EDRF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene may play a role in erythroid cell differentiation. The encoded protein inhibits DNA binding of the erythroid transcription factor GATA-1 and may regulate the expression of alpha-globin and gamma-globin. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.97127345
2nuclear pore organization (GO:0006999)5.81644574
3mitotic chromosome condensation (GO:0007076)5.27568688
4piRNA metabolic process (GO:0034587)5.00686591
5pre-miRNA processing (GO:0031054)4.83412167
6mitotic sister chromatid cohesion (GO:0007064)4.67845271
7histone H2A monoubiquitination (GO:0035518)4.62608194
8negative regulation of histone methylation (GO:0031061)4.61004594
9somatic diversification of immune receptors via somatic mutation (GO:0002566)4.59678078
10somatic hypermutation of immunoglobulin genes (GO:0016446)4.59678078
11protein localization to kinetochore (GO:0034501)4.57467771
12mitotic nuclear envelope disassembly (GO:0007077)4.52100647
13attachment of spindle microtubules to kinetochore (GO:0008608)4.50125242
14mitotic metaphase plate congression (GO:0007080)4.42203161
15positive regulation of mitotic sister chromatid separation (GO:1901970)4.34364406
16positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.34364406
17positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.34364406
18nuclear envelope disassembly (GO:0051081)4.29512032
19membrane disassembly (GO:0030397)4.29512032
20metaphase plate congression (GO:0051310)4.29207989
21regulation of sister chromatid cohesion (GO:0007063)4.28705618
22pore complex assembly (GO:0046931)4.23102211
23regulation of spindle organization (GO:0090224)4.11271482
24positive regulation of chromosome segregation (GO:0051984)4.08004661
25regulation of histone H3-K9 methylation (GO:0051570)4.06444310
26gene silencing by RNA (GO:0031047)4.06435565
27protein localization to chromosome, centromeric region (GO:0071459)4.00285303
28meiotic chromosome segregation (GO:0045132)3.97240368
29rRNA catabolic process (GO:0016075)3.89823294
30regulation of mitotic spindle organization (GO:0060236)3.89343650
31folic acid-containing compound biosynthetic process (GO:0009396)3.84062737
32DNA methylation involved in gamete generation (GO:0043046)3.83164451
33negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.77439703
34regulation of RNA export from nucleus (GO:0046831)3.71979640
35establishment of chromosome localization (GO:0051303)3.68595318
36sister chromatid segregation (GO:0000819)3.64500100
37DNA alkylation (GO:0006305)3.61336276
38DNA methylation (GO:0006306)3.61336276
39monoubiquitinated protein deubiquitination (GO:0035520)3.60874263
40protein localization to chromosome (GO:0034502)3.53923961
41DNA replication-dependent nucleosome assembly (GO:0006335)3.51813023
42DNA replication-dependent nucleosome organization (GO:0034723)3.51813023
43mitotic sister chromatid segregation (GO:0000070)3.51562893
44regulation of centrosome duplication (GO:0010824)3.51471522
45regulation of centriole replication (GO:0046599)3.48851299
46female gamete generation (GO:0007292)3.48199327
47DNA double-strand break processing (GO:0000729)3.47698391
48histone H2A ubiquitination (GO:0033522)3.44945276
49cytoplasmic mRNA processing body assembly (GO:0033962)3.41114570
50sister chromatid cohesion (GO:0007062)3.40340231
51negative regulation of DNA-dependent DNA replication (GO:2000104)3.39276464
52regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.37635193
53protein K11-linked deubiquitination (GO:0035871)3.36816319
54centriole replication (GO:0007099)3.36171844
55regulation of meiosis I (GO:0060631)3.35421569
56double-strand break repair via nonhomologous end joining (GO:0006303)3.34270906
57non-recombinational repair (GO:0000726)3.34270906
58DNA unwinding involved in DNA replication (GO:0006268)3.32570588
59replication fork processing (GO:0031297)3.31968411
60nuclear envelope organization (GO:0006998)3.30843220
61gene silencing (GO:0016458)3.30528752
62regulation of DNA endoreduplication (GO:0032875)3.29652393
63histone H3-K9 methylation (GO:0051567)3.26977184
64synaptonemal complex assembly (GO:0007130)3.23929769
65neural tube formation (GO:0001841)3.23648373
66regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.23269354
67male meiosis (GO:0007140)3.23112863
68chromatin assembly (GO:0031497)3.22335395
69microtubule depolymerization (GO:0007019)3.22254735
70resolution of meiotic recombination intermediates (GO:0000712)3.22192720
71DNA duplex unwinding (GO:0032508)3.19258167
72DNA geometric change (GO:0032392)3.17722549
73regulation of centrosome cycle (GO:0046605)3.16148415
74chromatin assembly or disassembly (GO:0006333)3.14415619
75regulation of chromosome segregation (GO:0051983)3.13381270
76maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.13039487
77protein K63-linked deubiquitination (GO:0070536)3.12860149
78meiotic cell cycle (GO:0051321)3.11033713
79spindle checkpoint (GO:0031577)3.10793491
80single strand break repair (GO:0000012)3.10377267
81peptidyl-lysine trimethylation (GO:0018023)3.09674244
82regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.09106913
83regulation of nucleobase-containing compound transport (GO:0032239)3.08554444
84ncRNA catabolic process (GO:0034661)3.08224776
85regulation of mitotic metaphase/anaphase transition (GO:0030071)3.07617059
86chromosome segregation (GO:0007059)3.07467508
87kinetochore organization (GO:0051383)3.05065407
88negative regulation of meiosis (GO:0045835)3.05041203
89negative regulation of histone modification (GO:0031057)3.03996034
90RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.03789072
