EEA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.69569324
2regulation of calcineurin-NFAT signaling cascade (GO:0070884)4.23557304
3positive regulation by symbiont of host defense response (GO:0052509)4.06393590
4modulation by symbiont of host defense response (GO:0052031)4.06393590
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.06393590
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.06393590
7positive regulation by organism of defense response of other organism involved in symbiotic interact4.06393590
8modulation by symbiont of host immune response (GO:0052553)4.06393590
9protein targeting to Golgi (GO:0000042)3.91670918
10positive regulation of protein autophosphorylation (GO:0031954)3.70636592
11retrograde transport, vesicle recycling within Golgi (GO:0000301)3.63617650
12regulation of interferon-beta biosynthetic process (GO:0045357)3.50736933
13growth hormone receptor signaling pathway (GO:0060396)3.47809882
14positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.45811747
15sequestering of extracellular ligand from receptor (GO:0035581)3.41845578
16regulation of interleukin-12 biosynthetic process (GO:0045075)3.29966435
17neutrophil activation involved in immune response (GO:0002283)3.28511179
18cell adhesion mediated by integrin (GO:0033627)3.27496555
19positive regulation of p38MAPK cascade (GO:1900745)3.26032735
20positive regulation of heat generation (GO:0031652)3.19683429
21positive regulation of interferon-alpha production (GO:0032727)3.13659797
22smooth muscle tissue development (GO:0048745)3.13352609
23regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.07174594
24regulation of interferon-alpha production (GO:0032647)3.06463952
25regulation of membrane protein ectodomain proteolysis (GO:0051043)3.05742505
26collagen fibril organization (GO:0030199)3.04515724
27protein localization to Golgi apparatus (GO:0034067)3.03780850
28positive regulation of muscle hypertrophy (GO:0014742)2.97921802
29positive regulation of cardiac muscle hypertrophy (GO:0010613)2.97921802
30prostate gland growth (GO:0060736)2.97432482
31positive regulation of cellular amide metabolic process (GO:0034250)2.97175364
32JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.96895091
33positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.96459241
34positive regulation of gamma-delta T cell activation (GO:0046645)2.93943829
35cytoplasmic mRNA processing body assembly (GO:0033962)2.93159086
36macrophage activation involved in immune response (GO:0002281)2.91487517
37cellular response to growth hormone stimulus (GO:0071378)2.90000824
38macroautophagy (GO:0016236)2.89697049
39regulation of glucokinase activity (GO:0033131)2.88379779
40regulation of hexokinase activity (GO:1903299)2.88379779
41positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.88011763
42interkinetic nuclear migration (GO:0022027)2.87980390
43I-kappaB phosphorylation (GO:0007252)2.86903867
44Golgi to endosome transport (GO:0006895)2.78837189
45regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.78337017
46negative regulation of lipid storage (GO:0010888)2.77624865
47protein localization to endosome (GO:0036010)2.73977584
48positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.73030112
49regulation of mononuclear cell migration (GO:0071675)2.72035310
50UDP-N-acetylglucosamine metabolic process (GO:0006047)2.71474122
51COPII vesicle coating (GO:0048208)2.71370029
52positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.71031980
53regulation of Rac protein signal transduction (GO:0035020)2.69981616
54mesenchymal-epithelial cell signaling (GO:0060638)2.69947141
55negative regulation of hormone biosynthetic process (GO:0032353)2.69512608
56pericardium development (GO:0060039)2.68688060
57positive regulation of natural killer cell differentiation (GO:0032825)2.66712932
58positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.65903225
59regulation of DNA endoreduplication (GO:0032875)2.65864932
60natural killer cell mediated immunity (GO:0002228)2.65842603
61natural killer cell mediated cytotoxicity (GO:0042267)2.65842603
62regulation of fever generation (GO:0031620)2.65240890
63positive regulation of bone resorption (GO:0045780)2.65199358
64positive regulation of bone remodeling (GO:0046852)2.65199358
65regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.64295298
66negative regulation of protein localization to cell surface (GO:2000009)2.63396710
67chondrocyte proliferation (GO:0035988)2.62280608
68response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.59897488
69response to host immune response (GO:0052572)2.59897488
70protein localization to cell surface (GO:0034394)2.58605655
71apoptotic cell clearance (GO:0043277)2.58386569
72positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.56914009
73intra-Golgi vesicle-mediated transport (GO:0006891)2.56366014
74response to muramyl dipeptide (GO:0032495)2.56209561
75negative regulation of axon extension involved in axon guidance (GO:0048843)2.54778071
76modulation by symbiont of host cellular process (GO:0044068)2.54646270
77regulation of integrin-mediated signaling pathway (GO:2001044)2.53594940
78interleukin-6-mediated signaling pathway (GO:0070102)2.51733635
79protein prenylation (GO:0018342)2.50950971
80prenylation (GO:0097354)2.50950971
81blood vessel maturation (GO:0001955)2.50235949
82regulation of macrophage derived foam cell differentiation (GO:0010743)2.50176384
83positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.50133453
84regulation of cardiac muscle hypertrophy (GO:0010611)2.49115934
85regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.48471245
86regulation of sarcomere organization (GO:0060297)2.47627058
87keratinocyte development (GO:0003334)2.47078167
88regulation of muscle hypertrophy (GO:0014743)2.46179620
89regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.46142545
90metanephric mesenchyme development (GO:0072075)2.45637910
91negative regulation of complement activation (GO:0045916)2.44805865
92face morphogenesis (GO:0060325)2.43975124
93glomerular visceral epithelial cell development (GO:0072015)2.43910275
94wound healing, spreading of epidermal cells (GO:0035313)2.43540735
95regulation of establishment of cell polarity (GO:2000114)2.43515627
96lymphangiogenesis (GO:0001946)2.43467592
97artery development (GO:0060840)2.43265827
98monoubiquitinated protein deubiquitination (GO:0035520)2.43050463
99tyrosine phosphorylation of STAT protein (GO:0007260)2.41395905
