DZIP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.21910311
2vocalization behavior (GO:0071625)5.03816968
3synaptic vesicle maturation (GO:0016188)4.93446549
4locomotory exploration behavior (GO:0035641)4.87717777
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.81922381
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.67105180
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.60857611
8ionotropic glutamate receptor signaling pathway (GO:0035235)4.53880490
9neuron cell-cell adhesion (GO:0007158)4.49650563
10protein localization to synapse (GO:0035418)4.46715201
11layer formation in cerebral cortex (GO:0021819)4.45893652
12dendritic spine morphogenesis (GO:0060997)4.40712514
13synaptic vesicle exocytosis (GO:0016079)4.38349169
14glutamate secretion (GO:0014047)4.38315883
15regulation of glutamate receptor signaling pathway (GO:1900449)4.34580797
16regulation of synaptic vesicle exocytosis (GO:2000300)4.29393747
17exploration behavior (GO:0035640)4.20157563
18synaptic vesicle docking involved in exocytosis (GO:0016081)4.10879386
19neuron recognition (GO:0008038)4.06108759
20glutamate receptor signaling pathway (GO:0007215)3.95382574
21axonal fasciculation (GO:0007413)3.85050895
22neurotransmitter secretion (GO:0007269)3.81815626
23synaptic transmission, glutamatergic (GO:0035249)3.80221483
24regulation of synaptic vesicle transport (GO:1902803)3.74452737
25presynaptic membrane organization (GO:0097090)3.69967755
26regulation of long-term neuronal synaptic plasticity (GO:0048169)3.64936108
27regulation of neuronal synaptic plasticity (GO:0048168)3.62879089
28dendrite morphogenesis (GO:0048813)3.56437620
29cell migration in hindbrain (GO:0021535)3.50042038
30postsynaptic membrane organization (GO:0001941)3.49275176
31central nervous system projection neuron axonogenesis (GO:0021952)3.47738602
32gamma-aminobutyric acid transport (GO:0015812)3.46225391
33regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.45665135
34neuron-neuron synaptic transmission (GO:0007270)3.44019992
35regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.43366336
36regulation of synapse structural plasticity (GO:0051823)3.37435475
37synaptic vesicle endocytosis (GO:0048488)3.32964952
38cilium or flagellum-dependent cell motility (GO:0001539)3.32124742
39neuronal action potential propagation (GO:0019227)3.29872241
40neurotransmitter-gated ion channel clustering (GO:0072578)3.27293211
41proline transport (GO:0015824)3.26781199
42cerebellar Purkinje cell differentiation (GO:0021702)3.25869922
43establishment of nucleus localization (GO:0040023)3.25458356
44regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.23732174
45positive regulation of synaptic transmission, GABAergic (GO:0032230)3.21590923
46long-term memory (GO:0007616)3.21363301
47positive regulation of synapse maturation (GO:0090129)3.13866159
48innervation (GO:0060384)3.13383634
49membrane depolarization during action potential (GO:0086010)3.12034974
50calcium ion-dependent exocytosis (GO:0017156)3.11152314
51neurotransmitter transport (GO:0006836)3.10553696
52membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.09639171
53regulation of dendritic spine morphogenesis (GO:0061001)3.08067636
54regulation of excitatory postsynaptic membrane potential (GO:0060079)3.06491057
55transmission of nerve impulse (GO:0019226)3.06245891
56activation of protein kinase A activity (GO:0034199)3.02332392
57epithelial cilium movement (GO:0003351)3.01814762
58startle response (GO:0001964)3.01733918
59positive regulation of synapse assembly (GO:0051965)3.00369882
60pyrimidine nucleobase catabolic process (GO:0006208)3.00303462
61regulation of postsynaptic membrane potential (GO:0060078)2.96954823
62response to auditory stimulus (GO:0010996)2.96766488
63auditory behavior (GO:0031223)2.95572527
64cellular potassium ion homeostasis (GO:0030007)2.95151492
65sperm motility (GO:0030317)2.94400630
66cerebellar Purkinje cell layer development (GO:0021680)2.93824899
67neuromuscular process controlling balance (GO:0050885)2.93068402
68positive regulation of membrane potential (GO:0045838)2.92532329
69cilium movement (GO:0003341)2.92141719
70sodium ion export (GO:0071436)2.92017263
71regulation of neurotransmitter secretion (GO:0046928)2.91232946
72regulation of respiratory system process (GO:0044065)2.90583322
73acrosome assembly (GO:0001675)2.90203424
74G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.90110287
75dendritic spine organization (GO:0097061)2.89436147
76neuronal ion channel clustering (GO:0045161)2.89174883
77regulation of synaptic transmission, glutamatergic (GO:0051966)2.85477650
78presynaptic membrane assembly (GO:0097105)2.84194378
79synapse assembly (GO:0007416)2.83271597
80cell communication by electrical coupling (GO:0010644)2.81473075
81acrosome reaction (GO:0007340)2.79249450
82vesicle transport along microtubule (GO:0047496)2.78854424
83regulation of synaptic plasticity (GO:0048167)2.77617719
84synapse organization (GO:0050808)2.76661732
85positive regulation of dendritic spine morphogenesis (GO:0061003)2.76039500
86regulation of neurotransmitter levels (GO:0001505)2.75974450
87prepulse inhibition (GO:0060134)2.75870263
88gamma-aminobutyric acid signaling pathway (GO:0007214)2.75147207
89negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.74637070
90neuronal stem cell maintenance (GO:0097150)2.74479067