91double-strand break repair via homologous recombination (GO:0000724)3.03300258
92regulation of posttranscriptional gene silencing (GO:0060147)3.02510696
93regulation of gene silencing by miRNA (GO:0060964)3.02510696
94regulation of gene silencing by RNA (GO:0060966)3.02510696
95intra-S DNA damage checkpoint (GO:0031573)3.02498680
96nucleus organization (GO:0006997)3.01853163
97nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.01735576
98mitochondrial RNA metabolic process (GO:0000959)3.01362913
99recombinational repair (GO:0000725)3.01060375
100chromosome condensation (GO:0030261)3.00562936
101centrosome duplication (GO:0051298)2.99774985
102negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.98828263
103negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.98820034
104negative regulation of translation, ncRNA-mediated (GO:0040033)2.98820034
105regulation of translation, ncRNA-mediated (GO:0045974)2.98820034
106establishment of protein localization to Golgi (GO:0072600)2.98143347
107mitotic spindle checkpoint (GO:0071174)2.97098892
108protein K48-linked deubiquitination (GO:0071108)2.96967665
109regulation of DNA methylation (GO:0044030)2.95927689
110acrosome reaction (GO:0007340)2.94002609
111DNA strand elongation involved in DNA replication (GO:0006271)2.93970613
112histone mRNA catabolic process (GO:0071044)2.92948977
113regulation of mitotic sister chromatid separation (GO:0010965)2.92722675
114regulation of mitotic sister chromatid segregation (GO:0033047)2.92722675
115regulation of sister chromatid segregation (GO:0033045)2.92722675
116DNA replication-independent nucleosome assembly (GO:0006336)2.92500808
117DNA replication-independent nucleosome organization (GO:0034724)2.92500808
118regulation of female gonad development (GO:2000194)2.91969299
119microtubule nucleation (GO:0007020)2.90266267
120negative regulation of chromatin modification (GO:1903309)2.88426373
121DNA replication checkpoint (GO:0000076)2.88263273
122histone exchange (GO:0043486)2.88199590
123chromatin remodeling at centromere (GO:0031055)2.87315985
124DNA methylation or demethylation (GO:0044728)2.86910519
125regulation of retinoic acid receptor signaling pathway (GO:0048385)2.85723958
126spindle assembly checkpoint (GO:0071173)2.85580812
127regulation of mitotic spindle checkpoint (GO:1903504)2.84997651
128regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.84997651
129oogenesis (GO:0048477)2.83859126
130histone H3-K9 modification (GO:0061647)2.83839406
131negative regulation of chromosome segregation (GO:0051985)2.83597573
132protein K6-linked ubiquitination (GO:0085020)2.83518372
133ribosome assembly (GO:0042255)2.82648830
134somatic diversification of immunoglobulins (GO:0016445)2.82476369
135histone lysine demethylation (GO:0070076)2.82078152
136one-carbon metabolic process (GO:0006730)2.81987029
137DNA conformation change (GO:0071103)2.81843385
138DNA replication initiation (GO:0006270)2.81775145
139sperm-egg recognition (GO:0035036)2.81382538
140microtubule anchoring (GO:0034453)2.80979722
141mitotic spindle assembly checkpoint (GO:0007094)2.80497752
142histone demethylation (GO:0016577)2.80487960
143double-strand break repair (GO:0006302)2.80321569
144DNA packaging (GO:0006323)2.80245113
145DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.77942163
146DNA strand elongation (GO:0022616)2.77694421
147histone H3-K4 trimethylation (GO:0080182)2.77658077
148spliceosomal tri-snRNP complex assembly (GO:0000244)2.75857654
149chromatin silencing (GO:0006342)2.75728497
150somatic diversification of immune receptors (GO:0002200)2.73950349
151peptidyl-lysine methylation (GO:0018022)2.73685271
152histone lysine methylation (GO:0034968)2.72947701
153regulation of double-strand break repair via homologous recombination (GO:0010569)2.72903794
154CENP-A containing nucleosome assembly (GO:0034080)2.72867896
155DNA synthesis involved in DNA repair (GO:0000731)2.71964908
156somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.71350407
157somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.71350407
158isotype switching (GO:0045190)2.71350407
159somatic recombination of immunoglobulin gene segments (GO:0016447)2.70924420
160telomere maintenance via recombination (GO:0000722)2.69197109

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.96866384
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.79403715
3SALL1_21062744_ChIP-ChIP_HESCs_Human4.86811619
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.98429083
5KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.60693982
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.28111518
7AR_21909140_ChIP-Seq_LNCAP_Human3.21207513
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.68104302
9ZNF274_21170338_ChIP-Seq_K562_Hela2.61678002
10FUS_26573619_Chip-Seq_HEK293_Human2.58422841
11E2F1_21310950_ChIP-Seq_MCF-7_Human2.55691897
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.48060961
13NOTCH1_21737748_ChIP-Seq_TLL_Human2.34809921
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.22122671
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.19651542
16EWS_26573619_Chip-Seq_HEK293_Human2.15094089
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.06178966
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.02338648
19ELK1_19687146_ChIP-ChIP_HELA_Human2.01601616
20MYC_18555785_ChIP-Seq_MESCs_Mouse1.99889481
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.97827494
22NELFA_20434984_ChIP-Seq_ESCs_Mouse1.97478180
23MYC_22102868_ChIP-Seq_BL_Human1.95587877
24MYCN_18555785_ChIP-Seq_MESCs_Mouse1.94917313
25IGF1R_20145208_ChIP-Seq_DFB_Human1.94517657
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.94031568
