EEF1GP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.12634471
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.96488226
3cytidine deamination (GO:0009972)5.80943657
4cytidine metabolic process (GO:0046087)5.80943657
5cytidine catabolic process (GO:0006216)5.80943657
6pyrimidine ribonucleoside catabolic process (GO:0046133)4.92619025
7Arp2/3 complex-mediated actin nucleation (GO:0034314)4.91527327
8actin nucleation (GO:0045010)4.54434453
9ncRNA 3-end processing (GO:0043628)4.37582864
10positive thymic T cell selection (GO:0045059)4.30232705
11ribosomal small subunit assembly (GO:0000028)4.09172653
12positive T cell selection (GO:0043368)3.77471711
13mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.76898192
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.76165451
15ribosomal small subunit biogenesis (GO:0042274)3.65833479
16regulation of gamma-delta T cell differentiation (GO:0045586)3.58535957
17regulation of regulatory T cell differentiation (GO:0045589)3.54875047
18positive regulation of gamma-delta T cell activation (GO:0046645)3.40812844
19ATP synthesis coupled proton transport (GO:0015986)3.39785375
20energy coupled proton transport, down electrochemical gradient (GO:0015985)3.39785375
21mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.33897036
22NADH metabolic process (GO:0006734)3.32313407
23response to interferon-beta (GO:0035456)3.28083430
24regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.24133121
25positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.23920566
26positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.23287636
27positive regulation of natural killer cell mediated immunity (GO:0002717)3.23124688
28positive regulation of T cell mediated cytotoxicity (GO:0001916)3.14479128
29positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.13631080
30regulation of leukocyte mediated cytotoxicity (GO:0001910)3.11302399
31water-soluble vitamin biosynthetic process (GO:0042364)3.05534934
32immunoglobulin mediated immune response (GO:0016064)3.02574066
33regulation of T cell mediated cytotoxicity (GO:0001914)3.00020401
34respiratory electron transport chain (GO:0022904)2.99309340
35regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.98879938
36regulation of natural killer cell mediated immunity (GO:0002715)2.98879938
37deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.97557307
38T cell migration (GO:0072678)2.97104732
39electron transport chain (GO:0022900)2.97071770
40negative T cell selection (GO:0043383)2.96311676
41mast cell degranulation (GO:0043303)2.92973849
42mast cell activation involved in immune response (GO:0002279)2.92973849
43regulation of gamma-delta T cell activation (GO:0046643)2.92867589
44fucose catabolic process (GO:0019317)2.91955389
45L-fucose metabolic process (GO:0042354)2.91955389
46L-fucose catabolic process (GO:0042355)2.91955389
47T cell receptor signaling pathway (GO:0050852)2.91710138
48T cell costimulation (GO:0031295)2.91218414
49regulation of cellular amino acid metabolic process (GO:0006521)2.89199109
50lymphocyte costimulation (GO:0031294)2.88057765
51negative regulation of T cell apoptotic process (GO:0070233)2.87739386
52tryptophan metabolic process (GO:0006568)2.87653868
53behavioral response to nicotine (GO:0035095)2.87631124
54negative regulation of phagocytosis (GO:0050765)2.87031201
55indole-containing compound catabolic process (GO:0042436)2.86840166
56indolalkylamine catabolic process (GO:0046218)2.86840166
57tryptophan catabolic process (GO:0006569)2.86840166
58thymic T cell selection (GO:0045061)2.86826695
59piRNA metabolic process (GO:0034587)2.85408924