91behavioral defense response (GO:0002209)2.73469742
92behavioral fear response (GO:0001662)2.73469742
93clathrin coat assembly (GO:0048268)2.73449581
94long-term synaptic potentiation (GO:0060291)2.73155737
95membrane depolarization (GO:0051899)2.72979533
96response to pheromone (GO:0019236)2.71421628
97positive regulation of dendritic spine development (GO:0060999)2.71089278
98nephron epithelium morphogenesis (GO:0072088)2.70882558
99nephron tubule morphogenesis (GO:0072078)2.70882558
100epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.70807010
101axon extension (GO:0048675)2.70485359
102positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.70234390
103positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.69953044
104regulation of vesicle fusion (GO:0031338)2.69352515
105paraxial mesoderm development (GO:0048339)2.68881776
106negative regulation of astrocyte differentiation (GO:0048712)2.68242302
107neuron fate determination (GO:0048664)2.64423712
108axon ensheathment in central nervous system (GO:0032291)2.60904606
109central nervous system myelination (GO:0022010)2.60904606
110limb bud formation (GO:0060174)2.58209841
111artery development (GO:0060840)2.56552078
112spinal cord development (GO:0021510)2.49140989
113appendage development (GO:0048736)2.46988149
114limb development (GO:0060173)2.46988149
115outer ear morphogenesis (GO:0042473)2.45996291
116renal tubule morphogenesis (GO:0061333)2.44651181
117notochord development (GO:0030903)2.42571061
118lateral sprouting from an epithelium (GO:0060601)2.41986675
119neuron projection extension involved in neuron projection guidance (GO:1902284)2.41794942
120axon extension involved in axon guidance (GO:0048846)2.41794942
121cerebral cortex radially oriented cell migration (GO:0021799)2.41681691
122generation of neurons (GO:0048699)2.40949405
123regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.39128804
124nonmotile primary cilium assembly (GO:0035058)2.37551282
125regulation of axon guidance (GO:1902667)2.32829437
126chondrocyte proliferation (GO:0035988)2.31458376
127retinal ganglion cell axon guidance (GO:0031290)2.30541319
128somite development (GO:0061053)2.28469645
129negative regulation of axon guidance (GO:1902668)2.25153083
130negative regulation of oligodendrocyte differentiation (GO:0048715)2.22576245
131regulation of non-canonical Wnt signaling pathway (GO:2000050)2.22241711
132dorsal/ventral axis specification (GO:0009950)2.21116021
133hindbrain development (GO:0030902)2.19810629
134negative chemotaxis (GO:0050919)2.19378580
135regulation of axon extension involved in axon guidance (GO:0048841)2.18146959
136regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.13315401
137regulation of synapse assembly (GO:0051963)2.12998879
138cochlea morphogenesis (GO:0090103)2.12315529
139central nervous system neuron axonogenesis (GO:0021955)2.12266521
140negative regulation of DNA-dependent DNA replication (GO:2000104)2.10773601
141metanephric mesenchyme development (GO:0072075)2.08986814
142smoothened signaling pathway (GO:0007224)2.08662348
143cell-cell signaling involved in cell fate commitment (GO:0045168)2.07408918
144inner ear receptor cell development (GO:0060119)2.06956642
145G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.06655405
146kidney mesenchyme development (GO:0072074)2.06440095
147astrocyte development (GO:0014002)2.06426530
148otic vesicle formation (GO:0030916)2.06203829
149establishment of planar polarity (GO:0001736)2.05687540
150establishment of tissue polarity (GO:0007164)2.05687540
151negative regulation of axon extension (GO:0030517)2.05289188
152negative regulation of glial cell differentiation (GO:0045686)2.05051646
153apical protein localization (GO:0045176)2.04759490
154cranial nerve development (GO:0021545)2.03530753
155cranial nerve morphogenesis (GO:0021602)2.03418570
156protein localization to kinetochore (GO:0034501)2.02416249
157ventricular cardiac muscle cell development (GO:0055015)2.00753294
158centrosome duplication (GO:0051298)2.00220160
159neural crest cell development (GO:0014032)1.99585088
160negative regulation of axon extension involved in axon guidance (GO:0048843)1.98976429
161microtubule polymerization or depolymerization (GO:0031109)1.98762369
162developmental induction (GO:0031128)1.98180139
163microtubule depolymerization (GO:0007019)1.98001273
164thalamus development (GO:0021794)1.97147454
165midbrain development (GO:0030901)1.96808451

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.72352994
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.11718858
3GBX2_23144817_ChIP-Seq_PC3_Human3.08169854
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.67668602
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.63611814
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.55672156
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.47095619
8REST_21632747_ChIP-Seq_MESCs_Mouse2.45075004
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.42304239
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.42304239
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.41694949
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.37594850
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.35850403
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.33393277
15CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.30486874
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.29403111
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.24171635
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.21981800
19DROSHA_22980978_ChIP-Seq_HELA_Human2.20962424
20* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.16422488
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.14288936
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.14192738
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.13052352
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.12937076
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.10363515
26SUZ12_27294783_Chip-Seq_ESCs_Mouse2.09659212
27RARB_27405468_Chip-Seq_BRAIN_Mouse2.01512758
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.93762261
29ZNF274_21170338_ChIP-Seq_K562_Hela1.91235293
30REST_18959480_ChIP-ChIP_MESCs_Mouse1.87106737
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.82081893
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.79975130
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78313089
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.60268220
35EWS_26573619_Chip-Seq_HEK293_Human1.58613258
36* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56482016
37SMAD4_21799915_ChIP-Seq_A2780_Human1.54175039
38TAF15_26573619_Chip-Seq_HEK293_Human1.52918031
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.52766452
40POU5F1_16153702_ChIP-ChIP_HESCs_Human1.52356985
41AR_21572438_ChIP-Seq_LNCaP_Human1.52072358
42RNF2_27304074_Chip-Seq_NSC_Mouse1.51390854
43FOXM1_23109430_ChIP-Seq_U2OS_Human1.50721560
44MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.47358027
45WT1_19549856_ChIP-ChIP_CCG9911_Human1.43504681
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43307964
47* RING1B_27294783_Chip-Seq_ESCs_Mouse1.42051502
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41973743
49MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.40499625
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35917941
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32614861
52HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.31478055
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27699322
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.27071398
55P300_19829295_ChIP-Seq_ESCs_Human1.26006113
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.25903845
57STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.25195709
58RBPJ_22232070_ChIP-Seq_NCS_Mouse1.25070493
59VDR_22108803_ChIP-Seq_LS180_Human1.23112662
60RING1B_27294783_Chip-Seq_NPCs_Mouse1.23104146
61TP63_19390658_ChIP-ChIP_HaCaT_Human1.22786759
62EP300_21415370_ChIP-Seq_HL-1_Mouse1.21897418
63SOX2_21211035_ChIP-Seq_LN229_Gbm1.21061138
64TBX3_20139965_ChIP-Seq_MESCs_Mouse1.19803357
65TBX3_20139965_ChIP-Seq_ESCs_Mouse1.18641750
66ERG_21242973_ChIP-ChIP_JURKAT_Human1.17712827
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17334971
68RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.17324029
69MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.16608649
70POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16455820
71TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16455820
72* AR_25329375_ChIP-Seq_VCAP_Human1.16292430
73* AR_19668381_ChIP-Seq_PC3_Human1.15568172
74* STAT3_23295773_ChIP-Seq_U87_Human1.15437693
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14969520
76ISL1_27105846_Chip-Seq_CPCs_Mouse1.14918728
77LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14891634
78* FUS_26573619_Chip-Seq_HEK293_Human1.14878674
79ZFP281_18757296_ChIP-ChIP_E14_Mouse1.14497056
80RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14348394
81UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13551920
82TP53_18474530_ChIP-ChIP_U2OS_Human1.12888304
83MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12829097
84YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10775135
85TP53_16413492_ChIP-PET_HCT116_Human1.10133025
86IGF1R_20145208_ChIP-Seq_DFB_Human1.09282943
87ARNT_22903824_ChIP-Seq_MCF-7_Human1.09157091
88WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08555538
89WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07933437
90TCF4_23295773_ChIP-Seq_U87_Human1.07399073
91* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06659357
92CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06618337
93TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06481390
94GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04643052
95SMAD3_21741376_ChIP-Seq_ESCs_Human1.04462830
96TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.03152614
97KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.02532464
98CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02395973
99OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02393021
100JUN_21703547_ChIP-Seq_K562_Human1.02050576
101PIAS1_25552417_ChIP-Seq_VCAP_Human1.00018672
102MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.99749959
103BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.99681471
104NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.99198142
105AHR_22903824_ChIP-Seq_MCF-7_Human0.98383512
106P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98113481
107SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.98064270
108CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97801654