27TAF15_26573619_Chip-Seq_HEK293_Human1.92285369
28EST1_17652178_ChIP-ChIP_JURKAT_Human1.88480924
29VDR_22108803_ChIP-Seq_LS180_Human1.85953099
30IRF1_19129219_ChIP-ChIP_H3396_Human1.83042862
31SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.82229359
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78529627
33GABP_17652178_ChIP-ChIP_JURKAT_Human1.74539286
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.74360620
35ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.69655259
36SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.69188066
37HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.68077433
38ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.65916187
39ER_23166858_ChIP-Seq_MCF-7_Human1.63886920
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.61242189
41SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.60640805
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.58610127
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57875581
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.56877177
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.56543645
46MYC_19079543_ChIP-ChIP_MESCs_Mouse1.51282866
47CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.50374286
48IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.50222310
49CBP_20019798_ChIP-Seq_JUKART_Human1.50222310
50MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.48646053
51PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.48206333
52MYC_19030024_ChIP-ChIP_MESCs_Mouse1.44433613
53POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.43675628
54KDM5A_27292631_Chip-Seq_BREAST_Human1.43671812
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43218890
56PKCTHETA_26484144_Chip-Seq_BREAST_Human1.42032462
57NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.40963302
58NANOG_21062744_ChIP-ChIP_HESCs_Human1.39292062
59TP63_19390658_ChIP-ChIP_HaCaT_Human1.39005673
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.38835792
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.37037889
62ETS1_20019798_ChIP-Seq_JURKAT_Human1.36205338
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.34807742
64SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30990722
65CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.30019879
66GBX2_23144817_ChIP-Seq_PC3_Human1.29822535
67DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.29279536
68EGR1_23403033_ChIP-Seq_LIVER_Mouse1.27491323
69TCF3_18692474_ChIP-Seq_MESCs_Mouse1.27040868
70CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26156610
71IRF8_22096565_ChIP-ChIP_GC-B_Human1.25262486
72FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.23389770
73NANOG_18555785_ChIP-Seq_MESCs_Mouse1.19488531
74MYB_26560356_Chip-Seq_TH2_Human1.19266014
75P300_19829295_ChIP-Seq_ESCs_Human1.18922824
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17387271
77CIITA_25753668_ChIP-Seq_RAJI_Human1.16856204
78NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.16630060
79TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15573352
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15573352
81TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.15085085
82KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14900104
83AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14616660
84STAT3_23295773_ChIP-Seq_U87_Human1.14405909
85ELF1_17652178_ChIP-ChIP_JURKAT_Human1.14281644
86HOXB4_20404135_ChIP-ChIP_EML_Mouse1.13646825
87ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12205866
88DCP1A_22483619_ChIP-Seq_HELA_Human1.11378439
89PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11331673
90ZFX_18555785_ChIP-Seq_MESCs_Mouse1.08565666
91TCF3_18692474_ChIP-Seq_MEFs_Mouse1.08496834
92LXR_22158963_ChIP-Seq_LIVER_Mouse1.07748980
93GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06975845
94RXR_22158963_ChIP-Seq_LIVER_Mouse1.06841463
95EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06414497
96E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06394304
97FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.06392013
98ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06341748
99HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.04146089
100GATA1_22025678_ChIP-Seq_K562_Human1.03956435
101CHD1_26751641_Chip-Seq_LNCaP_Human1.03701636
102FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.03185469
103JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.02306087
104PPARA_22158963_ChIP-Seq_LIVER_Mouse1.01219083
105STAT3_1855785_ChIP-Seq_MESCs_Mouse1.00868275
106CREB1_15753290_ChIP-ChIP_HEK293T_Human1.00624200
107SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00419847
108CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.99671965
109ESR1_15608294_ChIP-ChIP_MCF-7_Human0.98707626
110MYB_26560356_Chip-Seq_TH1_Human0.97260749
111TFEB_21752829_ChIP-Seq_HELA_Human0.95738512
112SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95325887
113DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95228994
114GATA3_26560356_Chip-Seq_TH2_Human0.94954202
115FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.94777555
116TCF4_23295773_ChIP-Seq_U87_Human0.92585469
117POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91835664
118PCGF2_27294783_Chip-Seq_ESCs_Mouse0.91700955
119IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.91136752
120SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.90956746
121MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90883563
122ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.90493055
123CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.89349622
124TTF2_22483619_ChIP-Seq_HELA_Human0.89197393
125KLF5_20875108_ChIP-Seq_MESCs_Mouse0.88480311
