E2F4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)4.69655744
2DNA unwinding involved in DNA replication (GO:0006268)4.67361341
3protein localization to kinetochore (GO:0034501)4.45966560
4folic acid-containing compound biosynthetic process (GO:0009396)4.44880486
5DNA strand elongation involved in DNA replication (GO:0006271)4.39157272
6DNA replication initiation (GO:0006270)4.37847538
7DNA strand elongation (GO:0022616)4.19412873
8mitotic nuclear envelope disassembly (GO:0007077)4.14550778
9formation of translation preinitiation complex (GO:0001731)4.03553361
10telomere maintenance via semi-conservative replication (GO:0032201)4.03268333
11protein localization to chromosome, centromeric region (GO:0071459)3.95034152
12nuclear pore organization (GO:0006999)3.94939278
13nuclear envelope disassembly (GO:0051081)3.83508624
14membrane disassembly (GO:0030397)3.83508624
15DNA replication checkpoint (GO:0000076)3.76871510
16IMP biosynthetic process (GO:0006188)3.74194835
17nuclear pore complex assembly (GO:0051292)3.74007274
18DNA replication-dependent nucleosome organization (GO:0034723)3.65594781
19DNA replication-dependent nucleosome assembly (GO:0006335)3.65594781
20ribosomal small subunit assembly (GO:0000028)3.64557324
21mitotic sister chromatid segregation (GO:0000070)3.63428011
22telomere maintenance via recombination (GO:0000722)3.56563079
23response to peptidoglycan (GO:0032494)3.54779091
24viral transcription (GO:0019083)3.51962330
25translational termination (GO:0006415)3.44969210
26DNA deamination (GO:0045006)3.44600359
27mitotic metaphase plate congression (GO:0007080)3.41493278
28DNA duplex unwinding (GO:0032508)3.39889773
29positive regulation of gamma-delta T cell activation (GO:0046645)3.38858736
30maturation of SSU-rRNA (GO:0030490)3.37731914
31mitotic chromosome condensation (GO:0007076)3.37668620
32DNA geometric change (GO:0032392)3.37345187
33heterochromatin organization (GO:0070828)3.35629191
34mitotic recombination (GO:0006312)3.34318467
35nucleobase biosynthetic process (GO:0046112)3.33258810
36spliceosomal tri-snRNP complex assembly (GO:0000244)3.32823494
37sister chromatid segregation (GO:0000819)3.31731657
38* regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.31078846
39regulation of translational fidelity (GO:0006450)3.30892046
40negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.30879816
41IMP metabolic process (GO:0046040)3.27606320
42translational elongation (GO:0006414)3.25313929
43telomere maintenance via telomere lengthening (GO:0010833)3.21923874
44translational initiation (GO:0006413)3.21805433
45pre-miRNA processing (GO:0031054)3.21461123
46positive regulation of chromosome segregation (GO:0051984)3.20132875
47mannose metabolic process (GO:0006013)3.16642963
48nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.16152024
49ribosome biogenesis (GO:0042254)3.10557512
50negative regulation of RNA splicing (GO:0033119)3.06441205
51nucleotide-excision repair, DNA gap filling (GO:0006297)3.05603424
523-UTR-mediated mRNA stabilization (GO:0070935)3.05506876
53chromatin assembly (GO:0031497)3.05421578
54negative regulation of histone methylation (GO:0031061)3.04675960
55nuclear envelope organization (GO:0006998)3.04177838
56chromatin assembly or disassembly (GO:0006333)3.01753393
57metaphase plate congression (GO:0051310)3.00918974
58positive regulation by symbiont of host defense response (GO:0052509)2.98628004
59modulation by symbiont of host defense response (GO:0052031)2.98628004
60modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.98628004
61modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.98628004
62positive regulation by organism of defense response of other organism involved in symbiotic interact2.98628004
63modulation by symbiont of host immune response (GO:0052553)2.98628004
64ribosomal small subunit biogenesis (GO:0042274)2.98286044
65modulation by virus of host process (GO:0019054)2.97188920
66regulation of spindle organization (GO:0090224)2.96371964
67regulation of histone H3-K9 methylation (GO:0051570)2.96368319
68ribonucleoprotein complex biogenesis (GO:0022613)2.95789137
69NIK/NF-kappaB signaling (GO:0038061)2.95187065
70regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.93934870
71modulation by symbiont of host cellular process (GO:0044068)2.92713096
72kinetochore organization (GO:0051383)2.92499727
73regulation of posttranscriptional gene silencing (GO:0060147)2.91822964
74regulation of gene silencing by miRNA (GO:0060964)2.91822964
75regulation of gene silencing by RNA (GO:0060966)2.91822964
76regulation of translational termination (GO:0006449)2.90102860
77production of molecular mediator involved in inflammatory response (GO:0002532)2.89698888
78protoporphyrinogen IX metabolic process (GO:0046501)2.88895662
79pinocytosis (GO:0006907)2.88008743
80DNA replication-independent nucleosome assembly (GO:0006336)2.84777467
81DNA replication-independent nucleosome organization (GO:0034724)2.84777467
82negative regulation of mRNA processing (GO:0050686)2.84590475
83establishment of chromosome localization (GO:0051303)2.82501248
84attachment of spindle microtubules to kinetochore (GO:0008608)2.82074234
85positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.81759854
86proline biosynthetic process (GO:0006561)2.81469460
87chromatin remodeling at centromere (GO:0031055)2.81108877
88protein localization to chromosome (GO:0034502)2.80583573
89pore complex assembly (GO:0046931)2.80541638
90dosage compensation (GO:0007549)2.78810607
91ribosomal large subunit biogenesis (GO:0042273)2.76707175