60positive regulation of cell killing (GO:0031343)2.84101235
61sulfation (GO:0051923)2.82382360
62negative regulation of viral genome replication (GO:0045071)2.80240522
63regulation of cell killing (GO:0031341)2.78074917
64RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.78023307
65tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.78023307
66response to pheromone (GO:0019236)2.76793648
67positive regulation of defense response to virus by host (GO:0002230)2.75541872
68positive regulation of B cell differentiation (GO:0045579)2.72946490
69cellular response to interleukin-15 (GO:0071350)2.72304679
70mast cell activation (GO:0045576)2.68631431
71protein neddylation (GO:0045116)2.66866989
72positive regulation of interleukin-8 secretion (GO:2000484)2.65989328
73adaptation of signaling pathway (GO:0023058)2.65865598
74positive regulation of calcium-mediated signaling (GO:0050850)2.65713169
75protein import into peroxisome matrix (GO:0016558)2.64603358
76regulation of activation of Janus kinase activity (GO:0010533)2.64315936
77pyrimidine nucleoside catabolic process (GO:0046135)2.64297467
78detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.61855914
79sequestering of actin monomers (GO:0042989)2.59497039
80indolalkylamine metabolic process (GO:0006586)2.59491419
81detection of light stimulus involved in visual perception (GO:0050908)2.58948628
82detection of light stimulus involved in sensory perception (GO:0050962)2.58948628
83organelle membrane fusion (GO:0090174)2.58285068
84negative thymic T cell selection (GO:0045060)2.58051270
85regulation of alpha-beta T cell proliferation (GO:0046640)2.57149399
86antigen receptor-mediated signaling pathway (GO:0050851)2.56915669
87cellular response to interferon-beta (GO:0035458)2.54642089
88regulation of interleukin-8 secretion (GO:2000482)2.54338014
89rRNA modification (GO:0000154)2.53906697
90positive regulation of alpha-beta T cell proliferation (GO:0046641)2.53152485
91antigen processing and presentation of endogenous antigen (GO:0019883)2.52107339
92antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.52010034
93DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.51756112
94adenosine metabolic process (GO:0046085)2.48813211
95positive regulation of chemokine secretion (GO:0090197)2.47175307
96nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.46191090
97cytolysis (GO:0019835)2.46009881
98purine-containing compound salvage (GO:0043101)2.41089382
99autophagic vacuole fusion (GO:0000046)2.40955168
100regulation of B cell receptor signaling pathway (GO:0050855)2.40727654

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.95035001
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.76918634
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.67623149
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.20472015
5VDR_22108803_ChIP-Seq_LS180_Human3.02075189
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.82724882
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.82469842
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.76297264
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.68425877
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.66500638
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.53149728
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.39077052
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.23580472
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.16993807
15IGF1R_20145208_ChIP-Seq_DFB_Human2.04554988
16ZNF274_21170338_ChIP-Seq_K562_Hela2.02369935
17LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.99390147
