Deep philtrum (HP:0002002)1.73709421
149Shawl scrotum (HP:0000049)1.73636793
150Optic nerve coloboma (HP:0000588)1.73607065
151Long nose (HP:0003189)1.73079183
152Chronic sinusitis (HP:0011109)1.72794717
153Blue irides (HP:0000635)1.72353155
154Hip contracture (HP:0003273)1.71468707
155Abnormality of the renal cortex (HP:0011035)1.70906044
156Tented upper lip vermilion (HP:0010804)1.70027854
157Abnormal hemoglobin (HP:0011902)1.69744425
158Focal motor seizures (HP:0011153)1.69716274
159Progressive inability to walk (HP:0002505)1.69386689
160Meckel diverticulum (HP:0002245)1.69261018
161Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.69212656
162Degeneration of the lateral corticospinal tracts (HP:0002314)1.69212656
163Abnormality of the diencephalon (HP:0010662)1.68704542
164Aganglionic megacolon (HP:0002251)1.68182180
165Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.67734875
166Short 4th metacarpal (HP:0010044)1.67734875
167Progressive cerebellar ataxia (HP:0002073)1.67136591
168Glioma (HP:0009733)1.66617803
169Abnormality of the dental pulp (HP:0006479)1.66555168
170Aplasia/Hypoplasia of the sternum (HP:0006714)1.66208862
171Myelomeningocele (HP:0002475)1.65811355
172Hypoplastic labia majora (HP:0000059)1.65431549
173Action tremor (HP:0002345)1.64702078
174Hyperacusis (HP:0010780)1.64588462
175Prominent nasal bridge (HP:0000426)1.63907301
176Abnormality of the ileum (HP:0001549)1.63001334
177Scrotal hypoplasia (HP:0000046)1.62966257
178Chronic otitis media (HP:0000389)1.62868988
179Elfin facies (HP:0004428)1.62502920

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK14.08498959
2VRK13.90136293
3MARK13.73145609
4ICK3.67359486
5MAP3K43.05422732
6CASK2.99379536
7CDC72.77226751
8WEE12.64679921
9BMPR1B2.45638991
10MAP2K72.43163142
11MAP4K22.37144935
12MAPKAPK52.36465500
13CCNB12.26855520
14SRPK12.24980140
15CSNK1G32.22597863
16NEK12.13703080
17NEK22.09114563
18CSNK1A1L2.05295114
19MUSK2.05178812
20PLK42.03368844
21PTK2B2.03175671
22BCR1.99359563
23ACVR1B1.95492349
24TRIM281.94428635
25PLK31.91685991
26ERBB31.88648028
27STK38L1.86881731
28CDK71.80250116
29BUB11.65638664
30MST41.65344020
31CSNK1G11.64142329
32PASK1.63620683
33FRK1.61229019
34ZAK1.61093113
35DYRK31.57191767
36EIF2AK31.56046076
37RPS6KB21.55343511
38MAPK151.51272735
39EPHA41.49590204
40CSNK1G21.47165409
41AURKB1.39508545
42TTK1.39264466
43PLK21.39001217
44ATR1.32508007
45MAP3K121.23524435
46PINK11.20373308
47EPHA31.17880373
48IRAK21.16262375
49GRK11.15570169
50NTRK21.14449118
51TGFBR11.11255307
52PAK31.09686166
53PLK11.09516132
54PKN11.08938896
55TNIK1.07195425
56RPS6KA51.04494723
57AURKA1.03313583
58PBK1.01972307
59CHEK21.01839553
60STK101.00020319
61TESK10.99311697
62CDK30.98917713
63GRK60.98572488
64UHMK10.97820988
65STK160.97519746
66LATS10.96836335
67EPHB20.95115048
68TNK20.94497713
69PNCK0.94453338
70HIPK20.94160547
71MYLK0.92988685
72INSRR0.92765500
73SGK20.92487835
74CDK80.90822639
75MAP2K40.90719037
76MAPK130.88218345
77LRRK20.87687809
78PRKCG0.84485110
79MKNK20.83691851
80ATM0.82450993
81STK390.81764050
82CDK190.79742306
83TEC0.79036284
84CDK60.76361532
85YES10.75813125
86BTK0.75421870
87EIF2AK10.75115479
88WNK40.74562235
89OXSR10.74334413
90MINK10.74111992
91STK240.74111910
92DYRK1B0.73658124
93DYRK20.72363567
94CDK40.71123905
95SGK2230.67851404
96SGK4940.67851404
97IRAK40.66135303
98PTK60.65838985
99CHEK10.65449238
100PAK60.64847691
