E2F7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: E2F transcription factors, such as E2F7, play an essential role in the regulation of cell cycle progression (Di Stefano et al., 2003 [PubMed 14633988]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1kinetochore organization (GO:0051383)4.85161606
2establishment of integrated proviral latency (GO:0075713)4.74102524
3kinetochore assembly (GO:0051382)4.49684731
4heterochromatin organization (GO:0070828)4.15076738
5telomere maintenance via semi-conservative replication (GO:0032201)4.11457908
6chromosome condensation (GO:0030261)4.08723265
7DNA replication initiation (GO:0006270)4.03619790
8DNA strand elongation involved in DNA replication (GO:0006271)4.02588557
9mitotic recombination (GO:0006312)3.97962957
10DNA strand elongation (GO:0022616)3.95456996
11meiotic chromosome segregation (GO:0045132)3.88481336
12telomere maintenance via recombination (GO:0000722)3.88079816
13CENP-A containing nucleosome assembly (GO:0034080)3.87878873
14DNA replication checkpoint (GO:0000076)3.87654285
15microtubule depolymerization (GO:0007019)3.85595495
16chromatin remodeling at centromere (GO:0031055)3.84444153
17establishment of viral latency (GO:0019043)3.82121514
18negative regulation of DNA-dependent DNA replication (GO:2000104)3.80835915
19DNA unwinding involved in DNA replication (GO:0006268)3.78861837
20regulation of mitotic spindle organization (GO:0060236)3.62009439
21telomere maintenance via telomere lengthening (GO:0010833)3.61260927
22DNA strand renaturation (GO:0000733)3.61237096
23nuclear envelope disassembly (GO:0051081)3.59079021
24membrane disassembly (GO:0030397)3.59079021
25DNA packaging (GO:0006323)3.57358963
26protein K6-linked ubiquitination (GO:0085020)3.54788479
27regulation of centrosome cycle (GO:0046605)3.53224910
28regulation of nuclear cell cycle DNA replication (GO:0033262)3.53187533
29regulation of spindle organization (GO:0090224)3.49100659
30nuclear pore complex assembly (GO:0051292)3.47776253
31nuclear pore organization (GO:0006999)3.45727065
32mismatch repair (GO:0006298)3.45564943
33DNA replication-independent nucleosome organization (GO:0034724)3.44211854
34DNA replication-independent nucleosome assembly (GO:0006336)3.44211854
35protein localization to kinetochore (GO:0034501)3.43696999
36regulation of chromosome segregation (GO:0051983)3.42224631
37regulation of sister chromatid cohesion (GO:0007063)3.41847159
38nucleotide-excision repair, DNA gap filling (GO:0006297)3.40271758
39regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.38229390
40positive regulation of chromosome segregation (GO:0051984)3.37909945
41protein localization to chromosome (GO:0034502)3.36648845
42mitotic sister chromatid segregation (GO:0000070)3.28497986
43protein complex localization (GO:0031503)3.24350190
44mitotic metaphase plate congression (GO:0007080)3.23420938
45* regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.22051960
46DNA conformation change (GO:0071103)3.21141884
47regulation of double-strand break repair via homologous recombination (GO:0010569)3.20756933
48DNA synthesis involved in DNA repair (GO:0000731)3.17786766
49sister chromatid segregation (GO:0000819)3.17590046
50regulation of centrosome duplication (GO:0010824)3.16282794
51double-strand break repair via nonhomologous end joining (GO:0006303)3.12784273
52non-recombinational repair (GO:0000726)3.12784273
53spindle assembly involved in mitosis (GO:0090307)3.12509543
54maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.12329552
55mitotic sister chromatid cohesion (GO:0007064)3.12186425
56cellular protein complex localization (GO:0034629)3.10438437
57DNA double-strand break processing (GO:0000729)3.09925128
58telomere maintenance (GO:0000723)3.07301005
59DNA integration (GO:0015074)3.06200114
60translesion synthesis (GO:0019985)3.04894806
61ventricular cardiac muscle cell development (GO:0055015)3.03568942
62telomere organization (GO:0032200)3.03482812
63DNA ligation (GO:0006266)3.02927349
64centriole assembly (GO:0098534)3.01582691
65histone exchange (GO:0043486)3.00921176
66protein localization to chromosome, centromeric region (GO:0071459)3.00832844
67negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.00359931
68microtubule polymerization or depolymerization (GO:0031109)2.99039214
69* regulation of DNA endoreduplication (GO:0032875)2.98656660
70regulation of mitotic sister chromatid separation (GO:0010965)2.97881461
71centriole replication (GO:0007099)2.96960721
72mitotic chromosome condensation (GO:0007076)2.95901718
73mitotic cell cycle (GO:0000278)2.95452814
74intra-S DNA damage checkpoint (GO:0031573)2.93674115
75nuclear envelope organization (GO:0006998)2.93523113
76paraxial mesoderm development (GO:0048339)2.92776843
77mitotic spindle checkpoint (GO:0071174)2.92683155
78metaphase plate congression (GO:0051310)2.92626731
79positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.91866694
80positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.91866694
81positive regulation of mitotic sister chromatid separation (GO:1901970)2.91866694
82mitotic cytokinesis (GO:0000281)2.91600703
83postreplication repair (GO:0006301)2.91179477
84microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.90922289