109* CBP_20019798_ChIP-Seq_JUKART_Human0.97174692
110* IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97174692
111RUNX2_22187159_ChIP-Seq_PCA_Human0.97015901
112TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97012230
113SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96938289
114AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96680431
115KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.95965444
116* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95788605
117STAT6_21828071_ChIP-Seq_BEAS2B_Human0.95656760
118ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94845749
119* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94817046
120ELK4_26923725_Chip-Seq_MESODERM_Mouse0.94766207
121RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.94516459
122WDR5_24793694_ChIP-Seq_LNCAP_Human0.94508110
123PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94332646
124TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93807717
125CDX2_19796622_ChIP-Seq_MESCs_Mouse0.92369350
126POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91996639
127NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91654137
128GATA1_26923725_Chip-Seq_HPCs_Mouse0.89489190
129* SOX9_26525672_Chip-Seq_HEART_Mouse0.89435983
130EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.89001049

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.43864917
2MP0003880_abnormal_central_pattern4.30327388
3MP0003635_abnormal_synaptic_transmissio3.62569453
4MP0004270_analgesia3.03900981
5MP0005423_abnormal_somatic_nervous2.98445562
6MP0002063_abnormal_learning/memory/cond2.91901506
7MP0009745_abnormal_behavioral_response2.81937863
8MP0009046_muscle_twitch2.64485359
9MP0002064_seizures2.56275234
10MP0001968_abnormal_touch/_nociception2.47772768
11MP0002572_abnormal_emotion/affect_behav2.43861907
12MP0000778_abnormal_nervous_system2.36260835
13MP0005410_abnormal_fertilization2.33630662
14MP0003122_maternal_imprinting2.32269763
15MP0003787_abnormal_imprinting2.28171542
16MP0001486_abnormal_startle_reflex2.24755168
17MP0002734_abnormal_mechanical_nocicepti2.20013029
18MP0003136_yellow_coat_color2.02034857
19MP0002272_abnormal_nervous_system2.00981323
20MP0002184_abnormal_innervation1.98117990
21MP0002736_abnormal_nociception_after1.92202171
22MP0010030_abnormal_orbit_morphology1.90748359
23MP0001440_abnormal_grooming_behavior1.80821583
24MP0000049_abnormal_middle_ear1.78926593
25MP0002735_abnormal_chemical_nociception1.78508927
26MP0002938_white_spotting1.76237001
27MP0009780_abnormal_chondrocyte_physiolo1.75533653
28MP0006276_abnormal_autonomic_nervous1.75419911
29MP0002557_abnormal_social/conspecific_i1.75362322
30MP0006292_abnormal_olfactory_placode1.74087926
31MP0002067_abnormal_sensory_capabilities1.71643656
32MP0004858_abnormal_nervous_system1.71488512
33MP0003937_abnormal_limbs/digits/tail_de1.69436959
34MP0000955_abnormal_spinal_cord1.68968128
35MP0004811_abnormal_neuron_physiology1.66639639
36MP0001501_abnormal_sleep_pattern1.66115896
37MP0001293_anophthalmia1.65864765
38MP0000569_abnormal_digit_pigmentation1.63742662
39MP0002733_abnormal_thermal_nociception1.60831181
40MP0005623_abnormal_meninges_morphology1.57628166
41MP0001970_abnormal_pain_threshold1.51849943
42MP0008569_lethality_at_weaning1.51642859
43MP0004885_abnormal_endolymph1.49373796
44MP0000566_synostosis1.48583850
45MP0003121_genomic_imprinting1.46484896
46MP0002882_abnormal_neuron_morphology1.46074387
47MP0002638_abnormal_pupillary_reflex1.43157067
48MP0002233_abnormal_nose_morphology1.42042999
49MP0003890_abnormal_embryonic-extraembry1.38319209
50MP0001984_abnormal_olfaction1.36897554
51MP0002152_abnormal_brain_morphology1.35924363
52MP0005386_behavior/neurological_phenoty1.35830251
53MP0004924_abnormal_behavior1.35830251
54MP0008877_abnormal_DNA_methylation1.33736619
55MP0003879_abnormal_hair_cell1.32635793
56MP0002697_abnormal_eye_size1.32359151
57MP0002653_abnormal_ependyma_morphology1.29153083
58MP0003283_abnormal_digestive_organ1.29032269
59MP0002909_abnormal_adrenal_gland1.28276538
60MP0008438_abnormal_cutaneous_collagen1.28238803
61MP0003698_abnormal_male_reproductive1.27042120
62MP0004272_abnormal_basement_membrane1.26131921
63MP0001286_abnormal_eye_development1.25860689
64MP0002066_abnormal_motor_capabilities/c1.24963458
65MP0005645_abnormal_hypothalamus_physiol1.24849100
66MP0002822_catalepsy1.22115016
67MP0005499_abnormal_olfactory_system1.18821242
68MP0005394_taste/olfaction_phenotype1.18821242
69MP0003329_amyloid_beta_deposits1.18244152
70MP0009053_abnormal_anal_canal1.18240025
71MP0000428_abnormal_craniofacial_morphol1.17331469
72MP0005646_abnormal_pituitary_gland1.16945870
73MP0002249_abnormal_larynx_morphology1.16747173
74MP0003385_abnormal_body_wall1.15059559
75MP0003123_paternal_imprinting1.14838303
76MP0003861_abnormal_nervous_system1.13943419
77MP0003935_abnormal_craniofacial_develop1.13733678
78MP0005171_absent_coat_pigmentation1.13186284
79MP0001346_abnormal_lacrimal_gland1.09612801
80MP0000631_abnormal_neuroendocrine_gland1.09368841
81MP0009384_cardiac_valve_regurgitation1.08347204
82MP0002282_abnormal_trachea_morphology1.06009117
83MP0000534_abnormal_ureter_morphology1.05885539
84MP0002116_abnormal_craniofacial_bone1.05385141
85MP0001529_abnormal_vocalization1.03429926
86MP0004142_abnormal_muscle_tone1.02464825
87MP0001299_abnormal_eye_distance/0.98794492
