DUSP22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)6.35360180
2positive regulation of gamma-delta T cell activation (GO:0046645)5.72145766
3negative regulation of cell killing (GO:0031342)5.46931626
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.46931626
5regulation of B cell receptor signaling pathway (GO:0050855)4.79526881
6antigen processing and presentation of endogenous antigen (GO:0019883)4.78448256
7regulation of phospholipase A2 activity (GO:0032429)4.53762472
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.51950345
9B cell receptor signaling pathway (GO:0050853)4.39271955
10establishment of skin barrier (GO:0061436)4.32259816
11immunoglobulin mediated immune response (GO:0016064)4.22441249
12sphingoid metabolic process (GO:0046519)4.09320312
13positive regulation of B cell differentiation (GO:0045579)4.04889677
14antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.04153564
15regulation of gamma-delta T cell activation (GO:0046643)3.99455486
16positive regulation of antigen processing and presentation (GO:0002579)3.97776271
17regulation of water loss via skin (GO:0033561)3.95334748
18glucosamine-containing compound catabolic process (GO:1901072)3.90193213
19response to peptidoglycan (GO:0032494)3.88927836
20keratinization (GO:0031424)3.83865563
21negative regulation of erythrocyte differentiation (GO:0045647)3.82749702
22regulation of dendritic cell antigen processing and presentation (GO:0002604)3.82534855
23positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.82463825
24positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.81394806
25sphingosine metabolic process (GO:0006670)3.67343628
26negative regulation of interleukin-12 production (GO:0032695)3.67195669
27regulation of mast cell degranulation (GO:0043304)3.59139124
28interferon-gamma-mediated signaling pathway (GO:0060333)3.56018260
29defense response to protozoan (GO:0042832)3.56005905
30T cell migration (GO:0072678)3.53192534
31positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.52399274
32positive regulation of mast cell activation (GO:0033005)3.50908302
33response to muramyl dipeptide (GO:0032495)3.40271324
34positive regulation of monocyte chemotaxis (GO:0090026)3.40090575
35B cell mediated immunity (GO:0019724)3.39765483
36positive thymic T cell selection (GO:0045059)3.39709513
37regulation of alpha-beta T cell proliferation (GO:0046640)3.37340203
38regulation of gamma-delta T cell differentiation (GO:0045586)3.35034620
39regulation of B cell differentiation (GO:0045577)3.34977585
40type I interferon signaling pathway (GO:0060337)3.34905250
41cellular response to type I interferon (GO:0071357)3.34905250
42response to type I interferon (GO:0034340)3.34701336
43positive regulation of vesicle fusion (GO:0031340)3.33943347
44regulation of antigen processing and presentation (GO:0002577)3.33685285
45response to host immune response (GO:0052572)3.32980314
46response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.32980314
47negative regulation of lymphocyte mediated immunity (GO:0002707)3.32836617
48diol metabolic process (GO:0034311)3.32162495
49myeloid cell activation involved in immune response (GO:0002275)3.29777608
50germinal center formation (GO:0002467)3.28503124
51negative thymic T cell selection (GO:0045060)3.27168361
52keratinocyte proliferation (GO:0043616)3.26978290
53regulation of mast cell activation involved in immune response (GO:0033006)3.26626314
54response to protozoan (GO:0001562)3.22607494
55negative regulation of leukocyte mediated immunity (GO:0002704)3.21150042
56regulation of interferon-beta biosynthetic process (GO:0045357)3.20237490
57cellular extravasation (GO:0045123)3.19811116
58neutrophil activation (GO:0042119)3.17205584
59regulation of myeloid leukocyte mediated immunity (GO:0002886)3.16220553
60regulation of T-helper 1 cell differentiation (GO:0045625)3.15417007
61regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.13244999
62negative regulation of T cell mediated immunity (GO:0002710)3.10641503
63fatty acid elongation (GO:0030497)3.09348055
64detection of molecule of bacterial origin (GO:0032490)3.09047197
65negative T cell selection (GO:0043383)3.08819958
66detection of biotic stimulus (GO:0009595)3.07657088