100response to host (GO:0075136)2.39476387
101response to host defenses (GO:0052200)2.39476387
102response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.39476387
103hemidesmosome assembly (GO:0031581)2.39143762
104positive regulation of glycolytic process (GO:0045821)2.38798597
105retina vasculature morphogenesis in camera-type eye (GO:0061299)2.38706949
106phospholipid homeostasis (GO:0055091)2.37652162
107fibroblast migration (GO:0010761)2.36434928
108desmosome organization (GO:0002934)2.35633555
109response to peptidoglycan (GO:0032494)2.35483069
110positive regulation of humoral immune response (GO:0002922)2.31847795
111positive regulation of interferon-beta production (GO:0032728)2.31544405
112low-density lipoprotein particle clearance (GO:0034383)2.30885079
113substrate adhesion-dependent cell spreading (GO:0034446)2.30423998
114nucleus localization (GO:0051647)2.30231675
115genitalia morphogenesis (GO:0035112)2.29566272
116regulation of heat generation (GO:0031650)2.29528551
117regulation of type B pancreatic cell apoptotic process (GO:2000674)2.28604726
118kidney mesenchyme development (GO:0072074)2.27609570
119lipoprotein transport (GO:0042953)2.27300971
120lipopolysaccharide-mediated signaling pathway (GO:0031663)2.26908458
121regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.26358652
122regulation of cholesterol storage (GO:0010885)2.26063258
123mitotic sister chromatid cohesion (GO:0007064)2.25954284
124negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.25418179
125negative regulation of cell killing (GO:0031342)2.24863388
126negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.24863388
127negative regulation of hormone metabolic process (GO:0032351)2.24507332
128lipid translocation (GO:0034204)2.24227403
129phospholipid translocation (GO:0045332)2.24227403
130regulation of keratinocyte proliferation (GO:0010837)2.23254748
131positive regulation of macrophage differentiation (GO:0045651)2.22653620
132myeloid cell activation involved in immune response (GO:0002275)2.22441198
133negative regulation of protein activation cascade (GO:2000258)2.22111043
134positive regulation of lipid storage (GO:0010884)2.21550616
135regulation of protein glycosylation (GO:0060049)2.19315282
136regulation of protein polyubiquitination (GO:1902914)2.19117004
137granulocyte activation (GO:0036230)2.18958205
138glomerular basement membrane development (GO:0032836)2.18421290
139endocardial cushion development (GO:0003197)2.17752310
140microglial cell activation (GO:0001774)2.17525966
141positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.17276357
142platelet-derived growth factor receptor signaling pathway (GO:0048008)2.16401464
143regulation of axon extension involved in axon guidance (GO:0048841)2.16099514
144macrophage activation (GO:0042116)2.16038899
145modification by symbiont of host morphology or physiology (GO:0044003)2.15768111
146regulation of protein autophosphorylation (GO:0031952)2.15516990
147cellular response to interferon-alpha (GO:0035457)2.15322894
148cellular response to ethanol (GO:0071361)2.15305708
149regulation of muscle adaptation (GO:0043502)2.15151176
150interferon-gamma-mediated signaling pathway (GO:0060333)2.15095739
151detection of calcium ion (GO:0005513)2.15079285
152regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.14389654
153T-helper 1 type immune response (GO:0042088)2.14259178
154germinal center formation (GO:0002467)2.13654990
155response to redox state (GO:0051775)2.13511176
156lung lobe morphogenesis (GO:0060463)2.12730785
157regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.12622308
158regulation of establishment or maintenance of cell polarity (GO:0032878)2.12011071
159regulation of interleukin-8 biosynthetic process (GO:0045414)2.11529132
160positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.11304731
161positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.11304731
162positive regulation of mitotic sister chromatid separation (GO:1901970)2.11304731
163ovulation from ovarian follicle (GO:0001542)2.11299461
164regulation of integrin activation (GO:0033623)2.11292633
165positive regulation of fibroblast migration (GO:0010763)2.11233207
166anterior/posterior axis specification, embryo (GO:0008595)2.11037095
167positive regulation of chemokine biosynthetic process (GO:0045080)2.10758847
168vascular smooth muscle contraction (GO:0014829)2.10504604
169production of molecular mediator involved in inflammatory response (GO:0002532)2.09706203
170lipid particle organization (GO:0034389)2.09405398
171neutrophil mediated immunity (GO:0002446)2.09370330
172hydrogen peroxide biosynthetic process (GO:0050665)2.09184157
173hippo signaling (GO:0035329)2.08650515
174regulation of skeletal muscle contraction (GO:0014819)2.08518269
175response to pheromone (GO:0019236)2.07329664
176regulation of meiosis I (GO:0060631)2.06554221
177* early endosome to late endosome transport (GO:0045022)2.06301675
178keratan sulfate catabolic process (GO:0042340)2.06023412
179magnesium ion transport (GO:0015693)2.05097165
180regulation of transforming growth factor beta2 production (GO:0032909)2.05075749
181eye photoreceptor cell differentiation (GO:0001754)2.05024187
182photoreceptor cell differentiation (GO:0046530)2.05024187
183establishment of protein localization to vacuole (GO:0072666)2.04973941
184protein targeting to vacuole (GO:0006623)2.04973941
185myeloid dendritic cell differentiation (GO:0043011)2.04916212
186positive regulation of interleukin-1 production (GO:0032732)2.04807835
187JAK-STAT cascade (GO:0007259)2.03536734
188neutrophil activation (GO:0042119)2.03074671
189positive regulation of interleukin-12 production (GO:0032735)2.01195858
190positive regulation of interleukin-1 beta production (GO:0032731)2.01080048
191regulation of vitamin D biosynthetic process (GO:0060556)2.00098696
192cytokine secretion (GO:0050663)1.98855000
193detection of molecule of bacterial origin (GO:0032490)1.97339850
194plasma membrane repair (GO:0001778)1.97119314
195establishment of protein localization to Golgi (GO:0072600)1.95876066

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human3.40226551
2* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.18766850
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.93039659
4SALL1_21062744_ChIP-ChIP_HESCs_Human2.84659764
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.78700488
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.74894592
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.65745862