18MYB_26560356_Chip-Seq_TH2_Human1.97739168
19IRF8_21731497_ChIP-ChIP_J774_Mouse1.76916163
20VDR_23849224_ChIP-Seq_CD4+_Human1.75551366
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.72214602
22RUNX_20019798_ChIP-Seq_JUKART_Human1.65037938
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.58901073
24EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.58058038
25PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.56239350
26GATA3_26560356_Chip-Seq_TH2_Human1.55488344
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.54600465
28FOXA1_25329375_ChIP-Seq_VCAP_Human1.54325479
29FOXA1_27270436_Chip-Seq_PROSTATE_Human1.54325479
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.52084059
31NANOG_20526341_ChIP-Seq_ESCs_Human1.51105248
32EZH2_22144423_ChIP-Seq_EOC_Human1.45920914
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.45459057
34AR_20517297_ChIP-Seq_VCAP_Human1.44792816
35BCL6_27268052_Chip-Seq_Bcells_Human1.44761909
36RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.44757295
37NCOR_22424771_ChIP-Seq_293T_Human1.42784248
38GATA3_27048872_Chip-Seq_THYMUS_Human1.42485746
39TP53_22573176_ChIP-Seq_HFKS_Human1.41318748
40TAF2_19829295_ChIP-Seq_ESCs_Human1.40907517
41SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.40725399
42STAT4_19710469_ChIP-ChIP_TH1__Mouse1.40666275
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.36506206
44AUTS2_25519132_ChIP-Seq_293T-REX_Human1.34721042
45PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.34075820
46FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.32647694
47GATA3_21878914_ChIP-Seq_MCF-7_Human1.30415008
48ERA_21632823_ChIP-Seq_H3396_Human1.28941928
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.28177435
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27654747
51FOXA1_21572438_ChIP-Seq_LNCaP_Human1.27245025
52EGR1_23403033_ChIP-Seq_LIVER_Mouse1.27236627
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26229655
54ERG_20517297_ChIP-Seq_VCAP_Human1.25559016
55SRF_21415370_ChIP-Seq_HL-1_Mouse1.23388460
56MYC_19829295_ChIP-Seq_ESCs_Human1.21040496
57TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.20852715
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18823716
59CBP_20019798_ChIP-Seq_JUKART_Human1.18823716
60FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.18038072
61FOXH1_21741376_ChIP-Seq_EPCs_Human1.15682838
62CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.14723664
63YY1_21170310_ChIP-Seq_MESCs_Mouse1.14189947
64FOXP3_21729870_ChIP-Seq_TREG_Human1.13722874
65VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.12951617
66NANOG_19829295_ChIP-Seq_ESCs_Human1.12676243
67SOX2_19829295_ChIP-Seq_ESCs_Human1.12676243
68FUS_26573619_Chip-Seq_HEK293_Human1.10264986
69P300_27268052_Chip-Seq_Bcells_Human1.09745480
70PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.09456429
71EWS_26573619_Chip-Seq_HEK293_Human1.08184167
72LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06257809
73PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06206106
74GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.05523879
75ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05073901
76CTBP1_25329375_ChIP-Seq_LNCAP_Human1.04423015
77NOTCH1_21737748_ChIP-Seq_TLL_Human1.04402156
78FOXH1_21741376_ChIP-Seq_ESCs_Human1.03850723
79SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.02289591
80GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.01607813
81EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.01174226
82TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00765896
83MYB_26560356_Chip-Seq_TH1_Human1.00409240
84ER_23166858_ChIP-Seq_MCF-7_Human0.99216186
85GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.99059449
86OCT4_20526341_ChIP-Seq_ESCs_Human0.98656975
87SPI1_23547873_ChIP-Seq_NB4_Human0.97890014
88HTT_18923047_ChIP-ChIP_STHdh_Human0.97784670
89RAC3_21632823_ChIP-Seq_H3396_Human0.97702576
90YY1_22570637_ChIP-Seq_MALME-3M_Human0.97601118
91NFE2_27457419_Chip-Seq_LIVER_Mouse0.97459783
92STAT1_20625510_ChIP-Seq_HELA_Human0.96157681
93CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.96000681
94TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95622566
95IRF1_19129219_ChIP-ChIP_H3396_Human0.95476685
96HOXB7_26014856_ChIP-Seq_BT474_Human0.94936423
97BCAT_22108803_ChIP-Seq_LS180_Human0.93597228
98GATA6_21074721_ChIP-Seq_CACO-2_Human0.93429716
99E2F1_20622854_ChIP-Seq_HELA_Human0.92119551
100GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92087046

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.86610362
2MP0001873_stomach_inflammation2.90287437
3MP0009785_altered_susceptibility_to2.89174126
4MP0006082_CNS_inflammation2.72378349
5MP0001835_abnormal_antigen_presentation2.70673942
6MP0005645_abnormal_hypothalamus_physiol2.32916398
7MP0003763_abnormal_thymus_physiology2.25744143
8MP0001800_abnormal_humoral_immune2.24143759
9MP0008875_abnormal_xenobiotic_pharmacok2.16503905
10MP0004510_myositis2.08372041
11MP0005410_abnormal_fertilization2.03930063
12MP0003646_muscle_fatigue2.02516808
13MP0005000_abnormal_immune_tolerance1.99698262
14MP0002166_altered_tumor_susceptibility1.92147626
15MP0002138_abnormal_hepatobiliary_system1.89316214
16MP0002420_abnormal_adaptive_immunity1.88975346
17MP0002723_abnormal_immune_serum1.87015550
18MP0001819_abnormal_immune_cell1.84789814
19MP0002148_abnormal_hypersensitivity_rea1.83940443
20MP0005025_abnormal_response_to1.80541522
21MP0003195_calcinosis1.80379123
22MP0010155_abnormal_intestine_physiology1.79305299
23MP0008872_abnormal_physiological_respon1.78165513
24MP0005075_abnormal_melanosome_morpholog1.75933047
25MP0009379_abnormal_foot_pigmentation1.75584702
26MP0009333_abnormal_splenocyte_physiolog1.75047425
27MP0002933_joint_inflammation1.74204549
28MP0002452_abnormal_antigen_presenting1.73860189
29MP0008877_abnormal_DNA_methylation1.72614050
30MP0003879_abnormal_hair_cell1.66150385
31MP0005377_hearing/vestibular/ear_phenot1.61210375
32MP0003878_abnormal_ear_physiology1.61210375
33MP0005646_abnormal_pituitary_gland1.58649847
34MP0005551_abnormal_eye_electrophysiolog1.55134643
35MP0000372_irregular_coat_pigmentation1.53588562
36MP0002006_tumorigenesis1.47536008
37MP0005360_urolithiasis1.45998931
38MP0003866_abnormal_defecation1.45857611
39MP0001845_abnormal_inflammatory_respons1.44282964
40MP0000716_abnormal_immune_system1.44259437
41MP0001905_abnormal_dopamine_level1.43339781
42MP0002419_abnormal_innate_immunity1.40157925
43MP0001986_abnormal_taste_sensitivity1.39598221
44MP0003724_increased_susceptibility_to1.38962859
45MP0006072_abnormal_retinal_apoptosis1.38918771
46MP0001968_abnormal_touch/_nociception1.37774830
47MP0005389_reproductive_system_phenotype1.37134673
48MP0001790_abnormal_immune_system1.36322039
49MP0005387_immune_system_phenotype1.36322039
50MP0009764_decreased_sensitivity_to1.35076334
51MP0002405_respiratory_system_inflammati1.33284589
52MP0002398_abnormal_bone_marrow1.32289501
53MP0004145_abnormal_muscle_electrophysio1.31549325
54MP0000689_abnormal_spleen_morphology1.28548091
55MP0001919_abnormal_reproductive_system1.28331519
56MP0003011_delayed_dark_adaptation1.25185902
57MP0008995_early_reproductive_senescence1.21623614
58MP0000685_abnormal_immune_system1.19182795
59MP0002722_abnormal_immune_system1.17856870
60MP0004147_increased_porphyrin_level1.17838275
