ECHDC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.76680966
2L-phenylalanine catabolic process (GO:0006559)6.76680966
3L-phenylalanine metabolic process (GO:0006558)6.36078972
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.36078972
5alpha-linolenic acid metabolic process (GO:0036109)5.74661043
6aromatic amino acid family catabolic process (GO:0009074)5.61273960
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.07089647
8bile acid biosynthetic process (GO:0006699)5.06971524
9cysteine metabolic process (GO:0006534)4.93732739
10proteasome assembly (GO:0043248)4.83576229
11glyoxylate metabolic process (GO:0046487)4.79145077
12sulfur amino acid catabolic process (GO:0000098)4.74040724
13mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.65558362
14regulation of triglyceride catabolic process (GO:0010896)4.62651455
15fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.62229637
16indole-containing compound catabolic process (GO:0042436)4.61309690
17indolalkylamine catabolic process (GO:0046218)4.61309690
18tryptophan catabolic process (GO:0006569)4.61309690
19fatty acid homeostasis (GO:0055089)4.60560001
20acetyl-CoA metabolic process (GO:0006084)4.56697057
21fatty-acyl-CoA biosynthetic process (GO:0046949)4.56593782
22complement activation, alternative pathway (GO:0006957)4.47123830
23kynurenine metabolic process (GO:0070189)4.45314646
24urea cycle (GO:0000050)4.41583771
25urea metabolic process (GO:0019627)4.41583771
26thioester biosynthetic process (GO:0035384)4.39885346
27acyl-CoA biosynthetic process (GO:0071616)4.39885346
28long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.38797257
29tryptophan metabolic process (GO:0006568)4.37295268
30bile acid metabolic process (GO:0008206)4.29651214
31short-chain fatty acid metabolic process (GO:0046459)4.25064487
32tyrosine metabolic process (GO:0006570)4.24718149
33ethanol oxidation (GO:0006069)4.24130861
34fatty acid beta-oxidation (GO:0006635)4.21553494
35valine metabolic process (GO:0006573)4.21534545
36fatty acid elongation (GO:0030497)4.21152229
37protein neddylation (GO:0045116)4.19366956
38cellular ketone body metabolic process (GO:0046950)4.17051881
39fatty-acyl-CoA metabolic process (GO:0035337)4.16270721
40plasma lipoprotein particle clearance (GO:0034381)4.14224179
41lysine catabolic process (GO:0006554)4.12553367
42lysine metabolic process (GO:0006553)4.12553367
43nitrogen cycle metabolic process (GO:0071941)4.11776167
44triglyceride homeostasis (GO:0070328)4.11408737
45acylglycerol homeostasis (GO:0055090)4.11408737
46high-density lipoprotein particle remodeling (GO:0034375)4.10850510
47energy coupled proton transport, down electrochemical gradient (GO:0015985)4.10549030
48ATP synthesis coupled proton transport (GO:0015986)4.10549030
49peptidyl-glutamic acid carboxylation (GO:0017187)4.09898466
50protein carboxylation (GO:0018214)4.09898466
51coenzyme catabolic process (GO:0009109)4.09854739
52establishment of protein localization to mitochondrial membrane (GO:0090151)4.09431841
53aromatic amino acid family metabolic process (GO:0009072)4.06787694
54biotin metabolic process (GO:0006768)4.05624460
55fatty acid catabolic process (GO:0009062)4.04918939
56fatty acid oxidation (GO:0019395)4.02561409
57negative regulation of fibrinolysis (GO:0051918)4.02550255
58regulation of protein activation cascade (GO:2000257)4.00801188
59very long-chain fatty acid metabolic process (GO:0000038)3.98224510
60branched-chain amino acid catabolic process (GO:0009083)3.95797105
61lipid oxidation (GO:0034440)3.94649737
62alpha-amino acid catabolic process (GO:1901606)3.94244837
63amino-acid betaine metabolic process (GO:0006577)3.94152021
64regulation of fibrinolysis (GO:0051917)3.94055592
65regulation of sequestering of triglyceride (GO:0010889)3.93583904
66acyl-CoA metabolic process (GO:0006637)3.91703375
67thioester metabolic process (GO:0035383)3.91703375
68monocarboxylic acid catabolic process (GO:0072329)3.82869420
69long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.80979190
70triglyceride catabolic process (GO:0019433)3.80937154
71serine family amino acid catabolic process (GO:0009071)3.80146194
72regulation of complement activation (GO:0030449)3.77347663
73cellular amino acid catabolic process (GO:0009063)3.76750199
74DNA double-strand break processing (GO:0000729)3.75126552
75cullin deneddylation (GO:0010388)3.70291849
76homocysteine metabolic process (GO:0050667)3.69811608
77ketone body metabolic process (GO:1902224)3.69328926
78neutral lipid catabolic process (GO:0046461)3.69066516
79acylglycerol catabolic process (GO:0046464)3.69066516
80branched-chain amino acid metabolic process (GO:0009081)3.68122780
81protein-lipid complex remodeling (GO:0034368)3.66342345
82macromolecular complex remodeling (GO:0034367)3.66342345
83plasma lipoprotein particle remodeling (GO:0034369)3.66342345
84carboxylic acid catabolic process (GO:0046395)3.61921240
85organic acid catabolic process (GO:0016054)3.61921240
86regulation of cholesterol esterification (GO:0010872)3.61871039
87cellular glucuronidation (GO:0052695)3.61558588
88positive regulation of lipid catabolic process (GO:0050996)3.61153257
89oxidative phosphorylation (GO:0006119)3.57609417
90positive regulation of fatty acid beta-oxidation (GO:0032000)3.57453661
91reverse cholesterol transport (GO:0043691)3.57218163
92negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.55897247
93negative regulation of lipase activity (GO:0060192)3.54488013
94chaperone-mediated protein transport (GO:0072321)3.52172685
95fatty acid transmembrane transport (GO:1902001)3.50260560
96mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.50123169
97respiratory electron transport chain (GO:0022904)3.49540016
98low-density lipoprotein particle clearance (GO:0034383)3.49473999
