EDN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of branching involved in prostate gland morphogenesis (GO:0060687)7.33803198
2mesenchymal-epithelial cell signaling (GO:0060638)6.68392892
3lateral sprouting from an epithelium (GO:0060601)6.57682386
4regulation of branching involved in salivary gland morphogenesis (GO:0060693)6.18349936
5negative regulation of JUN kinase activity (GO:0043508)6.01499013
6branching involved in labyrinthine layer morphogenesis (GO:0060670)5.91777986
7prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060525.88688895
8regulation of non-canonical Wnt signaling pathway (GO:2000050)5.56328033
9regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)5.51435012
10cell proliferation involved in kidney development (GO:0072111)5.25690527
11cell proliferation involved in metanephros development (GO:0072203)5.15681417
12radial glial cell differentiation (GO:0060019)5.11008888
13regulation of type B pancreatic cell apoptotic process (GO:2000674)5.07274863
14endocrine pancreas development (GO:0031018)4.97374224
15negative regulation of catenin import into nucleus (GO:0035414)4.96567345
16angiotensin maturation (GO:0002003)4.70622486
17planar cell polarity pathway involved in neural tube closure (GO:0090179)4.63004180
18craniofacial suture morphogenesis (GO:0097094)4.62424557
19cellular response to vitamin D (GO:0071305)4.58265366
20mesenchymal cell proliferation (GO:0010463)4.53189262
21branching involved in salivary gland morphogenesis (GO:0060445)4.51523679
22insulin secretion (GO:0030073)4.46067531
23regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.38981775
24negative regulation of osteoblast proliferation (GO:0033689)4.34252503
25regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.31844541
26negative regulation of hormone biosynthetic process (GO:0032353)4.29325883
27genitalia morphogenesis (GO:0035112)4.28872241
28somite development (GO:0061053)4.26430122
29keratinocyte proliferation (GO:0043616)4.18811831
30regulation of bile acid biosynthetic process (GO:0070857)4.15633237
31convergent extension (GO:0060026)4.14990563
32branching involved in prostate gland morphogenesis (GO:0060442)4.13477328
33type B pancreatic cell development (GO:0003323)4.13012155
34nitric oxide mediated signal transduction (GO:0007263)4.12873199
35positive regulation of glycolytic process (GO:0045821)4.12481707
36peptide hormone processing (GO:0016486)4.06292085
37negative regulation of hormone metabolic process (GO:0032351)4.03831035
38bone trabecula formation (GO:0060346)4.01643888
39dorsal/ventral axis specification (GO:0009950)3.82491952
40regulation of protein glycosylation (GO:0060049)3.78921620
41glandular epithelial cell development (GO:0002068)3.78049213
42digestive tract morphogenesis (GO:0048546)3.77540894
43positive regulation of respiratory burst (GO:0060267)3.77431290
44Golgi transport vesicle coating (GO:0048200)3.76686176
45COPI coating of Golgi vesicle (GO:0048205)3.76686176
46kidney morphogenesis (GO:0060993)3.73803216
47mesenchymal cell differentiation (GO:0048762)3.67243599
48positive regulation of glycoprotein biosynthetic process (GO:0010560)3.66274934
49pharyngeal system development (GO:0060037)3.62830448
50regulation of guanylate cyclase activity (GO:0031282)3.59526208
51otic vesicle formation (GO:0030916)3.59419996
52neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.59043607
53glycerophospholipid catabolic process (GO:0046475)3.58690173
54macroautophagy (GO:0016236)3.58507544
55regulation of keratinocyte proliferation (GO:0010837)3.55790551
56branch elongation of an epithelium (GO:0060602)3.53729961
57sequestering of extracellular ligand from receptor (GO:0035581)3.51959193
58regulation of cholesterol homeostasis (GO:2000188)3.51654953
59cellular response to prostaglandin stimulus (GO:0071379)3.48734704
60renal system development (GO:0072001)3.47829618
61negative regulation of multicellular organism growth (GO:0040015)3.39671413
62intestinal absorption (GO:0050892)3.37673926
63axis elongation (GO:0003401)3.37559327
64negative regulation of protein oligomerization (GO:0032460)3.33389613
65Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.31572948
66fructose metabolic process (GO:0006000)3.31250311
67regulation of energy homeostasis (GO:2000505)3.31113801
68phenylpropanoid metabolic process (GO:0009698)3.30760154
69NADH metabolic process (GO:0006734)3.27984402
70regulation of lipoprotein metabolic process (GO:0050746)3.26945151
71* peptide hormone secretion (GO:0030072)3.24394081
72positive regulation of insulin secretion (GO:0032024)3.24230886
73cranial suture morphogenesis (GO:0060363)3.23302700
74regulation of establishment of planar polarity (GO:0090175)3.22665015
75energy homeostasis (GO:0097009)3.19707863
76epoxygenase P450 pathway (GO:0019373)3.19515925
77epithelial cell fate commitment (GO:0072148)3.19246678
78auditory receptor cell differentiation (GO:0042491)3.17050387
79sphingomyelin metabolic process (GO:0006684)3.16989721
80positive regulation of peptidyl-threonine phosphorylation (GO:0010800)3.16491122
81L-alpha-amino acid transmembrane transport (GO:1902475)3.14769160
82cellular response to vitamin (GO:0071295)3.12200277
83positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.11978218
84cellular response to cholesterol (GO:0071397)3.11708790
85hindlimb morphogenesis (GO:0035137)3.10504585
86gland morphogenesis (GO:0022612)3.10093325
87* peptide secretion (GO:0002790)3.10036826
88hair follicle morphogenesis (GO:0031069)3.09070626
89regulation of glucocorticoid metabolic process (GO:0031943)3.08905464
90proximal/distal pattern formation (GO:0009954)3.07922863
91positive regulation of glycoprotein metabolic process (GO:1903020)3.07467899
92positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.06184750
93columnar/cuboidal epithelial cell development (GO:0002066)3.06080083
94endothelial cell differentiation (GO:0045446)3.04112560
95positive regulation of peptide hormone secretion (GO:0090277)3.01999970
96prostate gland epithelium morphogenesis (GO:0060740)3.01990185
97* peptide transport (GO:0015833)3.01858319
98glandular epithelial cell differentiation (GO:0002067)2.99997710
