EED

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein interacts with enhancer of zeste 2, the cytoplasmic tail of integrin beta7, immunodeficiency virus type 1 (HIV-1) MA protein, and histone deacetylase proteins. This protein mediates repression of gene activity through histone deacetylation, and may act as a specific regulator of integrin function. Two transcript variants encoding distinct isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)4.96877082
2DNA replication initiation (GO:0006270)4.63997867
3DNA strand elongation involved in DNA replication (GO:0006271)4.56166569
4DNA replication checkpoint (GO:0000076)4.55139735
5DNA double-strand break processing (GO:0000729)4.51446353
6mitotic metaphase plate congression (GO:0007080)4.45486871
7DNA strand elongation (GO:0022616)4.36877514
8protein localization to kinetochore (GO:0034501)4.33617830
9telomere maintenance via semi-conservative replication (GO:0032201)4.28127682
10formation of translation preinitiation complex (GO:0001731)4.22973371
11chromatin remodeling at centromere (GO:0031055)4.12654468
12maturation of SSU-rRNA (GO:0030490)4.10532117
13DNA unwinding involved in DNA replication (GO:0006268)4.09442228
14CENP-A containing nucleosome assembly (GO:0034080)4.08748861
15negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.06405519
16nuclear pore organization (GO:0006999)4.03278818
17regulation of DNA endoreduplication (GO:0032875)3.99753677
18DNA replication-dependent nucleosome assembly (GO:0006335)3.96671626
19DNA replication-dependent nucleosome organization (GO:0034723)3.96671626
20nucleobase biosynthetic process (GO:0046112)3.96043487
21mitotic nuclear envelope disassembly (GO:0007077)3.95981764
22telomere maintenance via recombination (GO:0000722)3.94819916
23nuclear pore complex assembly (GO:0051292)3.89720584
24regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.88735319
25ribosome assembly (GO:0042255)3.88580579
26metaphase plate congression (GO:0051310)3.88122542
27positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.84690686
28DNA replication-independent nucleosome assembly (GO:0006336)3.80079772
29DNA replication-independent nucleosome organization (GO:0034724)3.80079772
30establishment of integrated proviral latency (GO:0075713)3.79871985
31mitotic recombination (GO:0006312)3.78935938
32anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.78908682
33purine nucleobase biosynthetic process (GO:0009113)3.76317865
34DNA ligation (GO:0006266)3.74570663
35DNA catabolic process, exonucleolytic (GO:0000738)3.74272254
36regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.72469989
37somatic hypermutation of immunoglobulin genes (GO:0016446)3.72417707
38somatic diversification of immune receptors via somatic mutation (GO:0002566)3.72417707
39protein localization to chromosome, centromeric region (GO:0071459)3.72038034
40kinetochore organization (GO:0051383)3.66840866
41negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.64536610
42negative regulation of ligase activity (GO:0051352)3.64536610
43nuclear envelope disassembly (GO:0051081)3.64134738
44membrane disassembly (GO:0030397)3.64134738
45telomere maintenance via telomere lengthening (GO:0010833)3.61618806
46mitotic chromosome condensation (GO:0007076)3.59585422
47regulation of helicase activity (GO:0051095)3.51836752
48establishment of chromosome localization (GO:0051303)3.51551449
49folic acid-containing compound biosynthetic process (GO:0009396)3.50994870
50DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.48291454
51IMP biosynthetic process (GO:0006188)3.47686966
52histone exchange (GO:0043486)3.47589129
53signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.46922786
54signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.46922786
55signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.46922786
56ribosome biogenesis (GO:0042254)3.46487831
57intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.46232697
58signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.46232697
59histone mRNA metabolic process (GO:0008334)3.45418650
60nucleotide-excision repair, DNA gap filling (GO:0006297)3.45181460
61kinetochore assembly (GO:0051382)3.44690900
62attachment of spindle microtubules to kinetochore (GO:0008608)3.43627236
63positive regulation of chromosome segregation (GO:0051984)3.38319656
64signal transduction involved in DNA damage checkpoint (GO:0072422)3.38239586
65signal transduction involved in DNA integrity checkpoint (GO:0072401)3.38239586
66establishment of protein localization to mitochondrial membrane (GO:0090151)3.37803913
67regulation of nuclear cell cycle DNA replication (GO:0033262)3.36696514
68signal transduction involved in cell cycle checkpoint (GO:0072395)3.36258710
69exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.36242821
70regulation of spindle organization (GO:0090224)3.35594935
71mitotic sister chromatid segregation (GO:0000070)3.32270397
72meiotic chromosome segregation (GO:0045132)3.30284299
73ribonucleoprotein complex biogenesis (GO:0022613)3.26755889
74nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.26755596
75mitotic sister chromatid cohesion (GO:0007064)3.26115405
76regulation of double-strand break repair via homologous recombination (GO:0010569)3.26068409
77positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.25361037
78ribosomal small subunit assembly (GO:0000028)3.24767538
79rRNA modification (GO:0000154)3.23539689
80ribosomal large subunit biogenesis (GO:0042273)3.23520231
81regulation of cellular amino acid metabolic process (GO:0006521)3.21950850
82non-recombinational repair (GO:0000726)3.20371602
83double-strand break repair via nonhomologous end joining (GO:0006303)3.20371602
84pseudouridine synthesis (GO:0001522)3.19659538
85deoxyribonucleotide biosynthetic process (GO:0009263)3.18820967
86regulation of gene silencing by RNA (GO:0060966)3.18245214
87regulation of posttranscriptional gene silencing (GO:0060147)3.18245214
88regulation of gene silencing by miRNA (GO:0060964)3.18245214
89positive regulation of ligase activity (GO:0051351)3.16234211
90IMP metabolic process (GO:0046040)3.15672384
91chromatin assembly or disassembly (GO:0006333)3.13756015
92regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.12969583
93mismatch repair (GO:0006298)3.12273424
94pore complex assembly (GO:0046931)3.12228913
95rRNA processing (GO:0006364)3.11239032
96DNA duplex unwinding (GO:0032508)3.10009920
97protein K6-linked ubiquitination (GO:0085020)3.09825663
98DNA geometric change (GO:0032392)3.08631469
99replication fork processing (GO:0031297)3.08383737
100regulation of mitotic spindle organization (GO:0060236)3.08369241
101folic acid metabolic process (GO:0046655)3.07793429
102maturation of 5.8S rRNA (GO:0000460)3.06053556
103spindle checkpoint (GO:0031577)3.05065504
104regulation of centrosome cycle (GO:0046605)3.03867309
105cullin deneddylation (GO:0010388)3.03396761
106rRNA metabolic process (GO:0016072)3.01376530
107DNA deamination (GO:0045006)3.00951375
108G1/S transition of mitotic cell cycle (GO:0000082)2.99463326
109cell cycle G1/S phase transition (GO:0044843)2.99463326
110sister chromatid segregation (GO:0000819)2.98472926
111transcription-coupled nucleotide-excision repair (GO:0006283)2.97771011
112regulation of chromosome segregation (GO:0051983)2.97675969
113negative regulation of chromosome segregation (GO:0051985)2.96650549
114DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.96186584
115protein localization to chromosome (GO:0034502)2.96083191
116somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.95605655
117isotype switching (GO:0045190)2.95605655
118somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.95605655
119establishment of viral latency (GO:0019043)2.95274684
120regulation of histone H3-K9 methylation (GO:0051570)2.94843641
121telomere organization (GO:0032200)2.94387763
122double-strand break repair via homologous recombination (GO:0000724)2.94185977
123recombinational repair (GO:0000725)2.94104742
124mitotic spindle checkpoint (GO:0071174)2.93810660
125maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.93799911
126telomere maintenance (GO:0000723)2.93191522
127regulation of mitotic metaphase/anaphase transition (GO:0030071)2.92602079
128negative regulation of mitotic sister chromatid separation (GO:2000816)2.91516225
129negative regulation of mitotic sister chromatid segregation (GO:0033048)2.91516225
130negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.91516225
131negative regulation of sister chromatid segregation (GO:0033046)2.91516225
132regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.91311217
133regulation of mitotic spindle checkpoint (GO:1903504)2.91311217
134ribosomal small subunit biogenesis (GO:0042274)2.91163843
135negative regulation of DNA-dependent DNA replication (GO:2000104)2.91123620
136spliceosomal snRNP assembly (GO:0000387)2.90942111
137regulation of ubiquitin-protein transferase activity (GO:0051438)2.90748249
138regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.90003375
139positive regulation of mitotic sister chromatid separation (GO:1901970)2.88725578
140positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.88725578
141positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.88725578
142ATP-dependent chromatin remodeling (GO:0043044)2.88185446
143negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.88185134
144regulation of sister chromatid cohesion (GO:0007063)2.87610155
145regulation of centriole replication (GO:0046599)2.87060097
146spindle assembly checkpoint (GO:0071173)2.85694069
147regulation of ligase activity (GO:0051340)2.84603603
148mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.83316128
149RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.83120833
150mitochondrial DNA replication (GO:0006264)2.82789134
151chaperone-mediated protein transport (GO:0072321)2.82383412

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.31420216
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.11517061
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.01264793
4* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.76802558
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.18782415
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.03904498
7* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.93165727
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.75550500
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.72931833
