EEF1A1P16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.37894018
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.00132379
3cytidine metabolic process (GO:0046087)4.81986372
4cytidine catabolic process (GO:0006216)4.81986372
5cytidine deamination (GO:0009972)4.81986372
6energy coupled proton transport, down electrochemical gradient (GO:0015985)4.43818939
7ATP synthesis coupled proton transport (GO:0015986)4.43818939
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.38915756
9ribosomal small subunit assembly (GO:0000028)4.15931136
10pyrimidine ribonucleoside catabolic process (GO:0046133)4.06472646
11water-soluble vitamin biosynthetic process (GO:0042364)4.00684030
12protein neddylation (GO:0045116)3.95628422
13tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.74631725
14RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.74631725
15proteasome assembly (GO:0043248)3.72436265
16regulation of cellular amino acid metabolic process (GO:0006521)3.51440911
17platelet dense granule organization (GO:0060155)3.48799169
18mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.47085542
19protein complex biogenesis (GO:0070271)3.43066349
20rRNA modification (GO:0000154)3.36041027
21establishment of protein localization to mitochondrial membrane (GO:0090151)3.35452658
22nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.33983651
23negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.30480781
24DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.27974228
25regulation of regulatory T cell differentiation (GO:0045589)3.25973268
26GTP biosynthetic process (GO:0006183)3.25872495
27exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.21672179
28regulation of isotype switching to IgG isotypes (GO:0048302)3.21162627
29electron transport chain (GO:0022900)3.19847466
30respiratory electron transport chain (GO:0022904)3.19253412
31signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.18858882
32signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.18858882
33signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.18858882
34signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.15772843
35intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.15772843
36mitochondrial respiratory chain complex assembly (GO:0033108)3.15605031
37pseudouridine synthesis (GO:0001522)3.14470998
38response to pheromone (GO:0019236)3.10303872
39respiratory chain complex IV assembly (GO:0008535)3.08305740
40positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.06893122
41positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.06460047
42signal transduction involved in DNA damage checkpoint (GO:0072422)3.03234293
43signal transduction involved in DNA integrity checkpoint (GO:0072401)3.03234293
44mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.00370965
45mitochondrial respiratory chain complex I assembly (GO:0032981)3.00370965
46NADH dehydrogenase complex assembly (GO:0010257)3.00370965
47regulation of chronic inflammatory response (GO:0002676)2.99175612
48positive regulation of defense response to virus by host (GO:0002230)2.99134708
49signal transduction involved in cell cycle checkpoint (GO:0072395)2.98845518
50L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.97538673
51ribosomal large subunit biogenesis (GO:0042273)2.93312145
52RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.92655035
53negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.90961080
54negative regulation of ligase activity (GO:0051352)2.90961080
55negative T cell selection (GO:0043383)2.90828215
56cytochrome complex assembly (GO:0017004)2.89815178
57positive regulation of T cell mediated cytotoxicity (GO:0001916)2.89661118
58positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.88245739
59chaperone-mediated protein transport (GO:0072321)2.86182250
60regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.85924253
61antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.85264913
62Arp2/3 complex-mediated actin nucleation (GO:0034314)2.83419248
63positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.81655110
64purine nucleoside triphosphate biosynthetic process (GO:0009145)2.80126269
65regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.76941701
