EEF1A1P15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.75062413
2positive regulation of defense response to virus by host (GO:0002230)4.12564458
3cellular response to exogenous dsRNA (GO:0071360)4.05768422
4mitochondrial respiratory chain complex I assembly (GO:0032981)4.05617646
5NADH dehydrogenase complex assembly (GO:0010257)4.05617646
6mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.05617646
7proteasome assembly (GO:0043248)3.73074565
8regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.72671520
9protein complex biogenesis (GO:0070271)3.64706296
10GTP biosynthetic process (GO:0006183)3.60673538
11RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.58174673
12tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.58174673
13water-soluble vitamin biosynthetic process (GO:0042364)3.57604643
14mitochondrial respiratory chain complex assembly (GO:0033108)3.34450105
15regulation of germinal center formation (GO:0002634)3.27211606
16interferon-gamma secretion (GO:0072643)3.26794809
17piRNA metabolic process (GO:0034587)3.26049856
18rRNA modification (GO:0000154)3.26031265
19positive regulation of prostaglandin secretion (GO:0032308)3.24663022
20energy coupled proton transport, down electrochemical gradient (GO:0015985)3.22197580
21ATP synthesis coupled proton transport (GO:0015986)3.22197580
22protein deneddylation (GO:0000338)3.20663727
23nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.19808834
24pseudouridine synthesis (GO:0001522)3.17190285
25regulation of chronic inflammatory response (GO:0002676)3.09946830
26exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.04288662
27DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.03712719
28UTP biosynthetic process (GO:0006228)3.02704473
29regulation of cellular amino acid metabolic process (GO:0006521)3.02314083
30RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.98677602
31regulation of regulatory T cell differentiation (GO:0045589)2.97414811
32positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.97123912
33L-fucose metabolic process (GO:0042354)2.96645365
34L-fucose catabolic process (GO:0042355)2.96645365
35fucose catabolic process (GO:0019317)2.96645365
36positive regulation of T cell mediated cytotoxicity (GO:0001916)2.96434759
37response to interferon-beta (GO:0035456)2.96247226
38regulation of defense response to virus by host (GO:0050691)2.95923403
39regulation of DNA endoreduplication (GO:0032875)2.95269260
40response to xenobiotic stimulus (GO:0009410)2.92599219
41cullin deneddylation (GO:0010388)2.91638528
42maturation of 5.8S rRNA (GO:0000460)2.91502255
43regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.91073060
44cytidine metabolic process (GO:0046087)2.90477994
45cytidine catabolic process (GO:0006216)2.90477994
46cytidine deamination (GO:0009972)2.90477994
47positive regulation of T-helper 1 type immune response (GO:0002827)2.88755402
48ribosomal small subunit assembly (GO:0000028)2.86211123
49behavioral response to nicotine (GO:0035095)2.86059343
50L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.85685897
51activated T cell proliferation (GO:0050798)2.85378957
52DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.81187312
53transcription elongation from RNA polymerase III promoter (GO:0006385)2.80587984
54termination of RNA polymerase III transcription (GO:0006386)2.80587984
55tRNA processing (GO:0008033)2.80390486
56DNA damage response, signal transduction resulting in transcription (GO:0042772)2.78641195
57UTP metabolic process (GO:0046051)2.76710216
58sulfation (GO:0051923)2.73675346
59signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.72588813
60signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.72588813
61signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.72588813
62positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.71736474
63protein polyglutamylation (GO:0018095)2.69283438
64signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.68899340
65intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.68899340
66negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.68520764
67mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.67820000
68protein K6-linked ubiquitination (GO:0085020)2.67205901
69mesonephros development (GO:0001823)2.66795964
70signal transduction involved in DNA integrity checkpoint (GO:0072401)2.66687717
71signal transduction involved in DNA damage checkpoint (GO:0072422)2.66687717
72tRNA modification (GO:0006400)2.65453442
73DNA methylation involved in gamete generation (GO:0043046)2.62605796
74signal transduction involved in cell cycle checkpoint (GO:0072395)2.62310247
75establishment of protein localization to mitochondrial membrane (GO:0090151)2.61644106
76response to gravity (GO:0009629)2.60447796
77adenosine metabolic process (GO:0046085)2.60336945
78preassembly of GPI anchor in ER membrane (GO:0016254)2.60206587
79regulation of isotype switching to IgG isotypes (GO:0048302)2.57873305
80sleep (GO:0030431)2.57343495
81regulation of T cell receptor signaling pathway (GO:0050856)2.57098694
82protein neddylation (GO:0045116)2.56813669
83protein-cofactor linkage (GO:0018065)2.56795281
84cellular response to dsRNA (GO:0071359)2.56744875
85chaperone-mediated protein transport (GO:0072321)2.56437412
86kynurenine metabolic process (GO:0070189)2.54581174
87regulation of prostaglandin secretion (GO:0032306)2.54206120
88auditory receptor cell stereocilium organization (GO:0060088)2.52430177
89detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.52288407
90CTP biosynthetic process (GO:0006241)2.51585398
91CTP metabolic process (GO:0046036)2.51585398
92positive regulation of fatty acid transport (GO:2000193)2.51526153
93L-methionine salvage (GO:0071267)2.50788686
94L-methionine biosynthetic process (GO:0071265)2.50788686
95amino acid salvage (GO:0043102)2.50788686
96positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.50359955
97regulation of T cell mediated cytotoxicity (GO:0001914)2.50224556
98positive regulation of DNA recombination (GO:0045911)2.49819741
99somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.49560519
100isotype switching (GO:0045190)2.49560519

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.28204322
2ELF1_17652178_ChIP-ChIP_JURKAT_Human4.12814883
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.84447943
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.80074271
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.45442604
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.28189130
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.22159634
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.94598401
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.88560689
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.86254405
11VDR_22108803_ChIP-Seq_LS180_Human2.82927161
12VDR_23849224_ChIP-Seq_CD4+_Human2.66304356
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.46721017
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.40466473
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.37610803
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.33503923
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.32492967
18ZNF274_21170338_ChIP-Seq_K562_Hela2.31805926
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.28624021
