DYRK3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of vitamin D biosynthetic process (GO:0060556)5.39702877
2protoporphyrinogen IX metabolic process (GO:0046501)4.53857497
3DNA replication initiation (GO:0006270)4.37091082
4DNA replication-dependent nucleosome assembly (GO:0006335)4.23902829
5DNA replication-dependent nucleosome organization (GO:0034723)4.23902829
6regulation of vitamin metabolic process (GO:0030656)4.16261765
7binding of sperm to zona pellucida (GO:0007339)4.16237343
8sperm-egg recognition (GO:0035036)4.15914630
9protein localization to chromosome, centromeric region (GO:0071459)4.15443185
10fusion of sperm to egg plasma membrane (GO:0007342)4.15390915
11cell adhesion mediated by integrin (GO:0033627)4.14476901
12positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)4.14090534
13regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.07831590
14DNA strand elongation involved in DNA replication (GO:0006271)4.05027623
15positive regulation of chemokine biosynthetic process (GO:0045080)3.99231203
16positive regulation of p38MAPK cascade (GO:1900745)3.98707024
17protein localization to kinetochore (GO:0034501)3.96262938
18protoporphyrinogen IX biosynthetic process (GO:0006782)3.92197935
19DNA deamination (GO:0045006)3.88296695
20sperm motility (GO:0030317)3.87483445
21regulation of histone H3-K9 methylation (GO:0051570)3.86504515
22DNA strand elongation (GO:0022616)3.86117076
23pore complex assembly (GO:0046931)3.85916330
24formation of translation preinitiation complex (GO:0001731)3.76086275
25DNA unwinding involved in DNA replication (GO:0006268)3.74926818
26cellular response to arsenic-containing substance (GO:0071243)3.71768665
27maturation of SSU-rRNA (GO:0030490)3.68967720
28nucleobase biosynthetic process (GO:0046112)3.68918781
29ribosomal small subunit assembly (GO:0000028)3.67843988
30stress fiber assembly (GO:0043149)3.66636421
31telomere maintenance via semi-conservative replication (GO:0032201)3.66163203
32nuclear pore organization (GO:0006999)3.65775832
33mitotic metaphase plate congression (GO:0007080)3.65455002
34piRNA metabolic process (GO:0034587)3.65262862
35cell-cell recognition (GO:0009988)3.65157965
36cilium or flagellum-dependent cell motility (GO:0001539)3.63558548
37DNA replication checkpoint (GO:0000076)3.61569023
38purine nucleobase biosynthetic process (GO:0009113)3.59095293
39synaptonemal complex assembly (GO:0007130)3.57921771
40regulation of mitotic spindle organization (GO:0060236)3.56598800
41folic acid-containing compound biosynthetic process (GO:0009396)3.54317364
42mitotic nuclear envelope disassembly (GO:0007077)3.53664215
43axonemal dynein complex assembly (GO:0070286)3.52794890
44microtubule depolymerization (GO:0007019)3.51678687
45histone exchange (GO:0043486)3.51612833
46chromatin remodeling at centromere (GO:0031055)3.51254667
47spermatid development (GO:0007286)3.50466531
48cell wall macromolecule metabolic process (GO:0044036)3.48839697
49cell wall macromolecule catabolic process (GO:0016998)3.48839697
50mitotic chromosome condensation (GO:0007076)3.48673201
51synaptonemal complex organization (GO:0070193)3.48662619
52regulation of membrane protein ectodomain proteolysis (GO:0051043)3.48096660
53regulation of chemokine biosynthetic process (GO:0045073)3.46792697
54negative regulation of nitric oxide biosynthetic process (GO:0045019)3.43819874
55nuclear pore complex assembly (GO:0051292)3.42686773
56motile cilium assembly (GO:0044458)3.40760280
57positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.40461546
58epithelial cilium movement (GO:0003351)3.38461459
59COPI coating of Golgi vesicle (GO:0048205)3.38114787
60Golgi transport vesicle coating (GO:0048200)3.38114787
61regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.36839272
62ribosome biogenesis (GO:0042254)3.35301332
63CENP-A containing nucleosome assembly (GO:0034080)3.34968828
64protein K6-linked ubiquitination (GO:0085020)3.34945245
65regulation of T-helper 1 cell differentiation (GO:0045625)3.33834229
66regulation of nucleobase-containing compound transport (GO:0032239)3.33268240
67adhesion of symbiont to host cell (GO:0044650)3.33059953
68virion attachment to host cell (GO:0019062)3.33059953
69acrosome assembly (GO:0001675)3.31303138
70nuclear envelope disassembly (GO:0051081)3.31262731
71membrane disassembly (GO:0030397)3.31262731
72regulation of cilium movement (GO:0003352)3.30701677
73mitotic cytokinesis (GO:0000281)3.30019598
74embryonic process involved in female pregnancy (GO:0060136)3.29572638
75DNA replication-independent nucleosome assembly (GO:0006336)3.28305382
76DNA replication-independent nucleosome organization (GO:0034724)3.28305382
77IMP biosynthetic process (GO:0006188)3.28099836
78mitotic sister chromatid cohesion (GO:0007064)3.27401560
79telomere maintenance via recombination (GO:0000722)3.27316240
80male meiosis (GO:0007140)3.24644223
81cytokinetic process (GO:0032506)3.22590231
82somatic hypermutation of immunoglobulin genes (GO:0016446)3.20960414
83somatic diversification of immune receptors via somatic mutation (GO:0002566)3.20960414
84ribonucleoprotein complex biogenesis (GO:0022613)3.19920106
85chaperone-mediated protein complex assembly (GO:0051131)3.19838906
86regulation of fever generation (GO:0031620)3.19584506
87cytoskeleton-dependent cytokinesis (GO:0061640)3.19276162
88trophoblast giant cell differentiation (GO:0060707)3.17505927
89viral transcription (GO:0019083)3.15457743
90metaphase plate congression (GO:0051310)3.14623562
91mitotic sister chromatid segregation (GO:0000070)3.14233609
92translational termination (GO:0006415)3.14211055
93skin morphogenesis (GO:0043589)3.13403121
94translesion synthesis (GO:0019985)3.13328899
95regulation of podosome assembly (GO:0071801)3.12942334
96low-density lipoprotein particle clearance (GO:0034383)3.12533187
97regulation of chronic inflammatory response (GO:0002676)3.10274168
98mitotic recombination (GO:0006312)3.08590739
99spliceosomal snRNP assembly (GO:0000387)3.08047995
100regulation of nitric oxide biosynthetic process (GO:0045428)3.07779623
101positive regulation of heat generation (GO:0031652)3.06865607
102meiotic nuclear division (GO:0007126)3.06589184
103regulation of RNA export from nucleus (GO:0046831)3.05843440
104hemoglobin metabolic process (GO:0020027)3.04613112