92ribosome assembly (GO:0042255)2.76646591
93CENP-A containing nucleosome assembly (GO:0034080)2.76576472
94SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.76031542
95maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.75328919
96DNA conformation change (GO:0071103)2.75143712
97apoptotic process involved in morphogenesis (GO:0060561)2.73853254
98rRNA processing (GO:0006364)2.73118642
99antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.72226076
100purine nucleobase biosynthetic process (GO:0009113)2.71826218
101folic acid metabolic process (GO:0046655)2.71660804
102pteridine-containing compound biosynthetic process (GO:0042559)2.71246652
103cellular protein complex disassembly (GO:0043624)2.69340516
104pentose-phosphate shunt (GO:0006098)2.69037907
105positive regulation of mitotic sister chromatid separation (GO:1901970)2.68474164
106positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.68474164
107positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.68474164
108somatic hypermutation of immunoglobulin genes (GO:0016446)2.68406169
109somatic diversification of immune receptors via somatic mutation (GO:0002566)2.68406169
110viral life cycle (GO:0019058)2.67220920
111RNA splicing, via transesterification reactions (GO:0000375)2.67172386
112protoporphyrinogen IX biosynthetic process (GO:0006782)2.67103450
113RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.66941370
114mRNA splicing, via spliceosome (GO:0000398)2.66941370
115protein targeting to ER (GO:0045047)2.66378548
116rRNA metabolic process (GO:0016072)2.65756909
117regulation of type I interferon-mediated signaling pathway (GO:0060338)2.64619965
118kinetochore assembly (GO:0051382)2.64380785
119base-excision repair (GO:0006284)2.64369338
120cotranslational protein targeting to membrane (GO:0006613)2.63989673
121translesion synthesis (GO:0019985)2.63659421
122meiotic chromosome segregation (GO:0045132)2.63576912
123response to muramyl dipeptide (GO:0032495)2.62159079
124antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.61920910
125thymic T cell selection (GO:0045061)2.61703709
126UV protection (GO:0009650)2.59582448
127antigen processing and presentation of endogenous antigen (GO:0019883)2.58069436
128histone H3-K36 demethylation (GO:0070544)2.57778268
129positive thymic T cell selection (GO:0045059)2.56171990
130cellular response to interleukin-4 (GO:0071353)2.54368830
131positive regulation of Cdc42 GTPase activity (GO:0043089)2.54265517
132erythrocyte development (GO:0048821)2.51214217
133regulation of histone H3-K27 methylation (GO:0061085)2.50145669
134regulation of mammary gland epithelial cell proliferation (GO:0033599)2.50130348
135mRNA stabilization (GO:0048255)2.49447979
136RNA stabilization (GO:0043489)2.49447979
137regulation of RNA export from nucleus (GO:0046831)2.47943518
138intracellular estrogen receptor signaling pathway (GO:0030520)2.45399633
139regulation of leukocyte degranulation (GO:0043300)2.44805089
140negative regulation of necroptotic process (GO:0060546)2.43602841
141cellular hyperosmotic response (GO:0071474)2.40837165
142regulation of gamma-delta T cell activation (GO:0046643)2.39219556
143embryonic process involved in female pregnancy (GO:0060136)2.38510391
144positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.37604503
145regulation of mast cell degranulation (GO:0043304)2.37393771
146positive regulation of B cell differentiation (GO:0045579)2.37262513
147lipopolysaccharide-mediated signaling pathway (GO:0031663)2.36929125
148erythrocyte maturation (GO:0043249)2.36149778
149negative regulation of phagocytosis (GO:0050765)2.35374811
150antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.34629902
151response to interleukin-4 (GO:0070670)2.34462086
152chromosome condensation (GO:0030261)2.34056623
153Peyers patch development (GO:0048541)2.33188265
154mucosal-associated lymphoid tissue development (GO:0048537)2.33188265
155regulation of gamma-delta T cell differentiation (GO:0045586)2.32192367
156negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.31831332
157negative regulation of interleukin-12 production (GO:0032695)2.30817107
158regulation of myeloid leukocyte mediated immunity (GO:0002886)2.30723452
159negative regulation of cell killing (GO:0031342)2.30572810
160negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.30572810
161negative regulation of viral release from host cell (GO:1902187)2.29986873
162nucleobase-containing small molecule interconversion (GO:0015949)2.29723036
163T cell apoptotic process (GO:0070231)2.29195098
164protein complex localization (GO:0031503)2.28931300
165maternal placenta development (GO:0001893)2.28091797
166regulation of nucleobase-containing compound transport (GO:0032239)2.27991763
167germinal center formation (GO:0002467)2.27292874
168protein export from nucleus (GO:0006611)2.26149249
169NADPH regeneration (GO:0006740)2.25925600
170regulation of superoxide anion generation (GO:0032928)2.25132974
171DNA topological change (GO:0006265)2.22968703
172COPI coating of Golgi vesicle (GO:0048205)2.22848153
173Golgi transport vesicle coating (GO:0048200)2.22848153
174negative regulation of cell size (GO:0045792)2.21430533
175nucleosome disassembly (GO:0006337)2.20885892
176protein-DNA complex disassembly (GO:0032986)2.20885892
177entrainment of circadian clock by photoperiod (GO:0043153)2.20681952
178regulation of ARF GTPase activity (GO:0032312)2.19980172
179neutrophil activation involved in immune response (GO:0002283)2.19755546

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.15976729