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.22227830
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.14628464
22ELK1_19687146_ChIP-ChIP_HELA_Human2.11416544
23FOXP3_21729870_ChIP-Seq_TREG_Human2.04643984
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.99827626
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.85861471
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.82794547
27EWS_26573619_Chip-Seq_HEK293_Human1.80406688
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.78591530
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72104811
30PCGF2_27294783_Chip-Seq_NPCs_Mouse1.66165419
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.64760492
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.61300750
33MYC_18940864_ChIP-ChIP_HL60_Human1.59169059
34CREB1_15753290_ChIP-ChIP_HEK293T_Human1.55514457
35GATA3_26560356_Chip-Seq_TH2_Human1.55369156
36CIITA_25753668_ChIP-Seq_RAJI_Human1.55357966
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.51641076
38BP1_19119308_ChIP-ChIP_Hs578T_Human1.45706039
39EGR1_23403033_ChIP-Seq_LIVER_Mouse1.43827536
40EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42134171
41TP53_22573176_ChIP-Seq_HFKS_Human1.41054043
42FUS_26573619_Chip-Seq_HEK293_Human1.30139505
43IRF1_19129219_ChIP-ChIP_H3396_Human1.29606580
44STAT4_19710469_ChIP-ChIP_TH1__Mouse1.29503724
45PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28514888
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27881360
47MYC_18555785_ChIP-Seq_MESCs_Mouse1.27231295
48YY1_21170310_ChIP-Seq_MESCs_Mouse1.25260045
49SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.24994068
50CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.24217516
51IGF1R_20145208_ChIP-Seq_DFB_Human1.23175844
52FOXA1_25329375_ChIP-Seq_VCAP_Human1.22894181
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.22894181
54MYB_26560356_Chip-Seq_TH2_Human1.22502983
55MYC_18358816_ChIP-ChIP_MESCs_Mouse1.21866466
56GBX2_23144817_ChIP-Seq_PC3_Human1.21460660
57GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21054264
58IRF8_21731497_ChIP-ChIP_J774_Mouse1.20802828
59PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.20503123
60FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19897104
61CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.17628694
62AR_20517297_ChIP-Seq_VCAP_Human1.16245762
63ER_23166858_ChIP-Seq_MCF-7_Human1.15524252
64ELK1_22589737_ChIP-Seq_MCF10A_Human1.13613977
65NANOG_19829295_ChIP-Seq_ESCs_Human1.12831904
66SOX2_19829295_ChIP-Seq_ESCs_Human1.12831904
67SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.12317714
68MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11385879
69FOXH1_21741376_ChIP-Seq_EPCs_Human1.09032276
70FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.06124500
71GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05888974
72AUTS2_25519132_ChIP-Seq_293T-REX_Human1.05586581
73CTBP1_25329375_ChIP-Seq_LNCAP_Human1.04769103
74TAF2_19829295_ChIP-Seq_ESCs_Human1.03541777
75GATA3_21878914_ChIP-Seq_MCF-7_Human1.02665392
76TTF2_22483619_ChIP-Seq_HELA_Human1.02215972
77PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01507253
78LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.01218138
79NCOR_22424771_ChIP-Seq_293T_Human1.00541710
80CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.99925853
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99630016
82CBP_20019798_ChIP-Seq_JUKART_Human0.99630016
83SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99564843
84NANOG_20526341_ChIP-Seq_ESCs_Human0.99383931
85DCP1A_22483619_ChIP-Seq_HELA_Human0.99276478
86P300_19829295_ChIP-Seq_ESCs_Human0.98365100
87NFE2_27457419_Chip-Seq_LIVER_Mouse0.97996004
88PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.96497010
89FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95706632
90RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.95679267
91HOXB7_26014856_ChIP-Seq_BT474_Human0.95431991
92E2F4_17652178_ChIP-ChIP_JURKAT_Human0.94998591
93CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.94116868
94HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.94071106
95TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.93968977
96GABP_19822575_ChIP-Seq_HepG2_Human0.92360406
97PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.91791267
98RUNX_20019798_ChIP-Seq_JUKART_Human0.91377400
99TDRD3_21172665_ChIP-Seq_MCF-7_Human0.90909065
100GATA3_27048872_Chip-Seq_THYMUS_Human0.90529115

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to3.49228006
2MP0002138_abnormal_hepatobiliary_system3.43199961
3MP0002736_abnormal_nociception_after3.14468825
4MP0001835_abnormal_antigen_presentation3.10949308
5MP0001968_abnormal_touch/_nociception2.85274698
6MP0000685_abnormal_immune_system2.67887899
7MP0005646_abnormal_pituitary_gland2.66256195
8MP0004885_abnormal_endolymph2.63000640
9MP0002148_abnormal_hypersensitivity_rea2.44958800
10MP0006072_abnormal_retinal_apoptosis2.41497443
11MP0003806_abnormal_nucleotide_metabolis2.40906858
12MP0002163_abnormal_gland_morphology2.36426262
13MP0008877_abnormal_DNA_methylation2.30330487
14MP0003724_increased_susceptibility_to2.19238264
15MP0008872_abnormal_physiological_respon2.18540856
16MP0008875_abnormal_xenobiotic_pharmacok2.15998770
17MP0002102_abnormal_ear_morphology2.07276408
18MP0001800_abnormal_humoral_immune1.93790262
19MP0008058_abnormal_DNA_repair1.87663130
20MP0002876_abnormal_thyroid_physiology1.84616783
21MP0005084_abnormal_gallbladder_morpholo1.82209623
22MP0005000_abnormal_immune_tolerance1.80175079
23MP0000613_abnormal_salivary_gland1.79140757
24MP0009785_altered_susceptibility_to1.78153179
25MP0003436_decreased_susceptibility_to1.71424769
26MP0003786_premature_aging1.69237892
27MP0009764_decreased_sensitivity_to1.68015680
28MP0002006_tumorigenesis1.66827910
29MP0005389_reproductive_system_phenotype1.64782223
30MP0001348_abnormal_lacrimal_gland1.64557173
31MP0003866_abnormal_defecation1.63962516
32MP0002723_abnormal_immune_serum1.56457365
33MP0009333_abnormal_splenocyte_physiolog1.49162823
34MP0002452_abnormal_antigen_presenting1.48569881
35MP0005551_abnormal_eye_electrophysiolog1.47080548
36MP0002160_abnormal_reproductive_system1.46829085
37MP0003718_maternal_effect1.46551669
38MP0002166_altered_tumor_susceptibility1.40512257
39MP0002420_abnormal_adaptive_immunity1.39237671
40MP0001819_abnormal_immune_cell1.38381389
41MP0005379_endocrine/exocrine_gland_phen1.35921821
42MP0001905_abnormal_dopamine_level1.34949423
43MP0000383_abnormal_hair_follicle1.34084783
44MP0001790_abnormal_immune_system1.34001974
45MP0005387_immune_system_phenotype1.34001974
46MP0001873_stomach_inflammation1.33931190
47MP0001919_abnormal_reproductive_system1.33157678
48MP0001501_abnormal_sleep_pattern1.31065805
49MP0005253_abnormal_eye_physiology1.26452946
50MP0004147_increased_porphyrin_level1.24152737
51MP0005645_abnormal_hypothalamus_physiol1.23020339
52MP0004145_abnormal_muscle_electrophysio1.17090951
53MP0003646_muscle_fatigue1.15597436
54MP0000372_irregular_coat_pigmentation1.14693101
55MP0003252_abnormal_bile_duct1.14641950
56MP0003950_abnormal_plasma_membrane1.13611899
57MP0008775_abnormal_heart_ventricle1.11862173
58MP0010155_abnormal_intestine_physiology1.11755558
59MP0005075_abnormal_melanosome_morpholog1.10135954
60MP0003763_abnormal_thymus_physiology1.07894642
61MP0006292_abnormal_olfactory_placode1.06918671
