EFCAB5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)9.71634334
2plasma membrane fusion (GO:0045026)9.67626498
3binding of sperm to zona pellucida (GO:0007339)9.63686889
4male meiosis (GO:0007140)9.44803837
5cell-cell recognition (GO:0009988)9.37676859
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.30646020
7cilium movement (GO:0003341)9.18281877
8motile cilium assembly (GO:0044458)9.06510110
9spermatid development (GO:0007286)8.71022390
10reproduction (GO:0000003)8.59141730
11synaptonemal complex organization (GO:0070193)8.48606568
12synaptonemal complex assembly (GO:0007130)8.09751239
13regulation of cilium movement (GO:0003352)7.98030071
14cell wall macromolecule catabolic process (GO:0016998)7.79573615
15cell wall macromolecule metabolic process (GO:0044036)7.79573615
16single fertilization (GO:0007338)7.23300003
17DNA methylation involved in gamete generation (GO:0043046)7.01360493
18sperm capacitation (GO:0048240)6.75087730
19male meiosis I (GO:0007141)6.43878013
20fertilization (GO:0009566)6.30208894
21ventricular system development (GO:0021591)5.74340912
22chromosome organization involved in meiosis (GO:0070192)5.68810133
23negative regulation of inclusion body assembly (GO:0090084)5.68257265
24spermatogenesis (GO:0007283)5.54444628
25male gamete generation (GO:0048232)5.52901596
26meiotic nuclear division (GO:0007126)5.44492550
27meiosis I (GO:0007127)5.24036595
28germ cell development (GO:0007281)5.13938078
29cellular process involved in reproduction in multicellular organism (GO:0022412)5.12509567
30gamete generation (GO:0007276)5.08475034
31meiotic cell cycle (GO:0051321)5.03276034
32protein localization to cilium (GO:0061512)4.89909555
33microtubule depolymerization (GO:0007019)4.89041831
34seminiferous tubule development (GO:0072520)4.88985423
35regulation of microtubule-based movement (GO:0060632)4.70879380
36microtubule severing (GO:0051013)4.68468715
37cell recognition (GO:0008037)4.59871382
38monoubiquitinated protein deubiquitination (GO:0035520)4.58528489
39regulation of inclusion body assembly (GO:0090083)4.55121223
40calcium ion-dependent exocytosis (GO:0017156)4.54749866
41response to pheromone (GO:0019236)4.50367380
42organic cation transport (GO:0015695)4.48587246
43left/right pattern formation (GO:0060972)4.48072831
44gene silencing by RNA (GO:0031047)4.46932984
45behavioral response to nicotine (GO:0035095)4.42396588
46intraciliary transport (GO:0042073)4.24457655
47neural tube formation (GO:0001841)4.14752981
48genitalia morphogenesis (GO:0035112)4.10721913
49detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.06784957
50protein polyglutamylation (GO:0018095)4.06478902
51multicellular organismal reproductive process (GO:0048609)3.98655813
52negative regulation of organelle assembly (GO:1902116)3.93789849
53axoneme assembly (GO:0035082)3.92210421
54detection of light stimulus involved in visual perception (GO:0050908)3.85431583
55detection of light stimulus involved in sensory perception (GO:0050962)3.85431583
56indolalkylamine metabolic process (GO:0006586)3.79173060
57microtubule-based movement (GO:0007018)3.79086567
58fucose catabolic process (GO:0019317)3.78575698
59L-fucose metabolic process (GO:0042354)3.78575698
60L-fucose catabolic process (GO:0042355)3.78575698
61regulation of centriole replication (GO:0046599)3.65477564
62regulation of meiosis I (GO:0060631)3.62861758
63cellular ketone body metabolic process (GO:0046950)3.55018256
64cornea development in camera-type eye (GO:0061303)3.52477386
65meiotic cell cycle process (GO:1903046)3.51141179
66tryptophan catabolic process (GO:0006569)3.50596074
67indole-containing compound catabolic process (GO:0042436)3.50596074
68indolalkylamine catabolic process (GO:0046218)3.50596074
69regulation of protein polyubiquitination (GO:1902914)3.50254326
70lactate metabolic process (GO:0006089)3.49401343
71platelet dense granule organization (GO:0060155)3.49293602
72gamma-aminobutyric acid transport (GO:0015812)3.42508690
73kynurenine metabolic process (GO:0070189)3.35938559
74spermatid nucleus differentiation (GO:0007289)3.31536958
75cilium organization (GO:0044782)3.31491656
76centriole replication (GO:0007099)3.30982043
77synapsis (GO:0007129)3.30113865
78ketone body metabolic process (GO:1902224)3.29944755
79multicellular organismal development (GO:0007275)3.27709967
80nuclear pore complex assembly (GO:0051292)3.25040587
81negative regulation of DNA repair (GO:0045738)3.22711126
82chaperone-mediated protein complex assembly (GO:0051131)3.22589186
83nonmotile primary cilium assembly (GO:0035058)3.20516475
84pyrimidine nucleobase catabolic process (GO:0006208)3.19031368
85behavioral response to ethanol (GO:0048149)3.18486653
86cilium assembly (GO:0042384)3.15206624
87DNA deamination (GO:0045006)3.12647300
88photoreceptor cell maintenance (GO:0045494)3.11725383
89carnitine transmembrane transport (GO:1902603)3.08246910
90polyol catabolic process (GO:0046174)3.07586503
91alditol metabolic process (GO:0019400)3.05750093
92carnitine transport (GO:0015879)3.05526106
93amino-acid betaine transport (GO:0015838)3.05526106
94centriole assembly (GO:0098534)3.04504770
95negative regulation of mast cell activation (GO:0033004)3.04499334
96negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.04345635
97negative regulation of translation, ncRNA-mediated (GO:0040033)3.04345635
98regulation of translation, ncRNA-mediated (GO:0045974)3.04345635
99cilium morphogenesis (GO:0060271)3.02979696
100cellular component assembly involved in morphogenesis (GO:0010927)2.99585777
101tryptophan metabolic process (GO:0006568)2.97681046
102mitotic sister chromatid cohesion (GO:0007064)2.97124005
103regulation of chromatin binding (GO:0035561)2.95765063
104gene silencing (GO:0016458)2.94997711
105photoreceptor cell development (GO:0042461)2.94531509
106dopamine transport (GO:0015872)2.93816279
107regulation of hippo signaling (GO:0035330)2.92811008
