DYRK1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of nuclear-localized protein kinases. The encoded protein participates in the regulation of the cell cycle. Expression of this gene may be altered in tumor cells, and mutations in this gene were found to cause abdominal obesity-metabolic syndrome 3. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)9.69934209
2acrosome reaction (GO:0007340)9.39105494
3sarcoplasmic reticulum calcium ion transport (GO:0070296)8.46530288
4sperm-egg recognition (GO:0035036)8.16945524
5cell wall macromolecule metabolic process (GO:0044036)8.10846795
6cell wall macromolecule catabolic process (GO:0016998)8.10846795
7skeletal muscle contraction (GO:0003009)8.06273737
8acrosome assembly (GO:0001675)7.65844994
9plasma membrane fusion (GO:0045026)7.59582445
10regulation of skeletal muscle contraction (GO:0014819)7.45282623
11binding of sperm to zona pellucida (GO:0007339)7.44386017
12cilium or flagellum-dependent cell motility (GO:0001539)7.44149371
13actin-mediated cell contraction (GO:0070252)7.43342904
14axonemal dynein complex assembly (GO:0070286)7.42262140
15cell-cell recognition (GO:0009988)7.36412056
16multicellular organism reproduction (GO:0032504)7.30458430
17spermatid development (GO:0007286)7.22596942
18epithelial cilium movement (GO:0003351)7.13504578
19motile cilium assembly (GO:0044458)7.07353243
20regulation of cilium movement (GO:0003352)6.59364031
21reproduction (GO:0000003)6.36696618
22piRNA metabolic process (GO:0034587)6.23111788
23creatine metabolic process (GO:0006600)6.18165524
24synaptonemal complex organization (GO:0070193)6.06741999
25synaptonemal complex assembly (GO:0007130)5.93659525
26cilium movement (GO:0003341)5.88021489
27negative regulation of inclusion body assembly (GO:0090084)5.85828883
28actin filament-based movement (GO:0030048)5.80900604
29striated muscle contraction (GO:0006941)5.69807330
30sperm capacitation (GO:0048240)5.67295948
31epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.62454526
32myofibril assembly (GO:0030239)5.54497548
33male meiosis (GO:0007140)5.52304523
34organic cation transport (GO:0015695)5.42926826
35skeletal muscle fiber development (GO:0048741)5.24632326
36sarcomere organization (GO:0045214)5.13563497
37positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.08236808
38regulation of relaxation of muscle (GO:1901077)5.07822639
39response to muscle activity (GO:0014850)5.06483739
40spermatogenesis (GO:0007283)5.05194863
41male gamete generation (GO:0048232)5.02704821
42single fertilization (GO:0007338)5.01104623
43response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.90538103
44skeletal muscle adaptation (GO:0043501)4.89567627
45amino-acid betaine transport (GO:0015838)4.77169318
46carnitine transport (GO:0015879)4.77169318
47carnitine transmembrane transport (GO:1902603)4.72141379
48regulation of inclusion body assembly (GO:0090083)4.70380048
49gamete generation (GO:0007276)4.59495393
50response to inactivity (GO:0014854)4.58699892
51positive regulation of myotube differentiation (GO:0010831)4.58642709
52fertilization (GO:0009566)4.51108467
53cardiac myofibril assembly (GO:0055003)4.50399496
54calcium ion-dependent exocytosis (GO:0017156)4.43085627
55myotube cell development (GO:0014904)4.41800537
56muscle contraction (GO:0006936)4.41013884
57regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.33445724
58cardiac muscle contraction (GO:0060048)4.26083253
59cellular process involved in reproduction in multicellular organism (GO:0022412)4.18385451
60germ cell development (GO:0007281)4.17679896
61ventricular system development (GO:0021591)4.11072241
62left/right pattern formation (GO:0060972)4.06110345
63glycogen catabolic process (GO:0005980)4.05790617
64regulation of microtubule-based movement (GO:0060632)3.98185701
65actomyosin structure organization (GO:0031032)3.94548984
66muscle system process (GO:0003012)3.94282730
67microtubule severing (GO:0051013)3.90957782
68male meiosis I (GO:0007141)3.87591998
69striated muscle adaptation (GO:0014888)3.86978639
70carnitine shuttle (GO:0006853)3.85604957
71negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.85118670
72glucan catabolic process (GO:0009251)3.84901230
73NADH metabolic process (GO:0006734)3.74826854
74muscle organ morphogenesis (GO:0048644)3.73763250
75seminiferous tubule development (GO:0072520)3.71770755
76microtubule depolymerization (GO:0007019)3.70075469
77cardiac muscle hypertrophy (GO:0003300)3.69079509
78chromosome condensation (GO:0030261)3.68636451
79multicellular organismal reproductive process (GO:0048609)3.65566605
80DNA methylation involved in gamete generation (GO:0043046)3.64425539
81quaternary ammonium group transport (GO:0015697)3.64402047
82regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.61870876
83glucan biosynthetic process (GO:0009250)3.60835293
84glycogen biosynthetic process (GO:0005978)3.60835293
85cellular polysaccharide catabolic process (GO:0044247)3.55684284
86cell recognition (GO:0008037)3.53053736
87regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.51796044
88striated muscle hypertrophy (GO:0014897)3.50502292
89cranial nerve morphogenesis (GO:0021602)3.49657790
90muscle fiber development (GO:0048747)3.48012078
91chromosome organization involved in meiosis (GO:0070192)3.47629950
92DNA packaging (GO:0006323)3.46263515
93skeletal muscle tissue development (GO:0007519)3.41866028
94glycolytic process (GO:0006096)3.40069359
95regulation of actin filament-based movement (GO:1903115)3.38792118
96positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.38691061
97glycerol ether metabolic process (GO:0006662)3.34132388
98striated muscle atrophy (GO:0014891)3.34074209
99fatty acid transmembrane transport (GO:1902001)3.33767275
100muscle adaptation (GO:0043500)3.33427003
101muscle cell fate commitment (GO:0042693)3.32044484
1022-oxoglutarate metabolic process (GO:0006103)3.30374698
103meiotic nuclear division (GO:0007126)3.26823198
104genitalia morphogenesis (GO:0035112)3.25807112
105muscle organ development (GO:0007517)3.24015227
106RNA localization (GO:0006403)3.22531996
107muscle structure development (GO:0061061)3.22246409
108muscle hypertrophy (GO:0014896)3.20910547
109negative regulation of organelle assembly (GO:1902116)3.20787200
110cardiac muscle adaptation (GO:0014887)3.18762360
111cardiac muscle hypertrophy in response to stress (GO:0014898)3.18762360
112muscle hypertrophy in response to stress (GO:0003299)3.18762360
113meiosis I (GO:0007127)3.17760532
114polysaccharide catabolic process (GO:0000272)3.16830874
115glycogen metabolic process (GO:0005977)3.15791664
116gluconeogenesis (GO:0006094)3.15777871
117cellular glucan metabolic process (GO:0006073)3.10676674
118glucan metabolic process (GO:0044042)3.10676674
119positive regulation of glycolytic process (GO:0045821)3.10253076
120protein polyglutamylation (GO:0018095)3.09047867
121sexual reproduction (GO:0019953)3.08530280
122negative regulation of necroptotic process (GO:0060546)3.05778473
123multicellular organismal development (GO:0007275)3.05025851
124neuromuscular synaptic transmission (GO:0007274)3.02807001
125fructose metabolic process (GO:0006000)3.02367197
126macroautophagy (GO:0016236)3.00487543
127regulation of skeletal muscle cell differentiation (GO:2001014)3.00385699
128ether metabolic process (GO:0018904)3.00354824
129skeletal muscle cell differentiation (GO:0035914)2.98771014
130fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.98289522
131regulation of somitogenesis (GO:0014807)2.96813020
132intracellular estrogen receptor signaling pathway (GO:0030520)2.95673774
133negative regulation of cell size (GO:0045792)2.94686892
134regulation of NFAT protein import into nucleus (GO:0051532)2.94476678
135respiratory system process (GO:0003016)2.93730791
136negative regulation of skeletal muscle tissue development (GO:0048642)2.90524296
137cellular hyperosmotic response (GO:0071474)2.89431568
138skeletal muscle tissue regeneration (GO:0043403)2.87919425
139positive regulation of histone deacetylation (GO:0031065)2.87856826
140muscle tissue morphogenesis (GO:0060415)2.87766440
141regulation of cell communication by electrical coupling (GO:0010649)2.87416758
142regulation of myotube differentiation (GO:0010830)2.85552974
143muscle atrophy (GO:0014889)2.84952401
144hexose biosynthetic process (GO:0019319)2.83811998
145gene silencing by RNA (GO:0031047)2.81961916
146regulation of striated muscle contraction (GO:0006942)2.80784921
147negative regulation of potassium ion transmembrane transport (GO:1901380)2.80738462
148negative regulation of necrotic cell death (GO:0060547)2.76956955
149positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.76132191
150negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.75454223
151membrane depolarization during action potential (GO:0086010)2.74794969
152plasma membrane repair (GO:0001778)2.73679597
153gene silencing (GO:0016458)2.71361131
154regulation of calcium ion transmembrane transport (GO:1903169)2.71222123
155regulation of calcium ion transmembrane transporter activity (GO:1901019)2.71222123
156response to parathyroid hormone (GO:0071107)2.66752859
157chaperone-mediated protein complex assembly (GO:0051131)2.66308489
158adult heart development (GO:0007512)2.66191807
159CDP-diacylglycerol biosynthetic process (GO:0016024)2.64575027
160muscle cell cellular homeostasis (GO:0046716)2.62594225
161* myoblast fusion (GO:0007520)2.62407199
162histone H4 deacetylation (GO:0070933)2.61805443
163regulation of the force of heart contraction (GO:0002026)2.60827712
164peptidyl-lysine dimethylation (GO:0018027)2.59523981
165response to activity (GO:0014823)2.59421283
166spermatid nucleus differentiation (GO:0007289)2.58460296
167regulation of fatty acid beta-oxidation (GO:0031998)2.58460257
168* syncytium formation by plasma membrane fusion (GO:0000768)2.57029553
169nucleosome disassembly (GO:0006337)2.56851363
170protein-DNA complex disassembly (GO:0032986)2.56851363
171myotube differentiation (GO:0014902)2.55940546
172regulation of cilium assembly (GO:1902017)2.53632169
173chromatin silencing (GO:0006342)2.53058467
174monoubiquitinated protein deubiquitination (GO:0035520)2.49122104
175pyruvate metabolic process (GO:0006090)2.49119628
176lactate metabolic process (GO:0006089)2.43757819
177peptidyl-glutamic acid modification (GO:0018200)2.42890159
178protein localization to cilium (GO:0061512)2.38446013
179CDP-diacylglycerol metabolic process (GO:0046341)2.37155492
180regulation of chromatin binding (GO:0035561)2.36657258
181calcium ion import (GO:0070509)2.32970054
182alditol metabolic process (GO:0019400)2.32654419
183actin-myosin filament sliding (GO:0033275)2.31561686
184muscle filament sliding (GO:0030049)2.31561686
185sperm motility (GO:0030317)10.5542628

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.93801605
2EZH2_22144423_ChIP-Seq_EOC_Human4.43563255
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.69203103
4STAT6_21828071_ChIP-Seq_BEAS2B_Human3.36835243