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.66905796
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.54121662
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.51452238
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.45688891
14* ETS1_20019798_ChIP-Seq_JURKAT_Human2.44572309
15* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.34373809
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.33776556
17AR_21909140_ChIP-Seq_LNCAP_Human2.17202016
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.16491932
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.13197768
20* VDR_23849224_ChIP-Seq_CD4+_Human2.11315431
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.08865105
22* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.00068971
23* XRN2_22483619_ChIP-Seq_HELA_Human1.99966906
24* E2F1_21310950_ChIP-Seq_MCF-7_Human1.98259104
25NANOG_18555785_ChIP-Seq_MESCs_Mouse1.98094395
26* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.94994777
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.90866730
28MYCN_18555785_ChIP-Seq_MESCs_Mouse1.89122094
29* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.86980312
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.84737595
31* FOXP3_21729870_ChIP-Seq_TREG_Human1.81408504
32FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.77256529
33SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.74630520
34DCP1A_22483619_ChIP-Seq_HELA_Human1.72149784
35POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.68869159
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.67813630
37ELF1_17652178_ChIP-ChIP_JURKAT_Human1.67103156
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.64934952
39* GABP_19822575_ChIP-Seq_HepG2_Human1.62809968
40KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.61818298
41KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.61818298
42KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.61818298
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60672807
44TTF2_22483619_ChIP-Seq_HELA_Human1.60013651
45ELK1_19687146_ChIP-ChIP_HELA_Human1.52668414
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.52284660
47CIITA_25753668_ChIP-Seq_RAJI_Human1.49500722
48MYC_22102868_ChIP-Seq_BL_Human1.48301413
49SALL1_21062744_ChIP-ChIP_HESCs_Human1.46327327
50HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.46255536
51STAT3_1855785_ChIP-Seq_MESCs_Mouse1.46152009
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42183301
53FLI1_27457419_Chip-Seq_LIVER_Mouse1.41982044
54POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.40962559
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.40175360
56THAP11_20581084_ChIP-Seq_MESCs_Mouse1.39819832
57* KDM5A_27292631_Chip-Seq_BREAST_Human1.37079153
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.36845210
59ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35533501
60* E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.35246655
61TP63_19390658_ChIP-ChIP_HaCaT_Human1.32870913
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.32505549
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.31836548
64ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31649148
65SOX2_18555785_ChIP-Seq_MESCs_Mouse1.28365245
66EWS_26573619_Chip-Seq_HEK293_Human1.28074026
67NOTCH1_21737748_ChIP-Seq_TLL_Human1.26712338
68PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.25727786
69NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.24332470
70FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.24016849
71SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.22854069
72* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.22504000
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20687773
74KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19100058
75SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.17572114
76NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.15734943
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15714315
78VDR_22108803_ChIP-Seq_LS180_Human1.15212260
79* SRF_21415370_ChIP-Seq_HL-1_Mouse1.14666541
80IRF1_19129219_ChIP-ChIP_H3396_Human1.12571560
81TFEB_21752829_ChIP-Seq_HELA_Human1.12382653
82PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11628752
83FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.10653413
84ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09626929
85* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07643084
86HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.05649495
87* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04480838
88CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.03949425
89* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02950574
90IRF8_21731497_ChIP-ChIP_J774_Mouse1.00438698
91CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.99540836
92KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99298174
93KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99248277
94* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.97860047
95* SPI1_23547873_ChIP-Seq_NB4_Human0.97537350
96NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.97305544
97DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96344785
98PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95740258
