EBAG9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene was identified as an estrogen-responsive gene. Regulation of transcription by estrogen is mediated by estrogen receptor, which binds to the estrogen-responsive element found in the 5'-flanking region of this gene. The encoded protein is a tumor-associated antigen that is expressed at high frequency in a variety of cancers. Alternate splicing results in multiple transcript variants. A pseudogene of this gene has been defined on chromosome 10. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lysine metabolic process (GO:0006553)5.64319413
2lysine catabolic process (GO:0006554)5.64319413
3L-phenylalanine metabolic process (GO:0006558)5.64222058
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.64222058
5L-phenylalanine catabolic process (GO:0006559)5.51368337
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.51368337
7DNA double-strand break processing (GO:0000729)5.19592062
8succinate metabolic process (GO:0006105)5.11730472
9fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.85510493
10oxaloacetate metabolic process (GO:0006107)4.77475723
11cellular ketone body metabolic process (GO:0046950)4.60138326
12aromatic amino acid family catabolic process (GO:0009074)4.58773600
13cysteine metabolic process (GO:0006534)4.46331112
14NADH metabolic process (GO:0006734)4.22077419
15tricarboxylic acid cycle (GO:0006099)4.21458151
16alpha-linolenic acid metabolic process (GO:0036109)4.20932529
17short-chain fatty acid metabolic process (GO:0046459)4.14686336
18aspartate family amino acid catabolic process (GO:0009068)4.05855625
19urea cycle (GO:0000050)4.05057646
20urea metabolic process (GO:0019627)4.05057646
21proteasome assembly (GO:0043248)4.03224041
22kynurenine metabolic process (GO:0070189)4.00199898
23bile acid biosynthetic process (GO:0006699)3.97376669
24resolution of meiotic recombination intermediates (GO:0000712)3.96702617
25ketone body metabolic process (GO:1902224)3.91514488
26synapsis (GO:0007129)3.90996400
27branched-chain amino acid catabolic process (GO:0009083)3.86214643
282-oxoglutarate metabolic process (GO:0006103)3.85248583
29mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.84582078
30protein K11-linked deubiquitination (GO:0035871)3.82251652
31sulfur amino acid catabolic process (GO:0000098)3.78291870
32tryptophan catabolic process (GO:0006569)3.77612503
33indole-containing compound catabolic process (GO:0042436)3.77612503
34indolalkylamine catabolic process (GO:0046218)3.77612503
35exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.76372575
36chromatin remodeling at centromere (GO:0031055)3.74802939
37respiratory chain complex IV assembly (GO:0008535)3.73739630
38alpha-amino acid catabolic process (GO:1901606)3.72779190
39regulation of DNA endoreduplication (GO:0032875)3.70511166
40nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.69850533
41fatty acid beta-oxidation (GO:0006635)3.69391999
42CENP-A containing nucleosome assembly (GO:0034080)3.66781923
43glutamate metabolic process (GO:0006536)3.65495278
44branched-chain amino acid metabolic process (GO:0009081)3.62422649
45tryptophan metabolic process (GO:0006568)3.60934180
46fatty acid oxidation (GO:0019395)3.60788456
47nitrogen cycle metabolic process (GO:0071941)3.59687064
48cellular amino acid catabolic process (GO:0009063)3.54780967
49DNA catabolic process, exonucleolytic (GO:0000738)3.50164212
50regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.49799593
51lipid oxidation (GO:0034440)3.49551468
52glyoxylate metabolic process (GO:0046487)3.47008374
53protein complex biogenesis (GO:0070271)3.44815394
54fatty acid catabolic process (GO:0009062)3.43061161
55triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.40794983
56drug catabolic process (GO:0042737)3.39796608
57regulation of mitochondrial translation (GO:0070129)3.37325293
58regulation of meiosis I (GO:0060631)3.37278758
59nucleoside diphosphate biosynthetic process (GO:0009133)3.36273468
60aromatic amino acid family metabolic process (GO:0009072)3.35001422
61cellular modified amino acid catabolic process (GO:0042219)3.34406367
62amino-acid betaine metabolic process (GO:0006577)3.33662275
63monocarboxylic acid catabolic process (GO:0072329)3.32675286
64homocysteine metabolic process (GO:0050667)3.30811797
65mitochondrial respiratory chain complex assembly (GO:0033108)3.30134341
66mitotic metaphase plate congression (GO:0007080)3.29897047
67cytochrome complex assembly (GO:0017004)3.29842045
68coenzyme catabolic process (GO:0009109)3.28870481
69oxidative phosphorylation (GO:0006119)3.28557156
70tyrosine metabolic process (GO:0006570)3.26271854
71mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.25775858
72mitochondrial respiratory chain complex I assembly (GO:0032981)3.25775858
73NADH dehydrogenase complex assembly (GO:0010257)3.25775858
74meiotic chromosome segregation (GO:0045132)3.24957849
75cullin deneddylation (GO:0010388)3.23223975
76carboxylic acid catabolic process (GO:0046395)3.20299791
77organic acid catabolic process (GO:0016054)3.20299791
78microtubule depolymerization (GO:0007019)3.20064286
79regulation of protein activation cascade (GO:2000257)3.19885576
80DNA replication checkpoint (GO:0000076)3.18842621
81pseudouridine synthesis (GO:0001522)3.18840370
82centriole replication (GO:0007099)3.18190937
83mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.16915697
84metaphase plate congression (GO:0051310)3.16827668
85imidazole-containing compound metabolic process (GO:0052803)3.16411048
86regulation of acyl-CoA biosynthetic process (GO:0050812)3.14946561
87bile acid metabolic process (GO:0008206)3.14073301
88negative regulation of DNA-dependent DNA replication (GO:2000104)3.13979717
89regulation of cofactor metabolic process (GO:0051193)3.13939019
90regulation of coenzyme metabolic process (GO:0051196)3.13939019