126GATA3_26560356_Chip-Seq_TH1_Human0.87611331
127KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.86945877
128KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.86945877
129KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.86945877
130KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.86812061
131SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.85385023
132HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.85235109
133POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.85044196
134VDR_23849224_ChIP-Seq_CD4+_Human0.84126102
135EZH2_27294783_Chip-Seq_NPCs_Mouse0.83624407
136TBX3_20139965_ChIP-Seq_ESCs_Mouse0.83490482
137XRN2_22483619_ChIP-Seq_HELA_Human0.82539003
138TBX3_20139965_ChIP-Seq_MESCs_Mouse0.81823429
139TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.81351612
140DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.81154623
141TP53_22573176_ChIP-Seq_HFKS_Human0.81141511
142TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.81050090
143AUTS2_25519132_ChIP-Seq_293T-REX_Human0.80926882
144GATA3_27048872_Chip-Seq_THYMUS_Human0.80800529
145FOXA2_19822575_ChIP-Seq_HepG2_Human0.80415766
146GABP_19822575_ChIP-Seq_HepG2_Human0.80192357
147MYC_18358816_ChIP-ChIP_MESCs_Mouse0.79969433
148RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.79811759
149GATA6_25053715_ChIP-Seq_YYC3_Human0.79102557
150POU5F1_16518401_ChIP-PET_MESCs_Mouse0.79046358
151E2F1_18555785_ChIP-Seq_MESCs_Mouse0.78793246
152MYC_18940864_ChIP-ChIP_HL60_Human0.78784874
153FOXP3_21729870_ChIP-Seq_TREG_Human0.78494415
154FLI1_21867929_ChIP-Seq_TH2_Mouse0.78068977
155AR_25329375_ChIP-Seq_VCAP_Human0.77242469
156PCGF2_27294783_Chip-Seq_NPCs_Mouse0.77171245
157NANOG_16518401_ChIP-PET_MESCs_Mouse0.76727424
158MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.76296998
159TCF7_22412390_ChIP-Seq_EML_Mouse0.75810872
160CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.75603594
161FOXO3_23340844_ChIP-Seq_DLD1_Human0.72149878
162CLOCK_20551151_ChIP-Seq_293T_Human0.71038837

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.10743699
2MP0008877_abnormal_DNA_methylation3.84030698
3MP0002009_preneoplasia3.78234849
4MP0003693_abnormal_embryo_hatching3.44629522
5MP0003111_abnormal_nucleus_morphology3.28740170
6MP0003077_abnormal_cell_cycle3.26519696
7MP0004957_abnormal_blastocyst_morpholog3.12970306
8MP0003718_maternal_effect3.11970885
9MP0008057_abnormal_DNA_replication2.78573621
10MP0005410_abnormal_fertilization2.67275065
11MP0010352_gastrointestinal_tract_polyps2.61871580
12MP0002139_abnormal_hepatobiliary_system2.56618704
13MP0001730_embryonic_growth_arrest2.48428240
14MP0003123_paternal_imprinting2.43607043
15MP0003787_abnormal_imprinting2.29374292
16MP0003890_abnormal_embryonic-extraembry2.29032884
17MP0004264_abnormal_extraembryonic_tissu2.24580758
18MP0003705_abnormal_hypodermis_morpholog2.24304444
19MP0008058_abnormal_DNA_repair2.23987498
20MP0003121_genomic_imprinting2.21637825
21MP0002166_altered_tumor_susceptibility2.20882121
22MP0005360_urolithiasis2.20093226
23MP0010307_abnormal_tumor_latency2.12441601
24MP0000350_abnormal_cell_proliferation2.11607166
25MP0010234_abnormal_vibrissa_follicle2.05686739
26MP0005365_abnormal_bile_salt1.98495349
27MP0005076_abnormal_cell_differentiation1.94512999
28MP0001672_abnormal_embryogenesis/_devel1.90222902
29MP0005380_embryogenesis_phenotype1.90222902
30MP0003806_abnormal_nucleotide_metabolis1.89967889
31MP0002084_abnormal_developmental_patter1.85859324
32MP0002006_tumorigenesis1.77601584
33MP0001697_abnormal_embryo_size1.75878562
34MP0001929_abnormal_gametogenesis1.71766651
35MP0002085_abnormal_embryonic_tissue1.70001744
36MP0002086_abnormal_extraembryonic_tissu1.69850654
37MP0002210_abnormal_sex_determination1.69614391
38MP0005085_abnormal_gallbladder_physiolo1.67443116
39MP0003984_embryonic_growth_retardation1.66344466
40MP0008961_abnormal_basal_metabolism1.66227729
41MP0003221_abnormal_cardiomyocyte_apopto1.65579048
42MP0002088_abnormal_embryonic_growth/wei1.63046714
43MP0000653_abnormal_sex_gland1.59287293
44MP0008007_abnormal_cellular_replicative1.58519710
45MP0003763_abnormal_thymus_physiology1.56922256
46MP0008932_abnormal_embryonic_tissue1.55363051
47MP0001119_abnormal_female_reproductive1.54830561
48MP0003699_abnormal_female_reproductive1.53461311
49MP0004197_abnormal_fetal_growth/weight/1.50780441
50MP0001915_intracranial_hemorrhage1.42651500
51MP0005395_other_phenotype1.41359351
52MP0008995_early_reproductive_senescence1.40205851
53MP0001145_abnormal_male_reproductive1.39037684
54MP0002080_prenatal_lethality1.38535007
55MP0009672_abnormal_birth_weight1.37596595
56MP0003937_abnormal_limbs/digits/tail_de1.31145590
57MP0000569_abnormal_digit_pigmentation1.29869026
58MP0004185_abnormal_adipocyte_glucose1.29465590
59MP0005187_abnormal_penis_morphology1.27572149
60MP0002160_abnormal_reproductive_system1.27196796
61MP0002396_abnormal_hematopoietic_system1.23992365
62MP0003252_abnormal_bile_duct1.17792268
63MP0009703_decreased_birth_body1.17450095
64MP0003119_abnormal_digestive_system1.15803959
65MP0005408_hypopigmentation1.09099742
66MP0006292_abnormal_olfactory_placode1.08718121
67MP0006035_abnormal_mitochondrial_morpho1.08491365
68MP0002019_abnormal_tumor_incidence1.07655134
69MP0005310_abnormal_salivary_gland1.06613236
70MP0001800_abnormal_humoral_immune1.01016440
71MP0001919_abnormal_reproductive_system1.00559155
72MP0002653_abnormal_ependyma_morphology1.00526235
73MP0009053_abnormal_anal_canal0.99926707
74MP0002161_abnormal_fertility/fecundity0.98116623
75MP0002398_abnormal_bone_marrow0.97100937
76MP0002877_abnormal_melanocyte_morpholog0.92305015