105activation of MAPKKK activity (GO:0000185)3.04603448
106ribosomal large subunit biogenesis (GO:0042273)3.04301573
107chromosome condensation (GO:0030261)3.03339388
108response to arsenic-containing substance (GO:0046685)3.03322063
109telomere maintenance via telomere lengthening (GO:0010833)3.03289940
110negative regulation of histone methylation (GO:0031061)3.01907602
111translational initiation (GO:0006413)3.01250089
112decidualization (GO:0046697)3.00854896
113regulation of cytokine secretion involved in immune response (GO:0002739)3.00773658
114ribosomal small subunit biogenesis (GO:0042274)3.00489307
115histone H2A acetylation (GO:0043968)2.99295619
116cellular response to thyroid hormone stimulus (GO:0097067)2.98913731
117plasma membrane fusion (GO:0045026)2.98888124
118acrosome reaction (GO:0007340)2.98850940
119positive regulation of nitric oxide biosynthetic process (GO:0045429)2.98335509
120regulation of posttranscriptional gene silencing (GO:0060147)2.97488136
121regulation of gene silencing by miRNA (GO:0060964)2.97488136
122regulation of gene silencing by RNA (GO:0060966)2.97488136
123multicellular organism reproduction (GO:0032504)2.95606086
124translational elongation (GO:0006414)2.95496358
125positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.95449098
126adhesion of symbiont to host (GO:0044406)2.94326096
127mismatch repair (GO:0006298)2.94317479
128regulation of nuclear cell cycle DNA replication (GO:0033262)2.93864765
129IMP metabolic process (GO:0046040)2.93510448
130iron ion import (GO:0097286)2.92633188
131chromatin assembly or disassembly (GO:0006333)2.92010014
132protein localization to chromosome (GO:0034502)2.91879600
133rRNA processing (GO:0006364)2.91595002
134protein localization to endosome (GO:0036010)2.90604029
135DNA packaging (GO:0006323)2.89335924
136negative regulation of lipid storage (GO:0010888)2.89335509
137postreplication repair (GO:0006301)2.89310598
138negative regulation of erythrocyte differentiation (GO:0045647)2.87452789
139male meiosis I (GO:0007141)2.87229309
140rRNA metabolic process (GO:0016072)2.87047641
141regulation of centriole replication (GO:0046599)2.87040521
142DNA duplex unwinding (GO:0032508)2.86953104
143kinetochore organization (GO:0051383)2.86898565
144branching involved in labyrinthine layer morphogenesis (GO:0060670)2.86811554
145DNA geometric change (GO:0032392)2.86659554
146chromosome organization involved in meiosis (GO:0070192)2.86432230
147nucleotide-excision repair, DNA gap filling (GO:0006297)2.86394372
148intra-S DNA damage checkpoint (GO:0031573)2.85629932
149meiosis I (GO:0007127)2.83753782
150regulation of centrosome cycle (GO:0046605)2.82678219
151epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.82403137
152natural killer cell mediated immunity (GO:0002228)2.80991827
153natural killer cell mediated cytotoxicity (GO:0042267)2.80991827
154positive regulation of DNA-templated transcription, elongation (GO:0032786)2.79511858
155regulation of protein import into nucleus, translocation (GO:0033158)2.74632221
156cellular protein complex localization (GO:0034629)2.72151626
157response to thyroid hormone (GO:0097066)2.71921831
158porphyrin-containing compound biosynthetic process (GO:0006779)2.71588039
159glycosphingolipid catabolic process (GO:0046479)2.69288160
160apoptotic DNA fragmentation (GO:0006309)2.64942486
161sister chromatid segregation (GO:0000819)2.64057791
162regulation of response to osmotic stress (GO:0047484)2.62276692
163regulation of NFAT protein import into nucleus (GO:0051532)2.61596772
164hyaluronan catabolic process (GO:0030214)2.61527090
165maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.55799312
166erythrocyte development (GO:0048821)2.53240442
167positive regulation of protein import into nucleus, translocation (GO:0033160)2.53023055
168oligosaccharide catabolic process (GO:0009313)2.52964633
169lipopolysaccharide-mediated signaling pathway (GO:0031663)2.50958631
170protein retention in ER lumen (GO:0006621)2.48764237
171protein complex localization (GO:0031503)2.48326663
172regulation of spindle organization (GO:0090224)2.47423780
173heme biosynthetic process (GO:0006783)2.42347026
174cellular response to interferon-alpha (GO:0035457)2.41384457
175hemidesmosome assembly (GO:0031581)2.40263117
176regulation of mononuclear cell migration (GO:0071675)2.38985433
177ovulation from ovarian follicle (GO:0001542)2.38214331
178regulation of double-strand break repair (GO:2000779)2.36172137
179sphingosine metabolic process (GO:0006670)2.35273761
180negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.34740182
181porphyrin-containing compound metabolic process (GO:0006778)2.34454190
182positive regulation of natural killer cell activation (GO:0032816)2.34289376
183heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.34252185
184regulation of double-strand break repair via homologous recombination (GO:0010569)2.32062287
185negative regulation of anoikis (GO:2000811)2.30645595
186coronary vasculature morphogenesis (GO:0060977)2.30117791
187substrate-dependent cell migration (GO:0006929)2.29971159
188glycolipid catabolic process (GO:0019377)2.29889876
189regulation of transcription elongation from RNA polymerase II promoter (GO:0034243)2.29400682
190positive regulation of histone acetylation (GO:0035066)2.29384319
191positive regulation of megakaryocyte differentiation (GO:0045654)2.29099760

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.24902810
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.51786600
3GATA1_22025678_ChIP-Seq_K562_Human4.00616880
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.99797282
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.60176531
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.53873338
7* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.51140331
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.30360439
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.29037993
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.12063325
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.95281650
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.90803172
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.72927908
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.72484401
15WT1_19549856_ChIP-ChIP_CCG9911_Human2.44587110