108negative regulation of cytosolic calcium ion concentration (GO:0051481)2.90649754
109inner ear receptor stereocilium organization (GO:0060122)2.90122786
110regulation of spindle checkpoint (GO:0090231)2.89649639
111nucleobase catabolic process (GO:0046113)2.87079261
112nucleoside diphosphate phosphorylation (GO:0006165)2.85887214
113regulation of action potential (GO:0098900)2.85875034
114head development (GO:0060322)2.85465503
115limb bud formation (GO:0060174)2.84138790
116protein K11-linked deubiquitination (GO:0035871)2.83557806
117transmission of nerve impulse (GO:0019226)2.82850153
118regulation of hexokinase activity (GO:1903299)2.82624012
119regulation of glucokinase activity (GO:0033131)2.82624012
120protein complex biogenesis (GO:0070271)2.80719856
121glycerol ether metabolic process (GO:0006662)2.80641649
122hindbrain development (GO:0030902)2.79965285
123water-soluble vitamin biosynthetic process (GO:0042364)2.79821114
124indole-containing compound metabolic process (GO:0042430)2.79816800
125retinal cone cell development (GO:0046549)2.78772051
126DNA double-strand break processing (GO:0000729)2.78512808
127DNA alkylation (GO:0006305)2.77157053
128DNA methylation (GO:0006306)2.77157053
129auditory receptor cell stereocilium organization (GO:0060088)2.75938270
130glycerol metabolic process (GO:0006071)2.75233109
131positive regulation of protein homodimerization activity (GO:0090073)2.73544116
132peptidyl-glutamic acid modification (GO:0018200)2.73518958
133regulation of rhodopsin mediated signaling pathway (GO:0022400)2.73134146
134protein refolding (GO:0042026)2.72784364
135G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.72235999
136neuronal action potential (GO:0019228)2.70820439
137mitochondrial respiratory chain complex I assembly (GO:0032981)2.68975398
138NADH dehydrogenase complex assembly (GO:0010257)2.68975398
139mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.68975398
140detection of mechanical stimulus involved in sensory perception (GO:0050974)2.68636977
141reciprocal DNA recombination (GO:0035825)2.66563157
142reciprocal meiotic recombination (GO:0007131)2.66563157
143reflex (GO:0060004)2.66090426
144eye photoreceptor cell development (GO:0042462)2.65804812
145sulfation (GO:0051923)2.65269466
146adaptation of signaling pathway (GO:0023058)2.64371486
147respiratory chain complex IV assembly (GO:0008535)2.63867918
148pore complex assembly (GO:0046931)2.62834249
149replication fork processing (GO:0031297)2.62448321
150rhodopsin mediated signaling pathway (GO:0016056)2.61766864
151nucleus organization (GO:0006997)2.61295847
152cAMP catabolic process (GO:0006198)2.60656875
153establishment of protein localization to Golgi (GO:0072600)2.60463171
154amine catabolic process (GO:0009310)2.59505369
155cellular biogenic amine catabolic process (GO:0042402)2.59505369
156ether metabolic process (GO:0018904)2.57768575
157left/right axis specification (GO:0070986)2.57493479
158negative regulation of transcription regulatory region DNA binding (GO:2000678)2.55579629
159mitochondrial respiratory chain complex assembly (GO:0033108)2.54670776
160DNA packaging (GO:0006323)2.54639116
161microtubule polymerization or depolymerization (GO:0031109)2.53832428
162chromosome condensation (GO:0030261)2.53009290
163tachykinin receptor signaling pathway (GO:0007217)2.52787252
164somite development (GO:0061053)2.52114196
165serotonin metabolic process (GO:0042428)2.50166395
166recombinational repair (GO:0000725)2.49933380
167positive regulation of oligodendrocyte differentiation (GO:0048714)2.48810952
168double-strand break repair via homologous recombination (GO:0000724)2.48790655
169regulation of collateral sprouting (GO:0048670)2.47896211
170embryonic epithelial tube formation (GO:0001838)2.47251634
171synaptic transmission, cholinergic (GO:0007271)2.46165833
172DNA integration (GO:0015074)2.45690444
173cyclic nucleotide catabolic process (GO:0009214)2.45064018
174cilium or flagellum-dependent cell motility (GO:0001539)17.6636969
175fusion of sperm to egg plasma membrane (GO:0007342)12.7047260
176sperm motility (GO:0030317)11.5489867
177piRNA metabolic process (GO:0034587)11.5068132
178axonemal dynein complex assembly (GO:0070286)11.1721153
179multicellular organism reproduction (GO:0032504)10.7013724
180sperm-egg recognition (GO:0035036)10.4635513
181acrosome assembly (GO:0001675)10.3265935
182epithelial cilium movement (GO:0003351)10.1529711

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.80841190
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.76909852
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.08072569
4GBX2_23144817_ChIP-Seq_PC3_Human3.20458898
5IGF1R_20145208_ChIP-Seq_DFB_Human2.77775260
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.76701210
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.64416596
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.47173904
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.42680220
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.40401840
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.39548499
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.35861761
13PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.32645317
14FUS_26573619_Chip-Seq_HEK293_Human2.23488576
15P300_19829295_ChIP-Seq_ESCs_Human2.16004705
16EWS_26573619_Chip-Seq_HEK293_Human2.14313742
17PCGF2_27294783_Chip-Seq_ESCs_Mouse2.12925613
18ZNF274_21170338_ChIP-Seq_K562_Hela2.06762209
19CTBP1_25329375_ChIP-Seq_LNCAP_Human2.04789992
20CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.02459727
21EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.00758865
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.0177798
23GATA1_26923725_Chip-Seq_HPCs_Mouse1.92851520
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.89186541
25UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.74864137