77MP0003567_abnormal_fetal_cardiomyocyte0.92216671
78MP0005621_abnormal_cell_physiology0.92041461
79MP0001835_abnormal_antigen_presentation0.90443898
80MP0005023_abnormal_wound_healing0.90209327
81MP0003300_gastrointestinal_ulcer0.89949298
82MP0005266_abnormal_metabolism0.88564979
83MP0005451_abnormal_body_composition0.87077904
84MP0000609_abnormal_liver_physiology0.86858058
85MP0000313_abnormal_cell_death0.85710265
86MP0006072_abnormal_retinal_apoptosis0.84975489
87MP0008875_abnormal_xenobiotic_pharmacok0.84038193
88MP0000689_abnormal_spleen_morphology0.83187841
89MP0004808_abnormal_hematopoietic_stem0.83169837
90MP0005075_abnormal_melanosome_morpholog0.83167888
91MP0001849_ear_inflammation0.81981909
92MP0003698_abnormal_male_reproductive0.81169989
93MP0003183_abnormal_peptide_metabolism0.81164962
94MP0005647_abnormal_sex_gland0.80540363
95MP0005384_cellular_phenotype0.79259868
96MP0003646_muscle_fatigue0.78971141
97MP0000427_abnormal_hair_cycle0.78697324
98MP0002102_abnormal_ear_morphology0.78298780
99MP0002722_abnormal_immune_system0.77806575
100MP0003115_abnormal_respiratory_system0.77425063
101MP0001286_abnormal_eye_development0.76340252
102MP0005253_abnormal_eye_physiology0.76227457
103MP0001661_extended_life_span0.76054974
104MP0005248_abnormal_Harderian_gland0.74863361
105MP0010329_abnormal_lipoprotein_level0.74751653
106MP0000733_abnormal_muscle_development0.74738075
107MP0004233_abnormal_muscle_weight0.74611978
108MP0002925_abnormal_cardiovascular_devel0.74468507
109MP0003935_abnormal_craniofacial_develop0.74297725
110MP0000537_abnormal_urethra_morphology0.73837404
111MP0003453_abnormal_keratinocyte_physiol0.73249769
112MP0005551_abnormal_eye_electrophysiolog0.73047738
113MP0009697_abnormal_copulation0.72245449
114MP0003315_abnormal_perineum_morphology0.72140022
115MP0003868_abnormal_feces_composition0.72110085
116MP0003943_abnormal_hepatobiliary_system0.71285759
117MP0001293_anophthalmia0.71238196
118MP0001873_stomach_inflammation0.70812483
119MP0000432_abnormal_head_morphology0.69146761
120MP0003786_premature_aging0.69144659
121MP0001348_abnormal_lacrimal_gland0.68749383
122MP0005220_abnormal_exocrine_pancreas0.68503320
123MP0000703_abnormal_thymus_morphology0.68445549
124MP0003936_abnormal_reproductive_system0.67625591
125MP0003566_abnormal_cell_adhesion0.67564358
126MP0005389_reproductive_system_phenotype0.66967221
127MP0000358_abnormal_cell_content/0.66564345
128MP0000598_abnormal_liver_morphology0.66419236
129MP0003091_abnormal_cell_migration0.65904392
130MP0000716_abnormal_immune_system0.64899878
131MP0001666_abnormal_nutrient_absorption0.63805893
132MP0005666_abnormal_adipose_tissue0.63713073
133MP0002269_muscular_atrophy0.63247925
134MP0004133_heterotaxia0.63182230
135MP0009115_abnormal_fat_cell0.60344184
136MP0002429_abnormal_blood_cell0.59213296
137MP0001188_hyperpigmentation0.58153360
138MP0000631_abnormal_neuroendocrine_gland0.57931286
139MP0009046_muscle_twitch0.54790544
140MP0010678_abnormal_skin_adnexa0.54203535
141MP0002970_abnormal_white_adipose0.53368295
142MP0000383_abnormal_hair_follicle0.52886532
143MP0005391_vision/eye_phenotype0.52830831
144MP0002837_dystrophic_cardiac_calcinosis0.52038758

Predicted human phenotypes

RankGene SetZ-score
1Cortical dysplasia (HP:0002539)4.24947532
2Papillary thyroid carcinoma (HP:0002895)3.87419783
3Chronic hepatic failure (HP:0100626)3.75168786
4Rhabdomyosarcoma (HP:0002859)3.74766311
5Medulloblastoma (HP:0002885)3.64818548
6Abnormality of the labia minora (HP:0012880)3.63788569
7Aplasia/Hypoplasia of the uvula (HP:0010293)3.42835279
8Ependymoma (HP:0002888)3.37335611
9Birth length less than 3rd percentile (HP:0003561)3.36175754
10Colon cancer (HP:0003003)3.29564330
11Abnormality of the fingertips (HP:0001211)3.17682220
12Meckel diverticulum (HP:0002245)3.13360964
13Abnormality of the ileum (HP:0001549)3.13319869
14Volvulus (HP:0002580)3.12132955
15Neoplasm of striated muscle (HP:0009728)3.08588079
16Chromsome breakage (HP:0040012)3.08381754
17Abnormality of DNA repair (HP:0003254)2.99492671
18Astrocytoma (HP:0009592)2.95252982
19Abnormality of the astrocytes (HP:0100707)2.95252982
20Neoplasm of the oral cavity (HP:0100649)2.94319334
21Clubbing of toes (HP:0100760)2.94078516
22Abnormality of the preputium (HP:0100587)2.93085926
23Progressive inability to walk (HP:0002505)2.88787031
24Shawl scrotum (HP:0000049)2.86315169
25Hypochromic microcytic anemia (HP:0004840)2.84029012
26Sandal gap (HP:0001852)2.82607656
27Deep venous thrombosis (HP:0002625)2.79899865
28Facial hemangioma (HP:0000329)2.78393479
29Aplasia/Hypoplasia of the tibia (HP:0005772)2.76057718
30Small intestinal stenosis (HP:0012848)2.73569474
31Duodenal stenosis (HP:0100867)2.73569474
32Biliary tract neoplasm (HP:0100574)2.71668516
33Embryonal renal neoplasm (HP:0011794)2.70444721
34Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.67941975
35Short 4th metacarpal (HP:0010044)2.67941975
36Impulsivity (HP:0100710)2.61807149
37Chromosomal breakage induced by crosslinking agents (HP:0003221)2.61425412
38Intrahepatic cholestasis (HP:0001406)2.49705155
39Male infertility (HP:0003251)2.47260605
40Ectopic kidney (HP:0000086)2.45217190
41Aplasia/Hypoplasia of the sternum (HP:0006714)2.44693923
42Abnormality of the carotid arteries (HP:0005344)2.41605355
43Abnormality of chromosome stability (HP:0003220)2.41373248
44Gastrointestinal carcinoma (HP:0002672)2.39575953
45Malignant gastrointestinal tract tumors (HP:0006749)2.39575953
46Prominent nose (HP:0000448)2.37582904
47Abnormal biliary tract morphology (HP:0012440)2.37028761
48Renal cortical cysts (HP:0000803)2.35739471
49Tubulointerstitial nephritis (HP:0001970)2.35210511
50Heterotopia (HP:0002282)2.34370375
