E2F3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a small family of transcription factors that function through binding of DP interaction partner proteins. The encoded protein recognizes a specific sequence motif in DNA and interacts directly with the retinoblastoma protein (pRB) to regulate the expression of genes involved in the cell cycle. Altered copy number and activity of this gene have been observed in a number of human cancers. There are pseudogenes for this gene on chromosomes 2 and 17. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)6.08090308
2pre-miRNA processing (GO:0031054)5.00245388
3nuclear pore complex assembly (GO:0051292)4.85871421
4nuclear pore organization (GO:0006999)4.65640985
5protein localization to kinetochore (GO:0034501)4.45504774
6heterochromatin organization (GO:0070828)4.37693516
7negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.17580590
8DNA replication-dependent nucleosome assembly (GO:0006335)4.14896590
9DNA replication-dependent nucleosome organization (GO:0034723)4.14896590
10mitotic sister chromatid cohesion (GO:0007064)3.98461757
11negative regulation of mRNA processing (GO:0050686)3.97021874
12DNA replication initiation (GO:0006270)3.92193316
13DNA duplex unwinding (GO:0032508)3.89723655
14DNA geometric change (GO:0032392)3.88780289
15pore complex assembly (GO:0046931)3.77327440
16negative regulation of RNA splicing (GO:0033119)3.76091126
17sister chromatid segregation (GO:0000819)3.75350432
18mitotic nuclear envelope disassembly (GO:0007077)3.75191635
19IMP biosynthetic process (GO:0006188)3.72217608
20DNA strand elongation involved in DNA replication (GO:0006271)3.70355965
21cellular protein complex localization (GO:0034629)3.69910753
22maturation of SSU-rRNA (GO:0030490)3.58156982
23mitotic sister chromatid segregation (GO:0000070)3.57194979
24protein localization to chromosome, centromeric region (GO:0071459)3.55563240
25nuclear envelope disassembly (GO:0051081)3.55430315
26membrane disassembly (GO:0030397)3.55430315
27regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.55208510
28negative regulation of mRNA metabolic process (GO:1903312)3.53870357
29establishment of integrated proviral latency (GO:0075713)3.50932873
30mitotic chromosome condensation (GO:0007076)3.48322959
31DNA strand elongation (GO:0022616)3.46959602
32protein complex localization (GO:0031503)3.44737455
33peptidyl-arginine omega-N-methylation (GO:0035247)3.43847009
34mitotic G2/M transition checkpoint (GO:0044818)3.43501697
35ribosomal small subunit biogenesis (GO:0042274)3.39307377
36chromatin assembly (GO:0031497)3.36476063
37regulation of sister chromatid cohesion (GO:0007063)3.34383802
38regulation of translational fidelity (GO:0006450)3.33227269
39glucocorticoid receptor signaling pathway (GO:0042921)3.30261434
40chromatin assembly or disassembly (GO:0006333)3.28013242
41regulation of RNA export from nucleus (GO:0046831)3.27799965
42purine nucleobase biosynthetic process (GO:0009113)3.27611179
43paraxial mesoderm development (GO:0048339)3.24629968
44regulation of DNA endoreduplication (GO:0032875)3.23712082
45negative regulation of histone methylation (GO:0031061)3.22711518
46negative regulation of DNA repair (GO:0045738)3.21581876
47telomere maintenance via semi-conservative replication (GO:0032201)3.21301728
48mRNA stabilization (GO:0048255)3.17405877
49RNA stabilization (GO:0043489)3.17405877
50IMP metabolic process (GO:0046040)3.16349028
51translesion synthesis (GO:0019985)3.14581282
52kinetochore organization (GO:0051383)3.12528136
53mitotic G1 DNA damage checkpoint (GO:0031571)3.11006136
54peptidyl-arginine N-methylation (GO:0035246)3.10046373
55peptidyl-arginine methylation (GO:0018216)3.10046373
56nucleobase biosynthetic process (GO:0046112)3.08936851
57regulation of hippo signaling (GO:0035330)3.07933679
58DNA replication-independent nucleosome organization (GO:0034724)3.07246839
59DNA replication-independent nucleosome assembly (GO:0006336)3.07246839
60establishment of apical/basal cell polarity (GO:0035089)3.07246368
61regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.06556044
62DNA synthesis involved in DNA repair (GO:0000731)3.04527768
63positive regulation of chromosome segregation (GO:0051984)3.03933932
64mitotic recombination (GO:0006312)3.02172361
65peptidyl-lysine dimethylation (GO:0018027)3.01793541
66spliceosomal tri-snRNP complex assembly (GO:0000244)3.00352602
67negative regulation of chromosome segregation (GO:0051985)2.99846502
68regulation of nucleobase-containing compound transport (GO:0032239)2.96765794
69DNA conformation change (GO:0071103)2.95852850
70metaphase plate congression (GO:0051310)2.95438519
71chromatin remodeling at centromere (GO:0031055)2.95252202
72chromosome segregation (GO:0007059)2.91285650
73regulation of gene silencing by RNA (GO:0060966)2.90468449
74regulation of posttranscriptional gene silencing (GO:0060147)2.90468449
75regulation of gene silencing by miRNA (GO:0060964)2.90468449
76negative regulation of mitotic sister chromatid segregation (GO:0033048)2.90435681
77negative regulation of mitotic sister chromatid separation (GO:2000816)2.90435681
78negative regulation of sister chromatid segregation (GO:0033046)2.90435681
79negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.90435681
80negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.90435681
81regulation of spindle organization (GO:0090224)2.90074064