99regulation of cholesterol metabolic process (GO:0090181)3.48822730
100cofactor catabolic process (GO:0051187)3.48589717
101aspartate family amino acid catabolic process (GO:0009068)3.46608590
102glutamate metabolic process (GO:0006536)3.43465695
103serine family amino acid metabolic process (GO:0009069)3.41735685
104triglyceride metabolic process (GO:0006641)3.41593945
105electron transport chain (GO:0022900)3.38644456
106protein deneddylation (GO:0000338)3.38488757
107CENP-A containing nucleosome assembly (GO:0034080)3.37870231
108chromatin remodeling at centromere (GO:0031055)3.37769049
109triglyceride biosynthetic process (GO:0019432)3.36600813
110ethanol metabolic process (GO:0006067)3.34937216
111bile acid and bile salt transport (GO:0015721)3.34718147
112acylglycerol biosynthetic process (GO:0046463)3.33635621
113neutral lipid biosynthetic process (GO:0046460)3.33635621
114phospholipid efflux (GO:0033700)3.33253383
115aldehyde catabolic process (GO:0046185)3.32239628
116regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.31758177
117amine catabolic process (GO:0009310)3.31028694
118cellular biogenic amine catabolic process (GO:0042402)3.31028694
119serine family amino acid biosynthetic process (GO:0009070)3.30786670
120lipid particle organization (GO:0034389)3.29851942
121positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.24990684
122tricarboxylic acid cycle (GO:0006099)3.24654309
123ribosome assembly (GO:0042255)3.22122011
124regulation of cellular amino acid metabolic process (GO:0006521)3.21225059
125brown fat cell differentiation (GO:0050873)3.21099787
126nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.19140497
127negative regulation of ligase activity (GO:0051352)3.18492917
128negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.18492917
129glycerol metabolic process (GO:0006071)3.16787767
130cholesterol biosynthetic process (GO:0006695)3.16260235
131establishment of integrated proviral latency (GO:0075713)3.15955000
132ether lipid metabolic process (GO:0046485)3.11874302
133exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.07855187
134response to nitrosative stress (GO:0051409)3.07187701
135sterol biosynthetic process (GO:0016126)3.06169639
136histone mRNA metabolic process (GO:0008334)3.03407371
137organelle disassembly (GO:1903008)3.03199717
138primary alcohol metabolic process (GO:0034308)3.03137036
139respiratory chain complex IV assembly (GO:0008535)3.03081217
140anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.00991073
141formation of translation preinitiation complex (GO:0001731)3.00292906
142DNA catabolic process, exonucleolytic (GO:0000738)2.98199762
143phospholipid homeostasis (GO:0055091)2.97571556
144purine nucleobase biosynthetic process (GO:0009113)2.97563287
145ribonucleoprotein complex disassembly (GO:0032988)2.96295540
146regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.96292557
147L-methionine salvage (GO:0071267)2.93724975
148L-methionine biosynthetic process (GO:0071265)2.93724975
149amino acid salvage (GO:0043102)2.93724975
150mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.92575868
151mitochondrial respiratory chain complex I assembly (GO:0032981)2.92575868
152NADH dehydrogenase complex assembly (GO:0010257)2.92575868
153NADH metabolic process (GO:0006734)2.92458982
154response to phenylpropanoid (GO:0080184)2.91898617
155polyketide metabolic process (GO:0030638)2.90338315
156doxorubicin metabolic process (GO:0044598)2.90338315
157daunorubicin metabolic process (GO:0044597)2.90338315
158DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.89785349
159signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.88779683
160signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.88779683
161signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.88779683
162glycerol ether metabolic process (GO:0006662)2.86728020
163termination of RNA polymerase III transcription (GO:0006386)2.86530474
164transcription elongation from RNA polymerase III promoter (GO:0006385)2.86530474
165signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.83633909
166intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.83633909
167protein complex biogenesis (GO:0070271)2.82749006
168alditol metabolic process (GO:0019400)2.80596759
169L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.80464654
170DNA damage response, detection of DNA damage (GO:0042769)2.77703656
171signal transduction involved in cell cycle checkpoint (GO:0072395)2.76957887
172protein targeting to mitochondrion (GO:0006626)2.76804369
173rRNA modification (GO:0000154)2.76717497
174signal transduction involved in DNA integrity checkpoint (GO:0072401)2.73390506
175signal transduction involved in DNA damage checkpoint (GO:0072422)2.73390506
176positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.72987244

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.72372872
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.65477815
3* RXR_22158963_ChIP-Seq_LIVER_Mouse6.86730933
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.74841210
5* EGR1_23403033_ChIP-Seq_LIVER_Mouse5.57909889
6LXR_22158963_ChIP-Seq_LIVER_Mouse5.52238237
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.70853344
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.34479297
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.08981594
10* GABP_17652178_ChIP-ChIP_JURKAT_Human4.05933404
11EST1_17652178_ChIP-ChIP_JURKAT_Human3.38390829
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.26831874
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.24563678
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.20175443
15ELK1_19687146_ChIP-ChIP_HELA_Human3.11590426
16* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.69456252
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.69240140