67hemidesmosome assembly (GO:0031581)3.07574342
68regulation of leukocyte degranulation (GO:0043300)3.07265343
69B cell homeostasis (GO:0001782)3.07071309
70response to host (GO:0075136)3.06253508
71response to host defenses (GO:0052200)3.06253508
72response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.06253508
73negative regulation of innate immune response (GO:0045824)3.06063996
74granulocyte activation (GO:0036230)3.03982448
75leukocyte aggregation (GO:0070486)3.02967335
76keratinocyte differentiation (GO:0030216)3.02755994
77response to interleukin-15 (GO:0070672)3.02102717
78regulation of hypersensitivity (GO:0002883)3.01634175
79regulation of mast cell activation (GO:0033003)3.00971674
80positive regulation of type 2 immune response (GO:0002830)3.00099528
81positive regulation of B cell mediated immunity (GO:0002714)2.97936301
82positive regulation of immunoglobulin mediated immune response (GO:0002891)2.97936301
83CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.95798262
84positive regulation of interleukin-10 production (GO:0032733)2.93703569
85regulation of natural killer cell mediated immunity (GO:0002715)2.90668459
86regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.90668459
87positive regulation of mast cell activation involved in immune response (GO:0033008)2.88268378
88positive regulation of mast cell degranulation (GO:0043306)2.88268378
89cytidine deamination (GO:0009972)2.87491695
90cytidine metabolic process (GO:0046087)2.87491695
91cytidine catabolic process (GO:0006216)2.87491695
92myeloid dendritic cell activation (GO:0001773)2.87253566
93intermediate filament organization (GO:0045109)2.85162711
94T-helper 1 type immune response (GO:0042088)2.83213745
95myeloid dendritic cell differentiation (GO:0043011)2.82370436
96mast cell activation (GO:0045576)2.81656033
97regulation of tolerance induction (GO:0002643)2.81136208
98multicellular organismal water homeostasis (GO:0050891)2.80755558
99leukocyte degranulation (GO:0043299)2.80466052
100positive regulation of B cell activation (GO:0050871)2.80091506
101tolerance induction (GO:0002507)2.80077023
102neutrophil activation involved in immune response (GO:0002283)2.78974740
103T cell selection (GO:0045058)2.78641265
104positive regulation of isotype switching (GO:0045830)2.77643462
105antigen processing and presentation via MHC class Ib (GO:0002475)2.76981551
106eosinophil chemotaxis (GO:0048245)2.75102497
107positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.74666786
108lipopolysaccharide-mediated signaling pathway (GO:0031663)2.74485633
109detection of bacterium (GO:0016045)2.73274362
110phospholipid efflux (GO:0033700)2.73127689
111water homeostasis (GO:0030104)2.67151192
112regulation of interleukin-8 secretion (GO:2000482)2.67130925
113cellular response to interferon-alpha (GO:0035457)2.66258966
114regulation of chemokine secretion (GO:0090196)2.65609412
115regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.65295888
116primary alcohol catabolic process (GO:0034310)2.64608006
117eosinophil migration (GO:0072677)2.61952320
118bundle of His cell to Purkinje myocyte communication (GO:0086069)2.61677699
119positive regulation of chemokine secretion (GO:0090197)2.60503580
120detection of other organism (GO:0098543)2.59139721
121regulation of monocyte chemotaxis (GO:0090025)2.59012486
122response to phenylpropanoid (GO:0080184)2.56299412
123positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.52120037
124long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.49197898
125regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.48370972
126hydrogen peroxide biosynthetic process (GO:0050665)2.47220585
127long-chain fatty acid biosynthetic process (GO:0042759)2.45096465
128negative regulation of acute inflammatory response (GO:0002674)2.44403563
129positive regulation of T-helper 1 type immune response (GO:0002827)2.43892923
130peptide cross-linking (GO:0018149)2.43085204
131regulation of natural killer cell differentiation (GO:0032823)2.42531939
132regulation of ruffle assembly (GO:1900027)2.40767782
133mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.40156493
134cellular copper ion homeostasis (GO:0006878)2.37916963
135fatty-acyl-CoA metabolic process (GO:0035337)2.36014166
