EEF2K

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links activation of cell surface receptors to cell division. This kinase is involved in the regulation of protein synthesis. It phosphorylates eukaryotic elongation factor 2 (EEF2) and thus inhibits the EEF2 function. The activity of this kinase is increased in many cancers and may be a valid target for anti-cancer treatment. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)5.07617137
2definitive hemopoiesis (GO:0060216)5.00503438
3megakaryocyte development (GO:0035855)4.92153017
4positive regulation of B cell differentiation (GO:0045579)4.87719227
5actin-myosin filament sliding (GO:0033275)4.67793337
6muscle filament sliding (GO:0030049)4.67793337
7ribosomal small subunit assembly (GO:0000028)4.64611780
8response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.54156141
9antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.50358292
10antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.50358292
11skeletal muscle contraction (GO:0003009)4.43094880
12skeletal muscle adaptation (GO:0043501)4.38239428
133-UTR-mediated mRNA stabilization (GO:0070935)4.31094192
14viral transcription (GO:0019083)4.30717142
15sarcoplasmic reticulum calcium ion transport (GO:0070296)4.19449008
16negative regulation of granulocyte differentiation (GO:0030853)4.10440260
17translational termination (GO:0006415)4.02573632
18actin-mediated cell contraction (GO:0070252)3.99398028
19positive regulation of granulocyte differentiation (GO:0030854)3.99097271
20erythrocyte maturation (GO:0043249)3.97049676
21myofibril assembly (GO:0030239)3.96483664
22striated muscle atrophy (GO:0014891)3.94124164
23regulation of skeletal muscle contraction (GO:0014819)3.92092539
24antigen processing and presentation via MHC class Ib (GO:0002475)3.91333965
25interkinetic nuclear migration (GO:0022027)3.84520980
26regulation of granulocyte differentiation (GO:0030852)3.82554723
27negative regulation of phagocytosis (GO:0050765)3.77755082
28regulation of erythrocyte differentiation (GO:0045646)3.77138070
29positive regulation of gamma-delta T cell activation (GO:0046645)3.76378417
30carnitine shuttle (GO:0006853)3.72994959
31carnitine transmembrane transport (GO:1902603)3.70283645
32desmosome organization (GO:0002934)3.68117751
33positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.60805378
34germ cell migration (GO:0008354)3.55579729
35positive regulation of megakaryocyte differentiation (GO:0045654)3.51656017
36* translational elongation (GO:0006414)3.50860262
37fucose catabolic process (GO:0019317)3.49985728
38L-fucose metabolic process (GO:0042354)3.49985728
39L-fucose catabolic process (GO:0042355)3.49985728
40fatty acid transmembrane transport (GO:1902001)3.46418800
41carnitine transport (GO:0015879)3.42809185
42amino-acid betaine transport (GO:0015838)3.42809185
43striated muscle contraction (GO:0006941)3.42480184
44natural killer cell differentiation (GO:0001779)3.39653160
45negative regulation of fatty acid transport (GO:2000192)3.36551390
46insulin-like growth factor receptor signaling pathway (GO:0048009)3.35102212
47creatine metabolic process (GO:0006600)3.34344265
48execution phase of apoptosis (GO:0097194)3.32203080
49antigen processing and presentation of endogenous antigen (GO:0019883)3.31779686
50myeloid cell development (GO:0061515)3.31203273
51nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.29967345
52iron ion import (GO:0097286)3.28663628
53regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.25787681
54cellular hyperosmotic response (GO:0071474)3.25300927
55embryonic hemopoiesis (GO:0035162)3.24473588
56antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.21906895
57plasma membrane repair (GO:0001778)3.21485479
58positive regulation of histone deacetylation (GO:0031065)3.21297392
59muscle atrophy (GO:0014889)3.21109325
60actin filament-based movement (GO:0030048)3.20346322
61SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.17464704
62establishment of skin barrier (GO:0061436)3.16371291
63cardiac myofibril assembly (GO:0055003)3.15000559
64actomyosin structure organization (GO:0031032)3.12047582
65viral life cycle (GO:0019058)3.09009822
66regulation of histone H3-K27 methylation (GO:0061085)3.07331588
67negative regulation of potassium ion transmembrane transport (GO:1901380)3.07207326
68cilium or flagellum-dependent cell motility (GO:0001539)3.06337712
69negative regulation of stress fiber assembly (GO:0051497)3.04982978
70protein targeting to ER (GO:0045047)3.04970199
71cellular protein complex disassembly (GO:0043624)3.04813000
72regulation of gamma-delta T cell differentiation (GO:0045586)3.03796120
73positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.02934405
74cotranslational protein targeting to membrane (GO:0006613)3.02501684
75negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.02458894
76sarcomere organization (GO:0045214)2.99758983
77angiogenesis involved in wound healing (GO:0060055)2.99374251
78regulation of histone phosphorylation (GO:0033127)2.98905955
79establishment of protein localization to endoplasmic reticulum (GO:0072599)2.97356376
80focal adhesion assembly (GO:0048041)2.97171228
81cell-substrate adherens junction assembly (GO:0007045)2.97171228
82regulation of cholesterol homeostasis (GO:2000188)2.95357208
83protein complex disassembly (GO:0043241)2.94383928
84DNA unwinding involved in DNA replication (GO:0006268)2.93473718
85T cell homeostasis (GO:0043029)2.91341466
86response to inactivity (GO:0014854)2.91010948
87regulation of fatty acid oxidation (GO:0046320)2.90459181
88regulation of monocyte differentiation (GO:0045655)2.89626813
89regulation of water loss via skin (GO:0033561)2.89208853
90regulation of fatty acid beta-oxidation (GO:0031998)2.87195617
91platelet formation (GO:0030220)2.86966084
92positive regulation of natural killer cell differentiation (GO:0032825)2.86918347
93motile cilium assembly (GO:0044458)2.86031752
94secretory granule organization (GO:0033363)2.84575169
95ribosomal small subunit biogenesis (GO:0042274)2.83909582
96translational initiation (GO:0006413)2.82337805
97regulation of female gonad development (GO:2000194)2.82175219
98quaternary ammonium group transport (GO:0015697)2.81840132
99regulation of B cell differentiation (GO:0045577)2.81659389
100glycogen catabolic process (GO:0005980)2.81394767
