DYNC1LI1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to light intermediate subunit family, whose members are components of the multiprotein cytoplasmic dynein complex, which is involved in intracellular trafficking and chromosome segregation during mitosis. The protein plays a role in moving the spindle assembly checkpoint (SAC) from kinetochores to spindle poles. The protein may also mediate binding to other cargo molecules to facilitate intracellular vesicle trafficking. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neurofilament cytoskeleton organization (GO:0060052)5.38468578
2negative regulation of dendrite morphogenesis (GO:0050774)5.21052536
3cell migration in hindbrain (GO:0021535)4.55077543
4nucleobase catabolic process (GO:0046113)3.99589514
5DNA damage response, detection of DNA damage (GO:0042769)3.96739034
6positive regulation of mitochondrial fission (GO:0090141)3.69927272
7establishment of protein localization to mitochondrial membrane (GO:0090151)3.58088989
8proteasome assembly (GO:0043248)3.56433279
9negative regulation of dendrite development (GO:2000171)3.46906133
10protein neddylation (GO:0045116)3.41336354
11de novo protein folding (GO:0006458)3.40069286
12de novo posttranslational protein folding (GO:0051084)3.39858251
13peripheral nervous system neuron development (GO:0048935)3.38762240
14protein deneddylation (GO:0000338)3.36162560
15sympathetic nervous system development (GO:0048485)3.32042001
16establishment of integrated proviral latency (GO:0075713)3.31581677
17chaperone-mediated protein transport (GO:0072321)3.28760157
18organelle disassembly (GO:1903008)3.28296333
19neuron cell-cell adhesion (GO:0007158)3.20688681
20neural tube formation (GO:0001841)3.05868452
21synaptic vesicle exocytosis (GO:0016079)3.03608497
22synaptic vesicle maturation (GO:0016188)3.03384610
23CENP-A containing nucleosome assembly (GO:0034080)3.03271061
24transcription elongation from RNA polymerase III promoter (GO:0006385)3.02080681
25termination of RNA polymerase III transcription (GO:0006386)3.02080681
26regulation of NFAT protein import into nucleus (GO:0051532)3.01627009
27chromatin remodeling at centromere (GO:0031055)2.99478275
28presynaptic membrane organization (GO:0097090)2.97327156
29regulation of relaxation of muscle (GO:1901077)2.97009092
30presynaptic membrane assembly (GO:0097105)2.96102932
31mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.96037468
32protein localization to cilium (GO:0061512)2.92156966
33negative regulation of homotypic cell-cell adhesion (GO:0034111)2.90031934
34regulation of synaptic vesicle exocytosis (GO:2000300)2.89852357
35protein localization to synapse (GO:0035418)2.86283848
36regulation of cell communication by electrical coupling (GO:0010649)2.83459905
37negative regulation of microtubule polymerization (GO:0031115)2.81884468
38detection of temperature stimulus involved in sensory perception (GO:0050961)2.81307710
39detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.81307710
40neuronal action potential propagation (GO:0019227)2.80289633
41DNA double-strand break processing (GO:0000729)2.77228181
42regulation of short-term neuronal synaptic plasticity (GO:0048172)2.77118164
43negative regulation of DNA recombination (GO:0045910)2.76794020
44DNA replication-independent nucleosome assembly (GO:0006336)2.75817106
45DNA replication-independent nucleosome organization (GO:0034724)2.75817106
46protein localization to mitochondrion (GO:0070585)2.75584287
47histone mRNA metabolic process (GO:0008334)2.75555032
48neuronal action potential (GO:0019228)2.75382581
49RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.74715771
50tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.74715771
51intraciliary transport (GO:0042073)2.73190759
52resolution of meiotic recombination intermediates (GO:0000712)2.71433829
53establishment of viral latency (GO:0019043)2.70818021
54regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.68538176
55neuron recognition (GO:0008038)2.68148637
56protein K11-linked ubiquitination (GO:0070979)2.67088072
57negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.64853232
58respiratory chain complex IV assembly (GO:0008535)2.64652287
59olfactory bulb development (GO:0021772)2.63623200
60mitochondrial respiratory chain complex I assembly (GO:0032981)2.63335327
61NADH dehydrogenase complex assembly (GO:0010257)2.63335327
62mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.63335327
63establishment of mitochondrion localization (GO:0051654)2.60666117
64inositol phosphate catabolic process (GO:0071545)2.59351141
65negative regulation of membrane potential (GO:0045837)2.58075963
66mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.57587929
67calcium-mediated signaling using intracellular calcium source (GO:0035584)2.57346901
68regulation of cofactor metabolic process (GO:0051193)2.57293624
69regulation of coenzyme metabolic process (GO:0051196)2.57293624
70vocalization behavior (GO:0071625)2.57249723
71nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.56587848
72exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.56523174
73histone exchange (GO:0043486)2.56347029
74protein localization to kinetochore (GO:0034501)2.56125699
75histone H2A acetylation (GO:0043968)2.56053002
76protein targeting to mitochondrion (GO:0006626)2.55641658
77ganglion development (GO:0061548)2.55384266
78regulation of synaptic vesicle transport (GO:1902803)2.54900902
79regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.53523152
80mitochondrion transport along microtubule (GO:0047497)2.53089881
81establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.53089881
82positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.52664958
83mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.52664958
84regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.52618323
85establishment of protein localization to mitochondrion (GO:0072655)2.52512449
86transcription from RNA polymerase III promoter (GO:0006383)2.51134548