136respiratory burst (GO:0045730)2.34583451
137alkaloid metabolic process (GO:0009820)2.34583019
138positive regulation of cAMP-mediated signaling (GO:0043950)2.33930857
139regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.33264467
140microglial cell activation (GO:0001774)2.32846909
141positive regulation of glomerulus development (GO:0090193)2.32172200
142prostanoid biosynthetic process (GO:0046457)2.30568766
143prostaglandin biosynthetic process (GO:0001516)2.30568766
144positive regulation of Cdc42 GTPase activity (GO:0043089)2.30545980
145interferon-gamma secretion (GO:0072643)2.29690559
146sympathetic nervous system development (GO:0048485)2.28713068
147prostanoid metabolic process (GO:0006692)2.27654907
148prostaglandin metabolic process (GO:0006693)2.27654907
149phagosome maturation (GO:0090382)2.27550024
150detection of external biotic stimulus (GO:0098581)2.24892362
151energy coupled proton transport, down electrochemical gradient (GO:0015985)2.21312861
152ATP synthesis coupled proton transport (GO:0015986)2.21312861
153lipoxygenase pathway (GO:0019372)2.20935518
154positive regulation of interleukin-1 beta secretion (GO:0050718)2.20123907
155modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.20111150
156positive regulation by organism of defense response of other organism involved in symbiotic interact2.20111150
157modulation by symbiont of host immune response (GO:0052553)2.20111150
158positive regulation by symbiont of host defense response (GO:0052509)2.20111150
159modulation by symbiont of host defense response (GO:0052031)2.20111150
160modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.20111150
161monocyte chemotaxis (GO:0002548)2.19121721
162G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.18061958
163membrane budding (GO:0006900)2.17866392
164fibrinolysis (GO:0042730)2.17699363
165regulation of cholesterol esterification (GO:0010872)2.16729760
166positive regulation of interleukin-1 beta production (GO:0032731)2.16364157
167positive regulation of cholesterol efflux (GO:0010875)2.15934141
168CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.15253408
169T-helper cell differentiation (GO:0042093)2.15253408
170pyrimidine ribonucleoside catabolic process (GO:0046133)2.13580145
171regulation of interleukin-1 beta secretion (GO:0050706)2.13460819
172macrophage activation involved in immune response (GO:0002281)2.12457628
173erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.12183670
174L-phenylalanine catabolic process (GO:0006559)2.12183670
175negative regulation of lipase activity (GO:0060192)2.11544885
176antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.11522116
177mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.11151291
178carnitine metabolic process (GO:0009437)2.10910363
179ethanol metabolic process (GO:0006067)2.10872977
180positive regulation of cholesterol transport (GO:0032376)2.10644341
181positive regulation of sterol transport (GO:0032373)2.10644341
182epidermal cell differentiation (GO:0009913)2.10609454

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.30874916
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.39880563
3MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.38665971
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.05019025
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.02896784
6VDR_21846776_ChIP-Seq_THP-1_Human2.88669096
7MYC_22102868_ChIP-Seq_BL_Human2.87552132
8SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.65940308
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.64172720
10SCL_19346495_ChIP-Seq_HPC-7_Human2.63116446
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.60434198
12VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.51205120
13RUNX_20019798_ChIP-Seq_JUKART_Human2.49177708
14VDR_24763502_ChIP-Seq_THP-1_Human2.48387204
15* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.47038334
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.46184777
17MAF_26560356_Chip-Seq_TH1_Human2.32980284
18SPI1_23547873_ChIP-Seq_NB4_Human2.28871778
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.27855663
20SPI1_23127762_ChIP-Seq_K562_Human2.24122365
21* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.22584478