26STAT3_23295773_ChIP-Seq_U87_Human1.73144118
27PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72916230
28ELK4_26923725_Chip-Seq_MESODERM_Mouse1.72153782
29PIAS1_25552417_ChIP-Seq_VCAP_Human1.71411970
30VDR_22108803_ChIP-Seq_LS180_Human1.67191050
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.64223126
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.62510138
33NFE2_27457419_Chip-Seq_LIVER_Mouse1.56997129
34AR_25329375_ChIP-Seq_VCAP_Human1.55723665
35MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.55640266
36WDR5_24793694_ChIP-Seq_LNCAP_Human1.55151321
37* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.53514892
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.53192880
39NR3C1_21868756_ChIP-Seq_MCF10A_Human1.51858020
40SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48943464
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46866098
42STAT1_17558387_ChIP-Seq_HELA_Human1.45024840
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.44598028
44RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.43507833
45KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.42822309
46TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42761737
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.42207238
48OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41336085
49RBPJ_22232070_ChIP-Seq_NCS_Mouse1.38770334
50TAL1_26923725_Chip-Seq_HPCs_Mouse1.37964511
51KAP1_22055183_ChIP-Seq_ESCs_Mouse1.35593991
52* TP53_22573176_ChIP-Seq_HFKS_Human1.35412866
53REST_21632747_ChIP-Seq_MESCs_Mouse1.34586875
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.33672150
55KDM2B_26808549_Chip-Seq_REH_Human1.33446922
56ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.33322962
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.32522221
58TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31670373
59NANOG_19829295_ChIP-Seq_ESCs_Human1.31249935
60SOX2_19829295_ChIP-Seq_ESCs_Human1.31249935
61RUNX2_22187159_ChIP-Seq_PCA_Human1.31151747
62KLF5_20875108_ChIP-Seq_MESCs_Mouse1.31059060
63* GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.30853038
64* CBP_20019798_ChIP-Seq_JUKART_Human1.28593687
65* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28593687
66TCF4_22108803_ChIP-Seq_LS180_Human1.27843587
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26244290
68FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25255476
69IRF1_19129219_ChIP-ChIP_H3396_Human1.23525011
70PRDM14_20953172_ChIP-Seq_ESCs_Human1.23488761
71ZFP57_27257070_Chip-Seq_ESCs_Mouse1.23231351
72POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22867136
73TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22867136
74MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.21461407
75BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17834292
76GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15685181
77NANOG_18555785_Chip-Seq_ESCs_Mouse1.15137242
78* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14864514
79* FOXA1_25329375_ChIP-Seq_VCAP_Human1.14864514
80EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14313852
81* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13323346
82* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12876345
83STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12216766
84CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12117828
85CRX_20693478_ChIP-Seq_RETINA_Mouse1.11845816
86CDX2_22108803_ChIP-Seq_LS180_Human1.11811670
87* FLI1_21867929_ChIP-Seq_TH2_Mouse1.11770299
88OCT4_18555785_Chip-Seq_ESCs_Mouse1.11740847
89EZH2_27294783_Chip-Seq_NPCs_Mouse1.11184549
90TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11140381
91RNF2_27304074_Chip-Seq_NSC_Mouse1.10417877
92SOX2_22085726_ChIP-Seq_NPCs_Mouse1.10234494
93SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.09189330
94P53_22387025_ChIP-Seq_ESCs_Mouse1.08702273
95* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07542598
96TCF4_23295773_ChIP-Seq_U87_Human1.07415938
97GATA3_21867929_ChIP-Seq_CD8_Mouse1.06566905
98RUNX1_26923725_Chip-Seq_HPCs_Mouse1.06161088
99CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05758616
100P300_18555785_Chip-Seq_ESCs_Mouse1.04965766
101SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.04311909
102EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.03266682
103SOX2_21211035_ChIP-Seq_LN229_Gbm1.02528014
104GATA3_21867929_ChIP-Seq_TH1_Mouse1.02223124
105CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.02070775
106KLF4_18555785_Chip-Seq_ESCs_Mouse1.01988956
107MYC_18940864_ChIP-ChIP_HL60_Human1.01701365
108OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01650548
109GF1_26923725_Chip-Seq_HPCs_Mouse1.01529907
110CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00760466
111TAF15_26573619_Chip-Seq_HEK293_Human1.00152536
112NCOR_22424771_ChIP-Seq_293T_Human1.00121403
113AR_21572438_ChIP-Seq_LNCaP_Human0.99821042
114GATA3_21878914_ChIP-Seq_MCF-7_Human0.99715615
115STAT3_18555785_Chip-Seq_ESCs_Mouse0.99709636
116ETV2_25802403_ChIP-Seq_MESCs_Mouse0.99313675
117* LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.98986773
118JUN_21703547_ChIP-Seq_K562_Human0.97680016
119ARNT_22903824_ChIP-Seq_MCF-7_Human0.96489143
120ESRRB_18555785_Chip-Seq_ESCs_Mouse0.96106689
121CMYC_18555785_Chip-Seq_ESCs_Mouse0.95797572
122AR_20517297_ChIP-Seq_VCAP_Human0.95766423
123PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.95681963
124TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94229312
125SUZ12_18555785_Chip-Seq_ESCs_Mouse0.94109579
126BCAT_22108803_ChIP-Seq_LS180_Human0.93491889
127ER_23166858_ChIP-Seq_MCF-7_Human0.93142872
128MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.92759763
129SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.92378166
130RUNX1_27457419_Chip-Seq_LIVER_Mouse0.90159806
131PU1_27457419_Chip-Seq_LIVER_Mouse0.87800461
132* P53_21459846_ChIP-Seq_SAOS-2_Human0.86598007
133FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86461888
134E2F1_18555785_Chip-Seq_ESCs_Mouse0.86003087
135PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.85592656
136SOX9_26525672_Chip-Seq_HEART_Mouse0.84953722
137AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.84797472
138RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.84114291
139SOX2_21211035_ChIP-Seq_LN229_Human0.83961784
140PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.83909304
141CTCF_18555785_Chip-Seq_ESCs_Mouse0.83589974
142SMAD4_21799915_ChIP-Seq_A2780_Human0.83394704
143ZFX_18555785_Chip-Seq_ESCs_Mouse0.82441581
144* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.82327185
145* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.81926125
146NFYB_21822215_ChIP-Seq_K562_Human0.81826527
147PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81486090
148* SMAD4_21741376_ChIP-Seq_EPCs_Human0.81475370
149TBL1_22424771_ChIP-Seq_293T_Human0.81425671
150ERG_20517297_ChIP-Seq_VCAP_Human0.81050714

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.92598500
2MP0008877_abnormal_DNA_methylation5.60923511
3MP0001929_abnormal_gametogenesis5.44307201
4MP0002210_abnormal_sex_determination3.95938531
5MP0002653_abnormal_ependyma_morphology3.80652788
6MP0001145_abnormal_male_reproductive3.32090834
7MP0002161_abnormal_fertility/fecundity3.21603359
8MP0000653_abnormal_sex_gland2.88527279
9MP0005623_abnormal_meninges_morphology2.80037448
10MP0001968_abnormal_touch/_nociception2.29333401
11MP0003195_calcinosis2.27125897
12MP0002160_abnormal_reproductive_system2.20647988
13MP0008057_abnormal_DNA_replication2.16805519
14MP0002837_dystrophic_cardiac_calcinosis2.12147820
15MP0000372_irregular_coat_pigmentation2.08650769
16MP0005410_abnormal_fertilization14.5787431
17MP0004885_abnormal_endolymph1.98299474
18MP0005646_abnormal_pituitary_gland1.97926674
19MP0001485_abnormal_pinna_reflex1.88541084
20MP0009745_abnormal_behavioral_response1.74613669
21MP0008872_abnormal_physiological_respon1.68616063
22MP0002938_white_spotting1.67691243
23MP0001529_abnormal_vocalization1.65508844
24MP0001986_abnormal_taste_sensitivity1.61388099
25MP0006292_abnormal_olfactory_placode1.61231509
26MP0001486_abnormal_startle_reflex1.61149290
27MP0002638_abnormal_pupillary_reflex1.59401778
28MP0002735_abnormal_chemical_nociception1.58480982
29MP0001501_abnormal_sleep_pattern1.56609057
30MP0005670_abnormal_white_adipose1.51609396
31MP0010094_abnormal_chromosome_stability1.50366266
32MP0009046_muscle_twitch1.49581366
33MP0004142_abnormal_muscle_tone1.49368967
34MP0002282_abnormal_trachea_morphology1.46213997
35MP0002876_abnormal_thyroid_physiology1.42238638
36MP0003252_abnormal_bile_duct1.41655084
37MP0008058_abnormal_DNA_repair1.41063702
38MP0008789_abnormal_olfactory_epithelium1.39012071
39MP0005174_abnormal_tail_pigmentation1.35964959
40MP0006276_abnormal_autonomic_nervous1.34404944
41MP0000631_abnormal_neuroendocrine_gland1.29102600
42MP0004147_increased_porphyrin_level1.27938422
43MP0003646_muscle_fatigue1.27687924
44MP0008995_early_reproductive_senescence1.26331507
45MP0005647_abnormal_sex_gland1.25838207
46MP0005386_behavior/neurological_phenoty1.25618514
47MP0004924_abnormal_behavior1.25618514
48MP0010386_abnormal_urinary_bladder1.24963710
49MP0003136_yellow_coat_color1.24134104
50MP0005084_abnormal_gallbladder_morpholo1.21321783
51MP0002067_abnormal_sensory_capabilities1.18968738
52MP0005645_abnormal_hypothalamus_physiol1.18124647
53MP0004043_abnormal_pH_regulation1.16520280
54MP0003718_maternal_effect1.15300919
55MP0008007_abnormal_cellular_replicative1.15126473
56MP0005389_reproductive_system_phenotype1.13780066
57MP0002557_abnormal_social/conspecific_i1.13763658
58MP0001984_abnormal_olfaction1.13299793
59MP0001905_abnormal_dopamine_level1.11137982
60MP0002064_seizures1.10115819
61MP0008875_abnormal_xenobiotic_pharmacok1.09369309
62MP0003786_premature_aging1.08964764
63MP0001970_abnormal_pain_threshold1.08612583
64MP0003121_genomic_imprinting1.08251923
65MP0002734_abnormal_mechanical_nocicepti1.07242288
66MP0005075_abnormal_melanosome_morpholog1.07197413
67MP0002095_abnormal_skin_pigmentation1.05964813
68MP0000569_abnormal_digit_pigmentation1.05463340
69MP0000383_abnormal_hair_follicle1.04041205
70MP0002733_abnormal_thermal_nociception1.04002173
71MP0002751_abnormal_autonomic_nervous1.02279677
72MP0004215_abnormal_myocardial_fiber1.00933504
73MP0005195_abnormal_posterior_eye0.96443908
74MP0001764_abnormal_homeostasis0.94850286
75MP0001765_abnormal_ion_homeostasis0.94385904
76MP0004145_abnormal_muscle_electrophysio0.92269034
77MP0001919_abnormal_reproductive_system0.90549723
78MP0002752_abnormal_somatic_nervous0.89454830
79MP0003283_abnormal_digestive_organ0.87675310
80MP0004134_abnormal_chest_morphology0.87435744
81MP0000230_abnormal_systemic_arterial0.87231005
82MP0000026_abnormal_inner_ear0.86080008
83MP0003937_abnormal_limbs/digits/tail_de0.83743517
84MP0003878_abnormal_ear_physiology0.83477621
85MP0005377_hearing/vestibular/ear_phenot0.83477621
86MP0003111_abnormal_nucleus_morphology0.82701845
87MP0005379_endocrine/exocrine_gland_phen0.80249557
88MP0002138_abnormal_hepatobiliary_system0.77695070
89MP0003950_abnormal_plasma_membrane0.77064189
90MP0002184_abnormal_innervation0.76872734
91MP0003011_delayed_dark_adaptation0.71073676
92MP0000358_abnormal_cell_content/0.71045784
93MP0004233_abnormal_muscle_weight0.69989375
94MP0004808_abnormal_hematopoietic_stem0.66344739
95MP0005397_hematopoietic_system_phenotyp0.63034776
96MP0001545_abnormal_hematopoietic_system0.63034776
97MP0010307_abnormal_tumor_latency0.59441932
98MP0009278_abnormal_bone_marrow0.54032840
99MP0003879_abnormal_hair_cell0.53015873
100MP0003699_abnormal_female_reproductive0.52944890
101MP0002102_abnormal_ear_morphology0.48634238
102MP0001293_anophthalmia0.47974827
103MP0002928_abnormal_bile_duct0.47359731
104MP0001119_abnormal_female_reproductive0.46772693