99non-canonical Wnt signaling pathway (GO:0035567)2.99845719
100organ formation (GO:0048645)2.99252053
101cellular zinc ion homeostasis (GO:0006882)2.95896260
102epithelial tube branching involved in lung morphogenesis (GO:0060441)2.95450051
103phenol-containing compound catabolic process (GO:0019336)2.94322977
104negative regulation of gluconeogenesis (GO:0045721)2.92731314
105regulation of morphogenesis of a branching structure (GO:0060688)2.92329678
106positive regulation of peptide secretion (GO:0002793)2.91853110
107nucleoside diphosphate catabolic process (GO:0009134)2.91408218
108* regulation of systemic arterial blood pressure by hormone (GO:0001990)2.91049657
109* regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.91049657
110* endocrine process (GO:0050886)2.91049657
111detection of calcium ion (GO:0005513)2.89002431
112NLS-bearing protein import into nucleus (GO:0006607)2.88856664
113positive regulation of guanylate cyclase activity (GO:0031284)2.88838291
114regulation of osteoblast proliferation (GO:0033688)2.87792692
115regulation of autophagic vacuole assembly (GO:2000785)2.87734432
116response to follicle-stimulating hormone (GO:0032354)2.86267137
117regulation of insulin secretion (GO:0050796)2.84658236
118organ induction (GO:0001759)2.83874438
119limb bud formation (GO:0060174)2.83730039
120heart field specification (GO:0003128)2.83722675
121secondary heart field specification (GO:0003139)2.83722675
122positive regulation of response to nutrient levels (GO:0032109)2.82949291
123positive regulation of response to extracellular stimulus (GO:0032106)2.82949291
124trabecula formation (GO:0060343)2.82932967
125negative regulation of osteoblast differentiation (GO:0045668)2.82686792
126vitamin A metabolic process (GO:0006776)2.80215708
127lactate metabolic process (GO:0006089)2.80105626
128sphingolipid catabolic process (GO:0030149)2.79553940
129proline transport (GO:0015824)2.79389501
130embryonic hindlimb morphogenesis (GO:0035116)2.77428817
131cardiac left ventricle morphogenesis (GO:0003214)2.77087411
132organ growth (GO:0035265)2.76909120
133positive regulation of hormone biosynthetic process (GO:0046886)2.75640136
134regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.74561875
135membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.74171421
136neuronal ion channel clustering (GO:0045161)2.74049032
137cellular ketone body metabolic process (GO:0046950)2.73915851
138intestinal epithelial cell development (GO:0060576)2.73732093
139negative regulation of Ras GTPase activity (GO:0034261)2.72641333
140glycine transport (GO:0015816)2.72551003
141negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.72511324
142embryonic retina morphogenesis in camera-type eye (GO:0060059)2.71432482
143glomerular basement membrane development (GO:0032836)2.71171689
144regulation of extracellular matrix disassembly (GO:0010715)2.70970081
145response to prostaglandin E (GO:0034695)2.70173708
146regulation of catenin import into nucleus (GO:0035412)2.69959078
147vascular endothelial growth factor signaling pathway (GO:0038084)2.69816223
148very-low-density lipoprotein particle assembly (GO:0034379)2.69634365
149regulation of smoothened signaling pathway (GO:0008589)2.69240936
150negative regulation of JNK cascade (GO:0046329)2.69172241
151negative regulation of glycogen metabolic process (GO:0070874)2.67475035
152negative regulation of smoothened signaling pathway (GO:0045879)2.67114536
153protein localization to cell surface (GO:0034394)2.66518303
154pattern specification involved in kidney development (GO:0061004)2.66053686
155Golgi to endosome transport (GO:0006895)2.65280535
156negative regulation of acute inflammatory response (GO:0002674)2.65214373
157lung epithelium development (GO:0060428)2.64374995
158protein targeting to plasma membrane (GO:0072661)2.63035012
159digestion (GO:0007586)2.62970908
160mesodermal cell differentiation (GO:0048333)2.62000752
161positive regulation of vasodilation (GO:0045909)2.60031938
162* amide transport (GO:0042886)2.60001430
163regulation of glucokinase activity (GO:0033131)2.59415846
164regulation of hexokinase activity (GO:1903299)2.59415846
165fat-soluble vitamin biosynthetic process (GO:0042362)2.58641129
166mammary gland epithelial cell differentiation (GO:0060644)2.57780259
167zinc ion homeostasis (GO:0055069)2.57435284
168regulation of peptide hormone secretion (GO:0090276)2.56857839
169nitric oxide biosynthetic process (GO:0006809)2.56557937
170outflow tract septum morphogenesis (GO:0003148)2.55503897
171transcytosis (GO:0045056)2.55238152
172COPII vesicle coating (GO:0048208)2.54330734
173positive regulation of macroautophagy (GO:0016239)2.53290669
174regulation of pigment cell differentiation (GO:0050932)2.52867594
175membrane lipid catabolic process (GO:0046466)2.52559610
176regulation of peptide secretion (GO:0002791)2.51465058
177exocrine pancreas development (GO:0031017)2.51398537
178inositol phosphate catabolic process (GO:0071545)2.50790329
179signal peptide processing (GO:0006465)2.49899323
180* hormone secretion (GO:0046879)2.49274233
181regulation of glycolytic process (GO:0006110)2.48708852
182regulation of steroid hormone biosynthetic process (GO:0090030)2.48664831
183regulation of gluconeogenesis (GO:0006111)2.48453452
184succinate metabolic process (GO:0006105)2.48257684
185drug metabolic process (GO:0017144)2.47103473
186retinol metabolic process (GO:0042572)2.44879005
187positive regulation of glycogen biosynthetic process (GO:0045725)2.44734501
188inositol phosphate dephosphorylation (GO:0046855)2.42171922
189phosphorylated carbohydrate dephosphorylation (GO:0046838)2.42171922
190phospholipid catabolic process (GO:0009395)2.42112380
191regulation of vacuole organization (GO:0044088)2.41022976

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.26002065
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.71836661
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.34404969
4ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.78511667
5TRIM28_21343339_ChIP-Seq_HEK293_Human2.64514703
6EED_16625203_ChIP-ChIP_MESCs_Mouse2.32999591
7IKZF1_21737484_ChIP-ChIP_HCT116_Human2.18581032
8SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.13189355
9* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.12581210
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.05537981
11ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.01122626
12VDR_22108803_ChIP-Seq_LS180_Human1.97237194
13PIAS1_25552417_ChIP-Seq_VCAP_Human1.92513948
14BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.91049023
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.90558611
16RBPJ_22232070_ChIP-Seq_NCS_Mouse1.89387922
17* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.88948016
18* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.88637141
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.88604480
20* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.87496060
21EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.87005924
22GBX2_23144817_ChIP-Seq_PC3_Human1.82071129
23POU3F2_20337985_ChIP-ChIP_501MEL_Human1.80989497
24EZH2_18974828_ChIP-Seq_MESCs_Mouse1.78669095
25RNF2_18974828_ChIP-Seq_MESCs_Mouse1.78669095
26PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.75732758
27EZH2_27304074_Chip-Seq_ESCs_Mouse1.74009317
28* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.73335808
29CDX2_19796622_ChIP-Seq_MESCs_Mouse1.69066793
30JARID2_20064375_ChIP-Seq_MESCs_Mouse1.68779576
31EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.68681710
32JARID2_20075857_ChIP-Seq_MESCs_Mouse1.67459534
33RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.67109632
34TP63_19390658_ChIP-ChIP_HaCaT_Human1.63828158
35EP300_21415370_ChIP-Seq_HL-1_Mouse1.56925018
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.56006112
37ISL1_27105846_Chip-Seq_CPCs_Mouse1.54360789
38RNF2_27304074_Chip-Seq_ESCs_Mouse1.48713943
39BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.45999545
40AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.45454984
41SOX2_20726797_ChIP-Seq_SW620_Human1.44369999
42* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.43860837
43CDX2_22108803_ChIP-Seq_LS180_Human1.43556585
44HTT_18923047_ChIP-ChIP_STHdh_Human1.42807417
45* SMAD4_21799915_ChIP-Seq_A2780_Human1.42216933
46* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.42135549
47WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.41514608
48AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.40102235
49AHR_22903824_ChIP-Seq_MCF-7_Human1.39996589
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.39500182
51STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.38697887
52SUZ12_27294783_Chip-Seq_ESCs_Mouse1.38024875
53FOXA1_25552417_ChIP-Seq_VCAP_Human1.37754584
54FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.37528723
55WT1_19549856_ChIP-ChIP_CCG9911_Human1.36629613
56HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.35905536
57AR_21572438_ChIP-Seq_LNCaP_Human1.33665585
58NR3C1_23031785_ChIP-Seq_PC12_Mouse1.33059448
59CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.32703013
60CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.32170458
61MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32017713
62* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.31173796
63SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31113564
64* NANOG_18555785_Chip-Seq_ESCs_Mouse1.30748191
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30662917
66NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.29961685
67* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29720726
68DROSHA_22980978_ChIP-Seq_HELA_Human1.29227372
69P300_19829295_ChIP-Seq_ESCs_Human1.29226119
70ESR1_21235772_ChIP-Seq_MCF-7_Human1.29194353
71ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28869421
72TBX3_20139965_ChIP-Seq_MESCs_Mouse1.28554115
73GATA1_22025678_ChIP-Seq_K562_Human1.27644826
74BMI1_23680149_ChIP-Seq_NPCS_Mouse1.27195513
75SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26620287
76TBX3_20139965_ChIP-Seq_ESCs_Mouse1.26597676
77* P53_22387025_ChIP-Seq_ESCs_Mouse1.26462507
78BCAT_22108803_ChIP-Seq_LS180_Human1.25791039
79NFE2_27457419_Chip-Seq_LIVER_Mouse1.25399581
80GATA4_25053715_ChIP-Seq_YYC3_Human1.24743848
81EZH2_27294783_Chip-Seq_ESCs_Mouse1.24424493
82NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24226127
83TP53_18474530_ChIP-ChIP_U2OS_Human1.24138409
84OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24072962
85DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.23905880
86TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.23846449
87AR_25329375_ChIP-Seq_VCAP_Human1.23352535
88* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.21786347
89TCF4_18268006_ChIP-ChIP_LS174T_Human1.21525576
90ARNT_22903824_ChIP-Seq_MCF-7_Human1.19935159
91* CMYC_18555785_Chip-Seq_ESCs_Mouse1.19843086
92RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.19591625
93PCGF2_27294783_Chip-Seq_ESCs_Mouse1.18602037
94RXR_22108803_ChIP-Seq_LS180_Human1.18418224
95GATA2_21666600_ChIP-Seq_HMVEC_Human1.17788130
96SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17129882
97* LXR_22158963_ChIP-Seq_LIVER_Mouse1.17100410
98* SOX2_21211035_ChIP-Seq_LN229_Gbm1.16995605
99FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16221594
100YAP1_20516196_ChIP-Seq_MESCs_Mouse1.16084582
101SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.15228763
102VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14520491
103ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.14500649
104CTBP1_25329375_ChIP-Seq_LNCAP_Human1.14358027
105* STAT3_18555785_Chip-Seq_ESCs_Mouse1.14308954
106EZH2_27294783_Chip-Seq_NPCs_Mouse1.13958904
107TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11544413
108* STAT3_23295773_ChIP-Seq_U87_Human1.11493874
109FOXO3_23340844_ChIP-Seq_DLD1_Human1.10722024
110SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10404343
111REST_21632747_ChIP-Seq_MESCs_Mouse1.10211017
112* SOX2_18555785_Chip-Seq_ESCs_Mouse1.10127917
113* CTCF_18555785_Chip-Seq_ESCs_Mouse1.09755124
114CTNNB1_20460455_ChIP-Seq_HCT116_Human1.08617551
115SMAD4_21741376_ChIP-Seq_HESCs_Human1.07656882
116CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07460419
117FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.07010769
118NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06700652
119NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06700652
120RXR_22158963_ChIP-Seq_LIVER_Mouse1.06644321
121* E2F1_18555785_Chip-Seq_ESCs_Mouse1.06004082
122CDX2_20551321_ChIP-Seq_CACO-2_Human1.05969274
123GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05719198
124* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.05416578
125KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.05010352
126KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.05010352
127KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.05010352
128TP53_16413492_ChIP-PET_HCT116_Human1.04975294
129CTBP2_25329375_ChIP-Seq_LNCAP_Human1.04403469
130RING1B_27294783_Chip-Seq_ESCs_Mouse1.04199923
131SMAD3_21741376_ChIP-Seq_HESCs_Human1.03391238
132TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.01215121
133NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.01140746
134* P300_18555785_Chip-Seq_ESCs_Mouse1.00382225
135CLOCK_20551151_ChIP-Seq_293T_Human1.00271999
136FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00229839
137ESR2_21235772_ChIP-Seq_MCF-7_Human0.99917891
138CBX2_27304074_Chip-Seq_ESCs_Mouse0.99574926
139RING1B_27294783_Chip-Seq_NPCs_Mouse0.98471486
140* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98004984
141* ESRRB_18555785_Chip-Seq_ESCs_Mouse0.97350416
142* ZFX_18555785_Chip-Seq_ESCs_Mouse0.96890901
143FOXA2_19822575_ChIP-Seq_HepG2_Human0.96494737
144* KLF4_18555785_Chip-Seq_ESCs_Mouse0.96474537
145ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.95852695
146FUS_26573619_Chip-Seq_HEK293_Human0.95697738
147* OCT4_18555785_Chip-Seq_ESCs_Mouse0.94575458
148NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.94382011
149SMAD3_21741376_ChIP-Seq_EPCs_Human0.93712693
150TP63_17297297_ChIP-ChIP_HaCaT_Human0.93580607
151POU5F1_16153702_ChIP-ChIP_HESCs_Human0.93571300
152* TCF4_22108803_ChIP-Seq_LS180_Human0.93411159
153* PU1_27457419_Chip-Seq_LIVER_Mouse0.93206411
154* SMAD1_18555785_Chip-Seq_ESCs_Mouse0.92575607
155TCF4_23295773_ChIP-Seq_U87_Human0.92369750

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004272_abnormal_basement_membrane3.94853165
2MP0005187_abnormal_penis_morphology3.92984345
3MP0002139_abnormal_hepatobiliary_system3.73102574
4MP0003011_delayed_dark_adaptation3.28668069
5MP0005503_abnormal_tendon_morphology3.28011667
6MP0000566_synostosis3.21791678
7MP0001299_abnormal_eye_distance/3.16738119
8MP0010234_abnormal_vibrissa_follicle3.15372046
9MP0010368_abnormal_lymphatic_system3.09512490
10MP0005257_abnormal_intraocular_pressure2.92281293
11MP0000013_abnormal_adipose_tissue2.86804318
12* MP0002938_white_spotting2.69187261
13MP0004019_abnormal_vitamin_homeostasis2.57799958
14MP0005360_urolithiasis2.56145936
15MP0005365_abnormal_bile_salt2.44864191
16MP0000003_abnormal_adipose_tissue2.42943834
17MP0003122_maternal_imprinting2.29953692
18MP0000428_abnormal_craniofacial_morphol2.29471349
19MP0005248_abnormal_Harderian_gland2.29353252
20MP0003183_abnormal_peptide_metabolism2.21007847
21MP0010329_abnormal_lipoprotein_level2.16139972
22MP0009250_abnormal_appendicular_skeleto2.10124875
23MP0000537_abnormal_urethra_morphology2.07265983
24MP0001661_extended_life_span2.06156291
25MP0010030_abnormal_orbit_morphology2.06073555
26MP0003942_abnormal_urinary_system2.05603706
27MP0005379_endocrine/exocrine_gland_phen2.03900598
28MP0004043_abnormal_pH_regulation2.01789453
29MP0002822_catalepsy1.99584791
30MP0002163_abnormal_gland_morphology1.97039994
31MP0002108_abnormal_muscle_morphology1.96900049
32MP0001293_anophthalmia1.91806218
33MP0005220_abnormal_exocrine_pancreas1.87430427
34MP0005332_abnormal_amino_acid1.86127699
35MP0001944_abnormal_pancreas_morphology1.78599839
36MP0001501_abnormal_sleep_pattern1.76515533
37MP0001666_abnormal_nutrient_absorption1.74737900
38MP0003195_calcinosis1.73927179
39MP0005367_renal/urinary_system_phenotyp1.73872686
40MP0000516_abnormal_urinary_system1.73872686
41MP0005377_hearing/vestibular/ear_phenot1.71160540
42MP0003878_abnormal_ear_physiology1.71160540
43MP0002102_abnormal_ear_morphology1.70867918
44MP0009780_abnormal_chondrocyte_physiolo1.69793631
45MP0002876_abnormal_thyroid_physiology1.68741480
46MP0002282_abnormal_trachea_morphology1.67926065
47MP0002078_abnormal_glucose_homeostasis1.66719111
48MP0005085_abnormal_gallbladder_physiolo1.63881195
49MP0000462_abnormal_digestive_system1.63813412
50MP0009840_abnormal_foam_cell1.60521224
51MP0001879_abnormal_lymphatic_vessel1.59948628
52MP0000534_abnormal_ureter_morphology1.56092590
53MP0009643_abnormal_urine_homeostasis1.55880622
54MP0002896_abnormal_bone_mineralization1.55423679
55MP0005448_abnormal_energy_balance1.53628773
56MP0003935_abnormal_craniofacial_develop1.51764109
57MP0003172_abnormal_lysosome_physiology1.49656878
58MP0000639_abnormal_adrenal_gland1.49402431
59MP0002177_abnormal_outer_ear1.45281507
60MP0003866_abnormal_defecation1.42802020
61MP0003385_abnormal_body_wall1.42534380
62MP0002638_abnormal_pupillary_reflex1.41582559
63MP0002116_abnormal_craniofacial_bone1.39316992
64MP0002098_abnormal_vibrissa_morphology1.34065693
65MP0003941_abnormal_skin_development1.31063931
66MP0005636_abnormal_mineral_homeostasis1.30205957
67MP0001756_abnormal_urination1.29391988
68MP0004134_abnormal_chest_morphology1.29200517
69MP0001502_abnormal_circadian_rhythm1.28141535
70MP0005535_abnormal_body_temperature1.27791662
71MP0005508_abnormal_skeleton_morphology1.27319479
72MP0000427_abnormal_hair_cycle1.26950826
73MP0003943_abnormal_hepatobiliary_system1.26218529
74MP0002118_abnormal_lipid_homeostasis1.24546801
75MP0002909_abnormal_adrenal_gland1.24247793
76MP0001664_abnormal_digestion1.23145258
77MP0004147_increased_porphyrin_level1.22402922
78MP0008775_abnormal_heart_ventricle1.22261304
79MP0002693_abnormal_pancreas_physiology1.21926971
80MP0003868_abnormal_feces_composition1.21370607
81MP0002295_abnormal_pulmonary_circulatio1.21043354
82MP0002277_abnormal_respiratory_mucosa1.19870598
83MP0002168_other_aberrant_phenotype1.18269772
84MP0008877_abnormal_DNA_methylation1.17651481
85MP0000163_abnormal_cartilage_morphology1.17632166
86MP0005253_abnormal_eye_physiology1.17429203
87MP0003879_abnormal_hair_cell1.17424693
88MP0005645_abnormal_hypothalamus_physiol1.15815261
89MP0003953_abnormal_hormone_level1.14539869