61MP0002102_abnormal_ear_morphology1.17815849
62MP0002837_dystrophic_cardiac_calcinosis1.17527998
63MP0000703_abnormal_thymus_morphology1.14447147
64MP0001765_abnormal_ion_homeostasis1.13115708
65MP0002876_abnormal_thyroid_physiology1.10157564
66MP0002429_abnormal_blood_cell1.09350011
67MP0008469_abnormal_protein_level1.06020716
68MP0004947_skin_inflammation1.04961057
69MP0003436_decreased_susceptibility_to1.01939455
70MP0004885_abnormal_endolymph0.99617160
71MP0002160_abnormal_reproductive_system0.98371021
72MP0005084_abnormal_gallbladder_morpholo0.98126192
73MP0001663_abnormal_digestive_system0.97824457
74MP0005636_abnormal_mineral_homeostasis0.96316160
75MP0002736_abnormal_nociception_after0.95201022
76MP0003252_abnormal_bile_duct0.93852164
77MP0001984_abnormal_olfaction0.93235088
78MP0005253_abnormal_eye_physiology0.91621539
79MP0005174_abnormal_tail_pigmentation0.87731766
80MP0003806_abnormal_nucleotide_metabolis0.86272671
81MP0001533_abnormal_skeleton_physiology0.85908100
82MP0001485_abnormal_pinna_reflex0.84887875
83MP0000013_abnormal_adipose_tissue0.84525725
84MP0002638_abnormal_pupillary_reflex0.83631326
85MP0001727_abnormal_embryo_implantation0.82899573
86MP0005085_abnormal_gallbladder_physiolo0.81898038
87MP0009643_abnormal_urine_homeostasis0.81414158
88MP0006276_abnormal_autonomic_nervous0.79532048
89MP0002277_abnormal_respiratory_mucosa0.77877162
90MP0009763_increased_sensitivity_to0.75880118
91MP0002693_abnormal_pancreas_physiology0.74466200
92MP0000230_abnormal_systemic_arterial0.73490936
93MP0001929_abnormal_gametogenesis0.72292939
94MP0002272_abnormal_nervous_system0.71695009
95MP0002095_abnormal_skin_pigmentation0.71664318
96MP0003786_premature_aging0.70669534
97MP0003183_abnormal_peptide_metabolism0.70079544
98MP0005167_abnormal_blood-brain_barrier0.69741725
99MP0005166_decreased_susceptibility_to0.69397015
100MP0003718_maternal_effect0.69343500

Predicted human phenotypes

RankGene SetZ-score
1Attenuation of retinal blood vessels (HP:0007843)4.70463482
2Elevated erythrocyte sedimentation rate (HP:0003565)4.57506527
3Constricted visual fields (HP:0001133)4.03859360
4Decreased electroretinogram (ERG) amplitude (HP:0000654)3.98743347
5Absent rod-and cone-mediated responses on ERG (HP:0007688)3.91232796
6IgG deficiency (HP:0004315)3.85318687
7T lymphocytopenia (HP:0005403)3.70532444
8Decreased central vision (HP:0007663)3.57450055
9Severe combined immunodeficiency (HP:0004430)3.52756705
10Abnormality of T cell number (HP:0011839)3.41839725
11Abnormality of macular pigmentation (HP:0008002)3.39452912
12Striae distensae (HP:0001065)3.24293905
13Cone-rod dystrophy (HP:0000548)3.18595764
14Abnormality of B cell number (HP:0010975)3.18089059
15Thyroiditis (HP:0100646)3.03266533
16Abnormal rod and cone electroretinograms (HP:0008323)3.01420977
17Mitochondrial inheritance (HP:0001427)2.97147555
18Abolished electroretinogram (ERG) (HP:0000550)2.93910964
19B lymphocytopenia (HP:0010976)2.85148108
20Hepatocellular necrosis (HP:0001404)2.82197757
21Acute necrotizing encephalopathy (HP:0006965)2.76939714
22Abnormality of T cells (HP:0002843)2.72163367
23Abnormal mitochondria in muscle tissue (HP:0008316)2.71004793
24Optic disc pallor (HP:0000543)2.70542048
25Combined immunodeficiency (HP:0005387)2.68621343
26Congenital stationary night blindness (HP:0007642)2.67883116
27Abnormality of the prostate (HP:0008775)2.66019739
28Pendular nystagmus (HP:0012043)2.65689315
29Autoimmune hemolytic anemia (HP:0001890)2.65631280
30Hepatic necrosis (HP:0002605)2.62490294
31Round ear (HP:0100830)2.62112001
32Chronic diarrhea (HP:0002028)2.61093760