8SMAD_19615063_ChIP-ChIP_OVARY_Human2.61336089
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.53021421
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.51591441
11* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.28253477
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.27792348
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.23608148
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.19378436
15CDX2_19796622_ChIP-Seq_MESCs_Mouse2.18124750
16TP63_17297297_ChIP-ChIP_HaCaT_Human2.15793843
17* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.06770617
18* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.05743197
19FUS_26573619_Chip-Seq_HEK293_Human2.04586238
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.03098372
21TAF15_26573619_Chip-Seq_HEK293_Human2.00831854
22* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.98823493
23P300_19829295_ChIP-Seq_ESCs_Human1.91554044
24* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.87918052
25ZNF217_24962896_ChIP-Seq_MCF-7_Human1.84242543
26RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.81981872
27RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.80502160
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.77697869
29* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.71202540
30* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.71202540
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.69968293
32EWS_26573619_Chip-Seq_HEK293_Human1.67912436
33MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.67166609
34* TP53_16413492_ChIP-PET_HCT116_Human1.66369909
35VDR_24787735_ChIP-Seq_THP-1_Human1.60965099
36* EZH2_27294783_Chip-Seq_NPCs_Mouse1.60409820
37GATA2_21666600_ChIP-Seq_HMVEC_Human1.59662099
38FOXO3_23340844_ChIP-Seq_DLD1_Human1.59637282
39SMAD3_21741376_ChIP-Seq_EPCs_Human1.58697555
40SUZ12_27294783_Chip-Seq_NPCs_Mouse1.57612838
41SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.56456081
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.55183051
43NANOG_18555785_Chip-Seq_ESCs_Mouse1.55044324
44TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.54364778
45TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.51499479
46UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49830015
47ER_23166858_ChIP-Seq_MCF-7_Human1.49310132
48* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48634705
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.48086355
50LXR_22158963_ChIP-Seq_LIVER_Mouse1.47657097
51* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.47231146
52ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.46663710
53NR3C1_21868756_ChIP-Seq_MCF10A_Human1.46137858
54* CJUN_26792858_Chip-Seq_BT549_Human1.45799166
55* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.45324168
56TCF4_23295773_ChIP-Seq_U87_Human1.45314758
57EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.42781401
58VDR_22108803_ChIP-Seq_LS180_Human1.41290049
59PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40410851
60CBP_20019798_ChIP-Seq_JUKART_Human1.39249197
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39249197
62BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.38060974
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37690346
64BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.36549979
65E2F1_18555785_Chip-Seq_ESCs_Mouse1.35020365
66* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.34223283
67RXR_22108803_ChIP-Seq_LS180_Human1.33772493
68ZNF274_21170338_ChIP-Seq_K562_Hela1.33460791
69CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33347404
70* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.32278343
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32114819
72P53_22387025_ChIP-Seq_ESCs_Mouse1.31144721
73NFE2_27457419_Chip-Seq_LIVER_Mouse1.29216543
74RUNX_20019798_ChIP-Seq_JUKART_Human1.28067368
75GATA1_22025678_ChIP-Seq_K562_Human1.27048587
76EGR1_19374776_ChIP-ChIP_THP-1_Human1.26660848
77* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.26251855
78CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.26250901
79CMYC_18555785_Chip-Seq_ESCs_Mouse1.25747858
80TRIM28_21343339_ChIP-Seq_HEK293_Human1.24758445
81TP53_18474530_ChIP-ChIP_U2OS_Human1.24099710
82* FLI1_21867929_ChIP-Seq_TH2_Mouse1.24008844
83VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.23807927
84EP300_21415370_ChIP-Seq_HL-1_Mouse1.22685856
85SUZ12_18555785_Chip-Seq_ESCs_Mouse1.21652246
86PIAS1_25552417_ChIP-Seq_VCAP_Human1.21236387
87* CRX_20693478_ChIP-Seq_RETINA_Mouse1.20568762
88* PU_27001747_Chip-Seq_BMDM_Mouse1.19265751
89SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.18861723
90SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.18861723
91POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17987419
92MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.17238101
93NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.15806278
94AHR_22903824_ChIP-Seq_MCF-7_Human1.15708494
95TCF4_22108803_ChIP-Seq_LS180_Human1.15370159
96RXR_22158963_ChIP-Seq_LIVER_Mouse1.15207167
97HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.14233291
98STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.13802463
99* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.13473293
100FOXA2_19822575_ChIP-Seq_HepG2_Human1.12529210
101SOX2_20726797_ChIP-Seq_SW620_Human1.11965961
102TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11929084
103STAT3_18555785_Chip-Seq_ESCs_Mouse1.11833243
104* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11523047
105ESR1_21235772_ChIP-Seq_MCF-7_Human1.10957129
106* TP63_23658742_ChIP-Seq_EP156T_Human1.10857959
107ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.10126459
108SOX2_18555785_Chip-Seq_ESCs_Mouse1.09806218
109EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.08832089
110* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08821566
111SMAD4_21799915_ChIP-Seq_A2780_Human1.08311419
112* RUNX2_22187159_ChIP-Seq_PCA_Human1.08281417
113STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07925130
114FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07811714
115* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07732095
116IGF1R_20145208_ChIP-Seq_DFB_Human1.07402579
117ARNT_22903824_ChIP-Seq_MCF-7_Human1.07375287
118WT1_19549856_ChIP-ChIP_CCG9911_Human1.07232040
119ESR2_21235772_ChIP-Seq_MCF-7_Human1.07181134
120* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06760132
121SOX2_21211035_ChIP-Seq_LN229_Gbm1.06621245
122BRD4_25478319_ChIP-Seq_HGPS_Human1.06519892
123CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06062123
124P300_18555785_Chip-Seq_ESCs_Mouse1.05024182
125SOX9_24532713_ChIP-Seq_HFSC_Mouse1.04993144
126SPI1_23127762_ChIP-Seq_K562_Human1.04719703
127FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.04588471
128SMAD4_21741376_ChIP-Seq_EPCs_Human1.04541332
129ESR1_20079471_ChIP-ChIP_T-47D_Human1.03512995
130FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.03040121
131EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02885609
132OCT4_18555785_Chip-Seq_ESCs_Mouse1.02585924
133SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02560114
134IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.00896284
135* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.98965362
136* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97950627
137BCAT_22108803_ChIP-Seq_LS180_Human0.97430307
138BRD4_27068464_Chip-Seq_AML-cells_Mouse0.96848210
139JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96758167
140NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95997633
141JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95974705
142STAT3_23295773_ChIP-Seq_U87_Human0.94798340
143CLOCK_20551151_ChIP-Seq_293T_Human0.94388980
144PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90424746
145TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90041395
146TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88967832
147GBX2_23144817_ChIP-Seq_PC3_Human0.88957648
148* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.88836199
149TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88654766
150SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87939372
151CDX2_22108803_ChIP-Seq_LS180_Human0.87844318
152ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87549982
153TCF4_18268006_ChIP-ChIP_LS174T_Human0.87447109
154CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87436539
155* AR_25329375_ChIP-Seq_VCAP_Human0.86564624
156AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.85116793
157* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83265404
158SALL4_18804426_ChIP-ChIP_XEN_Mouse0.83030709

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.25749913
2MP0003300_gastrointestinal_ulcer3.53296330
3MP0003950_abnormal_plasma_membrane3.49217884
4MP0003303_peritoneal_inflammation3.04188672
5MP0005503_abnormal_tendon_morphology2.96441129
6MP0006054_spinal_hemorrhage2.82579288
7MP0003436_decreased_susceptibility_to2.67255246
8MP0004272_abnormal_basement_membrane2.50386788
9MP0002877_abnormal_melanocyte_morpholog2.47807920
10MP0001835_abnormal_antigen_presentation2.47787378
11MP0004510_myositis2.38453682
12MP0005058_abnormal_lysosome_morphology2.38329402
13MP0003705_abnormal_hypodermis_morpholog2.34044013
14MP0010234_abnormal_vibrissa_follicle2.22470750
15MP0005076_abnormal_cell_differentiation2.13230805
16MP0000013_abnormal_adipose_tissue2.06666971
17MP0008438_abnormal_cutaneous_collagen1.92385099
18MP0002837_dystrophic_cardiac_calcinosis1.92050709
19MP0002419_abnormal_innate_immunity1.88791638
20MP0008057_abnormal_DNA_replication1.87624860
21MP0002166_altered_tumor_susceptibility1.87340362
22MP0005387_immune_system_phenotype1.84157947
23MP0001790_abnormal_immune_system1.84157947
24MP0002006_tumorigenesis1.83446891
25MP0003279_aneurysm1.83020904
26MP0005000_abnormal_immune_tolerance1.81957666
27MP0006082_CNS_inflammation1.79888864
28MP0004084_abnormal_cardiac_muscle1.77082146
29MP0004947_skin_inflammation1.76948173
30MP0000604_amyloidosis1.75859559
31MP0010352_gastrointestinal_tract_polyps1.70940998
32MP0003172_abnormal_lysosome_physiology1.69469393
33MP0003252_abnormal_bile_duct1.68639809
34MP0003045_fibrosis1.68400070
35MP0003091_abnormal_cell_migration1.68165763
36MP0001533_abnormal_skeleton_physiology1.66963196
37MP0004215_abnormal_myocardial_fiber1.66232856
38MP0003724_increased_susceptibility_to1.64770588
39MP0003941_abnormal_skin_development1.62904653
40MP0002998_abnormal_bone_remodeling1.59759472
41MP0005257_abnormal_intraocular_pressure1.58203403
42MP0002295_abnormal_pulmonary_circulatio1.56009767
43MP0000749_muscle_degeneration1.55358035
44MP0002254_reproductive_system_inflammat1.54216877
45MP0009785_altered_susceptibility_to1.53952750
46MP0002148_abnormal_hypersensitivity_rea1.50508122
47MP0003195_calcinosis1.49004885
48MP0005671_abnormal_response_to1.47917920
49MP0003566_abnormal_cell_adhesion1.45617551
50MP0003448_altered_tumor_morphology1.45243420
51MP0005275_abnormal_skin_tensile1.43422641
52MP0005248_abnormal_Harderian_gland1.40920506
53MP0002452_abnormal_antigen_presenting1.40886246
54MP0002108_abnormal_muscle_morphology1.39554287
55MP0003890_abnormal_embryonic-extraembry1.39466339
56MP0005025_abnormal_response_to1.38503333
57MP0005171_absent_coat_pigmentation1.36660391
58MP0001800_abnormal_humoral_immune1.34893633
59MP0003453_abnormal_keratinocyte_physiol1.34377097
60MP0010307_abnormal_tumor_latency1.33546377
61MP0002060_abnormal_skin_morphology1.33411113
62MP0000685_abnormal_immune_system1.33273701
63MP0004134_abnormal_chest_morphology1.32714364
64MP0003183_abnormal_peptide_metabolism1.32663370
65MP0009384_cardiac_valve_regurgitation1.31238835
66MP0001542_abnormal_bone_strength1.28928745
67MP0002723_abnormal_immune_serum1.28884072
68MP0000383_abnormal_hair_follicle1.28400114
69MP0009764_decreased_sensitivity_to1.26904772
70MP0009780_abnormal_chondrocyte_physiolo1.26720559
71MP0005379_endocrine/exocrine_gland_phen1.24639821
72MP0001879_abnormal_lymphatic_vessel1.24058993
73MP0008877_abnormal_DNA_methylation1.23977675
74MP0005464_abnormal_platelet_physiology1.23866227
75MP0005408_hypopigmentation1.23338439
76MP0005187_abnormal_penis_morphology1.22665766
77MP0003787_abnormal_imprinting1.22169278
78MP0001299_abnormal_eye_distance/1.20208085
79MP0001845_abnormal_inflammatory_respons1.19705587
80MP0004036_abnormal_muscle_relaxation1.18224294
81MP0005310_abnormal_salivary_gland1.17726347
82MP0005623_abnormal_meninges_morphology1.17028959
83MP0000751_myopathy1.16734962
84MP0002168_other_aberrant_phenotype1.14805251
85MP0002138_abnormal_hepatobiliary_system1.14119516
86MP0001851_eye_inflammation1.14034241
87MP0004130_abnormal_muscle_cell1.13702806
88MP0001958_emphysema1.11469595
89MP0009278_abnormal_bone_marrow1.11195238
90MP0001853_heart_inflammation1.10587991
91MP0003385_abnormal_body_wall1.10457362
92MP0005360_urolithiasis1.10100644
93MP0002009_preneoplasia1.07611384
94MP0010155_abnormal_intestine_physiology1.06769900
95MP0002102_abnormal_ear_morphology1.05803433