87detection of temperature stimulus (GO:0016048)2.51087797
88mitotic metaphase plate congression (GO:0007080)2.50170943
89retinal ganglion cell axon guidance (GO:0031290)2.50152298
90axon extension (GO:0048675)2.49502100
91negative regulation of DNA-dependent DNA replication (GO:2000104)2.48211206
92glutamate secretion (GO:0014047)2.47090495
93regulation of helicase activity (GO:0051095)2.47000663
94regulation of cardiac muscle cell apoptotic process (GO:0010665)2.46362191
95mitotic spindle checkpoint (GO:0071174)2.45745853
96neuromuscular synaptic transmission (GO:0007274)2.43908593
97postsynaptic membrane organization (GO:0001941)2.43275874
98pyrimidine nucleobase catabolic process (GO:0006208)2.43220249
99DNA replication checkpoint (GO:0000076)2.43121587
100spindle checkpoint (GO:0031577)2.42930329
101innervation (GO:0060384)2.42402669
102DNA replication-dependent nucleosome organization (GO:0034723)2.42391918
103DNA replication-dependent nucleosome assembly (GO:0006335)2.42391918
104axon cargo transport (GO:0008088)2.41941490
105spliceosomal snRNP assembly (GO:0000387)2.40818161
106regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.40778901
107transferrin transport (GO:0033572)2.40766788
108cerebral cortex radially oriented cell migration (GO:0021799)2.40696639
109amino acid activation (GO:0043038)2.40449230
110tRNA aminoacylation (GO:0043039)2.40449230
111sequestering of actin monomers (GO:0042989)2.39888402
112positive regulation of protein complex disassembly (GO:0043243)2.39503971
113tRNA aminoacylation for protein translation (GO:0006418)2.39320850
114establishment of melanosome localization (GO:0032401)2.38974159
115regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.38866454
116transmission of nerve impulse (GO:0019226)2.38322167
117protein K48-linked ubiquitination (GO:0070936)2.38106364
118organelle transport along microtubule (GO:0072384)2.37875285
119energy coupled proton transport, down electrochemical gradient (GO:0015985)2.37623539
120ATP synthesis coupled proton transport (GO:0015986)2.37623539
121regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.37318249
122regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.36824071
123regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.36704241
124serotonin receptor signaling pathway (GO:0007210)2.36331592
125somatic diversification of immune receptors via somatic mutation (GO:0002566)2.36281289
126somatic hypermutation of immunoglobulin genes (GO:0016446)2.36281289
127formation of translation preinitiation complex (GO:0001731)2.36142011
128negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.35851758
129negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.35851758
130negative regulation of mitotic sister chromatid segregation (GO:0033048)2.35851758
131negative regulation of mitotic sister chromatid separation (GO:2000816)2.35851758
132negative regulation of sister chromatid segregation (GO:0033046)2.35851758
133ubiquinone metabolic process (GO:0006743)2.35160316
134nonmotile primary cilium assembly (GO:0035058)2.34757138
135regulation of acyl-CoA biosynthetic process (GO:0050812)2.34386913
136ribosome assembly (GO:0042255)2.34281272
137ventricular trabecula myocardium morphogenesis (GO:0003222)2.34221187
138negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.33879712
139regulation of mitochondrial translation (GO:0070129)2.33581838
140muscle cell cellular homeostasis (GO:0046716)2.33381822
141dendrite development (GO:0016358)2.33164361
142negative regulation of striated muscle cell apoptotic process (GO:0010664)2.32507102
143adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.32499440
144negative regulation of calcium ion transport into cytosol (GO:0010523)2.31878105
145regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.31218121
146axonal fasciculation (GO:0007413)2.28691000
147spinal cord development (GO:0021510)2.27645763
148vesicle transport along microtubule (GO:0047496)2.27169843
149synaptic vesicle endocytosis (GO:0048488)2.26857404
150neuron projection extension (GO:1990138)2.25638614
151positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.24788841
152membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.24678574
153neuron fate specification (GO:0048665)2.23269123
154regulation of neuronal synaptic plasticity (GO:0048168)2.22158283
155peptidyl-arginine N-methylation (GO:0035246)2.20931641
156peptidyl-arginine methylation (GO:0018216)2.20931641
157positive regulation of axon extension (GO:0045773)2.20554568
158synapse assembly (GO:0007416)2.19281974
159ribonucleoprotein complex disassembly (GO:0032988)2.18481316
160membrane depolarization during action potential (GO:0086010)2.17480552
161establishment of vesicle localization (GO:0051650)2.16966385
162superoxide anion generation (GO:0042554)2.16900831
163histone arginine methylation (GO:0034969)2.16375837
164regulation of platelet aggregation (GO:0090330)2.15222361
165trivalent inorganic cation transport (GO:0072512)2.14545080
166ferric iron transport (GO:0015682)2.14545080
167regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.13803118
168cullin deneddylation (GO:0010388)2.13179321
169positive regulation of response to oxidative stress (GO:1902884)2.11625071
170positive regulation of cellular response to oxidative stress (GO:1900409)2.11625071
171negative regulation of synaptic transmission, GABAergic (GO:0032229)2.11375854
172membrane budding (GO:0006900)2.10664862
173regulation of glutamate receptor signaling pathway (GO:1900449)2.09771799
174peptidyl-arginine omega-N-methylation (GO:0035247)2.09451899
175cytoskeleton-dependent intracellular transport (GO:0030705)2.08534695
176anterograde axon cargo transport (GO:0008089)2.08284840
177membrane assembly (GO:0071709)2.08180039
178regulation of cAMP-dependent protein kinase activity (GO:2000479)2.08115325
179negative regulation of cation channel activity (GO:2001258)2.08100114
180regulation of vesicle fusion (GO:0031338)2.08088275
181melanosome transport (GO:0032402)2.07935898
182regulation of dendrite morphogenesis (GO:0048814)2.07613612