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.54680803
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.45823908
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.44495683
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.40887460
22E2F7_22180533_ChIP-Seq_HELA_Human2.37667310
23* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.34170839
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.34014114
25VDR_23849224_ChIP-Seq_CD4+_Human2.27280141
26SALL1_21062744_ChIP-ChIP_HESCs_Human2.26914487
27* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.12137551
28CLOCK_20551151_ChIP-Seq_293T_Human2.11921990
29* ETS1_20019798_ChIP-Seq_JURKAT_Human2.08290521
30FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.05051267
31FUS_26573619_Chip-Seq_HEK293_Human1.99741314
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.94100508
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.90925771
34SRF_21415370_ChIP-Seq_HL-1_Mouse1.89274506
35HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.83600908
36PADI4_21655091_ChIP-ChIP_MCF-7_Human1.83406415
37DCP1A_22483619_ChIP-Seq_HELA_Human1.82949046
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.79350367
39* EWS_26573619_Chip-Seq_HEK293_Human1.78676714
40* FOXP3_21729870_ChIP-Seq_TREG_Human1.78047995
41SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.77034020
42E2F1_18555785_ChIP-Seq_MESCs_Mouse1.73490293
43TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.72840575
44HTT_18923047_ChIP-ChIP_STHdh_Human1.68650676
45MYC_19030024_ChIP-ChIP_MESCs_Mouse1.67008842
46MYC_18358816_ChIP-ChIP_MESCs_Mouse1.64526603
47STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.62306595
48VDR_22108803_ChIP-Seq_LS180_Human1.61735746
49NELFA_20434984_ChIP-Seq_ESCs_Mouse1.60992844
50* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.57259239
51IGF1R_20145208_ChIP-Seq_DFB_Human1.56998828
52EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.53300213
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53041872
54AR_21909140_ChIP-Seq_LNCAP_Human1.51856160
55PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.47676419
56RBPJ_22232070_ChIP-Seq_NCS_Mouse1.46814656
57TAF15_26573619_Chip-Seq_HEK293_Human1.46315654
58KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.42601599
59E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.38601504
60GATA1_22025678_ChIP-Seq_K562_Human1.37455281
61TTF2_22483619_ChIP-Seq_HELA_Human1.36726425
62* FOXA2_19822575_ChIP-Seq_HepG2_Human1.36250340
63FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.36118562
64MYC_18940864_ChIP-ChIP_HL60_Human1.35649621
65* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.29363652
66MYC_19079543_ChIP-ChIP_MESCs_Mouse1.27820184
67NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.27615869
68NRF2_20460467_ChIP-Seq_MEFs_Mouse1.27615869
69GABP_19822575_ChIP-Seq_HepG2_Human1.26665985
70HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.21751134
71* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20729518
72* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.19071264
73ELK1_22589737_ChIP-Seq_MCF10A_Human1.18984827
74PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17918387
75CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.13791562
76* EZH2_27294783_Chip-Seq_NPCs_Mouse1.13470620
77ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.13338323
78YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11959854
79EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11189864
80PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10241055
81SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09465949
82* HNF4A_19822575_ChIP-Seq_HepG2_Human1.08420104
83ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.06813451
84AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04438043
85POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03989223
86STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.03538577
87PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.03279970
88SOX2_27498859_Chip-Seq_STOMACH_Mouse1.02695262
89NFE2_27457419_Chip-Seq_LIVER_Mouse1.01979088
90TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.01442186
91E2F1_21310950_ChIP-Seq_MCF-7_Human1.01407911
92ZNF274_21170338_ChIP-Seq_K562_Hela1.01009941
93ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.00476694
94GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98713660
95SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98296538
96NANOG_16153702_ChIP-ChIP_HESCs_Human0.98208759
97PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.97689567
98PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.97488378
99* SALL4_22934838_ChIP-ChIP_CD34+_Human0.96869864
100PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.96612769
101SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96295594
102FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.95785452
103POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.95607223
104SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.95044250
105CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93816449
106SOX17_20123909_ChIP-Seq_XEN_Mouse0.93688093
107* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92581765
108BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92527145
109ZFX_18555785_ChIP-Seq_MESCs_Mouse0.91456784
110MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91212031
111ESR1_20079471_ChIP-ChIP_T-47D_Human0.90064028
112THAP11_20581084_ChIP-Seq_MESCs_Mouse0.89458607
113MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.88724530
114AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.88680037
115POU5F1_16153702_ChIP-ChIP_HESCs_Human0.87086075
116* GATA4_25053715_ChIP-Seq_YYC3_Human0.86843304
117CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.86125431
118RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.83194219
119PIAS1_25552417_ChIP-Seq_VCAP_Human0.82958033
120PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.79800853
121* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.78661265
122FOXA1_25552417_ChIP-Seq_VCAP_Human0.77665290
123CBP_21632823_ChIP-Seq_H3396_Human0.76327773
124SOX2_20726797_ChIP-Seq_SW620_Human0.75362658
125RXRA_24833708_ChIP-Seq_LIVER_Mouse0.74996650
126Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.74017875
127CDX2_19796622_ChIP-Seq_MESCs_Mouse0.73265351
128TRIM28_21343339_ChIP-Seq_HEK293_Human0.70930218
129PPAR_26484153_Chip-Seq_NCI-H1993_Human0.70920151
130* FOXO3_23340844_ChIP-Seq_DLD1_Human0.70279041
131BCAT_22108803_ChIP-Seq_LS180_Human0.70179047
132ESR2_21235772_ChIP-Seq_MCF-7_Human0.69846800
133ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.69658168
134AR_20517297_ChIP-Seq_VCAP_Human0.68270023
135ERG_20517297_ChIP-Seq_VCAP_Human0.68202617
136AR_21572438_ChIP-Seq_LNCaP_Human0.66970776
137AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.66689788
138ER_23166858_ChIP-Seq_MCF-7_Human0.66563681
139CEBPB_22108803_ChIP-Seq_LS180_Human0.66489306
140RARG_19884340_ChIP-ChIP_MEFs_Mouse0.66085069
141SALL4_18804426_ChIP-ChIP_XEN_Mouse0.63713451
142ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.63082697
143IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.62193648
144CBP_20019798_ChIP-Seq_JUKART_Human0.62193648
145* SOX2_19829295_ChIP-Seq_ESCs_Human0.60477155
146* NANOG_19829295_ChIP-Seq_ESCs_Human0.60477155
147RAD21_21589869_ChIP-Seq_MESCs_Mouse0.59256993
148ZNF263_19887448_ChIP-Seq_K562_Human0.58825779
149P53_21459846_ChIP-Seq_SAOS-2_Human0.58427187
150NCOR_22424771_ChIP-Seq_293T_Human0.56689863
151CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.56319782
152OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.55942420
153POU3F2_20337985_ChIP-ChIP_501MEL_Human0.55752448
154PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.55428190
155KAP1_22055183_ChIP-Seq_ESCs_Mouse0.53596008
156CDX2_22108803_ChIP-Seq_LS180_Human0.52248636
157GBX2_23144817_ChIP-Seq_PC3_Human0.51555601
158EGR1_19032775_ChIP-ChIP_M12_Human0.50818432
159MYC_19915707_ChIP-ChIP_AK7_Human0.50258996
160ESET_19884257_ChIP-Seq_ESCs_Mouse0.50107695
161* CRX_20693478_ChIP-Seq_RETINA_Mouse0.50005448
162TP63_23658742_ChIP-Seq_EP156T_Human0.49895016
163* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.49861473
164* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.49387504
165NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.49281765
166SMAD4_21741376_ChIP-Seq_EPCs_Human0.49150447
167STAT1_17558387_ChIP-Seq_HELA_Human0.49133603
168WT1_19549856_ChIP-ChIP_CCG9911_Human0.49100444
169IRF1_19129219_ChIP-ChIP_H3396_Human0.48767821
170P300_19829295_ChIP-Seq_ESCs_Human0.48477682
171* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.48438803
172EP300_21415370_ChIP-Seq_HL-1_Mouse0.48075074
173* FOXA1_21572438_ChIP-Seq_LNCaP_Human0.47121075
174UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.47039744

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.41724951
2MP0005360_urolithiasis6.48632961
3MP0005365_abnormal_bile_salt5.37852713
4MP0005085_abnormal_gallbladder_physiolo5.31818317
5MP0008875_abnormal_xenobiotic_pharmacok4.27649357
6MP0003806_abnormal_nucleotide_metabolis4.14974107
7MP0010329_abnormal_lipoprotein_level3.55376971
8MP0003252_abnormal_bile_duct2.99846544
9MP0008058_abnormal_DNA_repair2.90289006
10MP0003195_calcinosis2.67741320
11MP0005332_abnormal_amino_acid2.67556093
12MP0005083_abnormal_biliary_tract2.62129952
13MP0002118_abnormal_lipid_homeostasis2.47379717
14MP0005670_abnormal_white_adipose2.43992672
15MP0009840_abnormal_foam_cell2.42343818
16MP0001666_abnormal_nutrient_absorption2.33230419
17MP0010094_abnormal_chromosome_stability2.21042422
18MP0003191_abnormal_cellular_cholesterol2.12639256
19MP0004957_abnormal_blastocyst_morpholog2.11100827
20MP0002102_abnormal_ear_morphology2.10417888
21MP0004130_abnormal_muscle_cell2.04548784
22MP0000372_irregular_coat_pigmentation2.03978881
23MP0000609_abnormal_liver_physiology2.02672492
24MP0008057_abnormal_DNA_replication1.98961033
25MP0005666_abnormal_adipose_tissue1.86089428
26MP0001529_abnormal_vocalization1.82314013
27MP0005584_abnormal_enzyme/coenzyme_acti1.81741427
28MP0004019_abnormal_vitamin_homeostasis1.73466302
29MP0008007_abnormal_cellular_replicative1.73168083
30MP0003186_abnormal_redox_activity1.68318554
31MP0004185_abnormal_adipocyte_glucose1.67090202
32MP0001764_abnormal_homeostasis1.66346124
33MP0005319_abnormal_enzyme/_coenzyme1.61441662
34MP0002971_abnormal_brown_adipose1.60428123
35MP0002876_abnormal_thyroid_physiology1.56996358
36MP0003011_delayed_dark_adaptation1.56323795
37MP0003868_abnormal_feces_composition1.53723187
38MP0009697_abnormal_copulation1.49726653
39MP0003693_abnormal_embryo_hatching1.47347747
40MP0003567_abnormal_fetal_cardiomyocyte1.46614198
41MP0006036_abnormal_mitochondrial_physio1.43283523
42MP0006054_spinal_hemorrhage1.39950050
43MP0003690_abnormal_glial_cell1.37699656
44MP0003656_abnormal_erythrocyte_physiolo1.35954928
45MP0009672_abnormal_birth_weight1.31159435
46MP0001661_extended_life_span1.30448843
47MP0004147_increased_porphyrin_level1.29508587
48MP0009643_abnormal_urine_homeostasis1.28357240
49MP0002138_abnormal_hepatobiliary_system1.27254594
50MP0005535_abnormal_body_temperature1.24544091
51MP0002254_reproductive_system_inflammat1.23228711
52MP0005375_adipose_tissue_phenotype1.22158097
53MP0005451_abnormal_body_composition1.20721720
54MP0002837_dystrophic_cardiac_calcinosis1.20683693
55MP0001188_hyperpigmentation1.19071777
56MP0004215_abnormal_myocardial_fiber1.17906258
57MP0003077_abnormal_cell_cycle1.17359350
58MP0005334_abnormal_fat_pad1.17045391
59MP0002938_white_spotting1.16462757
60MP0003718_maternal_effect1.16038835