101positive regulation of erythrocyte differentiation (GO:0045648)2.81180776
102regulation of necroptotic process (GO:0060544)2.80727284
103erythrocyte development (GO:0048821)2.80457577
104hepatocyte apoptotic process (GO:0097284)2.79137273
105protein localization to endoplasmic reticulum (GO:0070972)2.78134489
106response to muscle activity (GO:0014850)2.77087141
107positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.75525740
108regulation of gamma-delta T cell activation (GO:0046643)2.74829093
109regulation of relaxation of muscle (GO:1901077)2.74825085
110muscle contraction (GO:0006936)2.73504646
111negative regulation of necroptotic process (GO:0060546)2.72166214
112dosage compensation (GO:0007549)2.71348935
113striated muscle adaptation (GO:0014888)2.71339638
114Peyers patch development (GO:0048541)2.70898682
115mucosal-associated lymphoid tissue development (GO:0048537)2.70898682
116adherens junction assembly (GO:0034333)2.70631477
117protein localization to chromosome, centromeric region (GO:0071459)2.70603159
118positive regulation of protein deacetylation (GO:0090312)2.69402832
119negative regulation of histone methylation (GO:0031061)2.68743699
120positive regulation of fatty acid oxidation (GO:0046321)2.66512846
121positive regulation of fatty acid beta-oxidation (GO:0032000)2.65830424
122regulation of hypersensitivity (GO:0002883)2.64009670
123protein localization to kinetochore (GO:0034501)2.63904680
124macromolecular complex disassembly (GO:0032984)2.63589071
125cell-substrate junction assembly (GO:0007044)2.62060735
126regulation of RIG-I signaling pathway (GO:0039535)2.61192589
127regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.60991746
128skeletal muscle fiber development (GO:0048741)2.57710793
129cardiac muscle contraction (GO:0060048)2.57155564
130protein-DNA complex disassembly (GO:0032986)2.56142985
131nucleosome disassembly (GO:0006337)2.56142985
132regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.55908795
133positive regulation of gene expression, epigenetic (GO:0045815)2.55630312
134vitamin transmembrane transport (GO:0035461)2.54317850
135regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.53779126
136multicellular organismal water homeostasis (GO:0050891)2.53556523
137histone H3-K36 demethylation (GO:0070544)2.53523710
138myotube cell development (GO:0014904)2.52240939
139cellular extravasation (GO:0045123)2.52077513
140lymphoid progenitor cell differentiation (GO:0002320)2.51640418
141glucan catabolic process (GO:0009251)2.51638428
142lymphocyte homeostasis (GO:0002260)2.50554288
143erythrocyte differentiation (GO:0030218)2.49712205
144RNA stabilization (GO:0043489)2.48999361
145mRNA stabilization (GO:0048255)2.48999361
146positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.48994994
147regulation of natural killer cell differentiation (GO:0032823)2.48568327
148mitotic chromosome condensation (GO:0007076)2.46560933
149regulation of glucose import in response to insulin stimulus (GO:2001273)2.46155474
150DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.45927038
151muscle system process (GO:0003012)2.45704727
152positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.45183747
153peptidyl-lysine dimethylation (GO:0018027)2.44965920
154nuclear-transcribed mRNA catabolic process (GO:0000956)2.44812904
155chemical homeostasis within a tissue (GO:0048875)2.44777678
156mRNA catabolic process (GO:0006402)2.44681486
157mitotic sister chromatid cohesion (GO:0007064)2.42984523
1582-oxoglutarate metabolic process (GO:0006103)2.41794940
159mannose metabolic process (GO:0006013)2.41232748
160cytoskeletal anchoring at plasma membrane (GO:0007016)2.40516372
161immunoglobulin mediated immune response (GO:0016064)2.40448520
162negative regulation of protein localization to cell surface (GO:2000009)2.40225143
163positive regulation of lamellipodium organization (GO:1902745)2.39228097
164B cell receptor signaling pathway (GO:0050853)2.38984208
165myotube differentiation (GO:0014902)2.36862467
166cellular polysaccharide catabolic process (GO:0044247)2.36158036
167mitochondrial genome maintenance (GO:0000002)2.36048811
168DNA damage response, signal transduction resulting in transcription (GO:0042772)2.34805254
169ethanol metabolic process (GO:0006067)2.34797908
170negative regulation of RNA splicing (GO:0033119)2.33941086
171protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.33257120
172regulation of histone H3-K9 methylation (GO:0051570)2.33150315
173platelet dense granule organization (GO:0060155)2.32970681
174biotin metabolic process (GO:0006768)2.32800441
175skeletal muscle tissue development (GO:0007519)2.32738564
176macroautophagy (GO:0016236)2.32009801
177import into cell (GO:0098657)2.31527585
178response to muramyl dipeptide (GO:0032495)2.30241646
179positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.29992746
180epithelial cell-cell adhesion (GO:0090136)2.29271967
181coronary vasculature morphogenesis (GO:0060977)2.28142621
182regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.27769459
183myoblast fusion (GO:0007520)2.23372128
184surfactant homeostasis (GO:0043129)2.23285925
185vascular endothelial growth factor signaling pathway (GO:0038084)2.21642517
186negative regulation of potassium ion transport (GO:0043267)2.21438194
187positive regulation of cation channel activity (GO:2001259)2.20229168
188muscle structure development (GO:0061061)2.19969470
189muscle organ development (GO:0007517)2.19905807
190cellular response to ethanol (GO:0071361)2.18818331
191regulation of protein polyubiquitination (GO:1902914)2.17834655
192positive regulation of DNA-templated transcription, initiation (GO:2000144)2.16064303
193retina vasculature morphogenesis in camera-type eye (GO:0061299)2.15693173
194muscle adaptation (GO:0043500)2.15526594
195lung epithelium development (GO:0060428)2.15411792
196positive regulation of myotube differentiation (GO:0010831)2.15007527
197polysaccharide catabolic process (GO:0000272)2.14461733
198dicarboxylic acid biosynthetic process (GO:0043650)2.13428246

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.75861417
2SCL_19346495_ChIP-Seq_HPC-7_Human4.80047966
3MYC_22102868_ChIP-Seq_BL_Human3.90699287
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.54355114
5VDR_21846776_ChIP-Seq_THP-1_Human3.51293394
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.25537667