91establishment of protein localization to mitochondrial membrane (GO:0090151)3.13306409
92intestinal cholesterol absorption (GO:0030299)3.12815419
93histone exchange (GO:0043486)3.10623625
94protein neddylation (GO:0045116)3.10347104
95kinetochore organization (GO:0051383)3.07696103
96fatty acid transmembrane transport (GO:1902001)3.07688962
97regulation of sulfur metabolic process (GO:0042762)3.06412123
98benzene-containing compound metabolic process (GO:0042537)3.06237480
99regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.05960864
100exogenous drug catabolic process (GO:0042738)3.05894347
101piRNA metabolic process (GO:0034587)3.04462217
102telomere maintenance via semi-conservative replication (GO:0032201)3.04246061
103dicarboxylic acid metabolic process (GO:0043648)3.04108728
104regulation of mitotic spindle checkpoint (GO:1903504)3.03199277
105regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.03199277
106protein-cofactor linkage (GO:0018065)3.02715782
107negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.01711403
108carnitine shuttle (GO:0006853)3.01387780
109valine metabolic process (GO:0006573)3.01358390
110protein K6-linked ubiquitination (GO:0085020)3.00469058
111disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.00354240
112killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.00354240
113regulation of complement activation (GO:0030449)2.99876803
114inositol phosphate dephosphorylation (GO:0046855)2.99825643
115phosphorylated carbohydrate dephosphorylation (GO:0046838)2.99825643
116regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.99073679
117serine family amino acid catabolic process (GO:0009071)2.98333975
118positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.96253276
119dicarboxylic acid biosynthetic process (GO:0043650)2.96209671
120replication fork processing (GO:0031297)2.95576327
121peptidyl-glutamic acid carboxylation (GO:0017187)2.95547720
122protein carboxylation (GO:0018214)2.95547720
123glycine metabolic process (GO:0006544)2.95274448
124ATP synthesis coupled proton transport (GO:0015986)2.92972479
125energy coupled proton transport, down electrochemical gradient (GO:0015985)2.92972479
126COPI coating of Golgi vesicle (GO:0048205)2.92380886
127Golgi transport vesicle coating (GO:0048200)2.92380886
128serine family amino acid metabolic process (GO:0009069)2.91951132
129urate metabolic process (GO:0046415)2.91559162
130drug transmembrane transport (GO:0006855)2.90613932
131anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.90432564
132DNA ligation (GO:0006266)2.88772954
133postreplication repair (GO:0006301)2.88610367
134organelle disassembly (GO:1903008)2.88406882
135negative regulation of fibrinolysis (GO:0051918)2.86614363
136regulation of fibrinolysis (GO:0051917)2.86539742
137protein deneddylation (GO:0000338)2.86492939
138RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.86356072
139male meiosis (GO:0007140)2.86102904
140tricarboxylic acid metabolic process (GO:0072350)2.85184100
141histone mRNA metabolic process (GO:0008334)2.82916190
142NAD metabolic process (GO:0019674)2.82620435
143regulation of centriole replication (GO:0046599)2.82563029
144chaperone-mediated protein transport (GO:0072321)2.82551584
145biotin metabolic process (GO:0006768)2.82547889
146maturation of 5.8S rRNA (GO:0000460)2.82109325
147acylglycerol homeostasis (GO:0055090)2.80666688
148triglyceride homeostasis (GO:0070328)2.80666688
149protein K11-linked ubiquitination (GO:0070979)2.79510509
150respiratory electron transport chain (GO:0022904)2.79484243
151rRNA catabolic process (GO:0016075)2.78108819
152electron transport chain (GO:0022900)2.74805286
153establishment of integrated proviral latency (GO:0075713)2.74591191
154acetyl-CoA metabolic process (GO:0006084)2.74550618
155regulation of hexokinase activity (GO:1903299)2.74412247
156regulation of glucokinase activity (GO:0033131)2.74412247
157epoxygenase P450 pathway (GO:0019373)2.74282508
158complement activation, alternative pathway (GO:0006957)2.70930828
159proline biosynthetic process (GO:0006561)2.70504733
160ethanol oxidation (GO:0006069)2.69834946
161translesion synthesis (GO:0019985)2.68617442
162tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.68404704
163RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.68404704
164mismatch repair (GO:0006298)2.68010971
165microtubule polymerization or depolymerization (GO:0031109)2.67555854
166chromosome organization involved in meiosis (GO:0070192)2.64963252
167regulation of cellular amino acid metabolic process (GO:0006521)2.64409449
168protein targeting to mitochondrion (GO:0006626)2.64147846
169positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.63771771
170kinetochore assembly (GO:0051382)2.63583831
171ribonucleoprotein complex disassembly (GO:0032988)2.62916044
172negative regulation of ligase activity (GO:0051352)2.62863836
173negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.62863836
174maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.60857141
175mitochondrial DNA replication (GO:0006264)2.60721459
176telomere maintenance via recombination (GO:0000722)2.59178729
177spermatid nucleus differentiation (GO:0007289)2.58147678
178peptidyl-histidine modification (GO:0018202)2.56133905
179rRNA modification (GO:0000154)2.56126711
180DNA replication-independent nucleosome assembly (GO:0006336)2.54975166
181DNA replication-independent nucleosome organization (GO:0034724)2.54975166
182protein localization to mitochondrion (GO:0070585)2.53658930
183positive regulation of ligase activity (GO:0051351)2.53141560
184spliceosomal snRNP assembly (GO:0000387)2.52654038
185nucleotide-excision repair, DNA gap filling (GO:0006297)2.52647965
186meiotic cell cycle (GO:0051321)2.51455866
187regulation of double-strand break repair via homologous recombination (GO:0010569)2.49741016
