EBLN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of female gonad development (GO:2000194)9.60429555
2piRNA metabolic process (GO:0034587)8.94538075
3meiotic cell cycle (GO:0051321)8.28326638
4regulation of meiosis I (GO:0060631)8.14884401
5regulation of acrosome reaction (GO:0060046)7.34621480
6oocyte development (GO:0048599)7.14729735
7DNA methylation involved in gamete generation (GO:0043046)6.82358317
8female gamete generation (GO:0007292)6.70169155
9retinal cone cell development (GO:0046549)6.53110189
10regulation of histone H3-K9 methylation (GO:0051570)6.44415055
11positive regulation of histone H3-K4 methylation (GO:0051571)6.37340163
12multicellular organism reproduction (GO:0032504)6.18532418
13glycine transport (GO:0015816)6.15689610
14regulation of cell maturation (GO:1903429)5.52065932
15synapsis (GO:0007129)5.48457432
16regulation of steroid hormone secretion (GO:2000831)5.41521061
17gene silencing by RNA (GO:0031047)5.40956374
18mitotic chromosome condensation (GO:0007076)5.38097337
19negative regulation of histone methylation (GO:0031061)5.21648056
20negative regulation of reproductive process (GO:2000242)5.19004712
21positive regulation of mitotic sister chromatid separation (GO:1901970)5.01985304
22positive regulation of mitotic metaphase/anaphase transition (GO:0045842)5.01985304
23positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)5.01985304
24protein localization to chromosome, centromeric region (GO:0071459)4.99181017
25positive regulation of gastrulation (GO:2000543)4.88088901
26protein kinase C signaling (GO:0070528)4.83361883
27protein localization to kinetochore (GO:0034501)4.80883425
28centriole replication (GO:0007099)4.78362526
29mitotic metaphase plate congression (GO:0007080)4.76947650
30synaptonemal complex assembly (GO:0007130)4.68845668
31positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.64870840
32chromosome organization involved in meiosis (GO:0070192)4.59866079
33positive regulation of chromosome segregation (GO:0051984)4.55881510
34histone H3-K9 demethylation (GO:0033169)4.48677217
35L-amino acid import (GO:0043092)4.43816616
36regulation of meiosis (GO:0040020)4.40407267
37establishment of chromosome localization (GO:0051303)4.35860357
38attachment of spindle microtubules to kinetochore (GO:0008608)4.34412643
39positive regulation of humoral immune response (GO:0002922)4.26448704
40male meiosis I (GO:0007141)4.25775388
41primitive streak formation (GO:0090009)4.20984458
42synaptonemal complex organization (GO:0070193)4.20316164
43male meiosis (GO:0007140)4.15764018
44oogenesis (GO:0048477)4.06774218
45CENP-A containing nucleosome assembly (GO:0034080)4.05218712
46reproduction (GO:0000003)4.03274806
47positive regulation of histone methylation (GO:0031062)3.96139988
48nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.94809031
49protein localization to chromosome (GO:0034502)3.93790637
50translesion synthesis (GO:0019985)3.90210233
51positive regulation of uterine smooth muscle contraction (GO:0070474)3.84528121
52metaphase plate congression (GO:0051310)3.83928418
53labyrinthine layer development (GO:0060711)3.80406085
54phosphorelay signal transduction system (GO:0000160)3.75455976
55positive regulation of reproductive process (GO:2000243)3.74175360
56meiotic nuclear division (GO:0007126)3.72463691
57regulation of histone H3-K4 methylation (GO:0051569)3.69123601
58regulation of meiotic cell cycle (GO:0051445)3.68457714
59meiotic cell cycle process (GO:1903046)3.67311588
60regulation of spindle organization (GO:0090224)3.66349980
61chromatin remodeling at centromere (GO:0031055)3.66342890