82mitotic G2 DNA damage checkpoint (GO:0007095)2.90037930
83regulation of stem cell maintenance (GO:2000036)2.89207336
84folic acid-containing compound biosynthetic process (GO:0009396)2.87445745
85nucleotide-excision repair, DNA gap filling (GO:0006297)2.86059235
86CENP-A containing nucleosome assembly (GO:0034080)2.84736029
87chromosome condensation (GO:0030261)2.83933322
88telomere maintenance via recombination (GO:0000722)2.83395515
89mRNA splice site selection (GO:0006376)2.83115411
90regulation of mitotic spindle organization (GO:0060236)2.82184502
91positive regulation of gamma-delta T cell activation (GO:0046645)2.81328586
92positive regulation of histone H3-K4 methylation (GO:0051571)2.81230641
93regulation of chromosome segregation (GO:0051983)2.81131071
94negative regulation of erythrocyte differentiation (GO:0045647)2.80192561
95regulation of mitotic metaphase/anaphase transition (GO:0030071)2.79087741
96regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.79087741
97establishment of chromosome localization (GO:0051303)2.78690872
98nuclear envelope organization (GO:0006998)2.76246389
99polarized epithelial cell differentiation (GO:0030859)2.76004647
100hippo signaling (GO:0035329)2.75323718
101spindle checkpoint (GO:0031577)2.74809198
102G1 DNA damage checkpoint (GO:0044783)2.74387019
103mitotic G1/S transition checkpoint (GO:0044819)2.73123323
104DNA replication checkpoint (GO:0000076)2.72953055
105ATP-dependent chromatin remodeling (GO:0043044)2.72641321
106positive regulation of SMAD protein import into nucleus (GO:0060391)2.72556205
107DNA topological change (GO:0006265)2.72075533
108ribosome assembly (GO:0042255)2.71836762
109NLS-bearing protein import into nucleus (GO:0006607)2.71455274
110regulation of histone H3-K9 methylation (GO:0051570)2.71025422
111mitotic spindle checkpoint (GO:0071174)2.70797395
1123-UTR-mediated mRNA stabilization (GO:0070935)2.69686523
113double-strand break repair via nonhomologous end joining (GO:0006303)2.69526026
114non-recombinational repair (GO:0000726)2.69526026
115regulation of sister chromatid segregation (GO:0033045)2.69127951
116regulation of mitotic sister chromatid separation (GO:0010965)2.69127951
117regulation of mitotic sister chromatid segregation (GO:0033047)2.69127951
118regulation of mRNA stability (GO:0043488)2.68723176
119ribonucleoprotein complex biogenesis (GO:0022613)2.68664443
120ribosomal large subunit biogenesis (GO:0042273)2.66773604
121histone arginine methylation (GO:0034969)2.66147218
122mitotic spindle assembly checkpoint (GO:0007094)2.65869597
123ribosomal small subunit assembly (GO:0000028)2.65756793
124establishment or maintenance of monopolar cell polarity (GO:0061339)2.64471360
125establishment of monopolar cell polarity (GO:0061162)2.64471360
126regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.63780317
127histone H2A monoubiquitination (GO:0035518)2.62995066
128regulation of translational termination (GO:0006449)2.62218466
129spindle assembly checkpoint (GO:0071173)2.61346753
130mRNA transport (GO:0051028)2.60485524
131regulation of double-strand break repair (GO:2000779)2.60156437
132positive regulation of mitotic sister chromatid separation (GO:1901970)2.59969164
133positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.59969164
134positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.59969164
135mRNA splicing, via spliceosome (GO:0000398)2.59591777
136RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.59591777
137histone exchange (GO:0043486)2.59421353
138DNA packaging (GO:0006323)2.58917226
139RNA splicing, via transesterification reactions (GO:0000375)2.58288725
140mitotic metaphase plate congression (GO:0007080)2.57970984
141alternative mRNA splicing, via spliceosome (GO:0000380)2.56375889
142corticosteroid receptor signaling pathway (GO:0031958)2.56040690
143formation of translation preinitiation complex (GO:0001731)2.55900942

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.76104852
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.23256162
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.62927800
4* MYC_18555785_ChIP-Seq_MESCs_Mouse3.59571243
5* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.03574054
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.88745116
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.85419927
8* MYC_22102868_ChIP-Seq_BL_Human2.58042580
9* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.57562406
10AR_21909140_ChIP-Seq_LNCAP_Human2.46646787
11ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.40848261
12* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.36092807
13* E2F1_21310950_ChIP-Seq_MCF-7_Human2.30227260
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.23744457
15TP63_19390658_ChIP-ChIP_HaCaT_Human2.15929785
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.03780102
17* E2F7_22180533_ChIP-Seq_HELA_Human11.2320730
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.87937174
19SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.86094303
20POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.83589094
21RBPJ_22232070_ChIP-Seq_NCS_Mouse1.82739524
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.78603471
23SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.78348636
24KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.78109652
25KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.78109652
26KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.78109652
27* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.77875443
28* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.75195429
29XRN2_22483619_ChIP-Seq_HELA_Human1.74972251
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.71576851
31ESR1_15608294_ChIP-ChIP_MCF-7_Human1.71124556
32* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.70963579
33HOXB4_20404135_ChIP-ChIP_EML_Mouse1.68422829
34HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.68383775
35VDR_21846776_ChIP-Seq_THP-1_Human1.65673248
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.65564381
37HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.58980295
38DCP1A_22483619_ChIP-Seq_HELA_Human1.58383904
39ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.57418291
40FOXP3_21729870_ChIP-Seq_TREG_Human1.55136822
41* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.54778161
42CIITA_25753668_ChIP-Seq_RAJI_Human1.51825771
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.51743663
44TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.50020212
45ETS1_20019798_ChIP-Seq_JURKAT_Human1.49327789
46ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.49040303
47MYB_21317192_ChIP-Seq_ERMYB_Mouse1.49030516
48SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.44701382
49SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.43795767
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.43447674
51ERG_20887958_ChIP-Seq_HPC-7_Mouse1.42845966
52GABP_17652178_ChIP-ChIP_JURKAT_Human1.42597390
53TCF3_18692474_ChIP-Seq_MEFs_Mouse1.42157791
54HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.41385313
55KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.40294022
56JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.38379727
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.38242418
58* SPI1_23547873_ChIP-Seq_NB4_Human1.37423412
59WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.35886962
60YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35807929
61ELF1_17652178_ChIP-ChIP_JURKAT_Human1.33011701
62* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32631386
63ELK1_19687146_ChIP-ChIP_HELA_Human1.32503366
64* TTF2_22483619_ChIP-Seq_HELA_Human1.31169995
65GATA1_22025678_ChIP-Seq_K562_Human1.30748358
66CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.30475525
67SOX2_18555785_ChIP-Seq_MESCs_Mouse1.29924894
68* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.29489216
69RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25962914
70MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.25578667
71ZFX_18555785_ChIP-Seq_MESCs_Mouse1.25151706
72DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24817761
73* TCF7_22412390_ChIP-Seq_EML_Mouse1.24593240
74GABP_19822575_ChIP-Seq_HepG2_Human1.24485872
75NANOG_21062744_ChIP-ChIP_HESCs_Human1.24431645
76* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.23911598
77TFEB_21752829_ChIP-Seq_HELA_Human1.22659484
78GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.22051830
79* KDM2B_26808549_Chip-Seq_DND41_Human1.21822147
80CREB1_15753290_ChIP-ChIP_HEK293T_Human1.20213968
81MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.20159257
82VDR_23849224_ChIP-Seq_CD4+_Human1.20086610
83SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.19497264
84EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.18311697
85SCL_19346495_ChIP-Seq_HPC-7_Human1.18138689
86STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17349543
87* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.16748059
88* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.16676075
89ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.15367644
90* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.14550564
91NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.14530746
92* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.13772846
93KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.13242048
94KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13041810
95NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.12574179
96TCF3_18692474_ChIP-Seq_MESCs_Mouse1.11581065
97CHD1_26751641_Chip-Seq_LNCaP_Human1.08664519
98* NCOR1_26117541_ChIP-Seq_K562_Human1.08225082
99THAP11_20581084_ChIP-Seq_MESCs_Mouse1.08121022
100NANOG_18555785_ChIP-Seq_MESCs_Mouse1.07881364
101SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.07374018
102STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.06866353
103FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.06647159
104MAF_26560356_Chip-Seq_TH1_Human1.06529315
105PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06137448
106POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05493108
107KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04566709
108KDM5A_27292631_Chip-Seq_BREAST_Human1.00554321
109VDR_24763502_ChIP-Seq_THP-1_Human1.00519249
110* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98886285
111E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98828054
112HIF1A_21447827_ChIP-Seq_MCF-7_Human0.98734499
113CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.98404237
114* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.98359037
115ELK3_25401928_ChIP-Seq_HUVEC_Human0.97733028
116MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.97661956
117NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.97568633
118SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.97479430