85DNA topological change (GO:0006265)2.90678427
86DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.90477841
87pore complex assembly (GO:0046931)2.89030808
88regulation of double-strand break repair (GO:2000779)2.85639027
89negative regulation of mRNA processing (GO:0050686)2.85363032
90regulation of centriole replication (GO:0046599)2.84797325
91pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.82462652
92regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.82167320
93regulation of mitotic spindle checkpoint (GO:1903504)2.82167320
94cell proliferation in forebrain (GO:0021846)2.80299733
95mitotic G2/M transition checkpoint (GO:0044818)2.79193275
96deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.77870097
97DNA geometric change (GO:0032392)2.76509873
98replicative senescence (GO:0090399)2.74500198
99DNA duplex unwinding (GO:0032508)2.73132588
100spindle checkpoint (GO:0031577)2.71881766
101DNA damage response, signal transduction resulting in transcription (GO:0042772)2.71651184
102chromatin assembly or disassembly (GO:0006333)2.71123247
103chromosome segregation (GO:0007059)2.71023753
104ATP-dependent chromatin remodeling (GO:0043044)2.70133064
105telomere maintenance via telomerase (GO:0007004)2.68747065
106regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.68647448
107spindle assembly checkpoint (GO:0071173)2.68643261
108DNA replication-dependent nucleosome organization (GO:0034723)2.68198606
109DNA replication-dependent nucleosome assembly (GO:0006335)2.68198606
110DNA replication (GO:0006260)2.65620554
111negative regulation of chromosome segregation (GO:0051985)2.65505586
112attachment of spindle microtubules to kinetochore (GO:0008608)2.64685642
113negative regulation of mitotic sister chromatid separation (GO:2000816)2.64443222
114negative regulation of mitotic sister chromatid segregation (GO:0033048)2.64443222
115negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.64443222
116negative regulation of sister chromatid segregation (GO:0033046)2.64443222
117dosage compensation (GO:0007549)2.64142577
118regulation of mitotic metaphase/anaphase transition (GO:0030071)2.64139729
119regulation of DNA damage checkpoint (GO:2000001)2.63565285
120establishment of chromosome localization (GO:0051303)2.63407305
121reciprocal meiotic recombination (GO:0007131)2.63244794
122reciprocal DNA recombination (GO:0035825)2.63244794
123recombinational repair (GO:0000725)2.61760511
124replication fork processing (GO:0031297)2.61477609
125response to X-ray (GO:0010165)2.60612628
126regulation of histone H3-K9 methylation (GO:0051570)2.60285403
127* regulation of DNA-dependent DNA replication (GO:0090329)2.57505513
128regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.56455703
129double-strand break repair via homologous recombination (GO:0000724)2.54627242
130negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.54490262
131mitotic nuclear envelope disassembly (GO:0007077)2.54123613
132base-excision repair (GO:0006284)2.53735426
133mitotic spindle assembly checkpoint (GO:0007094)2.52883446
134DNA catabolic process, exonucleolytic (GO:0000738)2.52421618
135regulation of helicase activity (GO:0051095)2.52154493
136regulation of sister chromatid segregation (GO:0033045)2.51999927
137regulation of mitotic sister chromatid segregation (GO:0033047)2.51999927

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.49451381
2E2F4_17652178_ChIP-ChIP_JURKAT_Human5.03717617
3* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.76612003
4TP63_19390658_ChIP-ChIP_HaCaT_Human3.67003009
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.40144393
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.62560077
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.52098246
8* E2F1_21310950_ChIP-Seq_MCF-7_Human2.44951821
9KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.41352967
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.40711966
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.34597927
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.33538670
13* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.19181529
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.15127037
15AR_21909140_ChIP-Seq_LNCAP_Human2.02347064
16E2F7_22180533_ChIP-Seq_HELA_Human12.8033375
17POU5F1_16153702_ChIP-ChIP_HESCs_Human1.92301237
18TP63_17297297_ChIP-ChIP_HaCaT_Human1.90125607
19MYC_19079543_ChIP-ChIP_MESCs_Mouse1.79195665
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.78737207
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.78478208
22SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.73071626
23MYC_19030024_ChIP-ChIP_MESCs_Mouse1.71447973
24HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.69927161
25ELF1_17652178_ChIP-ChIP_JURKAT_Human1.69671615
26ZFX_18555785_ChIP-Seq_MESCs_Mouse1.65416833
27GABP_17652178_ChIP-ChIP_JURKAT_Human1.60987179
28PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.57109149
29YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55336102
30EWS_26573619_Chip-Seq_HEK293_Human1.48122027
31ELK1_19687146_ChIP-ChIP_HELA_Human1.47121375
32* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.46519024
33SOX2_18555785_ChIP-Seq_MESCs_Mouse1.45271474