101BRSK20.64483796
102PRKCE0.63369812
103AKT30.62990657
104PDK40.61255688
105PDK30.61255688
106CSNK2A10.61174188
107NUAK10.59497727
108BMPR20.58281921
109CDK50.58209537
110TAOK30.57321808
111PAK40.57301749
112BRD40.56967057
113FLT30.55075767
114KSR10.54531259
115PIM10.54177265
116NME10.54135050
117ADRBK20.54002320
118PHKG20.53566874
119PHKG10.53566874
120STK30.52567293
121TAOK20.52001659
122WNK30.51745905
123CDK20.48846316
124OBSCN0.48815912
125PRPF4B0.47349585
126CSNK2A20.47244911
127RPS6KA40.45811223
128CSNK1A10.45162123
129CAMK2A0.44084358
130CAMK2B0.42732701
131CLK10.42629556
132TSSK60.42536707
133MOS0.42233413
134NEK60.40547202
135MAP3K80.40378927
136PAK20.40058894
137MET0.39754943
138CSNK1D0.39688802
139DYRK1A0.39556695
140SGK30.38976330
141FGFR20.38309349
142FER0.37174097
143RPS6KB10.36454682
144CDK10.35738368
145WNK10.34701997
146TRPM70.34414079
147SIK20.32790132
148PRKACB0.31501853
149EIF2AK20.30987670
150NLK0.25904138
151PRKG20.25123671
152MAPKAPK20.24948194

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.57711794
2Spliceosome_Homo sapiens_hsa030403.33121311
3Nicotine addiction_Homo sapiens_hsa050333.19027735
4Protein export_Homo sapiens_hsa030603.17594311
5Mismatch repair_Homo sapiens_hsa034303.04854644
6Base excision repair_Homo sapiens_hsa034102.89166516
7Ribosome_Homo sapiens_hsa030102.85726117
8Basal transcription factors_Homo sapiens_hsa030222.76939243
9Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.59992829
10Steroid biosynthesis_Homo sapiens_hsa001002.52157029
11Cell cycle_Homo sapiens_hsa041102.45619105
12RNA transport_Homo sapiens_hsa030132.42292578
13Nucleotide excision repair_Homo sapiens_hsa034202.40651779
14RNA degradation_Homo sapiens_hsa030182.32484416
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.28152947
16Non-homologous end-joining_Homo sapiens_hsa034502.27665695
17RNA polymerase_Homo sapiens_hsa030202.20108883
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.19401468
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.17262945
20Homologous recombination_Homo sapiens_hsa034402.11520429
21Pyrimidine metabolism_Homo sapiens_hsa002401.92965937
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.87997866
23Alcoholism_Homo sapiens_hsa050341.78922585
24Fanconi anemia pathway_Homo sapiens_hsa034601.77489594
25Phototransduction_Homo sapiens_hsa047441.75676039
26Propanoate metabolism_Homo sapiens_hsa006401.72875172
27Systemic lupus erythematosus_Homo sapiens_hsa053221.64921882
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.54143487
29GABAergic synapse_Homo sapiens_hsa047271.51921018
30Dorso-ventral axis formation_Homo sapiens_hsa043201.51600769
31Basal cell carcinoma_Homo sapiens_hsa052171.49528896
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.45411831
33Taste transduction_Homo sapiens_hsa047421.43577922
34Dopaminergic synapse_Homo sapiens_hsa047281.40840186
35Butanoate metabolism_Homo sapiens_hsa006501.39527883
36Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.38226937
37mRNA surveillance pathway_Homo sapiens_hsa030151.34240225
38Glutamatergic synapse_Homo sapiens_hsa047241.33936567
39Proteasome_Homo sapiens_hsa030501.32689413
40Axon guidance_Homo sapiens_hsa043601.31546847
41p53 signaling pathway_Homo sapiens_hsa041151.30868822
42Morphine addiction_Homo sapiens_hsa050321.30427088
43Circadian entrainment_Homo sapiens_hsa047131.29678087