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.40892215
17* GATA1_19941826_ChIP-Seq_K562_Human2.39163458
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.37949902
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.35686433
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.27728495
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.20390082
22GABP_17652178_ChIP-ChIP_JURKAT_Human2.20275913
23SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.19275411
24STAT6_21828071_ChIP-Seq_BEAS2B_Human2.19090477
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.16309545
26XRN2_22483619_ChIP-Seq_HELA_Human2.15214581
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.15200996
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.14812084
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.11762936
30CREB1_15753290_ChIP-ChIP_HEK293T_Human2.07908343
31CLOCK_20551151_ChIP-Seq_293T_Human2.05582459
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.04314763
33TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.02136025
34VDR_23849224_ChIP-Seq_CD4+_Human1.97771794
35SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.96687513
36SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.94762177
37* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.93899128
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.91605882
39* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.90762332
40MYB_21317192_ChIP-Seq_ERMYB_Mouse1.86930183
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.86263704
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.85020789
43ELK3_25401928_ChIP-Seq_HUVEC_Human1.84603846
44* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.80935861
45STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.80227335
46EGR1_19374776_ChIP-ChIP_THP-1_Human1.76748821
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.76691928
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.76055144
49E2F1_18555785_ChIP-Seq_MESCs_Mouse1.75913599
50* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.75528777
51* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.73453655
52UBF1/2_26484160_Chip-Seq_HMECs_Human1.72134957
53SMAD_19615063_ChIP-ChIP_OVARY_Human1.71659922
54FOXP3_21729870_ChIP-Seq_TREG_Human1.70994375
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.69630069
56GABP_19822575_ChIP-Seq_HepG2_Human1.67043079
57* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.66837722
58STAT3_1855785_ChIP-Seq_MESCs_Mouse1.66364018
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.65990738
60SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.65908423
61SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.65908423
62DCP1A_22483619_ChIP-Seq_HELA_Human1.65748051
63HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.62595168
64AR_21909140_ChIP-Seq_LNCAP_Human1.61209135
65* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.60502944
66* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.60489034
67* TTF2_22483619_ChIP-Seq_HELA_Human1.59281534
68RARG_19884340_ChIP-ChIP_MEFs_Mouse1.58915778
69BRD4_25478319_ChIP-Seq_HGPS_Human1.58781620
70THAP11_20581084_ChIP-Seq_MESCs_Mouse1.57490865
71TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.56853790
72KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.55449196
73* NCOR1_26117541_ChIP-Seq_K562_Human1.52799800
74E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.51860364
75SOX2_18555785_ChIP-Seq_MESCs_Mouse1.51529302
76Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.51114987
77POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.50338485
78CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.49379754
79JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.48296156
80PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48138675
81ELF1_17652178_ChIP-ChIP_JURKAT_Human1.46328811
82RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.46328384
83RBPJ_22232070_ChIP-Seq_NCS_Mouse1.45903501
84PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.43883926
85HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.41881459
86* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.41731312
87ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41439882
88* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.40981940
89GATA2_19941826_ChIP-Seq_K562_Human1.39928938
90* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.39858381
91MYC_22102868_ChIP-Seq_BL_Human1.37435872
92* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.36873597
93P300_27058665_Chip-Seq_ZR-75-30cells_Human1.35800030
94ATF3_27146783_Chip-Seq_COLON_Human1.35282176
95KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.34935337
96JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34623272
97* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.34143651
98TRIM28_21343339_ChIP-Seq_HEK293_Human1.30125494
99NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.28457854
100KDM5A_27292631_Chip-Seq_BREAST_Human1.28373702
101CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27939117
102FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.26687863
103GATA2_21666600_ChIP-Seq_HMVEC_Human1.24666644
104* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.23642683
105SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.23622964
106YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20919978
107CIITA_25753668_ChIP-Seq_RAJI_Human1.20842017
108* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.20655188
109* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.17568852
110HIF1A_21447827_ChIP-Seq_MCF-7_Human1.17526092
111DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16784124
112CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.16262972
113EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.16223705
114* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15939959
115* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.15871067
116SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.15698260
117GATA4_21415370_ChIP-Seq_HL-1_Mouse1.14099204
118FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.14006579
119FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.12771357
120SRF_21415370_ChIP-Seq_HL-1_Mouse1.11844227
121NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.09553209
122FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.09483524
123TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08737663
124IRF8_27001747_Chip-Seq_BMDM_Mouse1.08461213
125ZNF263_19887448_ChIP-Seq_K562_Human1.08299339
126ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07998806
127SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06817076
128TP63_19390658_ChIP-ChIP_HaCaT_Human1.06808165
129STAT4_19710469_ChIP-ChIP_TH1__Mouse1.06372092
130ELK1_19687146_ChIP-ChIP_HELA_Human1.06061748
131SCL_19346495_ChIP-Seq_HPC-7_Human1.05840296
132IRF8_22096565_ChIP-ChIP_GC-B_Human1.05167614
133GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04522402
134CJUN_26792858_Chip-Seq_BT549_Human1.03733281
135* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03476485
136NANOG_21062744_ChIP-ChIP_HESCs_Human1.03388142
137TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.03286886
138TFEB_21752829_ChIP-Seq_HELA_Human1.02384197
139KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.00787357
140KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.00787357
141KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.00787357
142* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00075891
143CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.99778610
144* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.99657656
145* ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99225547
146TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97928341
147NOTCH1_21737748_ChIP-Seq_TLL_Human0.97398441
148ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95525214
149TCF3_18692474_ChIP-Seq_MEFs_Mouse0.95155102
150PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.93106093
151SRY_22984422_ChIP-ChIP_TESTIS_Rat0.92180176
152CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91773706
153* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.89858259
154* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88534766
155* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.86785816
156* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.86737153
157PADI4_21655091_ChIP-ChIP_MCF-7_Human0.86369621
158YY1_22570637_ChIP-Seq_MALME-3M_Human0.85684936
159SOX2_18692474_ChIP-Seq_MEFs_Mouse0.85592483
160BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85474413
161SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.84558241

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization4.82218577
2MP0010094_abnormal_chromosome_stability4.55751567
3MP0003693_abnormal_embryo_hatching4.51465300
4MP0003111_abnormal_nucleus_morphology4.45960915
5MP0005451_abnormal_body_composition4.41593129
6MP0008057_abnormal_DNA_replication4.36549298
7MP0004957_abnormal_blastocyst_morpholog3.86779852
8MP0008438_abnormal_cutaneous_collagen3.82382560
9MP0003077_abnormal_cell_cycle3.70927823
10MP0008058_abnormal_DNA_repair3.59331825
11MP0003303_peritoneal_inflammation3.44963731
12MP0008877_abnormal_DNA_methylation3.29695186
13MP0001929_abnormal_gametogenesis2.82971856
14MP0003950_abnormal_plasma_membrane2.78819359
15MP0008007_abnormal_cellular_replicative2.72686509
16MP0009697_abnormal_copulation2.55801104
17MP0003698_abnormal_male_reproductive2.51784445
18MP0002210_abnormal_sex_determination2.42896421
19MP0005058_abnormal_lysosome_morphology2.41880999
20MP0004510_myositis2.34501393
21MP0003786_premature_aging2.22653271
22MP0002653_abnormal_ependyma_morphology2.18394813
23MP0008932_abnormal_embryonic_tissue2.16043787
24MP0001145_abnormal_male_reproductive2.15652761
25MP0009840_abnormal_foam_cell2.15386852
26MP0000350_abnormal_cell_proliferation2.11259620
27MP0002332_abnormal_exercise_endurance2.11166719
28MP0003705_abnormal_hypodermis_morpholog2.09568553
29MP0001730_embryonic_growth_arrest2.03194767
30MP0003656_abnormal_erythrocyte_physiolo2.01029404
31MP0000490_abnormal_crypts_of2.00080370
32MP0005275_abnormal_skin_tensile1.98004980
33MP0003123_paternal_imprinting1.96021177
34MP0003453_abnormal_keratinocyte_physiol1.94768441
35MP0000343_altered_response_to1.85759095
36MP0003300_gastrointestinal_ulcer1.84905347
37MP0003221_abnormal_cardiomyocyte_apopto1.83664850
38MP0006292_abnormal_olfactory_placode1.82831020
39MP0000653_abnormal_sex_gland1.81009919
40MP0010307_abnormal_tumor_latency1.80917717
41MP0003806_abnormal_nucleotide_metabolis1.80424753
42MP0004133_heterotaxia1.80220589
43MP0002396_abnormal_hematopoietic_system1.77871740
44MP0001542_abnormal_bone_strength1.72194080
45MP0003091_abnormal_cell_migration1.67769697
46MP0003566_abnormal_cell_adhesion1.67753815
47MP0004272_abnormal_basement_membrane1.63935564
48MP0001672_abnormal_embryogenesis/_devel1.62832453
49MP0005380_embryogenesis_phenotype1.62832453
50MP0005397_hematopoietic_system_phenotyp1.62091420
51MP0001545_abnormal_hematopoietic_system1.62091420
52MP0010352_gastrointestinal_tract_polyps1.60473434
53MP0001697_abnormal_embryo_size1.58179775
54MP0002161_abnormal_fertility/fecundity1.57512039
55MP0000313_abnormal_cell_death1.57283440
56MP0002084_abnormal_developmental_patter1.54565969
57MP0002080_prenatal_lethality1.53051641
58MP0002085_abnormal_embryonic_tissue1.50235156
59MP0009764_decreased_sensitivity_to1.49459758
60MP0005023_abnormal_wound_healing1.49409016
61MP0004808_abnormal_hematopoietic_stem1.47792498
62MP0002160_abnormal_reproductive_system1.45406319
63MP0008004_abnormal_stomach_pH1.45034089
64MP0003984_embryonic_growth_retardation1.43225352
65MP0001293_anophthalmia1.43068111
66MP0005623_abnormal_meninges_morphology1.42336038
67MP0003172_abnormal_lysosome_physiology1.42117797
68MP0005257_abnormal_intraocular_pressure1.41576838
69MP0002088_abnormal_embryonic_growth/wei1.39327585
70MP0002019_abnormal_tumor_incidence1.34721043
71MP0002086_abnormal_extraembryonic_tissu1.32416665
72MP0008995_early_reproductive_senescence1.31423798
73MP0004197_abnormal_fetal_growth/weight/1.30498841
74MP0005503_abnormal_tendon_morphology1.27476995
75MP0001727_abnormal_embryo_implantation1.23447415
76MP0003448_altered_tumor_morphology1.22968436
77MP0001879_abnormal_lymphatic_vessel1.21700511
78MP0002060_abnormal_skin_morphology1.21476744
79MP0003119_abnormal_digestive_system1.21412700
80MP0005165_increased_susceptibility_to1.20211085
81MP0003279_aneurysm1.19304599
82MP0005083_abnormal_biliary_tract1.19030436
83MP0004947_skin_inflammation1.17682341
84MP0002102_abnormal_ear_morphology1.15547504