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.09976081
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.91425171
4* MYC_18555785_ChIP-Seq_MESCs_Mouse3.53321035
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.14289206
6MYC_22102868_ChIP-Seq_BL_Human2.84013728
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.83288343
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.61397726
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.46446675
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.34243259
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.28314588
12LXR_22292898_ChIP-Seq_THP-1_Human2.11867562
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.05393283
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.01986666
15XRN2_22483619_ChIP-Seq_HELA_Human2.00557609
16EST1_17652178_ChIP-ChIP_JURKAT_Human1.95624158
17* ETS1_20019798_ChIP-Seq_JURKAT_Human1.93547124
18NELFA_20434984_ChIP-Seq_ESCs_Mouse1.92575027
19VDR_21846776_ChIP-Seq_THP-1_Human1.87569392
20E2F1_21310950_ChIP-Seq_MCF-7_Human1.85096231
21KDM2B_26808549_Chip-Seq_SUP-B15_Human1.81871784
22VDR_24763502_ChIP-Seq_THP-1_Human1.77767727
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.76230604
24AR_21909140_ChIP-Seq_LNCAP_Human1.74811624
25* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.74078301
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.69809136
27TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.69064181
28CIITA_25753668_ChIP-Seq_RAJI_Human1.67305604
29KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.63919951
30VDR_23849224_ChIP-Seq_CD4+_Human1.63470702
31NANOG_18555785_ChIP-Seq_MESCs_Mouse1.62163183
32GABP_17652178_ChIP-ChIP_JURKAT_Human1.61548427
33HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.59141678
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.58182609
35SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.57485832
36MYCN_18555785_ChIP-Seq_MESCs_Mouse1.56546667
37RACK7_27058665_Chip-Seq_MCF-7_Human1.55477862
38NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.52818878
39* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.51768125
40* FOXP3_21729870_ChIP-Seq_TREG_Human1.51459021
41GABP_19822575_ChIP-Seq_HepG2_Human1.50224435
42PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.49879047
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.49840296
44STAT3_1855785_ChIP-Seq_MESCs_Mouse1.48609857
45MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.46334238
46NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.45963365
47DCP1A_22483619_ChIP-Seq_HELA_Human1.45923435
48KDM5A_27292631_Chip-Seq_BREAST_Human1.45580717
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.45577641
50THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.45061101
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.42689526
52TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42101569
53ELF1_17652178_ChIP-ChIP_JURKAT_Human1.38926856
54P68_20966046_ChIP-Seq_HELA_Human1.38134230
55* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37648750
56POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.37412581
57TTF2_22483619_ChIP-Seq_HELA_Human1.37253982
58E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.36855572
59TET1_21451524_ChIP-Seq_MESCs_Mouse1.36805301
60THAP11_20581084_ChIP-Seq_MESCs_Mouse1.35240950
61ELF1_20517297_ChIP-Seq_JURKAT_Human1.34736897
62CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33963140
63RARG_19884340_ChIP-ChIP_MEFs_Mouse1.30719343
64KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29999195
65* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.28685207
66STAT4_19710469_ChIP-ChIP_TH1__Mouse1.28406084
67CTCF_27219007_Chip-Seq_ERYTHROID_Human1.27994139
68KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.27660379
69* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25797706
70IRF8_22096565_ChIP-ChIP_GC-B_Human1.25101042
71SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.24964234
72MAF_26560356_Chip-Seq_TH1_Human1.24388738
73UTX_26944678_Chip-Seq_JUKART_Human1.23786419
74TFEB_21752829_ChIP-Seq_HELA_Human1.22062883
75PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21196398
76TCF7_22412390_ChIP-Seq_EML_Mouse1.19256844
77SA1_27219007_Chip-Seq_ERYTHROID_Human1.18337579
78TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.18050820
79PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16515105
80NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.15283570
81CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.14222168
82BCOR_27268052_Chip-Seq_Bcells_Human1.13153503
83* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12594745
84SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.12126756
85* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12058807
86TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10250762
87KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10228158
88ELK3_25401928_ChIP-Seq_HUVEC_Human1.10092291
89TP63_19390658_ChIP-ChIP_HaCaT_Human1.09955212
90* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09945774
91SCL_19346495_ChIP-Seq_HPC-7_Human1.09524413
92ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09396935
93PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09393468
94YY1_21170310_ChIP-Seq_MESCs_Mouse1.09244634
95KDM2B_26808549_Chip-Seq_JURKAT_Human1.08933353
96MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.08919332
97SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.08883984
98KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.08634808