99MYB_26560356_Chip-Seq_TH2_Human0.95037143
100IRF8_22096565_ChIP-ChIP_GC-B_Human0.94755663
101FUS_26573619_Chip-Seq_HEK293_Human0.92945169
102* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.91190237
103* MYC_18940864_ChIP-ChIP_HL60_Human0.89546668
104* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.88770816
105CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.88663482
106NANOG_21062744_ChIP-ChIP_HESCs_Human0.88263882
107ELK1_22589737_ChIP-Seq_MCF10A_Human0.87753457
108POU3F2_20337985_ChIP-ChIP_501MEL_Human0.85276123
109CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.84939657
110BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.84936557
111* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.84521273
112ELF5_23300383_ChIP-Seq_T47D_Human0.84210403
113IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.83884312
114ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.83714435
115SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.82933841
116* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.82423113
117CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.82350150
118PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.82150069
119DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.79656250
120GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79541696
121SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.79212205
122GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.79186110
123STAT4_19710469_ChIP-ChIP_TH1__Mouse0.77665540
124CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.77227542
125NANOG_16153702_ChIP-ChIP_HESCs_Human0.74932313
126MYB_26560356_Chip-Seq_TH1_Human0.73983339
127IGF1R_20145208_ChIP-Seq_DFB_Human0.73229043
128NFE2_27457419_Chip-Seq_LIVER_Mouse0.69765786

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.16989723
2MP0010094_abnormal_chromosome_stability4.72422678
3MP0008057_abnormal_DNA_replication4.62050604
4MP0003111_abnormal_nucleus_morphology4.35616045
5MP0004957_abnormal_blastocyst_morpholog4.22557614
6MP0003077_abnormal_cell_cycle4.02124193
7MP0008058_abnormal_DNA_repair3.42363991
8MP0010352_gastrointestinal_tract_polyps2.69975843
9MP0008007_abnormal_cellular_replicative2.65985705
10MP0002396_abnormal_hematopoietic_system2.56045692
11MP0008932_abnormal_embryonic_tissue2.41725262
12MP0002163_abnormal_gland_morphology2.30633548
13MP0000350_abnormal_cell_proliferation2.24819276
14MP0001730_embryonic_growth_arrest2.20702861
15MP0003786_premature_aging2.10265714
16MP0003123_paternal_imprinting2.02808311
17MP0008877_abnormal_DNA_methylation1.98660208
18MP0010307_abnormal_tumor_latency1.96490479
19MP0003718_maternal_effect1.96145072
20MP0009697_abnormal_copulation1.91786636
21MP0005379_endocrine/exocrine_gland_phen1.86090204
22MP0000490_abnormal_crypts_of1.83187293
23MP0003950_abnormal_plasma_membrane1.82234442
24MP0005387_immune_system_phenotype1.67011945
25MP0001790_abnormal_immune_system1.67011945
26MP0005380_embryogenesis_phenotype1.66647947
27MP0001672_abnormal_embryogenesis/_devel1.66647947
28MP0003806_abnormal_nucleotide_metabolis1.65886891
29MP0001697_abnormal_embryo_size1.61334588
30MP0002019_abnormal_tumor_incidence1.54260000
31MP0006035_abnormal_mitochondrial_morpho1.45554434
32MP0002085_abnormal_embryonic_tissue1.44825293
33MP0006292_abnormal_olfactory_placode1.44801898
34MP0003984_embryonic_growth_retardation1.44760766
35MP0002080_prenatal_lethality1.44209678
36MP0002088_abnormal_embryonic_growth/wei1.41456252
37MP0006036_abnormal_mitochondrial_physio1.41321921
38MP0002086_abnormal_extraembryonic_tissu1.40979034
39MP0003763_abnormal_thymus_physiology1.40445157
40MP0000313_abnormal_cell_death1.39290067
41MP0000372_irregular_coat_pigmentation1.39107662
42MP0002084_abnormal_developmental_patter1.39053774
43MP0005310_abnormal_salivary_gland1.38783379
44MP0009333_abnormal_splenocyte_physiolog1.35589666
45MP0009785_altered_susceptibility_to1.32089390
46MP0004197_abnormal_fetal_growth/weight/1.30305836
47MP0002210_abnormal_sex_determination1.27404763
48MP0002398_abnormal_bone_marrow1.26764179
49MP0005075_abnormal_melanosome_morpholog1.25739958
50MP0004808_abnormal_hematopoietic_stem1.21376547
51MP0000703_abnormal_thymus_morphology1.18925108
52MP0000427_abnormal_hair_cycle1.18832377
53MP0005076_abnormal_cell_differentiation1.18342235
54MP0000858_altered_metastatic_potential1.17404036
55MP0001873_stomach_inflammation1.16413171
56MP0002722_abnormal_immune_system1.16093546
57MP0000689_abnormal_spleen_morphology1.16067134
58MP0001145_abnormal_male_reproductive1.14803412
59MP0002148_abnormal_hypersensitivity_rea1.14433070
60MP0003121_genomic_imprinting1.10619178
61MP0003890_abnormal_embryonic-extraembry1.10172300
62MP0001800_abnormal_humoral_immune1.09132459
63MP0005397_hematopoietic_system_phenotyp1.07965100
64MP0001545_abnormal_hematopoietic_system1.07965100
65MP0001835_abnormal_antigen_presentation1.07789683
66MP0003136_yellow_coat_color1.07727395
67MP0002938_white_spotting1.05128451
68MP0002102_abnormal_ear_morphology1.04572377
69MP0001929_abnormal_gametogenesis1.03477292
70MP0003941_abnormal_skin_development1.03053232
71MP0002877_abnormal_melanocyte_morpholog1.02743440
72MP0001764_abnormal_homeostasis1.00890335
