E2F1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication initiation (GO:0006270)4.85453507
2DNA replication checkpoint (GO:0000076)4.83995773
3DNA strand elongation involved in DNA replication (GO:0006271)4.82052391
4DNA unwinding involved in DNA replication (GO:0006268)4.80260374
5protein localization to kinetochore (GO:0034501)4.74770925
6DNA strand elongation (GO:0022616)4.57362311
7telomere maintenance via semi-conservative replication (GO:0032201)4.46874451
8protein localization to chromosome, centromeric region (GO:0071459)4.27196804
9mitotic sister chromatid segregation (GO:0000070)4.26591223
10regulation of translational fidelity (GO:0006450)4.25197544
11regulation of mammary gland epithelial cell proliferation (GO:0033599)4.13439342
12* regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.12119402
13mitotic chromosome condensation (GO:0007076)4.09911092
14telomere maintenance via recombination (GO:0000722)4.04704840
15mitotic metaphase plate congression (GO:0007080)3.99734952
16mitotic nuclear envelope disassembly (GO:0007077)3.97701208
17proline biosynthetic process (GO:0006561)3.97541289
18DNA replication-dependent nucleosome organization (GO:0034723)3.90380018
19DNA replication-dependent nucleosome assembly (GO:0006335)3.90380018
20mitotic recombination (GO:0006312)3.85219188
21chromosome condensation (GO:0030261)3.84833863
22sister chromatid segregation (GO:0000819)3.79023570
23kinetochore organization (GO:0051383)3.75006190
24maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.69430139
25ribosomal small subunit biogenesis (GO:0042274)3.69383459
26heterochromatin organization (GO:0070828)3.69283988
27membrane disassembly (GO:0030397)3.68779792
28nuclear envelope disassembly (GO:0051081)3.68779792
29nuclear pore organization (GO:0006999)3.67711987
30establishment of integrated proviral latency (GO:0075713)3.67565221
31spliceosomal tri-snRNP complex assembly (GO:0000244)3.67393032
32protein K6-linked ubiquitination (GO:0085020)3.61830066
33nuclear pore complex assembly (GO:0051292)3.61029603
34kinetochore assembly (GO:0051382)3.58640923
35nucleotide-excision repair, DNA gap filling (GO:0006297)3.55539974
36folic acid-containing compound biosynthetic process (GO:0009396)3.55382281
37DNA synthesis involved in DNA repair (GO:0000731)3.54020722
38meiotic chromosome segregation (GO:0045132)3.52926785
39metaphase plate congression (GO:0051310)3.52115086
40telomere maintenance via telomere lengthening (GO:0010833)3.51136515
41DNA topological change (GO:0006265)3.49825209
42nucleobase-containing small molecule interconversion (GO:0015949)3.48625534
43peptidyl-arginine omega-N-methylation (GO:0035247)3.43873917
44protein complex localization (GO:0031503)3.41273398
45mitotic sister chromatid cohesion (GO:0007064)3.40767454
46regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.40594074
47chromatin assembly or disassembly (GO:0006333)3.37224224
48negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.33784774
49DNA packaging (GO:0006323)3.29180865
50chromatin remodeling at centromere (GO:0031055)3.29134129
51deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.29069706
52attachment of spindle microtubules to kinetochore (GO:0008608)3.28949725
53regulation of translational termination (GO:0006449)3.28365453
54DNA replication-independent nucleosome assembly (GO:0006336)3.28313393
55DNA replication-independent nucleosome organization (GO:0034724)3.28313393
56regulation of double-strand break repair via homologous recombination (GO:0010569)3.26873355
57Golgi transport vesicle coating (GO:0048200)3.26224038
58COPI coating of Golgi vesicle (GO:0048205)3.26224038
59viral mRNA export from host cell nucleus (GO:0046784)3.25224562
60DNA duplex unwinding (GO:0032508)3.24757116
61DNA geometric change (GO:0032392)3.24753122
62CENP-A containing nucleosome assembly (GO:0034080)3.24594414
63folic acid metabolic process (GO:0046655)3.22329013
64replication fork processing (GO:0031297)3.20922949
65regulation of spindle organization (GO:0090224)3.18893690
66IMP biosynthetic process (GO:0006188)3.18449135
67establishment of chromosome localization (GO:0051303)3.17794009
68negative regulation of mRNA metabolic process (GO:1903312)3.17312971
69translesion synthesis (GO:0019985)3.15880771
70protein-DNA complex disassembly (GO:0032986)3.15878854
71nucleosome disassembly (GO:0006337)3.15878854
72DNA damage response, signal transduction resulting in transcription (GO:0042772)3.14954432
73chromatin assembly (GO:0031497)3.13221514
74DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.11976465
75positive regulation of chromosome segregation (GO:0051984)3.10484197
76regulation of nuclear cell cycle DNA replication (GO:0033262)3.10461897
77chromosome segregation (GO:0007059)3.08120913
78somatic diversification of immune receptors via somatic mutation (GO:0002566)3.07604200
79somatic hypermutation of immunoglobulin genes (GO:0016446)3.07604200
80cellular protein complex localization (GO:0034629)3.07443765
81protein localization to chromosome (GO:0034502)3.07106252
82regulation of double-strand break repair (GO:2000779)3.06526403