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.08885768
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.05896762
9TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.99061920
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.88039622
11ESR2_21235772_ChIP-Seq_MCF-7_Human2.87278300
12TCF7_22412390_ChIP-Seq_EML_Mouse2.82559645
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.56644278
14* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.47842420
15VDR_24763502_ChIP-Seq_THP-1_Human2.36820080
16* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.34651048
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.32409322
18DROSHA_22980978_ChIP-Seq_HELA_Human2.31510803
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.21745804
20ESR1_20079471_ChIP-ChIP_T-47D_Human2.19752381
21TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.18055704
22ZNF217_24962896_ChIP-Seq_MCF-7_Human2.17028545
23BP1_19119308_ChIP-ChIP_Hs578T_Human2.09885293
24UTX_26944678_Chip-Seq_JUKART_Human2.08535244
25RUNX1_22412390_ChIP-Seq_EML_Mouse2.08105498
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.05790464
27STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.04861500
28* GATA1_19941827_ChIP-Seq_MEL_Mouse1.97961792
29MAF_26560356_Chip-Seq_TH1_Human1.95982151
30KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.95347271
31TBX20_22328084_ChIP-Seq_HEART_Mouse1.95078501
32TBX20_22080862_ChIP-Seq_HEART_Mouse1.95078501
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.94848495
34CTNNB1_20460455_ChIP-Seq_HCT116_Human1.92799140
35TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.91931204
36BRD4_27068464_Chip-Seq_AML-cells_Mouse1.91659284
37* FOXA2_19822575_ChIP-Seq_HepG2_Human1.91075507
38ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.89598300
39GATA1_22383799_ChIP-Seq_G1ME_Mouse1.89223657
40TP63_17297297_ChIP-ChIP_HaCaT_Human1.86106277
41AHR_22903824_ChIP-Seq_MCF-7_Human1.85838473
42* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.85836333
43LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.82418965
44MYB_26560356_Chip-Seq_TH2_Human1.80150758
45EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80060162
46* KDM2B_26808549_Chip-Seq_DND41_Human1.79132795
47ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.78296945
48* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77470073
49* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.77018047
50ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.74924048
51* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.74607147
52CIITA_25753668_ChIP-Seq_RAJI_Human1.73579223
53* RUNX1_27514584_Chip-Seq_MCF-7_Human1.73397803
54* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.72635793
55FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.72596115
56LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.71382667
57SPI1_23127762_ChIP-Seq_K562_Human1.68163226
58ELK3_25401928_ChIP-Seq_HUVEC_Human1.67976406
59E2F4_17652178_ChIP-ChIP_JURKAT_Human1.67861133
60* SPI1_23547873_ChIP-Seq_NB4_Human1.67763123
61GATA2_22383799_ChIP-Seq_G1ME_Mouse1.66181516
62SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.63956435
63LXR_22158963_ChIP-Seq_LIVER_Mouse1.60258333
64NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.56242469
65MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.55847921
66VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.55164954
67HIF1A_21447827_ChIP-Seq_MCF-7_Human1.55079262
68MYB_26560356_Chip-Seq_TH1_Human1.54902595
69STAT6_21828071_ChIP-Seq_BEAS2B_Human1.54748577
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.52902599
71* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.52103993
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.51931434
73CDX2_19796622_ChIP-Seq_MESCs_Mouse1.51175759
74ZNF263_19887448_ChIP-Seq_K562_Human1.50596283
75PPARA_22158963_ChIP-Seq_LIVER_Mouse1.50351739
76* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.49951398
77SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.47963979
78BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.44796676
79RUNX_20019798_ChIP-Seq_JUKART_Human1.44340978
80NFIB_24661679_ChIP-Seq_LUNG_Mouse1.42601916
81* AR_21572438_ChIP-Seq_LNCaP_Human1.41463074
82GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.41205279
83SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.40244264
84ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.38765396
85EZH2_22144423_ChIP-Seq_EOC_Human1.35136212
86TP53_16413492_ChIP-PET_HCT116_Human1.35093003
87RXR_22158963_ChIP-Seq_LIVER_Mouse1.34220062
88E2F1_21310950_ChIP-Seq_MCF-7_Human1.33813965
89TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.33065931
90GATA1_19941826_ChIP-Seq_K562_Human1.32744168
91* SMC4_20622854_ChIP-Seq_HELA_Human1.31822671
92PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.31162474
93TP53_23651856_ChIP-Seq_MEFs_Mouse1.30628875
94EP300_21415370_ChIP-Seq_HL-1_Mouse1.28820712
95TP63_22573176_ChIP-Seq_HFKS_Human1.28759102
96SOX2_27498859_Chip-Seq_STOMACH_Mouse1.27460990
97IRF8_22096565_ChIP-ChIP_GC-B_Human1.24824921
98* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24546183
99ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.21402085
100CLOCK_20551151_ChIP-Seq_293T_Human1.20351007
101RARG_19884340_ChIP-ChIP_MEFs_Mouse1.20292800
102* KDM2B_26808549_Chip-Seq_JURKAT_Human1.19562239
103ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.18972764
104TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18961915
105ERG_20887958_ChIP-Seq_HPC-7_Mouse1.18366716
106* GATA2_19941826_ChIP-Seq_K562_Human1.16954295
107* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.16598962
108FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16547057
109MAF_26560356_Chip-Seq_TH2_Human1.16021676
110IRF8_27001747_Chip-Seq_BMDM_Mouse1.14624991
111* ETS1_22383799_ChIP-Seq_G1ME_Mouse1.14560810
112P63_26484246_Chip-Seq_KERATINOCYTES_Human1.14029411
113* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13638062
114SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13218495
115FOXO3_23340844_ChIP-Seq_DLD1_Human1.13094469
116HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12949827
117GATA1_22025678_ChIP-Seq_K562_Human1.12129784
118FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.11778616
119RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11640719
120GATA6_25053715_ChIP-Seq_YYC3_Human1.11301931
121EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.10723882
122TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10545694
123CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.09850666
124ATF3_27146783_Chip-Seq_COLON_Human1.08878345
125* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.08722914
126NCOR1_26117541_ChIP-Seq_K562_Human1.07170721
127IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.07151293
128TRIM28_21343339_ChIP-Seq_HEK293_Human1.06718957
129* HNF4A_19822575_ChIP-Seq_HepG2_Human1.06650832
130* MITF_21258399_ChIP-Seq_MELANOMA_Human1.06170044
131LXR_22292898_ChIP-Seq_THP-1_Human1.05350231
132CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.05282680
133* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04971150
134TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04573208
135NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.04504593
136TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04273980
137CREB1_26743006_Chip-Seq_LNCaP_Human1.02742790
138GATA2_21666600_ChIP-Seq_HMVEC_Human1.01950863
139NOTCH1_21737748_ChIP-Seq_TLL_Human1.01597083
140PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.00323516
141FOXA1_25552417_ChIP-Seq_VCAP_Human0.99263693
142MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.99004276
143* P68_20966046_ChIP-Seq_HELA_Human0.98155260
144STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.97490108
145* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.96881136
146MYC_18555785_ChIP-Seq_MESCs_Mouse0.96554369
147SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96436879
148TP63_23658742_ChIP-Seq_EP156T_Human0.95737426
149MYC_27129775_Chip-Seq_CORNEA_Mouse0.95607704
150* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.94359052
151GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94246890
152* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.92907100
153* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.92643065
154AR_21909140_ChIP-Seq_LNCAP_Human0.90567998
155DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.89826541
156GATA3_27048872_Chip-Seq_THYMUS_Human0.89445942
157MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.88085454
158* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.86609004
159STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.85996954
160ESR1_21235772_ChIP-Seq_MCF-7_Human0.85619174
161ELF1_20517297_ChIP-Seq_JURKAT_Human0.85171889
162RACK7_27058665_Chip-Seq_MCF-7_Human0.84308213
163ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.83092701
164SA1_27219007_Chip-Seq_ERYTHROID_Human0.83065710
165RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82373295
166CTCF_27219007_Chip-Seq_ERYTHROID_Human0.81011967
167SOX9_24532713_ChIP-Seq_HFSC_Mouse0.80613293
168STAT4_19710469_ChIP-ChIP_TH1__Mouse0.79893590
169KDM2B_26808549_Chip-Seq_K562_Human0.79538390
170ELF1_17652178_ChIP-ChIP_JURKAT_Human0.79403724
171RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.79313007
172* CTCF_21964334_Chip-Seq_Bcells_Human0.77834787

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system4.26328482
2MP0004145_abnormal_muscle_electrophysio3.91918027
3MP0004233_abnormal_muscle_weight3.22834325
4MP0004036_abnormal_muscle_relaxation3.08843428
5MP0004084_abnormal_cardiac_muscle3.05075662
6MP0009780_abnormal_chondrocyte_physiolo2.91707601
7MP0004808_abnormal_hematopoietic_stem2.89668056
8MP0000749_muscle_degeneration2.78076207
9MP0003950_abnormal_plasma_membrane2.75525082
10MP0001545_abnormal_hematopoietic_system2.63982345
11MP0005397_hematopoietic_system_phenotyp2.63982345
12MP0000465_gastrointestinal_hemorrhage2.60918334
13MP0009278_abnormal_bone_marrow2.60573501
14MP0003656_abnormal_erythrocyte_physiolo2.56534852
15MP0008438_abnormal_cutaneous_collagen2.45392848
16MP0000747_muscle_weakness2.45247542
17MP0003300_gastrointestinal_ulcer2.41270609
18MP0006054_spinal_hemorrhage2.40726643
19MP0005464_abnormal_platelet_physiology2.33394100
20MP0001873_stomach_inflammation2.29688526
21MP0004087_abnormal_muscle_fiber2.29081921
22MP0000490_abnormal_crypts_of2.28581281
23MP0003693_abnormal_embryo_hatching2.21715849
24MP0005670_abnormal_white_adipose2.19592685
25MP0010094_abnormal_chromosome_stability2.18330554
26MP0004147_increased_porphyrin_level2.16987967
27MP0000759_abnormal_skeletal_muscle2.15850140
28MP0002877_abnormal_melanocyte_morpholog2.09550223
29MP0002108_abnormal_muscle_morphology2.07766266
30MP0006138_congestive_heart_failure2.05044013
31MP0003646_muscle_fatigue2.04351186
32MP0004043_abnormal_pH_regulation2.03491784
33MP0010234_abnormal_vibrissa_follicle2.02219500
34MP0005174_abnormal_tail_pigmentation1.97792680
35MP0002269_muscular_atrophy1.97420330
36MP0005330_cardiomyopathy1.92000839
37MP0005409_darkened_coat_color1.91870114
38MP0003303_peritoneal_inflammation1.91324275
39MP0001661_extended_life_span1.88132696
40MP0005369_muscle_phenotype1.83705480
41MP0002398_abnormal_bone_marrow1.80605889
42MP0010352_gastrointestinal_tract_polyps1.78798431
43MP0003045_fibrosis1.76946355
44MP0002009_preneoplasia1.70892927
45MP0003763_abnormal_thymus_physiology1.70665500
46MP0005620_abnormal_muscle_contractility1.67464670
47MP0008004_abnormal_stomach_pH1.61378331
48MP0003566_abnormal_cell_adhesion1.57804101
49MP0002095_abnormal_skin_pigmentation1.57356546
50MP0002166_altered_tumor_susceptibility1.55292688
51MP0000003_abnormal_adipose_tissue1.53136270
52MP0000383_abnormal_hair_follicle1.51254467
53MP0003705_abnormal_hypodermis_morpholog1.50395057
54MP0008007_abnormal_cellular_replicative1.50323514
55MP0002722_abnormal_immune_system1.49778741
56MP0005375_adipose_tissue_phenotype1.49489250
57MP0000689_abnormal_spleen_morphology1.49271101
58MP0003111_abnormal_nucleus_morphology1.46473679
59MP0010155_abnormal_intestine_physiology1.44106504
60MP0000013_abnormal_adipose_tissue1.44016430
61MP0004381_abnormal_hair_follicle1.43058938
62MP0000685_abnormal_immune_system1.41494062
63MP0002971_abnormal_brown_adipose1.40194027
64MP0005503_abnormal_tendon_morphology1.39102120
65MP0008057_abnormal_DNA_replication1.37631824
66MP0002060_abnormal_skin_morphology1.36279868
67MP0000703_abnormal_thymus_morphology1.35458983
68MP0003077_abnormal_cell_cycle1.35261714
69MP0005167_abnormal_blood-brain_barrier1.35218842
70MP0001800_abnormal_humoral_immune1.34465186
71MP0010368_abnormal_lymphatic_system1.34400231
72MP0002420_abnormal_adaptive_immunity1.33516141