99BCL6_27268052_Chip-Seq_Bcells_Human1.08382027
100TP63_17297297_ChIP-ChIP_HaCaT_Human1.07612916
101E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06682533
102YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06324491
103GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05374723
104SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03668481
105GATA2_22383799_ChIP-Seq_G1ME_Mouse1.03649077
106SMC4_20622854_ChIP-Seq_HELA_Human1.03174468
107HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02816644
108MYB_26560356_Chip-Seq_TH1_Human1.02690738
109* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02662490
110STAT6_21828071_ChIP-Seq_BEAS2B_Human1.02364867
111CTCF_21964334_Chip-Seq_Bcells_Human1.02329584
112MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.02214539
113KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01365872
114* SPI1_23547873_ChIP-Seq_NB4_Human1.00008046
115MAF_26560356_Chip-Seq_TH2_Human0.99918464
116MYB_26560356_Chip-Seq_TH2_Human0.99412686
117NOTCH1_21737748_ChIP-Seq_TLL_Human0.99127386
118* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.99049657
119RUNX1_22412390_ChIP-Seq_EML_Mouse0.98302060
120KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.98089741
121CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.97790071
122* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.97394417
123MYB_21317192_ChIP-Seq_ERMYB_Mouse0.94568711
124NANOG_21062744_ChIP-ChIP_HESCs_Human0.94384261
125KDM2B_26808549_Chip-Seq_DND41_Human0.93799121
126ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.92363178
127BRD4_27068464_Chip-Seq_AML-cells_Mouse0.92140979
128NCOR1_26117541_ChIP-Seq_K562_Human0.91742183
129BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90987054
130ZNF263_19887448_ChIP-Seq_K562_Human0.90937935
131GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90520881
132SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89524996
133STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.89443003
134* ELK1_19687146_ChIP-ChIP_HELA_Human0.89172895
135CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.88784068
136ATF3_27146783_Chip-Seq_COLON_Human0.88668559
137RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.88214351

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.35522637
2MP0003111_abnormal_nucleus_morphology3.94234887
3MP0004957_abnormal_blastocyst_morpholog3.80511487
4MP0010094_abnormal_chromosome_stability3.77125624
5MP0005451_abnormal_body_composition3.48600362
6* MP0003077_abnormal_cell_cycle3.35284890
7MP0008057_abnormal_DNA_replication3.27294917
8MP0010352_gastrointestinal_tract_polyps2.85872678
9MP0002396_abnormal_hematopoietic_system2.77899806
10MP0005058_abnormal_lysosome_morphology2.42545052
11MP0001730_embryonic_growth_arrest2.27425703
12MP0008058_abnormal_DNA_repair2.22327691
13MP0008260_abnormal_autophagy2.18571777
14MP0008007_abnormal_cellular_replicative2.17779459
15MP0000350_abnormal_cell_proliferation2.16975511
16MP0003656_abnormal_erythrocyte_physiolo2.11284930
17MP0010307_abnormal_tumor_latency2.10038242
18MP0005076_abnormal_cell_differentiation1.97468806
19MP0003763_abnormal_thymus_physiology1.95624774
20* MP0000490_abnormal_crypts_of1.93788524
21MP0003172_abnormal_lysosome_physiology1.93664378
22MP0005397_hematopoietic_system_phenotyp1.93302005
23MP0001545_abnormal_hematopoietic_system1.93302005
24MP0008932_abnormal_embryonic_tissue1.81388817
25MP0009333_abnormal_splenocyte_physiolog1.79630801
26MP0004808_abnormal_hematopoietic_stem1.78672274
27* MP0002398_abnormal_bone_marrow1.70439286
28* MP0005380_embryogenesis_phenotype1.69895870
29* MP0001672_abnormal_embryogenesis/_devel1.69895870
30MP0001697_abnormal_embryo_size1.69074721
31MP0000678_abnormal_parathyroid_gland1.68241148
32MP0009840_abnormal_foam_cell1.66591831
33MP0003123_paternal_imprinting1.63431633
34MP0003705_abnormal_hypodermis_morpholog1.60940692
35MP0002419_abnormal_innate_immunity1.60302004
36* MP0003984_embryonic_growth_retardation1.59842955
37MP0002086_abnormal_extraembryonic_tissu1.59467621
38* MP0002019_abnormal_tumor_incidence1.58664169
39MP0000685_abnormal_immune_system1.58034989
40* MP0002080_prenatal_lethality1.57483806
41* MP0002088_abnormal_embryonic_growth/wei1.56034590
42* MP0000703_abnormal_thymus_morphology1.55281692
43MP0009278_abnormal_bone_marrow1.55198875
44* MP0002722_abnormal_immune_system1.53916465
45MP0003191_abnormal_cellular_cholesterol1.52752065
46MP0000689_abnormal_spleen_morphology1.51327175
47MP0000313_abnormal_cell_death1.49052709
48MP0002085_abnormal_embryonic_tissue1.46551663
49MP0002084_abnormal_developmental_patter1.43059086
50MP0003453_abnormal_keratinocyte_physiol1.42606044
51* MP0004197_abnormal_fetal_growth/weight/1.36508980
52MP0003828_pulmonary_edema1.31934598
53MP0009785_altered_susceptibility_to1.27771472
54* MP0002429_abnormal_blood_cell1.27686140
55MP0004147_increased_porphyrin_level1.25370943
56MP0003786_premature_aging1.24794841
57* MP0001849_ear_inflammation1.21435412
58MP0001800_abnormal_humoral_immune1.21313407
59MP0003566_abnormal_cell_adhesion1.21063754
60MP0000858_altered_metastatic_potential1.19391084
61* MP0000716_abnormal_immune_system1.16005411
62MP0003567_abnormal_fetal_cardiomyocyte1.15210677
63MP0006054_spinal_hemorrhage1.15053305
64MP0004233_abnormal_muscle_weight1.12745605
65MP0002653_abnormal_ependyma_morphology1.12642399
66MP0002148_abnormal_hypersensitivity_rea1.11880011
67MP0005023_abnormal_wound_healing1.10253688
68MP0005671_abnormal_response_to1.09414576
69MP0004264_abnormal_extraembryonic_tissu1.08936760
70MP0010234_abnormal_vibrissa_follicle1.08851178
