DUSP5P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of hippo signaling (GO:0035330)6.89723991
2protein maturation by protein folding (GO:0022417)6.62909028
3GMP metabolic process (GO:0046037)6.14648967
4proline metabolic process (GO:0006560)6.07419834
5piRNA metabolic process (GO:0034587)6.06708567
6glial cell proliferation (GO:0014009)5.90058590
7neural tube formation (GO:0001841)5.66336621
84-hydroxyproline metabolic process (GO:0019471)5.61534100
9purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)5.44313927
10cornea development in camera-type eye (GO:0061303)5.28778664
11lung morphogenesis (GO:0060425)5.01742614
12DNA methylation involved in gamete generation (GO:0043046)4.88981176
13limb bud formation (GO:0060174)4.84092056
14cell junction maintenance (GO:0034331)4.71044284
15proline biosynthetic process (GO:0006561)4.70524851
16cell-cell junction maintenance (GO:0045217)4.61120425
17tryptophan catabolic process (GO:0006569)4.59304356
18indole-containing compound catabolic process (GO:0042436)4.59304356
19indolalkylamine catabolic process (GO:0046218)4.59304356
20negative regulation of glial cell proliferation (GO:0060253)4.49713071
21lens morphogenesis in camera-type eye (GO:0002089)4.47265403
22eyelid development in camera-type eye (GO:0061029)4.44328393
23negative regulation of cell size (GO:0045792)4.19678655
24cardiac ventricle formation (GO:0003211)4.17979689
25nucleoside diphosphate biosynthetic process (GO:0009133)4.17611073
26clathrin coat assembly (GO:0048268)4.09284469
27negative regulation of T cell differentiation in thymus (GO:0033085)4.02574902
28snRNA transcription (GO:0009301)3.96575237
29GDP-mannose metabolic process (GO:0019673)3.95872691
30response to phenylpropanoid (GO:0080184)3.88259863
31meiotic chromosome segregation (GO:0045132)3.87414959
32positive regulation of vascular permeability (GO:0043117)3.85589403
33sympathetic nervous system development (GO:0048485)3.84290415
34regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.83669919
35negative regulation of calcium ion transport into cytosol (GO:0010523)3.83548137
36cardiac chamber formation (GO:0003207)3.77747123
37spinal cord development (GO:0021510)3.77046917
38drinking behavior (GO:0042756)3.71214650
39purine deoxyribonucleotide metabolic process (GO:0009151)3.71102519
40single strand break repair (GO:0000012)3.71075523
41substrate-independent telencephalic tangential migration (GO:0021826)3.69050524
42substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.69050524
43negative regulation of digestive system process (GO:0060457)3.63732628
44tryptophan metabolic process (GO:0006568)3.62175929
45male meiosis (GO:0007140)3.61015091
46somite development (GO:0061053)3.57360141
47Golgi transport vesicle coating (GO:0048200)3.49517567
48COPI coating of Golgi vesicle (GO:0048205)3.49517567
49negative regulation of adherens junction organization (GO:1903392)3.48209880
50negative regulation of focal adhesion assembly (GO:0051895)3.48209880
51negative regulation of cell junction assembly (GO:1901889)3.48209880
52myoblast migration (GO:0051451)3.44104860
53phagocytosis, recognition (GO:0006910)3.44025205
54cellular component maintenance (GO:0043954)3.41521488
55lung epithelium development (GO:0060428)3.37639041
56positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.34765745
57morphogenesis of an epithelial sheet (GO:0002011)3.33488023
58regulation of acyl-CoA biosynthetic process (GO:0050812)3.32778981
59negative regulation of fibrinolysis (GO:0051918)3.29675582
60purine ribonucleoside diphosphate metabolic process (GO:0009179)3.28672887