96MP0000647_abnormal_sebaceous_gland1.05456091
97MP0010368_abnormal_lymphatic_system1.05304257
98MP0002405_respiratory_system_inflammati1.05162378
99MP0002896_abnormal_bone_mineralization1.03668380
100MP0001819_abnormal_immune_cell1.03538207
101MP0010386_abnormal_urinary_bladder1.03179743
102MP0003755_abnormal_palate_morphology1.02822408
103MP0005174_abnormal_tail_pigmentation1.01912703
104MP0002420_abnormal_adaptive_immunity1.01625295
105MP0002928_abnormal_bile_duct1.00849945
106MP0001984_abnormal_olfaction1.00451432
107MP0009250_abnormal_appendicular_skeleto0.98929950
108MP0005365_abnormal_bile_salt0.98408529
109MP0009046_muscle_twitch0.97919809
110MP0006072_abnormal_retinal_apoptosis0.97665785
111MP0003795_abnormal_bone_structure0.97395426
112MP0002233_abnormal_nose_morphology0.96031528
113MP0003075_altered_response_to0.95584173
114MP0001881_abnormal_mammary_gland0.94576637
115MP0008469_abnormal_protein_level0.94233087
116MP0000003_abnormal_adipose_tissue0.92990982
117MP0005620_abnormal_muscle_contractility0.92851502
118MP0004484_altered_response_of0.92766205
119MP0003937_abnormal_limbs/digits/tail_de0.90587510
120MP0005023_abnormal_wound_healing0.90455751
121MP0005167_abnormal_blood-brain_barrier0.90399505
122MP0002909_abnormal_adrenal_gland0.90276933
123MP0003121_genomic_imprinting0.89403168
124MP0008775_abnormal_heart_ventricle0.89124614
125MP0003868_abnormal_feces_composition0.88831214
126MP0001545_abnormal_hematopoietic_system0.88406121
127MP0005397_hematopoietic_system_phenotyp0.88406121
128MP0010678_abnormal_skin_adnexa0.87940221
129MP0005508_abnormal_skeleton_morphology0.87679379
130MP0005451_abnormal_body_composition0.87261633
131MP0000627_abnormal_mammary_gland0.87240791
132MP0002160_abnormal_reproductive_system0.85643973
133MP0000427_abnormal_hair_cycle0.85374161
134MP0003935_abnormal_craniofacial_develop0.84575783
135MP0005390_skeleton_phenotype0.84526062
136MP0002139_abnormal_hepatobiliary_system0.84089708
137MP0000609_abnormal_liver_physiology0.83667057
138MP0009763_increased_sensitivity_to0.82076379
139MP0005166_decreased_susceptibility_to0.82020069
140MP0000372_irregular_coat_pigmentation0.81895914
141MP0002933_joint_inflammation0.81698472
142MP0009697_abnormal_copulation0.81266193
143MP0000428_abnormal_craniofacial_morphol0.80848673
144MP0001216_abnormal_epidermal_layer0.80770862
145MP0000733_abnormal_muscle_development0.80615921
146MP0000015_abnormal_ear_pigmentation0.80524704
147MP0000767_abnormal_smooth_muscle0.80433238
148MP0002269_muscular_atrophy0.79895509
149MP0000432_abnormal_head_morphology0.78290283
150MP0001243_abnormal_dermal_layer0.77724281
151MP0003828_pulmonary_edema0.75055660
152MP0004185_abnormal_adipocyte_glucose0.74928300
153MP0005253_abnormal_eye_physiology0.74010002
154MP0005551_abnormal_eye_electrophysiolog0.73558050
155MP0000371_diluted_coat_color0.73535979
156MP0002693_abnormal_pancreas_physiology0.73116667
157MP0000249_abnormal_blood_vessel0.73094307
158MP0004043_abnormal_pH_regulation0.72156056
159MP0002938_white_spotting0.71648925
160MP0005369_muscle_phenotype0.71608949
161MP0002177_abnormal_outer_ear0.71309248
162MP0002876_abnormal_thyroid_physiology0.71226092
163MP0005083_abnormal_biliary_tract0.71032215
164MP0000343_altered_response_to0.69841478
165MP0005367_renal/urinary_system_phenotyp0.68619147
166MP0000516_abnormal_urinary_system0.68619147
167MP0004085_abnormal_heartbeat0.68482697
168MP0005595_abnormal_vascular_smooth0.67858546
169MP0000462_abnormal_digestive_system0.67812461
170MP0002127_abnormal_cardiovascular_syste0.67733899
171MP0002972_abnormal_cardiac_muscle0.67255956
172MP0000613_abnormal_salivary_gland0.66648256
173MP0002128_abnormal_blood_circulation0.66024983
174MP0002163_abnormal_gland_morphology0.65198910

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.64462051
2Myocardial infarction (HP:0001658)4.30106392
3Recurrent gram-negative bacterial infections (HP:0005420)3.54407542
4Recurrent bacterial skin infections (HP:0005406)3.51972416
5Prostate neoplasm (HP:0100787)3.46238489
6Recurrent abscess formation (HP:0002722)3.42154540
7Abnormality of the ischium (HP:0003174)3.20025227
8Optic neuritis (HP:0100653)3.05778679
9Retrobulbar optic neuritis (HP:0100654)3.05778679
10Hypoplastic ischia (HP:0003175)3.03578165
11Orchitis (HP:0100796)2.99502055
12Gastrointestinal infarctions (HP:0005244)2.99011935
13Gingivitis (HP:0000230)2.91747252
14Papillary thyroid carcinoma (HP:0002895)2.90148267
15Peritonitis (HP:0002586)2.89153417
16Arterial thrombosis (HP:0004420)2.85433239
17Absent frontal sinuses (HP:0002688)2.82819825
18Osteolytic defects of the phalanges of the hand (HP:0009771)2.79352456
19Osteolytic defects of the hand bones (HP:0009699)2.79352456
20Follicular hyperkeratosis (HP:0007502)2.78544628
21Periodontitis (HP:0000704)2.75584678
22Thick nail (HP:0001805)2.74526505
23Stomatitis (HP:0010280)2.74178043
24Vascular tortuosity (HP:0004948)2.68205523
25Overgrowth (HP:0001548)2.65014463
26Myositis (HP:0100614)2.60265226
27Metaphyseal dysplasia (HP:0100255)2.54129671
28Soft skin (HP:0000977)2.54086928
29Disinhibition (HP:0000734)2.53258686
30Gingival bleeding (HP:0000225)2.52136216
31Abnormality of macrophages (HP:0004311)2.48289165
32Neonatal short-limb short stature (HP:0008921)2.48194574
33Atrophic scars (HP:0001075)2.44148899
34Fair hair (HP:0002286)2.43641297
35Submucous cleft hard palate (HP:0000176)2.38586989
36Arterial tortuosity (HP:0005116)2.37843012
37Hypoplastic labia majora (HP:0000059)2.36784280
38Limited hip movement (HP:0008800)2.36133945
39Hematochezia (HP:0002573)2.32027920
40Protrusio acetabuli (HP:0003179)2.29777632
41Esophageal varix (HP:0002040)2.29035732
42Calf muscle hypertrophy (HP:0008981)2.28629648
43Cardiovascular calcification (HP:0011915)2.27680306
44Autoimmune thrombocytopenia (HP:0001973)2.26786497
45Distal lower limb amyotrophy (HP:0008944)2.25813227
46Lip pit (HP:0100267)2.25731871
47Type 1 muscle fiber predominance (HP:0003803)2.22623043
48Hyperventilation (HP:0002883)2.18200994
49Mitral stenosis (HP:0001718)2.18015876
50Hamartoma of the eye (HP:0010568)2.17951623
51Abnormality of the labia majora (HP:0012881)2.17453471
52Abnormality of the nasal septum (HP:0000419)2.16117564
53Nemaline bodies (HP:0003798)2.13356083
54Increased cerebral lipofuscin (HP:0011813)2.12609661
55Subacute progressive viral hepatitis (HP:0006572)2.12249805
56Renal cortical cysts (HP:0000803)2.11593767
57Abnormality of the calf musculature (HP:0001430)2.11088261
58Pulmonary infiltrates (HP:0002113)2.09504005