188centriole assembly (GO:0098534)2.48162979
189mitotic recombination (GO:0006312)2.47618376
190negative regulation of DNA recombination (GO:0045910)2.46388636
191transcription from mitochondrial promoter (GO:0006390)2.44708687
192male meiosis I (GO:0007141)2.44306960

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.01776999
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.25749544
3PPARA_22158963_ChIP-Seq_LIVER_Mouse3.70967177
4EGR1_23403033_ChIP-Seq_LIVER_Mouse3.60118888
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.25346110
6RBPJ_22232070_ChIP-Seq_NCS_Mouse3.17240617
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.15027776
8GATA1_22025678_ChIP-Seq_K562_Human3.11618166
9LXR_22158963_ChIP-Seq_LIVER_Mouse2.91484002
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.77174044
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.52030798
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.46732627
13FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.34170407
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.31178165
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.29310311
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.22517605
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.22379148
18PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.19783839
19CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.18026365
20ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.13500994
21HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.09411952
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.07984471
23NOTCH1_21737748_ChIP-Seq_TLL_Human1.99831192
24SALL1_21062744_ChIP-ChIP_HESCs_Human1.98363521
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.94962160
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.84856108
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.82860617
28VDR_22108803_ChIP-Seq_LS180_Human1.80013112
29GABP_17652178_ChIP-ChIP_JURKAT_Human1.73882507
30* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.73862519
31PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.73624667
32TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.72565731
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72193964
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.68636414
35PADI4_21655091_ChIP-ChIP_MCF-7_Human1.65095215
36IGF1R_20145208_ChIP-Seq_DFB_Human1.64449712
37* VDR_23849224_ChIP-Seq_CD4+_Human1.62472074
38SRF_21415370_ChIP-Seq_HL-1_Mouse1.62016978
39TAF15_26573619_Chip-Seq_HEK293_Human1.60728339
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58906760
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.55743630
42ZFX_18555785_ChIP-Seq_MESCs_Mouse1.54498529
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.54289682
44HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.53424378
45E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.51914470
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.49217791
47ELK1_19687146_ChIP-ChIP_HELA_Human1.48362035
48ETS1_20019798_ChIP-Seq_JURKAT_Human1.47041183
49FUS_26573619_Chip-Seq_HEK293_Human1.43942706
50KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.43651834
51DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.42766040
52* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41272409
53FOXP3_21729870_ChIP-Seq_TREG_Human1.40891705
54JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.39060582
55ER_23166858_ChIP-Seq_MCF-7_Human1.38960776
56RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36750385
57AR_21909140_ChIP-Seq_LNCAP_Human1.36651731
58SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.36280139
59TP53_22573176_ChIP-Seq_HFKS_Human1.34646594
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.33981549
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.31357664
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29563286
63* GABP_19822575_ChIP-Seq_HepG2_Human1.27926457
64* DCP1A_22483619_ChIP-Seq_HELA_Human1.27547276
65NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.26694476
66EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25430464
67MYC_18358816_ChIP-ChIP_MESCs_Mouse1.25292181
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24796520
69CBP_20019798_ChIP-Seq_JUKART_Human1.24796520
70MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.23871689
71CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.23606464
72YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23412192
73ZNF274_21170338_ChIP-Seq_K562_Hela1.22116001
74BCAT_22108803_ChIP-Seq_LS180_Human1.21753510
75FLI1_27457419_Chip-Seq_LIVER_Mouse1.20235998
76E2F1_18555785_ChIP-Seq_MESCs_Mouse1.18093745
77EZH2_27294783_Chip-Seq_NPCs_Mouse1.16853032
78POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16430655
79MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.16156245
80GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.15591049
81CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15139624
82ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15027515
83CIITA_25753668_ChIP-Seq_RAJI_Human1.14231677
84GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12901793
85CLOCK_20551151_ChIP-Seq_293T_Human1.11128057
86FOXM1_23109430_ChIP-Seq_U2OS_Human1.10644893
87HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.09938010
88CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09617170
89CREB1_15753290_ChIP-ChIP_HEK293T_Human1.09447596
90UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09351108
91MYC_19030024_ChIP-ChIP_MESCs_Mouse1.08526698
92RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05215118
93HTT_18923047_ChIP-ChIP_STHdh_Human1.04652184
94E2F7_22180533_ChIP-Seq_HELA_Human1.04530367
95GATA3_26560356_Chip-Seq_TH1_Human1.04418169
96MYC_19079543_ChIP-ChIP_MESCs_Mouse1.04014855
97FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04004013
98KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03859341
99BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.02679696
100MYCN_18555785_ChIP-Seq_MESCs_Mouse1.02505275
101SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01746790
102SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01336817
103RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.01041779
104MYC_22102868_ChIP-Seq_BL_Human1.00823161
105SOX2_19829295_ChIP-Seq_ESCs_Human1.00638348
106NANOG_19829295_ChIP-Seq_ESCs_Human1.00638348
107ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00362009
108* MYC_18940864_ChIP-ChIP_HL60_Human1.00316423
109NFE2_27457419_Chip-Seq_LIVER_Mouse1.00298829
110* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99968368
111E2F4_17652178_ChIP-ChIP_JURKAT_Human0.99295294
112AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98680367
113TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98205201
114GBX2_23144817_ChIP-Seq_PC3_Human0.96727070
115ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.96252921
116* FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95727427
117CRX_20693478_ChIP-Seq_RETINA_Mouse0.95580868
118EWS_26573619_Chip-Seq_HEK293_Human0.95270034
119E2F1_21310950_ChIP-Seq_MCF-7_Human0.94297198
120MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94129484
121FOXA1_25329375_ChIP-Seq_VCAP_Human0.92512122
122FOXA1_27270436_Chip-Seq_PROSTATE_Human0.92512122
123MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91864795
124STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.91742274
125THAP11_20581084_ChIP-Seq_MESCs_Mouse0.91676471
126IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.91004009
127AR_25329375_ChIP-Seq_VCAP_Human0.90075665
128* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.87524544
129P300_19829295_ChIP-Seq_ESCs_Human0.87305050
130NELFA_20434984_ChIP-Seq_ESCs_Mouse0.87100564
131SCL_19346495_ChIP-Seq_HPC-7_Human0.85705663
132KDM5A_27292631_Chip-Seq_BREAST_Human0.84868566
133SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.83640956
134CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.82219667
135LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.81687046
136AR_20517297_ChIP-Seq_VCAP_Human0.79990698
137HNF4A_19822575_ChIP-Seq_HepG2_Human0.79746011
138LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.78464871
139MYB_21317192_ChIP-Seq_ERMYB_Mouse0.77994346
140TTF2_22483619_ChIP-Seq_HELA_Human0.77599596
141* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.74786463
142ERG_20517297_ChIP-Seq_VCAP_Human0.74723189
143* GATA3_27048872_Chip-Seq_THYMUS_Human0.74714667
144IRF1_19129219_ChIP-ChIP_H3396_Human0.72672574

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.81920784
2MP0005360_urolithiasis5.59169652
3MP0008875_abnormal_xenobiotic_pharmacok5.14542754
4MP0005085_abnormal_gallbladder_physiolo4.85086710
5MP0005365_abnormal_bile_salt4.79737466
6MP0008877_abnormal_DNA_methylation3.99793837
7MP0003718_maternal_effect3.34693075
8MP0002837_dystrophic_cardiac_calcinosis3.33549824
9MP0008057_abnormal_DNA_replication3.23052659
10MP0003252_abnormal_bile_duct3.17223238
11MP0003806_abnormal_nucleotide_metabolis3.07483493
12MP0003693_abnormal_embryo_hatching3.02534210
13MP0005083_abnormal_biliary_tract2.87318862
14MP0000569_abnormal_digit_pigmentation2.80648048
15MP0001984_abnormal_olfaction2.76467678
16MP0001666_abnormal_nutrient_absorption2.66390671
17MP0010329_abnormal_lipoprotein_level2.61895562
18MP0010094_abnormal_chromosome_stability2.58302140
19MP0005332_abnormal_amino_acid2.54628213
20MP0003787_abnormal_imprinting2.41464230
21MP0009697_abnormal_copulation2.35548264
22MP0006036_abnormal_mitochondrial_physio2.27037115
23MP0005220_abnormal_exocrine_pancreas2.21285894
24MP0003868_abnormal_feces_composition2.05569462
25MP0003646_muscle_fatigue1.98523580
26MP0005084_abnormal_gallbladder_morpholo1.97434003
27MP0008789_abnormal_olfactory_epithelium1.88408822
28MP0006072_abnormal_retinal_apoptosis1.87771874
29MP0002138_abnormal_hepatobiliary_system1.86644088
30MP0003880_abnormal_central_pattern1.82440173
31MP0003121_genomic_imprinting1.80710930
32MP0006035_abnormal_mitochondrial_morpho1.69683402
33MP0000372_irregular_coat_pigmentation1.65884339
34MP0005319_abnormal_enzyme/_coenzyme1.62438693
35MP0003077_abnormal_cell_cycle1.61518510
36MP0009384_cardiac_valve_regurgitation1.61056966
37MP0000609_abnormal_liver_physiology1.60969465
38MP0002234_abnormal_pharynx_morphology1.55642019
39MP0004147_increased_porphyrin_level1.53325360
40MP0002210_abnormal_sex_determination1.51572751
41MP0005584_abnormal_enzyme/coenzyme_acti1.51274431
42MP0001929_abnormal_gametogenesis1.51173667
43MP0008995_early_reproductive_senescence1.49891179
44MP0002396_abnormal_hematopoietic_system1.48523181
45MP0001764_abnormal_homeostasis1.47924171
46MP0002090_abnormal_vision1.47095558
47MP0004043_abnormal_pH_regulation1.46313345
48MP0003786_premature_aging1.43676852
49MP0002928_abnormal_bile_duct1.42847421
50MP0009046_muscle_twitch1.42458898
51MP0002160_abnormal_reproductive_system1.40867663
52MP0003195_calcinosis1.38912871
53MP0005551_abnormal_eye_electrophysiolog1.38312355
54MP0003111_abnormal_nucleus_morphology1.37070282
55MP0002118_abnormal_lipid_homeostasis1.35931868
56MP0008007_abnormal_cellular_replicative1.33260262
57MP0003656_abnormal_erythrocyte_physiolo1.30873955
58MP0002693_abnormal_pancreas_physiology1.28436897
59MP0004130_abnormal_muscle_cell1.27007219
60MP0002876_abnormal_thyroid_physiology1.24145972
61MP0000653_abnormal_sex_gland1.23661098
62MP0005499_abnormal_olfactory_system1.21319087
63MP0005394_taste/olfaction_phenotype1.21319087
64MP0001145_abnormal_male_reproductive1.20782136
65MP0003122_maternal_imprinting1.20510059
66MP0001944_abnormal_pancreas_morphology1.20175982
67MP0004142_abnormal_muscle_tone1.19902090
68MP0005389_reproductive_system_phenotype1.17586838