83mismatch repair (GO:0006298)3.03624075
84protein maturation by protein folding (GO:0022417)3.00148462
85negative regulation of RNA splicing (GO:0033119)3.00135742
86positive regulation of DNA-dependent DNA replication (GO:2000105)2.99563081
87regulation of sister chromatid cohesion (GO:0007063)2.97765383
88negative regulation of mRNA processing (GO:0050686)2.96325746
89DNA deamination (GO:0045006)2.93059302
90establishment of viral latency (GO:0019043)2.92886235
91regulation of chromosome segregation (GO:0051983)2.92259833
92nuclear envelope organization (GO:0006998)2.92160484
93dosage compensation (GO:0007549)2.91222532
94histone arginine methylation (GO:0034969)2.91131269
95base-excision repair (GO:0006284)2.91004414
96rRNA transcription (GO:0009303)2.89342607
97pore complex assembly (GO:0046931)2.88985099
98regulation of mitotic spindle organization (GO:0060236)2.88863029
99L-serine metabolic process (GO:0006563)2.87775269
100DNA conformation change (GO:0071103)2.87520416
101negative regulation of chromosome segregation (GO:0051985)2.85909803
102mitotic G1 DNA damage checkpoint (GO:0031571)2.84886354
103deoxyribonucleotide biosynthetic process (GO:0009263)2.84276115
104formation of translation preinitiation complex (GO:0001731)2.83511950
105IMP metabolic process (GO:0046040)2.81122929
106ribosome biogenesis (GO:0042254)2.80588129
107regulation of mitotic metaphase/anaphase transition (GO:0030071)2.79874990
108positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.79205928
109positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.79205928
110positive regulation of mitotic sister chromatid separation (GO:1901970)2.79205928
111spindle checkpoint (GO:0031577)2.79162091
112mitotic nuclear envelope reassembly (GO:0007084)2.79127507
113nuclear envelope reassembly (GO:0031468)2.79127507
114intra-S DNA damage checkpoint (GO:0031573)2.78787944
115pre-miRNA processing (GO:0031054)2.77707067
116regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.76962788
117peptidyl-arginine N-methylation (GO:0035246)2.74932826
118peptidyl-arginine methylation (GO:0018216)2.74932826
119histone exchange (GO:0043486)2.74807853
120DNA replication (GO:0006260)2.73283092
121spindle assembly checkpoint (GO:0071173)2.72555975
122postreplication repair (GO:0006301)2.72293315
123maturation of SSU-rRNA (GO:0030490)2.72125517
124regulation of chromatin binding (GO:0035561)2.72100684
125telomere maintenance (GO:0000723)2.72050712
126nucleobase biosynthetic process (GO:0046112)2.71583142
127negative regulation of mitotic sister chromatid separation (GO:2000816)2.71568704
128negative regulation of mitotic sister chromatid segregation (GO:0033048)2.71568704
129negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.71568704
130negative regulation of sister chromatid segregation (GO:0033046)2.71568704
131regulation of centrosome cycle (GO:0046605)2.71144252
132ribonucleoprotein complex biogenesis (GO:0022613)2.70170036
133telomere organization (GO:0032200)2.69760857
1343-UTR-mediated mRNA stabilization (GO:0070935)2.68516883
135protein export from nucleus (GO:0006611)2.68410122
136ATP-dependent chromatin remodeling (GO:0043044)2.68158260
137negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.68044274
138mitotic spindle assembly checkpoint (GO:0007094)2.67294375
139pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.66787277
140DNA biosynthetic process (GO:0071897)2.65881791
141transcription-coupled nucleotide-excision repair (GO:0006283)2.63645241
142G1 DNA damage checkpoint (GO:0044783)2.63343395
143apoptotic process involved in morphogenesis (GO:0060561)2.62869680
144regulation of RNA export from nucleus (GO:0046831)2.61100172
145protein retention in ER lumen (GO:0006621)2.60381747
146pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.58507673
147non-recombinational repair (GO:0000726)2.56433861
148double-strand break repair via nonhomologous end joining (GO:0006303)2.56433861
149mitochondrial DNA metabolic process (GO:0032042)2.54683636
150proline metabolic process (GO:0006560)2.54670760

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.44609271
2E2F4_17652178_ChIP-ChIP_JURKAT_Human3.94286962
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.72044153
4* MYC_18555785_ChIP-Seq_MESCs_Mouse3.46560445
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.15368290
6* MYC_22102868_ChIP-Seq_BL_Human2.53620366
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.52046708
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.47441415
9E2F1_21310950_ChIP-Seq_MCF-7_Human2.42549172
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.32568204
11TP63_19390658_ChIP-ChIP_HaCaT_Human2.30414924
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.17420756
13E2F7_22180533_ChIP-Seq_HELA_Human10.8013532
14NELFA_20434984_ChIP-Seq_ESCs_Mouse1.95885139
15* AR_21909140_ChIP-Seq_LNCAP_Human1.92051438
16* XRN2_22483619_ChIP-Seq_HELA_Human1.87759152
17VDR_21846776_ChIP-Seq_THP-1_Human1.87647248
18ZNF263_19887448_ChIP-Seq_K562_Human1.84549411
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.81681772