183detection of mechanical stimulus involved in sensory perception (GO:0050974)2.07410268
184action potential (GO:0001508)2.06835973

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.91404806
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.58050015
3GBX2_23144817_ChIP-Seq_PC3_Human3.38833773
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.21721045
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.11653731
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.75870924
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.60487619
8IGF1R_20145208_ChIP-Seq_DFB_Human2.60385223
9ZNF274_21170338_ChIP-Seq_K562_Hela2.54000471
10ELK1_19687146_ChIP-ChIP_HELA_Human2.50119701
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.47037579
12TAF15_26573619_Chip-Seq_HEK293_Human2.43316746
13BMI1_23680149_ChIP-Seq_NPCS_Mouse2.33490307
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.29824625
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.27381422
16VDR_22108803_ChIP-Seq_LS180_Human2.19038156
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.18453288
18* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.17619445
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.15778900
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.14412924
21RBPJ_22232070_ChIP-Seq_NCS_Mouse2.13292880
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.12261947
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.11625615
24SMAD_19615063_ChIP-ChIP_OVARY_Human2.10922763
25ZFP57_27257070_Chip-Seq_ESCs_Mouse2.10748737
26VDR_23849224_ChIP-Seq_CD4+_Human1.97104637
27* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.95956788
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.93697569
29RNF2_27304074_Chip-Seq_NSC_Mouse1.90266543
30JARID2_20075857_ChIP-Seq_MESCs_Mouse1.87174302
31MYC_18555785_ChIP-Seq_MESCs_Mouse1.85886299
32SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.85249455
33HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.84431909
34JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.84083272
35EZH2_18974828_ChIP-Seq_MESCs_Mouse1.81601884
36RNF2_18974828_ChIP-Seq_MESCs_Mouse1.81601884
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.80253503
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80080356
39* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.79984474
40NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.78117665
41PADI4_21655091_ChIP-ChIP_MCF-7_Human1.76407398
42* P300_19829295_ChIP-Seq_ESCs_Human1.76096197
43WT1_19549856_ChIP-ChIP_CCG9911_Human1.74541126
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.74423055
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73406057
46SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.73396282
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.72810742
48HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.70962929
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.69888789
50SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.69783584
51EED_16625203_ChIP-ChIP_MESCs_Mouse1.69143229
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69080704
53REST_21632747_ChIP-Seq_MESCs_Mouse1.68231449
54* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.65263893
55AR_21572438_ChIP-Seq_LNCaP_Human1.62858840
56RNF2_27304074_Chip-Seq_ESCs_Mouse1.60145428
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59817875
58MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.58275214
59E2F7_22180533_ChIP-Seq_HELA_Human1.57997409
60PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.56497493
61SMAD4_21799915_ChIP-Seq_A2780_Human1.56047302
62SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55094112
63DCP1A_22483619_ChIP-Seq_HELA_Human1.54850001
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.53029093
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.52507402
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.49059577
67FOXP3_21729870_ChIP-Seq_TREG_Human1.48556580
68GABP_19822575_ChIP-Seq_HepG2_Human1.48229686
69HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.48054263
70* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.45525604
71E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.45446028
72* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45176010
73EZH2_27294783_Chip-Seq_ESCs_Mouse1.44955761
74SALL1_21062744_ChIP-ChIP_HESCs_Human1.42698488
75IRF1_19129219_ChIP-ChIP_H3396_Human1.38977385
76SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.38807266
77SUZ12_27294783_Chip-Seq_ESCs_Mouse1.37398857
78SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.37155986
79MYC_18940864_ChIP-ChIP_HL60_Human1.35409041
80CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34210790
81TTF2_22483619_ChIP-Seq_HELA_Human1.33407766
82FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.32575933
83BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.32318340
84MTF2_20144788_ChIP-Seq_MESCs_Mouse1.32236580
85* REST_18959480_ChIP-ChIP_MESCs_Mouse1.30261842
86RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30180659
87MYC_19030024_ChIP-ChIP_MESCs_Mouse1.30166886
88POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.29949057
89ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.29798499
90MYCN_18555785_ChIP-Seq_MESCs_Mouse1.29760802
91GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.29406980
92ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28742609
93NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27872864
94RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.25601420
95HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22679115
96FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.21887848
97NANOG_16153702_ChIP-ChIP_HESCs_Human1.21325711
98JUN_21703547_ChIP-Seq_K562_Human1.21224556
99PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.21213136
100SMAD3_21741376_ChIP-Seq_EPCs_Human1.20377256
101* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.20113064
102E2F1_18555785_ChIP-Seq_MESCs_Mouse1.20058596
103PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.18385777
104SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17896562
105* AHR_22903824_ChIP-Seq_MCF-7_Human1.17571220
106NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.15296838
107ER_23166858_ChIP-Seq_MCF-7_Human1.14727954
108FUS_26573619_Chip-Seq_HEK293_Human1.14687587
109SRF_21415370_ChIP-Seq_HL-1_Mouse1.13045279
110SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12023643
111PRDM14_20953172_ChIP-Seq_ESCs_Human1.11642876
112TP53_18474530_ChIP-ChIP_U2OS_Human1.11483277
113STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.11391152
114TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.10641932
115TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.10582036
116PIAS1_25552417_ChIP-Seq_VCAP_Human1.10391771
117EWS_26573619_Chip-Seq_HEK293_Human1.10039893
118FLI1_27457419_Chip-Seq_LIVER_Mouse1.10017071
119STAT3_23295773_ChIP-Seq_U87_Human1.09259538
120MYC_18358816_ChIP-ChIP_MESCs_Mouse1.08491850
121SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.07828698
122CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07236074
123MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06771439
124* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06622552
125TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05995805
126XRN2_22483619_ChIP-Seq_HELA_Human1.05128339
127TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04248592
128UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04119343
129RING1B_27294783_Chip-Seq_NPCs_Mouse1.04116398
130P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03495911
131MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.03262366
132CBP_20019798_ChIP-Seq_JUKART_Human1.02269299
133IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02269299
134AR_25329375_ChIP-Seq_VCAP_Human1.01396396
135E2F1_18555785_Chip-Seq_ESCs_Mouse1.01260146
136KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01249464
137CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00798859
138SOX2_21211035_ChIP-Seq_LN229_Gbm0.99730318
139SOX9_26525672_Chip-Seq_HEART_Mouse0.99392987
140SOX2_16153702_ChIP-ChIP_HESCs_Human0.99170995
141TP53_22573176_ChIP-Seq_HFKS_Human0.99156817
142KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98372348
143AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97959920
144RARB_27405468_Chip-Seq_BRAIN_Mouse0.97791888
145RUNX2_22187159_ChIP-Seq_PCA_Human0.97491488
146* REST_19997604_ChIP-ChIP_NEURONS_Mouse0.97396401
147* ARNT_22903824_ChIP-Seq_MCF-7_Human0.96486790
148PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95602905
149YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95448230
150ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94821583
151NOTCH1_21737748_ChIP-Seq_TLL_Human0.94499979
152CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.94281474
153GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93983218
154NANOG_18555785_Chip-Seq_ESCs_Mouse0.93132534
155ZFX_18555785_ChIP-Seq_MESCs_Mouse0.92755503
156POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92677603
157VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.92377879
158EZH2_27294783_Chip-Seq_NPCs_Mouse0.91691591
159MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90305625
160SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89636282
161TP53_20018659_ChIP-ChIP_R1E_Mouse0.89230566
162ZFP281_18757296_ChIP-ChIP_E14_Mouse0.88913693
163RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.85361382

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002735_abnormal_chemical_nociception3.97732548
2MP0004270_analgesia3.68755371
3MP0003880_abnormal_central_pattern3.54660820
4MP0006276_abnormal_autonomic_nervous3.13687495
5MP0008877_abnormal_DNA_methylation2.97741859
6MP0002734_abnormal_mechanical_nocicepti2.62593317
7MP0001968_abnormal_touch/_nociception2.58420914
8MP0002102_abnormal_ear_morphology2.52438169
9MP0004859_abnormal_synaptic_plasticity2.47626570
10MP0008058_abnormal_DNA_repair2.44015605
11MP0002822_catalepsy2.35936565
12MP0002751_abnormal_autonomic_nervous2.32632266
13MP0003890_abnormal_embryonic-extraembry2.27642282
14MP0004858_abnormal_nervous_system2.21121327
15MP0002184_abnormal_innervation2.19912347
16MP0002234_abnormal_pharynx_morphology2.19888334
17MP0002736_abnormal_nociception_after2.17917202
18MP0001188_hyperpigmentation2.02736270
19MP0005645_abnormal_hypothalamus_physiol2.02213088
20MP0003635_abnormal_synaptic_transmissio2.01268544
21MP0000778_abnormal_nervous_system1.98349121
22MP0000015_abnormal_ear_pigmentation1.95679528
23MP0002733_abnormal_thermal_nociception1.94780713
24MP0009046_muscle_twitch1.92540138
25MP0003787_abnormal_imprinting1.84645368
26MP0005171_absent_coat_pigmentation1.83766505
27MP0000372_irregular_coat_pigmentation1.80314572
28MP0002063_abnormal_learning/memory/cond1.77938805
29MP0001970_abnormal_pain_threshold1.77329282
30MP0009745_abnormal_behavioral_response1.68070195
31MP0006035_abnormal_mitochondrial_morpho1.66396932
32MP0008789_abnormal_olfactory_epithelium1.58960758
33MP0004957_abnormal_blastocyst_morpholog1.55164659
34MP0010094_abnormal_chromosome_stability1.54462989
35MP0002272_abnormal_nervous_system1.53069841
36MP0003646_muscle_fatigue1.51303972
37MP0002837_dystrophic_cardiac_calcinosis1.48058624
38MP0008932_abnormal_embryonic_tissue1.47384939
39MP0002067_abnormal_sensory_capabilities1.47155646
40MP0004811_abnormal_neuron_physiology1.46944241
41MP0003693_abnormal_embryo_hatching1.46826627
42MP0005423_abnormal_somatic_nervous1.46710059
43MP0002638_abnormal_pupillary_reflex1.45948053
44MP0000569_abnormal_digit_pigmentation1.45726423
45MP0005187_abnormal_penis_morphology1.43102591
46MP0001293_anophthalmia1.42862617
47MP0002064_seizures1.42518357
48MP0005394_taste/olfaction_phenotype1.42093440
49MP0005499_abnormal_olfactory_system1.42093440
50MP0001348_abnormal_lacrimal_gland1.40716914
51MP0001984_abnormal_olfaction1.39551681
52MP0001529_abnormal_vocalization1.39460481
53MP0003567_abnormal_fetal_cardiomyocyte1.38960554
54MP0001986_abnormal_taste_sensitivity1.38011242