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.44796267
35NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.44406129
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.42769187
37* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.42535212
38ETS1_20019798_ChIP-Seq_JURKAT_Human1.42031209
39IRF1_19129219_ChIP-ChIP_H3396_Human1.41616109
40CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.40826257
41* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.39903391
42* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.36218157
43NOTCH1_21737748_ChIP-Seq_TLL_Human1.35732479
44PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35580450
45GABP_19822575_ChIP-Seq_HepG2_Human1.34758433
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.29819050
47EST1_17652178_ChIP-ChIP_JURKAT_Human1.29395599
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.28559120
49FUS_26573619_Chip-Seq_HEK293_Human1.28167390
50CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.25475197
51FOXP3_21729870_ChIP-Seq_TREG_Human1.25033559
52ESR1_15608294_ChIP-ChIP_MCF-7_Human1.24032639
53NFE2_27457419_Chip-Seq_LIVER_Mouse1.23265423
54POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.23229847
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20422415
56MYC_18940864_ChIP-ChIP_HL60_Human1.20315385
57KDM5A_27292631_Chip-Seq_BREAST_Human1.19903202
58NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.19891451
59HIF1A_21447827_ChIP-Seq_MCF-7_Human1.19464478
60ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.18726926
61SOX2_16153702_ChIP-ChIP_HESCs_Human1.17554889
62* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.16890094
63SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15052197
64* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15014877
65TTF2_22483619_ChIP-Seq_HELA_Human1.14280365
66NANOG_18555785_ChIP-Seq_MESCs_Mouse1.12778969
67WT1_19549856_ChIP-ChIP_CCG9911_Human1.12462036
68SOX17_20123909_ChIP-Seq_XEN_Mouse1.11749170
69CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10472585
70HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.09605255
71FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.05810978
72BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04482711
73CBX2_27304074_Chip-Seq_ESCs_Mouse1.04222695
74ZNF263_19887448_ChIP-Seq_K562_Human1.03492781
75ZFP57_27257070_Chip-Seq_ESCs_Mouse1.03335598
76TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.02059220
77VDR_23849224_ChIP-Seq_CD4+_Human1.01963983
78KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01876413
79ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.01513314
80KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01144346
81NANOG_21062744_ChIP-ChIP_HESCs_Human1.01080158
82HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.00515778
83CHD1_26751641_Chip-Seq_LNCaP_Human1.00220300
84HOXB4_20404135_ChIP-ChIP_EML_Mouse1.00044765
85PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99983725
86* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99904365
87KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.98970240
88KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.98970240
89KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.98970240
90* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.96907974
91HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96761866
92SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.96117830
93XRN2_22483619_ChIP-Seq_HELA_Human0.95677926
94SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.95212089
95SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.95212089
96EZH2_27294783_Chip-Seq_NPCs_Mouse0.94943017
97FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.94666344
98EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.93131880
99SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.92305907
100NANOG_16153702_ChIP-ChIP_HESCs_Human0.92121045
101GBX2_23144817_ChIP-Seq_PC3_Human0.91132120
102RBPJ_22232070_ChIP-Seq_NCS_Mouse0.89958940
103SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.89848395
104TFEB_21752829_ChIP-Seq_HELA_Human0.89760420
105PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89243298
106CIITA_25753668_ChIP-Seq_RAJI_Human0.88879786
107SUZ12_18555785_Chip-Seq_ESCs_Mouse0.88558526
108* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88342281
109SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.88275102
110TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.86692799
111ATF3_27146783_Chip-Seq_COLON_Human0.86559154
112CLOCK_20551151_ChIP-Seq_293T_Human0.86321272
113DCP1A_22483619_ChIP-Seq_HELA_Human0.86155973
114RNF2_27304074_Chip-Seq_NSC_Mouse0.85584188
115NMYC_18555785_Chip-Seq_ESCs_Mouse0.84773805
116E2F1_18555785_Chip-Seq_ESCs_Mouse0.84547885
117* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.84194378
118IGF1R_20145208_ChIP-Seq_DFB_Human0.83567550
119STAT3_18555785_Chip-Seq_ESCs_Mouse0.83470094
120EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.83144322
121BRD4_25478319_ChIP-Seq_HGPS_Human0.82896122
122TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.82883969
123TCF3_18692474_ChIP-Seq_MEFs_Mouse0.82437956
124NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.82108568
125POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.81779101
126DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.81726295
127EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.81395219
128SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.80973189
129SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.80886717
130THAP11_20581084_ChIP-Seq_MESCs_Mouse0.80780167
131SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.80664952
132MYC_22102868_ChIP-Seq_BL_Human0.80042209
133* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.79882949
134ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.79489289
135GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79400344
136JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.79137915
137RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79119491
138NANOG_18555785_Chip-Seq_ESCs_Mouse0.78541046
139ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.78230319
140TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.77927031
141ZFX_18555785_Chip-Seq_ESCs_Mouse0.77904778
142TCF3_18692474_ChIP-Seq_MESCs_Mouse0.77487291
143OCT4_18555785_Chip-Seq_ESCs_Mouse0.76956470
144RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.76861597
145P53_22387025_ChIP-Seq_ESCs_Mouse0.76723868
146* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.76377274
147POU3F2_20337985_ChIP-ChIP_501MEL_Human0.76073250
148SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.75497596
149P300_18555785_Chip-Seq_ESCs_Mouse0.75427103
150ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.74239634

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.94288237
2MP0003111_abnormal_nucleus_morphology3.45854884
3MP0008057_abnormal_DNA_replication3.40839560
4MP0008058_abnormal_DNA_repair3.34665493
5MP0006292_abnormal_olfactory_placode3.13975559
6MP0000566_synostosis3.13284515
7MP0003693_abnormal_embryo_hatching2.93408276
8MP0010030_abnormal_orbit_morphology2.69414503
9MP0003077_abnormal_cell_cycle2.57855346
10MP0001188_hyperpigmentation2.46878907
11MP0008007_abnormal_cellular_replicative2.44707864
12MP0002877_abnormal_melanocyte_morpholog2.40640190
13MP0003705_abnormal_hypodermis_morpholog2.40233924
14MP0003941_abnormal_skin_development2.31012846
15MP0010352_gastrointestinal_tract_polyps2.16271419
16MP0005623_abnormal_meninges_morphology2.15982395
17MP0008932_abnormal_embryonic_tissue2.04739384
18MP0000537_abnormal_urethra_morphology2.01146220
19MP0004272_abnormal_basement_membrane2.00869594
20MP0008877_abnormal_DNA_methylation1.87019392
21MP0003121_genomic_imprinting1.85938920
22MP0003566_abnormal_cell_adhesion1.85031811
23MP0004957_abnormal_blastocyst_morpholog1.84975958
24MP0003950_abnormal_plasma_membrane1.82835037
25MP0002396_abnormal_hematopoietic_system1.80030100
26MP0002102_abnormal_ear_morphology1.66922441
27MP0003937_abnormal_limbs/digits/tail_de1.65440694
28MP0002938_white_spotting1.63679301
29MP0000383_abnormal_hair_follicle1.60560431
30MP0003136_yellow_coat_color1.58668118
31MP0003890_abnormal_embryonic-extraembry1.57126287
32MP0000049_abnormal_middle_ear1.53077708
33MP0003786_premature_aging1.45029214
34* MP0002080_prenatal_lethality1.44083712
35MP0001293_anophthalmia1.43589950
36MP0005409_darkened_coat_color1.39711822
37MP0005171_absent_coat_pigmentation1.39397985
38MP0000490_abnormal_crypts_of1.38810344
39MP0008789_abnormal_olfactory_epithelium1.38213962
40MP0002234_abnormal_pharynx_morphology1.37686120
41MP0003787_abnormal_imprinting1.36808751
42MP0003123_paternal_imprinting1.36053736
43MP0001299_abnormal_eye_distance/1.34953999
44MP0000350_abnormal_cell_proliferation1.34936415
45MP0009672_abnormal_birth_weight1.33835735
46MP0005257_abnormal_intraocular_pressure1.30352693
47MP0003385_abnormal_body_wall1.26690412
48MP0004808_abnormal_hematopoietic_stem1.21933623
49MP0000569_abnormal_digit_pigmentation1.18907452
50MP0001286_abnormal_eye_development1.18769121
51MP0003755_abnormal_palate_morphology1.18225253
52MP0000762_abnormal_tongue_morphology1.17514405
53MP0005076_abnormal_cell_differentiation1.16454453
54MP0002249_abnormal_larynx_morphology1.13865086
55MP0000432_abnormal_head_morphology1.13220362
56MP0000015_abnormal_ear_pigmentation1.11881945
57MP0002085_abnormal_embryonic_tissue1.11736288
58MP0005380_embryogenesis_phenotype1.11717353
59MP0001672_abnormal_embryogenesis/_devel1.11717353
60MP0009697_abnormal_copulation1.11480669
61MP0003938_abnormal_ear_development1.08263348
62MP0004133_heterotaxia1.07663311
63MP0004197_abnormal_fetal_growth/weight/1.06751356
64MP0002132_abnormal_respiratory_system1.06623936
65MP0000579_abnormal_nail_morphology1.06553931
66MP0010307_abnormal_tumor_latency1.06393868
67MP0003935_abnormal_craniofacial_develop1.05367359
68MP0005197_abnormal_uvea_morphology1.02767405
69MP0003718_maternal_effect1.01953769
70MP0002111_abnormal_tail_morphology1.01359366
71MP0002697_abnormal_eye_size1.00811270
72MP0002116_abnormal_craniofacial_bone0.98789942
73MP0009053_abnormal_anal_canal0.98521514
74MP0004233_abnormal_muscle_weight0.98305174
75MP0005367_renal/urinary_system_phenotyp0.98290254
76MP0000516_abnormal_urinary_system0.98290254
77MP0005501_abnormal_skin_physiology0.96851400
78MP0009278_abnormal_bone_marrow0.96690521
79MP0001346_abnormal_lacrimal_gland0.96467583