119KDM2B_26808549_Chip-Seq_JURKAT_Human0.96837568
120PKCTHETA_26484144_Chip-Seq_BREAST_Human0.96611915
121WT1_19549856_ChIP-ChIP_CCG9911_Human0.96457351
122* MYB_26560356_Chip-Seq_TH2_Human0.96342764
123FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.95916844
124CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95498648
125* SOX2_16153702_ChIP-ChIP_HESCs_Human0.95195265
126* NANOG_16153702_ChIP-ChIP_HESCs_Human0.94968969
127* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.94751973
128STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94257438
129KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94157447
130* MYB_26560356_Chip-Seq_TH1_Human0.93988877
131* UTX_26944678_Chip-Seq_JUKART_Human0.93643360
132TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.93025001
133POU5F1_16518401_ChIP-PET_MESCs_Mouse0.92609548
134NOTCH1_21737748_ChIP-Seq_TLL_Human0.92462612
135TP53_22127205_ChIP-Seq_IMR90_Human0.91652408
136EST1_17652178_ChIP-ChIP_JURKAT_Human0.90520014
137P300_27058665_Chip-Seq_ZR-75-30cells_Human0.89415236
138PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87860941
139CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.85316068
140RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.84804767
141GATA1_22383799_ChIP-Seq_G1ME_Mouse0.84516675
142NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.84225299
143* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.83697985

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.39374793
2MP0010094_abnormal_chromosome_stability3.16270514
3MP0003123_paternal_imprinting3.07653153
4MP0010352_gastrointestinal_tract_polyps3.05942925
5MP0003111_abnormal_nucleus_morphology2.89191122
6MP0010030_abnormal_orbit_morphology2.74100293
7MP0004957_abnormal_blastocyst_morpholog2.73699400
8MP0003121_genomic_imprinting2.61943907
9* MP0003077_abnormal_cell_cycle2.49684367
10MP0000537_abnormal_urethra_morphology2.26931529
11MP0005076_abnormal_cell_differentiation2.23995823
12MP0003122_maternal_imprinting2.18273374
13* MP0004197_abnormal_fetal_growth/weight/2.15074241
14MP0001730_embryonic_growth_arrest2.09059862
15* MP0000350_abnormal_cell_proliferation2.07395067
16MP0002877_abnormal_melanocyte_morpholog2.04059585
17MP0008932_abnormal_embryonic_tissue2.02713806
18MP0009053_abnormal_anal_canal2.00890595
19MP0003705_abnormal_hypodermis_morpholog1.99829300
20MP0010307_abnormal_tumor_latency1.96606559
21MP0003693_abnormal_embryo_hatching1.96399691
22MP0002084_abnormal_developmental_patter1.96322643
23MP0005623_abnormal_meninges_morphology1.95024691
24MP0002085_abnormal_embryonic_tissue1.91076806
25MP0003303_peritoneal_inflammation1.84599552
26MP0001697_abnormal_embryo_size1.84381923
27MP0001672_abnormal_embryogenesis/_devel1.83427108
28MP0005380_embryogenesis_phenotype1.83427108
29MP0000569_abnormal_digit_pigmentation1.83163780
30MP0002396_abnormal_hematopoietic_system1.79942187
31MP0008058_abnormal_DNA_repair1.77236690
32MP0003984_embryonic_growth_retardation1.73350143
33MP0002088_abnormal_embryonic_growth/wei1.71244784
34MP0001293_anophthalmia1.70422734
35MP0003890_abnormal_embryonic-extraembry1.64317936
36MP0002086_abnormal_extraembryonic_tissu1.64183563
37MP0003567_abnormal_fetal_cardiomyocyte1.61073443
38MP0006292_abnormal_olfactory_placode1.60428058
39MP0005451_abnormal_body_composition1.59846725
40MP0008007_abnormal_cellular_replicative1.58845616
41MP0003942_abnormal_urinary_system1.58511889
42MP0004185_abnormal_adipocyte_glucose1.53566327
43MP0000733_abnormal_muscle_development1.50754792
44MP0003385_abnormal_body_wall1.50408699
45MP0000703_abnormal_thymus_morphology1.46078893
46* MP0002080_prenatal_lethality1.45294097
47MP0004808_abnormal_hematopoietic_stem1.44683946
48MP0003119_abnormal_digestive_system1.42812479
49MP0000428_abnormal_craniofacial_morphol1.40202319
50MP0003937_abnormal_limbs/digits/tail_de1.39176199
51MP0002398_abnormal_bone_marrow1.36885397
52MP0004233_abnormal_muscle_weight1.33631711
53MP0003115_abnormal_respiratory_system1.31537122
54MP0004133_heterotaxia1.31107225
55MP0003806_abnormal_nucleotide_metabolis1.30334206
56MP0003861_abnormal_nervous_system1.25784156
57MP0000534_abnormal_ureter_morphology1.25276064
58MP0002111_abnormal_tail_morphology1.24865292
59MP0003935_abnormal_craniofacial_develop1.22158029
60MP0009703_decreased_birth_body1.21608590
61MP0002089_abnormal_postnatal_growth/wei1.21567057
62MP0002938_white_spotting1.19694532
63MP0009697_abnormal_copulation1.19579624
64MP0002932_abnormal_joint_morphology1.17733562
65MP0002925_abnormal_cardiovascular_devel1.17100379
66MP0009250_abnormal_appendicular_skeleto1.16958809
67MP0003941_abnormal_skin_development1.16781002
68MP0002722_abnormal_immune_system1.16562298
69MP0009333_abnormal_splenocyte_physiolog1.16250313
70MP0004272_abnormal_basement_membrane1.16233691
71MP0002697_abnormal_eye_size1.16116442
72MP0003283_abnormal_digestive_organ1.15391761
73MP0002653_abnormal_ependyma_morphology1.15176645
74MP0002009_preneoplasia1.14579063
75MP0001915_intracranial_hemorrhage1.14078813
76MP0005464_abnormal_platelet_physiology1.13953839
77MP0000432_abnormal_head_morphology1.12796475
78MP0003763_abnormal_thymus_physiology1.12697815
79MP0001545_abnormal_hematopoietic_system1.12530005
80MP0005397_hematopoietic_system_phenotyp1.12530005
81MP0002092_abnormal_eye_morphology1.12354834
82MP0003221_abnormal_cardiomyocyte_apopto1.10987839
83MP0003787_abnormal_imprinting1.10807783