71MP0005666_abnormal_adipose_tissue1.08518501
72MP0002796_impaired_skin_barrier1.06725580
73MP0003806_abnormal_nucleotide_metabolis1.06152627
74* MP0002405_respiratory_system_inflammati1.05503031
75MP0008877_abnormal_DNA_methylation1.04114153
76MP0010030_abnormal_orbit_morphology1.03002836
77MP0010155_abnormal_intestine_physiology1.02142372
78MP0005083_abnormal_biliary_tract0.99185123
79MP0002420_abnormal_adaptive_immunity0.99088004
80MP0001819_abnormal_immune_cell0.97851679
81MP0002452_abnormal_antigen_presenting0.95897544
82MP0001845_abnormal_inflammatory_respons0.94836397
83MP0001835_abnormal_antigen_presentation0.94048667
84MP0004381_abnormal_hair_follicle0.92565488
85MP0001533_abnormal_skeleton_physiology0.91206329
86MP0003436_decreased_susceptibility_to0.90644373
87MP0001915_intracranial_hemorrhage0.90202510
88MP0002998_abnormal_bone_remodeling0.89893489
89* MP0000477_abnormal_intestine_morphology0.89698416
90MP0002723_abnormal_immune_serum0.87869300
91* MP0009931_abnormal_skin_appearance0.87748583
92MP0004510_myositis0.86235018
93MP0003303_peritoneal_inflammation0.86055858
94MP0005621_abnormal_cell_physiology0.86037511
95MP0001293_anophthalmia0.85317636
96MP0001348_abnormal_lacrimal_gland0.85050415
97MP0003091_abnormal_cell_migration0.85009218
98MP0003890_abnormal_embryonic-extraembry0.84821509
99MP0005310_abnormal_salivary_gland0.84347044
100MP0002132_abnormal_respiratory_system0.83251100
101MP0008469_abnormal_protein_level0.82626585
102MP0002166_altered_tumor_susceptibility0.82221743
103MP0003724_increased_susceptibility_to0.81522876
104MP0003300_gastrointestinal_ulcer0.80784973
105MP0000358_abnormal_cell_content/0.80514206
106MP0005384_cellular_phenotype0.80117499
107MP0004858_abnormal_nervous_system0.80066818
108MP0009672_abnormal_birth_weight0.79557764
109MP0000465_gastrointestinal_hemorrhage0.79547609
110MP0001853_heart_inflammation0.79076182
111MP0002877_abnormal_melanocyte_morpholog0.79068888
112MP0005387_immune_system_phenotype0.78669931
113MP0001790_abnormal_immune_system0.78669931
114MP0008770_decreased_survivor_rate0.77716539
115MP0010630_abnormal_cardiac_muscle0.77676844
116MP0005375_adipose_tissue_phenotype0.77665549
117MP0001873_stomach_inflammation0.77303790
118MP0003866_abnormal_defecation0.77286034
119MP0001661_extended_life_span0.75913173
120MP0000747_muscle_weakness0.75551114
121MP0000733_abnormal_muscle_development0.75025639
122MP0005000_abnormal_immune_tolerance0.74782968
123MP0002006_tumorigenesis0.74239334
124MP0009053_abnormal_anal_canal0.73835747
125MP0005464_abnormal_platelet_physiology0.73005672
126MP0004185_abnormal_adipocyte_glucose0.72750089
127MP0003121_genomic_imprinting0.71669797
128MP0003119_abnormal_digestive_system0.71415946
129MP0003448_altered_tumor_morphology0.70546621
130* MP0005025_abnormal_response_to0.70420836
131MP0002925_abnormal_cardiovascular_devel0.70021379
132MP0004947_skin_inflammation0.69448356
133MP0005501_abnormal_skin_physiology0.67186345
134MP0000598_abnormal_liver_morphology0.66737074
135MP0003221_abnormal_cardiomyocyte_apopto0.64104596

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.03931482
2Abnormality of cells of the erythroid lineage (HP:0012130)3.91297780
3Abnormal number of erythroid precursors (HP:0012131)3.81867081
4Cholecystitis (HP:0001082)3.53504554
5Abnormal gallbladder physiology (HP:0012438)3.53504554
6Abnormality of the heme biosynthetic pathway (HP:0010472)3.46669248
7Reticulocytopenia (HP:0001896)3.35252369
8Ependymoma (HP:0002888)3.33359074
9Selective tooth agenesis (HP:0001592)3.23579369
10Basal cell carcinoma (HP:0002671)3.15203780
11Cellulitis (HP:0100658)3.03012145
12Eczematoid dermatitis (HP:0000976)3.02506241
13Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.93218688
14Poikilocytosis (HP:0004447)2.92675310
15Breast hypoplasia (HP:0003187)2.87160445
16Abnormality of reticulocytes (HP:0004312)2.86099276
17Colitis (HP:0002583)2.81098965
18Patellar aplasia (HP:0006443)2.77195663
19Oral leukoplakia (HP:0002745)2.70918104
20Gastrointestinal inflammation (HP:0004386)2.70505060
21Abnormality of the fingertips (HP:0001211)2.64693393
22Centrally nucleated skeletal muscle fibers (HP:0003687)2.64610982
23Medulloblastoma (HP:0002885)2.63203241
24Chromsome breakage (HP:0040012)2.62486107
25Multiple enchondromatosis (HP:0005701)2.60012935
26Polycythemia (HP:0001901)2.59132927
27Reticulocytosis (HP:0001923)2.58450661
28Rhabdomyosarcoma (HP:0002859)2.57681307
29Thrombocytosis (HP:0001894)2.56941362
30Aplasia/Hypoplasia of the patella (HP:0006498)2.55886418
31Myelodysplasia (HP:0002863)2.53894645
32Abnormality of the anterior horn cell (HP:0006802)2.51782207
33Degeneration of anterior horn cells (HP:0002398)2.51782207
34Recurrent abscess formation (HP:0002722)2.51022979
35Hypertensive crisis (HP:0100735)2.48363107
36Obstructive lung disease (HP:0006536)2.46335077
37Chronic obstructive pulmonary disease (HP:0006510)2.46335077
38Colon cancer (HP:0003003)2.45526759
39Abnormality of the thoracic spine (HP:0100711)2.44456073
40Abnormality of macrophages (HP:0004311)2.43506302
41Cholelithiasis (HP:0001081)2.42536252
42Chromosomal breakage induced by crosslinking agents (HP:0003221)2.42386219
43Absent thumb (HP:0009777)2.42219149
44Thoracic kyphosis (HP:0002942)2.41298959
45IgM deficiency (HP:0002850)2.39375005
46Pallor (HP:0000980)2.37045912
47Increased connective tissue (HP:0009025)2.33574794
48Prominent nose (HP:0000448)2.32738111
49Carpal bone hypoplasia (HP:0001498)2.32245322
50Squamous cell carcinoma (HP:0002860)2.28885993