61MP0000604_amyloidosis1.15979937
62MP0003941_abnormal_skin_development1.15598509
63MP0008932_abnormal_embryonic_tissue1.13323341
64MP0003111_abnormal_nucleus_morphology1.10767189
65MP0003329_amyloid_beta_deposits1.09976330
66MP0000343_altered_response_to1.09067298
67MP0002078_abnormal_glucose_homeostasis1.05213116
68MP0000920_abnormal_myelination1.04418657
69MP0005075_abnormal_melanosome_morpholog1.03822963
70MP0006072_abnormal_retinal_apoptosis1.02429422
71MP0000569_abnormal_digit_pigmentation1.01442700
72MP0002796_impaired_skin_barrier1.00874096
73MP0003136_yellow_coat_color1.00450365
74MP0008438_abnormal_cutaneous_collagen0.98584032
75MP0001881_abnormal_mammary_gland0.98355745
76MP0008789_abnormal_olfactory_epithelium0.95481592
77MP0003221_abnormal_cardiomyocyte_apopto0.95230266
78MP0005636_abnormal_mineral_homeostasis0.94770329
79MP0005647_abnormal_sex_gland0.94530721
80MP0003786_premature_aging0.91847187
81MP0000598_abnormal_liver_morphology0.91163167
82MP0004043_abnormal_pH_regulation0.90330421
83MP0005408_hypopigmentation0.90221333
84MP0002877_abnormal_melanocyte_morpholog0.89330964
85MP0009763_increased_sensitivity_to0.87887396
86MP0001324_abnormal_eye_pigmentation0.86861330
87MP0005448_abnormal_energy_balance0.84471012
88MP0001177_atelectasis0.84347961
89MP0002234_abnormal_pharynx_morphology0.83160146
90MP0003724_increased_susceptibility_to0.82363778
91MP0005253_abnormal_eye_physiology0.80725529
92MP0004782_abnormal_surfactant_physiolog0.79776827
93MP0009785_altered_susceptibility_to0.79766190
94MP0001542_abnormal_bone_strength0.79107854
95MP0005376_homeostasis/metabolism_phenot0.78942637
96MP0002970_abnormal_white_adipose0.78644862
97MP0009642_abnormal_blood_homeostasis0.77609137
98MP0009765_abnormal_xenobiotic_induced0.76802532
99MP0002638_abnormal_pupillary_reflex0.76771989
100MP0009115_abnormal_fat_cell0.76609639
101MP0001293_anophthalmia0.76416732
102MP0003959_abnormal_lean_body0.75654394
103MP0009703_decreased_birth_body0.75189610
104MP0004381_abnormal_hair_follicle0.75028298
105MP0005084_abnormal_gallbladder_morpholo0.74887591
106MP0009764_decreased_sensitivity_to0.73979123
107MP0000003_abnormal_adipose_tissue0.73758996
108MP0000013_abnormal_adipose_tissue0.73283759
109MP0001544_abnormal_cardiovascular_syste0.73034607
110MP0005385_cardiovascular_system_phenoty0.73034607
111MP0003705_abnormal_hypodermis_morpholog0.69207328
112MP0008469_abnormal_protein_level0.67623788
113MP0006138_congestive_heart_failure0.66633814
114MP0005266_abnormal_metabolism0.65869933
115MP0001756_abnormal_urination0.65804169
116MP0005275_abnormal_skin_tensile0.65759283
117MP0003137_abnormal_impulse_conducting0.62253074
118MP0006035_abnormal_mitochondrial_morpho0.62136480
119MP0000639_abnormal_adrenal_gland0.60261500
120MP0005452_abnormal_adipose_tissue0.60057961
121MP0003950_abnormal_plasma_membrane0.59513398
122MP0000579_abnormal_nail_morphology0.57690905
123MP0000427_abnormal_hair_cycle0.57472486
124MP0001186_pigmentation_phenotype0.57097812
125MP0000230_abnormal_systemic_arterial0.56542220
126MP0002282_abnormal_trachea_morphology0.55954940
127MP0005220_abnormal_exocrine_pancreas0.55593082
128MP0005058_abnormal_lysosome_morphology0.55250823
129MP0002233_abnormal_nose_morphology0.55225432
130MP0009379_abnormal_foot_pigmentation0.54718335
131MP0003953_abnormal_hormone_level0.53145046
132MP0008872_abnormal_physiological_respon0.49912186
133MP0002060_abnormal_skin_morphology0.49793062
134MP0002090_abnormal_vision0.47641570
135MP0000647_abnormal_sebaceous_gland0.46246772
136MP0008874_decreased_physiological_sensi0.44516200
137MP0005379_endocrine/exocrine_gland_phen0.43866071
138MP0003638_abnormal_response/metabolism_0.43741654
139MP0001243_abnormal_dermal_layer0.40404640
140MP0005164_abnormal_response_to0.40132060
141MP0002136_abnormal_kidney_physiology0.38821937
142MP0009780_abnormal_chondrocyte_physiolo0.37726292
143MP0004142_abnormal_muscle_tone0.36778657
144MP0010368_abnormal_lymphatic_system0.35312788
145MP0003633_abnormal_nervous_system0.35056013
146MP0002168_other_aberrant_phenotype0.34356938

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.39136261
2Intrahepatic cholestasis (HP:0001406)6.08536533
3Deep venous thrombosis (HP:0002625)5.58862240
4Xanthomatosis (HP:0000991)5.47718365
5Hyperlipoproteinemia (HP:0010980)5.15959719
6Hypobetalipoproteinemia (HP:0003563)4.96783206
7Prolonged partial thromboplastin time (HP:0003645)4.86639741
8Abnormality of monocarboxylic acid metabolism (HP:0010996)4.83177033
9Abnormality of serine family amino acid metabolism (HP:0010894)4.52260987
10Abnormality of glycine metabolism (HP:0010895)4.52260987
11Hyperglycinuria (HP:0003108)4.44720733
12Hyperammonemia (HP:0001987)4.43025436
13Complement deficiency (HP:0004431)4.40838133
14Ketosis (HP:0001946)4.37868562
15Epidermoid cyst (HP:0200040)4.35945232
16Acute necrotizing encephalopathy (HP:0006965)4.34182683
17Hyperglycinemia (HP:0002154)4.24107868
18Hypoglycemic coma (HP:0001325)4.20503559
19Abnormality of alanine metabolism (HP:0010916)4.16920653
20Hyperalaninemia (HP:0003348)4.16920653
21Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.16920653
22Abnormality of fatty-acid metabolism (HP:0004359)4.01204225
23Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.93784375
24Hypolipoproteinemia (HP:0010981)3.92512543
25Mitochondrial inheritance (HP:0001427)3.86455199
26Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.83511878
27Increased hepatocellular lipid droplets (HP:0006565)3.82099482
28Increased CSF lactate (HP:0002490)3.77670059
29Lipid accumulation in hepatocytes (HP:0006561)3.72199083
30Progressive macrocephaly (HP:0004481)3.66720261
31Fat malabsorption (HP:0002630)3.59843067
32Abnormality of glutamine family amino acid metabolism (HP:0010902)3.56292198
33Hypoalphalipoproteinemia (HP:0003233)3.52978224