62MP0001533_abnormal_skeleton_physiology1.05466254
63MP0003195_calcinosis1.01738840
64MP0001845_abnormal_inflammatory_respons0.99422942
65MP0005410_abnormal_fertilization0.98351133
66MP0005025_abnormal_response_to0.97531055
67MP0004742_abnormal_vestibular_system0.97001806
68MP0001440_abnormal_grooming_behavior0.95743297
69MP0001986_abnormal_taste_sensitivity0.95421751
70MP0002272_abnormal_nervous_system0.94673042
71MP0003638_abnormal_response/metabolism_0.93536601
72MP0000689_abnormal_spleen_morphology0.93179183
73MP0000647_abnormal_sebaceous_gland0.92851540
74MP0000427_abnormal_hair_cycle0.91869731
75MP0001542_abnormal_bone_strength0.90374615
76MP0002419_abnormal_innate_immunity0.89963633
77MP0000716_abnormal_immune_system0.89960616
78MP0002282_abnormal_trachea_morphology0.89483609
79MP0002405_respiratory_system_inflammati0.88882514
80MP0002733_abnormal_thermal_nociception0.86544698
81MP0002398_abnormal_bone_marrow0.86391144
82MP0004142_abnormal_muscle_tone0.85891018
83MP0005332_abnormal_amino_acid0.83991924
84MP0005165_increased_susceptibility_to0.83091934
85MP0000230_abnormal_systemic_arterial0.82753675
86MP0001765_abnormal_ion_homeostasis0.79743628
87MP0005360_urolithiasis0.79529081
88MP0002722_abnormal_immune_system0.79212971
89MP0002210_abnormal_sex_determination0.77653335
90MP0006036_abnormal_mitochondrial_physio0.77536786
91MP0008469_abnormal_protein_level0.76509234
92MP0001486_abnormal_startle_reflex0.76260133
93MP0002277_abnormal_respiratory_mucosa0.76065657
94MP0001502_abnormal_circadian_rhythm0.74728718
95MP0002429_abnormal_blood_cell0.74372860
96MP0003011_delayed_dark_adaptation0.72185834
97MP0005377_hearing/vestibular/ear_phenot0.71415588
98MP0003878_abnormal_ear_physiology0.71415588
99MP0001529_abnormal_vocalization0.70678680
100MP0009643_abnormal_urine_homeostasis0.70076465

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)3.79270014
2Abolished electroretinogram (ERG) (HP:0000550)3.47336120
3IgG deficiency (HP:0004315)3.46784233
4Acute necrotizing encephalopathy (HP:0006965)3.44954144
5Mitochondrial inheritance (HP:0001427)3.43814240
6Pancreatic cysts (HP:0001737)3.42442681
7Conjunctival hamartoma (HP:0100780)3.30389692
8Hepatocellular necrosis (HP:0001404)3.24621539
9Stomatitis (HP:0010280)3.23441148
10Increased CSF lactate (HP:0002490)3.21730656
11Decreased electroretinogram (ERG) amplitude (HP:0000654)3.20961278
12Abnormality of the renal cortex (HP:0011035)3.13449064
13Abnormal mitochondria in muscle tissue (HP:0008316)3.10374283
14Absent rod-and cone-mediated responses on ERG (HP:0007688)3.08621945
15Acute encephalopathy (HP:0006846)3.07579586
16Congenital stationary night blindness (HP:0007642)3.03437695
17Progressive macrocephaly (HP:0004481)3.01254847
18Hepatic necrosis (HP:0002605)2.92725715
19Abnormality of alanine metabolism (HP:0010916)2.91498453
20Hyperalaninemia (HP:0003348)2.91498453
21Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.91498453
22Prostate neoplasm (HP:0100787)2.87875378
23Abnormality of the prostate (HP:0008775)2.87856845
24Pendular nystagmus (HP:0012043)2.87714374
25Short tibia (HP:0005736)2.83214160
26Hypoplasia of the uterus (HP:0000013)2.80647682
27Renal cortical cysts (HP:0000803)2.75681956
28Molar tooth sign on MRI (HP:0002419)2.74933385
29Abnormality of midbrain morphology (HP:0002418)2.74933385
30Keratoconus (HP:0000563)2.71480578
31Increased corneal curvature (HP:0100692)2.71480578
32Abnormality of the proximal phalanges of the hand (HP:0009834)2.67338310
33Nephronophthisis (HP:0000090)2.62562808
34Aplasia/hypoplasia of the uterus (HP:0008684)2.62096361
35Abnormal number of erythroid precursors (HP:0012131)2.60439279