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.13688850
6* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.90334690
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.61078878
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.32638723
9TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03817409
10VDR_21846776_ChIP-Seq_THP-1_Human2.00938912
11RACK7_27058665_Chip-Seq_MCF-7_Human1.91814125
12EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.85826916
13* SA1_27219007_Chip-Seq_ERYTHROID_Human1.84391862
14ELK3_25401928_ChIP-Seq_HUVEC_Human1.84246487
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.83526193
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81768802
17CTCF_27219007_Chip-Seq_ERYTHROID_Human1.79640236
18ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.78055194
19DNAJC2_21179169_ChIP-ChIP_NT2_Human1.64095684
20TCF7_22412390_ChIP-Seq_EML_Mouse1.63909008
21ERG_21242973_ChIP-ChIP_JURKAT_Human1.63147558
22GATA1_26923725_Chip-Seq_HPCs_Mouse1.63123627
23* LXR_22292898_ChIP-Seq_THP-1_Human1.61607811
24ESR2_21235772_ChIP-Seq_MCF-7_Human1.61242437
25ZNF263_19887448_ChIP-Seq_K562_Human1.60771007
26* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.59399913
27CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.56801093
28KDM2B_26808549_Chip-Seq_DND41_Human1.56778128
29ELF1_20517297_ChIP-Seq_JURKAT_Human1.56421761
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55217194
31* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54131681
32CTCF_27219007_Chip-Seq_Bcells_Human1.53919369
33* CREB1_26743006_Chip-Seq_LNCaP_Human1.53372631
34TBX20_22080862_ChIP-Seq_HEART_Mouse1.50957867
35TBX20_22328084_ChIP-Seq_HEART_Mouse1.50957867
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.50761950
37SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.50006755
38KDM2B_26808549_Chip-Seq_JURKAT_Human1.49500792
39NFIB_24661679_ChIP-Seq_LUNG_Mouse1.48776384
40ELK4_26923725_Chip-Seq_MESODERM_Mouse1.48509280
41ZNF274_21170338_ChIP-Seq_K562_Hela1.46640706
42MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.44923387
43SRY_22984422_ChIP-ChIP_TESTIS_Rat1.43120828
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.43007630
45P68_20966046_ChIP-Seq_HELA_Human1.42211728
46PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.42160521
47SMC4_20622854_ChIP-Seq_HELA_Human1.41919596
48MYC_22102868_ChIP-Seq_BL_Human1.40863609
49BCOR_27268052_Chip-Seq_Bcells_Human1.40241105
50WDR5_24793694_ChIP-Seq_LNCAP_Human1.37106876
51UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.35432601
52GATA1_19941827_ChIP-Seq_MEL_Mouse1.32613295
53* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.32215285
54TET1_21451524_ChIP-Seq_MESCs_Mouse1.29294123
55PPARA_22158963_ChIP-Seq_LIVER_Mouse1.28548491
56MYC_27129775_Chip-Seq_CORNEA_Mouse1.28355877
57MAF_26560356_Chip-Seq_TH1_Human1.27777454
58TP63_22573176_ChIP-Seq_HFKS_Human1.27579251
59PHF8_20622854_ChIP-Seq_HELA_Human1.27068139
60CTCF_21964334_Chip-Seq_Bcells_Human1.27032985
61MAF_26560356_Chip-Seq_TH2_Human1.26260217
62LXR_22158963_ChIP-Seq_LIVER_Mouse1.26157622
63* BCL6_27268052_Chip-Seq_Bcells_Human1.25723678
64YY1_22570637_ChIP-Seq_MALME-3M_Human1.25326029
65ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.24828917
66DROSHA_22980978_ChIP-Seq_HELA_Human1.24566498
67PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.24115838
68E2F1_20622854_ChIP-Seq_HELA_Human1.24048558
69KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.22446373
70* FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.21997524
71JARID2_20075857_ChIP-Seq_MESCs_Mouse1.20260233
72* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.17900333
73KDM2B_26808549_Chip-Seq_K562_Human1.17709162
74RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.17312817
75SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.17174434
76ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.16659542
77ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.16170954
78TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15688752
79* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.15232559
80MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.15045071
81ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.14706993
82E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.13613002
83RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.13360642
84TP53_20018659_ChIP-ChIP_R1E_Mouse1.13256580
85KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12866132
86RXR_22158963_ChIP-Seq_LIVER_Mouse1.11263199
87SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10167201
88GATA1_19941827_ChIP-Seq_MEL86_Mouse1.09975028
89KLF4_19829295_ChIP-Seq_ESCs_Human1.09827524
90SMC3_22415368_ChIP-Seq_MEFs_Mouse1.09744530
91REST_21632747_ChIP-Seq_MESCs_Mouse1.09286424
92STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.09124332
93OCT4_19829295_ChIP-Seq_ESCs_Human1.08604572
94EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07646070
95RAD21_21589869_ChIP-Seq_MESCs_Mouse1.06899296
96NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.06623997
97TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.06070198
98GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.05962195
99VDR_24763502_ChIP-Seq_THP-1_Human1.05602009
100WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.05532911
101* CTCF_20526341_ChIP-Seq_ESCs_Human1.04626204
102ZFP281_27345836_Chip-Seq_ESCs_Mouse1.04285023
103EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.04225396
104SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04139614
105UTX_26944678_Chip-Seq_JUKART_Human1.03839187
106RUNX1_27514584_Chip-Seq_MCF-7_Human1.03800205
107SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.03680419
108EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.02885468
109TP53_22127205_ChIP-Seq_IMR90_Human1.02750193
110LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.02656033
111P300_27058665_Chip-Seq_ZR-75-30cells_Human1.02468437
112CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01852571
113CTCF_21964334_ChIP-Seq_BJAB-B_Human1.01769829
114MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.01769731
115SOX2_22085726_ChIP-Seq_NPCs_Mouse1.01433859
116SUZ12_27294783_Chip-Seq_ESCs_Mouse1.01342855
117RXRA_24833708_ChIP-Seq_LIVER_Mouse1.00828271
118* P53_21459846_ChIP-Seq_SAOS-2_Human1.00674988
119SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.00550561
120PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00381477
121SOX2_21211035_ChIP-Seq_LN229_Human0.98984568
122EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.98968652
123RUNX1_26923725_Chip-Seq_HPCs_Mouse0.98674571
124TP53_23651856_ChIP-Seq_MEFs_Mouse0.97387590
125* RARA_24833708_ChIP-Seq_LIVER_Mouse0.96599499
126RARB_27405468_Chip-Seq_BRAIN_Mouse0.96019384
127MTF2_20144788_ChIP-Seq_MESCs_Mouse0.96015048
128JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.95926758
129GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95806129
130STAT1_17558387_ChIP-Seq_HELA_Human0.95731166
131* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95302540
132P63_26484246_Chip-Seq_KERATINOCYTES_Human0.95294717
133FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.94901940
134PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94481755
135SA1_27219007_Chip-Seq_Bcells_Human0.94416330
136SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94152055
137TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.93708389
138EP300_21415370_ChIP-Seq_HL-1_Mouse0.93295083
139SPI1_20517297_ChIP-Seq_HL60_Human0.92684357
140TET1_21490601_ChIP-Seq_MESCs_Mouse0.91646634
141CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91360196
142RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.89547355
143ZFP281_18757296_ChIP-ChIP_E14_Mouse0.88999146
144RAC3_21632823_ChIP-Seq_H3396_Human0.88615385
145CTCF_26484167_Chip-Seq_Bcells_Mouse0.88537150
146PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.88309595
147GATA3_21867929_ChIP-Seq_CD8_Mouse0.87106352
148IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.85920544
149CBP_20019798_ChIP-Seq_JUKART_Human0.85920544

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive4.20449113
2MP0003646_muscle_fatigue4.09216627
3MP0005451_abnormal_body_composition4.08388923
4MP0001929_abnormal_gametogenesis3.61235472
5MP0005670_abnormal_white_adipose3.54284242
6MP0000751_myopathy2.95386143
7MP0002653_abnormal_ependyma_morphology2.94243915
8MP0002332_abnormal_exercise_endurance2.85234229
9MP0004233_abnormal_muscle_weight2.79141236
10MP0008877_abnormal_DNA_methylation2.50040487
11MP0002837_dystrophic_cardiac_calcinosis2.41650959
12MP0002161_abnormal_fertility/fecundity2.29401279
13MP0004145_abnormal_muscle_electrophysio2.22883661
14MP0004130_abnormal_muscle_cell2.20244968
15MP0000749_muscle_degeneration2.12134335
16MP0004036_abnormal_muscle_relaxation2.09809306
17MP0002822_catalepsy2.07127578
18MP0002210_abnormal_sex_determination2.05262842
19MP0002269_muscular_atrophy2.01609055
20MP0005410_abnormal_fertilization11.1550489
21MP0004510_myositis1.87715992
22MP0004087_abnormal_muscle_fiber1.87225600
23MP0005666_abnormal_adipose_tissue1.84871796
24MP0008961_abnormal_basal_metabolism1.78468181
25MP0001145_abnormal_male_reproductive1.76602056
26MP0005623_abnormal_meninges_morphology1.72589035
27MP0004084_abnormal_cardiac_muscle1.59756251
28MP0002106_abnormal_muscle_physiology1.56725394
29MP0003705_abnormal_hypodermis_morpholog1.56245832
30MP0000759_abnormal_skeletal_muscle1.51107609
31MP0002127_abnormal_cardiovascular_syste1.50819659
32MP0000653_abnormal_sex_gland1.47419760
33MP0002249_abnormal_larynx_morphology1.43209659
34MP0002234_abnormal_pharynx_morphology1.37493738
35MP0004484_altered_response_of1.32928243
36MP0005375_adipose_tissue_phenotype1.32505714
37MP0002139_abnormal_hepatobiliary_system1.29565993
38MP0009278_abnormal_bone_marrow1.27293199
39MP0000569_abnormal_digit_pigmentation1.26689549
40MP0000747_muscle_weakness1.26596752
41MP0010630_abnormal_cardiac_muscle1.25136494
42MP0005365_abnormal_bile_salt1.24629312
43MP0005330_cardiomyopathy1.22518682
44MP0002909_abnormal_adrenal_gland1.20999001
45MP0005369_muscle_phenotype1.19806527
46MP0005620_abnormal_muscle_contractility1.17287124
47MP0002971_abnormal_brown_adipose1.12095255
48MP0005423_abnormal_somatic_nervous1.07739470
49MP0000013_abnormal_adipose_tissue1.07685362
50MP0010030_abnormal_orbit_morphology1.03089762
51MP0000733_abnormal_muscle_development1.02799960
52MP0005377_hearing/vestibular/ear_phenot1.02615845
53MP0003878_abnormal_ear_physiology1.02615845
54MP0005360_urolithiasis1.01225902
55MP0000678_abnormal_parathyroid_gland1.00779573
56MP0000750_abnormal_muscle_regeneration1.00496682
57MP0003283_abnormal_digestive_organ1.00125394
58MP0005266_abnormal_metabolism0.98542500
59MP0008260_abnormal_autophagy0.98333192
60MP0001849_ear_inflammation0.96531983
61MP0003115_abnormal_respiratory_system0.96350565
62MP0001765_abnormal_ion_homeostasis0.95334000
63MP0003252_abnormal_bile_duct0.95292567
64MP0004215_abnormal_myocardial_fiber0.94555398