55MP0003119_abnormal_digestive_system1.37891062
56MP0002233_abnormal_nose_morphology1.36555094
57MP0002572_abnormal_emotion/affect_behav1.35068584
58MP0010386_abnormal_urinary_bladder1.34656210
59MP0003122_maternal_imprinting1.34221299
60MP0000955_abnormal_spinal_cord1.32222270
61MP0002163_abnormal_gland_morphology1.27275980
62MP0008057_abnormal_DNA_replication1.26409763
63MP0000049_abnormal_middle_ear1.23767609
64MP0002882_abnormal_neuron_morphology1.23304691
65MP0000647_abnormal_sebaceous_gland1.20645322
66MP0003077_abnormal_cell_cycle1.20582824
67MP0003937_abnormal_limbs/digits/tail_de1.17838008
68MP0003111_abnormal_nucleus_morphology1.17753810
69MP0006292_abnormal_olfactory_placode1.17078401
70MP0005248_abnormal_Harderian_gland1.17025896
71MP0003121_genomic_imprinting1.14949696
72MP0002653_abnormal_ependyma_morphology1.11802208
73MP0002752_abnormal_somatic_nervous1.09398948
74MP0004924_abnormal_behavior1.08526643
75MP0005386_behavior/neurological_phenoty1.08526643
76MP0001486_abnormal_startle_reflex1.07584394
77MP0002332_abnormal_exercise_endurance1.04394654
78MP0004742_abnormal_vestibular_system1.04061946
79MP0003718_maternal_effect1.03096382
80MP0002090_abnormal_vision1.02675512
81MP0003941_abnormal_skin_development1.02401862
82MP0005623_abnormal_meninges_morphology1.02169768
83MP0002557_abnormal_social/conspecific_i0.99221412
84MP0004233_abnormal_muscle_weight0.98908802
85MP0001286_abnormal_eye_development0.98521700
86MP0002972_abnormal_cardiac_muscle0.94150909
87MP0001299_abnormal_eye_distance/0.93574023
88MP0004084_abnormal_cardiac_muscle0.93537421
89MP0002877_abnormal_melanocyte_morpholog0.93218427
90MP0003136_yellow_coat_color0.93082393
91MP0002084_abnormal_developmental_patter0.92642971
92MP0001440_abnormal_grooming_behavior0.90787936
93MP0000358_abnormal_cell_content/0.90026969
94MP0001963_abnormal_hearing_physiology0.89160239
95MP0002697_abnormal_eye_size0.89042165
96MP0000631_abnormal_neuroendocrine_gland0.89005218
97MP0004145_abnormal_muscle_electrophysio0.88952473
98MP0005367_renal/urinary_system_phenotyp0.87680918
99MP0000516_abnormal_urinary_system0.87680918
100MP0009697_abnormal_copulation0.87531379
101MP0005391_vision/eye_phenotype0.86617258
102MP0008995_early_reproductive_senescence0.85762112
103MP0005646_abnormal_pituitary_gland0.85412545
104MP0003861_abnormal_nervous_system0.84738804
105MP0002066_abnormal_motor_capabilities/c0.84480979
106MP0004197_abnormal_fetal_growth/weight/0.84065782
107MP0000751_myopathy0.83077817
108MP0004085_abnormal_heartbeat0.83025241
109MP0008007_abnormal_cellular_replicative0.82951198
110MP0000750_abnormal_muscle_regeneration0.82296048
111MP0004133_heterotaxia0.81548044
112MP0002160_abnormal_reproductive_system0.81522972
113MP0002152_abnormal_brain_morphology0.81422690
114MP0006036_abnormal_mitochondrial_physio0.81412531
115MP0000026_abnormal_inner_ear0.80470238
116MP0004147_increased_porphyrin_level0.80273263
117MP0002009_preneoplasia0.77392151
118MP0000538_abnormal_urinary_bladder0.76116006
119MP0003123_paternal_imprinting0.75063645
120MP0008569_lethality_at_weaning0.72907155
121MP0004215_abnormal_myocardial_fiber0.71398585
122MP0003385_abnormal_body_wall0.71173564
123MP0004484_altered_response_of0.69606323
124MP0001905_abnormal_dopamine_level0.69447628
125MP0003755_abnormal_palate_morphology0.69334306
126MP0000749_muscle_degeneration0.67622174
127MP0004142_abnormal_muscle_tone0.67454543
128MP0003221_abnormal_cardiomyocyte_apopto0.66174496
129MP0002229_neurodegeneration0.65986612
130MP0002177_abnormal_outer_ear0.64608662
131MP0001542_abnormal_bone_strength0.63080479
132MP0003315_abnormal_perineum_morphology0.62714347
133MP0006072_abnormal_retinal_apoptosis0.62370854
134MP0003137_abnormal_impulse_conducting0.62129974
135MP0008260_abnormal_autophagy0.61751816
136MP0002081_perinatal_lethality0.61382092
137MP0005620_abnormal_muscle_contractility0.60934567
138MP0005253_abnormal_eye_physiology0.60880293
139MP0008775_abnormal_heart_ventricle0.59274119
140MP0003634_abnormal_glial_cell0.58981823
141MP0001177_atelectasis0.58740342
142MP0001943_abnormal_respiration0.56641219

Predicted human phenotypes

RankGene SetZ-score
1Cortical dysplasia (HP:0002539)4.72243266
2Ulnar claw (HP:0001178)3.71490419
3Febrile seizures (HP:0002373)3.62636209
4Fetal akinesia sequence (HP:0001989)3.36321646
5Hypothermia (HP:0002045)3.27940693
6Myokymia (HP:0002411)3.23054165
7Atonic seizures (HP:0010819)3.12988191
8Amyotrophic lateral sclerosis (HP:0007354)3.10544756
9Focal motor seizures (HP:0011153)3.06142208
10Acute necrotizing encephalopathy (HP:0006965)3.01327402
11Abnormality of the musculature of the pelvis (HP:0001469)2.95571077
12Abnormality of the hip-girdle musculature (HP:0001445)2.95571077
13Curly hair (HP:0002212)2.89601707
14Drooling (HP:0002307)2.82310069
15Failure to thrive in infancy (HP:0001531)2.79135849
16Pheochromocytoma (HP:0002666)2.77835316
17Progressive cerebellar ataxia (HP:0002073)2.73943352
18Abnormal hair whorl (HP:0010721)2.72643248
19Thyroid carcinoma (HP:0002890)2.67019664
20Neuroendocrine neoplasm (HP:0100634)2.63633236
21Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.61717711
22Abnormality of alanine metabolism (HP:0010916)2.61717711
23Hyperalaninemia (HP:0003348)2.61717711
24Abnormal mitochondria in muscle tissue (HP:0008316)2.60605426
25Progressive macrocephaly (HP:0004481)2.58155661
26Excessive salivation (HP:0003781)2.55987471
27Focal seizures (HP:0007359)2.54466510
28Limb dystonia (HP:0002451)2.52785471
29Acute encephalopathy (HP:0006846)2.52782674
30Epileptic encephalopathy (HP:0200134)2.50511854
31Increased CSF lactate (HP:0002490)2.48201971
32Agnosia (HP:0010524)2.45229543
33Mitochondrial inheritance (HP:0001427)2.43201029
34Medulloblastoma (HP:0002885)2.40767690
35Exercise-induced muscle cramps (HP:0003710)2.39588722
36Increased hepatocellular lipid droplets (HP:0006565)2.38509796
37Poor suck (HP:0002033)2.33247231
38Heterochromia iridis (HP:0001100)2.31652214
39Abnormality of the corticospinal tract (HP:0002492)2.30602801
40Asymmetry of the thorax (HP:0001555)2.29281258