73MP0002102_abnormal_ear_morphology1.32706724
74MP0001819_abnormal_immune_cell1.31586502
75MP0003866_abnormal_defecation1.31179096
76MP0002452_abnormal_antigen_presenting1.30375317
77MP0004185_abnormal_adipocyte_glucose1.29753215
78MP0010678_abnormal_skin_adnexa1.29321530
79MP0000750_abnormal_muscle_regeneration1.29041504
80MP0000716_abnormal_immune_system1.29000708
81MP0005671_abnormal_response_to1.27673715
82MP0000015_abnormal_ear_pigmentation1.27632332
83MP0002019_abnormal_tumor_incidence1.27400587
84MP0002429_abnormal_blood_cell1.26575419
85MP0005075_abnormal_melanosome_morpholog1.23813803
86MP0008775_abnormal_heart_ventricle1.21786935
87MP0002006_tumorigenesis1.21212699
88MP0010307_abnormal_tumor_latency1.17381054
89MP0004130_abnormal_muscle_cell1.14689587
90MP0009333_abnormal_splenocyte_physiolog1.14432917
91MP0004215_abnormal_myocardial_fiber1.12520038
92MP0004947_skin_inflammation1.11905066
93MP0005666_abnormal_adipose_tissue1.10963517
94MP0000343_altered_response_to1.10939336
95MP0009115_abnormal_fat_cell1.10386204
96MP0002972_abnormal_cardiac_muscle1.09342952
97MP0001835_abnormal_antigen_presentation1.09052264
98MP0002332_abnormal_exercise_endurance1.08039455
99MP0002419_abnormal_innate_immunity1.07423827
100MP0002896_abnormal_bone_mineralization1.04968249
101MP0000371_diluted_coat_color1.04451247
102MP0002723_abnormal_immune_serum1.03759247
103MP0001663_abnormal_digestive_system1.02115258
104MP0002796_impaired_skin_barrier0.99717102
105MP0002405_respiratory_system_inflammati0.99713536
106MP0003279_aneurysm0.99634998
107MP0005025_abnormal_response_to0.98097940
108MP0002168_other_aberrant_phenotype0.98028668
109MP0001851_eye_inflammation0.97330982
110MP0004272_abnormal_basement_membrane0.96859321
111MP0004264_abnormal_extraembryonic_tissu0.96223221
112MP0005076_abnormal_cell_differentiation0.95547175
113MP0005451_abnormal_body_composition0.95413968
114MP0003436_decreased_susceptibility_to0.95295132
115MP0000858_altered_metastatic_potential0.94705987
116MP0000350_abnormal_cell_proliferation0.90968773
117MP0001879_abnormal_lymphatic_vessel0.89301986
118MP0000566_synostosis0.89287552
119MP0001216_abnormal_epidermal_layer0.88729851
120MP0000477_abnormal_intestine_morphology0.87842765
121MP0009785_altered_susceptibility_to0.87695628
122MP0001958_emphysema0.87225400
123MP0005275_abnormal_skin_tensile0.87199191
124MP0000751_myopathy0.86692652
125MP0005023_abnormal_wound_healing0.86553787
126MP0002127_abnormal_cardiovascular_syste0.86083921
127MP0001544_abnormal_cardiovascular_syste0.85770995
128MP0005385_cardiovascular_system_phenoty0.85770995
129MP0005501_abnormal_skin_physiology0.84326708
130MP0000767_abnormal_smooth_muscle0.83642276
131MP0009931_abnormal_skin_appearance0.83122372
132MP0003828_pulmonary_edema0.82991004
133MP0001849_ear_inflammation0.82302561
134MP0000579_abnormal_nail_morphology0.81724293
135MP0001845_abnormal_inflammatory_respons0.80791658
136MP0002970_abnormal_white_adipose0.79469959
137MP0000377_abnormal_hair_follicle0.78530528
138MP0005647_abnormal_sex_gland0.78182829
139MP0000266_abnormal_heart_morphology0.76894926
140MP0001119_abnormal_female_reproductive0.76601180
141MP0003699_abnormal_female_reproductive0.76088848
142MP0000733_abnormal_muscle_development0.75483376
143MP0001348_abnormal_lacrimal_gland0.74234958
144MP0010329_abnormal_lipoprotein_level0.74007994
145MP0004858_abnormal_nervous_system0.73887014
146MP0010630_abnormal_cardiac_muscle0.73099456
147MP0000313_abnormal_cell_death0.72041199
148MP0003191_abnormal_cellular_cholesterol0.71547651
149MP0002249_abnormal_larynx_morphology0.70434023
150MP0002089_abnormal_postnatal_growth/wei0.70343452
151MP0005000_abnormal_immune_tolerance0.70109210
152MP0004484_altered_response_of0.69885727
153MP0003453_abnormal_keratinocyte_physiol0.68928306
154MP0003724_increased_susceptibility_to0.68855291
155MP0005381_digestive/alimentary_phenotyp0.68651385
156MP0001533_abnormal_skeleton_physiology0.67022131
157MP0003567_abnormal_fetal_cardiomyocyte0.65941953
158MP0004085_abnormal_heartbeat0.65535290
159MP0002106_abnormal_muscle_physiology0.65435038
160MP0001299_abnormal_eye_distance/0.64508732
161MP0003091_abnormal_cell_migration0.64398111
162MP0009384_cardiac_valve_regurgitation0.64242726
163MP0005595_abnormal_vascular_smooth0.64186336
164MP0002128_abnormal_blood_circulation0.63004324
165MP0005266_abnormal_metabolism0.62418865
166MP0002876_abnormal_thyroid_physiology0.62050434
167MP0003868_abnormal_feces_composition0.58833981
168MP0002925_abnormal_cardiovascular_devel0.58164615

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)5.58108348
2Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.39288455
3Nemaline bodies (HP:0003798)5.38545334
4Exercise-induced myalgia (HP:0003738)5.28782186
5Distal arthrogryposis (HP:0005684)4.67789273
6Thrombocytosis (HP:0001894)4.11482178
7Hyperkalemia (HP:0002153)3.75629695
8Round ear (HP:0100830)3.67480871
9Hyporeflexia of lower limbs (HP:0002600)3.61570110
10Cellulitis (HP:0100658)3.58761879
11Petechiae (HP:0000967)3.51422322
12Prolonged bleeding time (HP:0003010)3.45542187
13Abnormality of the fingertips (HP:0001211)3.41857666
14Aplastic anemia (HP:0001915)3.40036151
15Abnormality of cells of the erythroid lineage (HP:0012130)3.36199344
16Abnormal number of erythroid precursors (HP:0012131)3.34164577
17Muscle hypertrophy of the lower extremities (HP:0008968)3.24754011
18Aortic aneurysm (HP:0004942)3.23736819
19Exercise-induced muscle cramps (HP:0003710)3.17029390
20Calf muscle hypertrophy (HP:0008981)3.13827730
21Acute myeloid leukemia (HP:0004808)3.06700522
22Muscle fiber splitting (HP:0003555)3.06276150
23Myositis (HP:0100614)3.04508503
24Dysmetric saccades (HP:0000641)3.02284222
25Centrally nucleated skeletal muscle fibers (HP:0003687)3.01816091
26Chronic otitis media (HP:0000389)2.97950710
27Abnormality of the calf musculature (HP:0001430)2.94597975
28Increased density of long bones (HP:0006392)2.86192691
29Abnormal platelet function (HP:0011869)2.85462418
30Impaired platelet aggregation (HP:0003540)2.85462418
31EMG: myopathic abnormalities (HP:0003458)2.84899985
32Nasal polyposis (HP:0100582)2.81364843
33Abnormality of skeletal muscle fiber size (HP:0012084)2.76030277
34Increased variability in muscle fiber diameter (HP:0003557)2.75447720
35Bundle branch block (HP:0011710)2.70989813
36Agammaglobulinemia (HP:0004432)2.70317245