90MP0004264_abnormal_extraembryonic_tissu1.12941885
91MP0005670_abnormal_white_adipose1.12796531
92MP0000751_myopathy1.09805246
93MP0005174_abnormal_tail_pigmentation1.08877456
94MP0010352_gastrointestinal_tract_polyps1.08468235
95MP0000230_abnormal_systemic_arterial1.07546212
96MP0002009_preneoplasia1.06983264
97MP0001986_abnormal_taste_sensitivity1.06422078
98MP0003123_paternal_imprinting1.06103741
99MP0000647_abnormal_sebaceous_gland1.05810565
100MP0003283_abnormal_digestive_organ1.03656648
101MP0001346_abnormal_lacrimal_gland1.01501891
102MP0000569_abnormal_digit_pigmentation1.00486274
103MP0002254_reproductive_system_inflammat1.00278173
104MP0002115_abnormal_skeleton_extremities0.99520398
105MP0002109_abnormal_limb_morphology0.98419803
106MP0000049_abnormal_middle_ear0.98087655
107MP0000579_abnormal_nail_morphology0.97880803
108MP0005375_adipose_tissue_phenotype0.97535063
109MP0005409_darkened_coat_color0.97280085
110MP0009046_muscle_twitch0.97260710
111MP0003937_abnormal_limbs/digits/tail_de0.96747820
112MP0000762_abnormal_tongue_morphology0.94981491
113MP0002932_abnormal_joint_morphology0.93875127
114MP0003938_abnormal_ear_development0.93712798
115MP0002136_abnormal_kidney_physiology0.93366728
116MP0000613_abnormal_salivary_gland0.93251639
117MP0002971_abnormal_brown_adipose0.93062733
118MP0000372_irregular_coat_pigmentation0.93019662
119MP0004885_abnormal_endolymph0.91016728
120MP0003755_abnormal_palate_morphology0.90691961
121MP0003959_abnormal_lean_body0.89253789
122MP0000432_abnormal_head_morphology0.88875363
123MP0006072_abnormal_retinal_apoptosis0.88871119
124MP0008438_abnormal_cutaneous_collagen0.88801649
125MP0004510_myositis0.88348080
126MP0001270_distended_abdomen0.87700702
127MP0002089_abnormal_postnatal_growth/wei0.87663148
128MP0008961_abnormal_basal_metabolism0.86996939
129MP0010386_abnormal_urinary_bladder0.85153018
130MP0003045_fibrosis0.84942587
131MP0000631_abnormal_neuroendocrine_gland0.83405387
132MP0003119_abnormal_digestive_system0.82090377
133MP0001958_emphysema0.82080521
134MP0000678_abnormal_parathyroid_gland0.81494792
135MP0005551_abnormal_eye_electrophysiolog0.81310434
136MP0002092_abnormal_eye_morphology0.79537995
137MP0005595_abnormal_vascular_smooth0.79458348
138MP0002090_abnormal_vision0.79072801
139MP0003115_abnormal_respiratory_system0.78533620
140MP0003121_genomic_imprinting0.78392946
141MP0000371_diluted_coat_color0.78289749
142MP0002837_dystrophic_cardiac_calcinosis0.75774468
143MP0005058_abnormal_lysosome_morphology0.75614154
144MP0001177_atelectasis0.75562868
145MP0001765_abnormal_ion_homeostasis0.74781600
146MP0006054_spinal_hemorrhage0.74625344
147MP0010678_abnormal_skin_adnexa0.74503399
148MP0001340_abnormal_eyelid_morphology0.73948966
149MP0000538_abnormal_urinary_bladder0.73336650
150MP0004270_analgesia0.72210454
151MP0009053_abnormal_anal_canal0.72047472
152MP0002925_abnormal_cardiovascular_devel0.71256622
153MP0004085_abnormal_heartbeat0.71120414
154MP0003787_abnormal_imprinting0.71067131
155MP0000015_abnormal_ear_pigmentation0.69927836
156MP0002064_seizures0.69861994
157MP0009642_abnormal_blood_homeostasis0.68325150
158MP0003633_abnormal_nervous_system0.68118900
159MP0001188_hyperpigmentation0.67091364
160MP0002069_abnormal_eating/drinking_beha0.65469938
161MP0005408_hypopigmentation0.65379039
162MP0002734_abnormal_mechanical_nocicepti0.64872301
163MP0002229_neurodegeneration0.64535527
164* MP0002557_abnormal_social/conspecific_i0.64431677
165MP0002272_abnormal_nervous_system0.63653840

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the parietal bone (HP:0002696)6.72782239
2Midline defect of the nose (HP:0004122)6.49436348
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)5.05321304
4Short 4th metacarpal (HP:0010044)5.05321304
5Trigonocephaly (HP:0000243)4.96027337
6Ketoacidosis (HP:0001993)4.83054467
7Anteriorly placed anus (HP:0001545)4.50006384
8Neoplasm of the heart (HP:0100544)4.42423645
9Abnormal pancreas size (HP:0012094)4.17458926
10Nasolacrimal duct obstruction (HP:0000579)4.09727180
11Toxemia of pregnancy (HP:0100603)4.07907912
12Broad face (HP:0000283)4.07871066
13Insulin-resistant diabetes mellitus (HP:0000831)4.06784296
14Late onset (HP:0003584)4.01799638
15Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)3.99368273
16Broad metatarsal (HP:0001783)3.94232504
17Large for gestational age (HP:0001520)3.87326560
18Abnormality of glutamine family amino acid metabolism (HP:0010902)3.81512654
19Alacrima (HP:0000522)3.57687307
20Abnormality of the 4th metacarpal (HP:0010012)3.55546360
21Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.47604932
22Increased circulating renin level (HP:0000848)3.47591244
23Hyperphosphatemia (HP:0002905)3.40355976
24Abnormality of the diencephalon (HP:0010662)3.38691835
25Abnormality of the lacrimal duct (HP:0011481)3.35855449
26Abnormality of the nasal septum (HP:0000419)3.33302887
27Shallow orbits (HP:0000586)3.30690737
28Abnormality of the nasolacrimal system (HP:0000614)3.25446526
29Hypoplastic labia majora (HP:0000059)3.19362768
30Abnormality of the distal phalanx of the thumb (HP:0009617)3.15328055
31Abnormality of vitamin B metabolism (HP:0004340)3.14837527
32Abnormality of renin-angiotensin system (HP:0000847)3.12507185
33Aplasia involving bones of the upper limbs (HP:0009823)3.09803535
34Aplasia of the phalanges of the hand (HP:0009802)3.09803535
35Aplasia involving bones of the extremities (HP:0009825)3.09803535
36Decreased circulating renin level (HP:0003351)3.08368563
37Flat capital femoral epiphysis (HP:0003370)3.06688310
38Turricephaly (HP:0000262)3.05800880
39Exostoses (HP:0100777)3.02670543
40Proximal tubulopathy (HP:0000114)2.96950792
41Ketosis (HP:0001946)2.95787787
42Sparse lateral eyebrow (HP:0005338)2.89467044
43Short phalanx of the thumb (HP:0009660)2.86664198
44Hydroxyprolinuria (HP:0003080)2.86405594
45Abnormality of proline metabolism (HP:0010907)2.86405594
46Hypothermia (HP:0002045)2.85350188
47Malnutrition (HP:0004395)2.83852244
48Abnormality of the labia majora (HP:0012881)2.82521032
49Postural tremor (HP:0002174)2.76044195
50Vitreoretinal degeneration (HP:0000655)2.71773471
51Increased CSF protein (HP:0002922)2.71371165