59Recurrent fungal infections (HP:0002841)2.08587029
60Delayed gross motor development (HP:0002194)2.08413863
61Cerebral aneurysm (HP:0004944)2.06956874
62Vasculitis (HP:0002633)2.06614100
63Spondylolisthesis (HP:0003302)2.06075043
64Mediastinal lymphadenopathy (HP:0100721)2.05487855
65Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.05043753
66Coronal craniosynostosis (HP:0004440)2.04254506
67Urethral obstruction (HP:0000796)2.03819528
68Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.03707664
69Urinary glycosaminoglycan excretion (HP:0003541)2.02927196
70Mucopolysacchariduria (HP:0008155)2.02927196
71Tetraparesis (HP:0002273)2.02836666
72Recurrent skin infections (HP:0001581)2.02483524
73Abnormality of the fingertips (HP:0001211)1.99873726
74Premature loss of primary teeth (HP:0006323)1.99663355
75Abnormality of mucopolysaccharide metabolism (HP:0011020)1.98498373
76Abnormality of polysaccharide metabolism (HP:0011012)1.98498373
77Abnormality of glycosaminoglycan metabolism (HP:0004371)1.98498373
78Coarse hair (HP:0002208)1.98237941
79Long toe (HP:0010511)1.97990720
80Muscle fiber inclusion bodies (HP:0100299)1.96815054
81Dysostosis multiplex (HP:0000943)1.96790021
82Hydroxyprolinuria (HP:0003080)1.95843149
83Abnormality of proline metabolism (HP:0010907)1.95843149
84Right ventricular cardiomyopathy (HP:0011663)1.93215359
85Muscle hypertrophy of the lower extremities (HP:0008968)1.92613351
86Abnormality of the renal cortex (HP:0011035)1.92422742
87Vacuolated lymphocytes (HP:0001922)1.92290652
88Nephritis (HP:0000123)1.92222181
89Aortic aneurysm (HP:0004942)1.91780932
90Hyporeflexia of lower limbs (HP:0002600)1.91153199
91Wormian bones (HP:0002645)1.90901327
92Hypoplastic scapulae (HP:0000882)1.90822965
93Aplasia/Hypoplasia of the scapulae (HP:0006713)1.90822965
94Pancreatic fibrosis (HP:0100732)1.90538658
95Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.90373444
96Thyroid carcinoma (HP:0002890)1.90350895
97Alopecia of scalp (HP:0002293)1.88745628
98Aneurysm (HP:0002617)1.88398988
99Abnormality of the frontal sinuses (HP:0002687)1.88360653
100Inappropriate behavior (HP:0000719)1.86560719
101Abnormality of the common coagulation pathway (HP:0010990)1.86021389
102Aplasia/Hypoplasia of the tongue (HP:0010295)1.85768629
103Generalized hypopigmentation of hair (HP:0011358)1.85360220
104Curly hair (HP:0002212)1.85013036
105Macroorchidism (HP:0000053)1.84842854
106Pustule (HP:0200039)1.83946041
107Osteomyelitis (HP:0002754)1.83896205
108Chronic hepatic failure (HP:0100626)1.83115844
109Abnormality of the lumbar spine (HP:0100712)1.81532393
110Pulmonic stenosis (HP:0001642)1.80994629
111Acute myeloid leukemia (HP:0004808)1.80475061
112Increased connective tissue (HP:0009025)1.80376412
113Knee flexion contracture (HP:0006380)1.80259397
114Axonal loss (HP:0003447)1.79780731
115Bell-shaped thorax (HP:0001591)1.79778814
116Genital tract atresia (HP:0001827)1.79552800
117Microglossia (HP:0000171)1.79184898
118Proximal amyotrophy (HP:0007126)1.78784246
119Mitral valve prolapse (HP:0001634)1.78759581
120Lower limb amyotrophy (HP:0007210)1.78718874
121Increased density of long bones (HP:0006392)1.78426565
122Persistence of primary teeth (HP:0006335)1.77498041
123Oligodontia (HP:0000677)1.77382291
124Joint hemorrhage (HP:0005261)1.76563804
125Bone pain (HP:0002653)1.75468358
126Keratoconjunctivitis sicca (HP:0001097)1.74965541
127Thoracic kyphosis (HP:0002942)1.74235154
128Dilatation of the ascending aorta (HP:0005111)1.73739339
129Abnormal biliary tract morphology (HP:0012440)1.73049188
130Medial flaring of the eyebrow (HP:0010747)1.72903373
131Amyloidosis (HP:0011034)1.72670287
132Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.72543091
133Difficulty running (HP:0009046)1.72211082
134Drooling (HP:0002307)1.71449850
135Bifid tongue (HP:0010297)1.70901821
136Increased CSF protein (HP:0002922)1.70651130
137Entropion (HP:0000621)1.70019345
138Hypoalphalipoproteinemia (HP:0003233)1.69297776
139Volvulus (HP:0002580)1.69222692
140Increased number of teeth (HP:0011069)1.69204118
141Elevated erythrocyte sedimentation rate (HP:0003565)1.68520414
142Vascular calcification (HP:0004934)1.67123775
143Premature rupture of membranes (HP:0001788)1.66404282
144Increased corneal curvature (HP:0100692)1.66363976
145Keratoconus (HP:0000563)1.66363976
146Frequent falls (HP:0002359)1.66229716
147Increased neuronal autofluorescent lipopigment (HP:0002074)1.66211472
148Natal tooth (HP:0000695)1.66073643
149Aplasia/Hypoplasia of the tibia (HP:0005772)1.65751292
150Wrist flexion contracture (HP:0001239)1.65690923
151Narrow palate (HP:0000189)1.65620315
152Hypoplasia of the iris (HP:0007676)1.65591706
153Gaze-evoked nystagmus (HP:0000640)1.64135615
154Ankle contracture (HP:0006466)1.63755399
155Infantile muscular hypotonia (HP:0008947)1.63705409
156Keratoconjunctivitis (HP:0001096)1.63387540
157Hip dysplasia (HP:0001385)1.62812328
158Tubulointerstitial nephritis (HP:0001970)1.62809371
159Abnormality of the thoracic spine (HP:0100711)1.62116645
160Congenital primary aphakia (HP:0007707)1.61998999
161Hemiparesis (HP:0001269)1.61651041
162Hyperglycemia (HP:0003074)1.61484667
163Abnormality of glutamine family amino acid metabolism (HP:0010902)1.61409133
164Thoracolumbar scoliosis (HP:0002944)1.61059372
165Systemic lupus erythematosus (HP:0002725)1.60865663
166Small hand (HP:0200055)1.59668347
167Aortic dissection (HP:0002647)1.59476073
168Vaginal atresia (HP:0000148)1.59455142
169Autoamputation (HP:0001218)1.59331910
170Advanced eruption of teeth (HP:0006288)1.59194945
171Hyperextensible skin (HP:0000974)1.59170854
172Decreased muscle mass (HP:0003199)1.58699950
173Cupped ribs (HP:0000887)1.58440667
174Pancreatic cysts (HP:0001737)1.58388316
175Spontaneous abortion (HP:0005268)1.58090809
176True hermaphroditism (HP:0010459)1.57587810
177Deep venous thrombosis (HP:0002625)1.57510416
178Aqueductal stenosis (HP:0002410)1.56450957
179Short foot (HP:0001773)1.56416645
180Bundle branch block (HP:0011710)1.55637766
181Gait imbalance (HP:0002141)1.55230032
182Broad metatarsal (HP:0001783)1.54817468
183Abnormality of the astrocytes (HP:0100707)1.53566978
184Astrocytoma (HP:0009592)1.53566978
185Absent speech (HP:0001344)1.52649281

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K143.70764226
2TAOK32.84591417
3AKT32.79391567
4JAK32.73914732
5RIPK42.68448511
6STK38L2.57731318
7MAP3K122.49936800
8LATS12.45485974
9TRIM282.43376409
10MYLK2.29392682
11JAK12.25896117
12TYK22.21343674
13FRK2.21151639
14CASK2.19851298