33IgM deficiency (HP:0002850)2.59627435
34Hypoproteinemia (HP:0003075)2.58064942
35Aplastic anemia (HP:0001915)2.57390542
36Increased CSF lactate (HP:0002490)2.51874070
37Progressive macrocephaly (HP:0004481)2.44750453
38Dynein arm defect of respiratory motile cilia (HP:0012255)2.44245544
39Absent/shortened dynein arms (HP:0200106)2.44245544
40Aplasia/Hypoplasia of the spleen (HP:0010451)2.39812842
41Increased intramyocellular lipid droplets (HP:0012240)2.39141348
42Hypoalbuminemia (HP:0003073)2.35189970
43Abnormal albumin level (HP:0012116)2.35189970
44Type 2 muscle fiber atrophy (HP:0003554)2.33541341
45Acute encephalopathy (HP:0006846)2.33124040
46Asplenia (HP:0001746)2.31986470
47Abnormality of eosinophils (HP:0001879)2.30738401
48Increased hepatocellular lipid droplets (HP:0006565)2.30154022
49Keratoconus (HP:0000563)2.29708162
50Increased corneal curvature (HP:0100692)2.29708162
51Renal Fanconi syndrome (HP:0001994)2.27332435
52Cerebral edema (HP:0002181)2.21602584
53Recurrent bronchitis (HP:0002837)2.20194795
54Pancreatic fibrosis (HP:0100732)2.16922573
55Toxemia of pregnancy (HP:0100603)2.15799324
56Encephalitis (HP:0002383)2.13711013
57Panhypogammaglobulinemia (HP:0003139)2.12743006
58Hypoplasia of the uterus (HP:0000013)2.11795612
59Myositis (HP:0100614)2.09915822
60Lipid accumulation in hepatocytes (HP:0006561)2.08458196
61Abnormality of fatty-acid metabolism (HP:0004359)2.06100116
62Cupped ribs (HP:0000887)2.05508686
63Stomatitis (HP:0010280)2.03750054
64Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.03586159
65Pancreatic cysts (HP:0001737)2.01321543
66Volvulus (HP:0002580)1.99495602
67Muscle fiber atrophy (HP:0100295)1.98261610
68Congenital, generalized hypertrichosis (HP:0004540)1.97698864
69Polydipsia (HP:0001959)1.97429162
70Abnormal drinking behavior (HP:0030082)1.97429162
71Recurrent sinusitis (HP:0011108)1.97362359
72Increased muscle lipid content (HP:0009058)1.96996262
73Abnormality of T cell physiology (HP:0011840)1.95941752
74Retrobulbar optic neuritis (HP:0100654)1.95791481
75Optic neuritis (HP:0100653)1.95791481
76Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.93724637
77Abnormality of urine glucose concentration (HP:0011016)1.93381451
78Glycosuria (HP:0003076)1.93381451
79Ketosis (HP:0001946)1.93042127
80Recurrent otitis media (HP:0000403)1.89601252
81Chronic mucocutaneous candidiasis (HP:0002728)1.89510872
82Recurrent cutaneous fungal infections (HP:0011370)1.89510872
83Vasculitis (HP:0002633)1.89079432
84Agammaglobulinemia (HP:0004432)1.87184164
85Cerebral palsy (HP:0100021)1.86628476
86Leukocytosis (HP:0001974)1.86469349
87Hypothermia (HP:0002045)1.85468556
88Alkalosis (HP:0001948)1.84978732
89Aplasia/hypoplasia of the uterus (HP:0008684)1.84297688
90Type I transferrin isoform profile (HP:0003642)1.82382451
91True hermaphroditism (HP:0010459)1.81873672
92Hyperglycinemia (HP:0002154)1.81754353
93Lethargy (HP:0001254)1.80313896
94Hemiplegia (HP:0002301)1.80173083
95Emotional lability (HP:0000712)1.79484829
96Lactic acidosis (HP:0003128)1.78651112
97Exertional dyspnea (HP:0002875)1.78443892
98Eosinophilia (HP:0001880)1.78370078
99Bronchitis (HP:0012387)1.77097826
100Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.75983709

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK23.96362877
2KIT3.95939331
3KDR3.57928886
4TXK3.55886359
5TLK13.52613240
6BCKDK3.34564272
7TAOK32.85930434
8ZAK2.67969489
9FES2.55028768
10FRK2.53076189
11TEC2.48283372
12MAP4K12.47188168
13MAP4K22.30011556
14SCYL22.12995261
15TIE12.08891613
16ADRBK22.05970134
17SYK1.78133492
18ITK1.73817522
19GRK11.65100460
20STK161.64946802
21VRK21.61375004
22GRK61.59268382