41Bradycardia (HP:0001662)2.28559752
42Pelvic girdle muscle weakness (HP:0003749)2.27834877
43Postnatal microcephaly (HP:0005484)2.26004033
44Amblyopia (HP:0000646)2.24577899
45Distal lower limb muscle weakness (HP:0009053)2.23913454
46Rimmed vacuoles (HP:0003805)2.22722990
47Steppage gait (HP:0003376)2.21900460
48Akinesia (HP:0002304)2.20739851
493-Methylglutaconic aciduria (HP:0003535)2.20415749
50Pancreatic cysts (HP:0001737)2.20316871
51Abnormality of the labia minora (HP:0012880)2.18739780
52Polyphagia (HP:0002591)2.17614697
53Absence seizures (HP:0002121)2.14509544
54Gait imbalance (HP:0002141)2.14503676
55Retinal dysplasia (HP:0007973)2.14171652
56Lipid accumulation in hepatocytes (HP:0006561)2.13353571
57Septo-optic dysplasia (HP:0100842)2.12767939
58Pancreatic fibrosis (HP:0100732)2.12246200
59Degeneration of anterior horn cells (HP:0002398)2.11696621
60Abnormality of the anterior horn cell (HP:0006802)2.11696621
61Increased serum pyruvate (HP:0003542)2.08970003
62Impaired vibration sensation in the lower limbs (HP:0002166)2.08680765
63Visual hallucinations (HP:0002367)2.06136075
64Dysautonomia (HP:0002459)2.06049277
65Abnormality of the lower motor neuron (HP:0002366)2.05155257
66Sleep apnea (HP:0010535)2.03781108
67Ankle clonus (HP:0011448)2.03378213
68Abnormality of the vocal cords (HP:0008777)2.01926903
69Pachygyria (HP:0001302)2.01038773
70Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.00954128
71Degeneration of the lateral corticospinal tracts (HP:0002314)2.00954128
72Lower limb amyotrophy (HP:0007210)2.00798805
73Vaginal atresia (HP:0000148)2.00179514
74Hepatocellular necrosis (HP:0001404)1.99899127
75Colon cancer (HP:0003003)1.99723480
76Microvesicular hepatic steatosis (HP:0001414)1.95776297
77Papillary thyroid carcinoma (HP:0002895)1.95350880
78Foot dorsiflexor weakness (HP:0009027)1.95184111
79Supranuclear gaze palsy (HP:0000605)1.94976682
80Cerebral hypomyelination (HP:0006808)1.94642860
81Upper limb muscle weakness (HP:0003484)1.93870476
82Action tremor (HP:0002345)1.92839084
83Poor coordination (HP:0002370)1.92754571
84Abnormal autonomic nervous system physiology (HP:0012332)1.91927212
85Abnormality of midbrain morphology (HP:0002418)1.89482570
86Molar tooth sign on MRI (HP:0002419)1.89482570
87Abnormality of the metopic suture (HP:0005556)1.88923028
88Abnormality of glycolysis (HP:0004366)1.88716637
89Generalized tonic-clonic seizures (HP:0002069)1.88102437
90Volvulus (HP:0002580)1.86532850
91Distal lower limb amyotrophy (HP:0008944)1.86397198
92Dialeptic seizures (HP:0011146)1.86086876
93Hepatic necrosis (HP:0002605)1.85415475
94Cerebral edema (HP:0002181)1.85270619
95Segmental peripheral demyelination/remyelination (HP:0003481)1.84042679
96Abnormality of the foot musculature (HP:0001436)1.82872364
97Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.81685647
98Muscle fibrillation (HP:0010546)1.80950767
99Aplasia/Hypoplasia of the brainstem (HP:0007362)1.80564439
100Hypoplasia of the brainstem (HP:0002365)1.80564439
101Lower limb muscle weakness (HP:0007340)1.79659563
102Decreased testicular size (HP:0008734)1.79227383
103Congenital primary aphakia (HP:0007707)1.79087434
104Methylmalonic acidemia (HP:0002912)1.79035478
105Hypercortisolism (HP:0001578)1.78945270
106Cystic hygroma (HP:0000476)1.78922504
107Optic nerve hypoplasia (HP:0000609)1.77324045
108Specific learning disability (HP:0001328)1.77277072
109Broad foot (HP:0001769)1.77123517
110Tongue fasciculations (HP:0001308)1.77029450
111Abnormality of pain sensation (HP:0010832)1.76549914
112Impaired pain sensation (HP:0007328)1.76549914
113Neoplasm of the peripheral nervous system (HP:0100007)1.76209105
114Nephrogenic diabetes insipidus (HP:0009806)1.76095710
115Autoamputation (HP:0001218)1.75502574
116Cutaneous melanoma (HP:0012056)1.74807193
117Hypoventilation (HP:0002791)1.74464810
118Increased serum lactate (HP:0002151)1.73754109
119Muscular hypotonia of the trunk (HP:0008936)1.73665671
120Lissencephaly (HP:0001339)1.72559469
121Aqueductal stenosis (HP:0002410)1.72521826
122Shoulder girdle muscle weakness (HP:0003547)1.72352144
123Micropenis (HP:0000054)1.71502331
124Neoplasm of the adrenal cortex (HP:0100641)1.70603537
125Medial flaring of the eyebrow (HP:0010747)1.69994845
126Irregular epiphyses (HP:0010582)1.69461416
127Spastic tetraplegia (HP:0002510)1.69226349
128Popliteal pterygium (HP:0009756)1.68577142
129Hepatoblastoma (HP:0002884)1.67663961
130Bifid tongue (HP:0010297)1.67582303
131Leukodystrophy (HP:0002415)1.67406060
132Lactic acidosis (HP:0003128)1.66770841
133Labial hypoplasia (HP:0000066)1.66210988
134Chromosomal breakage induced by crosslinking agents (HP:0003221)1.65881671
135Insidious onset (HP:0003587)1.65845699
136Termporal pattern (HP:0011008)1.65845699
137Hypsarrhythmia (HP:0002521)1.65533588
138Esotropia (HP:0000565)1.65378219
139Polymicrogyria (HP:0002126)1.65251366
140Oligodactyly (hands) (HP:0001180)1.65199792
141Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.64706205
142Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.64543616
143Wrist flexion contracture (HP:0001239)1.64112241
144Broad-based gait (HP:0002136)1.63734198
145Abnormal lung lobation (HP:0002101)1.63299107
146Prominent metopic ridge (HP:0005487)1.62908680
147Exotropia (HP:0000577)1.62838308
148Inappropriate behavior (HP:0000719)1.62697292
149Hypoplastic female external genitalia (HP:0012815)1.62604235
150Oculomotor apraxia (HP:0000657)1.62344163
151Chorioretinal coloboma (HP:0000567)1.62009437
152Growth hormone deficiency (HP:0000824)1.61463112
153Protruding tongue (HP:0010808)1.60548439
154Atrial fibrillation (HP:0005110)1.59702845
155Abnormality of the nasal septum (HP:0000419)1.59148524
156Orthostatic hypotension (HP:0001278)1.58704048
157Distal sensory impairment (HP:0002936)1.57348823
158Submucous cleft hard palate (HP:0000176)1.56909296
159Decreased motor nerve conduction velocity (HP:0003431)1.56666571
160Atrophy/Degeneration involving motor neurons (HP:0007373)1.54605767
161Primary atrial arrhythmia (HP:0001692)1.54368041