80MP0002277_abnormal_respiratory_mucosa0.95920997
81MP0005621_abnormal_cell_physiology0.95165563
82MP0000428_abnormal_craniofacial_morphol0.95133842
83MP0002084_abnormal_developmental_patter0.94990119
84MP0003984_embryonic_growth_retardation0.94930343
85MP0002210_abnormal_sex_determination0.94314139
86MP0000733_abnormal_muscle_development0.94312836
87MP0003942_abnormal_urinary_system0.93907637
88MP0002060_abnormal_skin_morphology0.92739898
89MP0002177_abnormal_outer_ear0.92227452
90MP0002088_abnormal_embryonic_growth/wei0.91857214
91MP0000534_abnormal_ureter_morphology0.91161252
92MP0002098_abnormal_vibrissa_morphology0.90016943
93MP0001730_embryonic_growth_arrest0.89477284
94MP0009250_abnormal_appendicular_skeleto0.88974743
95MP0001119_abnormal_female_reproductive0.88915864
96MP0008438_abnormal_cutaneous_collagen0.88843979
97MP0004381_abnormal_hair_follicle0.88641139
98MP0002932_abnormal_joint_morphology0.88232804
99MP0001849_ear_inflammation0.88070265
100MP0005174_abnormal_tail_pigmentation0.87611665
101MP0005394_taste/olfaction_phenotype0.86166911
102MP0005499_abnormal_olfactory_system0.86166911
103MP0005384_cellular_phenotype0.85388988
104MP0002095_abnormal_skin_pigmentation0.85109768
105MP0000358_abnormal_cell_content/0.84844541
106MP0003091_abnormal_cell_migration0.84604574
107MP0005248_abnormal_Harderian_gland0.84440187
108* MP0000313_abnormal_cell_death0.82912324
109MP0001186_pigmentation_phenotype0.82361340
110MP0003315_abnormal_perineum_morphology0.82195753
111MP0003567_abnormal_fetal_cardiomyocyte0.81467315
112MP0002160_abnormal_reproductive_system0.81230797
113MP0002233_abnormal_nose_morphology0.81011056
114MP0003115_abnormal_respiratory_system0.80902068
115MP0002109_abnormal_limb_morphology0.80825102
116MP0003221_abnormal_cardiomyocyte_apopto0.80616973
117MP0000703_abnormal_thymus_morphology0.78929190
118MP0000647_abnormal_sebaceous_gland0.78851356
119MP0002019_abnormal_tumor_incidence0.78301688
120* MP0001697_abnormal_embryo_size0.78082060
121* MP0002086_abnormal_extraembryonic_tissu0.78076305
122MP0003122_maternal_imprinting0.77868200
123MP0004185_abnormal_adipocyte_glucose0.77331432
124MP0002114_abnormal_axial_skeleton0.76137451
125MP0003943_abnormal_hepatobiliary_system0.75972239
126MP0002075_abnormal_coat/hair_pigmentati0.75817958
127MP0002092_abnormal_eye_morphology0.75416494
128MP0000427_abnormal_hair_cycle0.74436301
129MP0009703_decreased_birth_body0.73543961
130MP0002089_abnormal_postnatal_growth/wei0.72012036
131MP0000627_abnormal_mammary_gland0.71335111
132MP0003861_abnormal_nervous_system0.71224653
133MP0002751_abnormal_autonomic_nervous0.70899407
134MP0000678_abnormal_parathyroid_gland0.69571279
135MP0005389_reproductive_system_phenotype0.69520426
136MP0001340_abnormal_eyelid_morphology0.68761007
137MP0003119_abnormal_digestive_system0.67875060
138MP0002081_perinatal_lethality0.67751579
139MP0001915_intracranial_hemorrhage0.65548900

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)6.05518662
2Chromsome breakage (HP:0040012)5.73728678
3Ectopic kidney (HP:0000086)3.65775541
4Meckel diverticulum (HP:0002245)3.54726591
5Aplasia/Hypoplasia of the uvula (HP:0010293)3.54216333
6Abnormality of chromosome stability (HP:0003220)3.42714241
7Abnormality of the ileum (HP:0001549)3.39929265
8Abnormality of the preputium (HP:0100587)3.39246629
9Duplicated collecting system (HP:0000081)3.37868279
10Abnormality of the renal collecting system (HP:0004742)3.12116519
11Birth length less than 3rd percentile (HP:0003561)2.85314433
12Cortical dysplasia (HP:0002539)2.83740344
13Abnormality of the carotid arteries (HP:0005344)2.72826413
14Abnormal number of incisors (HP:0011064)2.71275870
15Clubbing of toes (HP:0100760)2.70690653
16Duodenal stenosis (HP:0100867)2.66495257
17Small intestinal stenosis (HP:0012848)2.66495257
18Prostate neoplasm (HP:0100787)2.66132506
19Short 4th metacarpal (HP:0010044)2.51709739
20Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.51709739
21Reticulocytopenia (HP:0001896)2.50138084
22Absent radius (HP:0003974)2.49378789
23Abnormality of DNA repair (HP:0003254)2.46515569
24Patellar aplasia (HP:0006443)2.45894799
25Aplasia/Hypoplasia of the sacrum (HP:0008517)2.37786023
26Triphalangeal thumb (HP:0001199)2.37610587
27Squamous cell carcinoma (HP:0002860)2.36530490
28Short thumb (HP:0009778)2.36381918
29Nephroblastoma (Wilms tumor) (HP:0002667)2.36281324
30Aplasia involving forearm bones (HP:0009822)2.34956980
31Absent forearm bone (HP:0003953)2.34956980
32Abnormality of abdominal situs (HP:0011620)2.28590516
33Abdominal situs inversus (HP:0003363)2.28590516
34Abnormality of the incisor (HP:0000676)2.25399722
35Abnormal umbilical cord blood vessels (HP:0011403)2.25346526
36Single umbilical artery (HP:0001195)2.25346526
37Abnormality of the fetal cardiovascular system (HP:0010948)2.25346526
38Abnormality of the duodenum (HP:0002246)2.25012786
39Aplasia/Hypoplasia of the patella (HP:0006498)2.22836781
40Duplication of thumb phalanx (HP:0009942)2.22610793
41Embryonal renal neoplasm (HP:0011794)2.19174744
42Selective tooth agenesis (HP:0001592)2.16686733
43Medulloblastoma (HP:0002885)2.15295038
44Mesomelia (HP:0003027)2.12457606
45Bone marrow hypocellularity (HP:0005528)2.11732577