36Pancreatic fibrosis (HP:0100732)2.59007964
37Increased serum lactate (HP:0002151)2.57785829
38Congenital, generalized hypertrichosis (HP:0004540)2.57177560
39Aplasia/Hypoplasia of the tibia (HP:0005772)2.55669146
40Abnormal rod and cone electroretinograms (HP:0008323)2.54466276
41True hermaphroditism (HP:0010459)2.51574475
423-Methylglutaconic aciduria (HP:0003535)2.50635150
43Attenuation of retinal blood vessels (HP:0007843)2.46657289
44Optic disc pallor (HP:0000543)2.33828005
45Lactic acidosis (HP:0003128)2.33691477
46Abnormality of the renal medulla (HP:0100957)2.32973567
47Asplenia (HP:0001746)2.32737363
48Constricted visual fields (HP:0001133)2.31472603
49Aplasia/Hypoplasia of the spleen (HP:0010451)2.27496886
50Abnormality of the phalanges of the 2nd finger (HP:0009541)2.26687579
51Cerebral edema (HP:0002181)2.25787743
52Congenital sensorineural hearing impairment (HP:0008527)2.24990680
53Stomach cancer (HP:0012126)2.24019465
54Pulmonary infiltrates (HP:0002113)2.21316891
55Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.20544501
56Hypoproteinemia (HP:0003075)2.19973190
57Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.17522253
58Increased IgM level (HP:0003496)2.17242655
59Abnormality of cells of the erythroid lineage (HP:0012130)2.17030628
60Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.10694913
61Hamartoma of the eye (HP:0010568)2.08946958
62Fibular aplasia (HP:0002990)2.08650184
63Methylmalonic acidemia (HP:0002912)2.06747612
64Decreased central vision (HP:0007663)2.05174349
65Abnormality of T cell physiology (HP:0011840)2.04721395
66Abnormal drinking behavior (HP:0030082)2.04332063
67Polydipsia (HP:0001959)2.04332063
68Myositis (HP:0100614)1.97570820
69Increased hepatocellular lipid droplets (HP:0006565)1.97160841
70Absent thumb (HP:0009777)1.96185951
71Lipid accumulation in hepatocytes (HP:0006561)1.95818339
72Type 2 muscle fiber atrophy (HP:0003554)1.95651499
73Furrowed tongue (HP:0000221)1.94869450
74Methylmalonic aciduria (HP:0012120)1.94602892
75Renal Fanconi syndrome (HP:0001994)1.91373722
76Abnormality of the middle phalanges of the toes (HP:0010183)1.91258169
77Type I transferrin isoform profile (HP:0003642)1.88880528
78Adrenal hypoplasia (HP:0000835)1.86300500
79Abnormality of the phalanges of the 5th finger (HP:0004213)1.85321708
80Abnormality of T cells (HP:0002843)1.85037775
81Generalized aminoaciduria (HP:0002909)1.80604826
82Respiratory failure (HP:0002878)1.79477172
83Reduced subcutaneous adipose tissue (HP:0003758)1.78915188
84Hypoplasia of the ulna (HP:0003022)1.77638771
85Adactyly (HP:0009776)1.77135225
86Pancytopenia (HP:0001876)1.75311296
87Abnormality of the ileum (HP:0001549)1.74074659
88Lethargy (HP:0001254)1.73263127
89Polyuria (HP:0000103)1.73156759
90Bone cyst (HP:0012062)1.71320365
91Cystic liver disease (HP:0006706)1.70305161
92Colon cancer (HP:0003003)1.69808986
93Chorioretinal atrophy (HP:0000533)1.68810298
94Palpitations (HP:0001962)1.68654063
95Abnormality of eosinophils (HP:0001879)1.68079765
96Autoimmune hemolytic anemia (HP:0001890)1.66475370
97Retrobulbar optic neuritis (HP:0100654)1.65801817
98Optic neuritis (HP:0100653)1.65801817
99Leukodystrophy (HP:0002415)1.65746188
100Aplasia/Hypoplasia of the ulna (HP:0006495)1.65538116

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK14.17655650
2NME23.68194466
3VRK23.60838076
4TAOK33.58090461
5NUAK13.29958066
6ZAK2.82263687
7TXK2.74220176
8MAP4K22.52511534
9BCKDK2.40945141
10ADRBK22.16738836
11MAPKAPK32.12145610
12FRK2.07214081
13GRK11.89717417
14VRK11.87217480
15BUB11.82222207
16TIE11.70588618
17CSNK1G31.62181150
18MAP4K11.60277361
19MST41.54589603
20GRK61.51405747
21TEC1.45932405