88MP0001502_abnormal_circadian_rhythm0.98411293
89MP0000432_abnormal_head_morphology0.97524028
90MP0004233_abnormal_muscle_weight0.97458538
91MP0002102_abnormal_ear_morphology0.95913356
92MP0001188_hyperpigmentation0.95366643
93MP0005391_vision/eye_phenotype0.93654235
94MP0004145_abnormal_muscle_electrophysio0.93390545
95MP0005187_abnormal_penis_morphology0.92968473
96MP0002752_abnormal_somatic_nervous0.92437787
97MP0003942_abnormal_urinary_system0.92205614
98MP0000751_myopathy0.91963895
99MP0002751_abnormal_autonomic_nervous0.91126977
100MP0003941_abnormal_skin_development0.90960829
101MP0000537_abnormal_urethra_morphology0.90788733
102MP0002092_abnormal_eye_morphology0.88854825
103MP0005253_abnormal_eye_physiology0.88564685
104MP0003633_abnormal_nervous_system0.87309423
105MP0005248_abnormal_Harderian_gland0.87279509
106MP0002084_abnormal_developmental_patter0.84706204
107MP0010094_abnormal_chromosome_stability0.83702672
108MP0001177_atelectasis0.83451627
109MP0005551_abnormal_eye_electrophysiolog0.82778087
110MP0005195_abnormal_posterior_eye0.81653696
111MP0002069_abnormal_eating/drinking_beha0.79714249
112MP0004742_abnormal_vestibular_system0.79686180
113MP0003634_abnormal_glial_cell0.79434002
114MP0002085_abnormal_embryonic_tissue0.78872096
115MP0002109_abnormal_limb_morphology0.77849984
116MP0003938_abnormal_ear_development0.77625457
117MP0003631_nervous_system_phenotype0.77555848
118MP0008789_abnormal_olfactory_epithelium0.76675647
119MP0003119_abnormal_digestive_system0.76048162
120MP0001963_abnormal_hearing_physiology0.75341849
121MP0004133_heterotaxia0.75102112
122MP0009250_abnormal_appendicular_skeleto0.73584841
123MP0006072_abnormal_retinal_apoptosis0.72588516
124MP0001929_abnormal_gametogenesis0.72587147
125MP0001905_abnormal_dopamine_level0.71695177
126MP0002081_perinatal_lethality0.71497793
127MP0001485_abnormal_pinna_reflex0.70749433
128MP0002161_abnormal_fertility/fecundity0.70133971
129MP0003755_abnormal_palate_morphology0.69103046
130MP0008961_abnormal_basal_metabolism0.68788870
131MP0001943_abnormal_respiration0.68242077
132MP0000026_abnormal_inner_ear0.68156107
133MP0005503_abnormal_tendon_morphology0.66769392
134MP0003137_abnormal_impulse_conducting0.66613788
135MP0004085_abnormal_heartbeat0.65304550
136MP0002234_abnormal_pharynx_morphology0.64239589

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.36344360
2Dynein arm defect of respiratory motile cilia (HP:0012255)4.52617343
3Absent/shortened dynein arms (HP:0200106)4.52617343
4Focal seizures (HP:0007359)4.44361117
5Myokymia (HP:0002411)4.37938721
6Visual hallucinations (HP:0002367)4.18666763
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.79210152
8Progressive cerebellar ataxia (HP:0002073)3.67958312
9Epileptic encephalopathy (HP:0200134)3.48288805
10Abnormal respiratory motile cilium physiology (HP:0012261)3.27334119
11Absence seizures (HP:0002121)3.23551397
12Atonic seizures (HP:0010819)3.13415133
13Febrile seizures (HP:0002373)3.09030709
14Abnormal respiratory epithelium morphology (HP:0012253)3.02635760
15Abnormal respiratory motile cilium morphology (HP:0005938)3.02635760
16Abnormal ciliary motility (HP:0012262)3.02013126
17Genetic anticipation (HP:0003743)2.85157226
18Abnormality of the lower motor neuron (HP:0002366)2.84273757
19Amyotrophic lateral sclerosis (HP:0007354)2.78895891
20Dialeptic seizures (HP:0011146)2.76308331
21Neonatal short-limb short stature (HP:0008921)2.73295314
22Supranuclear gaze palsy (HP:0000605)2.72550596
23Broad-based gait (HP:0002136)2.61119577
24Mutism (HP:0002300)2.58259446
25Generalized tonic-clonic seizures (HP:0002069)2.57303719
26Drooling (HP:0002307)2.55610049
27Excessive salivation (HP:0003781)2.55610049
28Action tremor (HP:0002345)2.53363605
29Ankle clonus (HP:0011448)2.48957301
30Abnormality of midbrain morphology (HP:0002418)2.41446191
31Molar tooth sign on MRI (HP:0002419)2.41446191
32True hermaphroditism (HP:0010459)2.39144190
33Amblyopia (HP:0000646)2.38146828
34Septo-optic dysplasia (HP:0100842)2.37194334
35Hemiparesis (HP:0001269)2.35247814
36Rhinitis (HP:0012384)2.32760945
37Impaired vibration sensation in the lower limbs (HP:0002166)2.31182059
38Gaze-evoked nystagmus (HP:0000640)2.29129823
39Turricephaly (HP:0000262)2.27826381
40Urinary bladder sphincter dysfunction (HP:0002839)2.27761093
41Depression (HP:0000716)2.25107771
42Pancreatic fibrosis (HP:0100732)2.23508058
43Volvulus (HP:0002580)2.22674621
44Truncal ataxia (HP:0002078)2.22333823
45Aqueductal stenosis (HP:0002410)2.16294763
46Dysdiadochokinesis (HP:0002075)2.14907784
47Urinary urgency (HP:0000012)2.14421892
48Abnormal eating behavior (HP:0100738)2.13834780
49Preaxial foot polydactyly (HP:0001841)2.13370807
50Morphological abnormality of the middle ear (HP:0008609)2.11420937
51Coronal craniosynostosis (HP:0004440)2.07485331
52Postural instability (HP:0002172)2.04561501
53Midline defect of the nose (HP:0004122)2.03868145
54Occipital encephalocele (HP:0002085)2.00330936
55Aplasia/Hypoplasia of the brainstem (HP:0007362)2.00272544
56Hypoplasia of the brainstem (HP:0002365)2.00272544
57Chromosomal breakage induced by crosslinking agents (HP:0003221)1.99822157
58Progressive inability to walk (HP:0002505)1.98661502
59Hyperventilation (HP:0002883)1.98518659
60Abnormality of the ischium (HP:0003174)1.98069857
61Absent speech (HP:0001344)1.97840070