84MP0008260_abnormal_autophagy1.10286222
85MP0000049_abnormal_middle_ear1.09479041
86MP0002249_abnormal_larynx_morphology1.08484082
87MP0005023_abnormal_wound_healing1.08200413
88MP0003656_abnormal_erythrocyte_physiolo1.06382975
89MP0003566_abnormal_cell_adhesion1.04507462
90MP0000689_abnormal_spleen_morphology1.03674894
91MP0003436_decreased_susceptibility_to1.02653157
92MP0009672_abnormal_birth_weight1.01479664
93MP0002429_abnormal_blood_cell1.01307832
94MP0000313_abnormal_cell_death1.00540906
95MP0002114_abnormal_axial_skeleton0.99482507
96MP0010630_abnormal_cardiac_muscle0.99217833
97MP0009278_abnormal_bone_marrow0.99214113
98* MP0005621_abnormal_cell_physiology0.96922123
99MP0003755_abnormal_palate_morphology0.96407079
100MP0002116_abnormal_craniofacial_bone0.95522228
101MP0000858_altered_metastatic_potential0.94661693
102MP0003786_premature_aging0.94510567
103MP0001835_abnormal_antigen_presentation0.94278050
104MP0002132_abnormal_respiratory_system0.93450588
105MP0000266_abnormal_heart_morphology0.92441466
106MP0008770_decreased_survivor_rate0.92191209
107MP0008877_abnormal_DNA_methylation0.92163940
108MP0000716_abnormal_immune_system0.88420616
109MP0003091_abnormal_cell_migration0.88201573
110MP0008438_abnormal_cutaneous_collagen0.88101827
111MP0002081_perinatal_lethality0.88083652
112* MP0001286_abnormal_eye_development0.84999927
113MP0001853_heart_inflammation0.84466940
114MP0002751_abnormal_autonomic_nervous0.84301890
115MP0002419_abnormal_innate_immunity0.83311486
116* MP0005384_cellular_phenotype0.83280041
117MP0001849_ear_inflammation0.81862865
118MP0003315_abnormal_perineum_morphology0.81296045
119MP0001819_abnormal_immune_cell0.80361396
120MP0002420_abnormal_adaptive_immunity0.79963316
121MP0002282_abnormal_trachea_morphology0.79921057
122MP0001299_abnormal_eye_distance/0.79738882
123MP0006054_spinal_hemorrhage0.79727706
124MP0005367_renal/urinary_system_phenotyp0.79113044
125MP0000516_abnormal_urinary_system0.79113044
126MP0003943_abnormal_hepatobiliary_system0.78807718
127MP0002109_abnormal_limb_morphology0.78253719
128MP0005248_abnormal_Harderian_gland0.77621771
129MP0000462_abnormal_digestive_system0.76952004
130MP0005187_abnormal_penis_morphology0.76876859
131MP0002452_abnormal_antigen_presenting0.76602219
132MP0000678_abnormal_parathyroid_gland0.75916481
133MP0000015_abnormal_ear_pigmentation0.75668186
134MP0003938_abnormal_ear_development0.75667364
135MP0003448_altered_tumor_morphology0.75663281
136MP0006035_abnormal_mitochondrial_morpho0.75474728
137MP0003300_gastrointestinal_ulcer0.73255551
138MP0003172_abnormal_lysosome_physiology0.72769538
139MP0002019_abnormal_tumor_incidence0.72301384
140MP0002723_abnormal_immune_serum0.71924460
141MP0004381_abnormal_hair_follicle0.71205746
142MP0001800_abnormal_humoral_immune0.70756623
143MP0003453_abnormal_keratinocyte_physiol0.69282092
144MP0009384_cardiac_valve_regurgitation0.68424880
145MP0003718_maternal_effect0.68086494
146MP0000358_abnormal_cell_content/0.68063055
147MP0001614_abnormal_blood_vessel0.67387546
148MP0000490_abnormal_crypts_of0.66644663
149* MP0002405_respiratory_system_inflammati0.65632356

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)4.00196563
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.00196563
3Birth length less than 3rd percentile (HP:0003561)3.68102841
4Ependymoma (HP:0002888)3.40977051
5Renal duplication (HP:0000075)3.06641770
6Myelodysplasia (HP:0002863)3.06624301
7Colon cancer (HP:0003003)3.04253528
8Abnormality of the astrocytes (HP:0100707)3.00190635
9Astrocytoma (HP:0009592)3.00190635
10Abnormality of the 4th metacarpal (HP:0010012)2.96984256
11Abnormal number of incisors (HP:0011064)2.89328997
12Medulloblastoma (HP:0002885)2.84752135
13Abnormality of the labia minora (HP:0012880)2.80308735
14Deep philtrum (HP:0002002)2.79206258
15Increased nuchal translucency (HP:0010880)2.74042679
16Selective tooth agenesis (HP:0001592)2.69205767
17Ankyloglossia (HP:0010296)2.68670149
18Shallow orbits (HP:0000586)2.61515822
19Acute myeloid leukemia (HP:0004808)2.61389844
20Volvulus (HP:0002580)2.57698524
21Glioma (HP:0009733)2.57694625
22Abnormality of the preputium (HP:0100587)2.52735787
23Aplasia/Hypoplasia of the sacrum (HP:0008517)2.52035902
24Hyperacusis (HP:0010780)2.51602272
25Pallor (HP:0000980)2.51312249
26Abnormality of the fingertips (HP:0001211)2.49434764
27Neoplasm of striated muscle (HP:0009728)2.46093758
28Large earlobe (HP:0009748)2.45238168
29Short middle phalanx of the 5th finger (HP:0004220)2.40109405
30Skin tags (HP:0010609)2.38738223
31Acute lymphatic leukemia (HP:0006721)2.37787344
32Progressive muscle weakness (HP:0003323)2.36602157
33Supernumerary ribs (HP:0005815)2.36278612
34Thrombocytosis (HP:0001894)2.36076329
35Neoplasm of the oral cavity (HP:0100649)2.33208543
36Progressive external ophthalmoplegia (HP:0000590)2.32911874
37Rhabdomyosarcoma (HP:0002859)2.32468144
38Chromsome breakage (HP:0040012)2.32073240
39Multiple enchondromatosis (HP:0005701)2.28644524
40Pseudobulbar signs (HP:0002200)2.28202805
41Proximal placement of thumb (HP:0009623)2.27993541
42Chromosomal breakage induced by crosslinking agents (HP:0003221)2.27961895
43Asplenia (HP:0001746)2.26791284
44Deviation of the thumb (HP:0009603)2.25790543
45Supernumerary bones of the axial skeleton (HP:0009144)2.24508199
46Recurrent viral infections (HP:0004429)2.20827285
47Preauricular skin tag (HP:0000384)2.18751721