51Oligodactyly (hands) (HP:0001180)2.29443524
52Myelodysplasia (HP:0002863)2.28614096
53Glioma (HP:0009733)2.28579178
54Long eyelashes (HP:0000527)2.27579728
55Short tibia (HP:0005736)2.27222535
56Attenuation of retinal blood vessels (HP:0007843)2.26268198
57Abnormality of the duodenum (HP:0002246)2.25712567
58Breast hypoplasia (HP:0003187)2.23915600
59IgA deficiency (HP:0002720)2.22215884
60Abnormality of the pons (HP:0007361)2.22039937
61Acute myeloid leukemia (HP:0004808)2.21017514
62Cafe-au-lait spot (HP:0000957)2.20109080
63Carpal bone hypoplasia (HP:0001498)2.19506419
64Abnormality of the renal cortex (HP:0011035)2.15303127
65Poikiloderma (HP:0001029)2.15230015
66Hypoplasia of the pons (HP:0012110)2.13811178
67Basal cell carcinoma (HP:0002671)2.12809160
68Abnormality of the 4th metacarpal (HP:0010012)2.08477503
69Hyperglycemia (HP:0003074)2.07029422
70Overlapping toe (HP:0001845)2.05747436
71Hypobetalipoproteinemia (HP:0003563)2.04171012
72Oligodactyly (HP:0012165)2.04113371
73Agnosia (HP:0010524)2.03629999
74Cerebellar dysplasia (HP:0007033)2.03300889
75Aplasia/Hypoplasia of the earlobes (HP:0009906)2.02977367
76Patellar aplasia (HP:0006443)2.02602127
77Sparse lateral eyebrow (HP:0005338)2.01964044
78Abnormality of chromosome segregation (HP:0002916)2.00219662
79Pancreatic cysts (HP:0001737)2.00169564
80IgG deficiency (HP:0004315)1.99843680
81Protruding tongue (HP:0010808)1.98679281
82Thyroid carcinoma (HP:0002890)1.98677938
83IgM deficiency (HP:0002850)1.96766659
84Hepatoblastoma (HP:0002884)1.96105422
85Hypoplastic labia majora (HP:0000059)1.95903854
86Abnormal lung lobation (HP:0002101)1.95600216
87Delayed puberty (HP:0000823)1.93908525
88Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.92986918
89Pancreatic fibrosis (HP:0100732)1.92784895
90Duplicated collecting system (HP:0000081)1.92213316
91Gaze-evoked nystagmus (HP:0000640)1.91676262
92Pseudobulbar signs (HP:0002200)1.91368522
93Astigmatism (HP:0000483)1.90611001
94Transitional cell carcinoma of the bladder (HP:0006740)1.90093751
95Urethral obstruction (HP:0000796)1.89454165
96Broad thumb (HP:0011304)1.88041187
97Deviation of the thumb (HP:0009603)1.87922727
98Abnormality of the renal collecting system (HP:0004742)1.87639533
99Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.87456059
100Short 1st metacarpal (HP:0010034)1.87456059
101Truncal obesity (HP:0001956)1.87354103
102Panhypogammaglobulinemia (HP:0003139)1.87336036
103Neoplasm of the adrenal cortex (HP:0100641)1.86664783
104Nephronophthisis (HP:0000090)1.86347556
105Acute lymphatic leukemia (HP:0006721)1.86200729
106Lissencephaly (HP:0001339)1.85776889
107Subacute progressive viral hepatitis (HP:0006572)1.85398160
108Genetic anticipation (HP:0003743)1.84311676
109Hypopigmentation of the fundus (HP:0007894)1.83927966
110Embryonal neoplasm (HP:0002898)1.83780165
111Absent forearm bone (HP:0003953)1.82415233
112Anal stenosis (HP:0002025)1.81625075
113Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.81562251
114Abnormality of alanine metabolism (HP:0010916)1.81562251
115Hyperalaninemia (HP:0003348)1.81562251
116Abnormality of sulfur amino acid metabolism (HP:0004339)1.81539846
117Inability to walk (HP:0002540)1.80575429
118Abnormality of monocarboxylic acid metabolism (HP:0010996)1.80240816
119Rib fusion (HP:0000902)1.79944054
120Uterine neoplasm (HP:0010784)1.79012745
121Bony spicule pigmentary retinopathy (HP:0007737)1.78898302
122Abnormality of the labia majora (HP:0012881)1.78344620
123Aplasia/Hypoplasia of the patella (HP:0006498)1.78278054
124Acanthocytosis (HP:0001927)1.77826148
125Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.77480203
126Narrow palate (HP:0000189)1.77223067
127Abnormality of midbrain morphology (HP:0002418)1.76226817
128Molar tooth sign on MRI (HP:0002419)1.76226817
129Absent radius (HP:0003974)1.75632061
130Leiomyosarcoma (HP:0100243)1.74284358
131Uterine leiomyosarcoma (HP:0002891)1.74284358
132Premature ovarian failure (HP:0008209)1.74276050
133Proximal placement of thumb (HP:0009623)1.74146246
134Deep philtrum (HP:0002002)1.71986886
135Neoplasm of the small intestine (HP:0100833)1.71544209
136Flat capital femoral epiphysis (HP:0003370)1.71118989
137Postaxial foot polydactyly (HP:0001830)1.71024963
138Abnormality of pyrimidine metabolism (HP:0004353)1.70955203
139Sloping forehead (HP:0000340)1.69524479
140Neoplasm of the liver (HP:0002896)1.69441960
141Hepatocellular carcinoma (HP:0001402)1.69334811
142Short phalanx of the thumb (HP:0009660)1.69323553
143Metaphyseal cupping (HP:0003021)1.68938025
144Increased nuchal translucency (HP:0010880)1.68507264
145Hypolipoproteinemia (HP:0010981)1.66885523
146Poor coordination (HP:0002370)1.66107616
147Supernumerary spleens (HP:0009799)1.65336105
148Nephroblastoma (Wilms tumor) (HP:0002667)1.65268461
149Bladder carcinoma (HP:0002862)1.65121010
150Bladder neoplasm (HP:0009725)1.65121010
151B lymphocytopenia (HP:0010976)1.64458164
152Clitoromegaly (HP:0000057)1.63765373
153Broad palm (HP:0001169)1.63748954
154Hypoplasia of the thymus (HP:0000778)1.62328996
155Intestinal polyp (HP:0005266)1.61272496
156Arteriovenous malformation (HP:0100026)1.60863034
157Abnormal spermatogenesis (HP:0008669)1.60159527
158Abnormality of the renal medulla (HP:0100957)1.59747114
159Abnormality of T cell physiology (HP:0011840)1.59661969
160Cubitus valgus (HP:0002967)1.59632183
161Recurrent viral infections (HP:0004429)1.59213798
162Aplasia involving forearm bones (HP:0009822)1.58955723
163Sensory axonal neuropathy (HP:0003390)1.57939587
164Low anterior hairline (HP:0000294)1.57553689
165Short thumb (HP:0009778)1.56390390
166Oligohydramnios (HP:0001562)1.56143066