22MYB_26560356_Chip-Seq_TH2_Human2.21291664
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.20023841
24RUNX1_22412390_ChIP-Seq_EML_Mouse2.18548707
25ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.15553183
26* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.14055300
27EGR1_19374776_ChIP-ChIP_THP-1_Human2.12936905
28UTX_26944678_Chip-Seq_JUKART_Human2.11532020
29BRD4_27068464_Chip-Seq_AML-cells_Mouse2.06153997
30TCF7_22412390_ChIP-Seq_EML_Mouse2.02205958
31KDM2B_26808549_Chip-Seq_SUP-B15_Human2.01647971
32MYB_26560356_Chip-Seq_TH1_Human1.89037949
33VDR_22108803_ChIP-Seq_LS180_Human1.88425342
34MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.88295397
35NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.84830573
36P63_26484246_Chip-Seq_KERATINOCYTES_Human1.83797098
37GATA1_19941827_ChIP-Seq_MEL_Mouse1.82063266
38MAF_26560356_Chip-Seq_TH2_Human1.81049303
39Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.77575425
40CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.76446893
41BP1_19119308_ChIP-ChIP_Hs578T_Human1.75899129
42IRF8_21731497_ChIP-ChIP_J774_Mouse1.75781263
43TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.75353792
44FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.73887325
45KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.73526483
46LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.72729713
47LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.72683666
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.71389554
49TRIM28_21343339_ChIP-Seq_HEK293_Human1.64383093
50* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.59767086
51KDM2B_26808549_Chip-Seq_DND41_Human1.59339570
52RXR_22158963_ChIP-Seq_LIVER_Mouse1.58823236
53STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.57557613
54FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.57356611
55KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.56373851
56LXR_22292898_ChIP-Seq_THP-1_Human1.55334360
57GATA1_22383799_ChIP-Seq_G1ME_Mouse1.55173686
58GATA2_22383799_ChIP-Seq_G1ME_Mouse1.52023536
59ESR1_21235772_ChIP-Seq_MCF-7_Human1.50157340
60IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.49870697
61LXR_22158963_ChIP-Seq_LIVER_Mouse1.47958679
62PPARA_22158963_ChIP-Seq_LIVER_Mouse1.47180169
63SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.46876722
64* GATA3_27048872_Chip-Seq_THYMUS_Human1.46072893
65SOX2_20726797_ChIP-Seq_SW620_Human1.45540069
66CJUN_26792858_Chip-Seq_BT549_Human1.43869781
67SOX9_24532713_ChIP-Seq_HFSC_Mouse1.42563663
68* IRF8_27001747_Chip-Seq_BMDM_Mouse1.41030685
69TP53_18474530_ChIP-ChIP_U2OS_Human1.39606330
70PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.39309284
71ELK3_25401928_ChIP-Seq_HUVEC_Human1.39279661
72PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.39156147
73GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.36815066
74PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36149600
75NRF2_20460467_ChIP-Seq_MEFs_Mouse1.35037754
76NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.35037754
77CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35004772
78* BCAT_22108803_ChIP-Seq_LS180_Human1.33459014
79PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32046983
80FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.31279731
81GATA1_19941826_ChIP-Seq_K562_Human1.30722057
82SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.30548433
83TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29924693
84PU.1_20513432_ChIP-Seq_Bcells_Mouse1.28550379
85EGR1_23403033_ChIP-Seq_LIVER_Mouse1.27932258
86AR_21572438_ChIP-Seq_LNCaP_Human1.27790148
87PIAS1_25552417_ChIP-Seq_VCAP_Human1.27726649
88ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24996514
89SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.24263458
90* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23881967
91GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23645575
92ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.23116126
93* BCL6_27268052_Chip-Seq_Bcells_Human1.21475772
94CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20630965
95* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.20124819
96PU_27001747_Chip-Seq_BMDM_Mouse1.19748769
97CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18515069
98ZFP57_27257070_Chip-Seq_ESCs_Mouse1.18508896
99CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16964612
100TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.16682285
101* TP63_23658742_ChIP-Seq_EP156T_Human1.16384421
102* BCOR_27268052_Chip-Seq_Bcells_Human1.14555793
103FOXO3_23340844_ChIP-Seq_DLD1_Human1.14191584
104* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.14181203
105SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.13543850
106NCOR1_26117541_ChIP-Seq_K562_Human1.12076865
107* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11581472
108BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11518100
109SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.10523225
110SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.09936080
111RARG_19884340_ChIP-ChIP_MEFs_Mouse1.09619340
112ESR2_21235772_ChIP-Seq_MCF-7_Human1.09206439
113SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09177190
114KDM2B_26808549_Chip-Seq_JURKAT_Human1.09121116
115ELF1_20517297_ChIP-Seq_JURKAT_Human1.08548023
116ELF1_17652178_ChIP-ChIP_JURKAT_Human1.08546230
117IKZF1_21737484_ChIP-ChIP_HCT116_Human1.06253594
118* GATA3_26560356_Chip-Seq_TH2_Human1.04874147
119* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.04105485
120* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02965918
121GATA1_22025678_ChIP-Seq_K562_Human1.01806877
122SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.00761438
123SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.00092330
124GATA2_21666600_ChIP-Seq_HMVEC_Human1.00061542
125BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99097603
126TCF4_22108803_ChIP-Seq_LS180_Human0.99043479
127SUZ12_27294783_Chip-Seq_ESCs_Mouse0.99025085
128EGR1_19032775_ChIP-ChIP_M12_Human0.99011119
129HTT_18923047_ChIP-ChIP_STHdh_Human0.98512019
130GATA2_19941826_ChIP-Seq_K562_Human0.98436679
131EED_16625203_ChIP-ChIP_MESCs_Mouse0.97420256
132* STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.96740917
133CTCF_27219007_Chip-Seq_ERYTHROID_Human0.96628391
134CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.95720382
135* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95307650
136SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.95180131
137SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.95180131
138MTF2_20144788_ChIP-Seq_MESCs_Mouse0.94808124
139GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94554045
140VDR_24787735_ChIP-Seq_THP-1_Human0.94446220
141P300_19829295_ChIP-Seq_ESCs_Human0.93986279
142GATA1_19941827_ChIP-Seq_MEL86_Mouse0.93650874
143PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93587271
144JARID2_20075857_ChIP-Seq_MESCs_Mouse0.92999524
145NR3C1_23031785_ChIP-Seq_PC12_Mouse0.92980376
146* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92901214
147CIITA_25753668_ChIP-Seq_RAJI_Human0.91570741
148P68_20966046_ChIP-Seq_HELA_Human0.90958430
149SPI1_20517297_ChIP-Seq_HL60_Human0.89322717
150CTCF_21964334_ChIP-Seq_BJAB-B_Human0.88591794
151* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.86871034
152EZH2_27304074_Chip-Seq_ESCs_Mouse0.86445840
153SRY_22984422_ChIP-ChIP_TESTIS_Rat0.86305392
154AR_25329375_ChIP-Seq_VCAP_Human0.85330667
155IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.83385978
156EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.83082427
157JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82784746
158CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.80725289
159UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.80448022
160FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.79854906
161JARID2_20064375_ChIP-Seq_MESCs_Mouse0.78791410
162AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.78780410
163THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.78241223
164CLOCK_20551151_ChIP-Seq_293T_Human0.77792499
165TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77560231
166CTBP2_25329375_ChIP-Seq_LNCAP_Human0.77449515
167EZH2_27294783_Chip-Seq_ESCs_Mouse0.76614841
168PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.76170752
169* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.74851750
170TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.74512938