66sequestering of actin monomers (GO:0042989)2.76307456
67purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.75223170
68actin nucleation (GO:0045010)2.73308113
69positive regulation of alpha-beta T cell proliferation (GO:0046641)2.70007200
70rRNA methylation (GO:0031167)2.68876174
71antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.68061340
72regulation of T cell mediated cytotoxicity (GO:0001914)2.67634399
73response to interferon-beta (GO:0035456)2.64591172
74UTP biosynthetic process (GO:0006228)2.64173352
75L-methionine salvage (GO:0071267)2.63772325
76L-methionine biosynthetic process (GO:0071265)2.63772325
77amino acid salvage (GO:0043102)2.63772325
78cellular response to interleukin-15 (GO:0071350)2.63671522
79maturation of SSU-rRNA (GO:0030490)2.63104510
80regulation of T cell receptor signaling pathway (GO:0050856)2.62317340
81positive T cell selection (GO:0043368)2.59992567
82ATP biosynthetic process (GO:0006754)2.59228647
83protein deneddylation (GO:0000338)2.58175716
84regulation of leukocyte mediated cytotoxicity (GO:0001910)2.57891131
85termination of RNA polymerase III transcription (GO:0006386)2.57202711
86transcription elongation from RNA polymerase III promoter (GO:0006385)2.57202711
87positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.56558999
88hydrogen ion transmembrane transport (GO:1902600)2.53475113
89mannosylation (GO:0097502)2.52893905
90positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.52876303
91cullin deneddylation (GO:0010388)2.52590827
92anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.52140010
93regulation of cellular amine metabolic process (GO:0033238)2.51562056
94positive regulation of natural killer cell mediated immunity (GO:0002717)2.51237300
95mast cell activation (GO:0045576)2.50907970
96tRNA processing (GO:0008033)2.50894539
97DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.50845103
98translation (GO:0006412)2.50778953
99positive regulation of cell cycle arrest (GO:0071158)2.50735959
100purine-containing compound salvage (GO:0043101)2.49360077

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.00481880
2ELF1_17652178_ChIP-ChIP_JURKAT_Human3.89612054
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.88006231
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.80943302
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.35403291
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.31149255
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.19380147
8VDR_22108803_ChIP-Seq_LS180_Human2.79215662
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.75599460
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.74381112
11VDR_23849224_ChIP-Seq_CD4+_Human2.68043737
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.62179327
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.61809371
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.51564418
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.44339279
16ZNF274_21170338_ChIP-Seq_K562_Hela2.44140974
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.37729845
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.29609960
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.28036701
20ELK1_19687146_ChIP-ChIP_HELA_Human2.19411137
21FOXP3_21729870_ChIP-Seq_TREG_Human2.15961949
22STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.00285612
23SRF_21415370_ChIP-Seq_HL-1_Mouse1.95442386
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.90985784
25FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.89899567
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.89719392
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.86721322
28NOTCH1_21737748_ChIP-Seq_TLL_Human1.81217243
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.80803558
30CREB1_15753290_ChIP-ChIP_HEK293T_Human1.72761006
31IGF1R_20145208_ChIP-Seq_DFB_Human1.60676469
32IRF8_21731497_ChIP-ChIP_J774_Mouse1.58359229
33MYC_18940864_ChIP-ChIP_HL60_Human1.55205154
34GATA3_26560356_Chip-Seq_TH2_Human1.54818196
35MYB_26560356_Chip-Seq_TH2_Human1.51840189
36TP53_22573176_ChIP-Seq_HFKS_Human1.49973346
37MYC_18555785_ChIP-Seq_MESCs_Mouse1.48816062
38EWS_26573619_Chip-Seq_HEK293_Human1.47949616