34Abnormality of aspartate family amino acid metabolism (HP:0010899)3.50891050
35Exertional dyspnea (HP:0002875)3.50848265
36Ketoacidosis (HP:0001993)3.48186984
37Abnormality of methionine metabolism (HP:0010901)3.34886415
38Renal Fanconi syndrome (HP:0001994)3.33352430
39Congenital, generalized hypertrichosis (HP:0004540)3.28858617
40Cerebral edema (HP:0002181)3.26412837
41Dicarboxylic aciduria (HP:0003215)3.23244461
42Abnormality of dicarboxylic acid metabolism (HP:0010995)3.23244461
43Abnormality of the common coagulation pathway (HP:0010990)3.20515974
44Joint hemorrhage (HP:0005261)3.15915672
45Abnormality of serum amino acid levels (HP:0003112)3.14233084
46Abnormality of glycolysis (HP:0004366)3.11251657
47Increased serum pyruvate (HP:0003542)3.11251657
48Abnormality of sulfur amino acid metabolism (HP:0004339)3.09765174
49Abnormality of complement system (HP:0005339)3.08874131
50Conjugated hyperbilirubinemia (HP:0002908)3.03084794
51Increased serum lactate (HP:0002151)2.98205932
523-Methylglutaconic aciduria (HP:0003535)2.97850281
53Hypercholesterolemia (HP:0003124)2.96260923
54Lethargy (HP:0001254)2.95845204
55Steatorrhea (HP:0002570)2.92818580
56Reduced antithrombin III activity (HP:0001976)2.89027671
57Abnormality of the intrinsic pathway (HP:0010989)2.86567410
58Hyperbilirubinemia (HP:0002904)2.85985425
59CNS demyelination (HP:0007305)2.80738831
60Metabolic acidosis (HP:0001942)2.79197886
61Generalized aminoaciduria (HP:0002909)2.70580119
62Skin nodule (HP:0200036)2.70522918
63Respiratory failure (HP:0002878)2.65204927
64Hepatic necrosis (HP:0002605)2.63993024
65Delayed CNS myelination (HP:0002188)2.60249742
66Microvesicular hepatic steatosis (HP:0001414)2.57638880
67Brushfield spots (HP:0001088)2.55504947
68Abnormality of purine metabolism (HP:0004352)2.54624783
69Acute encephalopathy (HP:0006846)2.53395346
70Type I transferrin isoform profile (HP:0003642)2.50874311
71Degeneration of anterior horn cells (HP:0002398)2.50293741
72Abnormality of the anterior horn cell (HP:0006802)2.50293741
73Hypoglycemic seizures (HP:0002173)2.45604669
74Abnormal gallbladder physiology (HP:0012438)2.43056442
75Cholecystitis (HP:0001082)2.43056442
76Abnormality of nucleobase metabolism (HP:0010932)2.42923677
77Pancreatic islet-cell hyperplasia (HP:0004510)2.42483175
78Abnormal gallbladder morphology (HP:0012437)2.42211311
79Vomiting (HP:0002013)2.41594030
80Aplastic anemia (HP:0001915)2.41559431
81Myocardial infarction (HP:0001658)2.39593808
82Increased intramyocellular lipid droplets (HP:0012240)2.39300706
83Exercise intolerance (HP:0003546)2.38887917
84Colon cancer (HP:0003003)2.38501668
85Acanthocytosis (HP:0001927)2.34289666
86Decreased activity of mitochondrial respiratory chain (HP:0008972)2.34209086
87Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.34209086
88Leukodystrophy (HP:0002415)2.32432970
89Increased muscle lipid content (HP:0009058)2.29529466
90Amniotic constriction ring (HP:0009775)2.27160874
91Abnormality of placental membranes (HP:0011409)2.27160874
92Pancreatitis (HP:0001733)2.26482260
93Irritability (HP:0000737)2.26250504
94Gonadotropin excess (HP:0000837)2.22887618
95Cholelithiasis (HP:0001081)2.21863833
96Hypertriglyceridemia (HP:0002155)2.21777495
97Abnormality of pyrimidine metabolism (HP:0004353)2.19521463
98Hydroxyprolinuria (HP:0003080)2.19223326
99Abnormality of proline metabolism (HP:0010907)2.19223326
100Myoglobinuria (HP:0002913)2.17845495
101Rhabdomyolysis (HP:0003201)2.16163039
102Palpitations (HP:0001962)2.15973483
103Oligomenorrhea (HP:0000876)2.15398909
104Hepatocellular carcinoma (HP:0001402)2.11488470
105Vascular calcification (HP:0004934)2.10514409
106Amyloidosis (HP:0011034)2.10333437
107Abnormality of the labia minora (HP:0012880)2.09125781
108Abnormal biliary tract physiology (HP:0012439)2.06703328
109Bile duct proliferation (HP:0001408)2.06703328
110Neurofibrillary tangles (HP:0002185)2.06461618
111Glycosuria (HP:0003076)2.05225293
112Abnormality of urine glucose concentration (HP:0011016)2.05225293
113Neoplasm of the adrenal gland (HP:0100631)2.04134989
114Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.03468402
115Methylmalonic aciduria (HP:0012120)2.03076517
116Multiple enchondromatosis (HP:0005701)2.02743472
117Abnormality of renal resorption (HP:0011038)2.02401882
118Gout (HP:0001997)2.01167204
119Hepatocellular necrosis (HP:0001404)2.00839213
120Spontaneous abortion (HP:0005268)1.99880789
121Abnormal cartilage morphology (HP:0002763)1.99363320
122Optic disc pallor (HP:0000543)1.98357267
123Cerebral hemorrhage (HP:0001342)1.97377537
124Renal cortical cysts (HP:0000803)1.97238067
125Abnormal lung lobation (HP:0002101)1.96716241
126Acanthosis nigricans (HP:0000956)1.94260837
127Methylmalonic acidemia (HP:0002912)1.93881538
128Opisthotonus (HP:0002179)1.93633011
129Supernumerary spleens (HP:0009799)1.93202964
130Hyperinsulinemic hypoglycemia (HP:0000825)1.91473765
131Abnormality of chromosome stability (HP:0003220)1.88927768
132Cardiovascular calcification (HP:0011915)1.88830068
133Abnormality of the gallbladder (HP:0005264)1.88709224
134Spastic diplegia (HP:0001264)1.88565708
135Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.88436745
136Neonatal onset (HP:0003623)1.88374153
137Abnormal protein glycosylation (HP:0012346)1.85478206
138Abnormal glycosylation (HP:0012345)1.85478206
139Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.85478206
140Abnormal protein N-linked glycosylation (HP:0012347)1.85478206
141Elevated hepatic transaminases (HP:0002910)1.85132536
142Neoplasm of the colon (HP:0100273)1.85073382
143Abnormality of the vitamin B12 metabolism (HP:0004341)1.84754837
144Megaloblastic anemia (HP:0001889)1.84398750
145Abnormal mitochondria in muscle tissue (HP:0008316)1.83612994
146Symptomatic seizures (HP:0011145)1.82121686