62Impaired smooth pursuit (HP:0007772)1.97374234
63Poor eye contact (HP:0000817)1.96640089
64Bifid tongue (HP:0010297)1.96390104
65Limb dystonia (HP:0002451)1.95508555
66Cutaneous syndactyly (HP:0012725)1.95283893
67Chromsome breakage (HP:0040012)1.95278697
68Infertility (HP:0000789)1.94026946
69Abnormality of ocular smooth pursuit (HP:0000617)1.93712431
70Broad metatarsal (HP:0001783)1.93355752
71Megalencephaly (HP:0001355)1.93032470
72Narrow nasal bridge (HP:0000446)1.92011998
73Polyphagia (HP:0002591)1.91434786
74Neoplasm of the heart (HP:0100544)1.90893601
75Pointed chin (HP:0000307)1.90299263
76Anophthalmia (HP:0000528)1.88817552
77Hepatoblastoma (HP:0002884)1.88614995
78Optic nerve hypoplasia (HP:0000609)1.87632542
79Agitation (HP:0000713)1.87182578
80Gait imbalance (HP:0002141)1.87053117
81Shallow orbits (HP:0000586)1.86257419
82Hypoventilation (HP:0002791)1.86191181
83Intestinal atresia (HP:0011100)1.85243559
84Renal duplication (HP:0000075)1.84582845
85Insomnia (HP:0100785)1.84102623
86Shawl scrotum (HP:0000049)1.83502500
87Dysmetria (HP:0001310)1.83290980
88Hemiplegia (HP:0002301)1.81196639
89Abnormal number of incisors (HP:0011064)1.80613042
90Inappropriate behavior (HP:0000719)1.80336947
91Gastrointestinal atresia (HP:0002589)1.80192921
92Abnormality of the corticospinal tract (HP:0002492)1.78937441
93Esophageal atresia (HP:0002032)1.78632707
94Pancreatic cysts (HP:0001737)1.77294105
95Abnormal social behavior (HP:0012433)1.77135470
96Impaired social interactions (HP:0000735)1.77135470
97Cystic liver disease (HP:0006706)1.76957401
98Nephronophthisis (HP:0000090)1.76898505
99Spastic gait (HP:0002064)1.76085207
100Chronic hepatic failure (HP:0100626)1.75754410
101Bronchomalacia (HP:0002780)1.73708848
102Hypoplastic ischia (HP:0003175)1.73403861
103Insidious onset (HP:0003587)1.73318098
104Termporal pattern (HP:0011008)1.73318098
105Diplopia (HP:0000651)1.72936367
106Abnormality of binocular vision (HP:0011514)1.72936367
107Torticollis (HP:0000473)1.72349842
108Cerebral inclusion bodies (HP:0100314)1.71820652
109Abnormality of dentin (HP:0010299)1.71285640
110Anxiety (HP:0000739)1.71068189
111Sacral dimple (HP:0000960)1.70679629
112Blue irides (HP:0000635)1.69566112
113Specific learning disability (HP:0001328)1.69429847
114Papilledema (HP:0001085)1.69191821
115Postaxial hand polydactyly (HP:0001162)1.68135519
116Lissencephaly (HP:0001339)1.67957699
117Lower limb muscle weakness (HP:0007340)1.67411990
118Genital tract atresia (HP:0001827)1.66596782
119Morphological abnormality of the inner ear (HP:0011390)1.66175030
120Abnormality of the labia minora (HP:0012880)1.65343520
121Wide anterior fontanel (HP:0000260)1.65218541
122Aplasia/Hypoplasia of the sternum (HP:0006714)1.63269144
123Meckel diverticulum (HP:0002245)1.62819051
124Vaginal atresia (HP:0000148)1.62590346
125Soft skin (HP:0000977)1.62497510
126Microglossia (HP:0000171)1.62101881
127Postaxial foot polydactyly (HP:0001830)1.62032613
128Preaxial hand polydactyly (HP:0001177)1.61973287
129Generalized hypotonia (HP:0001290)1.61909426
130Neurofibrillary tangles (HP:0002185)1.61581699
131Shoulder girdle muscle weakness (HP:0003547)1.60617554
132Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.60188623
133Stereotypic behavior (HP:0000733)1.59816257
134Abnormality of the renal medulla (HP:0100957)1.59233172
135Epileptiform EEG discharges (HP:0011182)1.58949039
136Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.58851988
137Chronic bronchitis (HP:0004469)1.58777985
138Colon cancer (HP:0003003)1.58602160
139Supernumerary spleens (HP:0009799)1.58390889
140Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.58369608
141Short 4th metacarpal (HP:0010044)1.58369608
142Cutaneous finger syndactyly (HP:0010554)1.57094430
143Abnormality of the astrocytes (HP:0100707)1.57035141
144Astrocytoma (HP:0009592)1.57035141
145Medial flaring of the eyebrow (HP:0010747)1.56950910
146Aplasia/Hypoplasia of the uvula (HP:0010293)1.56842057
147Exotropia (HP:0000577)1.56835620
148Abnormality of the middle phalanges of the toes (HP:0010183)1.56681313
149Fetal akinesia sequence (HP:0001989)1.56590660
150Aplasia involving bones of the upper limbs (HP:0009823)1.55013939
151Aplasia of the phalanges of the hand (HP:0009802)1.55013939
152Aplasia involving bones of the extremities (HP:0009825)1.55013939
153Oligodactyly (hands) (HP:0001180)1.54521599
154Abnormality of the ileum (HP:0001549)1.54393741
155Anencephaly (HP:0002323)1.54331547
156Sclerocornea (HP:0000647)1.53472497
157Missing ribs (HP:0000921)1.53097219
158Renal hypoplasia (HP:0000089)1.50971729
159Tubular atrophy (HP:0000092)1.49714119
160Omphalocele (HP:0001539)1.49305968
161Renal dysplasia (HP:0000110)1.48255366
162Bilateral microphthalmos (HP:0007633)1.47248123
163Hypoplastic iliac wings (HP:0002866)1.46829556
164Fibular hypoplasia (HP:0003038)1.46116336
165Premature rupture of membranes (HP:0001788)1.45846764
166Narrow forehead (HP:0000341)1.45232425
167Congenital primary aphakia (HP:0007707)1.45045422
168Partial duplication of the phalanx of hand (HP:0009999)1.44111299
169Mild short stature (HP:0003502)1.43384342
170Protruding tongue (HP:0010808)1.43337956
171Protrusio acetabuli (HP:0003179)1.42434343
172Limited hip movement (HP:0008800)1.41941319
173Broad long bones (HP:0005622)1.41601385
174Trigonocephaly (HP:0000243)1.40940114
175Micropenis (HP:0000054)1.40319733