105MP0003115_abnormal_respiratory_system0.46477868
106MP0000427_abnormal_hair_cycle0.46386653
107MP0001730_embryonic_growth_arrest0.44175488
108MP0003077_abnormal_cell_cycle0.43545422
109MP0003861_abnormal_nervous_system0.41991490
110MP0002152_abnormal_brain_morphology0.41315936
111MP0002234_abnormal_pharynx_morphology0.41012162
112MP0001851_eye_inflammation0.38404564
113MP0005391_vision/eye_phenotype0.38109494
114MP0000778_abnormal_nervous_system0.37732548
115MP0005551_abnormal_eye_electrophysiolog0.37710988
116MP0004811_abnormal_neuron_physiology0.37230764
117MP0005253_abnormal_eye_physiology0.35800596
118MP0005636_abnormal_mineral_homeostasis0.34310855
119MP0004270_analgesia0.34216930
120MP0003329_amyloid_beta_deposits0.33978789
121MP0001324_abnormal_eye_pigmentation0.33921279
122MP0003787_abnormal_imprinting0.31255420
123MP0000751_myopathy0.31063788
124MP0005666_abnormal_adipose_tissue0.30422551
125MP0000313_abnormal_cell_death0.29749806
126MP0002572_abnormal_emotion/affect_behav0.29688881
127MP0002092_abnormal_eye_morphology0.28947142
128MP0000015_abnormal_ear_pigmentation0.27758924
129MP0001727_abnormal_embryo_implantation0.26474108
130MP0002229_neurodegeneration0.26116531
131MP0003633_abnormal_nervous_system0.25895863
132MP0006072_abnormal_retinal_apoptosis0.24127982
133MP0002084_abnormal_developmental_patter0.24080386
134MP0001440_abnormal_grooming_behavior0.23998699
135MP0009115_abnormal_fat_cell0.23919505
136MP0004036_abnormal_muscle_relaxation0.23343102
137MP0002063_abnormal_learning/memory/cond0.22776763
138MP0005076_abnormal_cell_differentiation0.22482360
139MP0003631_nervous_system_phenotype0.22328540
140MP0003635_abnormal_synaptic_transmissio0.21825694
141MP0002272_abnormal_nervous_system0.20879216
142MP0005423_abnormal_somatic_nervous0.20720625
143MP0003880_abnormal_central_pattern0.20153280
144MP0003693_abnormal_embryo_hatching0.19912275
145MP0008569_lethality_at_weaning0.19713518
146MP0005394_taste/olfaction_phenotype0.19105490
147MP0005499_abnormal_olfactory_system0.19105490
148MP0001672_abnormal_embryogenesis/_devel0.18346842
149MP0005380_embryogenesis_phenotype0.18346842
150MP0004019_abnormal_vitamin_homeostasis0.17876756
151MP0000955_abnormal_spinal_cord0.17826865
152MP0002736_abnormal_nociception_after0.17629104
153MP0000534_abnormal_ureter_morphology0.17527237
154MP0004133_heterotaxia0.17317921
155MP0002971_abnormal_brown_adipose0.17163999
156MP0002882_abnormal_neuron_morphology0.16889803
157MP0004742_abnormal_vestibular_system0.16842226
158MP0004859_abnormal_synaptic_plasticity0.16624545
159MP0001963_abnormal_hearing_physiology0.16383614

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.42004055
2Abnormal respiratory motile cilium morphology (HP:0005938)8.66666563
3Abnormal respiratory epithelium morphology (HP:0012253)8.66666563
4Rhinitis (HP:0012384)8.13325268
5Abnormal ciliary motility (HP:0012262)7.69963734
6Chronic bronchitis (HP:0004469)6.95564434
7Nasal polyposis (HP:0100582)6.31041089
8Infertility (HP:0000789)6.06810958
9Abnormality of the nasal mucosa (HP:0000433)5.13078101
10Nephronophthisis (HP:0000090)4.71475635
11Bronchiectasis (HP:0002110)4.69821610
12Bronchitis (HP:0012387)4.45224383
13Pancreatic cysts (HP:0001737)4.30932182
14Abnormality of the lower motor neuron (HP:0002366)4.16860584
15True hermaphroditism (HP:0010459)3.85850707
16Congenital stationary night blindness (HP:0007642)3.72690294
17Abnormality of the renal medulla (HP:0100957)3.68816482
18Recurrent otitis media (HP:0000403)3.34993248
19Recurrent sinusitis (HP:0011108)3.28710906
20Amyotrophic lateral sclerosis (HP:0007354)3.27882543
21Tubulointerstitial nephritis (HP:0001970)3.26890434
22Gonadotropin excess (HP:0000837)3.21033570
23Hyperventilation (HP:0002883)3.18819884
24Chronic hepatic failure (HP:0100626)3.15932061
25Attenuation of retinal blood vessels (HP:0007843)2.94088722
26Type II lissencephaly (HP:0007260)2.94030962
27Male infertility (HP:0003251)2.91801402
28Fibular hypoplasia (HP:0003038)2.85010487
29Recurrent bronchitis (HP:0002837)2.78331016
30Molar tooth sign on MRI (HP:0002419)2.76131350
31Abnormality of midbrain morphology (HP:0002418)2.76131350
32Abolished electroretinogram (ERG) (HP:0000550)2.70678146
33Abnormal spermatogenesis (HP:0008669)2.69650438
34Progressive cerebellar ataxia (HP:0002073)2.69094614
35Intestinal atresia (HP:0011100)2.62112615
36Inability to walk (HP:0002540)2.55994255
37Febrile seizures (HP:0002373)2.54381233
38Pendular nystagmus (HP:0012043)2.53093969
39Abnormal rod and cone electroretinograms (HP:0008323)2.51420250
40Impaired proprioception (HP:0010831)2.49777692
41Renal cortical cysts (HP:0000803)2.49533010
42Tubulointerstitial abnormality (HP:0001969)2.49175023
43Keratoconus (HP:0000563)2.48453636
44Increased corneal curvature (HP:0100692)2.48453636
45Medial flaring of the eyebrow (HP:0010747)2.42696161
46Hypothermia (HP:0002045)2.40577365
47Abnormality of the labia minora (HP:0012880)2.39111082
48Tubular atrophy (HP:0000092)2.38819187
49Absent speech (HP:0001344)2.38131115
50Genetic anticipation (HP:0003743)2.36773511
51Cerebellar dysplasia (HP:0007033)2.35623282
52Upper motor neuron abnormality (HP:0002127)2.34940098
53Broad-based gait (HP:0002136)2.34255936
54Hypoplasia of the capital femoral epiphysis (HP:0003090)2.31381547
55Lissencephaly (HP:0001339)2.30019187
56Progressive inability to walk (HP:0002505)2.28100517
57Postaxial foot polydactyly (HP:0001830)2.27100405
58Impulsivity (HP:0100710)2.26443506
59Hypoplasia of the fovea (HP:0007750)2.25254304
60Aplasia/Hypoplasia of the fovea (HP:0008060)2.25254304
61Polyuria (HP:0000103)2.24274612
62Degeneration of anterior horn cells (HP:0002398)2.23615056
63Abnormality of the anterior horn cell (HP:0006802)2.23615056
64Congenital sensorineural hearing impairment (HP:0008527)2.23269394
65Fair hair (HP:0002286)2.19392254
66Furrowed tongue (HP:0000221)2.18030924
67Nephrogenic diabetes insipidus (HP:0009806)2.17676052