65MP0001346_abnormal_lacrimal_gland0.93597495
66MP0003828_pulmonary_edema0.92570970
67MP0009840_abnormal_foam_cell0.91398830
68MP0003221_abnormal_cardiomyocyte_apopto0.86907279
69MP0010329_abnormal_lipoprotein_level0.86724644
70MP0001984_abnormal_olfaction0.85783124
71MP0000534_abnormal_ureter_morphology0.84220562
72MP0001348_abnormal_lacrimal_gland0.83829836
73MP0002282_abnormal_trachea_morphology0.82405326
74MP0003329_amyloid_beta_deposits0.81643015
75MP0003045_fibrosis0.81120312
76MP0009115_abnormal_fat_cell0.78060911
77MP0002108_abnormal_muscle_morphology0.76004072
78MP0003300_gastrointestinal_ulcer0.75163165
79MP0003879_abnormal_hair_cell0.74715067
80MP0004185_abnormal_adipocyte_glucose0.74360872
81MP0000003_abnormal_adipose_tissue0.72948376
82MP0005385_cardiovascular_system_phenoty0.71876878
83MP0001544_abnormal_cardiovascular_syste0.71876878
84MP0008775_abnormal_heart_ventricle0.71626507
85MP0004858_abnormal_nervous_system0.70991030
86MP0005397_hematopoietic_system_phenotyp0.69339323
87MP0001545_abnormal_hematopoietic_system0.69339323
88MP0005076_abnormal_cell_differentiation0.68978157
89MP0002118_abnormal_lipid_homeostasis0.68323723
90MP0003191_abnormal_cellular_cholesterol0.68143311
91MP0003137_abnormal_impulse_conducting0.66616891
92MP0006036_abnormal_mitochondrial_physio0.66090238
93MP0003123_paternal_imprinting0.64907333
94MP0005083_abnormal_biliary_tract0.64341833
95MP0006138_congestive_heart_failure0.64318755
96MP0002972_abnormal_cardiac_muscle0.60743655
97MP0003011_delayed_dark_adaptation0.60669537
98MP0000266_abnormal_heart_morphology0.60564227
99MP0005551_abnormal_eye_electrophysiolog0.60224188
100MP0008569_lethality_at_weaning0.58915279
101MP0005334_abnormal_fat_pad0.58694978
102MP0004085_abnormal_heartbeat0.58212942
103MP0009672_abnormal_birth_weight0.56401390
104MP0002078_abnormal_glucose_homeostasis0.55180745
105MP0004859_abnormal_synaptic_plasticity0.54900127
106MP0002160_abnormal_reproductive_system0.54792772
107MP0003656_abnormal_erythrocyte_physiolo0.53107830
108MP0002970_abnormal_white_adipose0.52922951
109MP0005248_abnormal_Harderian_gland0.52856214
110MP0000609_abnormal_liver_physiology0.51832357
111MP0008770_decreased_survivor_rate0.51137691
112MP0005085_abnormal_gallbladder_physiolo0.51120654
113MP0008995_early_reproductive_senescence0.50587318
114MP0005319_abnormal_enzyme/_coenzyme0.50053318
115MP0004811_abnormal_neuron_physiology0.48912022
116MP0005535_abnormal_body_temperature0.48603246
117MP0005058_abnormal_lysosome_morphology0.48397815
118MP0000955_abnormal_spinal_cord0.47982255
119MP0002114_abnormal_axial_skeleton0.47686120
120MP0003942_abnormal_urinary_system0.47659280
121MP0000681_abnormal_thyroid_gland0.47356772
122MP0008874_decreased_physiological_sensi0.46570023
123MP0005409_darkened_coat_color0.45712044
124MP0001299_abnormal_eye_distance/0.44965618
125MP0004270_analgesia0.44502592
126MP0002928_abnormal_bile_duct0.44126906
127MP0003948_abnormal_gas_homeostasis0.43773384
128MP0001324_abnormal_eye_pigmentation0.43640940
129MP0005636_abnormal_mineral_homeostasis0.42299622
130MP0006276_abnormal_autonomic_nervous0.42293534
131MP0005166_decreased_susceptibility_to0.41098808
132MP0002734_abnormal_mechanical_nocicepti0.39836209
133MP0009780_abnormal_chondrocyte_physiolo0.37727836
134MP0002932_abnormal_joint_morphology0.37675833
135MP0001661_extended_life_span0.36372103
136MP0002132_abnormal_respiratory_system0.34924709
137MP0001270_distended_abdomen0.34922381
138MP0003279_aneurysm0.34555763
139MP0008789_abnormal_olfactory_epithelium0.34490924
140MP0001943_abnormal_respiration0.33420317
141MP0000026_abnormal_inner_ear0.33193580
142MP0001727_abnormal_embryo_implantation0.32485237

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)9.23930445
2Absent/shortened dynein arms (HP:0200106)9.23930445
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.09778147
4Abnormal respiratory motile cilium physiology (HP:0012261)6.19040501
5Abnormal respiratory motile cilium morphology (HP:0005938)6.11975841
6Abnormal respiratory epithelium morphology (HP:0012253)6.11975841
7Nasal polyposis (HP:0100582)5.44507481
8Infertility (HP:0000789)5.31520351
9Rhinitis (HP:0012384)5.02729850
10Chronic bronchitis (HP:0004469)4.90856901
11Exercise-induced myalgia (HP:0003738)4.80663264
12Centrally nucleated skeletal muscle fibers (HP:0003687)4.75764073
13Abnormality of the nasal mucosa (HP:0000433)4.65124543
14Abnormal ciliary motility (HP:0012262)4.45080407
15Male infertility (HP:0003251)3.98892051
16Distal lower limb muscle weakness (HP:0009053)3.97869803
17Calcaneovalgus deformity (HP:0001848)3.82426769
18Myoglobinuria (HP:0002913)3.82031189
19Neck muscle weakness (HP:0000467)3.81592960
20Exercise-induced muscle cramps (HP:0003710)3.76989111
21Hyporeflexia of lower limbs (HP:0002600)3.73817720
22Difficulty running (HP:0009046)3.47429642
23Rimmed vacuoles (HP:0003805)3.42249906
24Asymmetric septal hypertrophy (HP:0001670)3.40278404
25Bronchitis (HP:0012387)3.33753080
26Deformed tarsal bones (HP:0008119)3.29954490
27Abnormality of the lower motor neuron (HP:0002366)3.14299037
28Distal lower limb amyotrophy (HP:0008944)3.11517973
29Bronchiectasis (HP:0002110)3.01309875
30Absent phalangeal crease (HP:0006109)2.96793683
31Malignant hyperthermia (HP:0002047)2.93626788
32Difficulty climbing stairs (HP:0003551)2.90803092
33Recurrent otitis media (HP:0000403)2.83988676
34Bundle branch block (HP:0011710)2.81966632
35Type 1 muscle fiber predominance (HP:0003803)2.80956400