62fertilization (GO:0009566)3.65684331
63regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.62004763
64DNA alkylation (GO:0006305)3.57916234
65DNA methylation (GO:0006306)3.57916234
66regulation of steroid hormone biosynthetic process (GO:0090030)3.56873217
67DNA replication-dependent nucleosome assembly (GO:0006335)3.56569169
68DNA replication-dependent nucleosome organization (GO:0034723)3.56569169
69relaxation of smooth muscle (GO:0044557)3.52199867
70gene silencing (GO:0016458)3.51507458
71DNA damage induced protein phosphorylation (GO:0006975)3.51248635
72phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.50535956
73meiosis I (GO:0007127)3.48551501
74regulation of spindle checkpoint (GO:0090231)3.45230215
75regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.40847524
76regulation of histone methylation (GO:0031060)3.36180382
77positive regulation of meiosis (GO:0045836)3.35046673
78negative regulation of cAMP-mediated signaling (GO:0043951)3.34346413
79negative regulation of execution phase of apoptosis (GO:1900118)3.32257531
80binding of sperm to zona pellucida (GO:0007339)3.32254675
81regulation of double-strand break repair via homologous recombination (GO:0010569)3.31676025
82somite rostral/caudal axis specification (GO:0032525)3.31581337
83centriole assembly (GO:0098534)3.28546021
84N-terminal protein amino acid acetylation (GO:0006474)3.25429578
85negative regulation of hormone biosynthetic process (GO:0032353)3.19168423
86regulation of reproductive process (GO:2000241)3.18870439
87regulation of chromatin silencing (GO:0031935)3.17221186
88histone exchange (GO:0043486)3.17160892
89DNA replication-independent nucleosome assembly (GO:0006336)3.15987081
90DNA replication-independent nucleosome organization (GO:0034724)3.15987081
91single fertilization (GO:0007338)3.15165628
92negative regulation of hormone metabolic process (GO:0032351)3.13456495
93positive regulation of meiotic cell cycle (GO:0051446)3.11652444
94neuron fate determination (GO:0048664)3.10591416
95regulation of female receptivity (GO:0045924)3.03776475
96negative regulation of histone modification (GO:0031057)3.02956174
97regulation of cytokine production involved in inflammatory response (GO:1900015)2.99434111
98amino acid import (GO:0043090)2.98294403
99chromatin assembly or disassembly (GO:0006333)2.96903971
100regulation of DNA methylation (GO:0044030)11.4942659

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.72482840
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.63702445
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.46212786
4E2F7_22180533_ChIP-Seq_HELA_Human3.80574324
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.46385474
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.46385474
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.46385474
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.12742286
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.88519292
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.74121972
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.71004049
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.60440098
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.58197225
14HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.30516470
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.22813654
16GBX2_23144817_ChIP-Seq_PC3_Human2.18472055
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.17009486
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.00970086
19EZH2_22144423_ChIP-Seq_EOC_Human13.4536293
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.92381610