171AHR_22903824_ChIP-Seq_MCF-7_Human0.74349472
172FOXA1_21572438_ChIP-Seq_LNCaP_Human0.73292919
173ESR1_20079471_ChIP-ChIP_T-47D_Human0.73051451
174WT1_19549856_ChIP-ChIP_CCG9911_Human0.72975476
175MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.72954108
176FOXM1_26456572_ChIP-Seq_MCF-7_Human0.72246286
177EP300_21415370_ChIP-Seq_HL-1_Mouse0.71670173
178RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.71645534
179BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.71395428
180RNF2_18974828_ChIP-Seq_MESCs_Mouse0.71201930
181EZH2_18974828_ChIP-Seq_MESCs_Mouse0.71201930
182CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.70463832
183* SMAD4_21799915_ChIP-Seq_A2780_Human0.69991298
184PRDM14_20953172_ChIP-Seq_ESCs_Human0.69955698

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat4.73637085
2MP0002796_impaired_skin_barrier4.61609086
3MP0003303_peritoneal_inflammation4.36151303
4MP0004381_abnormal_hair_follicle3.73508393
5MP0005464_abnormal_platelet_physiology3.29335736
6MP0003941_abnormal_skin_development2.88271318
7MP0005275_abnormal_skin_tensile2.57245259
8MP0002148_abnormal_hypersensitivity_rea2.48507877
9MP0002420_abnormal_adaptive_immunity2.48224441
10MP0001819_abnormal_immune_cell2.45539243
11MP0003763_abnormal_thymus_physiology2.41056708
12MP0005501_abnormal_skin_physiology2.36537088
13MP0001346_abnormal_lacrimal_gland2.33411179
14MP0001835_abnormal_antigen_presentation2.27263573
15MP0003300_gastrointestinal_ulcer2.20346643
16MP0002398_abnormal_bone_marrow2.14094014
17MP0002060_abnormal_skin_morphology2.12459670
18MP0010155_abnormal_intestine_physiology2.06470284
19MP0003195_calcinosis2.03823219
20MP0003436_decreased_susceptibility_to2.01747161
21MP0000716_abnormal_immune_system1.97281933
22MP0001216_abnormal_epidermal_layer1.97083876
23MP0010386_abnormal_urinary_bladder1.87785389
24MP0002138_abnormal_hepatobiliary_system1.86441633
25MP0008260_abnormal_autophagy1.85633827
26MP0003011_delayed_dark_adaptation1.81280116
27MP0000383_abnormal_hair_follicle1.80972879
28MP0003453_abnormal_keratinocyte_physiol1.80614457
29MP0010771_integument_phenotype1.80532411
30MP0009333_abnormal_splenocyte_physiolog1.79552086
31MP0002405_respiratory_system_inflammati1.78842573
32MP0004947_skin_inflammation1.78485757
33MP0002009_preneoplasia1.76525422
34MP0002638_abnormal_pupillary_reflex1.75579301
35MP0000689_abnormal_spleen_morphology1.70901205
36MP0003172_abnormal_lysosome_physiology1.70328732
37MP0009278_abnormal_bone_marrow1.69532753
38MP0009379_abnormal_foot_pigmentation1.68457680
39MP0002277_abnormal_respiratory_mucosa1.65675197
40MP0002429_abnormal_blood_cell1.63761503
41MP0005451_abnormal_body_composition1.63632121
42MP0010234_abnormal_vibrissa_follicle1.61784263
43MP0002722_abnormal_immune_system1.61629637
44MP0000465_gastrointestinal_hemorrhage1.54650372
45MP0000579_abnormal_nail_morphology1.54234434
46MP0002098_abnormal_vibrissa_morphology1.54042002
47MP0001790_abnormal_immune_system1.53307109
48MP0005387_immune_system_phenotype1.53307109
49MP0004782_abnormal_surfactant_physiolog1.53301501
50MP0002090_abnormal_vision1.53296917
51MP0002876_abnormal_thyroid_physiology1.52484465
52MP0005397_hematopoietic_system_phenotyp1.47484703
53MP0001545_abnormal_hematopoietic_system1.47484703
54MP0001851_eye_inflammation1.46437033
55MP0003191_abnormal_cellular_cholesterol1.41433690
56MP0000685_abnormal_immune_system1.39985709
57MP0003724_increased_susceptibility_to1.36950932
58MP0000703_abnormal_thymus_morphology1.36613280
59MP0002163_abnormal_gland_morphology1.35904930
60MP0003828_pulmonary_edema1.35296355
61MP0009785_altered_susceptibility_to1.34503311
62MP0000858_altered_metastatic_potential1.34237783
63MP0000647_abnormal_sebaceous_gland1.33118526
64MP0005085_abnormal_gallbladder_physiolo1.32507687
65MP0010678_abnormal_skin_adnexa1.32463092
66MP0005000_abnormal_immune_tolerance1.31649890
67MP0006082_CNS_inflammation1.31183803
68MP0004019_abnormal_vitamin_homeostasis1.30441990
69MP0000538_abnormal_urinary_bladder1.29375537
70MP0000343_altered_response_to1.28722711
71MP0003183_abnormal_peptide_metabolism1.26524397
72MP0005058_abnormal_lysosome_morphology1.24765211
73MP0002132_abnormal_respiratory_system1.23857294
74MP0002139_abnormal_hepatobiliary_system1.23566430