85MP0010234_abnormal_vibrissa_follicle1.14688921
86MP0000358_abnormal_cell_content/1.13910013
87MP0002148_abnormal_hypersensitivity_rea1.09433945
88MP0004185_abnormal_adipocyte_glucose1.07077210
89MP0005164_abnormal_response_to1.06860355
90MP0003315_abnormal_perineum_morphology1.06118520
91MP0003718_maternal_effect1.04995721
92MP0004147_increased_porphyrin_level1.02915547
93MP0009384_cardiac_valve_regurgitation1.02010063
94MP0003567_abnormal_fetal_cardiomyocyte1.01530551
95MP0009785_altered_susceptibility_to1.01328369
96MP0003890_abnormal_embryonic-extraembry1.01125266
97MP0005389_reproductive_system_phenotype1.00895720
98MP0005174_abnormal_tail_pigmentation1.00720754
99MP0005508_abnormal_skeleton_morphology1.00433059
100MP0001243_abnormal_dermal_layer0.98962390
101MP0004264_abnormal_extraembryonic_tissu0.98520504
102MP0006082_CNS_inflammation0.97283529
103MP0002896_abnormal_bone_mineralization0.94824521
104MP0000703_abnormal_thymus_morphology0.92001455
105MP0003121_genomic_imprinting0.90370513
106MP0002132_abnormal_respiratory_system0.90176795
107MP0000371_diluted_coat_color0.89723568
108* MP0002398_abnormal_bone_marrow0.87543708
109MP0005076_abnormal_cell_differentiation0.86912665
110MP0001853_heart_inflammation0.86157755
111MP0005075_abnormal_melanosome_morpholog0.85536832
112MP0003436_decreased_susceptibility_to0.84208037
113MP0002722_abnormal_immune_system0.82119549
114MP0001849_ear_inflammation0.81268810
115MP0001216_abnormal_epidermal_layer0.80865357
116MP0000689_abnormal_spleen_morphology0.80795684
117MP0001119_abnormal_female_reproductive0.80074792
118MP0000749_muscle_degeneration0.80066636
119MP0000015_abnormal_ear_pigmentation0.78876286
120MP0005167_abnormal_blood-brain_barrier0.78754607
121MP0000858_altered_metastatic_potential0.78738172
122MP0002295_abnormal_pulmonary_circulatio0.78232346
123MP0005666_abnormal_adipose_tissue0.78053771
124MP0005384_cellular_phenotype0.77367177
125MP0009333_abnormal_splenocyte_physiolog0.77338694
126MP0004233_abnormal_muscle_weight0.76699327
127MP0000604_amyloidosis0.75637837
128MP0003186_abnormal_redox_activity0.75057888
129MP0009765_abnormal_xenobiotic_induced0.74999758
130MP0003075_altered_response_to0.73247623
131MP0009763_increased_sensitivity_to0.73214650
132MP0005193_abnormal_anterior_eye0.73107930
133MP0000733_abnormal_muscle_development0.72352333
134MP0002092_abnormal_eye_morphology0.71865081
135MP0003283_abnormal_digestive_organ0.71589566
136MP0003861_abnormal_nervous_system0.71515478
137MP0003136_yellow_coat_color0.71295285
138MP0005197_abnormal_uvea_morphology0.71123417
139MP0005266_abnormal_metabolism0.70233974
140MP0005621_abnormal_cell_physiology0.70181463
141MP0001191_abnormal_skin_condition0.70024893
142MP0005390_skeleton_phenotype0.69062082
143MP0005595_abnormal_vascular_smooth0.69057094
144MP0003699_abnormal_female_reproductive0.66740326
145MP0005647_abnormal_sex_gland0.65960965
146MP0001881_abnormal_mammary_gland0.65796890
147* MP0002429_abnormal_blood_cell0.64171676
148MP0009278_abnormal_bone_marrow0.63664600
149MP0000537_abnormal_urethra_morphology0.63639532
150MP0003941_abnormal_skin_development0.63058923
151MP0008770_decreased_survivor_rate0.62741653
152MP0001919_abnormal_reproductive_system0.61420458
153MP0002877_abnormal_melanocyte_morpholog0.61016918
154MP0000477_abnormal_intestine_morphology0.59975431
155MP0002111_abnormal_tail_morphology0.56868376
156MP0002095_abnormal_skin_pigmentation0.56335197
157MP0006035_abnormal_mitochondrial_morpho0.55636024
158MP0006036_abnormal_mitochondrial_physio0.54866205
159MP0002938_white_spotting0.54207478
160MP0001286_abnormal_eye_development0.53808998
161MP0003943_abnormal_hepatobiliary_system0.53550780
162MP0002234_abnormal_pharynx_morphology0.52858602
163MP0001915_intracranial_hemorrhage0.52016281
164MP0002282_abnormal_trachea_morphology0.51531760
165MP0006054_spinal_hemorrhage0.49210738
166MP0003937_abnormal_limbs/digits/tail_de0.48151154
167MP0000432_abnormal_head_morphology0.46430714

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.68989746
2Dynein arm defect of respiratory motile cilia (HP:0012255)5.13231832
3Absent/shortened dynein arms (HP:0200106)5.13231832
4Abnormality of glycolipid metabolism (HP:0010969)4.83376787
5Abnormality of liposaccharide metabolism (HP:0010968)4.83376787
6Abnormality of glycosphingolipid metabolism (HP:0004343)4.83376787
7Abnormal number of erythroid precursors (HP:0012131)4.59162262
8Abnormality of cells of the erythroid lineage (HP:0012130)4.55960367
9Abnormal respiratory epithelium morphology (HP:0012253)4.28399882
10Abnormal respiratory motile cilium morphology (HP:0005938)4.28399882
11Birth length less than 3rd percentile (HP:0003561)4.20199087
12Abnormal respiratory motile cilium physiology (HP:0012261)3.82621281
13Premature rupture of membranes (HP:0001788)3.80835559
14Reticulocytosis (HP:0001923)3.74183939
15Supernumerary spleens (HP:0009799)3.72969080
16Reticulocytopenia (HP:0001896)3.65914086
17Chronic bronchitis (HP:0004469)3.61415527
18Progressive external ophthalmoplegia (HP:0000590)3.59873990
19Abnormality of the heme biosynthetic pathway (HP:0010472)3.58047034
20Rhinitis (HP:0012384)3.50170600
21Fatigue (HP:0012378)3.46471563
22Ependymoma (HP:0002888)3.42819078
23Spondylolisthesis (HP:0003302)3.42649551
24Aplastic anemia (HP:0001915)3.41496185
25Selective tooth agenesis (HP:0001592)3.37236021
26Vertebral compression fractures (HP:0002953)3.24089492
27Impulsivity (HP:0100710)3.22930609
28Abnormal spermatogenesis (HP:0008669)3.21956289
29Chromosomal breakage induced by crosslinking agents (HP:0003221)3.18499436
30Nuclear cataract (HP:0100018)3.14430892
3111 pairs of ribs (HP:0000878)3.13031920
32Chromsome breakage (HP:0040012)3.07493048
33Breast hypoplasia (HP:0003187)3.07135492
34Nasal polyposis (HP:0100582)3.06519506
35Insomnia (HP:0100785)3.05664974
36Absent thumb (HP:0009777)3.02799306
37Medulloblastoma (HP:0002885)3.00137417
38Abnormality of the anterior horn cell (HP:0006802)2.99734411
39Degeneration of anterior horn cells (HP:0002398)2.99734411
40Abnormal ciliary motility (HP:0012262)2.99672436
41Progressive muscle weakness (HP:0003323)2.92469397
42Agnosia (HP:0010524)2.92347919
43Sensory axonal neuropathy (HP:0003390)2.88880888
44Protrusio acetabuli (HP:0003179)2.88844894
45Oral leukoplakia (HP:0002745)2.87541425
46Ragged-red muscle fibers (HP:0003200)2.86019712