162Meningioma (HP:0002858)1.54344996
163Anhidrosis (HP:0000970)1.53398608
164Urinary urgency (HP:0000012)1.53068291
165Absent frontal sinuses (HP:0002688)1.50934246
166Intestinal atresia (HP:0011100)1.50802011
167Choroideremia (HP:0001139)1.50477463
168Genital tract atresia (HP:0001827)1.50246291
169Abnormality of the septum pellucidum (HP:0007375)1.49756394

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.29581770
2TRIM284.07813207
3MARK13.21705800
4MINK13.13330768
5ERBB32.81229314
6SIK32.69225645
7CDK192.51602281
8BCR2.48601865
9MAP4K22.37519162
10MAP3K122.33485231
11MAP3K142.27243665
12PLK22.27227528
13NTRK32.21982503
14PRPF4B2.20648662
15LIMK12.07909636
16DYRK32.02886698
17MAPK131.99910724
18ZAK1.83288429
19ARAF1.80662515
20AKT31.80555512
21YES11.76125028
22DYRK21.76090089
23CSNK1G21.69315973
24MAP2K71.68461150
25BMPR1B1.65860244
26SGK21.53787598
27GRK71.51925244
28MAP3K41.44659312
29MKNK21.44486630
30TNIK1.44204989
31KSR11.43510658
32BMPR21.42507856
33LATS21.42506204
34CSNK1G31.42359035
35PLK31.40736179
36PIM21.36043442
37CDC71.34488089
38RPS6KA41.31606224
39CSNK1G11.30513490
40CSNK1A1L1.30413601
41CCNB11.28522756
42SGK4941.27500874
43SGK2231.27500874
44NTRK11.25603393
45BUB11.25070207
46SCYL21.23482494
47STK241.21526320
48EPHA31.18515697
49PINK11.17479059
50MKNK11.13560518
51PLK41.13453135
52MAP3K91.12493970
53STK161.10742447
54PHKG21.09230597
55PHKG11.09230597
56STK38L0.99700744
57TTK0.97940159
58EIF2AK30.96239509
59EIF2AK20.94599962
60MAPKAPK30.93250446
61GRK50.91044799
62MAP3K60.90501405
63FER0.89556828
64BRAF0.86804876
65UHMK10.86379372
66WEE10.86289612
67RIPK40.85590544
68PRKCE0.82333961
69PLK10.81470234
70SGK30.81218378
71EPHB20.80699479
72PNCK0.80270235
73DYRK1B0.77704482
74PAK60.76598634
75BRD40.74582275
76RPS6KA20.74090342
77CDK50.72849603
78EIF2AK10.72294817
79NEK60.71267602
80MATK0.71132320
81TSSK60.69842369
82MAP2K10.69806027
83CDK140.69111039
84WNK30.69037315
85SRPK10.68829676
86AURKA0.68462401
87MUSK0.64530723
88MST40.63969705
89BRSK20.62735527
90CDK180.62315922
91NUAK10.60448282
92CHEK20.59601162
93TESK10.59068217
94CAMK2A0.58870437
95EPHA40.58769678
96ADRBK20.58091793
97WNK40.56960810
98MAP2K40.56609172
99PBK0.56263075
100TRPM70.54848961
101PRKCG0.54206930
102OBSCN0.53452060
103STK390.53324006
104DYRK1A0.50114974
105BCKDK0.49436941
106BLK0.48967145
107ROCK10.48546617
108CSNK1E0.47691949
109NEK10.45808068
110ADRBK10.45467647
111CAMK40.44782547
112ATM0.44760037
113PAK30.44577214
114ACVR1B0.44454492
115SIK20.43544582
116BRSK10.43174203
117MAP3K130.42967445
118CDK150.42317547
119MAP3K50.42303735
120NTRK20.41743165
121CHEK10.40745492
122ROCK20.39266882
123OXSR10.38334021
124CAMKK20.36912484
125DAPK10.36712187
126CDK11A0.36559413
127PDK20.36413206
128AURKB0.36245046
129CSNK2A20.35108143
130CDK30.35100227
131SGK10.35059244
132PRKACB0.34815133
133ATR0.34760344
134RPS6KA50.34690182
135EGFR0.34349152
136ALK0.33751444
137STK30.33282537
138CAMK2B0.33046791
139RAF10.32832642
140VRK10.32733649
141PKN10.31646821
142DAPK20.31317674
143PRKCH0.31158706
144LMTK20.30614269
145RPS6KB10.29549121
146MARK30.27899888
147WNK10.27463632
148MAPK80.26647711
149IRAK20.26413554
150RPS6KC10.26197353
151RPS6KL10.26197353
152IRAK10.24283252

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.69401277
2Synaptic vesicle cycle_Homo sapiens_hsa047212.75220687
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.32037360
4RNA transport_Homo sapiens_hsa030132.29797638
5Spliceosome_Homo sapiens_hsa030402.23693608
6Steroid biosynthesis_Homo sapiens_hsa001002.18690383
7Basal transcription factors_Homo sapiens_hsa030222.18454835
8Non-homologous end-joining_Homo sapiens_hsa034502.07283739
9RNA degradation_Homo sapiens_hsa030181.87198637
10Olfactory transduction_Homo sapiens_hsa047401.85704446
11Collecting duct acid secretion_Homo sapiens_hsa049661.85677591
12Nicotine addiction_Homo sapiens_hsa050331.81835199
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.80347138
14Phototransduction_Homo sapiens_hsa047441.76936597
15Regulation of autophagy_Homo sapiens_hsa041401.73843824
16mRNA surveillance pathway_Homo sapiens_hsa030151.72349393
17Mismatch repair_Homo sapiens_hsa034301.71055217
18Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.60595749
19Proteasome_Homo sapiens_hsa030501.59038992
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.54988254
21Dopaminergic synapse_Homo sapiens_hsa047281.52026398
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45889899
23Serotonergic synapse_Homo sapiens_hsa047261.45050100
24Vibrio cholerae infection_Homo sapiens_hsa051101.43907862
25Cell cycle_Homo sapiens_hsa041101.36237079
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.34899571
27Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.33385817
28Axon guidance_Homo sapiens_hsa043601.32588588
29Cholinergic synapse_Homo sapiens_hsa047251.32253112
30Long-term potentiation_Homo sapiens_hsa047201.32132419
31Fanconi anemia pathway_Homo sapiens_hsa034601.31979645
32DNA replication_Homo sapiens_hsa030301.28917276
33* Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.28537378
34Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.28260497
35Fatty acid elongation_Homo sapiens_hsa000621.26908543
36Nucleotide excision repair_Homo sapiens_hsa034201.26863070
37Circadian entrainment_Homo sapiens_hsa047131.26207841
38Morphine addiction_Homo sapiens_hsa050321.23772678
39Propanoate metabolism_Homo sapiens_hsa006401.22288858
40Rheumatoid arthritis_Homo sapiens_hsa053231.19493099
41Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.19422461
42Taste transduction_Homo sapiens_hsa047421.19396595
43Pyrimidine metabolism_Homo sapiens_hsa002401.19086053
44* Phagosome_Homo sapiens_hsa041451.18935251
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.17427335
46ErbB signaling pathway_Homo sapiens_hsa040121.15389697
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.14189884
48GABAergic synapse_Homo sapiens_hsa047271.11151592
49Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.10320853
50Neurotrophin signaling pathway_Homo sapiens_hsa047221.08085816