21GATA1_26923725_Chip-Seq_HPCs_Mouse1.68410086
22E2F4_17652178_ChIP-ChIP_JURKAT_Human1.68341580
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.53483918
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50379508
25AR_21909140_ChIP-Seq_LNCAP_Human1.47208532
26IRF1_19129219_ChIP-ChIP_H3396_Human1.43704304
27EP300_21415370_ChIP-Seq_HL-1_Mouse1.42185403
28TP63_19390658_ChIP-ChIP_HaCaT_Human1.41746860
29TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39139737
30UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.34333369
31CBP_20019798_ChIP-Seq_JUKART_Human1.32058921
32IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32058921
33ESR1_15608294_ChIP-ChIP_MCF-7_Human1.31956037
34PRDM14_20953172_ChIP-Seq_ESCs_Human1.28161487
35TCF4_23295773_ChIP-Seq_U87_Human1.26484610
36RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26393861
37HTT_18923047_ChIP-ChIP_STHdh_Human1.12865313
38FOXM1_26456572_ChIP-Seq_MCF-7_Human1.11625155
39AR_25329375_ChIP-Seq_VCAP_Human1.11187758
40SMAD4_21799915_ChIP-Seq_A2780_Human1.10650957
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08919687
42STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.06475966
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.06161168
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.03972926
45EWS_26573619_Chip-Seq_HEK293_Human1.02793982
46CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.01141658
47NANOG_20526341_ChIP-Seq_ESCs_Human1.01087479
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99877995
49STAT3_23295773_ChIP-Seq_U87_Human0.99661454
50LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99267993
51SMAD4_21741376_ChIP-Seq_EPCs_Human0.98664037
52RUNX2_22187159_ChIP-Seq_PCA_Human0.98368241
53CBP_21632823_ChIP-Seq_H3396_Human0.98257538
54GF1_26923725_Chip-Seq_HPCs_Mouse0.96431072
55KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.94473394
56LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93800055
57EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.92824720
58TP53_16413492_ChIP-PET_HCT116_Human0.92022963
59CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.91932432
60TAL1_26923725_Chip-Seq_HPCs_Mouse0.91163161
61SALL1_21062744_ChIP-ChIP_HESCs_Human0.90488209
62CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89805576
63FOXH1_21741376_ChIP-Seq_EPCs_Human0.88896933
64P300_19829295_ChIP-Seq_ESCs_Human0.88759846
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.88622341
66SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87623673
67TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.87474153
68GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86681235
69BMI1_23680149_ChIP-Seq_NPCS_Mouse0.85375993
70SALL4_22934838_ChIP-ChIP_CD34+_Human0.85328724
71KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.83904611
72AHR_22903824_ChIP-Seq_MCF-7_Human0.83754020
73TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.81786471
74SMRT_27268052_Chip-Seq_Bcells_Human0.80374938
75CREB1_15753290_ChIP-ChIP_HEK293T_Human0.80175927
76PKCTHETA_26484144_Chip-Seq_BREAST_Human0.79722603
77NR3C1_23031785_ChIP-Seq_PC12_Mouse0.79001014
78PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.77882468
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.77511151
80MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.77399153
81RNF2_27304074_Chip-Seq_NSC_Mouse0.77146030
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76755136
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.76755136
84VDR_22108803_ChIP-Seq_LS180_Human0.74762521
85GATA1_19941827_ChIP-Seq_MEL86_Mouse0.73132155