20ETS1_20019798_ChIP-Seq_JURKAT_Human1.71916729
21KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.70893713
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.70137790
23* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.68424771
24MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.67201840
25EST1_17652178_ChIP-ChIP_JURKAT_Human1.65308978
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.64869233
27CREB1_15753290_ChIP-ChIP_HEK293T_Human1.63635699
28NANOG_18555785_ChIP-Seq_MESCs_Mouse1.63125508
29JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.60971749
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.58517188
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.55489904
32CIITA_25753668_ChIP-Seq_RAJI_Human1.55436639
33VDR_23849224_ChIP-Seq_CD4+_Human1.55118528
34TTF2_22483619_ChIP-Seq_HELA_Human1.53803880
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.53364490
36GABP_19822575_ChIP-Seq_HepG2_Human1.53268882
37LXR_22292898_ChIP-Seq_THP-1_Human1.53031212
38FOXP3_21729870_ChIP-Seq_TREG_Human1.51688882
39KDM5A_27292631_Chip-Seq_BREAST_Human1.51393842
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.50558260
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.50267186
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.48859961
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.48386370
44ESR1_15608294_ChIP-ChIP_MCF-7_Human1.47860647
45HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.44696285
46NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.44372466
47GABP_17652178_ChIP-ChIP_JURKAT_Human1.43239795
48DCP1A_22483619_ChIP-Seq_HELA_Human1.42164970
49RACK7_27058665_Chip-Seq_MCF-7_Human1.40780505
50DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.39548360
51ZFX_18555785_ChIP-Seq_MESCs_Mouse1.38025945
52SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.37884996
53PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.37259652
54SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.36915142
55* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.35166077
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31514722
57NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.27671630
58TET1_21451524_ChIP-Seq_MESCs_Mouse1.23116523
59THAP11_20581084_ChIP-Seq_MESCs_Mouse1.22876329
60E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.22624995
61YY1_21170310_ChIP-Seq_MESCs_Mouse1.19467775
62HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.18994093
63PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18966311
64NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.17870224
65TP63_17297297_ChIP-ChIP_HaCaT_Human1.16875057
66TFEB_21752829_ChIP-Seq_HELA_Human1.16702015
67YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14828554
68SCL_19346495_ChIP-Seq_HPC-7_Human1.14606558
69ELF1_17652178_ChIP-ChIP_JURKAT_Human1.14011941
70TCF7_22412390_ChIP-Seq_EML_Mouse1.13047400
71HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12344949
72TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12171872
73* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.11722978
74POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.10863810
75STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09534262
76KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.08448407
77KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.08448407
78KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.08448407
79NOTCH1_21737748_ChIP-Seq_TLL_Human1.08185042
80TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08090365
81SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08010355
82* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07454733
83FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.06774957
84ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06545962
85P68_20966046_ChIP-Seq_HELA_Human1.05591531
86KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04336896
87* SPI1_23547873_ChIP-Seq_NB4_Human1.04242483
88KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03322783
89* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01798821
90NANOG_21062744_ChIP-ChIP_HESCs_Human1.01783932
91* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01039909
92* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.00280628
93PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.99921809
94SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.99581123
95* UTX_26944678_Chip-Seq_JUKART_Human0.99369824
96ATF3_27146783_Chip-Seq_COLON_Human0.99200458
97GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98930067
98SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.98561988
99ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.97764707
100MYB_21317192_ChIP-Seq_ERMYB_Mouse0.96531574
101ELK1_19687146_ChIP-ChIP_HELA_Human0.96080413
102SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96050912
103RARG_19884340_ChIP-ChIP_MEFs_Mouse0.95814617
104FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.95756965
105* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.94800730
106KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.94378350
107EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93039753
108MAF_26560356_Chip-Seq_TH1_Human0.92033417
109TBX5_21415370_ChIP-Seq_HL-1_Mouse0.91772171
110SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.91493063
111MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.91288313
112PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.89784718
113BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89523189
114ELK3_25401928_ChIP-Seq_HUVEC_Human0.89455684
115CHD1_26751641_Chip-Seq_LNCaP_Human0.89450202
116CTCF_27219007_Chip-Seq_ERYTHROID_Human0.88919839
117HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.88816502
118KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.88753849
119ZFP281_18757296_ChIP-ChIP_E14_Mouse0.88606706
120ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.87928683
121CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86809039
122VDR_24763502_ChIP-Seq_THP-1_Human0.86576819
123RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86365277
124BRD4_27068464_Chip-Seq_AML-cells_Mouse0.84378356
125* MYB_26560356_Chip-Seq_TH1_Human0.83312724
126RUNX1_22412390_ChIP-Seq_EML_Mouse0.83068692
127HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.81957106
128NCOR1_26117541_ChIP-Seq_K562_Human0.81438792
129KDM2B_26808549_Chip-Seq_DND41_Human0.78705540

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.41095101
2MP0010094_abnormal_chromosome_stability4.23144203
3* MP0003111_abnormal_nucleus_morphology4.14516343
4MP0004957_abnormal_blastocyst_morpholog3.53550079
5* MP0003077_abnormal_cell_cycle3.47651778
6MP0008057_abnormal_DNA_replication3.41654576
7MP0002396_abnormal_hematopoietic_system2.74566715
8MP0008007_abnormal_cellular_replicative2.46866743
9MP0005451_abnormal_body_composition2.42068842
10MP0010352_gastrointestinal_tract_polyps2.36844366
11MP0008058_abnormal_DNA_repair2.31386924
12MP0008932_abnormal_embryonic_tissue2.22324250
13* MP0000350_abnormal_cell_proliferation2.15832263
14MP0000490_abnormal_crypts_of2.14921358
15MP0010307_abnormal_tumor_latency2.13306787
16MP0001730_embryonic_growth_arrest1.99261647
17MP0010030_abnormal_orbit_morphology1.92835218
18MP0001545_abnormal_hematopoietic_system1.91416879
19MP0005397_hematopoietic_system_phenotyp1.91416879
20MP0010234_abnormal_vibrissa_follicle1.89404011
21MP0005076_abnormal_cell_differentiation1.88517788
22MP0000537_abnormal_urethra_morphology1.87833226
23MP0004808_abnormal_hematopoietic_stem1.87158799
24MP0005257_abnormal_intraocular_pressure1.85339988
25MP0009278_abnormal_bone_marrow1.76306765
26MP0001672_abnormal_embryogenesis/_devel1.72089247
27MP0005380_embryogenesis_phenotype1.72089247
28MP0004233_abnormal_muscle_weight1.67151633
29MP0005623_abnormal_meninges_morphology1.66582997
30MP0002085_abnormal_embryonic_tissue1.66365436
31MP0002877_abnormal_melanocyte_morpholog1.65169396
32MP0008877_abnormal_DNA_methylation1.63623018
33MP0003123_paternal_imprinting1.62394930
34MP0001697_abnormal_embryo_size1.60455302
35MP0003984_embryonic_growth_retardation1.57665023
36MP0002088_abnormal_embryonic_growth/wei1.53571397
37MP0002084_abnormal_developmental_patter1.52225023
38MP0003786_premature_aging1.46491209
39MP0002086_abnormal_extraembryonic_tissu1.44734608
40MP0006292_abnormal_olfactory_placode1.44496163
41MP0003705_abnormal_hypodermis_morpholog1.44045936
42* MP0002080_prenatal_lethality1.42769988
43* MP0002019_abnormal_tumor_incidence1.42178843
44* MP0000313_abnormal_cell_death1.37519569
45MP0009333_abnormal_splenocyte_physiolog1.32501253
46MP0003121_genomic_imprinting1.32309665
47MP0004197_abnormal_fetal_growth/weight/1.31820298
48MP0002653_abnormal_ependyma_morphology1.30818624
49* MP0005501_abnormal_skin_physiology1.27354332
50MP0001293_anophthalmia1.20336078
51MP0001348_abnormal_lacrimal_gland1.20162700
52MP0001661_extended_life_span1.19910802
53MP0003890_abnormal_embryonic-extraembry1.18140012
54MP0005058_abnormal_lysosome_morphology1.16696517
55MP0002089_abnormal_postnatal_growth/wei1.15243284
56* MP0002210_abnormal_sex_determination1.14133124
57* MP0002398_abnormal_bone_marrow1.12995500
58MP0008260_abnormal_autophagy1.10822961
59MP0002796_impaired_skin_barrier1.10776833
60MP0001849_ear_inflammation1.09258126
61MP0002009_preneoplasia1.09161437
62* MP0000703_abnormal_thymus_morphology1.08652932
63MP0009697_abnormal_copulation1.05683949
64MP0004858_abnormal_nervous_system1.03545008
65MP0000733_abnormal_muscle_development1.03368158
66MP0001915_intracranial_hemorrhage1.01435496
67MP0003453_abnormal_keratinocyte_physiol1.01381192
68* MP0004185_abnormal_adipocyte_glucose0.99387579
69MP0003566_abnormal_cell_adhesion0.99066874
70MP0000358_abnormal_cell_content/0.98844797
71* MP0002722_abnormal_immune_system0.97291245
72MP0003567_abnormal_fetal_cardiomyocyte0.96633792
73MP0000689_abnormal_spleen_morphology0.96553886
74MP0009053_abnormal_anal_canal0.95820704
75MP0003718_maternal_effect0.95262225
76* MP0001145_abnormal_male_reproductive0.94521706
77MP0003942_abnormal_urinary_system0.93610650
78MP0000428_abnormal_craniofacial_morphol0.92782863
79* MP0001119_abnormal_female_reproductive0.90522380