47Abnormality of chromosome stability (HP:0003220)2.83110968
48Infertility (HP:0000789)2.80668669
49Albinism (HP:0001022)2.74931450
50Abnormality of the preputium (HP:0100587)2.74868092
51Polycythemia (HP:0001901)2.74619890
52Aplasia/Hypoplasia of the uvula (HP:0010293)2.74145093
53Patellar aplasia (HP:0006443)2.71499990
54Short nail (HP:0001799)2.69055391
55Disinhibition (HP:0000734)2.68869951
56Myelodysplasia (HP:0002863)2.67152844
57Colon cancer (HP:0003003)2.66245171
58Meckel diverticulum (HP:0002245)2.64006553
59Interstitial pulmonary disease (HP:0006530)2.62699511
60Pallor (HP:0000980)2.62694465
61Carpal bone hypoplasia (HP:0001498)2.62132330
62Diaphragmatic weakness (HP:0009113)2.61139895
63Abnormality of the ileum (HP:0001549)2.56607888
64Entropion (HP:0000621)2.56312416
65Rhabdomyosarcoma (HP:0002859)2.55958279
66Cervical subluxation (HP:0003308)2.55438253
67Loss of speech (HP:0002371)2.51616660
68Rough bone trabeculation (HP:0100670)2.48812061
69Dysostosis multiplex (HP:0000943)2.48616231
70Aplasia/Hypoplasia of the patella (HP:0006498)2.48470532
71Atrophic scars (HP:0001075)2.47809485
72Spinal rigidity (HP:0003306)2.47024507
73Basal cell carcinoma (HP:0002671)2.43847817
74Cholecystitis (HP:0001082)2.43682830
75Abnormal gallbladder physiology (HP:0012438)2.43682830
76Abnormality of the labia minora (HP:0012880)2.42243742
77Abnormality of the distal phalanges of the toes (HP:0010182)2.37792851
78Abnormality of the nasal mucosa (HP:0000433)2.37759754
79Duodenal stenosis (HP:0100867)2.36858621
80Small intestinal stenosis (HP:0012848)2.36858621
81Macrocytic anemia (HP:0001972)2.33976278
82Bladder diverticulum (HP:0000015)2.32954694
83Flat cornea (HP:0007720)2.32146334
84Missing ribs (HP:0000921)2.32133066
85Neoplasm of the oral cavity (HP:0100649)2.30910452
86Sloping forehead (HP:0000340)2.30385993
87Horseshoe kidney (HP:0000085)2.29668240
88Bone marrow hypocellularity (HP:0005528)2.29141367
89Neoplasm of the pancreas (HP:0002894)2.27715046
90Nephronophthisis (HP:0000090)2.27090121
91Cholelithiasis (HP:0001081)2.26881803
92Tongue fasciculations (HP:0001308)2.26855963
93Asplenia (HP:0001746)2.25458877
94Azoospermia (HP:0000027)2.25168776
95Orthostatic hypotension (HP:0001278)2.24812595
96Bronchitis (HP:0012387)2.24439988
97Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.23640050
98Absent radius (HP:0003974)2.22221905
99Wormian bones (HP:0002645)2.21591352
100Autoimmune thrombocytopenia (HP:0001973)2.20738073
101Ankle contracture (HP:0006466)2.20407564
102Short middle phalanx of the 5th finger (HP:0004220)2.19317386
103Abnormality of reticulocytes (HP:0004312)2.18857842
104Follicular hyperkeratosis (HP:0007502)2.15732369
105Bronchiectasis (HP:0002110)2.15305962
106Poikilocytosis (HP:0004447)2.14044610
107Abdominal situs inversus (HP:0003363)2.12704301
108Abnormality of abdominal situs (HP:0011620)2.12704301
109Myocardial infarction (HP:0001658)2.12055946
110Osteolytic defects of the hand bones (HP:0009699)2.11765507
111Osteolytic defects of the phalanges of the hand (HP:0009771)2.11765507
112Absent forearm bone (HP:0003953)2.11399350
113Aplasia involving forearm bones (HP:0009822)2.11399350
114Cerebral hypomyelination (HP:0006808)2.11370496
115Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.10225491
116Squamous cell carcinoma (HP:0002860)2.10222494
117Thoracolumbar scoliosis (HP:0002944)2.10148882
118Hyperacusis (HP:0010780)2.09512617
119Spinal muscular atrophy (HP:0007269)2.09114418
120Paralysis (HP:0003470)2.08960874
121Tetraparesis (HP:0002273)2.08906150
122Elbow flexion contracture (HP:0002987)2.08254742
123Apathy (HP:0000741)2.07343310
124Nonimmune hydrops fetalis (HP:0001790)2.06499958
125Facial cleft (HP:0002006)2.06443318
126Astrocytoma (HP:0009592)2.06178489
127Abnormality of the astrocytes (HP:0100707)2.06178489
128Abnormal number of incisors (HP:0011064)2.05700497
129Aplasia/Hypoplasia of the spleen (HP:0010451)2.05699485
130Abnormality of the duodenum (HP:0002246)2.05649233
131Impaired proprioception (HP:0010831)2.05151532
132Ectopic kidney (HP:0000086)2.04397316
133Long toe (HP:0010511)2.04209343
134Neurofibrillary tangles (HP:0002185)2.04005439
135Spinal cord lesions (HP:0100561)2.03596367
136Syringomyelia (HP:0003396)2.03596367
137Hypoplasia of the capital femoral epiphysis (HP:0003090)2.03553175
138Onycholysis (HP:0001806)2.03365015
139Cortical dysplasia (HP:0002539)2.02850467
140Atrophy/Degeneration involving motor neurons (HP:0007373)1.99895533
141Pancytopenia (HP:0001876)1.99789737
142Aplasia/Hypoplasia of the sacrum (HP:0008517)1.98343644
143Neoplasm of striated muscle (HP:0009728)1.97695018
144Vacuolated lymphocytes (HP:0001922)1.97462538
145Bradycardia (HP:0001662)1.97021180
146Increased connective tissue (HP:0009025)1.96949242
147Abnormality of the acetabulum (HP:0003170)1.96882655
148Gonadotropin excess (HP:0000837)1.95972758
149Triphalangeal thumb (HP:0001199)1.95181210
150Cerebral inclusion bodies (HP:0100314)1.94085655
151Fragile skin (HP:0001030)1.94019208
152Median cleft lip (HP:0000161)1.93930741
153Premature ovarian failure (HP:0008209)1.93166849
154Abnormality of polysaccharide metabolism (HP:0011012)1.92613181
155Abnormality of glycosaminoglycan metabolism (HP:0004371)1.92613181
156Abnormality of mucopolysaccharide metabolism (HP:0011020)1.92613181
157Diminished motivation (HP:0000745)1.92331279
158Absent frontal sinuses (HP:0002688)1.91604402
159Natal tooth (HP:0000695)1.91446631
160Hypoplasia of the radius (HP:0002984)1.91045968
161Progressive hearing impairment (HP:0001730)1.89482771
162Trismus (HP:0000211)1.88353146
163Prominent nose (HP:0000448)1.88289764
164Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.87098896
165Premature graying of hair (HP:0002216)1.86170309
166Abnormality of midbrain morphology (HP:0002418)1.86070108
167Molar tooth sign on MRI (HP:0002419)1.86070108
168Muscle fibrillation (HP:0010546)1.86015705
169Soft skin (HP:0000977)1.85618733
170Tracheoesophageal fistula (HP:0002575)1.84752794
171Abnormal gallbladder morphology (HP:0012437)1.84701477
172Muscle fiber atrophy (HP:0100295)1.83258173
173Aplasia/hypoplasia of the humerus (HP:0006507)1.83242964
174Pancreatic fibrosis (HP:0100732)1.82791417
175Glioma (HP:0009733)1.82583994
176Mucopolysacchariduria (HP:0008155)1.82015291