86TP53_22573176_ChIP-Seq_HFKS_Human0.72670429
87POU3F2_20337985_ChIP-ChIP_501MEL_Human0.69017502
88GATA3_26560356_Chip-Seq_TH1_Human0.68191176
89EZH2_27304074_Chip-Seq_ESCs_Mouse0.68189956
90SMAD3_21741376_ChIP-Seq_EPCs_Human0.67821450
91AUTS2_25519132_ChIP-Seq_293T-REX_Human0.67512346
92REST_21632747_ChIP-Seq_MESCs_Mouse0.65689277
93DROSHA_22980978_ChIP-Seq_HELA_Human0.65508209
94NANOG_18555785_ChIP-Seq_MESCs_Mouse0.64967721
95CTBP2_25329375_ChIP-Seq_LNCAP_Human0.64564546
96STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.64468246
97PADI4_21655091_ChIP-ChIP_MCF-7_Human0.64146378
98ZNF217_24962896_ChIP-Seq_MCF-7_Human0.64117442
99ARNT_22903824_ChIP-Seq_MCF-7_Human0.63821423
100SOX2_21211035_ChIP-Seq_LN229_Gbm0.63752648

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect8.43948924
2MP0008877_abnormal_DNA_methylation4.80699826
3MP0006292_abnormal_olfactory_placode4.47469029
4MP0008789_abnormal_olfactory_epithelium4.21182762
5MP0005499_abnormal_olfactory_system3.73200043
6MP0005394_taste/olfaction_phenotype3.73200043
7MP0005395_other_phenotype3.37179587
8MP0010234_abnormal_vibrissa_follicle3.16652118
9MP0002139_abnormal_hepatobiliary_system3.13102452
10MP0003890_abnormal_embryonic-extraembry3.11735688
11MP0005360_urolithiasis3.07924131
12MP0008057_abnormal_DNA_replication2.81617113
13MP0003693_abnormal_embryo_hatching2.70203472
14MP0002138_abnormal_hepatobiliary_system2.67843668
15MP0003699_abnormal_female_reproductive2.47805370
16MP0003879_abnormal_hair_cell2.46313089
17MP0010030_abnormal_orbit_morphology2.43762392
18MP0002210_abnormal_sex_determination2.28088760
19MP0001929_abnormal_gametogenesis2.27770549
20MP0002234_abnormal_pharynx_morphology2.24779945
21MP0003950_abnormal_plasma_membrane2.09886582
22MP0003077_abnormal_cell_cycle2.05005547
23MP0003183_abnormal_peptide_metabolism1.95782978
24MP0010094_abnormal_chromosome_stability1.92054094
25MP0005410_abnormal_fertilization1.90120389
26MP0008058_abnormal_DNA_repair1.87000947
27MP0002160_abnormal_reproductive_system1.82941475
28MP0000653_abnormal_sex_gland1.76861804
29MP0002161_abnormal_fertility/fecundity1.64807372
30MP0000566_synostosis1.55245368
31MP0003111_abnormal_nucleus_morphology1.50296463
32MP0001145_abnormal_male_reproductive1.45352534
33MP0009840_abnormal_foam_cell1.34131897
34MP0005647_abnormal_sex_gland1.32244115
35MP0000427_abnormal_hair_cycle1.31964908
36MP0008932_abnormal_embryonic_tissue1.31518500
37MP0005646_abnormal_pituitary_gland1.30557457
38MP0010307_abnormal_tumor_latency1.29852200
39MP0001293_anophthalmia1.29362771
40MP0001119_abnormal_female_reproductive1.27081146
41MP0000631_abnormal_neuroendocrine_gland1.25184544
42MP0000762_abnormal_tongue_morphology1.24585497
43MP0003698_abnormal_male_reproductive1.24014952
44MP0003252_abnormal_bile_duct1.22368925
45MP0003121_genomic_imprinting1.21199760
46MP0001730_embryonic_growth_arrest1.19330858
47MP0005389_reproductive_system_phenotype1.13728685
48MP0001984_abnormal_olfaction1.10786797
49MP0002233_abnormal_nose_morphology1.08084209
50MP0010678_abnormal_skin_adnexa1.07880618
51MP0004142_abnormal_muscle_tone1.06450952
52MP0009379_abnormal_foot_pigmentation1.00907312
53MP0006276_abnormal_autonomic_nervous1.00267439
54MP0010368_abnormal_lymphatic_system1.00007836
55MP0003119_abnormal_digestive_system0.98314576
56MP0001986_abnormal_taste_sensitivity0.94707650
57MP0000678_abnormal_parathyroid_gland0.93836097
58MP0002272_abnormal_nervous_system0.90573344
59MP0005085_abnormal_gallbladder_physiolo0.85558467
60MP0005380_embryogenesis_phenotype0.84443311
61MP0001672_abnormal_embryogenesis/_devel0.84443311