48Aplasia/Hypoplasia of the spleen (HP:0010451)2.18377823
49Abnormality of oral frenula (HP:0000190)2.16491896
50Homocystinuria (HP:0002156)2.16057471
51Abnormality of homocysteine metabolism (HP:0010919)2.16057471
52Atresia of the external auditory canal (HP:0000413)2.15358621
53Abnormality of the columella (HP:0009929)2.15261169
54Trigonocephaly (HP:0000243)2.14936632
55High anterior hairline (HP:0009890)2.14514340
56Missing ribs (HP:0000921)2.12128904
57Fibroma (HP:0010614)2.10469531
58Broad thumb (HP:0011304)2.10035860
59Truncus arteriosus (HP:0001660)2.09950799
60Fibrous tissue neoplasm (HP:0012316)2.09557240
61Recurrent bacterial skin infections (HP:0005406)2.09510476
62Bowel diverticulosis (HP:0005222)2.07884204
63Protrusio acetabuli (HP:0003179)2.03975451
64Rib fusion (HP:0000902)2.03684916
65Increased density of long bones (HP:0006392)2.03139272
66Recurrent abscess formation (HP:0002722)2.00969788
67Basal cell carcinoma (HP:0002671)2.00152031
68Skull defect (HP:0001362)1.99899610
69Aplasia/Hypoplasia of the thymus (HP:0010515)1.99356143
70Pointed chin (HP:0000307)1.99180030
71Squamous cell carcinoma (HP:0002860)1.98040403
72Small intestinal stenosis (HP:0012848)1.97136935
73Duodenal stenosis (HP:0100867)1.97136935
74Diastasis recti (HP:0001540)1.96456935
7511 pairs of ribs (HP:0000878)1.96060423
76Viral hepatitis (HP:0006562)1.95673606
77Capillary hemangiomas (HP:0005306)1.95595362
78Metaphyseal cupping (HP:0003021)1.94172546
79Spinal cord lesions (HP:0100561)1.93349403
80Syringomyelia (HP:0003396)1.93349403
81Abnormality of cochlea (HP:0000375)1.92626455
82Cellular immunodeficiency (HP:0005374)1.92508206
83Macrocytic anemia (HP:0001972)1.91424391
84Annular pancreas (HP:0001734)1.90954530
85Breast hypoplasia (HP:0003187)1.90772725
86Adenoma sebaceum (HP:0009720)1.90015607
87Angiofibromas (HP:0010615)1.90015607
88Overriding aorta (HP:0002623)1.89927558
89Ectopic kidney (HP:0000086)1.89583350
90Intestinal fistula (HP:0100819)1.89272810
91Uterine leiomyosarcoma (HP:0002891)1.88916240
92Leiomyosarcoma (HP:0100243)1.88916240
93Esophageal atresia (HP:0002032)1.88695990
94Genu recurvatum (HP:0002816)1.86491480
95Abnormality of cells of the erythroid lineage (HP:0012130)1.84214512
96Abnormality of the thymus (HP:0000777)1.82763465
97Aplastic anemia (HP:0001915)1.81742276
98Amaurosis fugax (HP:0100576)1.81290569
99Renovascular hypertension (HP:0100817)1.81002102
100Long eyelashes (HP:0000527)1.80790513
101Abnormality of the phalanges of the hallux (HP:0010057)1.80544571
102Facial hemangioma (HP:0000329)1.80194795
103Obsessive-compulsive behavior (HP:0000722)1.79562838
104High pitched voice (HP:0001620)1.79506208
105Reticulocytopenia (HP:0001896)1.78596450
106Broad palm (HP:0001169)1.78182321
107Respiratory difficulties (HP:0002880)1.78181718
108Mild short stature (HP:0003502)1.77574132
109Short phalanx of the thumb (HP:0009660)1.77292951
110Asymmetry of the thorax (HP:0001555)1.76823431
111Deviation of the hallux (HP:0010051)1.76534884
112Urethral obstruction (HP:0000796)1.75513755
113Spastic diplegia (HP:0001264)1.75225997
114Choanal atresia (HP:0000453)1.75003191
115Elfin facies (HP:0004428)1.74495092
116Abnormality of the distal phalanx of the thumb (HP:0009617)1.73900339
117Bone marrow hypocellularity (HP:0005528)1.73830906
118Bilateral microphthalmos (HP:0007633)1.73134493
119Nephroblastoma (Wilms tumor) (HP:0002667)1.73004642
120Flared metaphyses (HP:0003015)1.72728797
121Cortical dysplasia (HP:0002539)1.72490866
122Hepatoblastoma (HP:0002884)1.72485574
123Rectal fistula (HP:0100590)1.71940172
124Rectovaginal fistula (HP:0000143)1.71940172
125Abnormality of the diencephalon (HP:0010662)1.71481133
126Abnormality of the duodenum (HP:0002246)1.71204028
127Agnosia (HP:0010524)1.70925644
128Prominent nose (HP:0000448)1.70866806
129Biliary tract neoplasm (HP:0100574)1.70800615
130Meckel diverticulum (HP:0002245)1.70785254
131Disproportionate tall stature (HP:0001519)1.70352848
132Subacute progressive viral hepatitis (HP:0006572)1.70171435
133Abnormal foot bone ossification (HP:0010675)1.70156890
134Abnormality of abdominal situs (HP:0011620)1.69990556
135Abdominal situs inversus (HP:0003363)1.69990556
136Abnormality of chromosome stability (HP:0003220)1.69939216
137Duplication of thumb phalanx (HP:0009942)1.69710149
138Insomnia (HP:0100785)1.69572873
139Cerebral aneurysm (HP:0004944)1.69189726
140Hallux valgus (HP:0001822)1.68856783
141Gastrointestinal carcinoma (HP:0002672)1.67520724
142Malignant gastrointestinal tract tumors (HP:0006749)1.67520724
143Poikiloderma (HP:0001029)1.67153136
144Aplasia/Hypoplasia of the breasts (HP:0010311)1.66951440
145T lymphocytopenia (HP:0005403)1.66210731
146Cafe-au-lait spot (HP:0000957)1.65889524
147Microvesicular hepatic steatosis (HP:0001414)1.65246480
148Septate vagina (HP:0001153)1.64972198
149Aplasia/Hypoplasia of the sternum (HP:0006714)1.64870113
150Aqueductal stenosis (HP:0002410)1.64794754
151Abnormality of the ileum (HP:0001549)1.64547234
152Aplasia/Hypoplasia of the uvula (HP:0010293)1.63645286
153Cleft eyelid (HP:0000625)1.63502628
154Breast aplasia (HP:0100783)1.63288198
155Absent radius (HP:0003974)1.62859597
156Sacral dimple (HP:0000960)1.62643932
157Abnormality of the peritoneum (HP:0002585)1.62165885
158Abnormality of the carotid arteries (HP:0005344)1.61926899
159Broad phalanges of the hand (HP:0009768)1.61738426
160Benign neoplasm of the central nervous system (HP:0100835)1.61108010