46Myelodysplasia (HP:0002863)2.07938298
47Abnormality of the umbilical cord (HP:0010881)2.07466739
48Missing ribs (HP:0000921)2.06656140
49Absent thumb (HP:0009777)2.06347162
50Septo-optic dysplasia (HP:0100842)2.06108023
51Abnormality of the nasal septum (HP:0000419)2.05971925
52Overlapping toe (HP:0001845)2.05836457
53Abnormality of the labia minora (HP:0012880)2.04198872
54Short middle phalanx of the 5th finger (HP:0004220)2.03943897
55Microglossia (HP:0000171)2.03306243
56Supernumerary spleens (HP:0009799)1.99031329
5711 pairs of ribs (HP:0000878)1.98755342
58Cafe-au-lait spot (HP:0000957)1.97283792
59Abnormal lung lobation (HP:0002101)1.96949063
60Poikiloderma (HP:0001029)1.96473577
61Tracheoesophageal fistula (HP:0002575)1.96404987
62Ulnar bowing (HP:0003031)1.94955019
63Breast hypoplasia (HP:0003187)1.94250255
64Premature rupture of membranes (HP:0001788)1.93427775
65Sloping forehead (HP:0000340)1.93275806
66Short nail (HP:0001799)1.91137427
67Impulsivity (HP:0100710)1.89488250
68Vertebral arch anomaly (HP:0008438)1.89419475
69Abnormality of incisor morphology (HP:0011063)1.88836281
70Natal tooth (HP:0000695)1.88321705
71Abnormality of the parietal bone (HP:0002696)1.88145837
72Aplasia cutis congenita (HP:0001057)1.87980093
73Abnormality of the columella (HP:0009929)1.87235595
74Volvulus (HP:0002580)1.86274175
75Hyperacusis (HP:0010780)1.83197644
76Abnormality of the distal phalanx of the thumb (HP:0009617)1.82748356
77Long eyelashes (HP:0000527)1.79179222
78Choanal atresia (HP:0000453)1.77745914
79Ankle contracture (HP:0006466)1.77548964
80Entropion (HP:0000621)1.76504250
81Preaxial hand polydactyly (HP:0001177)1.76292719
82Supernumerary ribs (HP:0005815)1.75827986
83Anal stenosis (HP:0002025)1.75231267
84Increased nuchal translucency (HP:0010880)1.73994914
85Rib fusion (HP:0000902)1.72954255
86Hypopigmentation of the fundus (HP:0007894)1.72620687
87Broad distal phalanx of finger (HP:0009836)1.71908243
88Skull defect (HP:0001362)1.71899144
89Supernumerary bones of the axial skeleton (HP:0009144)1.70904846
90Ankyloglossia (HP:0010296)1.70647185
91Abnormality of the calcaneus (HP:0008364)1.68479571
92Intestinal atresia (HP:0011100)1.68317064
93Trigonocephaly (HP:0000243)1.68286409
94Insomnia (HP:0100785)1.67582484
95Upper limb muscle weakness (HP:0003484)1.66515106
96Horseshoe kidney (HP:0000085)1.65810802
97Premature graying of hair (HP:0002216)1.64326671
98Aplasia/Hypoplasia of the breasts (HP:0010311)1.63497579
99Microtia (HP:0008551)1.63272891
100Arteriovenous malformation (HP:0100026)1.63224758
101Aplasia/Hypoplasia of the earlobes (HP:0009906)1.61059260
102Abnormality of the metopic suture (HP:0005556)1.60330887
103Morphological abnormality of the middle ear (HP:0008609)1.60123780
104Hypoplasia of the capital femoral epiphysis (HP:0003090)1.59379800
105Increased number of teeth (HP:0011069)1.59221766
106Aplasia/Hypoplasia of the sternum (HP:0006714)1.56328992
107High pitched voice (HP:0001620)1.55901317
108Abnormality of the phalanges of the hallux (HP:0010057)1.55734537
109Atresia of the external auditory canal (HP:0000413)1.55586785
110Rhabdomyosarcoma (HP:0002859)1.55534687
111Abnormality of chromosome segregation (HP:0002916)1.55294853
112Abnormality of the fingertips (HP:0001211)1.54970321
113Abnormality of oral frenula (HP:0000190)1.54469421
114Hypoplastic pelvis (HP:0008839)1.53980568
115Shallow orbits (HP:0000586)1.53506424
116Deep philtrum (HP:0002002)1.53182093
117Anal atresia (HP:0002023)1.53144881
118Coarctation of aorta (HP:0001680)1.52661087
119Broad face (HP:0000283)1.52345577
120Acute lymphatic leukemia (HP:0006721)1.52274561
121Oligodactyly (HP:0012165)1.51692922
122Abnormal gallbladder physiology (HP:0012438)1.51617425
123Cholecystitis (HP:0001082)1.51617425
124Large earlobe (HP:0009748)1.50506894
125Ependymoma (HP:0002888)1.50292917
126Proximal placement of thumb (HP:0009623)1.49165619
127Capillary hemangiomas (HP:0005306)1.48245533
128Facial hemangioma (HP:0000329)1.48087291
129Deviation of the thumb (HP:0009603)1.47875252
130Renal duplication (HP:0000075)1.47863652
131Abnormality of the intervertebral disk (HP:0005108)1.47719290
132Shoulder girdle muscle weakness (HP:0003547)1.47648679
133High anterior hairline (HP:0009890)1.46762009
134Intestinal fistula (HP:0100819)1.46464467
135Limited elbow extension (HP:0001377)1.46454947
136Lip pit (HP:0100267)1.45685151
137Small epiphyses (HP:0010585)1.45522102
138Midline defect of the nose (HP:0004122)1.45451914
139Embryonal neoplasm (HP:0002898)1.45405249
140Asplenia (HP:0001746)1.45388683
141Adrenal hypoplasia (HP:0000835)1.45234628
142Syringomyelia (HP:0003396)1.44578164
143Spinal cord lesions (HP:0100561)1.44578164
144Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.44467663
145Spinal cord compression (HP:0002176)1.44046360
146Facial cleft (HP:0002006)1.43681190
147Abnormal auditory evoked potentials (HP:0006958)1.43593877
148Glossoptosis (HP:0000162)1.43567872
149Optic nerve hypoplasia (HP:0000609)1.43535650

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.93468788
2MKNK23.40217898
3MKNK13.17711096
4CDK122.93062999
5BRD42.73672818
6SRPK12.69712249
7ZAK2.60882599
8PLK42.50492493
9NEK12.49152213
10WEE12.24529693
11CASK2.10645394
12NEK22.06349576