62MP0000350_abnormal_cell_proliferation0.83745371
63MP0003136_yellow_coat_color0.82413352
64MP0001664_abnormal_digestion0.81618014
65MP0002796_impaired_skin_barrier0.78986250
66MP0001666_abnormal_nutrient_absorption0.75436139
67MP0003868_abnormal_feces_composition0.74992462
68MP0000049_abnormal_middle_ear0.72366469
69MP0001502_abnormal_circadian_rhythm0.70034243
70MP0005551_abnormal_eye_electrophysiolog0.68968243
71MP0001324_abnormal_eye_pigmentation0.64987194
72MP0004957_abnormal_blastocyst_morpholog0.61522144
73MP0005501_abnormal_skin_physiology0.60852456
74MP0003941_abnormal_skin_development0.60468703
75MP0000015_abnormal_ear_pigmentation0.56015988
76MP0001963_abnormal_hearing_physiology0.55559042
77MP0002084_abnormal_developmental_patter0.54587717
78MP0005075_abnormal_melanosome_morpholog0.53689459
79MP0002089_abnormal_postnatal_growth/wei0.51832098
80MP0002127_abnormal_cardiovascular_syste0.48487845
81MP0002090_abnormal_vision0.45230372
82MP0005503_abnormal_tendon_morphology0.42428198
83MP0003935_abnormal_craniofacial_develop0.42237184
84MP0006138_congestive_heart_failure0.42057263
85MP0002751_abnormal_autonomic_nervous0.41947471
86MP0002928_abnormal_bile_duct0.41429847
87MP0005076_abnormal_cell_differentiation0.41008042
88MP0000377_abnormal_hair_follicle0.40535988
89MP0004043_abnormal_pH_regulation0.39473663
90MP0004381_abnormal_hair_follicle0.39318170
91MP0002085_abnormal_embryonic_tissue0.38819837
92MP0003959_abnormal_lean_body0.35935402
93MP0001697_abnormal_embryo_size0.35755526
94MP0002873_normal_phenotype0.35362957
95MP0001881_abnormal_mammary_gland0.35258685
96MP0002169_no_abnormal_phenotype0.34905912
97MP0008995_early_reproductive_senescence0.34878712
98MP0000383_abnormal_hair_follicle0.34305621
99MP0002735_abnormal_chemical_nociception0.34058539
100MP0003936_abnormal_reproductive_system0.33918882

Predicted human phenotypes

RankGene SetZ-score
1Supernumerary spleens (HP:0009799)6.50257804
2Osteomalacia (HP:0002749)5.23078978
3Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)5.06085386
4Abnormality of abdominal situs (HP:0011620)5.03632609
5Abdominal situs inversus (HP:0003363)5.03632609
6Abnormal gallbladder physiology (HP:0012438)5.02374754
7Cholecystitis (HP:0001082)5.02374754
8Facial hemangioma (HP:0000329)5.00768945
9Male infertility (HP:0003251)4.53738464
10Lip pit (HP:0100267)4.52190951
11Oligodactyly (hands) (HP:0001180)4.50339959
12Hypophosphatemic rickets (HP:0004912)4.44333693
13Hypoplasia of the fovea (HP:0007750)4.11991486
14Aplasia/Hypoplasia of the fovea (HP:0008060)4.11991486
15Papillary thyroid carcinoma (HP:0002895)4.11430078
16Premature ovarian failure (HP:0008209)4.06256859
17Impulsivity (HP:0100710)4.02140779
18Azoospermia (HP:0000027)3.96643543
19Median cleft lip (HP:0000161)3.91905009
20Malnutrition (HP:0004395)3.90372736
21Septo-optic dysplasia (HP:0100842)3.89326687
22Anterior segment dysgenesis (HP:0007700)3.78828217
23Infertility (HP:0000789)3.70199441
24Short tibia (HP:0005736)3.67418764
25Abnormality of the fovea (HP:0000493)3.59700156
26Chromsome breakage (HP:0040012)3.53113023
27Absent septum pellucidum (HP:0001331)3.51149426
28Gonadotropin excess (HP:0000837)3.48597477
29Abnormality of the labia minora (HP:0012880)3.46866215
30Chromosomal breakage induced by crosslinking agents (HP:0003221)3.42345808
31Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.33267863
32Aplasia/Hypoplasia of the tibia (HP:0005772)3.27168203
33Oligodactyly (HP:0012165)3.19600893
34Wrist flexion contracture (HP:0001239)3.11954704
35Enlarged penis (HP:0000040)3.09377020
36Abnormality of the septum pellucidum (HP:0007375)3.02208054