161Pancytopenia (HP:0001876)1.61082809
162Transitional cell carcinoma of the bladder (HP:0006740)1.60858696
163Sandal gap (HP:0001852)1.58833863
164Embryonal renal neoplasm (HP:0011794)1.58350819
165Lymphangioma (HP:0100764)1.57748435
166Tracheoesophageal fistula (HP:0002575)1.56017234
167Midline defect of the nose (HP:0004122)1.55971338
168Abnormal lung lobation (HP:0002101)1.55793923
169Arnold-Chiari malformation (HP:0002308)1.55363330

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.33004376
2CDK123.62199801
3MAP3K103.34109334
4PKN22.64710715
5WEE12.44895797
6MKNK12.38768242
7EEF2K2.20099868
8SMG12.14615270
9PRPF4B2.14406163
10NEK22.04025715
11ALK2.02821082
12NEK12.02440913
13ICK1.97137991
14IRAK31.89500917
15KSR11.80021649
16NME21.74132253
17TRIB31.73617498
18CDK71.66889117
19PLK41.66235900
20MKNK21.66008352
21SCYL21.65980684
22PASK1.60307857
23BRD41.56576833
24MAP2K31.54265447
25TTK1.51975487
26LATS21.50990538
27RPS6KB21.50187407
28TAF11.50117306
29CDK61.49865758
30RIPK41.49086404
31IRAK41.41225651
32MTOR1.39955190
33ATR1.39900214
34* CHEK11.34374758
35PDGFRA1.33362801
36CDK41.33079437
37PAK41.31550535
38MAP3K81.31069283
39PBK1.30859776
40DMPK1.29964591
41SRPK11.29800038
42TTN1.28958792
43MAP3K141.27714875
44PLK11.25537034
45TGFBR11.24037341
46STK101.24009954
47PLK31.21025183
48BUB11.19031200
49NTRK11.18318552
50TSSK61.18086776
51SIK21.15477755
52IRAK21.12745850
53TESK21.12389560
54PAK21.11832766
55VRK21.11804607
56NUAK11.10518720
57SIK31.09456215
58DYRK31.07726285
59YES11.04417028
60STK41.03408387
61CDK21.01747001
62LRRK21.01675339
63ERBB21.00223993
64TYRO30.99375457
65AURKB0.98008889
66EIF2AK10.97718008
67MINK10.95918497
68FGFR10.93230334
69PNCK0.93046887
70ATM0.92387920
71FLT30.91675070
72BMX0.91672809
73FGFR20.90364657
74DDR20.89112847
75EIF2AK20.86356379
76* CHEK20.85591447
77TLK10.84977372
78CDK10.84327239
79EPHB20.84036015
80PTK60.82845716
81CLK10.81848159
82BRSK20.81771178
83TYK20.81589566
84PIM10.81523921
85SIK10.81058888
86RPS6KA40.80523708
87STK160.80275766
88IRAK10.79959634
89TAOK20.79141109
90TEC0.78989710
91CSNK1E0.78839649
92MARK30.78457007
93FGR0.77971104
94MAP3K130.76747972
95UHMK10.76080569
96TRIM280.71953431
97TAOK10.71621524
98CAMK1G0.71262471
99STK240.69388149
100LATS10.67887396
101BRSK10.66177877
102CDK180.64376246
103CDK140.63533469
104CSK0.62842526
105BTK0.62591313
106AURKA0.61231567
107INSRR0.59786642
108FRK0.59348848
109MAPK100.57021391
110CDK150.56878529
111CSNK1D0.56870343
112CSF1R0.56680421
113AKT20.55050264
114CDK11A0.54858909
115EPHA20.54648447
116MELK0.54291728
117PRKDC0.54059630
118GRK60.52789243
119MAPK140.52575586
120PLK20.51707586
121CAMK1D0.51494081
122ERBB40.51009854
123PTK20.50237676
124STK30.49335604
125CDK30.47089951
126JAK30.46738837
127HCK0.46089575
128ILK0.45579898
129BLK0.44181489
130NTRK20.43813314
131MAPK10.43478160
132GSK3B0.43284325
133CSNK2A20.42940747
134AKT10.42376709
135EIF2AK30.42147865
136RAF10.40788955
137BRAF0.40674148
138CDK190.39784239
139MATK0.37461068
140KSR20.37323176
141WNK10.35014708

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.95336062
2Mismatch repair_Homo sapiens_hsa034303.37899077
3Spliceosome_Homo sapiens_hsa030402.68303823
4* Cell cycle_Homo sapiens_hsa041102.60516120
5RNA transport_Homo sapiens_hsa030132.50361093
6One carbon pool by folate_Homo sapiens_hsa006702.49799357
7mRNA surveillance pathway_Homo sapiens_hsa030152.21324655
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.20098735
9Basal cell carcinoma_Homo sapiens_hsa052171.99233852
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.92798502
11Nucleotide excision repair_Homo sapiens_hsa034201.90538050
12* MicroRNAs in cancer_Homo sapiens_hsa052061.84190752
13Base excision repair_Homo sapiens_hsa034101.83256719
14Fanconi anemia pathway_Homo sapiens_hsa034601.67036878
15Hippo signaling pathway_Homo sapiens_hsa043901.57097180
16Homologous recombination_Homo sapiens_hsa034401.55451448
17* Chronic myeloid leukemia_Homo sapiens_hsa052201.51687425
18Colorectal cancer_Homo sapiens_hsa052101.51410730
19Oocyte meiosis_Homo sapiens_hsa041141.47640243
20Ribosome_Homo sapiens_hsa030101.44306861
21Hedgehog signaling pathway_Homo sapiens_hsa043401.37205652
22Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.32705970
23Adherens junction_Homo sapiens_hsa045201.31277299
24Proteoglycans in cancer_Homo sapiens_hsa052051.30914956
25Non-homologous end-joining_Homo sapiens_hsa034501.28445573
26mTOR signaling pathway_Homo sapiens_hsa041501.26757732
27Measles_Homo sapiens_hsa051621.26393420
28p53 signaling pathway_Homo sapiens_hsa041151.26256460
29Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.24705746
30Notch signaling pathway_Homo sapiens_hsa043301.24496069
31Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.24427623
32Thyroid cancer_Homo sapiens_hsa052161.24151502
33Central carbon metabolism in cancer_Homo sapiens_hsa052301.23072540
34* Glioma_Homo sapiens_hsa052141.23027851
35RNA degradation_Homo sapiens_hsa030181.22533999
36Lysine degradation_Homo sapiens_hsa003101.20769476
37* Small cell lung cancer_Homo sapiens_hsa052221.16113275
38Wnt signaling pathway_Homo sapiens_hsa043101.14215410
39Viral carcinogenesis_Homo sapiens_hsa052031.14095721
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.13031704
41NOD-like receptor signaling pathway_Homo sapiens_hsa046211.12969902
42* Non-small cell lung cancer_Homo sapiens_hsa052231.12316191