36Abnormal gallbladder physiology (HP:0012438)2.75193023
37Cholecystitis (HP:0001082)2.75193023
38Nephronophthisis (HP:0000090)2.73437303
39EMG: neuropathic changes (HP:0003445)2.71461646
40Fetal akinesia sequence (HP:0001989)2.70440332
41Rhabdomyolysis (HP:0003201)2.69696292
42Muscle fiber splitting (HP:0003555)2.68760965
43Areflexia of lower limbs (HP:0002522)2.68284535
44Sudden death (HP:0001699)2.58741946
45Spinal rigidity (HP:0003306)2.54201448
46Increased connective tissue (HP:0009025)2.46284730
47Ulnar deviation of the wrist (HP:0003049)2.45886945
48Calf muscle hypertrophy (HP:0008981)2.43913043
49Slender build (HP:0001533)2.37215785
50Muscle hypertrophy of the lower extremities (HP:0008968)2.36770993
51Abnormality of the calcaneus (HP:0008364)2.36265619
52Weak cry (HP:0001612)2.33405892
53Waddling gait (HP:0002515)2.33241501
54Abnormal finger flexion creases (HP:0006143)2.31955654
55Neoplasm of the heart (HP:0100544)2.31621831
56Muscle fiber inclusion bodies (HP:0100299)2.31589876
57Recurrent bronchitis (HP:0002837)2.29017200
58Scapular winging (HP:0003691)2.27506071
59Heterotopia (HP:0002282)2.27278873
60Lower limb amyotrophy (HP:0007210)2.25417380
61Gowers sign (HP:0003391)2.18528080
62Dysmetric saccades (HP:0000641)2.18066626
63Dilated cardiomyopathy (HP:0001644)2.17789313
64Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.14602614
65Recurrent sinusitis (HP:0011108)2.11020500
66Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.08829018
67Distal upper limb amyotrophy (HP:0007149)2.04558834
68Upper limb amyotrophy (HP:0009129)2.04558834
69Hemorrhage of the eye (HP:0011885)2.04300083
70Abnormal spermatogenesis (HP:0008669)2.03493149
71Stridor (HP:0010307)2.02698663
72Abnormality of the foot musculature (HP:0001436)2.01622665
73Hip contracture (HP:0003273)2.00874582
74Limb-girdle muscle atrophy (HP:0003797)1.98300633
75Foot dorsiflexor weakness (HP:0009027)1.98085679
76Abnormality of the renal medulla (HP:0100957)1.96700316
77Hyperacusis (HP:0010780)1.95653225
78Progressive muscle weakness (HP:0003323)1.94795678
79Abnormality of the left ventricular outflow tract (HP:0011103)1.94383762
80Subaortic stenosis (HP:0001682)1.94383762
81Hand muscle atrophy (HP:0009130)1.93985133
82Abnormality of the calf musculature (HP:0001430)1.91568986
83Dyschromatopsia (HP:0007641)1.91304721
84Hyperkalemia (HP:0002153)1.91149743
85Ragged-red muscle fibers (HP:0003200)1.88389659
86Increased variability in muscle fiber diameter (HP:0003557)1.88015472
87Choroideremia (HP:0001139)1.87259116
88Obstructive sleep apnea (HP:0002870)1.87186460
89Myopathic facies (HP:0002058)1.87145896
90Muscular dystrophy (HP:0003560)1.86011533
91Central scotoma (HP:0000603)1.83239292
92Renovascular hypertension (HP:0100817)1.82585303
93Nonprogressive disorder (HP:0003680)1.81981544
94Heart block (HP:0012722)1.75477868
95Generalized muscle weakness (HP:0003324)1.75377979
96Lipoatrophy (HP:0100578)1.74942753
97Spastic tetraparesis (HP:0001285)1.74738462
98EMG: myopathic abnormalities (HP:0003458)1.74438475
99Bell-shaped thorax (HP:0001591)1.74121744
100Distal arthrogryposis (HP:0005684)1.73653213
101Abnormality of skeletal muscle fiber size (HP:0012084)1.71416981
102Muscle stiffness (HP:0003552)1.70737993
103Impulsivity (HP:0100710)1.70136734
104Reticulocytosis (HP:0001923)1.68995553
105Easy fatigability (HP:0003388)1.68093170
106Ankle clonus (HP:0011448)1.65916015
107Mildly elevated creatine phosphokinase (HP:0008180)1.64758368
108Nemaline bodies (HP:0003798)1.63879574
109Achilles tendon contracture (HP:0001771)1.63544472
110Ventricular fibrillation (HP:0001663)1.63020930
111Round ear (HP:0100830)1.62882954
112Ventricular tachycardia (HP:0004756)1.62526393
113Abnormal atrioventricular conduction (HP:0005150)1.62377455
114Proximal amyotrophy (HP:0007126)1.61983965
115Cerebral aneurysm (HP:0004944)1.61664443
116Abnormality of the aortic arch (HP:0012303)1.61394299
117Global brain atrophy (HP:0002283)1.60650241
118Elfin facies (HP:0004428)1.59621315
119Bulbar palsy (HP:0001283)1.59028541
120Muscle fiber atrophy (HP:0100295)1.58515620
121Myotonia (HP:0002486)1.58487005
122Fatigable weakness (HP:0003473)1.57837087
123Abnormality of the neuromuscular junction (HP:0003398)1.57837087
124Ventricular arrhythmia (HP:0004308)1.57741418
125Broad metatarsal (HP:0001783)1.57209681
126Ketosis (HP:0001946)1.56966231
127Tubular atrophy (HP:0000092)1.56916732
128Long toe (HP:0010511)1.56362211
129Frequent falls (HP:0002359)1.56186405
130Gonadotropin excess (HP:0000837)1.56007159
131Abnormality of the shoulder girdle musculature (HP:0001435)1.54692917
132Bowel incontinence (HP:0002607)1.54692295
133Respiratory insufficiency due to muscle weakness (HP:0002747)1.53864597
134Decreased central vision (HP:0007663)1.52737952
135Limb-girdle muscle weakness (HP:0003325)1.52077884
136Insomnia (HP:0100785)1.50353355
137Deformed sella turcica (HP:0002681)1.49972675
138Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.49847955
139Postural instability (HP:0002172)1.48737725
140Metatarsus adductus (HP:0001840)1.45860650
141Facial diplegia (HP:0001349)1.45522424
142Atrioventricular block (HP:0001678)1.44376747
143Oligomenorrhea (HP:0000876)1.44321687
144Tubulointerstitial abnormality (HP:0001969)1.41649694
145Hyperthyroidism (HP:0000836)1.41586399
146Rapidly progressive (HP:0003678)1.41469240
147Short palpebral fissure (HP:0012745)1.40625389
148Cholelithiasis (HP:0001081)1.40182971
149Abnormal large intestine physiology (HP:0012700)1.39877155