51Type I diabetes mellitus_Homo sapiens_hsa049401.08015245
52Amphetamine addiction_Homo sapiens_hsa050311.07551329
53* Salmonella infection_Homo sapiens_hsa051321.07266353
54Cardiac muscle contraction_Homo sapiens_hsa042601.06469420
55SNARE interactions in vesicular transport_Homo sapiens_hsa041301.02256182
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.02112469
57Homologous recombination_Homo sapiens_hsa034401.00758498
58Oxidative phosphorylation_Homo sapiens_hsa001901.00637173
59Glutamatergic synapse_Homo sapiens_hsa047241.00125937
60Base excision repair_Homo sapiens_hsa034100.99519696
61Oocyte meiosis_Homo sapiens_hsa041140.98758237
62Ribosome_Homo sapiens_hsa030100.97487607
63Endometrial cancer_Homo sapiens_hsa052130.96900436
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95785388
65Graft-versus-host disease_Homo sapiens_hsa053320.92467277
66Melanoma_Homo sapiens_hsa052180.91326462
67Long-term depression_Homo sapiens_hsa047300.90570178
68Butanoate metabolism_Homo sapiens_hsa006500.88912863
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88050902
70Allograft rejection_Homo sapiens_hsa053300.87844337
71Parkinsons disease_Homo sapiens_hsa050120.87232612
722-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.86993338
73Dilated cardiomyopathy_Homo sapiens_hsa054140.86360222
74Oxytocin signaling pathway_Homo sapiens_hsa049210.86216173
75Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.86083445
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85576183
77Shigellosis_Homo sapiens_hsa051310.85401723
78Glioma_Homo sapiens_hsa052140.84811880
79Gap junction_Homo sapiens_hsa045400.82421195
80Purine metabolism_Homo sapiens_hsa002300.82130253
81Epstein-Barr virus infection_Homo sapiens_hsa051690.82003241
82MAPK signaling pathway_Homo sapiens_hsa040100.81191632
83Insulin secretion_Homo sapiens_hsa049110.80488817
84Melanogenesis_Homo sapiens_hsa049160.80253362
85Huntingtons disease_Homo sapiens_hsa050160.79932025
86GnRH signaling pathway_Homo sapiens_hsa049120.79550600
87Selenocompound metabolism_Homo sapiens_hsa004500.79189444
88Pyruvate metabolism_Homo sapiens_hsa006200.77558221
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77118643
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.76654037
91Folate biosynthesis_Homo sapiens_hsa007900.75794307
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.74957231
93Viral myocarditis_Homo sapiens_hsa054160.74327710
94Chemokine signaling pathway_Homo sapiens_hsa040620.73584608
95Cocaine addiction_Homo sapiens_hsa050300.73332157
96Hippo signaling pathway_Homo sapiens_hsa043900.72431692
97Alcoholism_Homo sapiens_hsa050340.71488776
98Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71044537
99RNA polymerase_Homo sapiens_hsa030200.71002692
100Alzheimers disease_Homo sapiens_hsa050100.68875287
101Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.68848484
102Dorso-ventral axis formation_Homo sapiens_hsa043200.68281975
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67729647
104Circadian rhythm_Homo sapiens_hsa047100.67679482
105Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.67499346
106Calcium signaling pathway_Homo sapiens_hsa040200.66841629
107Colorectal cancer_Homo sapiens_hsa052100.66538955
108Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66364484
109Thyroid cancer_Homo sapiens_hsa052160.65998039
110Ras signaling pathway_Homo sapiens_hsa040140.65942227
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61721450
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.60926216
113Renin secretion_Homo sapiens_hsa049240.60677481
114Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60154546
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59531905
116Carbon metabolism_Homo sapiens_hsa012000.59376133
117Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59321126
118Autoimmune thyroid disease_Homo sapiens_hsa053200.59059500
119Salivary secretion_Homo sapiens_hsa049700.59057673
120p53 signaling pathway_Homo sapiens_hsa041150.58871643
121Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.58384788
122One carbon pool by folate_Homo sapiens_hsa006700.57495388
123Prolactin signaling pathway_Homo sapiens_hsa049170.57392182
124Biosynthesis of amino acids_Homo sapiens_hsa012300.57099223
125Tuberculosis_Homo sapiens_hsa051520.56232355
126Endocytosis_Homo sapiens_hsa041440.56065212
127Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.55793746
128Wnt signaling pathway_Homo sapiens_hsa043100.55609364
129NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55431113
130Tight junction_Homo sapiens_hsa045300.55150551
131Gastric acid secretion_Homo sapiens_hsa049710.54581737
132Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53910927
133Renal cell carcinoma_Homo sapiens_hsa052110.53501149
134Estrogen signaling pathway_Homo sapiens_hsa049150.53254012
135TNF signaling pathway_Homo sapiens_hsa046680.52644203
136Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.52361121
137Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50955766
138Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50791439
139Rap1 signaling pathway_Homo sapiens_hsa040150.50540648
140cAMP signaling pathway_Homo sapiens_hsa040240.50465467
141Apoptosis_Homo sapiens_hsa042100.49666575
142Hedgehog signaling pathway_Homo sapiens_hsa043400.49341815
143Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.49180647
144Leishmaniasis_Homo sapiens_hsa051400.49151167
145Asthma_Homo sapiens_hsa053100.48317633
146Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45914640
147Legionellosis_Homo sapiens_hsa051340.45067002
148Metabolic pathways_Homo sapiens_hsa011000.44161003
149Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43659591
150Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41463065
151Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.34763369
152Ether lipid metabolism_Homo sapiens_hsa005650.31008925
153Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28549209

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