51Abnormality of chromosome stability (HP:0003220)2.26645393
52Aplastic anemia (HP:0001915)2.26001566
53Recurrent fungal infections (HP:0002841)2.25821419
54Trismus (HP:0000211)2.25780346
55Inflammation of the large intestine (HP:0002037)2.25671843
56Ragged-red muscle fibers (HP:0003200)2.23723209
57High pitched voice (HP:0001620)2.23429156
58Recurrent bacterial skin infections (HP:0005406)2.23082311
59Poikiloderma (HP:0001029)2.21861894
60Achilles tendon contracture (HP:0001771)2.21830356
61Progressive muscle weakness (HP:0003323)2.21714998
62Abnormal number of incisors (HP:0011064)2.21334039
63T lymphocytopenia (HP:0005403)2.20665606
64Amaurosis fugax (HP:0100576)2.20297417
65Meckel diverticulum (HP:0002245)2.19974448
66Abnormality of the ileum (HP:0001549)2.18169512
67Rib fusion (HP:0000902)2.17671041
68Agnosia (HP:0010524)2.17606029
69Neoplasm of striated muscle (HP:0009728)2.15592646
70Abnormality of T cells (HP:0002843)2.15569563
71Cafe-au-lait spot (HP:0000957)2.15313041
72Macrocytic anemia (HP:0001972)2.15129436
73Gingivitis (HP:0000230)2.14328378
74Granulocytopenia (HP:0001913)2.13632858
75Abnormality of the preputium (HP:0100587)2.12830619
76Lymphoma (HP:0002665)2.12420100
77Increased IgE level (HP:0003212)2.10663382
78Hypochromic anemia (HP:0001931)2.09361569
79Abnormality of the columella (HP:0009929)2.09202920
80Microvesicular hepatic steatosis (HP:0001414)2.08835334
81Deviation of the thumb (HP:0009603)2.08605314
82Combined immunodeficiency (HP:0005387)2.08344888
83Vertebral compression fractures (HP:0002953)2.07299468
84Proximal placement of thumb (HP:0009623)2.07059351
85Increased IgM level (HP:0003496)2.06880589
86Neoplasm of the pancreas (HP:0002894)2.06770342
87Distal lower limb amyotrophy (HP:0008944)2.05865134
88Increased nuchal translucency (HP:0010880)2.05513027
89Aplasia/Hypoplasia of the uvula (HP:0010293)2.05445539
90Mediastinal lymphadenopathy (HP:0100721)2.05398239
91Spinal cord lesions (HP:0100561)2.05208698
92Syringomyelia (HP:0003396)2.05208698
93Recurrent viral infections (HP:0004429)2.03864631
94Abnormality of the astrocytes (HP:0100707)2.03244349
95Astrocytoma (HP:0009592)2.03244349
96Easy fatigability (HP:0003388)2.03130621
97Abnormality of T cell number (HP:0011839)2.02457309
98Meningitis (HP:0001287)2.01525484
99Ectopic kidney (HP:0000086)2.00872271
100Long palpebral fissure (HP:0000637)2.00268825
101Upper motor neuron abnormality (HP:0002127)2.00197212
102Microretrognathia (HP:0000308)1.98302758
103Prolonged bleeding time (HP:0003010)1.97031755
104Difficulty climbing stairs (HP:0003551)1.95909739
105Rough bone trabeculation (HP:0100670)1.94216281
106Abnormality of T cell physiology (HP:0011840)1.93858875
107Overlapping toe (HP:0001845)1.93617538
108Broad palm (HP:0001169)1.93437884
109Abnormal gallbladder morphology (HP:0012437)1.93240983
110Long eyelashes (HP:0000527)1.92009559
111Fatigue (HP:0012378)1.91520233
112Diaphragmatic weakness (HP:0009113)1.91209818
113Abnormality of iron homeostasis (HP:0011031)1.91184208
114Abnormality of the Achilles tendon (HP:0005109)1.90826378
115Pustule (HP:0200039)1.90631906
116Missing ribs (HP:0000921)1.90527977
117Absent radius (HP:0003974)1.90433254
118Neoplasm of the oral cavity (HP:0100649)1.90088576
119Atresia of the external auditory canal (HP:0000413)1.89739189
120Impulsivity (HP:0100710)1.88995345
121Facial hemangioma (HP:0000329)1.88876763
122Insomnia (HP:0100785)1.87564188
123Microcytic anemia (HP:0001935)1.87139343
124Small intestinal stenosis (HP:0012848)1.86210356
125Duodenal stenosis (HP:0100867)1.86210356
126Tracheoesophageal fistula (HP:0002575)1.86171677
127Abnormality of the gallbladder (HP:0005264)1.85608732
128Skin tags (HP:0010609)1.85289400
129Aplasia/Hypoplasia of the thymus (HP:0010515)1.84893669
130Gastrointestinal dysmotility (HP:0002579)1.83829060
131Disproportionate tall stature (HP:0001519)1.83398296
132Cellular immunodeficiency (HP:0005374)1.83029079
133Hyperacusis (HP:0010780)1.82917782
134Bone marrow hypocellularity (HP:0005528)1.82624818
135Hepatosplenomegaly (HP:0001433)1.81795303
136Gastrointestinal stroma tumor (HP:0100723)1.81003000
137Hypertriglyceridemia (HP:0002155)1.80592513
138Nonimmune hydrops fetalis (HP:0001790)1.80027224
139Progressive external ophthalmoplegia (HP:0000590)1.79949830
140Polygenic inheritance (HP:0010982)1.79225123
141Gastrointestinal infarctions (HP:0005244)1.78487666
142Broad distal phalanx of finger (HP:0009836)1.78212248
143Preauricular skin tag (HP:0000384)1.77564605
144Increased serum ferritin (HP:0003281)1.76413483
145Myopathic facies (HP:0002058)1.75842448
146Slender long bone (HP:0003100)1.75841057
147Abnormal platelet function (HP:0011869)1.75403129
148Impaired platelet aggregation (HP:0003540)1.75403129
149Petechiae (HP:0000967)1.74623644
150Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.73599393
151Abnormality of the calcaneus (HP:0008364)1.73577033
152Epistaxis (HP:0000421)1.73561841
153Exercise-induced myalgia (HP:0003738)1.73136517
154Dysostosis multiplex (HP:0000943)1.73066758
155Increased cerebral lipofuscin (HP:0011813)1.72695543
156Angiofibromas (HP:0010615)1.72604930
157Adenoma sebaceum (HP:0009720)1.72604930
158Deep palmar crease (HP:0006191)1.72358248
159Premature graying of hair (HP:0002216)1.71722496
160Absent forearm bone (HP:0003953)1.71532195
161Aplasia involving forearm bones (HP:0009822)1.71532195
162Slow saccadic eye movements (HP:0000514)1.71055434
163Acute lymphatic leukemia (HP:0006721)1.70528620
164Agammaglobulinemia (HP:0004432)1.69977340
165Thin bony cortex (HP:0002753)1.69502780