150Abnormality of the Achilles tendon (HP:0005109)1.38766156
151Hypoplastic ischia (HP:0003175)1.38511553
152Popliteal pterygium (HP:0009756)1.38133620
153Atelectasis (HP:0100750)1.35186977
154Paralysis (HP:0003470)1.33293491
155Insulin-resistant diabetes mellitus (HP:0000831)1.31431624
156Pelvic girdle muscle weakness (HP:0003749)1.28234495

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK35.66152198
2PDK45.66152198
3PRKD35.20937439
4ICK5.07154864
5TESK14.46248613
6PDK23.27281071
7TRIB32.75486670
8MAP3K102.10708980
9STK382.02516296
10EEF2K1.98164530
11PIK3CG1.96381647
12TTN1.95385174
13PTK2B1.80094730
14RIPK11.70559288
15CAMK1G1.61192056
16WNK41.55462277
17PHKG21.43376613
18PHKG11.43376613
19OBSCN1.42758431
20PRPF4B1.42725189
21SIK11.40817904
22ERN11.39483156
23NEK21.35582469
24CDK121.33680883
25PKN21.29544370
26TYRO31.26055993
27MAP2K41.11458754
28TNK21.10065138
29MAP2K21.09239341
30LMTK21.08498618
31SMG11.06367346
32TAOK11.06344043
33DMPK1.05149861
34PINK11.01839943
35MAP3K71.00559263
36NME11.00257060
37ARAF0.97774269
38PDK10.97701712
39CAMK1D0.96765182
40MTOR0.96630416
41WNK10.90087318
42MARK10.87818344
43PNCK0.86571681
44PRKAA10.85525059
45MAP3K30.81137581
46MAPK150.80315433
47PDPK10.78363386
48MOS0.78351949
49PTK60.77577693
50MAP3K130.77015723
51MARK20.75486228
52BRAF0.74870814
53LIMK10.72876383
54PDGFRA0.72596959
55CAMKK10.69912759
56TBK10.64247280
57RPS6KA60.64197236
58CAMK2G0.61732462
59MAPK70.60713483
60DYRK30.60033005
61SIK20.57978383
62BCKDK0.57928816
63MAP2K60.57243803
64TESK20.56327526
65PAK60.55546144
66NTRK20.54529214
67MAP3K60.54444455
68FGFR40.53485603
69MAPK40.49835924
70CDK190.48606400
71STK390.48295684
72NEK10.48144651
73AKT20.47991689
74MAPKAPK30.47817399
75BMX0.46181766
76MAP2K10.46073148
77PRKAA20.45727681
78PAK40.45392557
79MUSK0.44993995
80DAPK20.43180284
81GRK60.41676182
82RPS6KA10.40190317
83PRKCH0.39885163
84STK110.39670707
85PAK20.39065490
86LATS10.38943036
87DDR20.38854367
88RPS6KA20.38718386
89BLK0.38598375
90MAPK110.38306396
91ZAP700.37921362
92EPHA30.37803704
93SGK2230.37347468
94SGK4940.37347468
95EPHB10.37160057
96PRKD20.36638198
97RET0.35786651
98BRD40.35022759
99STK30.34598309
100* DYRK1B0.34466810
101MAP4K10.34435022
102MAP3K10.33173352
103CDC42BPA0.32240904
104PKN10.32093935
105PRKD10.31996941
106PRKG10.31864373
107MAP2K30.31745323
108HIPK20.31248087
109TRPM70.30444924
110MAP3K110.30343413
111SGK20.30053617
112PRKG20.29870795
113CDK60.29604593
114PDGFRB0.28413120
115IRAK30.27196169
116CAMK10.26934953
117STK38L0.26328368
118MAPK120.25754624
119TAOK20.25743588
120SGK30.25579972
121CAMK40.25298795
122MAPK80.23994477
123PTK20.23845143
124ROCK10.22080890
125FGFR20.21999098
126RPS6KA30.20690879
127PRKCZ0.20175263
128KSR20.19266115
129EPHB20.18852997
130DAPK30.16390127
131FGFR30.15788730
132PRKACG0.15424033
133CDK90.15238134
134PAK10.14635275
135CHEK10.14392616
136GSK3B0.14387028
137RPS6KL10.13680516
138RPS6KC10.13680516

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000613.10630923
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.83729235
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.47546230
4Pyruvate metabolism_Homo sapiens_hsa006202.46939293
5Propanoate metabolism_Homo sapiens_hsa006402.33459416
6Glucagon signaling pathway_Homo sapiens_hsa049222.32685509
7Fatty acid degradation_Homo sapiens_hsa000712.26659724
8PPAR signaling pathway_Homo sapiens_hsa033202.12610558
9Fatty acid metabolism_Homo sapiens_hsa012121.99909326
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.96191415
11Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.94499126
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.94359066
13Carbohydrate digestion and absorption_Homo sapiens_hsa049731.89372030
14Nitrogen metabolism_Homo sapiens_hsa009101.69954605
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.65793939
16Dorso-ventral axis formation_Homo sapiens_hsa043201.63846833
17Glycerolipid metabolism_Homo sapiens_hsa005611.58492084
18Carbon metabolism_Homo sapiens_hsa012001.54912979
19Adipocytokine signaling pathway_Homo sapiens_hsa049201.47866921
20Cardiac muscle contraction_Homo sapiens_hsa042601.42172032
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.33767632
22Bile secretion_Homo sapiens_hsa049761.33567093
23Arginine and proline metabolism_Homo sapiens_hsa003301.33424660
24AMPK signaling pathway_Homo sapiens_hsa041521.29607412
25Insulin resistance_Homo sapiens_hsa049311.28119429
26Fructose and mannose metabolism_Homo sapiens_hsa000511.23484854
27Lysine degradation_Homo sapiens_hsa003101.23185914
28Non-small cell lung cancer_Homo sapiens_hsa052231.22244428
29Fat digestion and absorption_Homo sapiens_hsa049751.20543508
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.20206771
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.17646009
32Selenocompound metabolism_Homo sapiens_hsa004501.17525008
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.16564030
34GnRH signaling pathway_Homo sapiens_hsa049121.14891693
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.12880992
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.10134273
37Biosynthesis of amino acids_Homo sapiens_hsa012301.10016227
38Glycerophospholipid metabolism_Homo sapiens_hsa005641.09745734
39Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.08461829
40Insulin signaling pathway_Homo sapiens_hsa049101.08454597
41Central carbon metabolism in cancer_Homo sapiens_hsa052301.08117484
42Insulin secretion_Homo sapiens_hsa049111.08065467
43cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07299182