75MP0005025_abnormal_response_to1.23438435
76MP0003075_altered_response_to1.20493275
77MP0005379_endocrine/exocrine_gland_phen1.20358607
78MP0002998_abnormal_bone_remodeling1.18715665
79MP0000427_abnormal_hair_cycle1.16461269
80MP0002419_abnormal_innate_immunity1.15726681
81MP0003866_abnormal_defecation1.15393385
82MP0005310_abnormal_salivary_gland1.15376156
83MP0009840_abnormal_foam_cell1.12369448
84MP0005360_urolithiasis1.11931062
85MP0003638_abnormal_response/metabolism_1.10512735
86MP0005083_abnormal_biliary_tract1.10455821
87MP0008875_abnormal_xenobiotic_pharmacok1.08506260
88MP0001191_abnormal_skin_condition1.07501436
89MP0002332_abnormal_exercise_endurance1.06708874
90MP0005535_abnormal_body_temperature1.04311377
91MP0000015_abnormal_ear_pigmentation1.03332385
92MP0003656_abnormal_erythrocyte_physiolo1.01357310
93MP0001800_abnormal_humoral_immune0.98396125
94MP0005075_abnormal_melanosome_morpholog0.98020551
95MP0004808_abnormal_hematopoietic_stem0.97072250
96MP0002837_dystrophic_cardiac_calcinosis0.96916109
97MP0009763_increased_sensitivity_to0.96065823
98MP0002166_altered_tumor_susceptibility0.96018100
99MP0002822_catalepsy0.95367467
100MP0002396_abnormal_hematopoietic_system0.95206936
101MP0000377_abnormal_hair_follicle0.93978346
102MP0000604_amyloidosis0.93674951
103MP0005365_abnormal_bile_salt0.92886783
104MP0005166_decreased_susceptibility_to0.91474000
105MP0001984_abnormal_olfaction0.91331436
106MP0001663_abnormal_digestive_system0.89743811
107MP0009764_decreased_sensitivity_to0.89639764
108MP0001533_abnormal_skeleton_physiology0.89486798
109MP0001845_abnormal_inflammatory_respons0.89331306
110MP0001853_heart_inflammation0.86264608
111MP0000013_abnormal_adipose_tissue0.86243644
112MP0008004_abnormal_stomach_pH0.85633580
113MP0009765_abnormal_xenobiotic_induced0.85320111
114MP0003566_abnormal_cell_adhesion0.85199522
115MP0005671_abnormal_response_to0.85083100
116MP0000467_abnormal_esophagus_morphology0.84609746
117MP0005167_abnormal_blood-brain_barrier0.84333357
118MP0002006_tumorigenesis0.84193924
119MP0000249_abnormal_blood_vessel0.82429679
120MP0000490_abnormal_crypts_of0.82407235
121MP0008469_abnormal_protein_level0.82369539
122MP0005332_abnormal_amino_acid0.82367167
123MP0008874_decreased_physiological_sensi0.82286913
124MP0009931_abnormal_skin_appearance0.82176786
125MP0002723_abnormal_immune_serum0.82100629
126MP0010329_abnormal_lipoprotein_level0.80257615
127MP0002452_abnormal_antigen_presenting0.79437603
128MP0005666_abnormal_adipose_tissue0.79379015
129MP0002735_abnormal_chemical_nociception0.79246171
130MP0000367_abnormal_coat/_hair0.79056338
131MP0003136_yellow_coat_color0.77765564
132MP0001243_abnormal_dermal_layer0.77458382
133MP0004185_abnormal_adipocyte_glucose0.77413457
134MP0001666_abnormal_nutrient_absorption0.75409039
135MP0001881_abnormal_mammary_gland0.75028821
136MP0004130_abnormal_muscle_cell0.74634266
137MP0002118_abnormal_lipid_homeostasis0.72853598
138MP0004270_analgesia0.72137166
139MP0006276_abnormal_autonomic_nervous0.71599140
140MP0004510_myositis0.69821692
141MP0003448_altered_tumor_morphology0.69483290
142MP0005551_abnormal_eye_electrophysiolog0.69140655
143MP0002933_joint_inflammation0.68858767
144MP0003690_abnormal_glial_cell0.68008127
145MP0002971_abnormal_brown_adipose0.67630601
146MP0009643_abnormal_urine_homeostasis0.67618835
147MP0004883_abnormal_blood_vessel0.66357464
148MP0002019_abnormal_tumor_incidence0.64908258
149MP0003045_fibrosis0.63768223
150MP0005174_abnormal_tail_pigmentation0.63245079
151MP0005390_skeleton_phenotype0.59899880
152MP0003091_abnormal_cell_migration0.58718530
153MP0009115_abnormal_fat_cell0.57464632
154MP0000609_abnormal_liver_physiology0.50310940
155MP0001873_stomach_inflammation0.50209446
156MP0000920_abnormal_myelination0.48686701
157MP0004036_abnormal_muscle_relaxation0.47481691
158MP0005381_digestive/alimentary_phenotyp0.46767553
159MP0002877_abnormal_melanocyte_morpholog0.45642468
160MP0005164_abnormal_response_to0.45402985

Predicted human phenotypes

RankGene SetZ-score
1Parakeratosis (HP:0001036)4.62316059
2Agammaglobulinemia (HP:0004432)4.52146632
3Prolonged bleeding time (HP:0003010)4.27874157
4Meningitis (HP:0001287)4.15939197
5Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.95857736