43Endometrial cancer_Homo sapiens_hsa052131.09987098
44* HTLV-I infection_Homo sapiens_hsa051661.09720151
45Proteasome_Homo sapiens_hsa030501.09228943
46TGF-beta signaling pathway_Homo sapiens_hsa043501.08467129
47Axon guidance_Homo sapiens_hsa043601.06057390
48Toll-like receptor signaling pathway_Homo sapiens_hsa046201.03959043
49NF-kappa B signaling pathway_Homo sapiens_hsa040641.03387902
50Focal adhesion_Homo sapiens_hsa045101.02814943
51Renal cell carcinoma_Homo sapiens_hsa052111.02683733
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.01012346
53RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.00635382
54Legionellosis_Homo sapiens_hsa051340.94926003
55Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.94826949
56Neurotrophin signaling pathway_Homo sapiens_hsa047220.94465632
57Osteoclast differentiation_Homo sapiens_hsa043800.91718881
58* Pathways in cancer_Homo sapiens_hsa052000.91688242
59Influenza A_Homo sapiens_hsa051640.89370889
60Viral myocarditis_Homo sapiens_hsa054160.89286535
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.89206321
62Thyroid hormone signaling pathway_Homo sapiens_hsa049190.88553772
63Apoptosis_Homo sapiens_hsa042100.88481830
64Leishmaniasis_Homo sapiens_hsa051400.86434532
65ErbB signaling pathway_Homo sapiens_hsa040120.86073489
66Systemic lupus erythematosus_Homo sapiens_hsa053220.85843464
67Regulation of actin cytoskeleton_Homo sapiens_hsa048100.84821424
68Melanogenesis_Homo sapiens_hsa049160.84806417
69* Bladder cancer_Homo sapiens_hsa052190.81968953
70Epstein-Barr virus infection_Homo sapiens_hsa051690.81519801
71* Prostate cancer_Homo sapiens_hsa052150.79689314
72* Melanoma_Homo sapiens_hsa052180.79027211
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.78998281
74Tight junction_Homo sapiens_hsa045300.76667771
75* Pancreatic cancer_Homo sapiens_hsa052120.76548264
76HIF-1 signaling pathway_Homo sapiens_hsa040660.75521380
77VEGF signaling pathway_Homo sapiens_hsa043700.74756951
78Pyrimidine metabolism_Homo sapiens_hsa002400.74550421
79T cell receptor signaling pathway_Homo sapiens_hsa046600.73977764
80Selenocompound metabolism_Homo sapiens_hsa004500.70904178
81Cysteine and methionine metabolism_Homo sapiens_hsa002700.70706331
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70658023
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69845221
84Dorso-ventral axis formation_Homo sapiens_hsa043200.69801117
85Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.69761320
86* Hepatitis B_Homo sapiens_hsa051610.69432026
87Gap junction_Homo sapiens_hsa045400.69430012
88Rap1 signaling pathway_Homo sapiens_hsa040150.69321459
89Alcoholism_Homo sapiens_hsa050340.69083099
90Purine metabolism_Homo sapiens_hsa002300.68960283
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68097315
92Hepatitis C_Homo sapiens_hsa051600.67388874
93Estrogen signaling pathway_Homo sapiens_hsa049150.67125546
94AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64634779
95Acute myeloid leukemia_Homo sapiens_hsa052210.64517618
96PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64469129
97Shigellosis_Homo sapiens_hsa051310.64453801
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63377557
99TNF signaling pathway_Homo sapiens_hsa046680.62929442
100Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.61620346
101ECM-receptor interaction_Homo sapiens_hsa045120.60793035
102Leukocyte transendothelial migration_Homo sapiens_hsa046700.58647009
103Prolactin signaling pathway_Homo sapiens_hsa049170.58019819
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57828771
105Platelet activation_Homo sapiens_hsa046110.55900387
106B cell receptor signaling pathway_Homo sapiens_hsa046620.54928758
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54773901
108Chemokine signaling pathway_Homo sapiens_hsa040620.54379951
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54060209
110Basal transcription factors_Homo sapiens_hsa030220.53530913
111Long-term potentiation_Homo sapiens_hsa047200.52455368
112Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52389455
113RNA polymerase_Homo sapiens_hsa030200.51067814
114Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50805623
115FoxO signaling pathway_Homo sapiens_hsa040680.50585284
116Pentose phosphate pathway_Homo sapiens_hsa000300.49387313
117Dilated cardiomyopathy_Homo sapiens_hsa054140.48300011
118Biosynthesis of amino acids_Homo sapiens_hsa012300.48058439
119Herpes simplex infection_Homo sapiens_hsa051680.47343707
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.47056390
121Tuberculosis_Homo sapiens_hsa051520.46561249
122MAPK signaling pathway_Homo sapiens_hsa040100.45925287
123Malaria_Homo sapiens_hsa051440.45814890
124Jak-STAT signaling pathway_Homo sapiens_hsa046300.45741956
125Primary immunodeficiency_Homo sapiens_hsa053400.45103379
126Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.43803602
127Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42035797
128Choline metabolism in cancer_Homo sapiens_hsa052310.41719335
129Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.41131518
130Toxoplasmosis_Homo sapiens_hsa051450.39965870
131GnRH signaling pathway_Homo sapiens_hsa049120.36335628
132AMPK signaling pathway_Homo sapiens_hsa041520.35958721
133Dopaminergic synapse_Homo sapiens_hsa047280.34990807
134Oxytocin signaling pathway_Homo sapiens_hsa049210.34777829

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