167Fibular aplasia (HP:0002990)1.55380498
168True hermaphroditism (HP:0010459)1.54992713
169Absent thumb (HP:0009777)1.54619773
170Preaxial hand polydactyly (HP:0001177)1.54295003
171Progressive cerebellar ataxia (HP:0002073)1.54208073

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.58968196
2CDC74.39289296
3LATS13.71589462
4TTK2.84719118
5ZAK2.75721137
6MAP4K22.72221067
7MKNK12.69000926
8EIF2AK32.67708513
9STK102.41360361
10MKNK22.34230628
11NEK22.11627827
12EEF2K2.09874926
13TAOK32.07965943
14MAP3K62.00391939
15TRIM281.95869989
16LATS21.93683785
17ACVR1B1.89128283
18STK38L1.87190602
19AKT31.76479768
20MELK1.69335539
21WEE11.63486273
22CHEK21.59246105
23BRD41.58678533
24FRK1.56043721
25NEK11.52648943
26PLK11.51329743
27PLK41.49952925
28STK31.46862599
29TAF11.43771216
30ERBB31.43081860
31TLK11.41482998
32CHEK11.39479422
33NUAK11.34973069
34MAP3K81.34233354
35ERBB41.33217929
36MAP3K141.33152762
37MAP3K91.32898037
38TNIK1.32743593
39CAMK1D1.32228681
40CDK91.28194805
41MAP3K41.24347521
42MTOR1.22722519
43ATM1.22204288
44CDK41.18194898
45ATR1.17453907
46CDK61.17424431
47TSSK61.15205703
48KSR21.14441188
49TEC1.14359327
50AURKB1.12238386
51MAP3K101.11629485
52RPS6KB21.08936922
53PLK31.06849578
54PASK1.05708089
55PNCK1.01369779
56BMPR1B1.00554917
57PDK40.98001682
58PDK30.98001682
59CCNB10.97873305
60FGFR40.96105472
61PINK10.95857644
62MOS0.93450049
63MAP3K130.93251553
64EIF2AK10.93180425
65FGFR20.92982163
66NEK60.91570033
67CDK70.90544877
68CDK20.90462139
69SCYL20.88720966
70VRK10.88578780
71BRSK20.88534805
72RAF10.88387768
73INSRR0.86844091
74WNK10.86391103
75SRPK10.84978736
76MAP2K70.82708430
77EIF2AK20.82474344
78PKN20.80970326
79IKBKE0.80922430
80PRKD30.80260173
81KSR10.80229797
82PDK20.79296988
83RPS6KA50.79005218
84ALK0.77580458
85RPS6KA40.77552130
86CAMK1G0.77399915
87RET0.74409497
88WNK40.73617961
89CDK10.72826944
90WNK30.71558952
91BMPR20.70971385
92SIK20.70696690
93CDK30.70012472
94FGFR30.69964116
95STK40.69752144
96CSNK1D0.68481982
97FLT30.67400034
98PRKCQ0.65361173
99SGK30.64583006
100PRKAA10.63873187
101BUB10.63196902
102TRIB30.61355251
103SGK20.61141428
104PLK20.60853751
105CAMKK20.60191604
106TNK20.59940047
107DMPK0.57436927
108BTK0.57411357
109PBK0.57359986
110FGFR10.56999479
111SIK10.55840828
112CSNK1A1L0.55402047
113BRAF0.54428062
114TXK0.53830625
115BCR0.53752465
116NLK0.52942699
117PRKDC0.52473653
118PIM10.52338983
119PRKAA20.51828634
120PTK60.51626328
121TGFBR10.51321574
122LRRK20.51137231
123JAK30.50938737
124MAPK140.47694886
125STK380.47309540
126SYK0.47177479
127CSNK1E0.46746050
128RPS6KB10.46361987
129MAP2K20.44471406
130MET0.44279370
131GSK3B0.43762858
132TYRO30.43040039
133MARK30.41721051
134PDGFRB0.40634765
135DYRK30.39965912
136CSNK1G10.39918529
137EPHA20.39182667
138MAPK10.38873110
139MAP4K10.38194826
140MAPK100.37869900
141MAPK110.37294834
142STK390.36597755
143SGK4940.36252280
144SGK2230.36252280

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.85008147
2Cell cycle_Homo sapiens_hsa041102.82092598
3Non-homologous end-joining_Homo sapiens_hsa034502.72283715
4One carbon pool by folate_Homo sapiens_hsa006702.63552063
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.60559920
6RNA transport_Homo sapiens_hsa030132.52691566
7Mismatch repair_Homo sapiens_hsa034302.34548857
8Selenocompound metabolism_Homo sapiens_hsa004502.21044547
9Lysine degradation_Homo sapiens_hsa003102.19811049
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.19641577
11DNA replication_Homo sapiens_hsa030302.07063318
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.05567079
13RNA degradation_Homo sapiens_hsa030182.04143477
14Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.93650713
15Primary immunodeficiency_Homo sapiens_hsa053401.93085742
16Fanconi anemia pathway_Homo sapiens_hsa034601.88910314
17mRNA surveillance pathway_Homo sapiens_hsa030151.78914546
18Arginine biosynthesis_Homo sapiens_hsa002201.75914151
19Basal transcription factors_Homo sapiens_hsa030221.66284460
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.59250500
21Primary bile acid biosynthesis_Homo sapiens_hsa001201.57992579
22Homologous recombination_Homo sapiens_hsa034401.54501213
23Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.54361781
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.52178135
25Base excision repair_Homo sapiens_hsa034101.49473454
26MicroRNAs in cancer_Homo sapiens_hsa052061.48686716
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.45919026
28Dorso-ventral axis formation_Homo sapiens_hsa043201.45378438
29Oocyte meiosis_Homo sapiens_hsa041141.42125382
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.39886644
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.34773735
32Cyanoamino acid metabolism_Homo sapiens_hsa004601.34417919
33Systemic lupus erythematosus_Homo sapiens_hsa053221.33292912
34Nucleotide excision repair_Homo sapiens_hsa034201.31184407
35mTOR signaling pathway_Homo sapiens_hsa041501.30853686
36p53 signaling pathway_Homo sapiens_hsa041151.29520800
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.28617839
38Biosynthesis of amino acids_Homo sapiens_hsa012301.23483541
39Spliceosome_Homo sapiens_hsa030401.18889436
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.17315237
41Olfactory transduction_Homo sapiens_hsa047401.04656550
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.04028274
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.02597407
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00526900
45Viral carcinogenesis_Homo sapiens_hsa052031.00205489
46TGF-beta signaling pathway_Homo sapiens_hsa043500.99644171
47Asthma_Homo sapiens_hsa053100.98555013
48Adherens junction_Homo sapiens_hsa045200.95547496