61purine nucleoside diphosphate metabolic process (GO:0009135)3.28672887
62regulation of integrin-mediated signaling pathway (GO:2001044)3.26473412
63positive regulation of collagen biosynthetic process (GO:0032967)3.22473685
64seminiferous tubule development (GO:0072520)3.17836031
65regulation of translational fidelity (GO:0006450)3.15737160
66regulation of metalloenzyme activity (GO:0048552)3.11087459
67regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.09157823
68regulation of female receptivity (GO:0045924)3.06609453
69regulation of coenzyme metabolic process (GO:0051196)3.06177593
70regulation of cofactor metabolic process (GO:0051193)3.06177593
71regulation of cholesterol homeostasis (GO:2000188)3.05805724
72positive regulation of protein targeting to membrane (GO:0090314)3.03949243
73acrosome reaction (GO:0007340)3.02067925
74positive regulation of collagen metabolic process (GO:0010714)3.00612346
75ventricular septum morphogenesis (GO:0060412)3.00179300
76deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.97105926
77regulation of cholesterol biosynthetic process (GO:0045540)2.86320323
78endothelial cell proliferation (GO:0001935)2.86099597
79aromatic amino acid family catabolic process (GO:0009074)2.86005924
80positive regulation of vesicle fusion (GO:0031340)2.81328097
81coenzyme catabolic process (GO:0009109)2.81049207
82nucleobase-containing small molecule interconversion (GO:0015949)2.80364088
83response to redox state (GO:0051775)2.78970639
84vesicle coating (GO:0006901)2.75978469
85regulation of telomere maintenance via telomerase (GO:0032210)2.74510619
86synaptic vesicle docking involved in exocytosis (GO:0016081)2.73421866
87protein carboxylation (GO:0018214)2.71283974
88peptidyl-glutamic acid carboxylation (GO:0017187)2.71283974
89protein retention in ER lumen (GO:0006621)2.69874639
90nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.69600559
91oligodendrocyte development (GO:0014003)2.66943847
92maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.66578341
93establishment of epithelial cell polarity (GO:0090162)2.65143871
94endothelial cell morphogenesis (GO:0001886)2.60877826
95snRNA metabolic process (GO:0016073)2.60832205
96fusion of sperm to egg plasma membrane (GO:0007342)2.60298058
97cytoplasmic mRNA processing body assembly (GO:0033962)2.58934883
98cholesterol efflux (GO:0033344)2.58884242
99isoprenoid biosynthetic process (GO:0008299)2.57747535
100positive regulation of bone resorption (GO:0045780)2.57401929

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.53525501
2ZNF263_19887448_ChIP-Seq_K562_Human4.81945017
3DMRT1_21621532_ChIP-ChIP_FETAL_Ovary4.29969628
4TP63_17297297_ChIP-ChIP_HaCaT_Human4.22320014
5HIF1A_21447827_ChIP-Seq_MCF-7_Human3.94963129
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.24950925
7E2F7_22180533_ChIP-Seq_HELA_Human3.18255480
8CLOCK_20551151_ChIP-Seq_293T_Human2.48763736
9TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.45155830
10ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.43300430
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.31670816
12STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.24884485
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.16216419
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.16104823
15ELK3_25401928_ChIP-Seq_HUVEC_Human1.99992831
16ESR1_15608294_ChIP-ChIP_MCF-7_Human1.99838642
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.90493275
18EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.86395982
19LXR_22292898_ChIP-Seq_THP-1_Human1.85173133
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.83554228
21RACK7_27058665_Chip-Seq_MCF-7_Human1.81873050