80MP0003937_abnormal_limbs/digits/tail_de0.90205947
81MP0005621_abnormal_cell_physiology0.89173896
82MP0003448_altered_tumor_morphology0.85765744
83MP0002249_abnormal_larynx_morphology0.85581900
84MP0002060_abnormal_skin_morphology0.84534699
85MP0000432_abnormal_head_morphology0.84063693
86MP0003303_peritoneal_inflammation0.83819282
87* MP0002429_abnormal_blood_cell0.82822955
88MP0000678_abnormal_parathyroid_gland0.82611611
89* MP0000653_abnormal_sex_gland0.82462473
90MP0009672_abnormal_birth_weight0.81906071
91MP0003935_abnormal_craniofacial_develop0.81903126
92MP0003656_abnormal_erythrocyte_physiolo0.81413263
93* MP0000858_altered_metastatic_potential0.81104173
94MP0005409_darkened_coat_color0.80569655
95MP0003763_abnormal_thymus_physiology0.80445105
96MP0003315_abnormal_perineum_morphology0.79871467
97MP0001929_abnormal_gametogenesis0.78997963
98MP0003385_abnormal_body_wall0.78143371
99MP0002925_abnormal_cardiovascular_devel0.78001865
100MP0002111_abnormal_tail_morphology0.77754687
101MP0005384_cellular_phenotype0.77576871
102MP0005023_abnormal_wound_healing0.76802122
103MP0002092_abnormal_eye_morphology0.76316005
104MP0002075_abnormal_coat/hair_pigmentati0.74665066
105MP0003119_abnormal_digestive_system0.74623725
106MP0006035_abnormal_mitochondrial_morpho0.74552098
107MP0002697_abnormal_eye_size0.74347178
108MP0000477_abnormal_intestine_morphology0.74162422
109MP0009703_decreased_birth_body0.73856235
110MP0001216_abnormal_epidermal_layer0.73579247
111MP0000049_abnormal_middle_ear0.73483507
112MP0003755_abnormal_palate_morphology0.73324655
113MP0003943_abnormal_hepatobiliary_system0.72337579
114MP0004264_abnormal_extraembryonic_tissu0.71302425
115MP0002932_abnormal_joint_morphology0.71153861
116* MP0003861_abnormal_nervous_system0.71013635
117MP0000627_abnormal_mammary_gland0.70041387
118MP0009931_abnormal_skin_appearance0.69822749
119MP0002405_respiratory_system_inflammati0.69338076
120MP0002098_abnormal_vibrissa_morphology0.68984056
121MP0001881_abnormal_mammary_gland0.68623207
122MP0000534_abnormal_ureter_morphology0.68393939
123MP0002116_abnormal_craniofacial_bone0.68135018
124MP0002132_abnormal_respiratory_system0.68126335
125* MP0000716_abnormal_immune_system0.67400206
126MP0010630_abnormal_cardiac_muscle0.66012121
127MP0002114_abnormal_axial_skeleton0.65251689
128* MP0003699_abnormal_female_reproductive0.63645222
129MP0000566_synostosis0.62465204
130MP0003828_pulmonary_edema0.62320337
131MP0003115_abnormal_respiratory_system0.62238724
132MP0000762_abnormal_tongue_morphology0.61594438
133MP0005508_abnormal_skeleton_morphology0.61209513
134MP0000747_muscle_weakness0.60030493

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.41679880
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.27901401
3Birth length less than 3rd percentile (HP:0003561)4.22528309
4Patellar aplasia (HP:0006443)3.58695021
5Aplasia/Hypoplasia of the patella (HP:0006498)3.31619925
6Breast hypoplasia (HP:0003187)3.17841720
7Meckel diverticulum (HP:0002245)3.08482067
8Aplasia/Hypoplasia of the uvula (HP:0010293)3.03734489
9Abnormality of the ileum (HP:0001549)3.03090809
10Ectopic kidney (HP:0000086)3.01581846
11Abnormality of chromosome stability (HP:0003220)3.01032725
12Ependymoma (HP:0002888)2.97821529
13Aplasia/Hypoplasia of the sacrum (HP:0008517)2.88404768
14Abnormality of the preputium (HP:0100587)2.85723597
15Reticulocytopenia (HP:0001896)2.83132778
16Broad distal phalanx of finger (HP:0009836)2.81677343
17Progressive muscle weakness (HP:0003323)2.81302500
18Myelodysplasia (HP:0002863)2.66873539
19Insomnia (HP:0100785)2.65836223
20Rib fusion (HP:0000902)2.64833107
21Microvesicular hepatic steatosis (HP:0001414)2.63489016
22Rhabdomyosarcoma (HP:0002859)2.63128805
23Abnormality of the fingertips (HP:0001211)2.59636358
24Selective tooth agenesis (HP:0001592)2.56525863
25Asymmetry of the thorax (HP:0001555)2.52489377
26Achilles tendon contracture (HP:0001771)2.50852075
27Abnormality of the carotid arteries (HP:0005344)2.49335399
28Genu recurvatum (HP:0002816)2.47634023
29Slender long bone (HP:0003100)2.46663418
30Medulloblastoma (HP:0002885)2.40121513
31Impulsivity (HP:0100710)2.39324240
32Absent thumb (HP:0009777)2.39143789
33Duodenal stenosis (HP:0100867)2.36986397
34Small intestinal stenosis (HP:0012848)2.36986397
35Increased nuchal translucency (HP:0010880)2.36125632
36Facial hemangioma (HP:0000329)2.34279210
37Absent radius (HP:0003974)2.33192458
38Agnosia (HP:0010524)2.28692453
39Septate vagina (HP:0001153)2.27543033
40Prominent nose (HP:0000448)2.26992243
41Abnormality of the Achilles tendon (HP:0005109)2.26291343
42Atresia of the external auditory canal (HP:0000413)2.25485075
43Tracheoesophageal fistula (HP:0002575)2.25049739
44Astrocytoma (HP:0009592)2.24562568
45Abnormality of the astrocytes (HP:0100707)2.24562568
46Basal cell carcinoma (HP:0002671)2.23525908
47Multiple enchondromatosis (HP:0005701)2.20344739
48Abnormality of the umbilical cord (HP:0010881)2.20259091
49Long palpebral fissure (HP:0000637)2.19895269
50Bone marrow hypocellularity (HP:0005528)2.17120934
51Absent forearm bone (HP:0003953)2.16389161