44Purine metabolism_Homo sapiens_hsa002301.29145127
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.25983007
46Vitamin B6 metabolism_Homo sapiens_hsa007501.23673544
47Endometrial cancer_Homo sapiens_hsa052131.20803661
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19576076
49Nitrogen metabolism_Homo sapiens_hsa009101.19477668
50Acute myeloid leukemia_Homo sapiens_hsa052211.13651816
51Viral carcinogenesis_Homo sapiens_hsa052031.10156379
52Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.07575295
53One carbon pool by folate_Homo sapiens_hsa006701.07227555
54Transcriptional misregulation in cancer_Homo sapiens_hsa052021.05769761
55Circadian rhythm_Homo sapiens_hsa047101.04941043
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.01368582
57Non-small cell lung cancer_Homo sapiens_hsa052231.01157045
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.00007583
59MicroRNAs in cancer_Homo sapiens_hsa052060.99848938
60Huntingtons disease_Homo sapiens_hsa050160.97688888
61Oocyte meiosis_Homo sapiens_hsa041140.94667097
62Thyroid cancer_Homo sapiens_hsa052160.91347754
63Antigen processing and presentation_Homo sapiens_hsa046120.88520654
64Collecting duct acid secretion_Homo sapiens_hsa049660.88073923
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87202348
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.86660445
67Epstein-Barr virus infection_Homo sapiens_hsa051690.85137275
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.84532183
69Insulin secretion_Homo sapiens_hsa049110.84350626
70Chronic myeloid leukemia_Homo sapiens_hsa052200.83672907
71Serotonergic synapse_Homo sapiens_hsa047260.82855165
72Regulation of autophagy_Homo sapiens_hsa041400.81430125
73Prostate cancer_Homo sapiens_hsa052150.80300704
74HTLV-I infection_Homo sapiens_hsa051660.79233567
75Peroxisome_Homo sapiens_hsa041460.76403399
76Glioma_Homo sapiens_hsa052140.75466933
77Cocaine addiction_Homo sapiens_hsa050300.75294413
78Olfactory transduction_Homo sapiens_hsa047400.74807117
79Pathways in cancer_Homo sapiens_hsa052000.74633188
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74611085
81Parkinsons disease_Homo sapiens_hsa050120.74085951
82Small cell lung cancer_Homo sapiens_hsa052220.73160346
83Herpes simplex infection_Homo sapiens_hsa051680.72757567
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.72181260
85Sulfur metabolism_Homo sapiens_hsa009200.68468558
86Synaptic vesicle cycle_Homo sapiens_hsa047210.67827369
87Hippo signaling pathway_Homo sapiens_hsa043900.66706655
88Prolactin signaling pathway_Homo sapiens_hsa049170.66148886
89Amphetamine addiction_Homo sapiens_hsa050310.62425170
90Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.61968426
91TGF-beta signaling pathway_Homo sapiens_hsa043500.61931656
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61400923
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61147516
94Hedgehog signaling pathway_Homo sapiens_hsa043400.59035782
95Alzheimers disease_Homo sapiens_hsa050100.58101227
96Ether lipid metabolism_Homo sapiens_hsa005650.57905947
97Caffeine metabolism_Homo sapiens_hsa002320.57856773
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56587620
99N-Glycan biosynthesis_Homo sapiens_hsa005100.56254974
100Long-term depression_Homo sapiens_hsa047300.55979655
101Estrogen signaling pathway_Homo sapiens_hsa049150.54569948
102Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54228973
103Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.53282481
104Wnt signaling pathway_Homo sapiens_hsa043100.52618248
105B cell receptor signaling pathway_Homo sapiens_hsa046620.51937568
106Salivary secretion_Homo sapiens_hsa049700.51652217
107Lysine degradation_Homo sapiens_hsa003100.51025074
108Colorectal cancer_Homo sapiens_hsa052100.50883647
109Cysteine and methionine metabolism_Homo sapiens_hsa002700.50403432
110Primary bile acid biosynthesis_Homo sapiens_hsa001200.50398558
111Cardiac muscle contraction_Homo sapiens_hsa042600.50298188
112Leukocyte transendothelial migration_Homo sapiens_hsa046700.50284116
113Arachidonic acid metabolism_Homo sapiens_hsa005900.50167405
114T cell receptor signaling pathway_Homo sapiens_hsa046600.49198945
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49089918
116Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47696504
117SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47542681
118cAMP signaling pathway_Homo sapiens_hsa040240.46934552
119Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44559443
120ErbB signaling pathway_Homo sapiens_hsa040120.44103159
121Oxidative phosphorylation_Homo sapiens_hsa001900.43945149
122Maturity onset diabetes of the young_Homo sapiens_hsa049500.43602365
123Selenocompound metabolism_Homo sapiens_hsa004500.42811238
124Metabolic pathways_Homo sapiens_hsa011000.42521546
125Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42519182
126Calcium signaling pathway_Homo sapiens_hsa040200.40974889
127Glutathione metabolism_Homo sapiens_hsa004800.40708374
128Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.38460396
129beta-Alanine metabolism_Homo sapiens_hsa004100.37839573
130Ovarian steroidogenesis_Homo sapiens_hsa049130.37178246
131Platelet activation_Homo sapiens_hsa046110.36882966
132Pyruvate metabolism_Homo sapiens_hsa006200.36858053
133Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.36124877
134Retinol metabolism_Homo sapiens_hsa008300.35114523
135Proteoglycans in cancer_Homo sapiens_hsa052050.34535028
136alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34275325
137Cholinergic synapse_Homo sapiens_hsa047250.33547372
138Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.32902496
139Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32685109
140Linoleic acid metabolism_Homo sapiens_hsa005910.32022782
141Renal cell carcinoma_Homo sapiens_hsa052110.31541243
142Folate biosynthesis_Homo sapiens_hsa007900.30187775
143Hepatitis B_Homo sapiens_hsa051610.29156155
144Gap junction_Homo sapiens_hsa045400.28959541
145Shigellosis_Homo sapiens_hsa051310.28731535
146Notch signaling pathway_Homo sapiens_hsa043300.28603117
147Adherens junction_Homo sapiens_hsa045200.26475808
148GnRH signaling pathway_Homo sapiens_hsa049120.26191627
149PI3K-Akt signaling pathway_Homo sapiens_hsa041510.25692287
150Galactose metabolism_Homo sapiens_hsa000520.24618233
151Neurotrophin signaling pathway_Homo sapiens_hsa047220.24602119
152Drug metabolism - other enzymes_Homo sapiens_hsa009830.24417371
153Renin-angiotensin system_Homo sapiens_hsa046140.23884181
154Pentose and glucuronate interconversions_Homo sapiens_hsa000400.22251942
155Melanoma_Homo sapiens_hsa052180.21691548
156Hematopoietic cell lineage_Homo sapiens_hsa046400.21597235
157Jak-STAT signaling pathway_Homo sapiens_hsa046300.20865312

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