37Capillary hemangiomas (HP:0005306)3.00785297
38Conjunctival telangiectasia (HP:0000524)2.96092579
39Abnormal spermatogenesis (HP:0008669)2.94023250
40Apathy (HP:0000741)2.86318310
41Urethral obstruction (HP:0000796)2.84801288
42Hypokinesia (HP:0002375)2.84161972
43Diminished motivation (HP:0000745)2.80089665
44Fair hair (HP:0002286)2.78870526
45Muscle stiffness (HP:0003552)2.76002277
46Spinal cord compression (HP:0002176)2.68188219
47Loss of speech (HP:0002371)2.62462713
48Aplasia/Hypoplasia of the macula (HP:0008059)2.61376934
49Metaphyseal irregularity (HP:0003025)2.59770076
50Stillbirth (HP:0003826)2.59267638
51Sensory axonal neuropathy (HP:0003390)2.49820828
52Proximal tubulopathy (HP:0000114)2.48506949
53Abnormality of the phalanges of the hallux (HP:0010057)2.43232822
54Skin pits (HP:0100276)2.38899490
55Generalized aminoaciduria (HP:0002909)2.38840368
56Aplasia/Hypoplasia affecting the retina (HP:0008061)2.38438706
57Truncal obesity (HP:0001956)2.38050843
58Intrahepatic cholestasis (HP:0001406)2.36882752
59Lower limb hyperreflexia (HP:0002395)2.35093107
60Aplasia of the musculature (HP:0100854)2.31625155
61Abnormality of the vasculature of the conjunctiva (HP:0008054)2.31506124
62Ankle contracture (HP:0006466)2.31338246
63Myokymia (HP:0002411)2.30731856
64Aplasia/Hypoplasia of the tongue (HP:0010295)2.28338417
65Thyroid carcinoma (HP:0002890)2.25997063
66Abnormal lung lobation (HP:0002101)2.23818603
67Congenital sensorineural hearing impairment (HP:0008527)2.22756781
68Maternal diabetes (HP:0009800)2.22714090
69Bile duct proliferation (HP:0001408)2.19080736
70Abnormal biliary tract physiology (HP:0012439)2.19080736
71Bundle branch block (HP:0011710)2.15141079
72Anhidrosis (HP:0000970)2.15028259
73Abnormal ciliary motility (HP:0012262)2.14492950
74Dysdiadochokinesis (HP:0002075)2.13324034
75Abnormality of calcium-phosphate metabolism (HP:0100530)2.12097739
76Striae distensae (HP:0001065)2.09619849
77Heterotopia (HP:0002282)2.02571856
78Microglossia (HP:0000171)2.01012296
79Hydroureter (HP:0000072)2.00090649
80Nephroblastoma (Wilms tumor) (HP:0002667)2.00038150
81Generalized hypopigmentation of hair (HP:0011358)1.97220183
82Hip contracture (HP:0003273)1.96822594
83Posterior subcapsular cataract (HP:0007787)1.95939950
84Abnormality of aromatic amino acid family metabolism (HP:0004338)1.94604885
85Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.93025257
86Cranial hyperostosis (HP:0004437)1.91827097
87Rhinitis (HP:0012384)1.91591747
88Limb hypertonia (HP:0002509)1.90424352
89Abnormality of chromosome stability (HP:0003220)1.90308118
90Embryonal renal neoplasm (HP:0011794)1.87114567
91Abnormality of chromosome segregation (HP:0002916)1.86749180
92Bicornuate uterus (HP:0000813)1.84542058
93Aplasia/Hypoplasia of the uvula (HP:0010293)1.83237751
94Rickets (HP:0002748)1.80299203
95Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.80282493
96Abnormality of monocarboxylic acid metabolism (HP:0010996)1.79034549
97Hypohidrosis (HP:0000966)1.76119010
98Steatorrhea (HP:0002570)1.75261042
99Duodenal stenosis (HP:0100867)1.75186042
100Small intestinal stenosis (HP:0012848)1.75186042

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K96.68133529
2ARAF6.30195663
3MAP3K136.19519883
4STK243.27279964
5BRAF3.13536717
6NEK63.08362611
7MOS2.83957456
8MET2.80904486
9TTK2.73417205
10TAOK32.71565472
11KSR22.23003288
12CDK92.18508310
13AURKA2.10397439
14RAF12.05559932
15CDK121.84947371
16CDC71.78788624
17EIF2AK31.73310192
18PRKCI1.58923706
19TNIK1.46326117
20NTRK21.43163285
21CDK71.35226807
22KSR11.34287852
23STK31.28124055