166Osteomyelitis (HP:0002754)1.69368413
167Glioma (HP:0009733)1.68669777
168Panhypogammaglobulinemia (HP:0003139)1.67980925
169Increased density of long bones (HP:0006392)1.67875724
170Premature ovarian failure (HP:0008209)1.67657249
171Recurrent gram-negative bacterial infections (HP:0005420)1.67319723
172Myositis (HP:0100614)1.67199721
173Sloping forehead (HP:0000340)1.66506767
174Chronic mucocutaneous candidiasis (HP:0002728)1.66241226
175Recurrent cutaneous fungal infections (HP:0011370)1.66241226
176Autoimmune thrombocytopenia (HP:0001973)1.65815111
177Hemorrhage of the eye (HP:0011885)1.65302257
178Abnormal delayed hypersensitivity skin test (HP:0002963)1.64294144
179Abnormality of skeletal muscle fiber size (HP:0012084)1.60994682
180Personality changes (HP:0000751)1.60663701
181Urticaria (HP:0001025)1.60527018
182Seborrheic dermatitis (HP:0001051)1.58669586
183Broad face (HP:0000283)1.58247245
184IgA deficiency (HP:0002720)1.58207485

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.72043445
2PRPF4B3.71464544
3CDK123.48682297
4EEF2K3.30771101
5IRAK33.30210095
6SMG13.03785268
7MAP3K102.78555785
8NEK22.68469695
9BUB12.63861082
10MAP4K12.58228271
11WEE12.57131094
12EIF2AK12.42531305
13PKN22.24822614
14STK102.19343463
15NME22.10107768
16TRIB32.04433728
17TAOK21.99602609
18RPS6KB21.87885657
19TTK1.78027703
20CDK71.73461960
21MAP3K131.73003826
22CDK41.68000173
23SIK11.61710632
24TESK21.61709851
25MAP3K81.55947840
26RIPK41.49958864
27RPS6KA41.49604504
28NEK11.46437684
29FLT31.44057918
30GRK61.41029747
31MAP3K11.38657218
32TSSK61.36782101
33SCYL21.36645815
34ATR1.36308673
35PLK11.36030569
36ERN11.34879581
37IRAK41.34874572
38AURKB1.33203468
39PASK1.29676219
40PIM11.29343730
41ARAF1.28007204
42STK41.26938010
43DYRK31.25686460
44LRRK21.23348861
45VRK21.22987444
46MAP2K31.22054529
47KSR21.18788645
48BRSK21.18424717
49BRD41.17084452
50TLK11.16800068
51JAK31.16688156
52ZAP701.13585824
53FGFR41.13351675
54CHEK11.13255380
55ACVR1B1.12366361
56PAK41.10702363
57MAP3K141.10441010
58CHEK21.10374260
59MAP3K111.08069316
60ALK1.07155344
61KDR0.98938256
62CDK60.96312278
63EPHA20.95954748
64SRPK10.94596863
65TGFBR10.93196945
66MAPKAPK30.90093184
67IRAK20.88979070
68PDPK10.88418918
69AURKA0.88185139
70BRSK10.87912876
71TAOK10.87757330
72TBK10.87548586
73PLK40.86904333
74VRK10.85726858
75MTOR0.84811172
76CDK20.82161058
77BTK0.78165754
78ATM0.77425871
79BRAF0.75528479
80ICK0.74577782
81RPS6KC10.73973242
82RPS6KL10.73973242
83TYK20.73210017
84PIM20.72044262
85FES0.69494992
86SIK20.68631282
87MARK20.68212867
88MAP3K90.67441360
89MST1R0.66998556
90MAPK110.65148317
91RAF10.64120074
92EIF2AK30.63548202
93PDK10.63355849
94CDC42BPA0.61869451
95PRKD20.60721234
96MKNK10.60120648
97BMX0.59994358
98MELK0.59807131
99FGR0.59667276
100STK30.59171515
101MOS0.58280473
102PAK10.57786674
103RPS6KA20.57161535
104NME10.56239993
105CDK80.56207420
106TTN0.54257865
107MAP2K20.54208319
108TESK10.53683284
109CSF1R0.53139336
110AKT20.51569417
111EPHB10.50764714
112CLK10.50670586
113CDK90.50176936
114CHUK0.49909741
115RPS6KA60.49637222
116PTK60.49481601
117CSNK2A20.48972879
118PLK30.48815901
119MAPK120.48704962
120RIPK10.48190657
121CDK10.46976838
122HCK0.46714070
123BLK0.45925081
124ILK0.45889064
125SYK0.41740373
126TXK0.41513101
127MAPKAPK20.40890593
128RPS6KA50.40631595
129LATS20.40267245
130CSNK2A10.39248504
131PAK20.39227886
132HIPK20.38594745
133TNK20.38471242
134RPS6KA10.37823849
135MAP3K30.37411239
136LCK0.36916163
137IKBKB0.35954236
138MKNK20.35264051
139CSK0.35186194
140ITK0.35144206
141MARK30.34895252

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.76932787
2Mismatch repair_Homo sapiens_hsa034303.84064049
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.01623086
4Base excision repair_Homo sapiens_hsa034102.96607665
5Spliceosome_Homo sapiens_hsa030402.94512199
6RNA transport_Homo sapiens_hsa030132.85486953
7Ribosome_Homo sapiens_hsa030102.76722971
8One carbon pool by folate_Homo sapiens_hsa006702.73304714
9* Cell cycle_Homo sapiens_hsa041102.59024585
10Nucleotide excision repair_Homo sapiens_hsa034202.50619324
11Homologous recombination_Homo sapiens_hsa034402.42077244
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.27525398
13Other glycan degradation_Homo sapiens_hsa005112.18344480
14RNA polymerase_Homo sapiens_hsa030202.12467396
15Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.95150346
16Pyrimidine metabolism_Homo sapiens_hsa002401.86300186
17mRNA surveillance pathway_Homo sapiens_hsa030151.78659236
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.78346699
19p53 signaling pathway_Homo sapiens_hsa041151.70415458
20RNA degradation_Homo sapiens_hsa030181.69439331
21Non-homologous end-joining_Homo sapiens_hsa034501.67235437
22Fanconi anemia pathway_Homo sapiens_hsa034601.65523824
23Proteasome_Homo sapiens_hsa030501.61131678
24Primary immunodeficiency_Homo sapiens_hsa053401.48181839
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.40227956
26Antigen processing and presentation_Homo sapiens_hsa046121.33768840
27Herpes simplex infection_Homo sapiens_hsa051681.32770997
28Viral carcinogenesis_Homo sapiens_hsa052031.30211267
29Systemic lupus erythematosus_Homo sapiens_hsa053221.25120121
30Basal transcription factors_Homo sapiens_hsa030221.24196659
31Glycosaminoglycan degradation_Homo sapiens_hsa005311.15303939
32Epstein-Barr virus infection_Homo sapiens_hsa051691.15170132
33Tuberculosis_Homo sapiens_hsa051521.11142103
34Malaria_Homo sapiens_hsa051441.10910269
35Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.10235808
36HTLV-I infection_Homo sapiens_hsa051661.08242499