176Tracheomalacia (HP:0002779)1.39797722

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.52878857
2NTRK34.00997500
3WEE13.16391059
4MAP3K93.10849424
5MAP3K43.09751995
6EPHA42.99908445
7NTRK22.85785078
8PRKD32.63782206
9MINK12.62317049
10MAP2K72.37131504
11PNCK2.29724683
12MKNK22.19008968
13PAK62.07364315
14MAP3K122.03353472
15FRK2.01521839
16MAPK131.95263507
17CASK1.84487576
18MAP2K41.77952432
19TSSK61.77103920
20TYRO31.74305557
21LATS21.63449295
22SIK21.60337364
23KSR11.58716540
24PDK41.54859954
25PDK31.54859954
26ICK1.51058736
27STK381.50995421
28DAPK21.45440454
29PLK21.44927372
30MKNK11.43359204
31IRAK11.40162283
32CAMKK11.40032924
33PLK31.33698650
34CDK51.31993428
35UHMK11.25040879
36CDC71.24253175
37PRPF4B1.23439139
38ERBB31.19812074
39PHKG21.19100729
40PHKG11.19100729
41BMPR1B1.18951196
42PRKCG1.15310907
43BRSK21.12375790
44NTRK11.09797926
45AKT31.06543925
46PAK31.06542343
47PLK41.05448004
48TNIK1.04770067
49LATS11.03597682
50STK38L1.01960030
51STK31.01548230
52MAPK151.00431034
53CDK181.00053375
54BUB10.99921667
55CAMK1G0.99567921
56CSNK1G20.97552034
57WNK10.97538852
58CDK150.97218606
59GRK50.96785769
60FGFR20.92909081
61CDK140.91940840
62BRSK10.91621872
63MARK20.88337792
64TTK0.87824603
65PTK2B0.86179054
66KSR20.85105564
67CDK11A0.84256236
68DDR20.83390345
69PRKCH0.82918704
70DAPK10.81654042
71PLK10.80462406
72TESK10.80401346
73CAMK2A0.79990432
74PDGFRA0.78648247
75CAMK1D0.77733171
76CSNK1G10.77632069
77ALK0.77622729
78STK110.77436214
79CDK30.75181711
80STK390.74771002
81DYRK1A0.74486369
82TAOK10.73017400
83LMTK20.72796722
84ZAK0.71999866
85TAF10.71321742
86RET0.69919082
87DYRK20.69785349
88CHEK20.69756579
89SGK4940.69227818
90SGK2230.69227818
91NUAK10.66863113
92SGK20.66767182
93CDC42BPA0.66585625
94NEK20.66066127
95BRD40.65415116
96PAK20.65023254
97ERBB20.63164276
98WNK40.62667777
99CDK120.60963260
100FER0.60181400
101PDK20.58679054
102SGK10.58604053
103MAPKAPK50.56755948
104RIPK40.56329197
105CDK190.55343173
106CAMK2B0.54651841
107MAPK100.54554305
108TIE10.53925167
109SGK30.53395886
110CAMK10.53285604
111FES0.52633421
112INSRR0.52476459
113SRPK10.52271821
114PINK10.50619251
115CSNK1A1L0.50464456
116PRKCZ0.50202372
117RPS6KA20.50002861
118CSNK1G30.48975204
119WNK30.48216719
120RPS6KA30.47880619
121ATM0.47865886
122LIMK10.47467711
123PRKDC0.46326614
124EPHB20.45835208
125BCR0.45157345
126FGFR10.44867500
127ATR0.43562175
128SIK30.41487525
129TRIM280.41376835
130CHEK10.41273719
131MELK0.40822988
132ROCK20.40250076
133DMPK0.40139065
134ROCK10.39951266
135VRK10.39714008
136CDK10.39409306
137FYN0.38564143
138RIPK10.37857776
139GSK3B0.36756749
140CSNK1E0.36610833
141PRKCE0.36354781
142MAPK80.35902476
143PRKCB0.34898699
144CAMKK20.34814106
145PKN10.34088161
146CAMK40.32104896
147MAPK90.31727532

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.71285551
2Synaptic vesicle cycle_Homo sapiens_hsa047212.77794907
3Circadian entrainment_Homo sapiens_hsa047132.52237453
4Long-term potentiation_Homo sapiens_hsa047202.50223825
5GABAergic synapse_Homo sapiens_hsa047272.49118950
6Glutamatergic synapse_Homo sapiens_hsa047242.48303592
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.36649479
8Amphetamine addiction_Homo sapiens_hsa050312.32433303
9Olfactory transduction_Homo sapiens_hsa047402.27342244
10Morphine addiction_Homo sapiens_hsa050322.20995948
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.13369639
12Dopaminergic synapse_Homo sapiens_hsa047282.05726840
13Salivary secretion_Homo sapiens_hsa049701.84564107
14Axon guidance_Homo sapiens_hsa043601.76979855
15Insulin secretion_Homo sapiens_hsa049111.76634873
16Taste transduction_Homo sapiens_hsa047421.71118588
17Cocaine addiction_Homo sapiens_hsa050301.70974135
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.66507272
19Gastric acid secretion_Homo sapiens_hsa049711.66195495
20Cholinergic synapse_Homo sapiens_hsa047251.65338611
21Renin secretion_Homo sapiens_hsa049241.63113552
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.60123923
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.58824624
24Long-term depression_Homo sapiens_hsa047301.58282069
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.54097311
26Oxytocin signaling pathway_Homo sapiens_hsa049211.52780674
27Protein export_Homo sapiens_hsa030601.52063656
28Serotonergic synapse_Homo sapiens_hsa047261.46171568
29Calcium signaling pathway_Homo sapiens_hsa040201.44640874
30ECM-receptor interaction_Homo sapiens_hsa045121.42993604
31TGF-beta signaling pathway_Homo sapiens_hsa043501.41793982
32GnRH signaling pathway_Homo sapiens_hsa049121.41237620
33Gap junction_Homo sapiens_hsa045401.40125708
34Fanconi anemia pathway_Homo sapiens_hsa034601.37506117
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.34488983
36Cell cycle_Homo sapiens_hsa041101.34211209
37Oocyte meiosis_Homo sapiens_hsa041141.27878658
38Estrogen signaling pathway_Homo sapiens_hsa049151.27863026
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.27550020
40Melanogenesis_Homo sapiens_hsa049161.27231339
41Non-homologous end-joining_Homo sapiens_hsa034501.25068924
42ErbB signaling pathway_Homo sapiens_hsa040121.21900785
43cAMP signaling pathway_Homo sapiens_hsa040241.21163690
44Glioma_Homo sapiens_hsa052141.20024725
45Dorso-ventral axis formation_Homo sapiens_hsa043201.16334534
46Butanoate metabolism_Homo sapiens_hsa006501.12305036