15PNCK2.15855014
16TTN2.06903631
17EIF2AK31.98897740
18TBK11.97706135
19RIPK11.92842048
20TNIK1.85836095
21IRAK31.85479195
22FGFR21.79589069
23CAMK1D1.77636924
24FGFR31.73181718
25MST41.72409670
26SIK11.71796530
27BMPR1B1.67746877
28PLK21.63135568
29STK391.60369371
30EPHA31.59745102
31MAP3K131.59077070
32PTK61.58277587
33OBSCN1.57050054
34CAMK1G1.50046817
35MAP3K21.48318738
36ACVR1B1.46839672
37CHUK1.45522147
38NEK91.44802823
39BRSK21.43283001
40DMPK1.40097168
41KIT1.38154420
42TRPM71.36543963
43IKBKE1.35185744
44ERBB41.34826591
45FGFR41.34512571
46PDGFRA1.29784611
47JAK21.26796221
48PDGFRB1.26248251
49EPHB11.25349447
50TXK1.25256576
51IKBKB1.23155644
52MAP4K21.21330938
53PINK11.18137222
54BCR1.15645531
55STK31.14903783
56EIF2AK11.14008269
57MAP3K61.13776328
58PIK3CA1.13714799
59WNK31.11935789
60PHKG21.10326796
61PHKG11.10326796
62CDK121.03842344
63SCYL21.02365705
64NLK1.02016232
65MKNK21.01830785
66RET1.01306367
67INSRR0.98980883
68DDR20.98911191
69SGK30.98909120
70SIK20.98880225
71MAP3K50.96865186
72TRIB30.96584733
73TGFBR20.95951323
74MST1R0.95430400
75MAPK130.92425598
76ROCK10.88936488
77HCK0.86268719
78TIE10.86228241
79MET0.85157820
80CSK0.84197804
81PTK2B0.84063419
82IRAK40.83942949
83FGFR10.83915596
84STK240.83756798
85TAOK10.83102795
86LIMK10.82684622
87PRKCH0.81954026
88MAP3K30.81771474
89SGK20.81312498
90ZAP700.78045044
91CDK60.76736698
92WNK10.76210264
93ERN10.75674937
94GRK70.75466972
95GRK10.75235375
96EGFR0.73924097
97HIPK20.73402326
98CDK90.73056340
99WNK40.72755681
100BRD40.72404811
101NUAK10.71450812
102LCK0.70999809
103STK380.70972368
104ABL20.69802911
105KSR20.69258345
106MAP3K70.69203776
107OXSR10.68697058
108PTK20.67292166
109ABL10.65655941
110PAK20.65054245
111SGK10.64656864
112RPS6KA40.64651053
113FER0.64220294
114BMX0.63902892
115ITK0.63528766
116PIK3CG0.61715971
117BMPR20.61709192
118MAP2K30.61666622
119ADRBK10.60507586
120PRKCQ0.60399449
121CSNK1G10.60312836
122IGF1R0.59878337
123TGFBR10.58950230
124MAP3K10.58361716
125FGR0.56311408
126PRKAA20.55759330
127NEK10.55603547
128MELK0.55281821
129MAP2K40.53400664
130NTRK10.53360463
131MARK30.52939686
132PRKG10.52433197
133MTOR0.51763533
134CSNK1G20.50580827
135ERBB30.50325574
136MUSK0.50275356
137LATS20.50151418
138TEC0.49740910
139KSR10.49277767
140PLK40.49022389
141PLK30.48177285
142NTRK30.46866542
143EPHB20.46361832
144PBK0.44108288
145GSK3A0.43694835
146ROCK20.42332257
147EIF2AK20.41771133
148CAMKK20.41707198
149STK100.41540991
150LMTK20.40115388
151MAPKAPK30.39949628
152PRKCE0.39732031
153PDK10.39388071
154CAMK2D0.38757565
155PRKACB0.38458176
156INSR0.38275005
157WEE10.38188855
158MAP3K40.37896605
159PAK30.37871035
160MAPK100.37249863
161CAMK2A0.37149218
162ATM0.36638918
163PDK20.36242219
164PRKAA10.35927709
165SGK4940.35914044
166SGK2230.35914044

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.11028254
2Circadian rhythm_Homo sapiens_hsa047102.47852752
3Leishmaniasis_Homo sapiens_hsa051402.04968258
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.98523820
5Staphylococcus aureus infection_Homo sapiens_hsa051501.83088574
6Osteoclast differentiation_Homo sapiens_hsa043801.82925042
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.81984809
8Graft-versus-host disease_Homo sapiens_hsa053321.81824340
9Toll-like receptor signaling pathway_Homo sapiens_hsa046201.79540311
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.78205059
11NF-kappa B signaling pathway_Homo sapiens_hsa040641.77249164
12TNF signaling pathway_Homo sapiens_hsa046681.72040075
13Allograft rejection_Homo sapiens_hsa053301.71711119
14NOD-like receptor signaling pathway_Homo sapiens_hsa046211.68102843
15Non-homologous end-joining_Homo sapiens_hsa034501.58669637
16Type I diabetes mellitus_Homo sapiens_hsa049401.53761636
17TGF-beta signaling pathway_Homo sapiens_hsa043501.53061744
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.52397719
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.52168556
20Malaria_Homo sapiens_hsa051441.46574246
21Propanoate metabolism_Homo sapiens_hsa006401.46299415
22* Tuberculosis_Homo sapiens_hsa051521.45630999
23Renin secretion_Homo sapiens_hsa049241.45528019
24Measles_Homo sapiens_hsa051621.42747255
25Toxoplasmosis_Homo sapiens_hsa051451.42470826
26Type II diabetes mellitus_Homo sapiens_hsa049301.37724372
27Insulin secretion_Homo sapiens_hsa049111.30550193
28Tight junction_Homo sapiens_hsa045301.30320538
29Pertussis_Homo sapiens_hsa051331.29710695
30Amoebiasis_Homo sapiens_hsa051461.28831954
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.26720380
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.24230588
33Dorso-ventral axis formation_Homo sapiens_hsa043201.22002156
34cGMP-PKG signaling pathway_Homo sapiens_hsa040221.21001115
35Influenza A_Homo sapiens_hsa051641.20593577
36Hippo signaling pathway_Homo sapiens_hsa043901.19784904
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19444678
38Rheumatoid arthritis_Homo sapiens_hsa053231.19252863
39Salmonella infection_Homo sapiens_hsa051321.17602179
40Prolactin signaling pathway_Homo sapiens_hsa049171.17415577
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.17070901
42Legionellosis_Homo sapiens_hsa051341.14907677
43Pancreatic cancer_Homo sapiens_hsa052121.14072765
44Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12142018
45Asthma_Homo sapiens_hsa053101.12024172
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.11186318
47Hedgehog signaling pathway_Homo sapiens_hsa043401.10984086
48ABC transporters_Homo sapiens_hsa020101.10141307
49Protein digestion and absorption_Homo sapiens_hsa049741.08541279
50Sphingolipid metabolism_Homo sapiens_hsa006001.08294601
51Lysosome_Homo sapiens_hsa041421.07466848
52Insulin resistance_Homo sapiens_hsa049311.07229028
53Nitrogen metabolism_Homo sapiens_hsa009101.06984511
54Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.05766224
55Vascular smooth muscle contraction_Homo sapiens_hsa042701.05340529
56B cell receptor signaling pathway_Homo sapiens_hsa046621.03843156
57Complement and coagulation cascades_Homo sapiens_hsa046101.03196034
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03000446
59Caffeine metabolism_Homo sapiens_hsa002321.02966606
60T cell receptor signaling pathway_Homo sapiens_hsa046601.00676025
61Selenocompound metabolism_Homo sapiens_hsa004501.00468696
62Autoimmune thyroid disease_Homo sapiens_hsa053200.99583604
63Chemokine signaling pathway_Homo sapiens_hsa040620.99147820
64Hepatitis B_Homo sapiens_hsa051610.96989516
65Butanoate metabolism_Homo sapiens_hsa006500.96652405