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.46362757
40EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.41630432
41PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40776858
42FOXA1_25329375_ChIP-Seq_VCAP_Human1.40170563
43FOXA1_27270436_Chip-Seq_PROSTATE_Human1.40170563
44EGR1_23403033_ChIP-Seq_LIVER_Mouse1.38205334
45AR_20517297_ChIP-Seq_VCAP_Human1.36497832
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34803942
47SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.34737198
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30526749
49FUS_26573619_Chip-Seq_HEK293_Human1.25807731
50CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.24177177
51NANOG_19829295_ChIP-Seq_ESCs_Human1.24120003
52SOX2_19829295_ChIP-Seq_ESCs_Human1.24120003
53PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.23774350
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.23631587
55IRF1_19129219_ChIP-ChIP_H3396_Human1.22979660
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.22696927
57ER_23166858_ChIP-Seq_MCF-7_Human1.21273068
58MYC_18358816_ChIP-ChIP_MESCs_Mouse1.21158271
59TAF15_26573619_Chip-Seq_HEK293_Human1.20050505
60ZFP57_27257070_Chip-Seq_ESCs_Mouse1.18141848
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17539839
62NFE2_27457419_Chip-Seq_LIVER_Mouse1.16587333
63YY1_21170310_ChIP-Seq_MESCs_Mouse1.14345344
64GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13930100
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13809250
66SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12614910
67P300_19829295_ChIP-Seq_ESCs_Human1.12390013
68AUTS2_25519132_ChIP-Seq_293T-REX_Human1.12085202
69POU3F2_20337985_ChIP-ChIP_501MEL_Human1.12073579
70GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.10446585
71CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.10171738
72NCOR_22424771_ChIP-Seq_293T_Human1.08907848
73CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08460718
74STAT4_19710469_ChIP-ChIP_TH1__Mouse1.07908903
75ELK1_22589737_ChIP-Seq_MCF10A_Human1.07574857
76POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07254583
77GATA3_27048872_Chip-Seq_THYMUS_Human1.05349218
78TTF2_22483619_ChIP-Seq_HELA_Human1.05291361
79RUNX_20019798_ChIP-Seq_JUKART_Human1.04849385
80E2F4_17652178_ChIP-ChIP_JURKAT_Human1.04234301
81CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.04182951
82NANOG_20526341_ChIP-Seq_ESCs_Human1.02422648
83MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02170679
84GATA3_21878914_ChIP-Seq_MCF-7_Human1.02077584
85EZH2_27294783_Chip-Seq_NPCs_Mouse1.01994214
86CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00659003
87FOXH1_21741376_ChIP-Seq_EPCs_Human1.00006144
88LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.99470323
89DCP1A_22483619_ChIP-Seq_HELA_Human0.98885141
90FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98191684
91TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.98018358
92PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96787044
93IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96759340
94CBP_20019798_ChIP-Seq_JUKART_Human0.96759340
95FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96595105
96TAF2_19829295_ChIP-Seq_ESCs_Human0.96521180
97GABP_19822575_ChIP-Seq_HepG2_Human0.95344367
98RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.95111162
99HTT_18923047_ChIP-ChIP_STHdh_Human0.93562211
100EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.91850803

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.16320879
2MP0001835_abnormal_antigen_presentation3.46923845
3MP0003646_muscle_fatigue2.67181945
4MP0009785_altered_susceptibility_to2.44178896
5MP0006072_abnormal_retinal_apoptosis2.43903088
6MP0002102_abnormal_ear_morphology2.41279998
7MP0005645_abnormal_hypothalamus_physiol2.28780637
8MP0000372_irregular_coat_pigmentation2.24555977
9MP0008872_abnormal_physiological_respon2.21561113
10MP0002166_altered_tumor_susceptibility2.08767300
11MP0008875_abnormal_xenobiotic_pharmacok2.05829228
12MP0005084_abnormal_gallbladder_morpholo2.04487981
13MP0008877_abnormal_DNA_methylation2.03648958
14MP0002148_abnormal_hypersensitivity_rea2.03092258
15MP0002138_abnormal_hepatobiliary_system1.97766203
16MP0001800_abnormal_humoral_immune1.96513904