22DAPK11.44741891
23PHKG21.43724115
24PHKG11.43724115
25CSNK1A1L1.43217374
26IKBKB1.39980967
27BMPR1B1.37737920
28TAF11.36683776
29WNK41.34468131
30MAP3K141.30804767
31TSSK61.30028247
32CSNK1G11.28287644
33CSNK1G21.26623363
34STK161.24480158
35CDK191.18707239
36SCYL21.16428182
37GRK51.11768590
38NEK11.10626072
39PINK11.09909799
40FES0.99884886
41ITK0.99513201
42KDR0.97478168
43EIF2AK30.97398587
44EIF2AK20.92652865
45OXSR10.88864400
46KIT0.83983876
47CDK80.82948718
48LMTK20.79399021
49INSRR0.78952617
50MAPKAPK50.77393739
51TESK20.77330214
52MAP3K120.76060389
53PLK30.75660168
54SYK0.71932319
55RPS6KA50.69338514
56PTK2B0.69314241
57FLT30.67459061
58MYLK0.67096253
59MAP2K60.66788381
60WNK30.66028044
61IKBKE0.65607459
62ADRBK10.63816128
63MAP2K20.62456636
64JAK30.59392651
65PRKCQ0.58923234
66RPS6KB20.54759087
67CHUK0.54490239
68MUSK0.54255836
69TGFBR10.52218808
70CSNK1A10.52159515
71MKNK10.51975901
72LIMK10.49712253
73TBK10.49241680
74BMPR20.48766777
75GRK70.47606073
76SRPK10.46333345
77DYRK20.46119758
78PLK20.45660561
79LCK0.45242200
80BTK0.44738994
81TRIM280.44208705
82LYN0.44184732
83STK38L0.43556854
84CAMKK20.42549427
85IGF1R0.40881387
86PRKCE0.40720557
87EIF2AK10.39632891
88STK390.39395140
89ABL10.39189423
90CSF1R0.39044463
91PASK0.34792811
92AURKA0.34585432
93CAMK2D0.33982918
94CCNB10.32709907
95ERBB30.31827995
96PRKCI0.31457654
97CSNK2A10.31044738
98DAPK20.29925514
99NME10.29575327
100DAPK30.28889182

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.06209008
2Proteasome_Homo sapiens_hsa030503.64101149
3Intestinal immune network for IgA production_Homo sapiens_hsa046723.40770567
4Allograft rejection_Homo sapiens_hsa053303.40212777
5Autoimmune thyroid disease_Homo sapiens_hsa053203.17403711
6Graft-versus-host disease_Homo sapiens_hsa053322.69487545
7Type I diabetes mellitus_Homo sapiens_hsa049402.65929499
8RNA polymerase_Homo sapiens_hsa030202.38310850
9Ribosome_Homo sapiens_hsa030102.30289401
10Oxidative phosphorylation_Homo sapiens_hsa001902.28851022
11One carbon pool by folate_Homo sapiens_hsa006702.17022451
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.04776108
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.94518955
14Antigen processing and presentation_Homo sapiens_hsa046121.82111984
15Primary immunodeficiency_Homo sapiens_hsa053401.77515186
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.75544869
17Protein export_Homo sapiens_hsa030601.67419510
18Parkinsons disease_Homo sapiens_hsa050121.67388933
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.66338571
20Rheumatoid arthritis_Homo sapiens_hsa053231.61812094
21RNA degradation_Homo sapiens_hsa030181.44757723
22Linoleic acid metabolism_Homo sapiens_hsa005911.39603159
23Homologous recombination_Homo sapiens_hsa034401.37316237
24Nitrogen metabolism_Homo sapiens_hsa009101.36210916
25Phototransduction_Homo sapiens_hsa047441.35739220
26Sulfur metabolism_Homo sapiens_hsa009201.33242214
27Pyrimidine metabolism_Homo sapiens_hsa002401.27643336
28Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.25262960
29Systemic lupus erythematosus_Homo sapiens_hsa053221.22915614
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.21544626
31Viral myocarditis_Homo sapiens_hsa054161.16518166
32Selenocompound metabolism_Homo sapiens_hsa004501.15344306
33Alzheimers disease_Homo sapiens_hsa050101.12532979
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.12137565
35Hematopoietic cell lineage_Homo sapiens_hsa046401.11353079
36Mismatch repair_Homo sapiens_hsa034301.10216849
37Huntingtons disease_Homo sapiens_hsa050161.06685847
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06464732
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.05051729