22ERG_21242973_ChIP-ChIP_JURKAT_Human1.80763706
23HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.75406474
24WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.71276409
25ESR1_20079471_ChIP-ChIP_T-47D_Human1.70377309
26DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.68902339
27TP53_22127205_ChIP-Seq_IMR90_Human1.67236558
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.58652774
29PPARA_22158963_ChIP-Seq_LIVER_Mouse1.58554859
30ESR1_21235772_ChIP-Seq_MCF-7_Human1.57315030
31KDM5A_27292631_Chip-Seq_BREAST_Human1.57044618
32KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.55115158
33PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.50825458
34SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.50441010
35NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.50308112
36RARB_24833708_ChIP-Seq_LIVER_Mouse1.45831540
37PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.44390159
38GABP_19822575_ChIP-Seq_HepG2_Human1.38344803
39SMC4_20622854_ChIP-Seq_HELA_Human1.38150012
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37774967
41GATA2_21666600_ChIP-Seq_HMVEC_Human1.37631464
42UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.37387859
43NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.37384164
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.33264475
45RARG_19884340_ChIP-ChIP_MEFs_Mouse1.32922592
46CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.32429073
47RXR_22158963_ChIP-Seq_LIVER_Mouse1.31026309
48ELF1_20517297_ChIP-Seq_JURKAT_Human1.27135965
49TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.26932618
50TET1_21451524_ChIP-Seq_MESCs_Mouse1.25601358
51STAT3_1855785_ChIP-Seq_MESCs_Mouse1.24599820
52ZFP281_18757296_ChIP-ChIP_E14_Mouse1.23740615
53KDM2B_26808549_Chip-Seq_K562_Human1.23414327
54PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.22308018
55KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.22210627
56HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.21049782
57ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.20448555
58KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20431394
59ESR2_21235772_ChIP-Seq_MCF-7_Human1.18340799
60ATF3_27146783_Chip-Seq_COLON_Human1.15099885
61P68_20966046_ChIP-Seq_HELA_Human1.14779617
62TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.13781253
63AR_21909140_ChIP-Seq_LNCAP_Human1.13605167
64YY1_21170310_ChIP-Seq_MESCs_Mouse1.13365215
65SOX2_18555785_ChIP-Seq_MESCs_Mouse1.12285587
66ELF1_17652178_ChIP-ChIP_JURKAT_Human1.11537411
67EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.11032185
68CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10183148
69CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09973246
70SALL1_21062744_ChIP-ChIP_HESCs_Human1.09197752
71ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.08310044
72NELFA_20434984_ChIP-Seq_ESCs_Mouse1.08050229
73RUNX1_27514584_Chip-Seq_MCF-7_Human1.06313759
74NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.05950634
75FOXA2_19822575_ChIP-Seq_HepG2_Human1.05762940
76ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05539144
77UBF1/2_26484160_Chip-Seq_HMECs_Human1.04793629
78TET1_21490601_ChIP-Seq_MESCs_Mouse1.04495012
79SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03748959
80RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.03623423
81KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00788979
82SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.98798797
83TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95558782
84SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.95460593
85TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.95396272