52Ventricular fibrillation (HP:0001663)2.68334720
53Decreased lacrimation (HP:0000633)2.66939051
54Hyperinsulinemic hypoglycemia (HP:0000825)2.66726640
55Epileptiform EEG discharges (HP:0011182)2.65536845
56Synostosis involving the elbow (HP:0003938)2.65139503
57Humeroradial synostosis (HP:0003041)2.65139503
58Hyperglycemia (HP:0003074)2.65133022
59EEG with generalized epileptiform discharges (HP:0011198)2.63069408
60Broad toe (HP:0001837)2.59238330
61Depressed nasal tip (HP:0000437)2.57403637
62Aplasia cutis congenita (HP:0001057)2.57067875
63Abnormality of vitamin metabolism (HP:0100508)2.55308832
64Hyperactive renin-angiotensin system (HP:0000841)2.55189311
65Metabolic alkalosis (HP:0200114)2.54756555
66Narrow palate (HP:0000189)2.54720284
67Pigmentary retinal degeneration (HP:0001146)2.52889406
68Bronchomalacia (HP:0002780)2.52613109
69Partial duplication of the phalanx of hand (HP:0009999)2.50656429
70Down-sloping shoulders (HP:0200021)2.49014756
71Coronal craniosynostosis (HP:0004440)2.48911309
72Xanthomatosis (HP:0000991)2.47440882
73Concave nail (HP:0001598)2.45621074
74Hypsarrhythmia (HP:0002521)2.42442814
75Abnormality of calcium-phosphate metabolism (HP:0100530)2.42349067
76Neoplasm of the oral cavity (HP:0100649)2.42269929
77Abnormal number of incisors (HP:0011064)2.41149682
78Large earlobe (HP:0009748)2.40111559
79Abnormality of the vitamin B12 metabolism (HP:0004341)2.39567463
80Broad hallux (HP:0010055)2.39397385
81Partial duplication of thumb phalanx (HP:0009944)2.38026358
82Short metatarsal (HP:0010743)2.36622195
83Fetal akinesia sequence (HP:0001989)2.35662140
84Glomerulonephritis (HP:0000099)2.34725676
85Infantile muscular hypotonia (HP:0008947)2.33795713
86Menstrual irregularities (HP:0000858)2.32372164
87Pancreatic islet-cell hyperplasia (HP:0004510)2.31815012
88Hypoglycemic seizures (HP:0002173)2.31773155
89Abnormality of the incisor (HP:0000676)2.31648602
90Bilateral microphthalmos (HP:0007633)2.30869073
91Abnormality of urine glucose concentration (HP:0011016)2.30228315
92Glycosuria (HP:0003076)2.30228315
93Hypomagnesemia (HP:0002917)2.29869209
94Rectal fistula (HP:0100590)2.29690935
95Rectovaginal fistula (HP:0000143)2.29690935
96Intestinal fistula (HP:0100819)2.29251322
97Insulin resistance (HP:0000855)2.29249067
98Unilateral renal agenesis (HP:0000122)2.27912393
99Abnormality of magnesium homeostasis (HP:0004921)2.27692842
100Hypoplastic ischia (HP:0003175)2.26926029
101Supernumerary ribs (HP:0005815)2.26437231
102Prominent metopic ridge (HP:0005487)2.25407341
103Aplasia/Hypoplasia of metatarsal bones (HP:0001964)2.23490620
104Abnormality of the proximal phalanges of the hand (HP:0009834)2.23481754
105Congenital sensorineural hearing impairment (HP:0008527)2.22493050
106Abnormality of potassium homeostasis (HP:0011042)2.21044974
107Vaginal fistula (HP:0004320)2.20663551
108Action tremor (HP:0002345)2.19153508
109Vascular calcification (HP:0004934)2.18795218
110Stridor (HP:0010307)2.18389613
111Hyperparathyroidism (HP:0000843)2.18236088
112Protuberant abdomen (HP:0001538)2.17559337
113Hyperkalemia (HP:0002153)2.17232866
114Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.16161147
115Hypoglycemic coma (HP:0001325)2.13994050
116Testicular neoplasm (HP:0010788)2.12677952
117Hyperthyroidism (HP:0000836)2.12606897
118Abnormality of incisor morphology (HP:0011063)2.12430484
119Enlarged penis (HP:0000040)2.11810116
120Abnormality of the metopic suture (HP:0005556)2.11187156
121Hepatoblastoma (HP:0002884)2.09534370
122Bundle branch block (HP:0011710)2.08098760
123Bell-shaped thorax (HP:0001591)2.08037766
124Sex reversal (HP:0012245)2.05989171
125Abnormal sex determination (HP:0012244)2.05989171
126Agitation (HP:0000713)2.05162709
127Hypoplasia of the maxilla (HP:0000327)2.04942556
128Abnormality of the labia minora (HP:0012880)2.04839905
129Hematochezia (HP:0002573)2.04392385
130Anophthalmia (HP:0000528)2.03843966
131Mesomelia (HP:0003027)2.03721298
132Abnormality of the ischium (HP:0003174)2.03638308
133Metaphyseal dysplasia (HP:0100255)2.03610482
134Labial hypoplasia (HP:0000066)1.99559510
135Hypophosphatemia (HP:0002148)1.99167013
136Tongue fasciculations (HP:0001308)1.99149199
137Bone cyst (HP:0012062)1.98424443
138Polydipsia (HP:0001959)1.97791735
139Abnormal drinking behavior (HP:0030082)1.97791735
140Abnormality of the middle phalanges of the hand (HP:0009833)1.97427215
141Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.97285407
142Syncope (HP:0001279)1.97170386
143Anal stenosis (HP:0002025)1.97152709
144Mucopolysacchariduria (HP:0008155)1.96826049
145Urinary glycosaminoglycan excretion (HP:0003541)1.96826049
146Abdominal distention (HP:0003270)1.96488420
147Hypokalemia (HP:0002900)1.95336140
148Abnormal hand bone ossification (HP:0010660)1.94769042
149Macroorchidism (HP:0000053)1.93852002
150Ectopic anus (HP:0004397)1.93545763
151Double outlet right ventricle (HP:0001719)1.93476530
152Congenital malformation of the right heart (HP:0011723)1.93476530
153Microglossia (HP:0000171)1.93279861
154Growth hormone excess (HP:0000845)1.92514051
155Abnormality of polysaccharide metabolism (HP:0011012)1.92067619
156Abnormality of glycosaminoglycan metabolism (HP:0004371)1.92067619
157Abnormality of mucopolysaccharide metabolism (HP:0011020)1.92067619
158Type I diabetes mellitus (HP:0100651)1.92056052
159Deformed sella turcica (HP:0002681)1.91938714
160Supernumerary bones of the axial skeleton (HP:0009144)1.89599639
161Confusion (HP:0001289)1.89370388
162Symptomatic seizures (HP:0011145)1.87913050
163Recurrent corneal erosions (HP:0000495)1.86279433
164Milia (HP:0001056)1.84437936
165Villous atrophy (HP:0011473)1.83467523
166Abnormality of small intestinal villus morphology (HP:0011472)1.83467523
167Intestinal atresia (HP:0011100)1.83036482
168Abnormality of the renal cortex (HP:0011035)1.82430313
169Accelerated skeletal maturation (HP:0005616)1.82211015
170Buphthalmos (HP:0000557)1.81918116
171Abnormality of endocrine pancreas physiology (HP:0012093)1.80291868
172Abnormality of the pancreatic islet cells (HP:0006476)1.80291868
173Cardiovascular calcification (HP:0011915)1.80082623
174Increased number of teeth (HP:0011069)1.77860352