17MP0005000_abnormal_immune_tolerance1.92028168
18MP0000685_abnormal_immune_system1.91862593
19MP0003195_calcinosis1.91013902
20MP0004147_increased_porphyrin_level1.90366150
21MP0003786_premature_aging1.86163274
22MP0001873_stomach_inflammation1.85087501
23MP0002006_tumorigenesis1.81337687
24MP0003763_abnormal_thymus_physiology1.81144122
25MP0005646_abnormal_pituitary_gland1.80728447
26MP0005075_abnormal_melanosome_morpholog1.78349906
27MP0009333_abnormal_splenocyte_physiolog1.77174212
28MP0003806_abnormal_nucleotide_metabolis1.77166462
29MP0002876_abnormal_thyroid_physiology1.77026356
30MP0008058_abnormal_DNA_repair1.76557926
31MP0002163_abnormal_gland_morphology1.70260289
32MP0002723_abnormal_immune_serum1.66279985
33MP0003866_abnormal_defecation1.65894454
34MP0005387_immune_system_phenotype1.64245868
35MP0001790_abnormal_immune_system1.64245868
36MP0002837_dystrophic_cardiac_calcinosis1.63780428
37MP0002420_abnormal_adaptive_immunity1.56952187
38MP0001819_abnormal_immune_cell1.53244486
39MP0006292_abnormal_olfactory_placode1.51409804
40MP0005551_abnormal_eye_electrophysiolog1.50179818
41MP0001919_abnormal_reproductive_system1.49780115
42MP0002736_abnormal_nociception_after1.47628818
43MP0002452_abnormal_antigen_presenting1.43754331
44MP0001968_abnormal_touch/_nociception1.43106301
45MP0005389_reproductive_system_phenotype1.41765827
46MP0004145_abnormal_muscle_electrophysio1.38652975
47MP0009764_decreased_sensitivity_to1.36364931
48MP0005379_endocrine/exocrine_gland_phen1.33003002
49MP0005253_abnormal_eye_physiology1.32978386
50MP0005025_abnormal_response_to1.32867098
51MP0003724_increased_susceptibility_to1.30572426
52MP0003011_delayed_dark_adaptation1.29605381
53MP0004885_abnormal_endolymph1.27333411
54MP0001986_abnormal_taste_sensitivity1.25918298
55MP0010155_abnormal_intestine_physiology1.25059025
56MP0001905_abnormal_dopamine_level1.22597477
57MP0009379_abnormal_foot_pigmentation1.20951776
58MP0001764_abnormal_homeostasis1.20590768
59MP0002398_abnormal_bone_marrow1.20346988
60MP0006036_abnormal_mitochondrial_physio1.17423575
61MP0000716_abnormal_immune_system1.17370201
62MP0000689_abnormal_spleen_morphology1.13972243
63MP0001845_abnormal_inflammatory_respons1.13271969
64MP0004142_abnormal_muscle_tone1.12824669
65MP0003252_abnormal_bile_duct1.12358260
66MP0006082_CNS_inflammation1.10040460
67MP0008995_early_reproductive_senescence1.07278046
68MP0005410_abnormal_fertilization1.00895128
69MP0002722_abnormal_immune_system0.98669830
70MP0001529_abnormal_vocalization0.98205734
71MP0002160_abnormal_reproductive_system0.97899573
72MP0005636_abnormal_mineral_homeostasis0.95795944
73MP0002693_abnormal_pancreas_physiology0.95172059
74MP0002405_respiratory_system_inflammati0.94318863
75MP0003186_abnormal_redox_activity0.92356605
76MP0002429_abnormal_blood_cell0.91979982
77MP0008469_abnormal_protein_level0.88946054
78MP0000703_abnormal_thymus_morphology0.88902128
79MP0003878_abnormal_ear_physiology0.86079414
80MP0005377_hearing/vestibular/ear_phenot0.86079414
81MP0001501_abnormal_sleep_pattern0.85605164
82MP0006035_abnormal_mitochondrial_morpho0.83813485
83MP0009697_abnormal_copulation0.83209679
84MP0001853_heart_inflammation0.83193310
85MP0002277_abnormal_respiratory_mucosa0.82915040
86MP0003718_maternal_effect0.81541754
87MP0003436_decreased_susceptibility_to0.80062162
88MP0005085_abnormal_gallbladder_physiolo0.79264374
89MP0002419_abnormal_innate_immunity0.77524348
90MP0002638_abnormal_pupillary_reflex0.76248204
91MP0002933_joint_inflammation0.75280511
92MP0006276_abnormal_autonomic_nervous0.74820792
93MP0005167_abnormal_blood-brain_barrier0.72068529
94MP0004043_abnormal_pH_regulation0.71224910
95MP0005332_abnormal_amino_acid0.71175797
96MP0010386_abnormal_urinary_bladder0.70599062
97MP0002019_abnormal_tumor_incidence0.70347721
98MP0002272_abnormal_nervous_system0.70267114
99MP0003693_abnormal_embryo_hatching0.69343757
100MP0001119_abnormal_female_reproductive0.68083340

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.97593633
2Mitochondrial inheritance (HP:0001427)3.85883038
3Increased hepatocellular lipid droplets (HP:0006565)3.75583245
4IgG deficiency (HP:0004315)3.74502041
5Increased CSF lactate (HP:0002490)3.61653072
6Lipid accumulation in hepatocytes (HP:0006561)3.59939136