52Aplasia involving forearm bones (HP:0009822)2.16389161
53Renal duplication (HP:0000075)2.15278574
54Neoplasm of striated muscle (HP:0009728)2.14349569
55Long eyelashes (HP:0000527)2.14104885
56Duplication of thumb phalanx (HP:0009942)2.12581760
57High anterior hairline (HP:0009890)2.11401103
58Volvulus (HP:0002580)2.10101492
59Clubbing of toes (HP:0100760)2.07548806
60Abnormality of the labia minora (HP:0012880)2.06448143
61Abnormality of the phalanges of the hallux (HP:0010057)2.05652821
62Orthostatic hypotension (HP:0001278)2.05195235
63Cafe-au-lait spot (HP:0000957)2.04560744
64Duplicated collecting system (HP:0000081)2.04453682
65Sloping forehead (HP:0000340)2.04224745
66High pitched voice (HP:0001620)2.04177279
67Abnormal gallbladder physiology (HP:0012438)2.03608818
68Cholecystitis (HP:0001082)2.03608818
69Abnormality of the anterior horn cell (HP:0006802)2.03037815
70Degeneration of anterior horn cells (HP:0002398)2.03037815
71Deep palmar crease (HP:0006191)2.02619401
72Overlapping toe (HP:0001845)2.02446766
73Broad face (HP:0000283)2.00998963
74Abnormality of cochlea (HP:0000375)1.99544748
75Elfin facies (HP:0004428)1.99050519
76Overriding aorta (HP:0002623)1.98770602
77Ragged-red muscle fibers (HP:0003200)1.98165744
78Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.97466739
79Short 4th metacarpal (HP:0010044)1.97466739
80Aplastic anemia (HP:0001915)1.96831705
81Vertebral compression fractures (HP:0002953)1.94883605
82Sparse lateral eyebrow (HP:0005338)1.94443439
83Premature graying of hair (HP:0002216)1.92669447
84Abnormal number of incisors (HP:0011064)1.92109114
85Abnormality of the distal phalanges of the toes (HP:0010182)1.91257888
86Abnormality of DNA repair (HP:0003254)1.91021693
87Distal lower limb amyotrophy (HP:0008944)1.90932037
88Hypoplasia of the capital femoral epiphysis (HP:0003090)1.90820602
89Abnormality of the fetal cardiovascular system (HP:0010948)1.90579252
90Abnormal umbilical cord blood vessels (HP:0011403)1.90579252
91Single umbilical artery (HP:0001195)1.90579252
92Triphalangeal thumb (HP:0001199)1.90440319
93Abnormality of the duodenum (HP:0002246)1.89523058
94Hyperacusis (HP:0010780)1.89065606
95Patellar dislocation (HP:0002999)1.87240304
96Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.86822408
97Absent epiphyses (HP:0010577)1.86822408
98Squamous cell carcinoma (HP:0002860)1.86734922
99Abnormal number of erythroid precursors (HP:0012131)1.85161987
100Deviation of the thumb (HP:0009603)1.85002366
101Poikiloderma (HP:0001029)1.84320959
102Neoplasm of the oral cavity (HP:0100649)1.84139021
103Proximal placement of thumb (HP:0009623)1.83437806
104Abnormality of the renal collecting system (HP:0004742)1.82823473
105Shawl scrotum (HP:0000049)1.81816274
106Horseshoe kidney (HP:0000085)1.81807175
107Progressive external ophthalmoplegia (HP:0000590)1.81286099
108Protrusio acetabuli (HP:0003179)1.80112703
109Abnormality of the calcaneus (HP:0008364)1.79753447
110Rough bone trabeculation (HP:0100670)1.79667331
111Abnormality of cells of the erythroid lineage (HP:0012130)1.78851836
112Neoplasm of the pancreas (HP:0002894)1.78820961
113Glioma (HP:0009733)1.78450355
114Disproportionate tall stature (HP:0001519)1.77915690
115Abnormality of the distal phalanx of the thumb (HP:0009617)1.77029455
116Oral leukoplakia (HP:0002745)1.76691531
117Trismus (HP:0000211)1.76422733
118Pseudobulbar signs (HP:0002200)1.76003106
119Short thumb (HP:0009778)1.75734134
120Self-mutilation (HP:0000742)1.74976546
121Pallor (HP:0000980)1.74451270
122Acute lymphatic leukemia (HP:0006721)1.73812534
123Reticulocytosis (HP:0001923)1.72967293
124Heterotopia (HP:0002282)1.71940463
125Entropion (HP:0000621)1.69834536
126Pointed chin (HP:0000307)1.68415535
127Short middle phalanx of the 5th finger (HP:0004220)1.68303132
128Flared metaphyses (HP:0003015)1.68095474
129Pendular nystagmus (HP:0012043)1.68073176
130Ankyloglossia (HP:0010296)1.68046181
131Arteriovenous malformation (HP:0100026)1.67626544
132Truncus arteriosus (HP:0001660)1.67052275
133Broad palm (HP:0001169)1.66672137
134Flat acetabular roof (HP:0003180)1.66410610
135Abnormality of the thoracic spine (HP:0100711)1.65833400
136Colon cancer (HP:0003003)1.64609458
137Abnormality of chromosome segregation (HP:0002916)1.64385933
138Aplasia/Hypoplasia of the sternum (HP:0006714)1.64007109
139Microretrognathia (HP:0000308)1.63595561
140Microglossia (HP:0000171)1.63139280
141Unilateral renal agenesis (HP:0000122)1.62928268
142Short 5th finger (HP:0009237)1.62443225
143Abnormality of reticulocytes (HP:0004312)1.62247531
14411 pairs of ribs (HP:0000878)1.61438632
145Acute myeloid leukemia (HP:0004808)1.61313427
146Ulnar bowing (HP:0003031)1.61158940
147Thrombocytosis (HP:0001894)1.61150264
148Premature rupture of membranes (HP:0001788)1.59517376
149Breast aplasia (HP:0100783)1.59304043
150Capillary hemangiomas (HP:0005306)1.59249856
151Testicular atrophy (HP:0000029)1.58972668
152Back pain (HP:0003418)1.58723034
153Glossoptosis (HP:0000162)1.58404304
154Facial cleft (HP:0002006)1.57638003
155Elbow flexion contracture (HP:0002987)1.57098800