73MP0000653_abnormal_sex_gland1.00732517
74MP0001293_anophthalmia0.99419487
75MP0000685_abnormal_immune_system0.98021499
76* MP0002429_abnormal_blood_cell0.97303157
77MP0002132_abnormal_respiratory_system0.96521740
78MP0003567_abnormal_fetal_cardiomyocyte0.95238734
79MP0003315_abnormal_perineum_morphology0.94598924
80MP0000716_abnormal_immune_system0.94209994
81MP0008872_abnormal_physiological_respon0.91780426
82MP0006072_abnormal_retinal_apoptosis0.91439586
83MP0005671_abnormal_response_to0.91392678
84MP0001119_abnormal_female_reproductive0.91282860
85MP0003195_calcinosis0.90865388
86MP0003787_abnormal_imprinting0.90539582
87MP0002452_abnormal_antigen_presenting0.89327999
88MP0002006_tumorigenesis0.88347445
89MP0004133_heterotaxia0.86803860
90MP0005023_abnormal_wound_healing0.86322756
91MP0003448_altered_tumor_morphology0.85809283
92MP0003221_abnormal_cardiomyocyte_apopto0.84823033
93MP0002420_abnormal_adaptive_immunity0.83920751
94MP0001819_abnormal_immune_cell0.82991451
95MP0002095_abnormal_skin_pigmentation0.80184517
96MP0003186_abnormal_redox_activity0.79480232
97MP0008789_abnormal_olfactory_epithelium0.77732724
98MP0000383_abnormal_hair_follicle0.77641893
99MP0002723_abnormal_immune_serum0.77236571
100MP0002277_abnormal_respiratory_mucosa0.75593050
101MP0005621_abnormal_cell_physiology0.75465127
102MP0002405_respiratory_system_inflammati0.72610493
103MP0001346_abnormal_lacrimal_gland0.72047168
104MP0005384_cellular_phenotype0.71941922
105MP0005084_abnormal_gallbladder_morpholo0.71744855
106MP0004264_abnormal_extraembryonic_tissu0.71568794
107MP0000477_abnormal_intestine_morphology0.70554157
108MP0002653_abnormal_ependyma_morphology0.69497803
109MP0008995_early_reproductive_senescence0.68353677
110MP0001881_abnormal_mammary_gland0.68028203
111MP0001915_intracranial_hemorrhage0.67818667
112MP0001853_heart_inflammation0.66687646
113MP0010155_abnormal_intestine_physiology0.66648912
114MP0002009_preneoplasia0.66351769
115MP0005395_other_phenotype0.65985828
116MP0002166_altered_tumor_susceptibility0.65603835
117MP0009765_abnormal_xenobiotic_induced0.65505249
118MP0003943_abnormal_hepatobiliary_system0.65343340
119MP0010678_abnormal_skin_adnexa0.65103419
120MP0004215_abnormal_myocardial_fiber0.64156606
121MP0010030_abnormal_orbit_morphology0.64007943
122MP0004147_increased_porphyrin_level0.63518332
123MP0002111_abnormal_tail_morphology0.63018715
124MP0005408_hypopigmentation0.62657905
125MP0002160_abnormal_reproductive_system0.62341534
126MP0000358_abnormal_cell_content/0.61673394
127MP0003566_abnormal_cell_adhesion0.61176041
128MP0005266_abnormal_metabolism0.61112660
129MP0003699_abnormal_female_reproductive0.60341974
130MP0005000_abnormal_immune_tolerance0.59868339
131MP0001286_abnormal_eye_development0.59505331
132MP0005389_reproductive_system_phenotype0.57965014
133MP0009672_abnormal_birth_weight0.57762265
134MP0002092_abnormal_eye_morphology0.56754547
135MP0003119_abnormal_digestive_system0.56197721
136MP0003937_abnormal_limbs/digits/tail_de0.56002479
137MP0005025_abnormal_response_to0.55903674

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.55608569
2Breast hypoplasia (HP:0003187)4.66838608
3Chromsome breakage (HP:0040012)4.40718928
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.17180913
5Colon cancer (HP:0003003)3.72241192
6Ependymoma (HP:0002888)3.64824348
7Agnosia (HP:0010524)3.63936998
8Reticulocytopenia (HP:0001896)3.63809147
9Medulloblastoma (HP:0002885)3.61690825
10Abnormality of chromosome stability (HP:0003220)3.38003705
11Patellar aplasia (HP:0006443)3.37085650
123-Methylglutaconic aciduria (HP:0003535)3.20255430
13Meckel diverticulum (HP:0002245)3.16569763
14Aplasia/Hypoplasia of the patella (HP:0006498)3.12798290
15Abnormality of the preputium (HP:0100587)3.11611888
16Oral leukoplakia (HP:0002745)3.06939281
17Acute necrotizing encephalopathy (HP:0006965)3.06298521
18Carpal bone hypoplasia (HP:0001498)3.05634614
19Abnormality of the ileum (HP:0001549)3.02319948
20Rhabdomyosarcoma (HP:0002859)3.00062467
21Absent radius (HP:0003974)2.98550876
22Abnormality of the labia minora (HP:0012880)2.97576096
23Increased CSF lactate (HP:0002490)2.96824770
24Abnormality of cells of the erythroid lineage (HP:0012130)2.95612783
25Absent thumb (HP:0009777)2.95036731
26Impulsivity (HP:0100710)2.94218739
27Aplasia/Hypoplasia of the uvula (HP:0010293)2.94019067
28Rough bone trabeculation (HP:0100670)2.83567665
29Selective tooth agenesis (HP:0001592)2.81781087
30Abnormal mitochondria in muscle tissue (HP:0008316)2.80918483
31Abnormality of the pons (HP:0007361)2.80419930
32Mitochondrial inheritance (HP:0001427)2.76627947
33Myelodysplasia (HP:0002863)2.75413916
34Absent forearm bone (HP:0003953)2.75343876
35Aplasia involving forearm bones (HP:0009822)2.75343876
36Acute encephalopathy (HP:0006846)2.71259713
37Aplastic anemia (HP:0001915)2.71115591
38Abnormal number of erythroid precursors (HP:0012131)2.70492783
39Supernumerary spleens (HP:0009799)2.69494692
40Increased hepatocellular lipid droplets (HP:0006565)2.69399232
41Abnormality of the anterior horn cell (HP:0006802)2.68628599
42Degeneration of anterior horn cells (HP:0002398)2.68628599
43Progressive macrocephaly (HP:0004481)2.64129935
44Lipid accumulation in hepatocytes (HP:0006561)2.62977671