86BCL6_27268052_Chip-Seq_Bcells_Human0.94872959
87LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.94742816
88SPI1_26923725_Chip-Seq_HPCs_Mouse0.94020724
89PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.93889470
90XRN2_22483619_ChIP-Seq_HELA_Human0.93055774
91KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92855404
92BCOR_27268052_Chip-Seq_Bcells_Human0.92008066
93KDM2B_26808549_Chip-Seq_DND41_Human0.91736538
94GATA1_22383799_ChIP-Seq_G1ME_Mouse0.91714343
95JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.91706550
96POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.89404986
97GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.87700948
98MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.87000882
99NFIB_24661679_ChIP-Seq_LUNG_Mouse0.86778125
100RARA_24833708_ChIP-Seq_LIVER_Mouse0.86755852

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition5.07235868
2MP0004147_increased_porphyrin_level5.05910683
3MP0006054_spinal_hemorrhage4.34491095
4MP0002089_abnormal_postnatal_growth/wei3.58754647
5MP0008057_abnormal_DNA_replication3.51749870
6MP0003705_abnormal_hypodermis_morpholog2.53067443
7MP0003122_maternal_imprinting2.45426858
8MP0004272_abnormal_basement_membrane2.44130706
9MP0005360_urolithiasis2.44065714
10MP0008875_abnormal_xenobiotic_pharmacok2.38980319
11MP0003115_abnormal_respiratory_system2.36665245
12MP0005409_darkened_coat_color2.36644630
13MP0000003_abnormal_adipose_tissue2.27886043
14MP0003191_abnormal_cellular_cholesterol2.26437088
15MP0004134_abnormal_chest_morphology2.13044797
16MP0001661_extended_life_span1.96268811
17MP0008438_abnormal_cutaneous_collagen1.94416381
18MP0003385_abnormal_body_wall1.93617542
19MP0002751_abnormal_autonomic_nervous1.86300250
20MP0000013_abnormal_adipose_tissue1.84072996
21MP0003123_paternal_imprinting1.66740144
22MP0005375_adipose_tissue_phenotype1.55510401
23MP0004782_abnormal_surfactant_physiolog1.51076421
24MP0010352_gastrointestinal_tract_polyps1.47918727
25MP0006035_abnormal_mitochondrial_morpho1.45638011
26MP0008058_abnormal_DNA_repair1.44966700
27MP0003943_abnormal_hepatobiliary_system1.42049609
28MP0000639_abnormal_adrenal_gland1.40566522
29MP0002184_abnormal_innervation1.37845058
30MP0000358_abnormal_cell_content/1.37569284
31MP0005076_abnormal_cell_differentiation1.35054356
32MP0001270_distended_abdomen1.33930471
33MP0005365_abnormal_bile_salt1.32592660
34MP0004233_abnormal_muscle_weight1.30863213
35MP0003937_abnormal_limbs/digits/tail_de1.27597910
36MP0009672_abnormal_birth_weight1.26863660
37MP0009250_abnormal_appendicular_skeleto1.24385551
38MP0002938_white_spotting1.23646728
39MP0004858_abnormal_nervous_system1.20458899
40MP0005408_hypopigmentation1.18145145
41MP0002697_abnormal_eye_size1.17755429
42MP0005257_abnormal_intraocular_pressure1.17109725
43MP0000467_abnormal_esophagus_morphology1.16821855
44MP0009840_abnormal_foam_cell1.15728156
45MP0001849_ear_inflammation1.14566740
46MP0003566_abnormal_cell_adhesion1.14315963
47MP0005666_abnormal_adipose_tissue1.14244590
48MP0010368_abnormal_lymphatic_system1.14213471
49MP0010329_abnormal_lipoprotein_level1.09082143
50MP0000537_abnormal_urethra_morphology1.06537186
51MP0001299_abnormal_eye_distance/1.06310913
52MP0003935_abnormal_craniofacial_develop1.05191206
53MP0000566_synostosis1.03212024
54MP0003942_abnormal_urinary_system1.02236912
55MP0005266_abnormal_metabolism0.99832372
56MP0002970_abnormal_white_adipose0.98465250
57MP0002332_abnormal_exercise_endurance0.97289725
58MP0002116_abnormal_craniofacial_bone0.95610012
59MP0006138_congestive_heart_failure0.94015363
60MP0004185_abnormal_adipocyte_glucose0.93897455