68Decreased central vision (HP:0007663)2.16255439
69Absent frontal sinuses (HP:0002688)2.16251118
70Protruding tongue (HP:0010808)2.14400788
71J-shaped sella turcica (HP:0002680)2.14130767
72Bony spicule pigmentary retinopathy (HP:0007737)2.12759735
73Sclerocornea (HP:0000647)2.12160244
74Genital tract atresia (HP:0001827)2.10480094
75Stomach cancer (HP:0012126)2.09669822
76Optic nerve hypoplasia (HP:0000609)2.08494535
77Absent rod-and cone-mediated responses on ERG (HP:0007688)2.08401671
78Aplasia/Hypoplasia of the tibia (HP:0005772)2.07740676
79Stage 5 chronic kidney disease (HP:0003774)2.06309060
80Azoospermia (HP:0000027)2.05616776
81Abnormality of macular pigmentation (HP:0008002)2.01533382
82Short ribs (HP:0000773)2.00069800
83Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.6863326
84Dynein arm defect of respiratory motile cilia (HP:0012255)12.1906098
85Absent/shortened dynein arms (HP:0200106)12.1906098
86Thyroid-stimulating hormone excess (HP:0002925)1.99543207
87Chorioretinal atrophy (HP:0000533)1.98088395
88Vaginal atresia (HP:0000148)1.97757714
89Congenital hepatic fibrosis (HP:0002612)1.97313449
90Thyroiditis (HP:0100646)1.97064947
91Drooling (HP:0002307)1.96862577
92Anencephaly (HP:0002323)1.94413723
93Limb dystonia (HP:0002451)1.94110478
943-Methylglutaconic aciduria (HP:0003535)1.91975412
95Abnormality of the renal cortex (HP:0011035)1.91036750
96Male pseudohermaphroditism (HP:0000037)1.90280756
97Large for gestational age (HP:0001520)1.90271368
98Abnormality of the dental root (HP:0006486)1.88926196
99Taurodontia (HP:0000679)1.88926196
100Abnormality of permanent molar morphology (HP:0011071)1.88926196
101Microglossia (HP:0000171)1.88908877
102Supernumerary spleens (HP:0009799)1.88520203
103Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.87783023
104Oculomotor apraxia (HP:0000657)1.86469247
105Hemiparesis (HP:0001269)1.85497233
106Abnormality of dentin (HP:0010299)1.85344084
107Patellar aplasia (HP:0006443)1.85109689
108Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.83860800
109Absent epiphyses (HP:0010577)1.83860800
110Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.83364826
111Abnormality of alanine metabolism (HP:0010916)1.83364826
112Hyperalaninemia (HP:0003348)1.83364826
113Abnormality of the fovea (HP:0000493)1.82847102
114Aplasia/Hypoplasia of the fibula (HP:0006492)1.82820185
115Renal dysplasia (HP:0000110)1.80560568
116Small hand (HP:0200055)1.78293353
117Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.77993610
118Abnormality of molar morphology (HP:0011070)1.77045207
119Abnormality of molar (HP:0011077)1.77045207
120Focal seizures (HP:0007359)1.76953234
121Abnormal urine output (HP:0012590)1.76919423
122Decreased electroretinogram (ERG) amplitude (HP:0000654)1.76896161
123Albinism (HP:0001022)1.76777974
124Aplasia/Hypoplasia of the uvula (HP:0010293)1.76377631
125Tubulointerstitial fibrosis (HP:0005576)1.76332568
126Occipital encephalocele (HP:0002085)1.75827034
127Increased CSF lactate (HP:0002490)1.75607483
128Retinitis pigmentosa (HP:0000510)1.75234049
129Progressive macrocephaly (HP:0004481)1.74121520
130Excessive salivation (HP:0003781)1.74037857
131Astigmatism (HP:0000483)1.73980379
132Aplasia/Hypoplasia of the patella (HP:0006498)1.73895872
133Mitochondrial inheritance (HP:0001427)1.73467828
13411 pairs of ribs (HP:0000878)1.73302711
135Generalized hypopigmentation of hair (HP:0011358)1.72469118
136Spastic tetraparesis (HP:0001285)1.71309986
137Heterotopia (HP:0002282)1.70052836
138Facial cleft (HP:0002006)1.69747085
139Abnormality of the dental pulp (HP:0006479)1.69131933
140Abnormal drinking behavior (HP:0030082)1.68006840
141Polydipsia (HP:0001959)1.68006840
142Postaxial hand polydactyly (HP:0001162)1.67105045
143Chronic sinusitis (HP:0011109)1.66913176
144Conjunctival telangiectasia (HP:0000524)1.60130181
145Aplasia/Hypoplasia of the tongue (HP:0010295)1.59206122
146Median cleft lip (HP:0000161)1.58910682
147Short thorax (HP:0010306)1.58607205
148Bell-shaped thorax (HP:0001591)1.57916049
149Deformed sella turcica (HP:0002681)1.57351501
150Cystic liver disease (HP:0006706)1.55662162
151Pancreatic fibrosis (HP:0100732)1.51141529
152Broad distal phalanx of finger (HP:0009836)1.50906425
153Abnormality of ocular smooth pursuit (HP:0000617)1.50352158
154Breast carcinoma (HP:0003002)1.48776515
155Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.48644923
156Abnormal biliary tract physiology (HP:0012439)1.48119193
157Bile duct proliferation (HP:0001408)1.48119193
158Gaze-evoked nystagmus (HP:0000640)1.47783600
159Decreased motor nerve conduction velocity (HP:0003431)1.45026811
160Abnormality of renal excretion (HP:0011036)1.39377001
161Gait imbalance (HP:0002141)1.35663421
162Nephropathy (HP:0000112)1.33417939
163Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.32928880
164Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.32749965
165Congenital primary aphakia (HP:0007707)1.32219339
166Pachygyria (HP:0001302)1.30560165
167Abnormal gallbladder physiology (HP:0012438)1.29711066
168Cholecystitis (HP:0001082)1.29711066
169Atrophy/Degeneration involving motor neurons (HP:0007373)1.28945845
170Hypoplasia of dental enamel (HP:0006297)1.27993538
171Short nail (HP:0001799)1.27983378
172Large eyes (HP:0001090)1.27803848
173Selective tooth agenesis (HP:0001592)1.27739282
174Short femoral neck (HP:0100864)1.24543443

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK39.06388839
2PDK49.06388839
3PDK25.85757420
4TESK14.10365241
5PRKD33.34743181
6PNCK3.13241018
7ICK2.84526135
8MAP4K22.71481516
9CASK2.70760708
10STK392.67245127
11ADRBK22.63572617
12WNK42.53420841
13PTK2B2.47787904
14MAPK132.40999250
15NUAK12.12844116
16TRIM282.06685054
17ACVR1B2.06221863
18ZAK1.97295155
19NEK21.92388998
20GRK11.85135726
21INSRR1.76682984
22TAOK31.68550486
23BCR1.60759217
24TNIK1.54964349
25WNK11.33863392
26MKNK21.32266552
27STK381.30618240