24ZAK1.26024509
25TRIM281.22516591
26PLK11.22168257
27CDK191.17349598
28MELK1.13911537
29NEK91.04668847
30BUB10.97100016
31PIM10.96698432
32NUAK10.95316056
33MAP3K80.95031105
34PTK20.84775602
35NEK20.84167445
36STK390.80218290
37BRSK10.75556301
38TIE10.74628478
39PLK30.73179016
40DMPK0.71799998
41CHEK10.71641952
42MST40.71433898
43TNK20.69954837
44WNK10.69477764
45BMPR1B0.67720468
46CDK20.63482767
47CHEK20.62841357
48MAPKAPK30.61911430
49MARK30.61031361
50NTRK30.59108958
51AURKB0.54914728
52CSNK1G10.54492117
53VRK10.54315340
54CDK80.53460622
55ACVR1B0.52853984
56BRSK20.51582454
57PRKG10.50914337
58ATM0.48335484
59PAK10.47459758
60CSNK1D0.46493209
61TGFBR10.45187175
62PKN10.44902998
63CDK10.43387743
64ATR0.41329708
65OXSR10.40157897
66MAPK130.39931528
67SRPK10.38272396
68LRRK20.37053993
69EEF2K0.36713431
70TLK10.34506438
71MAP3K50.33148222
72PRKCZ0.31343338
73CSNK1E0.31223593
74CDK50.31132002
75PDK10.30513026
76MTOR0.30147029
77CAMK2A0.30065237
78TYRO30.29430834
79CSNK1G30.29419511
80PLK40.29195378
81MAP3K40.26999162
82TRPM70.24600245
83PRKACB0.24010330
84LMTK20.23864290
85PBK0.23706076
86LATS10.23352446
87PNCK0.23296436
88PRKACA0.21730591
89EGFR0.21526280
90MAPK10.19234424
91AKT20.18779756
92GSK3B0.17416869
93CSF1R0.17371770
94CHUK0.17100537
95MAP2K10.17060339
96CDK11A0.16216341
97CSNK1G20.14404049
98MAP3K10.13993358
99PDPK10.13135131
100CSNK1A1L0.11935970

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030225.52611443
2Cell cycle_Homo sapiens_hsa041104.51473298
3Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005334.15667197
4Mismatch repair_Homo sapiens_hsa034304.03050798
5Oocyte meiosis_Homo sapiens_hsa041143.52142007
6Caffeine metabolism_Homo sapiens_hsa002323.29767415
7RNA degradation_Homo sapiens_hsa030182.94698404
8Base excision repair_Homo sapiens_hsa034102.90964682
9Ovarian steroidogenesis_Homo sapiens_hsa049132.84263276
10Dorso-ventral axis formation_Homo sapiens_hsa043202.61554589
11Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.56370073
12DNA replication_Homo sapiens_hsa030302.44200784
13Nucleotide excision repair_Homo sapiens_hsa034202.39974259
14Fanconi anemia pathway_Homo sapiens_hsa034602.25133874
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.23985710
16Homologous recombination_Homo sapiens_hsa034402.19556802
17Olfactory transduction_Homo sapiens_hsa047402.07566382
18Cysteine and methionine metabolism_Homo sapiens_hsa002702.01701674
19RNA transport_Homo sapiens_hsa030131.86523568
20Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.81405135
21Circadian rhythm_Homo sapiens_hsa047101.78492774
22p53 signaling pathway_Homo sapiens_hsa041151.65465154
23Folate biosynthesis_Homo sapiens_hsa007901.62253263
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.43451621
25Thyroid cancer_Homo sapiens_hsa052161.32242931
26Gap junction_Homo sapiens_hsa045401.30247237
27Phototransduction_Homo sapiens_hsa047441.22022181
28RNA polymerase_Homo sapiens_hsa030201.20003669
29mRNA surveillance pathway_Homo sapiens_hsa030151.13366528
30Nicotine addiction_Homo sapiens_hsa050331.09718244
31ABC transporters_Homo sapiens_hsa020101.00849838
32SNARE interactions in vesicular transport_Homo sapiens_hsa041300.98338275
33Bile secretion_Homo sapiens_hsa049760.93011300
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83952497
35Morphine addiction_Homo sapiens_hsa050320.83235086
36Inositol phosphate metabolism_Homo sapiens_hsa005620.82102294
37Fatty acid elongation_Homo sapiens_hsa000620.80940794
38GABAergic synapse_Homo sapiens_hsa047270.76317767
39Synaptic vesicle cycle_Homo sapiens_hsa047210.69305652