177Urinary glycosaminoglycan excretion (HP:0003541)1.82015291
178Shoulder girdle muscle weakness (HP:0003547)1.82011743
179Upper limb muscle weakness (HP:0003484)1.80968298
180Ankyloglossia (HP:0010296)1.79654563
181Renal duplication (HP:0000075)1.77883927
182Nausea (HP:0002018)1.76692186
183Ectropion (HP:0000656)1.74874792
184Abnormality of the gallbladder (HP:0005264)1.73730299
185Delayed closure of the anterior fontanelle (HP:0001476)1.73296884
186Abnormality of the thoracic spine (HP:0100711)1.73208759
187Hyperparathyroidism (HP:0000843)1.71476341
188Poikiloderma (HP:0001029)1.71029441
189Sparse lateral eyebrow (HP:0005338)1.70154204
190Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.69582637
191Upper motor neuron abnormality (HP:0002127)1.67797259
192Insidious onset (HP:0003587)1.67784137
193Termporal pattern (HP:0011008)1.67784137
194Distal upper limb amyotrophy (HP:0007149)1.67283166
195Upper limb amyotrophy (HP:0009129)1.67283166

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK34.97374827
2WEE14.23639255
3CDC73.63894578
4BUB13.47889628
5PDK33.09474101
6PDK43.09474101
7EIF2AK12.88000843
8TAOK22.85095390
9NEK22.70770188
10MST42.63252718
11PASK2.59227717
12LATS22.53943111
13EEF2K2.51672680
14TESK12.44492990
15EPHA22.42584768
16TTK2.38064897
17MAP3K32.33607422
18RIPK12.30154590
19ACVR1B2.27078078
20CDK122.18690020
21RPS6KB22.16863864
22STK162.13223965
23CLK12.09605466
24MAP3K142.06826879
25DDR22.01893888
26NME21.98274491
27PNCK1.96691050
28TLK11.89405487
29MAPKAPK31.86138470
30PDK21.80205830
31PLK11.79254194
32PRPF4B1.76848092
33VRK11.73963180
34CDK71.72247211
35ICK1.70318474
36PIM21.65192144
37TAOK11.64559393
38ATR1.62780258
39GRK71.62626619
40TSSK61.60664425
41CHEK21.57736316
42PDGFRA1.54260794
43AKT31.52672582
44ABL21.51852560
45SRPK11.49395571
46MAP3K61.47842045
47AURKB1.40851935
48NEK91.40014003
49PRKD31.36358781
50MOS1.36043955
51TRPM71.35869623
52* DYRK31.33251840
53AURKA1.32823800
54BRSK21.31959584
55CDK41.30292954
56CHEK11.27978285
57TESK21.27852782
58MET1.27496663
59PLK41.24780358
60MAP3K51.20381048
61PBK1.17694217
62BMPR21.16816551
63BMX1.15311655
64MST1R1.13342620
65PIM11.12514544
66CCNB11.09552922
67EIF2AK31.05412232
68MKNK11.04873928
69PLK31.03385088
70TBK11.01738108
71MAP3K81.00946793
72TGFBR11.00366623
73NEK10.99476083
74PAK40.98514629
75ZAK0.93045857
76MAP2K70.91924150
77ATM0.88569801
78BRSK10.86639151
79STK40.85953156
80CDK20.85519639
81MAP3K100.85175621
82SCYL20.84099356
83TTN0.83609407
84TGFBR20.83398970
85STK100.83290415
86PDGFRB0.81935318
87BRAF0.81312670
88BRD40.80495981
89IRAK10.75663789
90MKNK20.74412750
91PAK10.73432195
92JAK30.72497988
93CDC42BPA0.71976658
94LIMK10.70339324
95ERN10.68737537
96RPS6KA40.68733626
97CSNK2A20.67967197
98MYLK0.67691683
99MAP3K40.66871146
100MAP3K20.63056626
101DYRK20.62577059
102MAP3K110.62191831
103DYRK1B0.61183077
104ARAF0.61070073
105STK30.59364165
106RPS6KA50.58420602
107FLT30.58233018
108CDK80.56961591
109KSR10.56352052
110DAPK10.56162824
111CSNK2A10.55969887
112MAP3K10.55664042
113MARK30.55338256
114CAMK1D0.55032516
115CDK10.54942698
116CDK60.52827361
117PRKCI0.52521931
118MAP2K20.52133743
119ERBB40.50198880
120ALK0.49860431
121PTK20.49655012
122CHUK0.48218386
123LATS10.47579026
124IKBKB0.47391802
125MAPKAPK50.45281963
126CSNK1A1L0.44307816
127MAP4K20.41456601
128GSK3A0.40613182
129MAPK150.39598589
130CDK190.39163981
131KSR20.38953351
132MTOR0.37583922
133MATK0.36516227
134CAMK1G0.36252131
135CDK90.32263151
136MUSK0.31507698
137RAF10.30635854
138CSNK1E0.29990821
139AKT20.29659201
140RPS6KA10.28894016
141GRK60.27334713
142CSNK1D0.26600924
143PRKDC0.26569928
144PAK20.25156520
145MAP2K30.24000705
146MAPK140.22437455
147KIT0.21621071
148RPS6KB10.21347856
149GSK3B0.20798924
150CDK11A0.19227300
151EIF2AK20.19019654
152MAPK10.17794105
153YES10.17592091

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.79394786
2Mismatch repair_Homo sapiens_hsa034304.07698906
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.57490400
4Spliceosome_Homo sapiens_hsa030403.29548369
5RNA transport_Homo sapiens_hsa030133.27220641
6Ribosome_Homo sapiens_hsa030103.21289495
7Base excision repair_Homo sapiens_hsa034103.03654581
8RNA polymerase_Homo sapiens_hsa030202.99763357
9Homologous recombination_Homo sapiens_hsa034402.98434115
10Cell cycle_Homo sapiens_hsa041102.84224442
11Nucleotide excision repair_Homo sapiens_hsa034202.78057121
12Fanconi anemia pathway_Homo sapiens_hsa034602.76688828
13Malaria_Homo sapiens_hsa051442.63604541
14Proteasome_Homo sapiens_hsa030502.62014752
15Pyrimidine metabolism_Homo sapiens_hsa002402.57638837
16Basal transcription factors_Homo sapiens_hsa030222.51112418
17Other glycan degradation_Homo sapiens_hsa005112.47560741
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.43655381
19NF-kappa B signaling pathway_Homo sapiens_hsa040642.38733421
20One carbon pool by folate_Homo sapiens_hsa006702.29350596
21TNF signaling pathway_Homo sapiens_hsa046682.27076480
22Toll-like receptor signaling pathway_Homo sapiens_hsa046202.12858903
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.12742211
24Lysosome_Homo sapiens_hsa041422.09489825
25mRNA surveillance pathway_Homo sapiens_hsa030151.96573352
26RNA degradation_Homo sapiens_hsa030181.93518092
27Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.91957198
28Non-homologous end-joining_Homo sapiens_hsa034501.91009529
29p53 signaling pathway_Homo sapiens_hsa041151.82836513
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.77020443
31Vitamin B6 metabolism_Homo sapiens_hsa007501.74080348
32African trypanosomiasis_Homo sapiens_hsa051431.67663978
33Pertussis_Homo sapiens_hsa051331.67424850
34Systemic lupus erythematosus_Homo sapiens_hsa053221.67032569
35Sulfur metabolism_Homo sapiens_hsa009201.58875061
36Purine metabolism_Homo sapiens_hsa002301.56850625
37Selenocompound metabolism_Homo sapiens_hsa004501.56228476
38Salmonella infection_Homo sapiens_hsa051321.52014145
39NOD-like receptor signaling pathway_Homo sapiens_hsa046211.46624445
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.41701334
41Prion diseases_Homo sapiens_hsa050201.38388078
42Oocyte meiosis_Homo sapiens_hsa041141.35247839
43Rheumatoid arthritis_Homo sapiens_hsa053231.31106769
44Toxoplasmosis_Homo sapiens_hsa051451.24251935
45Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.21437906
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.19325830