37Sulfur relay system_Homo sapiens_hsa041221.07623383
38Thyroid cancer_Homo sapiens_hsa052161.05192015
39Cyanoamino acid metabolism_Homo sapiens_hsa004601.04909000
40Chronic myeloid leukemia_Homo sapiens_hsa052201.04782816
41TNF signaling pathway_Homo sapiens_hsa046681.02539760
42Allograft rejection_Homo sapiens_hsa053301.01824336
43Neurotrophin signaling pathway_Homo sapiens_hsa047221.00063545
44Hepatitis C_Homo sapiens_hsa051600.98902732
45Pentose phosphate pathway_Homo sapiens_hsa000300.97580769
46Biosynthesis of amino acids_Homo sapiens_hsa012300.96542330
47Acute myeloid leukemia_Homo sapiens_hsa052210.95159768
48Selenocompound metabolism_Homo sapiens_hsa004500.94724699
49Small cell lung cancer_Homo sapiens_hsa052220.93566164
50Measles_Homo sapiens_hsa051620.90704567
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90007050
52Autoimmune thyroid disease_Homo sapiens_hsa053200.87696615
53Apoptosis_Homo sapiens_hsa042100.87085917
54Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87004947
55Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.85217403
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84897214
57MicroRNAs in cancer_Homo sapiens_hsa052060.84488755
58Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.84036017
59Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82781509
60NF-kappa B signaling pathway_Homo sapiens_hsa040640.82761110
61Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82397734
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.81087627
63Prion diseases_Homo sapiens_hsa050200.79993448
64Hepatitis B_Homo sapiens_hsa051610.77783448
65Glioma_Homo sapiens_hsa052140.76937418
66Purine metabolism_Homo sapiens_hsa002300.76538878
67Bladder cancer_Homo sapiens_hsa052190.76505891
68Renal cell carcinoma_Homo sapiens_hsa052110.76229926
69Notch signaling pathway_Homo sapiens_hsa043300.76125148
70Hematopoietic cell lineage_Homo sapiens_hsa046400.73899133
71Insulin signaling pathway_Homo sapiens_hsa049100.73864157
72Legionellosis_Homo sapiens_hsa051340.73344795
73B cell receptor signaling pathway_Homo sapiens_hsa046620.71737128
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.70482366
75Graft-versus-host disease_Homo sapiens_hsa053320.69400368
76Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65683503
77Colorectal cancer_Homo sapiens_hsa052100.64575646
78mTOR signaling pathway_Homo sapiens_hsa041500.62722668
79Oocyte meiosis_Homo sapiens_hsa041140.62686204
80Shigellosis_Homo sapiens_hsa051310.62606262
81T cell receptor signaling pathway_Homo sapiens_hsa046600.62180761
82Prolactin signaling pathway_Homo sapiens_hsa049170.62058087
83Non-small cell lung cancer_Homo sapiens_hsa052230.60521088
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.59944125
85ErbB signaling pathway_Homo sapiens_hsa040120.59518344
86Asthma_Homo sapiens_hsa053100.59218161
87Folate biosynthesis_Homo sapiens_hsa007900.59017070
88Viral myocarditis_Homo sapiens_hsa054160.58452867
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57674730
90Staphylococcus aureus infection_Homo sapiens_hsa051500.57640842
91N-Glycan biosynthesis_Homo sapiens_hsa005100.57422201
92Leishmaniasis_Homo sapiens_hsa051400.57364940
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.55692191
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55605002
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54667259
96Pancreatic cancer_Homo sapiens_hsa052120.54501344
97Lysosome_Homo sapiens_hsa041420.54111196
98Influenza A_Homo sapiens_hsa051640.52631901
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.52485888
100Chemokine signaling pathway_Homo sapiens_hsa040620.51591851
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51122915
102Endocytosis_Homo sapiens_hsa041440.50983068
103Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50956355
104Intestinal immune network for IgA production_Homo sapiens_hsa046720.50820721
105Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49793860
106Lysine degradation_Homo sapiens_hsa003100.49650985
1072-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48537657
108Jak-STAT signaling pathway_Homo sapiens_hsa046300.46883514
109HIF-1 signaling pathway_Homo sapiens_hsa040660.46769345
110Vitamin B6 metabolism_Homo sapiens_hsa007500.45650934
111RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.44517657
112Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43707604
113Adherens junction_Homo sapiens_hsa045200.43439584
114Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43040823
115Carbon metabolism_Homo sapiens_hsa012000.42694985
116Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.40565458
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.39588318
118Hippo signaling pathway_Homo sapiens_hsa043900.38922122
119Toxoplasmosis_Homo sapiens_hsa051450.37821835
120Prostate cancer_Homo sapiens_hsa052150.35384858
121Pathways in cancer_Homo sapiens_hsa052000.34667866
122Fructose and mannose metabolism_Homo sapiens_hsa000510.34178460
123VEGF signaling pathway_Homo sapiens_hsa043700.34155626
124Endometrial cancer_Homo sapiens_hsa052130.32338945
125Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.32099305
126Alcoholism_Homo sapiens_hsa050340.32099286
127Galactose metabolism_Homo sapiens_hsa000520.31693056
128NOD-like receptor signaling pathway_Homo sapiens_hsa046210.31137902
129Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30596901
130Osteoclast differentiation_Homo sapiens_hsa043800.27913188
131Proteoglycans in cancer_Homo sapiens_hsa052050.27615483

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