45Bone marrow hypocellularity (HP:0005528)2.60572583
46Small intestinal stenosis (HP:0012848)2.60484885
47Duodenal stenosis (HP:0100867)2.60484885
48IgG deficiency (HP:0004315)2.59400268
49Increased serum lactate (HP:0002151)2.57522541
50Basal cell carcinoma (HP:0002671)2.56824524
51Neoplasm of the oral cavity (HP:0100649)2.55335840
52Amaurosis fugax (HP:0100576)2.47929356
53Exertional dyspnea (HP:0002875)2.45826029
54Cerebral hypomyelination (HP:0006808)2.40089027
55Premature ovarian failure (HP:0008209)2.39959232
56Neoplasm of the pancreas (HP:0002894)2.39241631
57Abnormality of T cell physiology (HP:0011840)2.38168389
58Gastrointestinal stroma tumor (HP:0100723)2.37655071
59Sloping forehead (HP:0000340)2.34781805
60Hepatocellular necrosis (HP:0001404)2.34083064
61Duplicated collecting system (HP:0000081)2.33843635
62Facial hemangioma (HP:0000329)2.33503880
63Premature graying of hair (HP:0002216)2.32960569
64B lymphocytopenia (HP:0010976)2.31931708
65Ectopic kidney (HP:0000086)2.31101292
66Abnormal lung lobation (HP:0002101)2.28104344
67IgA deficiency (HP:0002720)2.27336019
68Squamous cell carcinoma (HP:0002860)2.25611519
69Severe combined immunodeficiency (HP:0004430)2.25310166
70Volvulus (HP:0002580)2.24339006
71Abnormality of T cells (HP:0002843)2.22731828
72Overlapping toe (HP:0001845)2.20439351
73Macrocytic anemia (HP:0001972)2.20259545
74Combined immunodeficiency (HP:0005387)2.19940551
75Biliary tract neoplasm (HP:0100574)2.19409758
76IgM deficiency (HP:0002850)2.18993304
77Horseshoe kidney (HP:0000085)2.18902516
78Tracheoesophageal fistula (HP:0002575)2.18836227
79Pallor (HP:0000980)2.18453473
80Abnormality of methionine metabolism (HP:0010901)2.18392411
81Lymphoma (HP:0002665)2.18390556
82Abnormality of the duodenum (HP:0002246)2.16855771
83Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.15870642
84Lymphopenia (HP:0001888)2.15461166
85Hepatic necrosis (HP:0002605)2.15192895
86Cerebral edema (HP:0002181)2.15129934
87Hypoplasia of the pons (HP:0012110)2.14214463
88Neoplasm of striated muscle (HP:0009728)2.13902635
89Proximal placement of thumb (HP:0009623)2.13491306
90Abnormality of B cell number (HP:0010975)2.12852148
91Abnormal trabecular bone morphology (HP:0100671)2.11768320
92Panhypogammaglobulinemia (HP:0003139)2.10391153
93Clubbing of toes (HP:0100760)2.09950212
94Abnormality of T cell number (HP:0011839)2.09842545
95Decreased activity of mitochondrial respiratory chain (HP:0008972)2.09807773
96Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.09807773
97Aplasia/hypoplasia of the humerus (HP:0006507)2.09794378
98Abnormal delayed hypersensitivity skin test (HP:0002963)2.09759216
99Microretrognathia (HP:0000308)2.09503224
10011 pairs of ribs (HP:0000878)2.09269221
101Astrocytoma (HP:0009592)2.09143482
102Abnormality of the astrocytes (HP:0100707)2.09143482
103T lymphocytopenia (HP:0005403)2.08057910
104Recurrent viral infections (HP:0004429)2.08030568
105Renal cortical cysts (HP:0000803)2.07410900
106Rib fusion (HP:0000902)2.05156331
107Atresia of the external auditory canal (HP:0000413)2.04912019
108Short thumb (HP:0009778)2.04585513
109Cellular immunodeficiency (HP:0005374)2.04106375
110Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.02495123
111Deviation of the thumb (HP:0009603)2.02337361
112Abnormality of cells of the lymphoid lineage (HP:0012140)2.01208189
113Abnormality of the carotid arteries (HP:0005344)1.99641827
114Abnormality of the renal collecting system (HP:0004742)1.98813787
115Prominent nose (HP:0000448)1.97931577
116Glioma (HP:0009733)1.97447424
117Cleft eyelid (HP:0000625)1.97395805
118Pancreatic cysts (HP:0001737)1.97196698
119Abnormality of lateral ventricle (HP:0030047)1.96922831
120Triphalangeal thumb (HP:0001199)1.96465767
121Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.95871940
122Abnormality of alanine metabolism (HP:0010916)1.95871940
123Hyperalaninemia (HP:0003348)1.95871940
124Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.95460705
125Increased serum pyruvate (HP:0003542)1.94396175
126Shawl scrotum (HP:0000049)1.94394821
127Neoplasm of the colon (HP:0100273)1.93466770
128Ureteral duplication (HP:0000073)1.92916923
129Increased nuchal translucency (HP:0010880)1.92790788
130Abnormal number of incisors (HP:0011064)1.92756202
131Abnormality of glycolysis (HP:0004366)1.91752798
132Lactic acidosis (HP:0003128)1.90047034
133Cafe-au-lait spot (HP:0000957)1.89470875
134Type I transferrin isoform profile (HP:0003642)1.88819794
135Abnormality of aspartate family amino acid metabolism (HP:0010899)1.88215587
136Abnormality of DNA repair (HP:0003254)1.88194815
137Exercise intolerance (HP:0003546)1.87969558
138Asplenia (HP:0001746)1.87859551
139Supernumerary bones of the axial skeleton (HP:0009144)1.87515960
140Nephroblastoma (Wilms tumor) (HP:0002667)1.87051155
141Missing ribs (HP:0000921)1.85079087
142Secondary amenorrhea (HP:0000869)1.83336095
143Trismus (HP:0000211)1.82567671
144Autoimmune hemolytic anemia (HP:0001890)1.81069256
145Renal Fanconi syndrome (HP:0001994)1.80997870
146Embryonal renal neoplasm (HP:0011794)1.80375916
147Leukopenia (HP:0001882)1.80046635
148Recurrent cutaneous fungal infections (HP:0011370)1.80035508
149Chronic mucocutaneous candidiasis (HP:0002728)1.80035508