69MP0009643_abnormal_urine_homeostasis1.16946582
70MP0003698_abnormal_male_reproductive1.15004053
71MP0000598_abnormal_liver_morphology1.14989229
72MP0008932_abnormal_embryonic_tissue1.14722969
73MP0005636_abnormal_mineral_homeostasis1.14370887
74MP0002822_catalepsy1.13440481
75MP0002078_abnormal_glucose_homeostasis1.12623160
76MP0005395_other_phenotype1.12208234
77MP0002163_abnormal_gland_morphology1.11366399
78MP0005253_abnormal_eye_physiology1.10287262
79MP0003123_paternal_imprinting1.10170152
80MP0006054_spinal_hemorrhage1.10114135
81MP0008961_abnormal_basal_metabolism1.06603898
82MP0001873_stomach_inflammation1.06195448
83MP0006276_abnormal_autonomic_nervous1.05644521
84MP0002938_white_spotting1.03616857
85MP0004215_abnormal_myocardial_fiber1.03530248
86MP0000013_abnormal_adipose_tissue1.02788972
87MP0005535_abnormal_body_temperature1.02688877
88MP0000427_abnormal_hair_cycle1.01798327
89MP0002971_abnormal_brown_adipose1.01256392
90MP0005187_abnormal_penis_morphology0.99262775
91MP0003191_abnormal_cellular_cholesterol0.94293450
92MP0010234_abnormal_vibrissa_follicle0.93313935
93MP0002166_altered_tumor_susceptibility0.93042704
94MP0004957_abnormal_blastocyst_morpholog0.92243181
95MP0006292_abnormal_olfactory_placode0.91967807
96MP0005174_abnormal_tail_pigmentation0.89650702
97MP0004145_abnormal_muscle_electrophysio0.89366474
98MP0001293_anophthalmia0.88988750
99MP0001919_abnormal_reproductive_system0.88855564
100MP0005075_abnormal_melanosome_morpholog0.88478628
101MP0005646_abnormal_pituitary_gland0.88265101
102MP0003186_abnormal_redox_activity0.87732312
103MP0005410_abnormal_fertilization0.87509764
104MP0002877_abnormal_melanocyte_morpholog0.85955546
105MP0009642_abnormal_blood_homeostasis0.85923798
106MP0002272_abnormal_nervous_system0.84428658
107MP0001529_abnormal_vocalization0.83999414
108MP0000631_abnormal_neuroendocrine_gland0.82304594
109MP0003221_abnormal_cardiomyocyte_apopto0.81663868
110MP0000383_abnormal_hair_follicle0.81613731
111MP0010678_abnormal_skin_adnexa0.81368728
112MP0001765_abnormal_ion_homeostasis0.81169182
113MP0005645_abnormal_hypothalamus_physiol0.80925070
114MP0005367_renal/urinary_system_phenotyp0.80321568
115MP0000516_abnormal_urinary_system0.80321568
116MP0002229_neurodegeneration0.79508195
117MP0008775_abnormal_heart_ventricle0.79440984
118MP0006138_congestive_heart_failure0.78713843
119MP0004510_myositis0.78368337
120MP0002909_abnormal_adrenal_gland0.77079366
121MP0001119_abnormal_female_reproductive0.76453720
122MP0002095_abnormal_skin_pigmentation0.76447579
123MP0000604_amyloidosis0.75653268
124MP0000639_abnormal_adrenal_gland0.75549795
125MP0003879_abnormal_hair_cell0.75222341
126MP0005448_abnormal_energy_balance0.73547436
127MP0002161_abnormal_fertility/fecundity0.73226703
128MP0003959_abnormal_lean_body0.72424606
129MP0003638_abnormal_response/metabolism_0.72212223
130MP0003567_abnormal_fetal_cardiomyocyte0.72139597
131MP0004084_abnormal_cardiac_muscle0.71552694
132MP0002269_muscular_atrophy0.69178379
133MP0005379_endocrine/exocrine_gland_phen0.68901015
134MP0004484_altered_response_of0.68609653
135MP0001324_abnormal_eye_pigmentation0.68332090
136MP0002653_abnormal_ependyma_morphology0.67926054
137MP0000358_abnormal_cell_content/0.67028415
138MP0002132_abnormal_respiratory_system0.66554376
139MP0008469_abnormal_protein_level0.66254928
140MP0004808_abnormal_hematopoietic_stem0.66021314
141MP0003136_yellow_coat_color0.65905817
142MP0001905_abnormal_dopamine_level0.65603309
143MP0005266_abnormal_metabolism0.65264692
144MP0003890_abnormal_embryonic-extraembry0.65019934
145MP0004036_abnormal_muscle_relaxation0.64824661
146MP0005408_hypopigmentation0.63300046
147MP0004264_abnormal_extraembryonic_tissu0.63106932
148MP0001664_abnormal_digestion0.61251520
149MP0005330_cardiomyopathy0.60957663
150MP0005671_abnormal_response_to0.60571077
151MP0005376_homeostasis/metabolism_phenot0.57858538
152MP0003329_amyloid_beta_deposits0.57440808
153MP0005058_abnormal_lysosome_morphology0.54420357
154MP0009763_increased_sensitivity_to0.54104067
155MP0003953_abnormal_hormone_level0.53504645
156MP0004019_abnormal_vitamin_homeostasis0.51952062
157MP0008058_abnormal_DNA_repair0.50023164
158MP0000003_abnormal_adipose_tissue0.49627055
159MP0004233_abnormal_muscle_weight0.48816931
160MP0005310_abnormal_salivary_gland0.46678984
161MP0005334_abnormal_fat_pad0.45366575
162MP0000749_muscle_degeneration0.44818663
163MP0005464_abnormal_platelet_physiology0.44460240
164MP0001845_abnormal_inflammatory_respons0.43670479
165MP0002135_abnormal_kidney_morphology0.42655488
166MP0009672_abnormal_birth_weight0.40717466
167MP0000689_abnormal_spleen_morphology0.40681152

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.11993021
2Hyperammonemia (HP:0001987)4.26715611
3Ketosis (HP:0001946)4.15557080
4Hypoglycemic coma (HP:0001325)4.07379346
5Hypobetalipoproteinemia (HP:0003563)3.94891909
6Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.88276664
7Ragged-red muscle fibers (HP:0003200)3.84196755
8Ketoacidosis (HP:0001993)3.77570685
9Abnormality of monocarboxylic acid metabolism (HP:0010996)3.72479845
10Prolonged partial thromboplastin time (HP:0003645)3.69679435
11Abnormality of the intrinsic pathway (HP:0010989)3.60218626
12Deep venous thrombosis (HP:0002625)3.58916386
13Hyperglycinemia (HP:0002154)3.57483840
14Abnormality of the labia minora (HP:0012880)3.55425932
15Intrahepatic cholestasis (HP:0001406)3.52660609
16Increased hepatocellular lipid droplets (HP:0006565)3.36667856
17Gout (HP:0001997)3.28649584
18Abnormality of fatty-acid metabolism (HP:0004359)3.23463193
19Cerebral edema (HP:0002181)3.22926440
20Hepatic necrosis (HP:0002605)3.22842603
21Abnormal mitochondria in muscle tissue (HP:0008316)3.18223273
22Metabolic acidosis (HP:0001942)3.17366631
23Hyperventilation (HP:0002883)3.17036753