47Osteoclast differentiation_Homo sapiens_hsa043801.17751805
48Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17510625
49Hepatitis C_Homo sapiens_hsa051601.16945535
50Pentose phosphate pathway_Homo sapiens_hsa000301.14648654
51Epstein-Barr virus infection_Homo sapiens_hsa051691.13549767
52Cysteine and methionine metabolism_Homo sapiens_hsa002701.10731213
53Pancreatic cancer_Homo sapiens_hsa052121.09234229
54Viral carcinogenesis_Homo sapiens_hsa052031.07689053
55Sphingolipid metabolism_Homo sapiens_hsa006001.04470891
56Jak-STAT signaling pathway_Homo sapiens_hsa046301.03997009
57Amoebiasis_Homo sapiens_hsa051461.03841737
58Adherens junction_Homo sapiens_hsa045200.98269909
59ECM-receptor interaction_Homo sapiens_hsa045120.96967506
60Proteoglycans in cancer_Homo sapiens_hsa052050.95886002
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.95749589
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94084809
63Adipocytokine signaling pathway_Homo sapiens_hsa049200.93402649
64Antigen processing and presentation_Homo sapiens_hsa046120.89123413
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.88009832
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87420220
67Alcoholism_Homo sapiens_hsa050340.86116023
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85992765
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85688574
70Herpes simplex infection_Homo sapiens_hsa051680.85298214
71Biosynthesis of amino acids_Homo sapiens_hsa012300.83414128
72Prolactin signaling pathway_Homo sapiens_hsa049170.81643341
73Focal adhesion_Homo sapiens_hsa045100.80284550
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79038459
75Folate biosynthesis_Homo sapiens_hsa007900.76801497
76Tuberculosis_Homo sapiens_hsa051520.76460054
77Prostate cancer_Homo sapiens_hsa052150.73875004
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73443850
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73422569
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72327114
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68753682
82Thyroid cancer_Homo sapiens_hsa052160.68095754
83HTLV-I infection_Homo sapiens_hsa051660.67155597
84Fructose and mannose metabolism_Homo sapiens_hsa000510.67061193
85Dorso-ventral axis formation_Homo sapiens_hsa043200.65899562
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63534021
87ErbB signaling pathway_Homo sapiens_hsa040120.61956458
88Phagosome_Homo sapiens_hsa041450.61312147
89Type II diabetes mellitus_Homo sapiens_hsa049300.61023120
90FoxO signaling pathway_Homo sapiens_hsa040680.60169978
91Huntingtons disease_Homo sapiens_hsa050160.59963940
92Sulfur relay system_Homo sapiens_hsa041220.59202133
93Glutathione metabolism_Homo sapiens_hsa004800.57938693
94Renal cell carcinoma_Homo sapiens_hsa052110.57884821
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56885884
96Melanoma_Homo sapiens_hsa052180.54654486
97Vibrio cholerae infection_Homo sapiens_hsa051100.51889762
98Bladder cancer_Homo sapiens_hsa052190.50303371
99Leishmaniasis_Homo sapiens_hsa051400.50033134
100VEGF signaling pathway_Homo sapiens_hsa043700.49726840
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49148064
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47794118
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47581298
104Hedgehog signaling pathway_Homo sapiens_hsa043400.46897816
105MicroRNAs in cancer_Homo sapiens_hsa052060.46212217
106mTOR signaling pathway_Homo sapiens_hsa041500.45282614
107Protein export_Homo sapiens_hsa030600.45219318
108Basal cell carcinoma_Homo sapiens_hsa052170.44876220
109Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41350021
110Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40920547
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.40082384
112Colorectal cancer_Homo sapiens_hsa052100.39912110
113Apoptosis_Homo sapiens_hsa042100.38783644
114Drug metabolism - other enzymes_Homo sapiens_hsa009830.37742118
115Legionellosis_Homo sapiens_hsa051340.36264310
116Hippo signaling pathway_Homo sapiens_hsa043900.35009093
117Linoleic acid metabolism_Homo sapiens_hsa005910.34275667
118Notch signaling pathway_Homo sapiens_hsa043300.33361250
119Cyanoamino acid metabolism_Homo sapiens_hsa004600.32926432
120Carbon metabolism_Homo sapiens_hsa012000.32471420
121Small cell lung cancer_Homo sapiens_hsa052220.31948342
122Glucagon signaling pathway_Homo sapiens_hsa049220.29729797
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.29715917
124Wnt signaling pathway_Homo sapiens_hsa043100.28857470
125Hepatitis B_Homo sapiens_hsa051610.28486526
126Acute myeloid leukemia_Homo sapiens_hsa052210.27765458
127Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.26565222
128Shigellosis_Homo sapiens_hsa051310.26343083
129Galactose metabolism_Homo sapiens_hsa000520.25169161
130Chronic myeloid leukemia_Homo sapiens_hsa052200.24440857
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.24403049
132TGF-beta signaling pathway_Homo sapiens_hsa043500.23729249
133N-Glycan biosynthesis_Homo sapiens_hsa005100.23215101
134Pyruvate metabolism_Homo sapiens_hsa006200.22777880
135alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21459786
136Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.20501443
137Thyroid hormone signaling pathway_Homo sapiens_hsa049190.20192431
138Metabolic pathways_Homo sapiens_hsa011000.19670356
139Arachidonic acid metabolism_Homo sapiens_hsa005900.19142399
140HIF-1 signaling pathway_Homo sapiens_hsa040660.17958766
141Measles_Homo sapiens_hsa051620.17151916
142Pathways in cancer_Homo sapiens_hsa052000.16804631
143Fatty acid biosynthesis_Homo sapiens_hsa000610.13399113
144Maturity onset diabetes of the young_Homo sapiens_hsa049500.13302727
145Hematopoietic cell lineage_Homo sapiens_hsa046400.12886688
146Glycerophospholipid metabolism_Homo sapiens_hsa005640.12226833
147Regulation of autophagy_Homo sapiens_hsa041400.09465102
148Renin-angiotensin system_Homo sapiens_hsa046140.09195559
149Influenza A_Homo sapiens_hsa051640.09123788
150Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.08594769
151Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.07998695
152Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.07924053
153Inositol phosphate metabolism_Homo sapiens_hsa005620.07241893

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