49Butanoate metabolism_Homo sapiens_hsa006500.95362104
50Pancreatic cancer_Homo sapiens_hsa052120.94765120
51B cell receptor signaling pathway_Homo sapiens_hsa046620.91352620
52Complement and coagulation cascades_Homo sapiens_hsa046100.87406067
53Phototransduction_Homo sapiens_hsa047440.86358783
54Glucagon signaling pathway_Homo sapiens_hsa049220.86154803
55NF-kappa B signaling pathway_Homo sapiens_hsa040640.86131590
56Regulation of autophagy_Homo sapiens_hsa041400.85943237
57Colorectal cancer_Homo sapiens_hsa052100.85092465
58Small cell lung cancer_Homo sapiens_hsa052220.85006765
59Allograft rejection_Homo sapiens_hsa053300.84666410
60FoxO signaling pathway_Homo sapiens_hsa040680.83792489
61T cell receptor signaling pathway_Homo sapiens_hsa046600.83704106
62Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81832841
63Prostate cancer_Homo sapiens_hsa052150.81799827
64Purine metabolism_Homo sapiens_hsa002300.80869435
65Autoimmune thyroid disease_Homo sapiens_hsa053200.77504446
66Tryptophan metabolism_Homo sapiens_hsa003800.77132261
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.76845403
68Insulin resistance_Homo sapiens_hsa049310.75031181
69Bile secretion_Homo sapiens_hsa049760.74034397
70Hepatitis B_Homo sapiens_hsa051610.73959763
71HTLV-I infection_Homo sapiens_hsa051660.73015454
72Vitamin B6 metabolism_Homo sapiens_hsa007500.71145146
73Endometrial cancer_Homo sapiens_hsa052130.70838855
74Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70771446
75Maturity onset diabetes of the young_Homo sapiens_hsa049500.70404299
762-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.70166767
77Fatty acid biosynthesis_Homo sapiens_hsa000610.69676744
78Measles_Homo sapiens_hsa051620.69259528
79Thyroid cancer_Homo sapiens_hsa052160.68914264
80RNA polymerase_Homo sapiens_hsa030200.68787605
81Apoptosis_Homo sapiens_hsa042100.68483483
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68134296
83Circadian rhythm_Homo sapiens_hsa047100.67687252
84AMPK signaling pathway_Homo sapiens_hsa041520.67382778
85Ovarian steroidogenesis_Homo sapiens_hsa049130.67051563
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64713067
87Hippo signaling pathway_Homo sapiens_hsa043900.64686122
88Taste transduction_Homo sapiens_hsa047420.64573345
89Chronic myeloid leukemia_Homo sapiens_hsa052200.63178053
90Fatty acid degradation_Homo sapiens_hsa000710.62948123
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62415958
92Influenza A_Homo sapiens_hsa051640.61027361
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60784323
94Epstein-Barr virus infection_Homo sapiens_hsa051690.60668236
95Non-small cell lung cancer_Homo sapiens_hsa052230.59521445
96Graft-versus-host disease_Homo sapiens_hsa053320.58934146
97Antigen processing and presentation_Homo sapiens_hsa046120.58377456
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.57169570
99Type I diabetes mellitus_Homo sapiens_hsa049400.57029035
100Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56788002
101Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55364997
102PPAR signaling pathway_Homo sapiens_hsa033200.54182373
103Herpes simplex infection_Homo sapiens_hsa051680.53776235
104Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.53731356
105NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51548705
106Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50625199
107Viral myocarditis_Homo sapiens_hsa054160.50279280
108Choline metabolism in cancer_Homo sapiens_hsa052310.49379972
109Propanoate metabolism_Homo sapiens_hsa006400.47690966
110Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.46235179
111Pyruvate metabolism_Homo sapiens_hsa006200.45341853
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45017032
113Drug metabolism - other enzymes_Homo sapiens_hsa009830.44866104
114Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44399453
115Prolactin signaling pathway_Homo sapiens_hsa049170.44331132
116Insulin signaling pathway_Homo sapiens_hsa049100.43085524
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.42481806
118Inositol phosphate metabolism_Homo sapiens_hsa005620.42065353
119Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41770749
120Ether lipid metabolism_Homo sapiens_hsa005650.40334752
121Renal cell carcinoma_Homo sapiens_hsa052110.40219735
122Jak-STAT signaling pathway_Homo sapiens_hsa046300.39066380
123Fat digestion and absorption_Homo sapiens_hsa049750.38882125
124alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38870069
125Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38232840
126Steroid biosynthesis_Homo sapiens_hsa001000.38130379
127Estrogen signaling pathway_Homo sapiens_hsa049150.38000390
128Notch signaling pathway_Homo sapiens_hsa043300.36840874
129Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.36782095
130Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36557084
131Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.35912304
132Carbon metabolism_Homo sapiens_hsa012000.34600500
133Fatty acid metabolism_Homo sapiens_hsa012120.33522101
134Pyrimidine metabolism_Homo sapiens_hsa002400.33329668
135Glycerolipid metabolism_Homo sapiens_hsa005610.33200416
136Alcoholism_Homo sapiens_hsa050340.32804270
137Basal cell carcinoma_Homo sapiens_hsa052170.31911770
138ABC transporters_Homo sapiens_hsa020100.31870866
139Linoleic acid metabolism_Homo sapiens_hsa005910.31759734
140Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.31465761
141Long-term depression_Homo sapiens_hsa047300.27976837
142Melanoma_Homo sapiens_hsa052180.27106449
143Hedgehog signaling pathway_Homo sapiens_hsa043400.25149517

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