24Acute encephalopathy (HP:0006846)3.15692374
25Palpitations (HP:0001962)3.06551085
263-Methylglutaconic aciduria (HP:0003535)3.05706407
27Abnormality of dicarboxylic acid metabolism (HP:0010995)3.04614023
28Dicarboxylic aciduria (HP:0003215)3.04614023
29Abnormality of the common coagulation pathway (HP:0010990)3.00092468
30Abnormality of serum amino acid levels (HP:0003112)2.93313157
31Hepatocellular necrosis (HP:0001404)2.89420649
32Lethargy (HP:0001254)2.87943516
33Acute necrotizing encephalopathy (HP:0006965)2.86629153
34Pancreatic fibrosis (HP:0100732)2.85966446
35Abnormality of glycine metabolism (HP:0010895)2.82676898
36Abnormality of serine family amino acid metabolism (HP:0010894)2.82676898
37Generalized aminoaciduria (HP:0002909)2.82622049
38Hyperbilirubinemia (HP:0002904)2.81302226
39Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.79025194
40Abnormality of alanine metabolism (HP:0010916)2.79025194
41Hyperalaninemia (HP:0003348)2.79025194
42Chromsome breakage (HP:0040012)2.75513684
43Increased CSF lactate (HP:0002490)2.75093030
44Abnormality of aspartate family amino acid metabolism (HP:0010899)2.73713629
45Conjugated hyperbilirubinemia (HP:0002908)2.71650949
46Hyperlipoproteinemia (HP:0010980)2.65414685
47Abnormality of purine metabolism (HP:0004352)2.64402331
48Medial flaring of the eyebrow (HP:0010747)2.63142556
49Pancreatic cysts (HP:0001737)2.62981240
50Lactic acidosis (HP:0003128)2.61769340
51Abnormality of sulfur amino acid metabolism (HP:0004339)2.61272889
52Hypolipoproteinemia (HP:0010981)2.61261314
53Abnormality of chromosome stability (HP:0003220)2.57307145
54Acute hepatic failure (HP:0006554)2.55965861
55Xanthomatosis (HP:0000991)2.55111379
56Meckel diverticulum (HP:0002245)2.54186748
57Hypoglycemic seizures (HP:0002173)2.53964261
58Methylmalonic aciduria (HP:0012120)2.53953666
59Hyperglycinuria (HP:0003108)2.53108733
60Exertional dyspnea (HP:0002875)2.52308240
61True hermaphroditism (HP:0010459)2.51806728
62Mitochondrial inheritance (HP:0001427)2.51672681
63Renal Fanconi syndrome (HP:0001994)2.50666027
64Chromosomal breakage induced by crosslinking agents (HP:0003221)2.49521616
65Abnormality of methionine metabolism (HP:0010901)2.47839484
66Abnormality of midbrain morphology (HP:0002418)2.46483834
67Molar tooth sign on MRI (HP:0002419)2.46483834
68Lipid accumulation in hepatocytes (HP:0006561)2.41835025
69Abnormality of the ileum (HP:0001549)2.41182232
70Exercise intolerance (HP:0003546)2.40305707
71Aplasia/Hypoplasia of the uvula (HP:0010293)2.38449173
72Progressive macrocephaly (HP:0004481)2.35475537
73Chronic hepatic failure (HP:0100626)2.35342922
74Increased muscle lipid content (HP:0009058)2.34150942
75Abnormality of the preputium (HP:0100587)2.33179392
76Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.33136907
77Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.32695691
78Decreased activity of mitochondrial respiratory chain (HP:0008972)2.32695691
79Abnormality of nucleobase metabolism (HP:0010932)2.32099414
80Joint hemorrhage (HP:0005261)2.28895320
81Chronic bronchitis (HP:0004469)2.25959271
82Myoglobinuria (HP:0002913)2.24811301
83Fat malabsorption (HP:0002630)2.24777941
84Impaired platelet aggregation (HP:0003540)2.24561160
85Abnormal platelet function (HP:0011869)2.24561160
86Delayed CNS myelination (HP:0002188)2.23288276
87Vomiting (HP:0002013)2.23067567
88Spastic diplegia (HP:0001264)2.22853856
89Hyperuricemia (HP:0002149)2.21544363
90Increased purine levels (HP:0004368)2.21544363
91Methylmalonic acidemia (HP:0002912)2.20837853
92Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.19680562
93Increased serum lactate (HP:0002151)2.17010895
94Exercise-induced muscle cramps (HP:0003710)2.15672761
95Congenital primary aphakia (HP:0007707)2.15187382
96Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.13278701
97Late onset (HP:0003584)2.12567079
98Gait imbalance (HP:0002141)2.09176524
99Respiratory failure (HP:0002878)2.08728562
100Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.07745275
101Increased intramyocellular lipid droplets (HP:0012240)2.06225952
102Abnormality of glutamine family amino acid metabolism (HP:0010902)2.05766666
103Type I transferrin isoform profile (HP:0003642)2.04809456
104Opisthotonus (HP:0002179)2.04135317
105Hepatocellular carcinoma (HP:0001402)2.03895447
106Microvesicular hepatic steatosis (HP:0001414)2.01824099
107Hyperinsulinemic hypoglycemia (HP:0000825)2.01634892
108Enlarged kidneys (HP:0000105)2.01447255
109Progressive external ophthalmoplegia (HP:0000590)2.01324387
110Glycosuria (HP:0003076)1.99906384
111Abnormality of urine glucose concentration (HP:0011016)1.99906384
112Nephrogenic diabetes insipidus (HP:0009806)1.99553452
113Sensorimotor neuropathy (HP:0007141)1.98650100
114Abnormality of the heme biosynthetic pathway (HP:0010472)1.97566831
115Nausea (HP:0002018)1.96630197
116Spontaneous abortion (HP:0005268)1.96460216
117Aplasia/Hypoplasia of the tongue (HP:0010295)1.95664138
118Type 2 muscle fiber atrophy (HP:0003554)1.94638540
119Respiratory difficulties (HP:0002880)1.94365898
120Oligodactyly (hands) (HP:0001180)1.94353276
121Hypochromic microcytic anemia (HP:0004840)1.93187736
122Fair hair (HP:0002286)1.90432058
123Hypoalphalipoproteinemia (HP:0003233)1.89657393
124Sloping forehead (HP:0000340)1.88829400
125Complement deficiency (HP:0004431)1.88175946
126Supernumerary spleens (HP:0009799)1.88123360
127Symptomatic seizures (HP:0011145)1.86720438
128Volvulus (HP:0002580)1.85655607
129Abnormality of the pancreatic islet cells (HP:0006476)1.84826304
130Abnormality of endocrine pancreas physiology (HP:0012093)1.84826304
131Type II lissencephaly (HP:0007260)1.84667297
132Abnormal protein glycosylation (HP:0012346)1.84633467
133Abnormal glycosylation (HP:0012345)1.84633467
134Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.84633467