147Hemorrhage of the eye (HP:0011885)1.82100321
148Spastic paraparesis (HP:0002313)1.81697047
149Lactic acidosis (HP:0003128)1.81582061
150Abnormality of vitamin metabolism (HP:0100508)1.81177634
151Epiphyseal stippling (HP:0010655)1.80321125
152Nausea (HP:0002018)1.79858520
153Abnormal hemoglobin (HP:0011902)1.79738496
154Enlarged kidneys (HP:0000105)1.79237243
155Hypoproteinemia (HP:0003075)1.78226183
156Hepatosplenomegaly (HP:0001433)1.72473856
157Reduced subcutaneous adipose tissue (HP:0003758)1.72350065
158Abnormality of vitamin B metabolism (HP:0004340)1.71149087
159Oral leukoplakia (HP:0002745)1.70171852
160Respiratory difficulties (HP:0002880)1.68636856
161Clitoromegaly (HP:0000057)1.67949095
162Medulloblastoma (HP:0002885)1.66681941
163Biliary tract neoplasm (HP:0100574)1.63979883

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.95777820
2SIK14.02791515
3STK393.24783802
4TRIM283.19190695
5BUB13.05540977
6INSRR2.96791009
7SRPK12.78449827
8VRK22.70254089
9EIF2AK32.68587835
10PDK42.61695914
11PDK32.61695914
12NEK12.47635883
13TSSK62.46857188
14MKNK12.43557522
15CAMK1D2.39522752
16OXSR12.35895203
17ZAK2.32116027
18MAP3K122.31832243
19EPHB12.30353422
20FGFR42.27647700
21ERN12.27332248
22ERBB32.26615503
23MST1R1.97267753
24STK161.95644397
25MET1.95627527
26ERBB41.91393754
27PLK31.89723021
28FGFR21.83135795
29MAP4K21.79759882
30MKNK21.79547230
31TRIB31.78607048
32NUAK11.75127249
33VRK11.71860100
34WNK41.67307709
35PIK3CG1.63786464
36MAPKAPK51.61085666
37EIF2AK11.60527356
38PRKAA21.59951566
39FLT31.58558775
40WNK31.57580694
41WEE11.56695911
42TTK1.50712873
43CAMK1G1.49513805
44ACVR1B1.48586376
45PLK41.46516266
46BRSK21.42363212
47MAP2K41.41966267
48BCR1.40693508
49TAOK31.37834432
50TAF11.35131603
51PDK21.30837024
52PBK1.29671747
53CCNB11.29505321
54MAPK111.25999138
55ABL21.25976784
56CDK61.24058488
57STK38L1.21037711
58MAP3K41.19757941
59CDC71.18925616
60NEK91.16025820
61PIK3CA1.14039710
62RPS6KA41.13056875
63PLK11.09299817
64EIF2AK21.06960371
65BMPR21.06062481
66FRK1.05065815
67PKN20.99537084
68DYRK30.99384698
69PDPK10.95743141
70CSNK1G10.94182100
71EPHB20.91961327
72TGFBR20.91681764
73IRAK10.90675568
74PKN10.90390781
75CSNK1G30.88392912
76NTRK10.86080260
77CAMK2G0.83003431
78MAP3K130.82932830
79TNIK0.82740871
80TGFBR10.81716929
81PRKCQ0.81432363
82IRAK20.80172455
83SGK2230.79503392
84SGK4940.79503392
85JAK20.79114755
86MAPK150.78332512
87AURKB0.76763225
88CSNK1A1L0.76654013
89GSK3A0.71707009
90DAPK20.71454856
91RET0.71352020
92PAK40.70574796
93CASK0.70068002
94LATS10.69571095
95NME10.67721585
96PDK10.67121102
97TESK10.66719791
98MAPK40.66514693
99CSNK1G20.66267402
100PRKACG0.66157618
101MAP3K30.62524249
102MAP2K70.60916833
103CDK190.60838215
104TIE10.60532129
105EPHA30.59640150
106CSNK2A10.59253241
107ATR0.57961643
108LIMK10.57924858
109GRK10.57490320
110MAP2K10.57418424
111CAMK2B0.57142823
112KIT0.56056647
113CSNK2A20.55306971
114ADRBK20.54995438
115IGF1R0.54862008
116PTK60.54671184
117JAK10.54288679
118CLK10.53236733
119PINK10.53065079
120PRKAA10.51476488
121STK240.51126967
122CDK30.49928900
123MAPK120.49903733
124PLK20.49337944
125MAP3K70.48405347
126PRKCZ0.46525111
127FGFR10.46243636
128TYK20.46211269
129EPHA40.45033173
130MAP3K20.44941622
131CSF1R0.44614576
132MYLK0.43487160
133PAK30.42291122
134CAMK2D0.41882407
135TBK10.40483905
136TEC0.40207900
137TXK0.40189982
138CHEK20.39678230
139PRKD10.39499965
140DAPK10.39158181
141ATM0.39004116
142MAP3K50.38563849
143KDR0.38540869
144DYRK20.36987140
145CSNK1E0.35840921
146MAP2K30.35717356
147TRPM70.35603767
148CDK90.34939960
149PASK0.34445338
150MAP2K60.33955979
151CDK140.33594819
152PRKACA0.33465586
153LMTK20.33064561
154RPS6KA50.32785729
155MST40.32126964
156OBSCN0.31468272
157MAP3K140.31118165
158PRKCE0.30096520
159KSR20.28014585
160LRRK20.26869237
161CAMK2A0.26620749
162BMPR1B0.26002971
163FER0.23942758
164DYRK1B0.23705518
165STK30.23624805

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.68195646
2Proteasome_Homo sapiens_hsa030503.22834486
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.08731844
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.03032800
5Nitrogen metabolism_Homo sapiens_hsa009103.02294946
6* Propanoate metabolism_Homo sapiens_hsa006402.91345528
7Fatty acid degradation_Homo sapiens_hsa000712.77568330
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.61979611
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.61566540
10Fatty acid metabolism_Homo sapiens_hsa012122.53361668
11Fatty acid elongation_Homo sapiens_hsa000622.46185651
12Butanoate metabolism_Homo sapiens_hsa006502.42709691
13Tryptophan metabolism_Homo sapiens_hsa003802.36390287
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.33835575
15Arginine biosynthesis_Homo sapiens_hsa002202.32609565
16PPAR signaling pathway_Homo sapiens_hsa033202.31020081
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.24473951
18Peroxisome_Homo sapiens_hsa041462.22099353
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.19503669
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.02361899
21Pyruvate metabolism_Homo sapiens_hsa006201.99787537
22Complement and coagulation cascades_Homo sapiens_hsa046101.96190313
23Mismatch repair_Homo sapiens_hsa034301.86711875
24Steroid biosynthesis_Homo sapiens_hsa001001.86244735
25Histidine metabolism_Homo sapiens_hsa003401.85471073
26Caffeine metabolism_Homo sapiens_hsa002321.85369220
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.84229207
28beta-Alanine metabolism_Homo sapiens_hsa004101.77500825
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.73423611
30Non-homologous end-joining_Homo sapiens_hsa034501.72487366
31Chemical carcinogenesis_Homo sapiens_hsa052041.70817044
32Sulfur metabolism_Homo sapiens_hsa009201.70543946
33RNA polymerase_Homo sapiens_hsa030201.66545212