73-Methylglutaconic aciduria (HP:0003535)3.56617658
8Abnormal mitochondria in muscle tissue (HP:0008316)3.53441439
9Acute encephalopathy (HP:0006846)3.48312550
10Congenital stationary night blindness (HP:0007642)3.40948045
11Hepatocellular necrosis (HP:0001404)3.38119341
12Progressive macrocephaly (HP:0004481)3.35208711
13Elevated erythrocyte sedimentation rate (HP:0003565)3.19321178
14Hepatic necrosis (HP:0002605)3.16977656
15Hypoproteinemia (HP:0003075)3.12843920
16Stomatitis (HP:0010280)3.10524815
17Absent rod-and cone-mediated responses on ERG (HP:0007688)3.09317257
18Methylmalonic acidemia (HP:0002912)2.99272805
19Abnormality of T cell number (HP:0011839)2.97223869
20Increased intramyocellular lipid droplets (HP:0012240)2.96250786
21Autoimmune hemolytic anemia (HP:0001890)2.91765076
22Pancreatic cysts (HP:0001737)2.91216092
23Renal Fanconi syndrome (HP:0001994)2.90513708
24Increased IgM level (HP:0003496)2.88451742
25Severe combined immunodeficiency (HP:0004430)2.84542859
26Aplastic anemia (HP:0001915)2.80538514
27Abolished electroretinogram (ERG) (HP:0000550)2.78108421
28Increased serum lactate (HP:0002151)2.77810997
29T lymphocytopenia (HP:0005403)2.77402664
30Abnormal rod and cone electroretinograms (HP:0008323)2.76737449
31Decreased electroretinogram (ERG) amplitude (HP:0000654)2.69062373
32Cerebral edema (HP:0002181)2.62122714
33Exertional dyspnea (HP:0002875)2.60184409
34Attenuation of retinal blood vessels (HP:0007843)2.59259242
35Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.56682333
36Decreased activity of mitochondrial respiratory chain (HP:0008972)2.56414448
37Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.56414448
38Optic disc pallor (HP:0000543)2.56246168
39Abnormality of T cells (HP:0002843)2.54345369
40Lactic acidosis (HP:0003128)2.49081537
41Methylmalonic aciduria (HP:0012120)2.48452920
42Increased muscle lipid content (HP:0009058)2.47796827
43Decreased central vision (HP:0007663)2.47346546
44Abnormality of the prostate (HP:0008775)2.47034464
45Abnormality of the renal cortex (HP:0011035)2.45482203
46Renal cortical cysts (HP:0000803)2.42527659
47True hermaphroditism (HP:0010459)2.40909740
48Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.40888168
49Abnormality of alanine metabolism (HP:0010916)2.40142090
50Hyperalaninemia (HP:0003348)2.40142090
51Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.40142090
52Abnormality of B cell number (HP:0010975)2.36097991
53Pancreatic fibrosis (HP:0100732)2.34692426
54Thyroiditis (HP:0100646)2.34645089
55Abnormality of eosinophils (HP:0001879)2.23833538
56Pendular nystagmus (HP:0012043)2.20817868
57Constricted visual fields (HP:0001133)2.16027458
58Abnormality of midbrain morphology (HP:0002418)2.15262806
59Molar tooth sign on MRI (HP:0002419)2.15262806
60Autoimmune thrombocytopenia (HP:0001973)2.12973413
61Pancytopenia (HP:0001876)2.12167661
62Nephronophthisis (HP:0000090)2.11784795
63Abnormality of T cell physiology (HP:0011840)2.09566164
64Lethargy (HP:0001254)2.09173334
65Keratoconus (HP:0000563)2.08578168
66Increased corneal curvature (HP:0100692)2.08578168
67Combined immunodeficiency (HP:0005387)2.08558517
68Congenital, generalized hypertrichosis (HP:0004540)2.08178559
69Glycosuria (HP:0003076)2.05360719
70Abnormality of urine glucose concentration (HP:0011016)2.05360719
71Eosinophilia (HP:0001880)2.02008575
72Testicular atrophy (HP:0000029)1.99063881
73Hyperglycinemia (HP:0002154)1.98511169
74Respiratory failure (HP:0002878)1.96293144
75Abnormal delayed hypersensitivity skin test (HP:0002963)1.94618227
76Abnormality of dicarboxylic acid metabolism (HP:0010995)1.94551075
77Dicarboxylic aciduria (HP:0003215)1.94551075
78Aplasia/hypoplasia of the uterus (HP:0008684)1.90940226
79Type I transferrin isoform profile (HP:0003642)1.89730834
80Medial flaring of the eyebrow (HP:0010747)1.86615789
81Hypoalbuminemia (HP:0003073)1.85996010
82Abnormal albumin level (HP:0012116)1.85996010
83Abnormal number of erythroid precursors (HP:0012131)1.85406987
84Abnormality of the renal medulla (HP:0100957)1.83995539
85Exercise intolerance (HP:0003546)1.83967861
86Generalized aminoaciduria (HP:0002909)1.83647885
87Abnormality of serum amino acid levels (HP:0003112)1.82442754