44Endometrial cancer_Homo sapiens_hsa052131.06057949
45Dilated cardiomyopathy_Homo sapiens_hsa054141.05803613
46Thyroid hormone signaling pathway_Homo sapiens_hsa049191.03460055
47Type II diabetes mellitus_Homo sapiens_hsa049301.02108345
48Arginine biosynthesis_Homo sapiens_hsa002201.02007558
49Longevity regulating pathway - mammal_Homo sapiens_hsa042111.01743237
50Linoleic acid metabolism_Homo sapiens_hsa005911.00875447
51Neurotrophin signaling pathway_Homo sapiens_hsa047220.99168569
52ABC transporters_Homo sapiens_hsa020100.98922059
53Phenylalanine metabolism_Homo sapiens_hsa003600.97269141
54Sulfur relay system_Homo sapiens_hsa041220.96949432
55Olfactory transduction_Homo sapiens_hsa047400.90196123
56Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.89329710
57Renin secretion_Homo sapiens_hsa049240.88374044
58mTOR signaling pathway_Homo sapiens_hsa041500.87826524
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.86668012
60MAPK signaling pathway_Homo sapiens_hsa040100.86504030
61Pentose phosphate pathway_Homo sapiens_hsa000300.84553896
62Estrogen signaling pathway_Homo sapiens_hsa049150.84216517
63B cell receptor signaling pathway_Homo sapiens_hsa046620.82937506
64Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.82920967
65Gastric acid secretion_Homo sapiens_hsa049710.82909105
66Cholinergic synapse_Homo sapiens_hsa047250.82070596
67Aldosterone synthesis and secretion_Homo sapiens_hsa049250.80333765
68Viral myocarditis_Homo sapiens_hsa054160.79633540
69VEGF signaling pathway_Homo sapiens_hsa043700.79538322
70Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.79360218
71Amphetamine addiction_Homo sapiens_hsa050310.77648361
72Vitamin B6 metabolism_Homo sapiens_hsa007500.77252142
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76257048
74Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.75528906
75ErbB signaling pathway_Homo sapiens_hsa040120.72663924
76Oocyte meiosis_Homo sapiens_hsa041140.72470123
77Hedgehog signaling pathway_Homo sapiens_hsa043400.71615755
78FoxO signaling pathway_Homo sapiens_hsa040680.70847647
79Oxytocin signaling pathway_Homo sapiens_hsa049210.70654659
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69760049
81Choline metabolism in cancer_Homo sapiens_hsa052310.67816784
82Melanogenesis_Homo sapiens_hsa049160.66954975
83Circadian entrainment_Homo sapiens_hsa047130.66926096
84Bladder cancer_Homo sapiens_hsa052190.66829287
85Calcium signaling pathway_Homo sapiens_hsa040200.66741778
86Renal cell carcinoma_Homo sapiens_hsa052110.65586427
87Notch signaling pathway_Homo sapiens_hsa043300.65188023
88Salivary secretion_Homo sapiens_hsa049700.65066418
89Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64033087
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.63898293
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61794615
92Starch and sucrose metabolism_Homo sapiens_hsa005000.60284861
93Long-term potentiation_Homo sapiens_hsa047200.59101843
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.58743518
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.58561804
96Axon guidance_Homo sapiens_hsa043600.58220398
97Thyroid hormone synthesis_Homo sapiens_hsa049180.57050780
98Pancreatic cancer_Homo sapiens_hsa052120.56753751
99Circadian rhythm_Homo sapiens_hsa047100.55369339
100Long-term depression_Homo sapiens_hsa047300.53959568
101cAMP signaling pathway_Homo sapiens_hsa040240.53494800
102Endocytosis_Homo sapiens_hsa041440.53407105
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53260964
104Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53145171
105AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53131134
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.52979398
107Other glycan degradation_Homo sapiens_hsa005110.51166037
108Osteoclast differentiation_Homo sapiens_hsa043800.51111905
109Thyroid cancer_Homo sapiens_hsa052160.50867208
110Mineral absorption_Homo sapiens_hsa049780.50330276
111Prolactin signaling pathway_Homo sapiens_hsa049170.50329659
112Basal cell carcinoma_Homo sapiens_hsa052170.50269170
113Platelet activation_Homo sapiens_hsa046110.49595912
114Cysteine and methionine metabolism_Homo sapiens_hsa002700.48318428
115Tryptophan metabolism_Homo sapiens_hsa003800.48288638
116Glycosaminoglycan degradation_Homo sapiens_hsa005310.46799826
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46478043
118Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45730761
119Protein digestion and absorption_Homo sapiens_hsa049740.45252857
120Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43039457
121HIF-1 signaling pathway_Homo sapiens_hsa040660.43032896
122Amoebiasis_Homo sapiens_hsa051460.42980477
123Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42102592
124Colorectal cancer_Homo sapiens_hsa052100.41885113
125Chronic myeloid leukemia_Homo sapiens_hsa052200.38908826
126Pancreatic secretion_Homo sapiens_hsa049720.38821868
127Synaptic vesicle cycle_Homo sapiens_hsa047210.37265295
128Caffeine metabolism_Homo sapiens_hsa002320.36300872
129Glioma_Homo sapiens_hsa052140.34023815
130Inositol phosphate metabolism_Homo sapiens_hsa005620.31142797
131Peroxisome_Homo sapiens_hsa041460.29954395
132Acute myeloid leukemia_Homo sapiens_hsa052210.29761452
133Tight junction_Homo sapiens_hsa045300.29289241
134Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28962101
135Focal adhesion_Homo sapiens_hsa045100.25813964
136Galactose metabolism_Homo sapiens_hsa000520.25566272

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