66Adipocytokine signaling pathway_Homo sapiens_hsa049200.96495175
67Chronic myeloid leukemia_Homo sapiens_hsa052200.96007797
68African trypanosomiasis_Homo sapiens_hsa051430.94924426
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94796716
70* Phagosome_Homo sapiens_hsa041450.92331044
71Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.91805905
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91151649
73Salivary secretion_Homo sapiens_hsa049700.90171980
74Glycosaminoglycan degradation_Homo sapiens_hsa005310.90065493
75Mineral absorption_Homo sapiens_hsa049780.89344879
76Hepatitis C_Homo sapiens_hsa051600.88722894
77Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.88615709
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.87668393
79Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.87661751
80Steroid biosynthesis_Homo sapiens_hsa001000.87621955
81Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87533717
82Circadian entrainment_Homo sapiens_hsa047130.85905359
83Apoptosis_Homo sapiens_hsa042100.85720141
84Proteoglycans in cancer_Homo sapiens_hsa052050.85310715
85mTOR signaling pathway_Homo sapiens_hsa041500.85113186
86Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.85084799
87Focal adhesion_Homo sapiens_hsa045100.82952589
88p53 signaling pathway_Homo sapiens_hsa041150.82477596
89Long-term depression_Homo sapiens_hsa047300.81895110
90Glucagon signaling pathway_Homo sapiens_hsa049220.81787094
91PI3K-Akt signaling pathway_Homo sapiens_hsa041510.80727544
92Platelet activation_Homo sapiens_hsa046110.80415271
93Hematopoietic cell lineage_Homo sapiens_hsa046400.80330849
94Small cell lung cancer_Homo sapiens_hsa052220.79944525
95Oxytocin signaling pathway_Homo sapiens_hsa049210.79115314
96Viral myocarditis_Homo sapiens_hsa054160.78761252
97Phototransduction_Homo sapiens_hsa047440.77449150
98Intestinal immune network for IgA production_Homo sapiens_hsa046720.77349621
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76912056
100Arginine biosynthesis_Homo sapiens_hsa002200.76774362
101Sulfur metabolism_Homo sapiens_hsa009200.76758140
102Shigellosis_Homo sapiens_hsa051310.75996410
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75234685
104Glutamatergic synapse_Homo sapiens_hsa047240.75001185
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74794334
106Amphetamine addiction_Homo sapiens_hsa050310.74195226
107Wnt signaling pathway_Homo sapiens_hsa043100.73917235
108Dopaminergic synapse_Homo sapiens_hsa047280.73705003
109Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72776173
110Axon guidance_Homo sapiens_hsa043600.72366223
111Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72254378
112Vitamin B6 metabolism_Homo sapiens_hsa007500.71848911
113Adherens junction_Homo sapiens_hsa045200.71349635
114Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.70870712
115Prostate cancer_Homo sapiens_hsa052150.70242198
116Fanconi anemia pathway_Homo sapiens_hsa034600.70125668
117MicroRNAs in cancer_Homo sapiens_hsa052060.69958376
118Basal transcription factors_Homo sapiens_hsa030220.69952664
119Fatty acid biosynthesis_Homo sapiens_hsa000610.69656783
120Thyroid hormone synthesis_Homo sapiens_hsa049180.69002834
121Glioma_Homo sapiens_hsa052140.68880684
122Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.68056947
123Leukocyte transendothelial migration_Homo sapiens_hsa046700.67557278
124Calcium signaling pathway_Homo sapiens_hsa040200.67137227
125ECM-receptor interaction_Homo sapiens_hsa045120.66960870
126cAMP signaling pathway_Homo sapiens_hsa040240.66470045
127Lysine degradation_Homo sapiens_hsa003100.65579197
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65138145
129Vibrio cholerae infection_Homo sapiens_hsa051100.64593787
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.64081332
131Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64067793
132Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64064168
133Acute myeloid leukemia_Homo sapiens_hsa052210.63666495
134Melanogenesis_Homo sapiens_hsa049160.62297497
135Serotonergic synapse_Homo sapiens_hsa047260.60572338
136Steroid hormone biosynthesis_Homo sapiens_hsa001400.59612478
137Pancreatic secretion_Homo sapiens_hsa049720.59073884
138Fatty acid degradation_Homo sapiens_hsa000710.58984045
139Renal cell carcinoma_Homo sapiens_hsa052110.58341219
140Ether lipid metabolism_Homo sapiens_hsa005650.57824515
141Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57707095
142VEGF signaling pathway_Homo sapiens_hsa043700.56910769
143Collecting duct acid secretion_Homo sapiens_hsa049660.56128668
144Taste transduction_Homo sapiens_hsa047420.55291152
145Basal cell carcinoma_Homo sapiens_hsa052170.55248471
146FoxO signaling pathway_Homo sapiens_hsa040680.54849102
147Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54715838
148Fatty acid metabolism_Homo sapiens_hsa012120.54084929
149Folate biosynthesis_Homo sapiens_hsa007900.54021821
150Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.53543270
151Gastric acid secretion_Homo sapiens_hsa049710.53425536
152Herpes simplex infection_Homo sapiens_hsa051680.52494236
153Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52312334
154Sphingolipid signaling pathway_Homo sapiens_hsa040710.51979505
155Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51550763
156Melanoma_Homo sapiens_hsa052180.51165053
157Tryptophan metabolism_Homo sapiens_hsa003800.50343912
158GnRH signaling pathway_Homo sapiens_hsa049120.49769086
159Pathways in cancer_Homo sapiens_hsa052000.49629180
160Ras signaling pathway_Homo sapiens_hsa040140.49551276
161Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49540710
162Inositol phosphate metabolism_Homo sapiens_hsa005620.49312265
163Choline metabolism in cancer_Homo sapiens_hsa052310.48755213
164AMPK signaling pathway_Homo sapiens_hsa041520.48516182
165Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48413320
166Primary bile acid biosynthesis_Homo sapiens_hsa001200.48184537
167Dilated cardiomyopathy_Homo sapiens_hsa054140.47832331
168PPAR signaling pathway_Homo sapiens_hsa033200.47489279
169Bile secretion_Homo sapiens_hsa049760.46574297
170Estrogen signaling pathway_Homo sapiens_hsa049150.46545289
171Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45635633
172ErbB signaling pathway_Homo sapiens_hsa040120.43736422
173MAPK signaling pathway_Homo sapiens_hsa040100.43573240
174Starch and sucrose metabolism_Homo sapiens_hsa005000.42967246

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