13EIF2AK22.03004831
14TTK1.98991176
15BUB11.95462817
16ATR1.94310531
17TRIM281.90210525
18VRK11.85192550
19VRK21.82250329
20YES11.79616166
21CDK71.75386640
22SMG11.74208216
23ERBB41.71154399
24PLK11.67871978
25TAF11.59454871
26MAP3K101.58070348
27CCNB11.54980933
28EPHA21.54037108
29MST1R1.51530326
30CHEK21.48348306
31AURKB1.47141539
32STK41.45401651
33TNIK1.43663452
34PLK31.42994663
35PAK41.41695309
36IRAK41.35692325
37CDK31.35090307
38ACVR1B1.30911413
39BRSK21.30089196
40PASK1.28784040
41TLK11.26743969
42STK161.25800722
43CLK11.23429380
44LATS21.22898471
45MET1.21989972
46IRAK31.16407020
47CHEK11.16074625
48STK38L1.16012073
49MAP3K141.13629312
50ATM1.13510554
51ERBB31.11776065
52RPS6KB21.08962562
53STK31.07742993
54PBK1.07410406
55NUAK11.06764853
56CDK41.06451167
57DYRK31.05990971
58TXK1.03995420
59PTK21.02645675
60CDK81.01635415
61RPS6KA40.99742359
62BMPR1B0.95576802
63PNCK0.87457152
64SCYL20.87396088
65CDK90.86564524
66PDGFRA0.84576536
67LATS10.83634978
68BRSK10.83588720
69SIK30.81670451
70TSSK60.81625606
71PLK20.81294060
72NME20.81191981
73PIM10.79545580
74STK100.76325750
75EPHB20.75333047
76CDK20.74136018
77AKT30.73905299
78TTN0.73612727
79CDK10.71202951
80CHUK0.71044378
81PRPF4B0.70768007
82ADRBK20.69851327
83AURKA0.68485162
84RPS6KA50.68299780
85EIF2AK10.68235788
86NLK0.63859027
87MELK0.59959925
88KSR10.58704030
89CDK60.57882445
90CAMK1G0.57815909
91BRAF0.57778911
92TRPM70.57601176
93CDK180.56326950
94MST40.56199102
95TAOK20.54847947
96GRK10.53775768
97AKT20.53054883
98MAP3K80.52658936
99IKBKB0.50954577
100TEC0.50490859
101AKT10.50297038
102CSNK2A10.49928121
103FGFR10.49480501
104CDK150.49381035
105PAK20.48473736
106CDK140.48446224
107MAPK140.48154290
108NEK90.48136712
109CDK11A0.47408279
110DYRK20.46067681
111PRKDC0.45764195
112PIM20.45292806
113MOS0.45137306
114MAPK130.44336973
115IRAK10.43766076
116TGFBR10.43027297
117BTK0.43008021
118PIK3CG0.41029584
119MAPK70.40801271
120LYN0.40338173
121CSNK1D0.37316009
122BCR0.37026947
123ICK0.36741541
124EIF2AK30.36264022
125CSNK2A20.36119075
126GSK3B0.35367511
127PIK3CA0.35027856
128CAMK1D0.33595000
129STK240.33253549
130MAPK10.33162148
131LIMK10.32732487
132PAK10.32242617
133INSRR0.31616709
134MTOR0.29644741
135BMX0.28294442
136NTRK10.27695738
137IRAK20.27287435
138PRKCI0.24473795

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.19196617
2Mismatch repair_Homo sapiens_hsa034303.69998137
3Fanconi anemia pathway_Homo sapiens_hsa034603.58837643
4Homologous recombination_Homo sapiens_hsa034403.49174662
5Base excision repair_Homo sapiens_hsa034102.81504126
6Non-homologous end-joining_Homo sapiens_hsa034502.69366609
7Cell cycle_Homo sapiens_hsa041102.68712906
8Nucleotide excision repair_Homo sapiens_hsa034202.58045511
9One carbon pool by folate_Homo sapiens_hsa006702.46942574
10Spliceosome_Homo sapiens_hsa030402.45394854
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.14069587
12RNA transport_Homo sapiens_hsa030131.83422051
13RNA polymerase_Homo sapiens_hsa030201.77354763
14Basal transcription factors_Homo sapiens_hsa030221.72441624
15p53 signaling pathway_Homo sapiens_hsa041151.71424511
16Pyrimidine metabolism_Homo sapiens_hsa002401.69530853
17RNA degradation_Homo sapiens_hsa030181.57107169
18mRNA surveillance pathway_Homo sapiens_hsa030151.52088298
19Biosynthesis of amino acids_Homo sapiens_hsa012301.51235245
20Basal cell carcinoma_Homo sapiens_hsa052171.50950482
21Vitamin B6 metabolism_Homo sapiens_hsa007501.50007622
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.46824418
23Systemic lupus erythematosus_Homo sapiens_hsa053221.45646118
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.40927762
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.33615262
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.30407561
27Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.29563413
28Herpes simplex infection_Homo sapiens_hsa051681.28867182
29Protein export_Homo sapiens_hsa030601.28007537
30Bladder cancer_Homo sapiens_hsa052191.26609314
31Oocyte meiosis_Homo sapiens_hsa041141.25622986
32Ribosome_Homo sapiens_hsa030101.20692826
33Thyroid cancer_Homo sapiens_hsa052161.20357876
34MicroRNAs in cancer_Homo sapiens_hsa052061.12141854
35Transcriptional misregulation in cancer_Homo sapiens_hsa052021.12101092
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.08830177
37Primary immunodeficiency_Homo sapiens_hsa053401.06803848
38Small cell lung cancer_Homo sapiens_hsa052221.06358748
39NOD-like receptor signaling pathway_Homo sapiens_hsa046210.99640477
40HTLV-I infection_Homo sapiens_hsa051660.99244250
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96436197
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.96290206
43Epstein-Barr virus infection_Homo sapiens_hsa051690.95670408
44Measles_Homo sapiens_hsa051620.95632388
45Hematopoietic cell lineage_Homo sapiens_hsa046400.95346017
46Viral carcinogenesis_Homo sapiens_hsa052030.94526559
47Intestinal immune network for IgA production_Homo sapiens_hsa046720.93816338
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.93768537
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.93701788
50Hedgehog signaling pathway_Homo sapiens_hsa043400.93403963
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.93221223