61MP0000462_abnormal_digestive_system0.93635354
62MP0000678_abnormal_parathyroid_gland0.92837704
63MP0000647_abnormal_sebaceous_gland0.92730982
64MP0000858_altered_metastatic_potential0.92018415
65MP0002282_abnormal_trachea_morphology0.90478258
66MP0002249_abnormal_larynx_morphology0.88758278
67MP0003879_abnormal_hair_cell0.88242245
68MP0003329_amyloid_beta_deposits0.87833297
69MP0003868_abnormal_feces_composition0.87260555
70MP0004084_abnormal_cardiac_muscle0.85774338
71MP0002653_abnormal_ependyma_morphology0.84843621
72MP0003303_peritoneal_inflammation0.84522806
73MP0004197_abnormal_fetal_growth/weight/0.84243195
74MP0002971_abnormal_brown_adipose0.83479293
75MP0003755_abnormal_palate_morphology0.81326369
76MP0003948_abnormal_gas_homeostasis0.80042675
77MP0005330_cardiomyopathy0.78861550
78MP0002111_abnormal_tail_morphology0.78246335
79MP0005501_abnormal_skin_physiology0.75358822
80MP0001915_intracranial_hemorrhage0.74762162
81MP0005623_abnormal_meninges_morphology0.74448745
82MP0002113_abnormal_skeleton_development0.73892172
83MP0008775_abnormal_heart_ventricle0.73748326
84MP0005410_abnormal_fertilization0.68305460
85MP0010630_abnormal_cardiac_muscle0.68023296
86MP0002115_abnormal_skeleton_extremities0.68018251
87MP0000767_abnormal_smooth_muscle0.67029778
88MP0002080_prenatal_lethality0.66432163
89MP0003632_abnormal_nervous_system0.66327022
90MP0001879_abnormal_lymphatic_vessel0.65390399
91MP0000681_abnormal_thyroid_gland0.65185372
92MP0005332_abnormal_amino_acid0.65138060
93MP0004130_abnormal_muscle_cell0.64711168
94MP0002086_abnormal_extraembryonic_tissu0.63456035
95MP0000534_abnormal_ureter_morphology0.63440048
96MP0005384_cellular_phenotype0.63110543
97MP0000432_abnormal_head_morphology0.63099295
98MP0001340_abnormal_eyelid_morphology0.62810744
99MP0001243_abnormal_dermal_layer0.62381535
100MP0003698_abnormal_male_reproductive0.62040983

Predicted human phenotypes

RankGene SetZ-score
1Zonular cataract (HP:0010920)5.54734951
2Decreased number of large peripheral myelinated nerve fibers (HP:0003387)5.29778805
3Insidious onset (HP:0003587)5.27846278
4Termporal pattern (HP:0011008)5.27846278
5Ulnar claw (HP:0001178)4.97573776
6Upper limb muscle weakness (HP:0003484)4.49891293
7Deep venous thrombosis (HP:0002625)4.24253944
8Abnormal pupillary function (HP:0007686)4.02700107
9Segmental peripheral demyelination/remyelination (HP:0003481)3.82164522
10Decreased number of peripheral myelinated nerve fibers (HP:0003380)3.70183207
11Peripheral hypomyelination (HP:0007182)3.65335200
12Action tremor (HP:0002345)3.64809907
13Progressive hearing impairment (HP:0001730)3.49486083
14Hydroxyprolinuria (HP:0003080)3.48922406
15Abnormality of proline metabolism (HP:0010907)3.48922406
16Progressive sensorineural hearing impairment (HP:0000408)3.08410145
17Impaired proprioception (HP:0010831)3.01916635
18Gastrointestinal infarctions (HP:0005244)2.90508863
19Choreoathetosis (HP:0001266)2.85240755
20Poor speech (HP:0002465)2.85024741
21Abnormality of the intervertebral disk (HP:0005108)2.82442564
22Lissencephaly (HP:0001339)2.81682343
23Protrusio acetabuli (HP:0003179)2.81368786
24Hypercholesterolemia (HP:0003124)2.75718766
25Progressive external ophthalmoplegia (HP:0000590)2.73564131
26Premature rupture of membranes (HP:0001788)2.73034861
27Flat acetabular roof (HP:0003180)2.60272272
28Stridor (HP:0010307)2.59338546
29Ragged-red muscle fibers (HP:0003200)2.57973787
30Postural tremor (HP:0002174)2.55749737
31Nuclear cataract (HP:0100018)2.54508254
32Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.54315435
33Abnormality of homocysteine metabolism (HP:0010919)2.49687455