40Purine metabolism_Homo sapiens_hsa002301.04949992
41Nucleotide excision repair_Homo sapiens_hsa034201.03752963
42Spliceosome_Homo sapiens_hsa030401.03502470
43Cyanoamino acid metabolism_Homo sapiens_hsa004601.03096232
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02815967
45Basal transcription factors_Homo sapiens_hsa030221.01874925
46Fanconi anemia pathway_Homo sapiens_hsa034601.01671511
47NF-kappa B signaling pathway_Homo sapiens_hsa040641.00642725
48Regulation of autophagy_Homo sapiens_hsa041400.93675232
49Non-homologous end-joining_Homo sapiens_hsa034500.93483991
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91734694
51RNA transport_Homo sapiens_hsa030130.91050225
52Arachidonic acid metabolism_Homo sapiens_hsa005900.88769646
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.86328919
54Base excision repair_Homo sapiens_hsa034100.86098119
55DNA replication_Homo sapiens_hsa030300.82425964
56Ether lipid metabolism_Homo sapiens_hsa005650.78371038
57Caffeine metabolism_Homo sapiens_hsa002320.76135230
58Fatty acid elongation_Homo sapiens_hsa000620.75808756
59Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.75601509
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74668368
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73999003
62Herpes simplex infection_Homo sapiens_hsa051680.70303456
63Chemical carcinogenesis_Homo sapiens_hsa052040.69467822
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69196163
65Cardiac muscle contraction_Homo sapiens_hsa042600.67223933
66Peroxisome_Homo sapiens_hsa041460.66252962
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.64349557
68T cell receptor signaling pathway_Homo sapiens_hsa046600.63605084
69Propanoate metabolism_Homo sapiens_hsa006400.62686918
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61988405
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.61012487
72Tryptophan metabolism_Homo sapiens_hsa003800.60198828
73Leishmaniasis_Homo sapiens_hsa051400.59126927
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58694280
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57428058
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57014806
77Staphylococcus aureus infection_Homo sapiens_hsa051500.56763669
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56593340
79Collecting duct acid secretion_Homo sapiens_hsa049660.53316630
80Salivary secretion_Homo sapiens_hsa049700.52196208
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51671953
82Retinol metabolism_Homo sapiens_hsa008300.49580123
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47474641
84Metabolic pathways_Homo sapiens_hsa011000.44771845
85Measles_Homo sapiens_hsa051620.41557636
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37950628
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37546842
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.36953512
89Epstein-Barr virus infection_Homo sapiens_hsa051690.36352033
90Glutathione metabolism_Homo sapiens_hsa004800.35879932
91RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.34866301
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.31794169
93Morphine addiction_Homo sapiens_hsa050320.29777560
94Jak-STAT signaling pathway_Homo sapiens_hsa046300.28835245
95Taste transduction_Homo sapiens_hsa047420.27939386
96Fat digestion and absorption_Homo sapiens_hsa049750.26661796
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.23046385
98Legionellosis_Homo sapiens_hsa051340.22184123
99Vitamin digestion and absorption_Homo sapiens_hsa049770.21532878
100Olfactory transduction_Homo sapiens_hsa047400.20609469

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