175Hypobetalipoproteinemia (HP:0003563)1.77482982
176Abnormal biliary tract morphology (HP:0012440)1.76714735
177Chorioretinal atrophy (HP:0000533)1.74845518
178Preaxial foot polydactyly (HP:0001841)1.74076677
179Abnormal albumin level (HP:0012116)1.73114995
180Hypoalbuminemia (HP:0003073)1.73114995
181Broad thumb (HP:0011304)1.72871944
182Aplasia/hypoplasia of the uterus (HP:0008684)1.72084112
183Hyperlipoproteinemia (HP:0010980)1.71373253
184Diminished movement (HP:0002374)1.70112423
185Disproportionate short-trunk short stature (HP:0003521)1.67547178
186Popliteal pterygium (HP:0009756)1.67239851

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK36.86924877
2MAPK156.08939574
3FGFR23.84474794
4ACVR1B3.64692787
5WNK43.55036502
6TIE13.21474228
7FRK3.10398034
8LATS12.93678278
9GRK12.86073975
10PHKG12.61588907
11PHKG22.61588907
12INSRR2.46337800
13DAPK22.40465346
14MAP3K92.15238130
15MST42.05502112
16NLK2.03627535
17MAP2K62.02426725
18PDGFRA1.99184315
19WNK11.88189669
20KDR1.84887791
21TRPM71.81706348
22DDR21.79305424
23RIPK11.77632866
24FER1.64447932
25NUAK11.63978491
26EPHA31.63333694
27TGFBR21.60204445
28PIK3CG1.60065009
29CASK1.59968994
30MKNK21.59641835
31PRKD31.52223178
32CAMK1G1.51551165
33AKT31.45275556
34ADRBK21.42374791
35OXSR11.41966512
36MAP3K21.40867382
37LMTK21.38704539
38STK241.38507850
39HIPK21.35364235
40STK391.34652053
41FGFR11.34451123
42SIK11.33088696
43STK161.25071901
44YES11.22114697
45CAMK1D1.19494529
46PINK11.14761801
47EPHB21.14052460
48UHMK11.13590475
49PTK61.13399333
50PTK21.12305716
51PDGFRB0.99016760
52CDC42BPA0.90398701
53TAOK30.88517381
54CAMKK20.88208372
55DMPK0.87959305
56BRSK20.86484221
57ERN10.86381184
58MUSK0.83866356
59BMX0.82281084
60PRKCH0.82009322
61MAP3K10.77778280
62MAP2K20.77080122
63PRKCG0.73952806
64BRD40.71767393
65FGFR40.71061211
66MARK20.70886453
67ERBB20.69690414
68EPHA20.69249351
69PIK3CA0.68658080
70PAK30.68609247
71EPHB10.67978371
72STK38L0.67074997
73PRKD20.65305876
74PRKCE0.65245708
75MTOR0.64891426
76MOS0.62756589
77MAP3K120.61946028
78PRKD10.61526326
79CSNK1A1L0.61318960
80MAPK70.58603218
81CSK0.58327482
82EIF2AK30.57388799
83RET0.56939620
84NTRK10.56938591
85CAMK40.55887028
86SGK20.54583538
87SGK30.53930074
88GSK3A0.53417589
89PDPK10.52964298
90TGFBR10.52037715
91PDK10.51960391
92SGK4940.51312417
93SGK2230.51312417
94MST1R0.50986606
95DYRK1B0.49702369
96TAOK10.48898918
97IRAK20.48309212
98PRKCA0.48181634
99PRKCZ0.45892135
100IGF1R0.45513632
101MAP3K70.45005932
102PRKACA0.44729686
103IRAK10.44174270
104MAP3K30.43971726
105CAMK2D0.40562846
106KSR20.39461380
107PRKACG0.39058535
108CHUK0.36792268
109PNCK0.36369260
110CAMK2A0.36116617
111MAP2K10.36091636
112NTRK30.34301294
113PRKAA20.34278186
114ERBB40.34251600
115BMPR1B0.33157466
116STK110.33107991
117TNIK0.32059427
118CSNK1A10.31360118
119MET0.30940417
120SGK10.28937291
121CAMK2B0.28595516
122PRKG10.28333851
123STK30.27829302
124CSNK1G30.27708635
125PRKG20.27407626
126STK380.26380228
127CSNK1G20.26334110
128CAMK10.26057977
129PTK2B0.25531797
130ADRBK10.25113173
131JAK10.25109476
132JAK20.23332087
133TEC0.23331478
134ROCK10.22961627
135INSR0.22846645
136FGFR30.22564028
137PRKAA10.20916214
138NEK90.20589948
139PASK0.20122699
140SRC0.19916639
141MAPK10.19387187
142TRIB30.17746221
143PRKCI0.17667008
144CSNK1G10.17383224

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.22665657
2Hedgehog signaling pathway_Homo sapiens_hsa043403.36382476
3Basal cell carcinoma_Homo sapiens_hsa052173.29719924
4Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.74378733
5Insulin secretion_Homo sapiens_hsa049112.54019948
6Type II diabetes mellitus_Homo sapiens_hsa049301.89883744
7Protein digestion and absorption_Homo sapiens_hsa049741.83387283
8Wnt signaling pathway_Homo sapiens_hsa043101.82052078
9Cyanoamino acid metabolism_Homo sapiens_hsa004601.74043349
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.71331492
11Renin secretion_Homo sapiens_hsa049241.68329188
12Cocaine addiction_Homo sapiens_hsa050301.66133853
13Adherens junction_Homo sapiens_hsa045201.62899318
14Butanoate metabolism_Homo sapiens_hsa006501.59779767
15Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.52044191
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.45080099
17TGF-beta signaling pathway_Homo sapiens_hsa043501.44736041
18ECM-receptor interaction_Homo sapiens_hsa045121.43535448
19cAMP signaling pathway_Homo sapiens_hsa040241.43158788
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.42059006
21Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.40763832
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.38578303
23Sphingolipid metabolism_Homo sapiens_hsa006001.38544686
24Amphetamine addiction_Homo sapiens_hsa050311.35341314
25Melanogenesis_Homo sapiens_hsa049161.34579631
26Sulfur metabolism_Homo sapiens_hsa009201.33643382
27Melanoma_Homo sapiens_hsa052181.29640694
28Tryptophan metabolism_Homo sapiens_hsa003801.29611904
29Linoleic acid metabolism_Homo sapiens_hsa005911.27738807
30Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.26679198
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.25777004
32Retinol metabolism_Homo sapiens_hsa008301.25670596
33Prostate cancer_Homo sapiens_hsa052151.25348744
34Protein export_Homo sapiens_hsa030601.22494658
35Circadian rhythm_Homo sapiens_hsa047101.22342252
36Pathways in cancer_Homo sapiens_hsa052001.20715396
37Focal adhesion_Homo sapiens_hsa045101.19044039
38Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.18049408
39Starch and sucrose metabolism_Homo sapiens_hsa005001.16613241
40Fructose and mannose metabolism_Homo sapiens_hsa000511.15569117
41PPAR signaling pathway_Homo sapiens_hsa033201.15507673
42Vascular smooth muscle contraction_Homo sapiens_hsa042701.15140185
43Circadian entrainment_Homo sapiens_hsa047131.14352268
44Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.13602694
45Caffeine metabolism_Homo sapiens_hsa002321.13599921
46Type I diabetes mellitus_Homo sapiens_hsa049401.13148420
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.13030464
48Hippo signaling pathway_Homo sapiens_hsa043901.12534663
49Proteoglycans in cancer_Homo sapiens_hsa052051.12423155
50Ether lipid metabolism_Homo sapiens_hsa005651.11841609
51Thyroid hormone synthesis_Homo sapiens_hsa049181.11412175
52Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.11129449
53Dilated cardiomyopathy_Homo sapiens_hsa054141.10124913
54Arginine biosynthesis_Homo sapiens_hsa002201.09937998
55Glucagon signaling pathway_Homo sapiens_hsa049221.09887855
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09324097
57Other glycan degradation_Homo sapiens_hsa005111.09119026
58alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.08101166
59Fatty acid degradation_Homo sapiens_hsa000711.05828531
60Amoebiasis_Homo sapiens_hsa051461.05820485
61Estrogen signaling pathway_Homo sapiens_hsa049151.05616531
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.04044338
63Thyroid hormone signaling pathway_Homo sapiens_hsa049191.02606140
64Vibrio cholerae infection_Homo sapiens_hsa051101.01151028
65cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00703621
66Gastric acid secretion_Homo sapiens_hsa049711.00486266
67Rap1 signaling pathway_Homo sapiens_hsa040150.99057620
68Arachidonic acid metabolism_Homo sapiens_hsa005900.98738123
69Histidine metabolism_Homo sapiens_hsa003400.97215995
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96092814
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.95419087
72Pancreatic secretion_Homo sapiens_hsa049720.94862893
73Fat digestion and absorption_Homo sapiens_hsa049750.94717714
74Vitamin digestion and absorption_Homo sapiens_hsa049770.93983532
75Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.93523398
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.93242258
77Gap junction_Homo sapiens_hsa045400.91914593
78Axon guidance_Homo sapiens_hsa043600.91838251
79Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.91347013
80Regulation of autophagy_Homo sapiens_hsa041400.89322650
81Nitrogen metabolism_Homo sapiens_hsa009100.89092541
82Cholinergic synapse_Homo sapiens_hsa047250.88508481
83Dopaminergic synapse_Homo sapiens_hsa047280.87720147
84GABAergic synapse_Homo sapiens_hsa047270.87313596
85Prion diseases_Homo sapiens_hsa050200.86229046
86Mineral absorption_Homo sapiens_hsa049780.85885098
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84673746
88Renin-angiotensin system_Homo sapiens_hsa046140.84405676
89PI3K-Akt signaling pathway_Homo sapiens_hsa041510.83736855
90Fatty acid metabolism_Homo sapiens_hsa012120.83100757
91Collecting duct acid secretion_Homo sapiens_hsa049660.82845980
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82047360
93Bile secretion_Homo sapiens_hsa049760.80712920
94Chemical carcinogenesis_Homo sapiens_hsa052040.80654438
95Colorectal cancer_Homo sapiens_hsa052100.79965045
96Thyroid cancer_Homo sapiens_hsa052160.78477734
97Peroxisome_Homo sapiens_hsa041460.78279285
98Galactose metabolism_Homo sapiens_hsa000520.77770067
99Ras signaling pathway_Homo sapiens_hsa040140.77519833
100Fatty acid elongation_Homo sapiens_hsa000620.77385458
101Long-term depression_Homo sapiens_hsa047300.77329183
102SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76411673
103Ovarian steroidogenesis_Homo sapiens_hsa049130.74509461
104Tight junction_Homo sapiens_hsa045300.73002815
105Dorso-ventral axis formation_Homo sapiens_hsa043200.72445185
106Phototransduction_Homo sapiens_hsa047440.72204618
107Renal cell carcinoma_Homo sapiens_hsa052110.71338558
108Long-term potentiation_Homo sapiens_hsa047200.71076277
109Steroid hormone biosynthesis_Homo sapiens_hsa001400.70596841
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68712485
111Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.67810292
112MicroRNAs in cancer_Homo sapiens_hsa052060.67055527
113Folate biosynthesis_Homo sapiens_hsa007900.66749746
114Endometrial cancer_Homo sapiens_hsa052130.65895660
115Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.65253314
116ABC transporters_Homo sapiens_hsa020100.64796538
117Glycosaminoglycan degradation_Homo sapiens_hsa005310.64663888
118Lysine degradation_Homo sapiens_hsa003100.64564809
119Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64108491
120Synaptic vesicle cycle_Homo sapiens_hsa047210.63924493
121Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63202838
122Insulin resistance_Homo sapiens_hsa049310.62380318
123GnRH signaling pathway_Homo sapiens_hsa049120.61454418
124Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60814507
125Oxytocin signaling pathway_Homo sapiens_hsa049210.60692707
126Serotonergic synapse_Homo sapiens_hsa047260.59565914
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59312241
128Small cell lung cancer_Homo sapiens_hsa052220.59102039
129MAPK signaling pathway_Homo sapiens_hsa040100.57317573
130Insulin signaling pathway_Homo sapiens_hsa049100.56301082
131Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55033523
132Selenocompound metabolism_Homo sapiens_hsa004500.54592149
133Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54004012
134Morphine addiction_Homo sapiens_hsa050320.53177988
135Salivary secretion_Homo sapiens_hsa049700.52175398
136AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50976043
137Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50679413
138Glioma_Homo sapiens_hsa052140.50549726
139ErbB signaling pathway_Homo sapiens_hsa040120.50200240
140Adipocytokine signaling pathway_Homo sapiens_hsa049200.49833315
141Chronic myeloid leukemia_Homo sapiens_hsa052200.49497723
142beta-Alanine metabolism_Homo sapiens_hsa004100.49395659
143Glutamatergic synapse_Homo sapiens_hsa047240.47866108
144Glycerolipid metabolism_Homo sapiens_hsa005610.45779305
145AMPK signaling pathway_Homo sapiens_hsa041520.45678147
146Vitamin B6 metabolism_Homo sapiens_hsa007500.44917895
147Propanoate metabolism_Homo sapiens_hsa006400.44407308
148Glycerophospholipid metabolism_Homo sapiens_hsa005640.42070742
149Glutathione metabolism_Homo sapiens_hsa004800.41686702
150Inositol phosphate metabolism_Homo sapiens_hsa005620.41103192
151Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38864233
1522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.38460277
153Drug metabolism - other enzymes_Homo sapiens_hsa009830.37293916
154Lysosome_Homo sapiens_hsa041420.35287864
155Fatty acid biosynthesis_Homo sapiens_hsa000610.33963043

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