34Homocystinuria (HP:0002156)2.49687455
35Abnormality of glutamine family amino acid metabolism (HP:0010902)2.42755270
36Brushfield spots (HP:0001088)2.40892671
37Broad alveolar ridges (HP:0000187)2.40802883
38Abnormality of the astrocytes (HP:0100707)2.40227046
39Astrocytoma (HP:0009592)2.40227046
40Hammertoe (HP:0001765)2.35162840
41Delayed gross motor development (HP:0002194)2.30612532
42Abnormal mitochondria in muscle tissue (HP:0008316)2.26979088
43Limb dystonia (HP:0002451)2.24991762
44Ependymoma (HP:0002888)2.20377481
45Drooling (HP:0002307)2.19615284
46Spinal cord compression (HP:0002176)2.17126664
47Heterotopia (HP:0002282)2.17084900
48Conjugated hyperbilirubinemia (HP:0002908)2.16911434
49Abnormality of lateral ventricle (HP:0030047)2.04933130
50Febrile seizures (HP:0002373)2.04647891
51Overlapping toe (HP:0001845)2.04013736
52Athetosis (HP:0002305)2.02898978
53Steppage gait (HP:0003376)2.01995663
54Distal sensory impairment (HP:0002936)1.99191037
55Thin bony cortex (HP:0002753)1.96781898
56Osteomalacia (HP:0002749)1.96205802
57Excessive salivation (HP:0003781)1.96185650
58Abnormality of the alveolar ridges (HP:0006477)1.94358200
59Ulnar bowing (HP:0003031)1.93877607
60Upper limb amyotrophy (HP:0009129)1.93770136
61Distal upper limb amyotrophy (HP:0007149)1.93770136
62Ankle clonus (HP:0011448)1.92321465
63Patellar aplasia (HP:0006443)1.91730071
64Epidermoid cyst (HP:0200040)1.91009497
65Foot dorsiflexor weakness (HP:0009027)1.90363244
66Facial hemangioma (HP:0000329)1.89647672
67Hypophosphatemic rickets (HP:0004912)1.88788624
68Absent hand (HP:0004050)1.88136539
69Poikiloderma (HP:0001029)1.88018802
70Neonatal death (HP:0003811)1.88017829
71Glomerulonephritis (HP:0000099)1.87636614
72Hyperacusis (HP:0010780)1.87089146
73Onion bulb formation (HP:0003383)1.85228805
74Adrenal hypoplasia (HP:0000835)1.82306887
75Aplasia involving bones of the extremities (HP:0009825)1.82276716
76Aplasia involving bones of the upper limbs (HP:0009823)1.82276716
77Aplasia of the phalanges of the hand (HP:0009802)1.82276716
78Vertebral compression fractures (HP:0002953)1.82142529
79Cerebral aneurysm (HP:0004944)1.81929102
80Aplasia/Hypoplasia of the patella (HP:0006498)1.81647827
81Hand muscle atrophy (HP:0009130)1.80670192
82Menorrhagia (HP:0000132)1.79552684
83Protruding ear (HP:0000411)1.79531523
84Wide intermamillary distance (HP:0006610)1.77806354
85Self-mutilation (HP:0000742)1.75506996
86Abnormality of carpal bone ossification (HP:0006257)1.74267685
87Short tibia (HP:0005736)1.73419578
88Abnormality of dentin (HP:0010299)1.73001186
89Aneurysm (HP:0002617)1.71766225
90Rectal prolapse (HP:0002035)1.71468131
91Mucopolysacchariduria (HP:0008155)1.68522487
92Urinary glycosaminoglycan excretion (HP:0003541)1.68522487
93Abnormality of polysaccharide metabolism (HP:0011012)1.68411050
94Abnormality of glycosaminoglycan metabolism (HP:0004371)1.68411050
95Abnormality of mucopolysaccharide metabolism (HP:0011020)1.68411050
96Aortic regurgitation (HP:0001659)1.68346037
97Broad face (HP:0000283)1.66866259
98Entropion (HP:0000621)1.64720742
99Posterior embryotoxon (HP:0000627)1.63394215
100Renal duplication (HP:0000075)1.63202029

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK26.60985582
2ICK4.75130833
3NEK23.91681683
4TRIB33.73300020
5TAOK33.58770653
6MST1R3.26236709
7EPHA42.72903891
8EEF2K2.67808242
9FGFR42.64088624
10PKN22.47987044
11TESK12.20715903
12MINK11.95606562
13MET1.95164098
14IRAK31.77277790
15PTK21.64465709
16MAP3K131.61364603
17SIK11.59805949
18EPHA21.47375514
19NTRK31.34422014
20LIMK11.33119027
21PRKCI1.28711466
22FLT31.21501923
23MATK1.16605826
24CDK71.14669243