28PAK31.27652439
29CDC71.21990119
30TLK11.19147194
31ERBB31.18744391
32MAPK151.08050839
33TXK1.07164272
34CCNB11.05291715
35DYRK21.03214940
36DAPK21.02647168
37VRK11.01885382
38ADRBK10.97820033
39STK30.97384107
40PRKCE0.93537598
41TNK20.90689443
42CAMK1G0.88593006
43TYRO30.88312050
44CSNK1G20.86416681
45WEE10.84486282
46CSNK1G10.82477772
47PASK0.80702828
48PDK10.80389252
49EPHA40.79611167
50MST40.79209164
51DYRK1B0.78402160
52TTK0.78063745
53CSNK1G30.77928081
54PKN10.76010963
55MINK10.67020649
56TGFBR10.63447017
57PINK10.63202833
58CSNK1A1L0.63147913
59BMPR1B0.61378470
60MAP3K120.60955402
61TEC0.60142640
62ATR0.59904923
63SGK20.59056421
64CHEK10.58978369
65CHEK20.56248948
66PIK3CG0.56092900
67PLK30.53423052
68KIT0.52299728
69MKNK10.51988987
70FLT30.51055707
71DYRK30.50426082
72CDK120.50067235
73TAF10.50028248
74EIF2AK30.48674690
75DYRK1A0.48453087
76PHKG10.48433870
77PHKG20.48433870
78FER0.48358665
79PLK40.45355966
80CSNK1A10.42989760
81CAMKK20.42842819
82BCKDK0.42818903
83IRAK10.41687775
84ATM0.41410223
85IKBKB0.41160045
86LMTK20.40690260
87PRKACA0.39271689
88MAPKAPK30.38069665
89GRK50.37880298
90CDK190.36574614
91VRK20.36422570
92RPS6KA50.36301758
93PIK3CA0.35873852
94STK38L0.35767439
95PLK10.33937823
96NTRK20.33858117
97TESK20.33444023
98GRK70.32450277
99MTOR0.32396507
100AKT30.32381625
101EEF2K0.32298966
102SIK20.31826392
103CAMKK10.31326809
104SGK2230.31303964
105SGK4940.31303964
106ABL10.30810541
107MAP3K40.28617508
108PRKCG0.27130335
109MARK20.26632942
110PAK10.25696292
111RPS6KB10.25428298
112CDK30.23657533
113PRKAA10.23549441
114PDPK10.20159403
115MAP2K70.19102401
116NEK60.17837393
117MARK10.17350324
118MAPKAPK50.16864085
119MAP2K60.12406582
120BRSK20.12398527
121CDK10.12089665
122PAK20.10427070
123MUSK0.10154535
124CSNK1D0.09961190
125PAK60.09892138
126BRAF0.09238865
127CDK150.09084310
128FRK0.09018196
129GSK3B0.08899493
130CDK20.08702909
131PRKG10.08576882
132PRKCQ0.08277140
133STK110.08102053
134CDK180.08061446
135PRKACB0.07176376
136MAPK80.06542145
137IRAK20.06410830
138MAP3K100.06325493
139CDK11A0.06121844
140PRKDC0.05395957
141TAOK10.05328996
142BRSK10.03759402
143PRKCB0.03218106
144CAMK2A0.03149285
145OXSR10.02856809
146CDK140.02759552
147MAPK100.02628135
148CSNK2A10.02451363
149RPS6KA30.02044958
150CSNK2A20.01039284
151FGFR20.01013434
152RIPK40.00900336
153PRKCZ0.00359410
154WNK30.00054824
155CDK4-0.0303511
156AURKA-0.0260922
157PLK2-0.0257972
158MAPK14-0.0254726
159CSNK1E-0.0251052
160NTRK3-0.0200136
161RPS6KA1-0.0189818
162MAPK1-0.0123325
163MARK3-0.0115326
164PRKACG-0.0081376

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.02732398
2Pyruvate metabolism_Homo sapiens_hsa006204.17361492
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.74742935
4Dorso-ventral axis formation_Homo sapiens_hsa043203.31942167
5Propanoate metabolism_Homo sapiens_hsa006403.11088761
6Phototransduction_Homo sapiens_hsa047442.94497037
7Fanconi anemia pathway_Homo sapiens_hsa034602.92135422
8Glucagon signaling pathway_Homo sapiens_hsa049222.90159850
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.87403181
10Basal transcription factors_Homo sapiens_hsa030222.78606581
11Butanoate metabolism_Homo sapiens_hsa006502.77460853
12Fatty acid biosynthesis_Homo sapiens_hsa000612.63907264
13Nitrogen metabolism_Homo sapiens_hsa009102.41848199
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.37942304
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.36744416
16Oocyte meiosis_Homo sapiens_hsa041142.36619150
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.33112874
18Pentose phosphate pathway_Homo sapiens_hsa000302.28321659
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.19609042
20Huntingtons disease_Homo sapiens_hsa050162.17856443
21Maturity onset diabetes of the young_Homo sapiens_hsa049502.15411571
22Selenocompound metabolism_Homo sapiens_hsa004502.13113019
23Linoleic acid metabolism_Homo sapiens_hsa005912.10766581
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.03847394
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.01977453
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.01200434
27Protein export_Homo sapiens_hsa030601.99079694
28Amphetamine addiction_Homo sapiens_hsa050311.90247553
29mRNA surveillance pathway_Homo sapiens_hsa030151.88280200
30Glycerolipid metabolism_Homo sapiens_hsa005611.84736886
31Primary bile acid biosynthesis_Homo sapiens_hsa001201.84591035
32RNA polymerase_Homo sapiens_hsa030201.64586733
33Tryptophan metabolism_Homo sapiens_hsa003801.63550555
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.63201841
35Renin secretion_Homo sapiens_hsa049241.57811297
36Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.54463343
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.54351333
38Oxidative phosphorylation_Homo sapiens_hsa001901.52301072
39Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.52044071
40RNA transport_Homo sapiens_hsa030131.50599587
41Carbohydrate digestion and absorption_Homo sapiens_hsa049731.45477506
42Caffeine metabolism_Homo sapiens_hsa002321.41536888
43Steroid hormone biosynthesis_Homo sapiens_hsa001401.40989084
44Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.38590218
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.36358515
46Glycosaminoglycan degradation_Homo sapiens_hsa005311.35946413
47Long-term potentiation_Homo sapiens_hsa047201.29238988
48GABAergic synapse_Homo sapiens_hsa047271.27530661
49Glycerophospholipid metabolism_Homo sapiens_hsa005641.26002887
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.22748440
51Non-homologous end-joining_Homo sapiens_hsa034501.20134837
52PPAR signaling pathway_Homo sapiens_hsa033201.19917953
53Peroxisome_Homo sapiens_hsa041461.18015595
54Parkinsons disease_Homo sapiens_hsa050121.17988685
55Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.17625667
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.16668735
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.15322740