23IKBKE1.48942005
24VRK11.41583886
25INSRR1.39359433
26IKBKB1.37257293
27TESK11.35450019
28PLK41.30961194
29NUAK11.25972984
30CSF1R1.25117114
31BTK1.22237268
32MST41.22151588
33WNK41.20376460
34EIF2AK31.17824938
35CSK1.16966006
36BMPR1B1.13379949
37LIMK11.10330818
38LCK1.07775586
39PRKCQ1.07440449
40TNK21.06993019
41TBK10.99306928
42LYN0.92943419
43ACVR1B0.89629766
44PLK20.83197610
45PIK3CG0.82602405
46RPS6KA50.79534252
47PHKG10.74207667
48PHKG20.74207667
49ZAP700.74006056
50ADRBK10.73717302
51STK390.72453803
52PASK0.69272611
53WNK30.67621387
54PINK10.63999970
55TYRO30.60773312
56NME20.57487263
57JAK30.56280957
58MAPKAPK50.56205595
59OBSCN0.53623918
60OXSR10.53317401
61GRK70.52710480
62PRKCA0.50081059
63MYLK0.46181233
64DAPK10.45906409
65CSNK1G30.44380663
66INSR0.44230735
67PRKACA0.42141220
68PIM20.42091751
69EGFR0.41937653
70IGF1R0.40709191
71FYN0.39899945
72CDK190.38356920
73ERBB30.38235556
74PRKCG0.37346014
75BMPR20.37261000
76GRK50.36047538
77PRKCI0.35614264
78RIPK40.34868225
79ABL10.34593859
80HCK0.33845960
81SRC0.33384654
82MAPK110.32913351
83MUSK0.32023907
84ABL20.31849198
85MATK0.31777890
86MAPKAPK30.31749710
87ARAF0.31417058
88CSNK1G10.31046610
89FLT30.30182234
90PRKCB0.28716215
91PIM10.27515437
92MAP2K60.27262732
93FGFR20.26491925
94MAPK130.26389793
95MAP3K140.26008589
96MAP3K120.25322030
97MKNK10.25240992
98CSNK1A10.24430881
99PRKCD0.23825380
100CSNK2A10.23439741

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.25730229
2Graft-versus-host disease_Homo sapiens_hsa053323.32702938
3Proteasome_Homo sapiens_hsa030503.29986008
4Allograft rejection_Homo sapiens_hsa053303.16806991
5Autoimmune thyroid disease_Homo sapiens_hsa053203.12675252
6Oxidative phosphorylation_Homo sapiens_hsa001903.06087953
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.83871051
8Antigen processing and presentation_Homo sapiens_hsa046122.67775440
9Asthma_Homo sapiens_hsa053102.65080269
10Type I diabetes mellitus_Homo sapiens_hsa049402.62913744
11Ribosome_Homo sapiens_hsa030102.42462780
12Parkinsons disease_Homo sapiens_hsa050122.33323396
13Phototransduction_Homo sapiens_hsa047442.29727240
14Hematopoietic cell lineage_Homo sapiens_hsa046401.94854850
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.85166186
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.78019639
17Linoleic acid metabolism_Homo sapiens_hsa005911.74196541
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.66135855
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.56852528
20Tryptophan metabolism_Homo sapiens_hsa003801.49083496
21Rheumatoid arthritis_Homo sapiens_hsa053231.46951147
22Alzheimers disease_Homo sapiens_hsa050101.46448525
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.45404152
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.43560518
25Staphylococcus aureus infection_Homo sapiens_hsa051501.36829239
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.34501454
27Nitrogen metabolism_Homo sapiens_hsa009101.34368593
28Huntingtons disease_Homo sapiens_hsa050161.31699171
29Arachidonic acid metabolism_Homo sapiens_hsa005901.24246632
30Viral myocarditis_Homo sapiens_hsa054161.23005495
31Caffeine metabolism_Homo sapiens_hsa002321.19420142
32Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.17995703
33RNA polymerase_Homo sapiens_hsa030201.17907962
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12875592
35T cell receptor signaling pathway_Homo sapiens_hsa046601.12198795
36Peroxisome_Homo sapiens_hsa041461.10911331
37Cardiac muscle contraction_Homo sapiens_hsa042601.07097973
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.01877180
39Olfactory transduction_Homo sapiens_hsa047400.99659796