37IgM deficiency (HP:0002850)2.68404579
38Frequent falls (HP:0002359)2.66392366
39Verrucae (HP:0200043)2.61722590
40Papilloma (HP:0012740)2.61722590
41Myoglobinuria (HP:0002913)2.61273157
42Abnormality of the nasal mucosa (HP:0000433)2.60219937
43Absent phalangeal crease (HP:0006109)2.53650310
44Acute lymphatic leukemia (HP:0006721)2.51990818
45Reticulocytopenia (HP:0001896)2.51523166
46Hyperacusis (HP:0010780)2.48437710
47Gastrointestinal inflammation (HP:0004386)2.47892920
48Panhypogammaglobulinemia (HP:0003139)2.47415887
49Aortic dissection (HP:0002647)2.46269101
50Neck muscle weakness (HP:0000467)2.44105678
51Rhabdomyolysis (HP:0003201)2.43920654
52Cerebral aneurysm (HP:0004944)2.41736872
53Recurrent viral infections (HP:0004429)2.35918445
54Malignant hyperthermia (HP:0002047)2.35034345
55Colitis (HP:0002583)2.29409023
56Abnormal delayed hypersensitivity skin test (HP:0002963)2.29047369
57Ventricular tachycardia (HP:0004756)2.28213226
58Inflammation of the large intestine (HP:0002037)2.27410165
59Rectal prolapse (HP:0002035)2.26042694
60Hip contracture (HP:0003273)2.25142987
61Difficulty running (HP:0009046)2.24616023
62Mildly elevated creatine phosphokinase (HP:0008180)2.22741513
63Spinal rigidity (HP:0003306)2.22718348
64Ulnar deviation of the wrist (HP:0003049)2.21676422
65Hamartoma of the eye (HP:0010568)2.20387653
66Enlarged penis (HP:0000040)2.18090279
67Spondylolisthesis (HP:0003302)2.15465096
68Obstructive sleep apnea (HP:0002870)2.12164023
69Fetal akinesia sequence (HP:0001989)2.10730677
70Distal lower limb muscle weakness (HP:0009053)2.10577112
71Popliteal pterygium (HP:0009756)2.10394366
72Increased IgE level (HP:0003212)2.09865696
73EMG: neuropathic changes (HP:0003445)2.08019582
74Scapular winging (HP:0003691)2.07148161
75Abnormal finger flexion creases (HP:0006143)2.06704202
76Myopathic facies (HP:0002058)2.06164405
77Sudden death (HP:0001699)2.04974922
78Advanced eruption of teeth (HP:0006288)2.03933839
79Ankle contracture (HP:0006466)2.03668529
80Meningitis (HP:0001287)2.03243820
81Limited hip movement (HP:0008800)2.03133915
82Metatarsus adductus (HP:0001840)2.02983551
83Type 1 muscle fiber predominance (HP:0003803)2.02783006
84Protrusio acetabuli (HP:0003179)2.01999201
85Epistaxis (HP:0000421)2.01260517
86Myelodysplasia (HP:0002863)1.99401068
87Bicuspid aortic valve (HP:0001647)1.99373690
88Pallor (HP:0000980)1.98198299
89Subaortic stenosis (HP:0001682)1.97765401
90Abnormality of the left ventricular outflow tract (HP:0011103)1.97765401
91B lymphocytopenia (HP:0010976)1.97449388
92Abnormality of B cell number (HP:0010975)1.97449388
93Germ cell neoplasia (HP:0100728)1.97361940
94Abnormality of the calcaneus (HP:0008364)1.95702909
95Osteomyelitis (HP:0002754)1.94681254
96Arterial tortuosity (HP:0005116)1.93210529
97High pitched voice (HP:0001620)1.92894976
98Right ventricular cardiomyopathy (HP:0011663)1.92712458
99Fair hair (HP:0002286)1.90200311
100Easy fatigability (HP:0003388)1.89444601
101Bell-shaped thorax (HP:0001591)1.88845154
102Calcaneovalgus deformity (HP:0001848)1.88619169
103Slender build (HP:0001533)1.88566173
104Papilledema (HP:0001085)1.87526602
105Colon cancer (HP:0003003)1.87136735
106Trigonocephaly (HP:0000243)1.86382679
107Hypoplastic ischia (HP:0003175)1.85593297
108Arterial thrombosis (HP:0004420)1.84209476
109Abnormality of the ischium (HP:0003174)1.84023535
110Broad palm (HP:0001169)1.83573676
111Facial diplegia (HP:0001349)1.83016738
112Aortic regurgitation (HP:0001659)1.82883703
113Abnormality of the heme biosynthetic pathway (HP:0010472)1.81948028
114Muscle stiffness (HP:0003552)1.81451866
115Pulmonary fibrosis (HP:0002206)1.81351841
116Abnormal platelet volume (HP:0011876)1.80747602
117Recurrent bacterial skin infections (HP:0005406)1.80663387
118Erythema (HP:0010783)1.80646570
119Hematochezia (HP:0002573)1.80497069
120Abnormality of T cell physiology (HP:0011840)1.80127800
121Thickened calvaria (HP:0002684)1.79695303
122Duplicated collecting system (HP:0000081)1.79550392
123Breech presentation (HP:0001623)1.79487311
124Lip pit (HP:0100267)1.79415948
125Abnormality of lateral ventricle (HP:0030047)1.79221278
126Thyroiditis (HP:0100646)1.78880871
127Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.78734344
128Recurrent fungal infections (HP:0002841)1.78662497
129Vascular tortuosity (HP:0004948)1.77867162
130Male infertility (HP:0003251)1.76804071
131Proximal placement of thumb (HP:0009623)1.76135220
132Pili torti (HP:0003777)1.75777895
133Distal lower limb amyotrophy (HP:0008944)1.75676249
134Recurrent abscess formation (HP:0002722)1.75000903
135Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.74672791
136Spontaneous hematomas (HP:0007420)1.74032579
137Absent/shortened dynein arms (HP:0200106)1.73994033
138Dynein arm defect of respiratory motile cilia (HP:0012255)1.73994033
139Hypochromic anemia (HP:0001931)1.72995415
140Asymmetric septal hypertrophy (HP:0001670)1.72934245
141Chest pain (HP:0100749)1.72775639
142Abnormal atrioventricular conduction (HP:0005150)1.72723078
143Recurrent bronchitis (HP:0002837)1.72703222
144Clumsiness (HP:0002312)1.72270540
145Long eyelashes (HP:0000527)1.70221609
146Poikilocytosis (HP:0004447)1.69720128
147Agnosia (HP:0010524)1.69595136
148Deviation of the thumb (HP:0009603)1.69187866
149Blepharitis (HP:0000498)1.68540235
150Natal tooth (HP:0000695)1.68062769
151Cutaneous melanoma (HP:0012056)1.67764851
152Decreased circulating renin level (HP:0003351)1.67749840
153Conjunctival hamartoma (HP:0100780)1.67077790
154Heart block (HP:0012722)1.66401980
155Increased connective tissue (HP:0009025)1.66014496
156Orchitis (HP:0100796)1.65382667
157Amaurosis fugax (HP:0100576)1.64675443
158Aneurysm (HP:0002617)1.64640057
159Generalized hypopigmentation of hair (HP:0011358)1.64615876
160Slender long bone (HP:0003100)1.64201162
161Bulbar palsy (HP:0001283)1.64069862
162Generalized muscle weakness (HP:0003324)1.63568860
163Deformed tarsal bones (HP:0008119)1.62215210
164Foot dorsiflexor weakness (HP:0009027)1.61439406
165Asymmetry of the thorax (HP:0001555)1.59754543
166Shallow orbits (HP:0000586)1.59172077
167Steppage gait (HP:0003376)1.57893157
168Bladder diverticulum (HP:0000015)1.55318267
169Narrow palate (HP:0000189)1.55097589
170Renovascular hypertension (HP:0100817)1.54337320
171Macroorchidism (HP:0000053)1.54090475
172Muscular dystrophy (HP:0003560)1.51447516
173Heterotopia (HP:0002282)1.49448363