150Reduced antithrombin III activity (HP:0001976)1.78634789
151Multiple enchondromatosis (HP:0005701)1.78399678
152Hypoplasia of the radius (HP:0002984)1.77709832
153Stenosis of the external auditory canal (HP:0000402)1.76314448
154Pancytopenia (HP:0001876)1.75823815
155Abnormality of placental membranes (HP:0011409)1.75539476
156Amniotic constriction ring (HP:0009775)1.75539476
157Aplasia/Hypoplasia of the spleen (HP:0010451)1.74999884
158Acute hepatic failure (HP:0006554)1.74505596
159Type II lissencephaly (HP:0007260)1.74064667
160Respiratory difficulties (HP:0002880)1.73775694

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.16686662
2CDC74.13983153
3BUB14.03428024
4VRK23.27901084
5PLK42.77538095
6TTK2.67756536
7NEK22.63982070
8EIF2AK12.50677721
9SRPK12.49769752
10ACVR1B2.46445301
11CDK122.15250885
12NUAK12.07680609
13PLK12.06828834
14TRIM282.02659147
15CDK192.00786755
16BRSK21.98739927
17TSSK61.94541430
18NME21.84458766
19DYRK31.84098069
20EPHA21.81388289
21STK101.80945438
22TAF11.80853370
23CDK71.79588743
24NEK11.77834402
25TLK11.71533171
26ATR1.69512760
27RPS6KB21.69105235
28EIF2AK31.67312887
29PDK21.64833892
30MKNK11.63856270
31STK161.61969881
32PLK31.61302015
33AURKB1.60300136
34CHEK21.55350851
35NME11.53361533
36CDK41.49083556
37RPS6KA41.46598180
38VRK11.43566093
39MKNK21.34351120
40MAP3K81.32721415
41STK41.32705916
42TESK21.31167020
43CHEK11.26787994
44MAP4K11.26689397
45MAP3K101.26524553
46ERBB31.18770889
47PASK1.16428434
48PIM11.14381157
49SIK31.11128446
50AURKA1.09165149
51MELK1.07353067
52MAP3K121.04373025
53TGFBR10.98813680
54ATM0.97158509
55MAP3K140.96090813
56BMPR1B0.93374156
57BRSK10.90939447
58ZAK0.88439241
59EEF2K0.88141747
60TRPM70.87185342
61CDK20.86234612
62BCR0.83871914
63PAK40.83666857
64ALK0.83533793
65CCNB10.83420530
66EIF2AK20.75348362
67BRD40.75038404
68CDK60.74037009
69PBK0.73049048
70PNCK0.72712451
71FLT30.72272562
72STK38L0.70402538
73STK30.68905238
74PIM20.67500748
75MAP2K30.65288128
76CSNK2A20.65117561
77TNIK0.64466829
78CDK80.64070905
79MAPKAPK30.63303342
80TEC0.63243575
81PRKCI0.61926838
82CSNK2A10.61153450
83OXSR10.60896322
84IKBKB0.59557471
85BRAF0.59372494
86CDK10.58416170
87FRK0.55620455
88SCYL20.54526226
89IRAK40.54440157
90PAK10.53774236
91ERBB40.53421044
92STK390.53107704
93BMPR20.52021849
94TYK20.51597943
95KDR0.51168919
96RPS6KA50.50390514
97ZAP700.48993781
98JAK30.47262566
99WNK30.44819857
100PRKCQ0.44186836
101PLK20.43693702
102INSRR0.43604163
103LATS10.43397633
104CDK90.42477291
105LATS20.41707785
106CSNK1G10.41371142
107CLK10.41335110
108BTK0.41256018
109MST40.40767649
110ITK0.40101554
111CHUK0.39093861
112NLK0.38951704
113CSF1R0.38772307
114BLK0.37901792
115AKT30.35208690
116GRK60.34386007
117ADRBK20.34382834
118TXK0.34228590
119MAP3K50.34068882
120RAF10.33784102
121FGFR10.33521381
122MTOR0.32427680
123MOS0.31646302
124MAP2K60.31388262
125CAMKK20.30937610
126DAPK10.30835582
127MARK30.30073917
128PRKDC0.29573616
129CSNK1E0.29436873
130WNK40.27319374
131MAP3K130.23714010
132CSNK1G30.23305589
133MAPK110.22315136

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.82563989
2Mismatch repair_Homo sapiens_hsa034304.42995756
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.83833605
4RNA transport_Homo sapiens_hsa030133.13204001
5RNA polymerase_Homo sapiens_hsa030203.10183223
6Spliceosome_Homo sapiens_hsa030403.09308758
7Homologous recombination_Homo sapiens_hsa034403.06193951
8Base excision repair_Homo sapiens_hsa034103.04403068
9Proteasome_Homo sapiens_hsa030502.92637044
10Protein export_Homo sapiens_hsa030602.88824935
11Nucleotide excision repair_Homo sapiens_hsa034202.83419960
12Ribosome_Homo sapiens_hsa030102.82215165
13Cell cycle_Homo sapiens_hsa041102.77362359
14One carbon pool by folate_Homo sapiens_hsa006702.58556918
15Non-homologous end-joining_Homo sapiens_hsa034502.49849169
16Fanconi anemia pathway_Homo sapiens_hsa034602.30831697
17Pyrimidine metabolism_Homo sapiens_hsa002402.28768835
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.25529143
19Basal transcription factors_Homo sapiens_hsa030222.20323260
20Oxidative phosphorylation_Homo sapiens_hsa001902.04763774
21RNA degradation_Homo sapiens_hsa030182.01697134
22Parkinsons disease_Homo sapiens_hsa050121.76361313
23p53 signaling pathway_Homo sapiens_hsa041151.74715975
24mRNA surveillance pathway_Homo sapiens_hsa030151.65592202
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.35547980
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.33398903
27Huntingtons disease_Homo sapiens_hsa050161.31903904
28Epstein-Barr virus infection_Homo sapiens_hsa051691.27095319
29Purine metabolism_Homo sapiens_hsa002301.17939620
30Antigen processing and presentation_Homo sapiens_hsa046121.16163700
31Herpes simplex infection_Homo sapiens_hsa051681.15795360
32Type I diabetes mellitus_Homo sapiens_hsa049401.13036227
33Primary immunodeficiency_Homo sapiens_hsa053401.10477156
34Propanoate metabolism_Homo sapiens_hsa006401.06357125
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.03352035
36Systemic lupus erythematosus_Homo sapiens_hsa053221.01252728
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.97579529
38Alzheimers disease_Homo sapiens_hsa050100.97546574
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.97484497