156Deep philtrum (HP:0002002)1.56650170
157Choanal atresia (HP:0000453)1.56386892
158Small epiphyses (HP:0010585)1.55809244
159Ureteral duplication (HP:0000073)1.55421515
160Urethral obstruction (HP:0000796)1.54147964
161Biconcave vertebral bodies (HP:0004586)1.53996087

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.02194493
2CDK123.99160500
3SMG13.92912218
4NEK23.35139381
5IRAK33.03131495
6WEE12.79872299
7BUB12.36893038
8EEF2K2.17955127
9VRK22.17337679
10PRPF4B2.15351892
11TTK2.09865113
12LATS22.08891365
13LATS12.07557935
14EIF2AK11.89407292
15* CDK71.88075583
16RPS6KA41.83728787
17PLK11.79657605
18TLK11.79571175
19BRSK21.71699912
20SRPK11.70439874
21TRIB31.68519439
22SIK11.68452311
23CDK41.68179643
24PKN21.64318638
25ACVR1B1.61146828
26NME21.61026446
27MAP3K101.58713175
28* ATR1.56912320
29MAP3K61.54761124
30* CHEK21.49270137
31DYRK31.46582147
32BRSK11.46479542
33AURKB1.45663935
34PAK41.45035709
35TESK21.44900543
36STK101.36794739
37MKNK21.33618824
38STK31.33456916
39PBK1.33139320
40MAP4K11.31695677
41MST1R1.28459939
42CHEK11.28205288
43STK38L1.27553111
44MAP3K81.26876734
45NEK11.25362745
46ARAF1.22503330
47PLK41.21302001
48RPS6KB21.18996910
49TAOK11.17538124
50IRAK21.15682533
51BRD41.14573869
52PIM11.13843710
53MKNK11.13182787
54SCYL21.10351556
55CDK61.08159770
56VRK10.98235170
57TESK10.98062074
58TAF10.95811383
59* ATM0.95749605
60AURKA0.94290893
61* CDK20.93738715
62STK40.92176237
63FGFR40.91530678
64MAP3K110.91479572
65ILK0.88331740
66TTN0.86703063
67ALK0.86120110
68PASK0.85756208
69PIM20.80516691
70MTOR0.79427553
71EPHA20.77910600
72KDR0.76314395
73FLT30.73355236
74PLK30.72492835
75MAP2K30.70889626
76BLK0.70786232
77KIT0.67061627
78MELK0.66909960
79ICK0.66233017
80DAPK10.64948770
81LMTK20.62889893
82SIK20.62409183
83* CDK10.61131935
84KSR20.59626426
85CDK90.59113831
86CDK11A0.58609327
87HIPK20.57577752
88PTK20.57310216
89CSF1R0.56464966
90BMX0.56110822
91TSSK60.56020841
92PRKD20.55380690
93CDK150.54682854
94PAK10.54377788
95EIF2AK30.53605726
96ZAK0.52679454
97PRKCI0.51857313
98GRK60.51436236
99SIK30.51060252
100AKT20.50872743
101PRKD30.50438135
102BRAF0.49342698
103CDK180.49330583
104CCNB10.48468382
105MARK30.48409303
106MAP2K20.47715555
107MET0.47025334
108MATK0.46591527
109TAOK20.46394613
110TGFBR10.45987539
111IRAK40.45175174
112CDK140.44794981
113CLK10.44736508
114NEK90.44688685
115CSNK2A10.44078560
116CSNK2A20.43305525
117PTK60.42731976
118AKT10.41541492
119PDGFRA0.41179173
120CAMK1D0.40758751
121DDR20.38727110
122* MAPK110.38210365
123* MAPK140.37599196
124MAP3K90.37398017
125JAK30.35585272
126LRRK20.33863152
127ERN10.33747444
128RAF10.33712164
129RPS6KA60.33462817
130RPS6KC10.33448372
131RPS6KL10.33448372
132PAK20.33320573
133CAMK1G0.33278335
134RPS6KA10.32965601
135STK160.32733429
136PDPK10.32453218
137MAP3K130.31114318

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.97783591
2Mismatch repair_Homo sapiens_hsa034303.99685668
3Base excision repair_Homo sapiens_hsa034103.13618777
4* Cell cycle_Homo sapiens_hsa041103.10685019
5Homologous recombination_Homo sapiens_hsa034403.03723673
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.76798540
7RNA transport_Homo sapiens_hsa030132.61438987
8Spliceosome_Homo sapiens_hsa030402.60559394
9Nucleotide excision repair_Homo sapiens_hsa034202.56281675
10Fanconi anemia pathway_Homo sapiens_hsa034602.47486152
11One carbon pool by folate_Homo sapiens_hsa006702.29367095
12RNA polymerase_Homo sapiens_hsa030202.09028840
13Biosynthesis of amino acids_Homo sapiens_hsa012302.06284249
14Basal transcription factors_Homo sapiens_hsa030222.01107297
15p53 signaling pathway_Homo sapiens_hsa041151.91282450
16mRNA surveillance pathway_Homo sapiens_hsa030151.88419222
17Ribosome_Homo sapiens_hsa030101.71954679
18Pyrimidine metabolism_Homo sapiens_hsa002401.69899499
19Non-homologous end-joining_Homo sapiens_hsa034501.69854599
20RNA degradation_Homo sapiens_hsa030181.67946533
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.55682831
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.55414632
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.54294356
24Herpes simplex infection_Homo sapiens_hsa051681.31727134
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.27178211
26Carbon metabolism_Homo sapiens_hsa012001.20128947
27Fructose and mannose metabolism_Homo sapiens_hsa000511.16708592
28* MicroRNAs in cancer_Homo sapiens_hsa052061.15935695
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.12255847
30Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.08542297
31Thyroid cancer_Homo sapiens_hsa052161.08099057
32Viral carcinogenesis_Homo sapiens_hsa052031.07311655
33* Chronic myeloid leukemia_Homo sapiens_hsa052201.06550673
34* HTLV-I infection_Homo sapiens_hsa051661.04466404
35Transcriptional misregulation in cancer_Homo sapiens_hsa052021.02987694
36Galactose metabolism_Homo sapiens_hsa000520.98854389
37Epstein-Barr virus infection_Homo sapiens_hsa051690.98499041
38* Small cell lung cancer_Homo sapiens_hsa052220.96218342
39Notch signaling pathway_Homo sapiens_hsa043300.94108836
40Colorectal cancer_Homo sapiens_hsa052100.91834683