135Abnormal protein N-linked glycosylation (HP:0012347)1.84633467
136Small intestinal stenosis (HP:0012848)1.84330023
137Duodenal stenosis (HP:0100867)1.84330023
138Reduced antithrombin III activity (HP:0001976)1.83685558
139Rhabdomyolysis (HP:0003201)1.83147985
140Abnormality of glycolysis (HP:0004366)1.81824560
141Increased serum pyruvate (HP:0003542)1.81824560
142Abnormal gallbladder physiology (HP:0012438)1.81032028
143Median cleft lip (HP:0000161)1.80060064
144Nephronophthisis (HP:0000090)1.79787293
145Reticulocytopenia (HP:0001896)1.78347010
146Optic disc pallor (HP:0000543)1.77516403
147CNS demyelination (HP:0007305)1.73673409
148Bile duct proliferation (HP:0001408)1.73400078
149Abnormal biliary tract physiology (HP:0012439)1.73400078
150Gonadotropin excess (HP:0000837)1.72569972
151Leukodystrophy (HP:0002415)1.72467398
152Abnormality of renal resorption (HP:0011038)1.71652625
153Pancreatic islet-cell hyperplasia (HP:0004510)1.66727800
154Nephroblastoma (Wilms tumor) (HP:0002667)1.66257791
155Renal cortical cysts (HP:0000803)1.65048993
156Poor coordination (HP:0002370)1.62997858
157Abnormality of vitamin B metabolism (HP:0004340)1.62143027
158Genital tract atresia (HP:0001827)1.61776565

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.33374037
2TRIM283.73440836
3PBK3.24725669
4MAP3K123.20895852
5FRK3.00752492
6BUB12.80694106
7STK242.65912400
8CAMKK22.33207536
9PDK32.30073293
10PDK42.30073293
11TAOK32.24383106
12ERBB32.16876706
13SCYL22.16609201
14WNK32.15966180
15CCNB12.07699972
16BMPR1B2.06852403
17TTK1.94090781
18BCR1.89282281
19MAP3K131.86949002
20MAP4K21.79248885
21MAP3K41.78777725
22BRSK21.77748620
23MAP2K41.75586872
24PKN21.74257181
25CDK81.68858678
26PLK31.68354088
27ZAK1.68125128
28FLT31.65252291
29TSSK61.61059519
30ERBB41.59934276
31DAPK11.58691607
32SRPK11.53354794
33NUAK11.53215286
34MYLK1.46411209
35PLK11.37662226
36PIK3CA1.35623520
37ACVR1B1.35022945
38PLK41.33961473
39VRK11.26984700
40STK38L1.26814532
41TGFBR21.26511976
42NEK11.22100831
43OBSCN1.21431149
44SIK31.21088743
45CASK1.18890634
46EIF2AK11.18279025
47MAP4K11.17460876
48MAPK131.17391754
49MUSK1.16980572
50GRK71.16642246
51VRK21.13917668
52EPHA41.08242797
53MAP2K71.08191818
54STK161.08190003
55MAP3K61.08007041
56CDK191.07457760
57EIF2AK31.07404668
58DAPK21.02107317
59KIT1.01288061
60PLK20.99153129
61RIPK40.96263556
62MST1R0.95038555
63PTK2B0.93390128
64PINK10.92405296
65MARK30.92138810
66TAOK10.91445824
67MAP3K140.91353345
68PASK0.89565904
69TRIB30.89239296
70ZAP700.88084400
71GRK10.87971888
72MAP3K100.87804908
73RAF10.87502952
74PDK20.85463404
75BRSK10.79867115
76ATR0.79375152
77GRK60.79187768
78MAP3K70.76232325
79EIF2AK20.74991554
80RPS6KB10.74894293
81TAOK20.74019918
82CAMKK10.73982691
83CSNK1G10.73796627
84TXK0.73697122
85CDK30.72687798
86GRK50.72605984
87STK390.71719365
88CSNK1A1L0.70600618
89PHKG10.70593794
90PHKG20.70593794
91TGFBR10.69239338
92MAP3K50.68130826
93CSNK1E0.67816848
94MAPK110.67710556
95TNIK0.66418835
96RPS6KB20.66093759
97TEC0.65917187
98BTK0.65726457
99MKNK10.64614919
100CDK90.64374590
101MKNK20.64067766
102AURKB0.64046788
103PDK10.63365516
104MINK10.62897368
105OXSR10.61849684
106MST40.61834056
107SIK10.61051786
108CDC70.60807132
109CSNK2A20.60557861
110CSNK1G20.60523081
111ILK0.59737575
112ATM0.59256163
113SYK0.57634756
114PNCK0.57549809
115PRKCI0.55548551
116NEK20.54124621
117INSRR0.53584743
118PAK40.53385939
119CHEK10.51826841
120CSF1R0.51641236
121TAF10.51367718
122TYK20.50359130
123PRKACB0.49855999
124JAK20.49831258
125CAMK10.49788361
126MAP2K30.49583282
127ARAF0.48830295
128CSNK1G30.48700517
129CDK40.48636960
130WNK40.48480370
131PRKAA20.47687104
132LIMK10.47640175
133CSNK2A10.46301141
134MAPKAPK30.45811968
135NTRK30.45647009
136BRAF0.45333193
137STK30.45248652
138MAP3K110.44661796
139ERN10.43648450
140NME10.42870356
141WEE10.42142426
142CAMK2D0.41031294
143PRKCG0.40659541
144NEK60.40221719
145EPHA30.39962257
146RPS6KA40.39719108
147AURKA0.39452942
148CAMK2G0.39131322
149BMPR20.39038873
150DYRK30.36212352
151MAP2K60.36140431
152PRKCE0.35554200
153ADRBK20.34895743
154CSNK1A10.33982961
155CAMK2A0.33622948

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.88286554
2Caffeine metabolism_Homo sapiens_hsa002323.74912273
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.44080976
4Primary bile acid biosynthesis_Homo sapiens_hsa001203.18062247
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.69240387
6Mismatch repair_Homo sapiens_hsa034302.64056860
7Sulfur metabolism_Homo sapiens_hsa009202.61813064
8Propanoate metabolism_Homo sapiens_hsa006402.43379348
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.41986062
10DNA replication_Homo sapiens_hsa030302.37853113
11Fatty acid degradation_Homo sapiens_hsa000712.36324817
12Arginine biosynthesis_Homo sapiens_hsa002202.36214866
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.35431618
14Nitrogen metabolism_Homo sapiens_hsa009102.26377210
15Protein export_Homo sapiens_hsa030602.22982284
16Homologous recombination_Homo sapiens_hsa034402.20856252
17Pyruvate metabolism_Homo sapiens_hsa006202.18024806
18Fanconi anemia pathway_Homo sapiens_hsa034602.14437974
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.07420572
20Basal transcription factors_Homo sapiens_hsa030222.07359438
21RNA polymerase_Homo sapiens_hsa030202.02551601
22Butanoate metabolism_Homo sapiens_hsa006502.01118613
23Nucleotide excision repair_Homo sapiens_hsa034201.98220557
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.95052578
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.94448618
26Tryptophan metabolism_Homo sapiens_hsa003801.93583522
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.92326792
28Peroxisome_Homo sapiens_hsa041461.88854346
29Sulfur relay system_Homo sapiens_hsa041221.84472396
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.78666257
31Base excision repair_Homo sapiens_hsa034101.74405952