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.11937900
48Homologous recombination_Homo sapiens_hsa034401.07884029
49Type II diabetes mellitus_Homo sapiens_hsa049301.07878049
50Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05701176
51Protein digestion and absorption_Homo sapiens_hsa049741.03116176
52Vitamin B6 metabolism_Homo sapiens_hsa007501.02675760
53Hedgehog signaling pathway_Homo sapiens_hsa043401.01221480
54Wnt signaling pathway_Homo sapiens_hsa043101.00773960
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00666029
56Basal transcription factors_Homo sapiens_hsa030221.00489402
57Maturity onset diabetes of the young_Homo sapiens_hsa049501.00410289
58cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98952031
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97787572
60Cardiac muscle contraction_Homo sapiens_hsa042600.96931502
61MicroRNAs in cancer_Homo sapiens_hsa052060.94761180
62Endometrial cancer_Homo sapiens_hsa052130.93871084
63Adherens junction_Homo sapiens_hsa045200.93116648
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.92392851
65Basal cell carcinoma_Homo sapiens_hsa052170.91614363
66One carbon pool by folate_Homo sapiens_hsa006700.91242872
67MAPK signaling pathway_Homo sapiens_hsa040100.88748087
68Melanoma_Homo sapiens_hsa052180.88635484
69Collecting duct acid secretion_Homo sapiens_hsa049660.88259954
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.86041647
71RNA polymerase_Homo sapiens_hsa030200.85162393
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.83888164
73Dilated cardiomyopathy_Homo sapiens_hsa054140.83760235
74Lysine degradation_Homo sapiens_hsa003100.83009173
75Fatty acid biosynthesis_Homo sapiens_hsa000610.82549599
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.82342810
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81281170
78Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.81159174
79Choline metabolism in cancer_Homo sapiens_hsa052310.80804928
80Phototransduction_Homo sapiens_hsa047440.78162492
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77338969
82Colorectal cancer_Homo sapiens_hsa052100.77055895
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.75767481
84Glucagon signaling pathway_Homo sapiens_hsa049220.73163440
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72949485
86Hippo signaling pathway_Homo sapiens_hsa043900.72620627
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72349062
88Thyroid hormone synthesis_Homo sapiens_hsa049180.71100783
89Ras signaling pathway_Homo sapiens_hsa040140.70155289
90Vibrio cholerae infection_Homo sapiens_hsa051100.70060707
91Alcoholism_Homo sapiens_hsa050340.69810759
92RNA transport_Homo sapiens_hsa030130.68235814
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68212739
94mTOR signaling pathway_Homo sapiens_hsa041500.67780637
95Rap1 signaling pathway_Homo sapiens_hsa040150.67606687
96VEGF signaling pathway_Homo sapiens_hsa043700.67385229
97Nitrogen metabolism_Homo sapiens_hsa009100.66673653
98Selenocompound metabolism_Homo sapiens_hsa004500.65805945
99Focal adhesion_Homo sapiens_hsa045100.65704319
100Renal cell carcinoma_Homo sapiens_hsa052110.63770152
101Propanoate metabolism_Homo sapiens_hsa006400.62921155
102Steroid biosynthesis_Homo sapiens_hsa001000.62780038
103Pancreatic secretion_Homo sapiens_hsa049720.62536246
104RNA degradation_Homo sapiens_hsa030180.61997750
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61653303
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61511969
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61130830
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59951282
109Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58572034
110Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58254064
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57014072
112ABC transporters_Homo sapiens_hsa020100.56831957
113Pathways in cancer_Homo sapiens_hsa052000.54064549
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53911947
115Endocytosis_Homo sapiens_hsa041440.53305576
116Insulin signaling pathway_Homo sapiens_hsa049100.51953020
117PI3K-Akt signaling pathway_Homo sapiens_hsa041510.50680347
118Non-small cell lung cancer_Homo sapiens_hsa052230.50664410
119Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.49346474
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48597253
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48193760
122Mismatch repair_Homo sapiens_hsa034300.47697353
123Spliceosome_Homo sapiens_hsa030400.45305008
124mRNA surveillance pathway_Homo sapiens_hsa030150.45219723
125Inositol phosphate metabolism_Homo sapiens_hsa005620.43056389
126Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.40463425
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.40132910
128Tight junction_Homo sapiens_hsa045300.39998762
129T cell receptor signaling pathway_Homo sapiens_hsa046600.39035206
130Circadian rhythm_Homo sapiens_hsa047100.37816551
131Ovarian steroidogenesis_Homo sapiens_hsa049130.37665406
132Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37399362
133Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36649902
134Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35822787
135Proteoglycans in cancer_Homo sapiens_hsa052050.34995742
136Central carbon metabolism in cancer_Homo sapiens_hsa052300.33518843

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