88Panhypogammaglobulinemia (HP:0003139)1.82433725
89Chronic diarrhea (HP:0002028)1.81703242
90Ketosis (HP:0001946)1.81196323
91Abnormality of aspartate family amino acid metabolism (HP:0010899)1.81059508
92Abnormality of renal resorption (HP:0011038)1.80874576
93Type II lissencephaly (HP:0007260)1.78996960
94Prostate neoplasm (HP:0100787)1.78495937
95B lymphocytopenia (HP:0010976)1.77702851
96Abnormal protein glycosylation (HP:0012346)1.77229779
97Abnormal glycosylation (HP:0012345)1.77229779
98Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.77229779
99Abnormal protein N-linked glycosylation (HP:0012347)1.77229779
100Aplasia/Hypoplasia of the spleen (HP:0010451)1.77205213

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.10521793
2TLK13.37060037
3ZAK3.21278800
4VRK22.80979715
5TAOK32.76360852
6KDR2.47613967
7ADRBK22.45518141
8NUAK12.45000870
9MAP4K22.35453211
10MST42.10556245
11BCKDK1.96245294
12GRK11.96055160
13FRK1.86540924
14VRK11.85867539
15PASK1.83137779
16TESK21.81831354
17MAP4K11.75806708
18EIF2AK31.75665529
19TIE11.72294917
20MAP3K121.66902855
21WNK41.62738083
22TEC1.59898772
23PINK11.58644756
24SCYL21.55835491
25BUB11.53766610
26ITK1.51610291
27BMPR1B1.46413033
28BMPR21.33246896
29FES1.19249510
30GRK61.12284729
31IKBKB1.12085597
32OXSR11.07713478
33WNK31.07674871
34STK161.06770436
35CAMKK21.05690250
36CDK191.05082083
37SRPK11.04625365
38SYK1.04528118
39KIT1.00879720
40MAP2K60.95809639
41STK390.95695157
42NME20.94770247
43CSNK1G30.94537355
44PBK0.94485641
45TRIM280.91173028
46INSRR0.90480587
47RPS6KA50.89152994
48DAPK10.87880655
49TSSK60.87537513
50NEK10.85332266
51MYLK0.85129699
52MUSK0.82482237
53PRKCQ0.81195002
54ERBB30.80183941
55PLK30.79608718
56PHKG20.78814604
57PHKG10.78814604
58MAPKAPK30.77338060
59IKBKE0.76063138
60CSNK1G10.76044360
61BTK0.72852953
62LCK0.72248849
63CSNK1G20.71922308
64DYRK20.71173438
65PLK40.68912955
66CSNK1A1L0.64123155
67CSF1R0.62370133
68MKNK10.62188478
69TGFBR10.59476643
70LYN0.58105620
71GRK70.57801144
72NME10.56583641
73ACVR1B0.56191871
74ADRBK10.56176818
75EIF2AK20.55321524
76LIMK10.52625156
77JAK30.52354209
78BRSK20.52293400
79PIK3CG0.51840039
80PLK20.48673788
81TRPM70.47360161
82IGF1R0.46398187
83BCR0.46294089
84DAPK20.46169038
85OBSCN0.44858416
86ZAP700.44469661
87RPS6KA40.44167234
88EIF2AK10.44142696
89TAF10.43140082
90CDK80.41916294
91PLK10.38054435
92PIM10.37923070
93GRK50.37037340
94PRKCE0.36603744
95CSNK2A10.36507172
96MAPK130.36130893
97RIPK40.35887624
98MAPKAPK50.35106766
99ATR0.34774266
100MAP3K140.34184987

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.28322084
2Oxidative phosphorylation_Homo sapiens_hsa001903.19707846
3Primary immunodeficiency_Homo sapiens_hsa053402.98103376
4Ribosome_Homo sapiens_hsa030102.83295208
5Allograft rejection_Homo sapiens_hsa053302.82722847
6Graft-versus-host disease_Homo sapiens_hsa053322.80466644
7Asthma_Homo sapiens_hsa053102.77310707
8Autoimmune thyroid disease_Homo sapiens_hsa053202.73956307
9Parkinsons disease_Homo sapiens_hsa050122.53988269
10Type I diabetes mellitus_Homo sapiens_hsa049402.36322826
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.27194385
12Protein export_Homo sapiens_hsa030602.26207842
13Antigen processing and presentation_Homo sapiens_hsa046122.13637053
14RNA polymerase_Homo sapiens_hsa030202.11449455
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.74442067
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.66712294
17Alzheimers disease_Homo sapiens_hsa050101.66379684
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.65944568
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.63672087
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.61317560
21Homologous recombination_Homo sapiens_hsa034401.55842081
22Huntingtons disease_Homo sapiens_hsa050161.51186118
23Nitrogen metabolism_Homo sapiens_hsa009101.49806845
24RNA degradation_Homo sapiens_hsa030181.46145026
25Phototransduction_Homo sapiens_hsa047441.45834433
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.43268403
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.41566365
28One carbon pool by folate_Homo sapiens_hsa006701.35674596
29Hematopoietic cell lineage_Homo sapiens_hsa046401.34762479
30Rheumatoid arthritis_Homo sapiens_hsa053231.30420698