40Fat digestion and absorption_Homo sapiens_hsa049750.96886543
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.95647804
42SNARE interactions in vesicular transport_Homo sapiens_hsa041300.94998813
43Chemical carcinogenesis_Homo sapiens_hsa052040.93330731
44Sulfur metabolism_Homo sapiens_hsa009200.92715868
45Steroid hormone biosynthesis_Homo sapiens_hsa001400.91929297
46Butanoate metabolism_Homo sapiens_hsa006500.90390861
47Systemic lupus erythematosus_Homo sapiens_hsa053220.86334020
48Retinol metabolism_Homo sapiens_hsa008300.83088702
49NF-kappa B signaling pathway_Homo sapiens_hsa040640.81526551
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81405656
51RNA degradation_Homo sapiens_hsa030180.79707160
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.78708235
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.78489830
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78188486
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.77762466
56Purine metabolism_Homo sapiens_hsa002300.74750208
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72620819
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70837609
59Propanoate metabolism_Homo sapiens_hsa006400.68023475
60Protein export_Homo sapiens_hsa030600.67663041
61Malaria_Homo sapiens_hsa051440.64699328
62Leishmaniasis_Homo sapiens_hsa051400.63831755
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63213051
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62553430
65Measles_Homo sapiens_hsa051620.61691995
66Pyrimidine metabolism_Homo sapiens_hsa002400.60189911
67Histidine metabolism_Homo sapiens_hsa003400.59216824
68Fanconi anemia pathway_Homo sapiens_hsa034600.58772471
69Fatty acid degradation_Homo sapiens_hsa000710.57502509
70Homologous recombination_Homo sapiens_hsa034400.57273526
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56704645
72NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54219020
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.52600946
74Glycerolipid metabolism_Homo sapiens_hsa005610.50783707
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48030895
76ABC transporters_Homo sapiens_hsa020100.47978877
77Ether lipid metabolism_Homo sapiens_hsa005650.47403485
78One carbon pool by folate_Homo sapiens_hsa006700.47212917
79Metabolic pathways_Homo sapiens_hsa011000.46295021
80Taste transduction_Homo sapiens_hsa047420.46061045
81Shigellosis_Homo sapiens_hsa051310.44779383
82Herpes simplex infection_Homo sapiens_hsa051680.44582492
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41152730
84Vitamin digestion and absorption_Homo sapiens_hsa049770.40569737
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.39388981
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39115056
87Selenocompound metabolism_Homo sapiens_hsa004500.37260548
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.36659356
89Nicotine addiction_Homo sapiens_hsa050330.35468247
90beta-Alanine metabolism_Homo sapiens_hsa004100.34692627
91Base excision repair_Homo sapiens_hsa034100.32151276
92Salivary secretion_Homo sapiens_hsa049700.30774380
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.28101599
94Renin-angiotensin system_Homo sapiens_hsa046140.24902802
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.23044810
96Collecting duct acid secretion_Homo sapiens_hsa049660.21882124
97Sulfur relay system_Homo sapiens_hsa041220.20607711
98Pertussis_Homo sapiens_hsa051330.19615605
99Basal transcription factors_Homo sapiens_hsa030220.19219405
100Cyanoamino acid metabolism_Homo sapiens_hsa004600.18387143

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