40Viral carcinogenesis_Homo sapiens_hsa052030.97402968
41Folate biosynthesis_Homo sapiens_hsa007900.89135050
42Vitamin B6 metabolism_Homo sapiens_hsa007500.86548015
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.86207153
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81005464
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80932818
46NF-kappa B signaling pathway_Homo sapiens_hsa040640.79381805
47Pyruvate metabolism_Homo sapiens_hsa006200.78395602
48Oocyte meiosis_Homo sapiens_hsa041140.76952588
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.76751919
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76491259
51Pentose phosphate pathway_Homo sapiens_hsa000300.73886088
52HTLV-I infection_Homo sapiens_hsa051660.73277924
53Selenocompound metabolism_Homo sapiens_hsa004500.72395196
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70213254
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68781010
56Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67456274
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.66019401
58Measles_Homo sapiens_hsa051620.63362394
59Sulfur relay system_Homo sapiens_hsa041220.62511515
60MicroRNAs in cancer_Homo sapiens_hsa052060.61802675
61Steroid biosynthesis_Homo sapiens_hsa001000.61535516
62Legionellosis_Homo sapiens_hsa051340.60682883
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.60408870
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59967836
65N-Glycan biosynthesis_Homo sapiens_hsa005100.59022857
66Small cell lung cancer_Homo sapiens_hsa052220.57717200
67Intestinal immune network for IgA production_Homo sapiens_hsa046720.57606289
68Biosynthesis of amino acids_Homo sapiens_hsa012300.57126887
69Apoptosis_Homo sapiens_hsa042100.54767601
70Thyroid cancer_Homo sapiens_hsa052160.54730842
71NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54697484
72RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53548992
73Fatty acid elongation_Homo sapiens_hsa000620.53217117
742-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.51269905
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.50504847
76Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50140564
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47491882
78TGF-beta signaling pathway_Homo sapiens_hsa043500.46602493
79Glutathione metabolism_Homo sapiens_hsa004800.44808108
80Allograft rejection_Homo sapiens_hsa053300.44329040
81Graft-versus-host disease_Homo sapiens_hsa053320.43551267
82Hematopoietic cell lineage_Homo sapiens_hsa046400.43111694
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40995264
84Hepatitis B_Homo sapiens_hsa051610.39655813
85Influenza A_Homo sapiens_hsa051640.38517343
86Colorectal cancer_Homo sapiens_hsa052100.37584356
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37163062
88Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.35576947
89Notch signaling pathway_Homo sapiens_hsa043300.35422452
90Renin-angiotensin system_Homo sapiens_hsa046140.35388593
91Shigellosis_Homo sapiens_hsa051310.32435675
92Hippo signaling pathway_Homo sapiens_hsa043900.32056733
93Fructose and mannose metabolism_Homo sapiens_hsa000510.28239921
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27571372
95Leishmaniasis_Homo sapiens_hsa051400.26864496
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.26443603
97Sulfur metabolism_Homo sapiens_hsa009200.26399809
98Autoimmune thyroid disease_Homo sapiens_hsa053200.23412351
99B cell receptor signaling pathway_Homo sapiens_hsa046620.22039755
100Chronic myeloid leukemia_Homo sapiens_hsa052200.20702611
101Regulation of autophagy_Homo sapiens_hsa041400.20607616
102T cell receptor signaling pathway_Homo sapiens_hsa046600.20479743
103Pathways in cancer_Homo sapiens_hsa052000.20475975
104Acute myeloid leukemia_Homo sapiens_hsa052210.18477872
105Viral myocarditis_Homo sapiens_hsa054160.18403183
106Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.17945876
107Rheumatoid arthritis_Homo sapiens_hsa053230.17752651
108Pancreatic cancer_Homo sapiens_hsa052120.17364552
109Linoleic acid metabolism_Homo sapiens_hsa005910.15202872
110Adherens junction_Homo sapiens_hsa045200.14748999
111Asthma_Homo sapiens_hsa053100.14645289
112Carbon metabolism_Homo sapiens_hsa012000.14545078
113FoxO signaling pathway_Homo sapiens_hsa040680.13981789
114Other glycan degradation_Homo sapiens_hsa005110.13815190
115Prostate cancer_Homo sapiens_hsa052150.13782220
116Peroxisome_Homo sapiens_hsa041460.13359571
117Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.13075008
118Arachidonic acid metabolism_Homo sapiens_hsa005900.12663077
119Alcoholism_Homo sapiens_hsa050340.12624277
120Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.11536252
121Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.11177956
122Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.10314010
123Basal cell carcinoma_Homo sapiens_hsa052170.10167065
124Metabolic pathways_Homo sapiens_hsa011000.10159832
125Galactose metabolism_Homo sapiens_hsa000520.09944673
126Phototransduction_Homo sapiens_hsa047440.09476154
127Butanoate metabolism_Homo sapiens_hsa006500.09063873
128Cardiac muscle contraction_Homo sapiens_hsa042600.06420696

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