31Basal transcription factors_Homo sapiens_hsa030221.25855778
32Linoleic acid metabolism_Homo sapiens_hsa005911.24863155
33Propanoate metabolism_Homo sapiens_hsa006401.17090923
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14250544
35Cardiac muscle contraction_Homo sapiens_hsa042601.12914624
36Pyrimidine metabolism_Homo sapiens_hsa002401.12348736
37Fanconi anemia pathway_Homo sapiens_hsa034601.11597026
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.06276549
39Mismatch repair_Homo sapiens_hsa034301.05742428
40Peroxisome_Homo sapiens_hsa041461.03657948
41Caffeine metabolism_Homo sapiens_hsa002321.02745246
42Systemic lupus erythematosus_Homo sapiens_hsa053221.02604378
43Sulfur metabolism_Homo sapiens_hsa009200.99168058
44Spliceosome_Homo sapiens_hsa030400.99034513
45Nucleotide excision repair_Homo sapiens_hsa034200.98193697
46DNA replication_Homo sapiens_hsa030300.96027865
47Maturity onset diabetes of the young_Homo sapiens_hsa049500.95402879
48Purine metabolism_Homo sapiens_hsa002300.95396046
49T cell receptor signaling pathway_Homo sapiens_hsa046600.92536854
50RNA transport_Homo sapiens_hsa030130.92532816
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90618163
52Butanoate metabolism_Homo sapiens_hsa006500.83939373
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81925168
54Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.80800424
55Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.79341017
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.76194331
57Selenocompound metabolism_Homo sapiens_hsa004500.74792591
58Chemical carcinogenesis_Homo sapiens_hsa052040.74148497
59Regulation of autophagy_Homo sapiens_hsa041400.73780932
60Viral myocarditis_Homo sapiens_hsa054160.72869091
61Non-homologous end-joining_Homo sapiens_hsa034500.70797160
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69708857
63Arachidonic acid metabolism_Homo sapiens_hsa005900.69632474
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.68795765
65Base excision repair_Homo sapiens_hsa034100.68781063
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68348666
67Collecting duct acid secretion_Homo sapiens_hsa049660.66943244
68Ether lipid metabolism_Homo sapiens_hsa005650.66931771
69Tryptophan metabolism_Homo sapiens_hsa003800.64729526
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.63591495
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62036347
72Retinol metabolism_Homo sapiens_hsa008300.61621117
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57272591
74NOD-like receptor signaling pathway_Homo sapiens_hsa046210.57054336
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56854727
76Metabolic pathways_Homo sapiens_hsa011000.55481751
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.55242014
78Olfactory transduction_Homo sapiens_hsa047400.52576700
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50442062
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50315633
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49764986
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45560407
83Measles_Homo sapiens_hsa051620.45420445
84Glutathione metabolism_Homo sapiens_hsa004800.44341335
85Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.42858176
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42483493
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.42073962
88Staphylococcus aureus infection_Homo sapiens_hsa051500.40998208
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.40976198
90Herpes simplex infection_Homo sapiens_hsa051680.39022018
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38004279
92Leishmaniasis_Homo sapiens_hsa051400.34742524
93Fat digestion and absorption_Homo sapiens_hsa049750.33784584
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33503624
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31920037
96RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.31617245
97Epstein-Barr virus infection_Homo sapiens_hsa051690.27121370
98Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.26902787
99Taste transduction_Homo sapiens_hsa047420.26499924
100Salivary secretion_Homo sapiens_hsa049700.26188585

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