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.66265198
35Fatty acid biosynthesis_Homo sapiens_hsa000611.64518845
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.62575665
37Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.52041903
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50805178
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.46675071
40Ribosome_Homo sapiens_hsa030101.46674886
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.46475575
42Retinol metabolism_Homo sapiens_hsa008301.44393890
43Tyrosine metabolism_Homo sapiens_hsa003501.42090123
44Phenylalanine metabolism_Homo sapiens_hsa003601.41259125
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.39675133
46Carbon metabolism_Homo sapiens_hsa012001.39497169
47DNA replication_Homo sapiens_hsa030301.39176233
48Drug metabolism - other enzymes_Homo sapiens_hsa009831.28488610
49Homologous recombination_Homo sapiens_hsa034401.27887519
50Fat digestion and absorption_Homo sapiens_hsa049751.22562513
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.21912900
52Nucleotide excision repair_Homo sapiens_hsa034201.21046563
53Folate biosynthesis_Homo sapiens_hsa007901.16952580
54Basal transcription factors_Homo sapiens_hsa030221.16802470
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.15802884
56Selenocompound metabolism_Homo sapiens_hsa004501.14196956
57Starch and sucrose metabolism_Homo sapiens_hsa005001.12968524
58Vitamin B6 metabolism_Homo sapiens_hsa007501.12702108
59Staphylococcus aureus infection_Homo sapiens_hsa051501.11975578
60Glycerolipid metabolism_Homo sapiens_hsa005611.09234757
61Bile secretion_Homo sapiens_hsa049761.08714353
62Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.08058917
63Biosynthesis of amino acids_Homo sapiens_hsa012301.06352529
64Cysteine and methionine metabolism_Homo sapiens_hsa002701.00168139
65ABC transporters_Homo sapiens_hsa020100.99191904
66Asthma_Homo sapiens_hsa053100.95182295
67Spliceosome_Homo sapiens_hsa030400.94728473
68RNA degradation_Homo sapiens_hsa030180.93652361
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90869158
70RNA transport_Homo sapiens_hsa030130.90083197
71Arginine and proline metabolism_Homo sapiens_hsa003300.89564164
72Base excision repair_Homo sapiens_hsa034100.87706235
73Pyrimidine metabolism_Homo sapiens_hsa002400.87662515
74Fanconi anemia pathway_Homo sapiens_hsa034600.86570020
75Sulfur relay system_Homo sapiens_hsa041220.84419618
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.81963882
77Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81202543
78Glutathione metabolism_Homo sapiens_hsa004800.81014448
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74240728
80Pentose phosphate pathway_Homo sapiens_hsa000300.68649238
81Purine metabolism_Homo sapiens_hsa002300.68461784
82Vitamin digestion and absorption_Homo sapiens_hsa049770.67505105
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.65940510
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65650281
85Metabolic pathways_Homo sapiens_hsa011000.61408677
86Cyanoamino acid metabolism_Homo sapiens_hsa004600.59745944
87Linoleic acid metabolism_Homo sapiens_hsa005910.57383571
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57225657
89Oxidative phosphorylation_Homo sapiens_hsa001900.55780247
90Lysine degradation_Homo sapiens_hsa003100.47369518
91Cell cycle_Homo sapiens_hsa041100.44642021
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.43408872
93Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.41141802
94Allograft rejection_Homo sapiens_hsa053300.38056330
95Parkinsons disease_Homo sapiens_hsa050120.37680300
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37096668
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.36516653
98Autoimmune thyroid disease_Homo sapiens_hsa053200.34504632
99Protein export_Homo sapiens_hsa030600.31702474
100Type I diabetes mellitus_Homo sapiens_hsa049400.29256450
101Alzheimers disease_Homo sapiens_hsa050100.28624237
102Graft-versus-host disease_Homo sapiens_hsa053320.28312720
103p53 signaling pathway_Homo sapiens_hsa041150.28196051
104AMPK signaling pathway_Homo sapiens_hsa041520.25089372
105Ether lipid metabolism_Homo sapiens_hsa005650.24741832
106Intestinal immune network for IgA production_Homo sapiens_hsa046720.24224482
107Renin-angiotensin system_Homo sapiens_hsa046140.22968626
108Insulin resistance_Homo sapiens_hsa049310.22633884
109Cardiac muscle contraction_Homo sapiens_hsa042600.22283808
110Antigen processing and presentation_Homo sapiens_hsa046120.20392029
111Galactose metabolism_Homo sapiens_hsa000520.19956166
112Glucagon signaling pathway_Homo sapiens_hsa049220.10577322
113Prion diseases_Homo sapiens_hsa050200.10232789
114Fructose and mannose metabolism_Homo sapiens_hsa000510.08145671
115Ovarian steroidogenesis_Homo sapiens_hsa049130.06860108
116One carbon pool by folate_Homo sapiens_hsa006700.06158415
117Arachidonic acid metabolism_Homo sapiens_hsa005900.04812532
118Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.03952768
119Huntingtons disease_Homo sapiens_hsa050160.03806042
120SNARE interactions in vesicular transport_Homo sapiens_hsa04130-0.1987181
121Sphingolipid metabolism_Homo sapiens_hsa00600-0.1941900
122Protein digestion and absorption_Homo sapiens_hsa04974-0.1897870
123Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1786633
124Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1762692
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1708844
126Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1598630
127Lysosome_Homo sapiens_hsa04142-0.1460741
128Regulation of autophagy_Homo sapiens_hsa04140-0.0507936
129Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524-0.0235422
130Insulin signaling pathway_Homo sapiens_hsa04910-0.0054326

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