32Carbon metabolism_Homo sapiens_hsa012001.70762792
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.68491445
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.63367933
35Spliceosome_Homo sapiens_hsa030401.55475344
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.52024839
37Selenocompound metabolism_Homo sapiens_hsa004501.50179127
38Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.49249574
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.49008162
40Drug metabolism - other enzymes_Homo sapiens_hsa009831.48839851
41beta-Alanine metabolism_Homo sapiens_hsa004101.47046465
42Biosynthesis of amino acids_Homo sapiens_hsa012301.38722038
43Phenylalanine metabolism_Homo sapiens_hsa003601.36963535
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.34904813
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.34390128
46Fatty acid metabolism_Homo sapiens_hsa012121.34076363
47Parkinsons disease_Homo sapiens_hsa050121.33912124
48Complement and coagulation cascades_Homo sapiens_hsa046101.32663072
49Oxidative phosphorylation_Homo sapiens_hsa001901.30924154
50Folate biosynthesis_Homo sapiens_hsa007901.28587485
51Pentose and glucuronate interconversions_Homo sapiens_hsa000401.23251716
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.21011424
53Olfactory transduction_Homo sapiens_hsa047401.20505591
54Bile secretion_Homo sapiens_hsa049761.17570395
55Histidine metabolism_Homo sapiens_hsa003401.14778353
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.12583759
57Cell cycle_Homo sapiens_hsa041101.10015789
58Glutathione metabolism_Homo sapiens_hsa004801.09097161
59Tyrosine metabolism_Homo sapiens_hsa003501.06366174
60Starch and sucrose metabolism_Homo sapiens_hsa005001.06083653
61Oocyte meiosis_Homo sapiens_hsa041141.03614836
62Chemical carcinogenesis_Homo sapiens_hsa052041.01581893
63Regulation of autophagy_Homo sapiens_hsa041400.99422341
64PPAR signaling pathway_Homo sapiens_hsa033200.99395634
65Steroid biosynthesis_Homo sapiens_hsa001000.99124060
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.98982023
67Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.95399245
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.93354347
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.93038033
70N-Glycan biosynthesis_Homo sapiens_hsa005100.90580585
71Alzheimers disease_Homo sapiens_hsa050100.89525091
72Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.88349582
73Phototransduction_Homo sapiens_hsa047440.87660773
74Non-homologous end-joining_Homo sapiens_hsa034500.86903128
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84799752
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.83062027
77Glucagon signaling pathway_Homo sapiens_hsa049220.82967471
78Linoleic acid metabolism_Homo sapiens_hsa005910.75148508
79mRNA surveillance pathway_Homo sapiens_hsa030150.69866416
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68126425
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67237305
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66162806
83ABC transporters_Homo sapiens_hsa020100.63493972
84Huntingtons disease_Homo sapiens_hsa050160.62750604
85Fat digestion and absorption_Homo sapiens_hsa049750.60214634
86Metabolic pathways_Homo sapiens_hsa011000.59960498
87Retinol metabolism_Homo sapiens_hsa008300.56203487
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.55603860
89RNA degradation_Homo sapiens_hsa030180.52407044
90Arginine and proline metabolism_Homo sapiens_hsa003300.47709697
91One carbon pool by folate_Homo sapiens_hsa006700.46388083
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46366169
93Cardiac muscle contraction_Homo sapiens_hsa042600.44813957
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43841347
95Glycerolipid metabolism_Homo sapiens_hsa005610.42659774
96Pancreatic secretion_Homo sapiens_hsa049720.41187002
97Vibrio cholerae infection_Homo sapiens_hsa051100.41032004
98Ether lipid metabolism_Homo sapiens_hsa005650.39694652
99Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39510286
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36757066
101Lysine degradation_Homo sapiens_hsa003100.35235799
102Arachidonic acid metabolism_Homo sapiens_hsa005900.34488242
103Fatty acid elongation_Homo sapiens_hsa000620.32913997
104Insulin secretion_Homo sapiens_hsa049110.32048916
105Pyrimidine metabolism_Homo sapiens_hsa002400.32003875
106Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31498978
107Nicotine addiction_Homo sapiens_hsa050330.31104766
108Taste transduction_Homo sapiens_hsa047420.30997756
109Fructose and mannose metabolism_Homo sapiens_hsa000510.30945450
110Circadian rhythm_Homo sapiens_hsa047100.30790796
111Long-term potentiation_Homo sapiens_hsa047200.28884732
112Pentose phosphate pathway_Homo sapiens_hsa000300.28749422
113p53 signaling pathway_Homo sapiens_hsa041150.27193531
114Insulin resistance_Homo sapiens_hsa049310.25651644
115Amphetamine addiction_Homo sapiens_hsa050310.25066544
116Galactose metabolism_Homo sapiens_hsa000520.24105398
117Vitamin B6 metabolism_Homo sapiens_hsa007500.24067855
118Thyroid hormone synthesis_Homo sapiens_hsa049180.23524244
119GABAergic synapse_Homo sapiens_hsa047270.23314150
120Calcium signaling pathway_Homo sapiens_hsa040200.22547590
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.22276144
122Proteasome_Homo sapiens_hsa030500.19899515
123RNA transport_Homo sapiens_hsa030130.19710410
124Collecting duct acid secretion_Homo sapiens_hsa049660.18153889
125Vitamin digestion and absorption_Homo sapiens_hsa049770.17412472
126Aldosterone synthesis and secretion_Homo sapiens_hsa049250.15364596
127Purine metabolism_Homo sapiens_hsa002300.13880281
128Staphylococcus aureus infection_Homo sapiens_hsa051500.12212853
129Ribosome_Homo sapiens_hsa030100.11455987

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