174Hemorrhage of the eye (HP:0011885)1.49313325
175Visceral angiomatosis (HP:0100761)1.48895470
176Coarse hair (HP:0002208)1.48778597
177Ventricular fibrillation (HP:0001663)1.47587521
178Abnormality of potassium homeostasis (HP:0011042)1.47030413
179Gowers sign (HP:0003391)1.46865725

Predicted kinase interactions (KEA)

RankGene SetZ-score
1* EEF2K4.77681728
2OBSCN4.36444498
3TRIB33.53947588
4PKN23.36376357
5MAP3K102.94054908
6CDK122.92684700
7TAOK32.80527490
8MAP3K62.68681978
9ICK2.68269799
10TGFBR22.49738452
11PHKG22.33872234
12PHKG12.33872234
13MAP2K32.23813101
14FLT32.22643712
15KIT2.20738888
16TAOK12.11424990
17SMG12.05000010
18MAP3K131.97537122
19MUSK1.89477483
20AKT31.84253047
21STK101.78273904
22TTN1.73231268
23CSF1R1.70021105
24BTK1.63344502
25WNK41.63224840
26MAP4K11.60029039
27PINK11.58855553
28ERN11.51053651
29RAF11.48225029
30CDK91.47035428
31NEK21.45942483
32LRRK21.43406378
33MATK1.42993160
34* MTOR1.39082369
35STK391.38533540
36NEK91.37742098
37CDC42BPA1.35688056
38MAP3K21.35252434
39FGFR41.31120663
40PRPF4B1.31085761
41WNK11.30115381
42* PRKAA21.29108452
43TGFBR11.24985172
44DMPK1.22214652
45PIM21.15916376
46* MAPKAPK31.12707667
47TEC1.11924873
48PDPK11.11017058
49SCYL21.10132122
50DDR21.08443775
51RPS6KA41.07939746
52DYRK31.03981944
53PAK41.03442932
54MARK21.03187172
55CDK41.03128378
56SYK1.02430855
57ILK1.00236856
58FES0.98773602
59* TRPM70.98760365
60* MAPK120.98479195
61SIK10.98416073
62PTK60.97513374
63KSR20.97508347
64PAK20.97418985
65PIK3CG0.97091413
66* PRKAA10.97044626
67JAK30.96466154
68TTK0.95866918
69* RPS6KB20.94133067
70FER0.92856959
71PIM10.91373246
72RET0.90135211
73MELK0.89532950
74CDC70.86438452
75ZAP700.86412638
76CDK80.86239344
77MAP3K70.85638892
78TNK20.85093031
79* MAPK110.84975261
80CDK60.84675269
81RIPK10.84146568
82LATS10.81211832
83CDK30.80878056
84CAMK1G0.79720400
85AKT20.79600830
86MET0.79315438
87TYK20.78911765
88NME10.78791570
89LATS20.78095423
90VRK10.77855219
91CAMK1D0.77435040
92MAP3K80.76929189
93TBK10.75970539
94PDK10.75583860
95MAP2K10.75479318
96MAPK150.74687050
97HCK0.74130902
98SIK20.72437330
99CAMK40.71308772
100CDK190.69454340
101BMPR1B0.69183148
102STK40.68799155
103SGK30.66636161
104MAP3K30.66583055
105MAPK40.66270143
106EIF2AK30.66130828
107HIPK20.64302255
108FGFR30.61541704
109* MAPKAPK20.60528079
110MST1R0.58486346
111SGK20.57992005
112AURKB0.55323412
113RPS6KA60.54105138
114CCNB10.53709533
115LYN0.53382106
116MAP2K40.53365246
117NLK0.51738109
118ITK0.51111280
119MAPK100.50447629
120GRK60.50059134
121MAPK70.49682439
122SGK10.49015564
123JAK20.47847980
124ROCK10.46909352
125* RPS6KB10.46830791
126PIK3CA0.46313344
127MYLK0.45730707
128DAPK10.44399023
129ACVR1B0.43929348
130NME20.43564024
131MAP2K60.43497015
132JAK10.43464434
133STK30.43237178
134RPS6KL10.43100673
135RPS6KC10.43100673
136BRD40.41962924
137NTRK30.41790597
138CDK70.41278150
139STK240.40744745
140TLK10.40617652
141IRAK30.39727076
142PRKD30.39341632
143SGK4940.39019731
144SGK2230.39019731
145NEK60.38163920
146CAMK10.36660434
147GSK3B0.36569161
148TSSK60.36526970
149LCK0.35958516
150MOS0.35488459
151PDGFRA0.35236806
152PDGFRB0.34056609
153ATR0.33927490
154PRKD20.33876897
155FRK0.33234103
156* MAPK80.32094501
157* RPS6KA30.31856154
158MAPK10.31132158
159LMTK20.30864983
160MAPK30.30596894
161TIE10.29429414

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.35620884
2Lysine degradation_Homo sapiens_hsa003102.11127326
3Chronic myeloid leukemia_Homo sapiens_hsa052202.08732008
4DNA replication_Homo sapiens_hsa030302.04654153
5Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.99240758
6Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.88682105
7B cell receptor signaling pathway_Homo sapiens_hsa046621.87297732
8Other glycan degradation_Homo sapiens_hsa005111.86365130
9Dilated cardiomyopathy_Homo sapiens_hsa054141.83221692
10Ribosome_Homo sapiens_hsa030101.80123155
11Pancreatic cancer_Homo sapiens_hsa052121.75577168
12Platelet activation_Homo sapiens_hsa046111.73336593
13Cell cycle_Homo sapiens_hsa041101.71001043
14Acute myeloid leukemia_Homo sapiens_hsa052211.66868968
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.62738900
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.59843528
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.58840855
18Transcriptional misregulation in cancer_Homo sapiens_hsa052021.58240077
19Glucagon signaling pathway_Homo sapiens_hsa049221.50641471
20Colorectal cancer_Homo sapiens_hsa052101.50550295
21Non-small cell lung cancer_Homo sapiens_hsa052231.50496313
22Mismatch repair_Homo sapiens_hsa034301.49226350
23Base excision repair_Homo sapiens_hsa034101.48105326
24ABC transporters_Homo sapiens_hsa020101.46484308
25Arginine biosynthesis_Homo sapiens_hsa002201.44041717
26Osteoclast differentiation_Homo sapiens_hsa043801.40765090
27Primary immunodeficiency_Homo sapiens_hsa053401.40463046
28Adipocytokine signaling pathway_Homo sapiens_hsa049201.38887452
29Dorso-ventral axis formation_Homo sapiens_hsa043201.38144864
30Vascular smooth muscle contraction_Homo sapiens_hsa042701.34625686
31Histidine metabolism_Homo sapiens_hsa003401.31790131
32Non-homologous end-joining_Homo sapiens_hsa034501.29765556
33Prolactin signaling pathway_Homo sapiens_hsa049171.28590394
34* AMPK signaling pathway_Homo sapiens_hsa041521.27660990
35Hepatitis B_Homo sapiens_hsa051611.26133173
36Small cell lung cancer_Homo sapiens_hsa052221.25887251
37ECM-receptor interaction_Homo sapiens_hsa045121.25277226
38VEGF signaling pathway_Homo sapiens_hsa043701.24587728
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.22716514
40Fatty acid biosynthesis_Homo sapiens_hsa000611.22349008
41Toxoplasmosis_Homo sapiens_hsa051451.21614317
42Choline metabolism in cancer_Homo sapiens_hsa052311.20666007
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.20576948
44Hematopoietic cell lineage_Homo sapiens_hsa046401.20203455
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.19125524
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.18442125
47Jak-STAT signaling pathway_Homo sapiens_hsa046301.17022610
48Neurotrophin signaling pathway_Homo sapiens_hsa047221.16199219
49RNA degradation_Homo sapiens_hsa030181.15135482
50Leishmaniasis_Homo sapiens_hsa051401.14564494
51Fructose and mannose metabolism_Homo sapiens_hsa000511.13527877
52* Oxytocin signaling pathway_Homo sapiens_hsa049211.13328713
53Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.11769671
54PPAR signaling pathway_Homo sapiens_hsa033201.11194623
55Phenylalanine metabolism_Homo sapiens_hsa003601.10146272
56Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.09365172
57Notch signaling pathway_Homo sapiens_hsa043301.08494688
58p53 signaling pathway_Homo sapiens_hsa041151.03421845
59Ovarian steroidogenesis_Homo sapiens_hsa049131.03135643
60Glioma_Homo sapiens_hsa052141.03122921
61Endometrial cancer_Homo sapiens_hsa052131.02418153
62Glycosaminoglycan degradation_Homo sapiens_hsa005311.02379544
63Calcium signaling pathway_Homo sapiens_hsa040201.01774369
64N-Glycan biosynthesis_Homo sapiens_hsa005101.01683754
65Aldosterone synthesis and secretion_Homo sapiens_hsa049251.01544268
66MicroRNAs in cancer_Homo sapiens_hsa052061.01368938
672-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.01049291
68Apoptosis_Homo sapiens_hsa042101.00561684
69Fatty acid degradation_Homo sapiens_hsa000710.97588348
70Measles_Homo sapiens_hsa051620.97136768
71Herpes simplex infection_Homo sapiens_hsa051680.96496745
72Thyroid cancer_Homo sapiens_hsa052160.96495674
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.93365519
74GnRH signaling pathway_Homo sapiens_hsa049120.92731941
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.91610429
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.91599912
77Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.90852922
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.90756213
79Vitamin digestion and absorption_Homo sapiens_hsa049770.90459364
80Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.88625402
81Tight junction_Homo sapiens_hsa045300.87861545
82Influenza A_Homo sapiens_hsa051640.87422383
83HTLV-I infection_Homo sapiens_hsa051660.85968410
84Arginine and proline metabolism_Homo sapiens_hsa003300.85382737
85FoxO signaling pathway_Homo sapiens_hsa040680.85289845
86Toll-like receptor signaling pathway_Homo sapiens_hsa046200.85177625
87Selenocompound metabolism_Homo sapiens_hsa004500.84401055
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84282371
89ErbB signaling pathway_Homo sapiens_hsa040120.84072758
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.82676148
91Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.82069989
92Shigellosis_Homo sapiens_hsa051310.81763436
93Renal cell carcinoma_Homo sapiens_hsa052110.81551416
94Prostate cancer_Homo sapiens_hsa052150.81389724
95Insulin resistance_Homo sapiens_hsa049310.80596680
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.80446556
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80252773
98Linoleic acid metabolism_Homo sapiens_hsa005910.79861664
99Circadian rhythm_Homo sapiens_hsa047100.79586525
100Viral carcinogenesis_Homo sapiens_hsa052030.79359100
101Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79191423
102Nitrogen metabolism_Homo sapiens_hsa009100.78091444
103Inositol phosphate metabolism_Homo sapiens_hsa005620.77976828
104mTOR signaling pathway_Homo sapiens_hsa041500.77972324
105Gastric acid secretion_Homo sapiens_hsa049710.77952268
106Antigen processing and presentation_Homo sapiens_hsa046120.77044142
107Fatty acid metabolism_Homo sapiens_hsa012120.76821227
108Long-term potentiation_Homo sapiens_hsa047200.76274317
109Focal adhesion_Homo sapiens_hsa045100.73590676
110Renin secretion_Homo sapiens_hsa049240.73473090
111Bladder cancer_Homo sapiens_hsa052190.71605241
112Insulin signaling pathway_Homo sapiens_hsa049100.70507263
113Systemic lupus erythematosus_Homo sapiens_hsa053220.70418356
114Olfactory transduction_Homo sapiens_hsa047400.70413535
115Salivary secretion_Homo sapiens_hsa049700.69960015
116Type II diabetes mellitus_Homo sapiens_hsa049300.69834769
117Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69598428
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.69583631
119HIF-1 signaling pathway_Homo sapiens_hsa040660.68735451
120Bile secretion_Homo sapiens_hsa049760.68370675
121Cyanoamino acid metabolism_Homo sapiens_hsa004600.67755234
122Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67270221
123Ether lipid metabolism_Homo sapiens_hsa005650.66358081
124Estrogen signaling pathway_Homo sapiens_hsa049150.66213718
125Long-term depression_Homo sapiens_hsa047300.65165558
126Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64551177
127Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64216614
128Chemokine signaling pathway_Homo sapiens_hsa040620.62876007
129Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61890923
130Pathways in cancer_Homo sapiens_hsa052000.61242694
131TNF signaling pathway_Homo sapiens_hsa046680.61029441
132Tyrosine metabolism_Homo sapiens_hsa003500.61029123
133Pentose phosphate pathway_Homo sapiens_hsa000300.60801629
134cAMP signaling pathway_Homo sapiens_hsa040240.59617495
135Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.58728023
136Caffeine metabolism_Homo sapiens_hsa002320.58089610
137Homologous recombination_Homo sapiens_hsa034400.56864852
138Amoebiasis_Homo sapiens_hsa051460.55559303
139Spliceosome_Homo sapiens_hsa030400.55481839
140Protein digestion and absorption_Homo sapiens_hsa049740.55401173
141Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55358592
142Pertussis_Homo sapiens_hsa051330.54986995
143Glycerolipid metabolism_Homo sapiens_hsa005610.54825849
144Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53339026
145Phospholipase D signaling pathway_Homo sapiens_hsa040720.53330369
146Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53055343
147Viral myocarditis_Homo sapiens_hsa054160.52635812
148Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52549762
149Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52438811
150Sphingolipid metabolism_Homo sapiens_hsa006000.52247588
151Thyroid hormone synthesis_Homo sapiens_hsa049180.52204201
152Proteoglycans in cancer_Homo sapiens_hsa052050.51854020
153Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51343850
154Renin-angiotensin system_Homo sapiens_hsa046140.51279738
155Fanconi anemia pathway_Homo sapiens_hsa034600.50035170
156Adherens junction_Homo sapiens_hsa045200.49822765
157Nucleotide excision repair_Homo sapiens_hsa034200.49155973
158MAPK signaling pathway_Homo sapiens_hsa040100.48752761
159Tuberculosis_Homo sapiens_hsa051520.48729416
160NF-kappa B signaling pathway_Homo sapiens_hsa040640.48330833

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