25RPS6KB21.13801090
26PDGFRA1.12268298
27RPS6KA51.09184353
28RPS6KA41.04753200
29RIPK11.02902317
30NME21.02474026
31CDK120.91701528
32BRSK10.85037788
33ERN10.84372880
34LATS20.83911659
35MAP3K140.83557710
36TGFBR20.82221672
37PIM20.79878673
38MTOR0.79873800
39RPS6KA20.74259264
40DAPK20.73895562
41PAK40.71847588
42PRKAA20.69973979
43CAMKK10.69526395
44KIT0.69104529
45CDK80.67729921
46MAP2K60.66837742
47ERBB40.66560300
48TTN0.64542897
49NTRK10.62237334
50CHEK10.60240440
51MAPK80.57063882
52BRSK20.56411513
53FGFR30.55755813
54CAMK2A0.52160519
55CHUK0.52022881
56MOS0.51941466
57CDC42BPA0.48597345
58MAPK110.48449760
59STK390.48191747
60CDK140.48074270
61BMX0.47306356
62PDK20.46927231
63EIF2AK30.45799430
64MAP3K70.45294722
65MAPK100.45217325
66MAPKAPK30.44842921
67PRKCG0.44716949
68CDK150.44299165
69TYRO30.44217256
70RPS6KC10.42667288
71RPS6KL10.42667288
72RPS6KB10.42498184
73SRPK10.42293253
74LMTK20.41803520
75CDK10.41530717
76RPS6KA10.40367442
77CDK180.40283604
78ILK0.40250936
79FGFR10.39930035
80CDK40.39724123
81PTK60.39216584
82RPS6KA60.36945432
83MAPK10.35516378
84CDK11A0.34996598
85EIF2AK10.34730377
86ARAF0.33907361
87TESK20.32823613
88MARK20.32339869
89CSNK1A10.32084710
90MKNK20.31721484
91RAF10.31682685
92CAMK2B0.31069855
93MELK0.30327647
94DDR20.30279782
95CAMK2D0.30229071
96RET0.29307798
97PRKAA10.28951675
98PRKG20.27275972
99GSK3B0.27239935
100CSNK2A20.26083724

Predicted pathways (KEGG)

RankGene SetZ-score
1ABC transporters_Homo sapiens_hsa020103.80247393
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.25434364
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.62487813
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.49231604
5Complement and coagulation cascades_Homo sapiens_hsa046102.35845481
6Pyruvate metabolism_Homo sapiens_hsa006202.29875910
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.13585995
8Glycosaminoglycan degradation_Homo sapiens_hsa005312.07067924
9Other glycan degradation_Homo sapiens_hsa005112.06539008
10Fatty acid biosynthesis_Homo sapiens_hsa000612.02311131
11Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.00612716
12N-Glycan biosynthesis_Homo sapiens_hsa005101.80238720
13Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.79617129
14ECM-receptor interaction_Homo sapiens_hsa045121.76086597
15Vibrio cholerae infection_Homo sapiens_hsa051101.73514994
16Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.62616942
17Arginine and proline metabolism_Homo sapiens_hsa003301.60257669
18Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.59194338
19Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.56460520
20Non-homologous end-joining_Homo sapiens_hsa034501.55930076
21Cyanoamino acid metabolism_Homo sapiens_hsa004601.54763772
22Fatty acid metabolism_Homo sapiens_hsa012121.45894796
23Histidine metabolism_Homo sapiens_hsa003401.32127560
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.30947899
25Phenylalanine metabolism_Homo sapiens_hsa003601.22608763
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.21004767
27Tyrosine metabolism_Homo sapiens_hsa003501.19811921
28Fructose and mannose metabolism_Homo sapiens_hsa000511.16535518
29mTOR signaling pathway_Homo sapiens_hsa041501.11238488
30Bladder cancer_Homo sapiens_hsa052191.09519131
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01891598
32Biosynthesis of amino acids_Homo sapiens_hsa012301.01305591
33Purine metabolism_Homo sapiens_hsa002301.01274461
34Focal adhesion_Homo sapiens_hsa045101.00746328
35Small cell lung cancer_Homo sapiens_hsa052220.96408897
36Shigellosis_Homo sapiens_hsa051310.93876554
37PPAR signaling pathway_Homo sapiens_hsa033200.93838680