40Taste transduction_Homo sapiens_hsa047420.65352075
41Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64616896
42Viral carcinogenesis_Homo sapiens_hsa052030.63791577
43mTOR signaling pathway_Homo sapiens_hsa041500.63484120
44Long-term depression_Homo sapiens_hsa047300.62223588
45TGF-beta signaling pathway_Homo sapiens_hsa043500.61610026
46Serotonergic synapse_Homo sapiens_hsa047260.56417696
47Vitamin digestion and absorption_Homo sapiens_hsa049770.54839434
48Purine metabolism_Homo sapiens_hsa002300.54027099
49FoxO signaling pathway_Homo sapiens_hsa040680.51548678
50Adherens junction_Homo sapiens_hsa045200.48895600
51Glycosaminoglycan degradation_Homo sapiens_hsa005310.47906688
52Small cell lung cancer_Homo sapiens_hsa052220.47730578
53Herpes simplex infection_Homo sapiens_hsa051680.45006142
54Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44654362
55HTLV-I infection_Homo sapiens_hsa051660.43663436
56MicroRNAs in cancer_Homo sapiens_hsa052060.42511115
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41062122
58ErbB signaling pathway_Homo sapiens_hsa040120.39739263
59Regulation of autophagy_Homo sapiens_hsa041400.38017771
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33437947
61Aldosterone synthesis and secretion_Homo sapiens_hsa049250.27196281
62Ras signaling pathway_Homo sapiens_hsa040140.26830207
63Oxytocin signaling pathway_Homo sapiens_hsa049210.26377598
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.25977591
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.23383376
66Hippo signaling pathway_Homo sapiens_hsa043900.21764372
67Wnt signaling pathway_Homo sapiens_hsa043100.19604922
68Endometrial cancer_Homo sapiens_hsa052130.18592469
69cAMP signaling pathway_Homo sapiens_hsa040240.17709061
70Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.17525005
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.17455238
72Protein digestion and absorption_Homo sapiens_hsa049740.17302526
73Non-homologous end-joining_Homo sapiens_hsa034500.16727142
74Linoleic acid metabolism_Homo sapiens_hsa005910.14864625
75Arginine biosynthesis_Homo sapiens_hsa002200.14369190
76Cholinergic synapse_Homo sapiens_hsa047250.14277252
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.14254983
78Pyrimidine metabolism_Homo sapiens_hsa002400.14033510
79Huntingtons disease_Homo sapiens_hsa050160.13861376
80Arginine and proline metabolism_Homo sapiens_hsa003300.13417094
81Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.12564778
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.12456974
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.12245512
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.11745515
85Spliceosome_Homo sapiens_hsa030400.11461989
86Long-term potentiation_Homo sapiens_hsa047200.10013709
87Propanoate metabolism_Homo sapiens_hsa006400.09445310
88MAPK signaling pathway_Homo sapiens_hsa040100.09331451
89Colorectal cancer_Homo sapiens_hsa052100.08741066
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.08590340
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.08130262
92Hepatitis B_Homo sapiens_hsa051610.08122668
93Renal cell carcinoma_Homo sapiens_hsa052110.07252690
94Circadian entrainment_Homo sapiens_hsa047130.06350121
95Non-small cell lung cancer_Homo sapiens_hsa052230.05952864
96Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.05886279
97Glutamatergic synapse_Homo sapiens_hsa047240.05736917
98Phagosome_Homo sapiens_hsa041450.04950361
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.04609629
100Tight junction_Homo sapiens_hsa045300.04111028

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