41Cysteine and methionine metabolism_Homo sapiens_hsa002700.89331490
42mTOR signaling pathway_Homo sapiens_hsa041500.87865129
43Acute myeloid leukemia_Homo sapiens_hsa052210.85759249
44Apoptosis_Homo sapiens_hsa042100.85038823
45Sulfur relay system_Homo sapiens_hsa041220.84901344
46Oocyte meiosis_Homo sapiens_hsa041140.84159175
47Alcoholism_Homo sapiens_hsa050340.84017394
48* Hepatitis B_Homo sapiens_hsa051610.80315742
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79697731
50Systemic lupus erythematosus_Homo sapiens_hsa053220.79623952
51Proteasome_Homo sapiens_hsa030500.79242471
52* Bladder cancer_Homo sapiens_hsa052190.79197532
53* Pancreatic cancer_Homo sapiens_hsa052120.77870058
54Antigen processing and presentation_Homo sapiens_hsa046120.76849933
55TGF-beta signaling pathway_Homo sapiens_hsa043500.73880945
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.73236470
57Purine metabolism_Homo sapiens_hsa002300.73051551
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72777837
59Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71208040
60Shigellosis_Homo sapiens_hsa051310.70730725
61Vitamin B6 metabolism_Homo sapiens_hsa007500.70329613
62* Glioma_Homo sapiens_hsa052140.70028788
63Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.69095594
64* Non-small cell lung cancer_Homo sapiens_hsa052230.68169577
65Measles_Homo sapiens_hsa051620.66592340
66Hippo signaling pathway_Homo sapiens_hsa043900.66422510
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66330238
68Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.64021414
69Lysine degradation_Homo sapiens_hsa003100.61555864
70Endometrial cancer_Homo sapiens_hsa052130.61450646
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.57922265
72HIF-1 signaling pathway_Homo sapiens_hsa040660.57375758
73Leishmaniasis_Homo sapiens_hsa051400.56572868
74Adherens junction_Homo sapiens_hsa045200.55860072
75Influenza A_Homo sapiens_hsa051640.55601192
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55310973
77NF-kappa B signaling pathway_Homo sapiens_hsa040640.55235168
78* Prostate cancer_Homo sapiens_hsa052150.55188841
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.55019577
80B cell receptor signaling pathway_Homo sapiens_hsa046620.54992041
81Basal cell carcinoma_Homo sapiens_hsa052170.54792944
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53269756
83Folate biosynthesis_Homo sapiens_hsa007900.53232553
84Insulin signaling pathway_Homo sapiens_hsa049100.53125194
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51902771
86Legionellosis_Homo sapiens_hsa051340.51099142
87Hematopoietic cell lineage_Homo sapiens_hsa046400.50631691
88AMPK signaling pathway_Homo sapiens_hsa041520.50341222
89* Pathways in cancer_Homo sapiens_hsa052000.49765861
90* Melanoma_Homo sapiens_hsa052180.49532111
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49510520
92Primary immunodeficiency_Homo sapiens_hsa053400.49492243
93Pyruvate metabolism_Homo sapiens_hsa006200.48942903
94Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48307542
95ErbB signaling pathway_Homo sapiens_hsa040120.47943615
96Prolactin signaling pathway_Homo sapiens_hsa049170.47583443
97Prion diseases_Homo sapiens_hsa050200.47388150
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46952090
99Pentose phosphate pathway_Homo sapiens_hsa000300.46036586
100Jak-STAT signaling pathway_Homo sapiens_hsa046300.45418568
101Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45396101
102Proteoglycans in cancer_Homo sapiens_hsa052050.45050084
103Neurotrophin signaling pathway_Homo sapiens_hsa047220.44413588
104AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44147708
105Fatty acid elongation_Homo sapiens_hsa000620.43228441
106Viral myocarditis_Homo sapiens_hsa054160.43117333
107VEGF signaling pathway_Homo sapiens_hsa043700.42179587
108FoxO signaling pathway_Homo sapiens_hsa040680.41601904
109Intestinal immune network for IgA production_Homo sapiens_hsa046720.40917797
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40468910
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40214795
112Other glycan degradation_Homo sapiens_hsa005110.39711424
113Renal cell carcinoma_Homo sapiens_hsa052110.39556290
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38697999
115Vibrio cholerae infection_Homo sapiens_hsa051100.38332156
116Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.37302982
117Wnt signaling pathway_Homo sapiens_hsa043100.36958077
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36882531
119N-Glycan biosynthesis_Homo sapiens_hsa005100.36420772
120PI3K-Akt signaling pathway_Homo sapiens_hsa041510.35702188
121Glycosaminoglycan degradation_Homo sapiens_hsa005310.34712166
122Hedgehog signaling pathway_Homo sapiens_hsa043400.34255184
123Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33102758
124Toxoplasmosis_Homo sapiens_hsa051450.32162175
125Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.29956048
126Glutathione metabolism_Homo sapiens_hsa004800.29732120
127Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29024043

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