52Central carbon metabolism in cancer_Homo sapiens_hsa052300.91909037
53Purine metabolism_Homo sapiens_hsa002300.90716298
54Pentose phosphate pathway_Homo sapiens_hsa000300.88144581
55Carbon metabolism_Homo sapiens_hsa012000.88033673
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87924508
57Selenocompound metabolism_Homo sapiens_hsa004500.87215690
58Graft-versus-host disease_Homo sapiens_hsa053320.85632172
59Autoimmune thyroid disease_Homo sapiens_hsa053200.83901466
60Hippo signaling pathway_Homo sapiens_hsa043900.80984305
61Folate biosynthesis_Homo sapiens_hsa007900.80927497
62Allograft rejection_Homo sapiens_hsa053300.79873727
63TGF-beta signaling pathway_Homo sapiens_hsa043500.79863364
64Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.79241858
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.78645659
66Pyruvate metabolism_Homo sapiens_hsa006200.77310331
67Asthma_Homo sapiens_hsa053100.75861450
68Notch signaling pathway_Homo sapiens_hsa043300.74280585
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72266285
70N-Glycan biosynthesis_Homo sapiens_hsa005100.72225657
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72105273
72Proteasome_Homo sapiens_hsa030500.71709490
73Lysine degradation_Homo sapiens_hsa003100.70417662
74Prostate cancer_Homo sapiens_hsa052150.70399098
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70319065
76Wnt signaling pathway_Homo sapiens_hsa043100.69033513
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67891657
78Pathways in cancer_Homo sapiens_hsa052000.66351773
79Apoptosis_Homo sapiens_hsa042100.66186971
80Hepatitis B_Homo sapiens_hsa051610.65793531
81Melanoma_Homo sapiens_hsa052180.65745067
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.64885218
83Focal adhesion_Homo sapiens_hsa045100.64644106
84Adherens junction_Homo sapiens_hsa045200.62631364
85Influenza A_Homo sapiens_hsa051640.61089116
86Colorectal cancer_Homo sapiens_hsa052100.58823324
87Toll-like receptor signaling pathway_Homo sapiens_hsa046200.58333431
88Leishmaniasis_Homo sapiens_hsa051400.56629092
89Malaria_Homo sapiens_hsa051440.55568495
90Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54950911
91Viral myocarditis_Homo sapiens_hsa054160.54853484
92Alcoholism_Homo sapiens_hsa050340.54097128
93Glioma_Homo sapiens_hsa052140.52583836
94Chronic myeloid leukemia_Homo sapiens_hsa052200.52136694
95Fructose and mannose metabolism_Homo sapiens_hsa000510.51686925
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51527838
97TNF signaling pathway_Homo sapiens_hsa046680.51381990
98Arachidonic acid metabolism_Homo sapiens_hsa005900.51139013
99ECM-receptor interaction_Homo sapiens_hsa045120.50459622
100Tight junction_Homo sapiens_hsa045300.50207378
101Jak-STAT signaling pathway_Homo sapiens_hsa046300.49809251
102Non-small cell lung cancer_Homo sapiens_hsa052230.49188100
103PI3K-Akt signaling pathway_Homo sapiens_hsa041510.46080554
104Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45081905
105Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44484969
106Legionellosis_Homo sapiens_hsa051340.43254009
107Glutathione metabolism_Homo sapiens_hsa004800.43229861
108Sulfur relay system_Homo sapiens_hsa041220.42652317
109Pancreatic cancer_Homo sapiens_hsa052120.42013780
110Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40641794
111Antigen processing and presentation_Homo sapiens_hsa046120.39637517
112Acute myeloid leukemia_Homo sapiens_hsa052210.39261859
113Endometrial cancer_Homo sapiens_hsa052130.38163221
114Galactose metabolism_Homo sapiens_hsa000520.37774565
115Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37518559
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36514002
117Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.36117621
118Sphingolipid metabolism_Homo sapiens_hsa006000.35094817
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34525393
120Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33898381
121Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.33232591
122Toxoplasmosis_Homo sapiens_hsa051450.33221487
123Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.33118892
124Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32760511
125Melanogenesis_Homo sapiens_hsa049160.32711637
126Renal cell carcinoma_Homo sapiens_hsa052110.32687864
127FoxO signaling pathway_Homo sapiens_hsa040680.32166428
128Axon guidance_Homo sapiens_hsa043600.31528964
129Shigellosis_Homo sapiens_hsa051310.31404305
130Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31367283
131Steroid biosynthesis_Homo sapiens_hsa001000.30753801
132Phototransduction_Homo sapiens_hsa047440.30658851
133Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.29091358
134Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.28440656
135Proteoglycans in cancer_Homo sapiens_hsa052050.28231961
136Hepatitis C_Homo sapiens_hsa051600.26655563
137Ether lipid metabolism_Homo sapiens_hsa005650.26193903
138Leukocyte transendothelial migration_Homo sapiens_hsa046700.26116654
139AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.22351387
140Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.22342390
141ErbB signaling pathway_Homo sapiens_hsa040120.21970004

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