58Serotonergic synapse_Homo sapiens_hsa047261.11313104
59Retinol metabolism_Homo sapiens_hsa008301.07608443
60Fructose and mannose metabolism_Homo sapiens_hsa000511.07475815
61Regulation of autophagy_Homo sapiens_hsa041401.06099129
62Purine metabolism_Homo sapiens_hsa002301.06083005
63Cardiac muscle contraction_Homo sapiens_hsa042601.01219624
64Carbon metabolism_Homo sapiens_hsa012001.00632875
65ABC transporters_Homo sapiens_hsa020101.00564544
66Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.98492774
67Ether lipid metabolism_Homo sapiens_hsa005650.94190716
68Antigen processing and presentation_Homo sapiens_hsa046120.92904429
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.92030182
70Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.91953829
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.85999145
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.83750608
73Estrogen signaling pathway_Homo sapiens_hsa049150.83278299
74Calcium signaling pathway_Homo sapiens_hsa040200.80619615
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77694273
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.77551719
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77077354
78Mineral absorption_Homo sapiens_hsa049780.76124406
79Circadian entrainment_Homo sapiens_hsa047130.73566763
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72814428
81beta-Alanine metabolism_Homo sapiens_hsa004100.72287122
82Alzheimers disease_Homo sapiens_hsa050100.71125967
83Olfactory transduction_Homo sapiens_hsa047400.70979645
84Circadian rhythm_Homo sapiens_hsa047100.70750352
85One carbon pool by folate_Homo sapiens_hsa006700.69810194
86Taste transduction_Homo sapiens_hsa047420.68228532
87RNA degradation_Homo sapiens_hsa030180.67991364
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66926405
89Ovarian steroidogenesis_Homo sapiens_hsa049130.66420538
90Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.65125206
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64906878
92Intestinal immune network for IgA production_Homo sapiens_hsa046720.64089217
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62273461
94Sulfur metabolism_Homo sapiens_hsa009200.62133359
95Cell cycle_Homo sapiens_hsa041100.61795634
96Insulin secretion_Homo sapiens_hsa049110.61152258
97Inositol phosphate metabolism_Homo sapiens_hsa005620.61143844
98Cocaine addiction_Homo sapiens_hsa050300.59106274
99N-Glycan biosynthesis_Homo sapiens_hsa005100.58489562
100VEGF signaling pathway_Homo sapiens_hsa043700.57483751
101Glutamatergic synapse_Homo sapiens_hsa047240.56977023
102Synaptic vesicle cycle_Homo sapiens_hsa047210.56698022
103Central carbon metabolism in cancer_Homo sapiens_hsa052300.56429834
104Fatty acid metabolism_Homo sapiens_hsa012120.56349140
105Biosynthesis of amino acids_Homo sapiens_hsa012300.55788006
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54359747
107Endocytosis_Homo sapiens_hsa041440.53955734
108Fat digestion and absorption_Homo sapiens_hsa049750.53343319
109Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53092332
110Morphine addiction_Homo sapiens_hsa050320.50806504
111Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50635618
112Primary immunodeficiency_Homo sapiens_hsa053400.50390065
113Long-term depression_Homo sapiens_hsa047300.48939928
114SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48558950
115Arachidonic acid metabolism_Homo sapiens_hsa005900.47839386
116Collecting duct acid secretion_Homo sapiens_hsa049660.46395990
117AMPK signaling pathway_Homo sapiens_hsa041520.45494735
118Cholinergic synapse_Homo sapiens_hsa047250.44183997
119Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44085231
120Histidine metabolism_Homo sapiens_hsa003400.42778681
121Dopaminergic synapse_Homo sapiens_hsa047280.42707560
122Steroid biosynthesis_Homo sapiens_hsa001000.41347188
123Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40471717
124Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40438247
125Homologous recombination_Homo sapiens_hsa034400.39091739
126Gastric acid secretion_Homo sapiens_hsa049710.38265732
127Pyrimidine metabolism_Homo sapiens_hsa002400.38119215
128Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37675403
129Salivary secretion_Homo sapiens_hsa049700.37569779
130Systemic lupus erythematosus_Homo sapiens_hsa053220.37547871
131cAMP signaling pathway_Homo sapiens_hsa040240.36868973
132Sphingolipid metabolism_Homo sapiens_hsa006000.36132091
133Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.35831018
134Hedgehog signaling pathway_Homo sapiens_hsa043400.34491185
135Fatty acid degradation_Homo sapiens_hsa000710.33237610
136Vascular smooth muscle contraction_Homo sapiens_hsa042700.33068584
137Oxytocin signaling pathway_Homo sapiens_hsa049210.32635917
138Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.32316341
139Nicotine addiction_Homo sapiens_hsa050330.32014794
140Proteasome_Homo sapiens_hsa030500.31157627
141Glutathione metabolism_Homo sapiens_hsa004800.28947224
142Wnt signaling pathway_Homo sapiens_hsa043100.28933423
143Viral carcinogenesis_Homo sapiens_hsa052030.28910960
144Alcoholism_Homo sapiens_hsa050340.27410110
145Legionellosis_Homo sapiens_hsa051340.26980495
146Adipocytokine signaling pathway_Homo sapiens_hsa049200.26773392
147Thyroid hormone synthesis_Homo sapiens_hsa049180.26557487
148Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26540959
149B cell receptor signaling pathway_Homo sapiens_hsa046620.26194413
150Type II diabetes mellitus_Homo sapiens_hsa049300.24453869
151Chemical carcinogenesis_Homo sapiens_hsa052040.24441099
152Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23292344
153Metabolic pathways_Homo sapiens_hsa011000.20219420
154Aldosterone synthesis and secretion_Homo sapiens_hsa049250.19661895
155Pancreatic secretion_Homo sapiens_hsa049720.18370834

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