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89451085
39Central carbon metabolism in cancer_Homo sapiens_hsa052300.89360663
40Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.85842239
41Pancreatic cancer_Homo sapiens_hsa052120.84457652
42Fat digestion and absorption_Homo sapiens_hsa049750.83365865
43Hippo signaling pathway_Homo sapiens_hsa043900.83079951
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.82506157
45Bile secretion_Homo sapiens_hsa049760.81812908
46Base excision repair_Homo sapiens_hsa034100.81290749
47Vitamin digestion and absorption_Homo sapiens_hsa049770.80244607
48Peroxisome_Homo sapiens_hsa041460.78347314
49Fatty acid elongation_Homo sapiens_hsa000620.75212045
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74493797
51Carbon metabolism_Homo sapiens_hsa012000.73947963
52Adherens junction_Homo sapiens_hsa045200.71567981
53Galactose metabolism_Homo sapiens_hsa000520.70902027
54AMPK signaling pathway_Homo sapiens_hsa041520.70807149
55Chronic myeloid leukemia_Homo sapiens_hsa052200.69833169
56Arginine biosynthesis_Homo sapiens_hsa002200.69494893
57HIF-1 signaling pathway_Homo sapiens_hsa040660.69336885
58Thyroid hormone synthesis_Homo sapiens_hsa049180.68207227
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.67871452
60Insulin resistance_Homo sapiens_hsa049310.66074397
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.65691793
62PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64826298
63Protein digestion and absorption_Homo sapiens_hsa049740.64159039
64DNA replication_Homo sapiens_hsa030300.63224166
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.61267672
66Pentose phosphate pathway_Homo sapiens_hsa000300.58072664
67Oocyte meiosis_Homo sapiens_hsa041140.55160536
68Steroid biosynthesis_Homo sapiens_hsa001000.54591758
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.53941678
70Cell cycle_Homo sapiens_hsa041100.53619632
71Legionellosis_Homo sapiens_hsa051340.53445589
72Lysosome_Homo sapiens_hsa041420.53034881
73Vitamin B6 metabolism_Homo sapiens_hsa007500.52921925
74Cocaine addiction_Homo sapiens_hsa050300.52165551
75Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49936303
76VEGF signaling pathway_Homo sapiens_hsa043700.49692394
77Insulin signaling pathway_Homo sapiens_hsa049100.48894601
78Non-small cell lung cancer_Homo sapiens_hsa052230.48423562
79Estrogen signaling pathway_Homo sapiens_hsa049150.47510138
80Endocytosis_Homo sapiens_hsa041440.47317531
81Glutamatergic synapse_Homo sapiens_hsa047240.46594267
82GABAergic synapse_Homo sapiens_hsa047270.45733709
83Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45295301
84Proteoglycans in cancer_Homo sapiens_hsa052050.45095704
85One carbon pool by folate_Homo sapiens_hsa006700.44864773
86ErbB signaling pathway_Homo sapiens_hsa040120.44548946
87Ovarian steroidogenesis_Homo sapiens_hsa049130.44442390
88GnRH signaling pathway_Homo sapiens_hsa049120.40365217
89Aldosterone synthesis and secretion_Homo sapiens_hsa049250.39100176
90Amoebiasis_Homo sapiens_hsa051460.37579550
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.37409545
92Salmonella infection_Homo sapiens_hsa051320.37292710
93Dilated cardiomyopathy_Homo sapiens_hsa054140.35302351
94Salivary secretion_Homo sapiens_hsa049700.34904238
95Dopaminergic synapse_Homo sapiens_hsa047280.34734179
96Alcoholism_Homo sapiens_hsa050340.34627817
97Axon guidance_Homo sapiens_hsa043600.33956170
98Morphine addiction_Homo sapiens_hsa050320.33901009
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33707909
100RNA transport_Homo sapiens_hsa030130.33259534

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