6Gastrointestinal stroma tumor (HP:0100723)3.87806180
7Mediastinal lymphadenopathy (HP:0100721)3.87258787
8Purpura (HP:0000979)3.84089485
9Plantar hyperkeratosis (HP:0007556)3.77880426
10Colitis (HP:0002583)3.70145505
11Petechiae (HP:0000967)3.70070779
12Palmoplantar hyperkeratosis (HP:0000972)3.69578209
13Abnormal delayed hypersensitivity skin test (HP:0002963)3.68327598
14Vasculitis (HP:0002633)3.68001487
15Chronic obstructive pulmonary disease (HP:0006510)3.66521762
16Obstructive lung disease (HP:0006536)3.66521762
17Panhypogammaglobulinemia (HP:0003139)3.63462527
18Congenital ichthyosiform erythroderma (HP:0007431)3.62113511
19Spontaneous hematomas (HP:0007420)3.60846404
20Recurrent fungal infections (HP:0002841)3.60344760
21Cellulitis (HP:0100658)3.56307802
22Epistaxis (HP:0000421)3.51591226
23Systemic lupus erythematosus (HP:0002725)3.49171568
24Recurrent viral infections (HP:0004429)3.47956562
25Inflammation of the large intestine (HP:0002037)3.44416076
26Encephalitis (HP:0002383)3.40480947
27Hypotrichosis (HP:0001006)3.39194354
28Gastrointestinal inflammation (HP:0004386)3.38429328
29Recurrent sinusitis (HP:0011108)3.36750685
30Gingival bleeding (HP:0000225)3.31514709
31Abnormal hemoglobin (HP:0011902)3.31318661
32Recurrent skin infections (HP:0001581)3.31177334
33Conjunctival hamartoma (HP:0100780)3.29525007
34Palmar hyperkeratosis (HP:0010765)3.24451864
35Recurrent cutaneous fungal infections (HP:0011370)3.17908395
36Chronic mucocutaneous candidiasis (HP:0002728)3.17908395
37Thick nail (HP:0001805)3.14988748
38Elevated erythrocyte sedimentation rate (HP:0003565)3.13185682
39Eczematoid dermatitis (HP:0000976)3.12048021
40Stomatitis (HP:0010280)3.11856042
41Right ventricular cardiomyopathy (HP:0011663)3.05871251
42Gastrointestinal infarctions (HP:0005244)3.05753186
43Increased IgM level (HP:0003496)2.99816015
44Lip pit (HP:0100267)2.97505289
45Vacuolated lymphocytes (HP:0001922)2.94940342
46Axonal loss (HP:0003447)2.93971391
47Hyporeflexia of lower limbs (HP:0002600)2.91054508
48Increased IgE level (HP:0003212)2.90120723
49Erythema (HP:0010783)2.89794623
50Recurrent bronchitis (HP:0002837)2.87521789
51Abnormality of secondary sexual hair (HP:0009888)2.87280319
52Abnormality of the axillary hair (HP:0100134)2.87280319
53Recurrent bacterial skin infections (HP:0005406)2.85571459
54Xanthomatosis (HP:0000991)2.77137593
55Pulmonary infiltrates (HP:0002113)2.74818860
56Recurrent abscess formation (HP:0002722)2.74233300
57Lymphopenia (HP:0001888)2.71029972
58Woolly hair (HP:0002224)2.70528218
59Keratoconjunctivitis sicca (HP:0001097)2.68062705
60Osteomyelitis (HP:0002754)2.65886298
61Fragile nails (HP:0001808)2.65823715
62Gingivitis (HP:0000230)2.65238291
63Chest pain (HP:0100749)2.59400021
64T lymphocytopenia (HP:0005403)2.54920026
65Abnormal platelet volume (HP:0011876)2.54784463
66Menorrhagia (HP:0000132)2.54290311
67Abnormality of T cells (HP:0002843)2.53548872
68Erythroderma (HP:0001019)2.53334655
69Gangrene (HP:0100758)2.52667485
70Exercise-induced myalgia (HP:0003738)2.52174057
71Hypothermia (HP:0002045)2.51876360
72Natal tooth (HP:0000695)2.51831102
73Abnormality of nail color (HP:0100643)2.51177893
74Abnormality of cells of the lymphoid lineage (HP:0012140)2.51056778
75Arterial thrombosis (HP:0004420)2.50982167
76Epidermoid cyst (HP:0200040)2.50977790
77Complement deficiency (HP:0004431)2.50497022
78Onycholysis (HP:0001806)2.49957207
79IgM deficiency (HP:0002850)2.49777805
80Recurrent pneumonia (HP:0006532)2.48848968
81Recurrent gram-negative bacterial infections (HP:0005420)2.48663343
82Dysostosis multiplex (HP:0000943)2.45432111
83Recurrent lower respiratory tract infections (HP:0002783)2.44922661
84Glomerulonephritis (HP:0000099)2.44501232
85Abnormality of complement system (HP:0005339)2.41460985
86Abnormality of T cell number (HP:0011839)2.41413739
87Restrictive lung disease (HP:0002091)2.37080135
88Pulmonary embolism (HP:0002204)2.35856468
89Emphysema (HP:0002097)2.35377652
90Abnormality of T cell physiology (HP:0011840)2.33235075
91Keratoconjunctivitis (HP:0001096)2.32626608
92Popliteal pterygium (HP:0009756)2.32068007
93Anhidrosis (HP:0000970)2.28855238
94IgA deficiency (HP:0002720)2.28516529
95Chronic otitis media (HP:0000389)2.26733294
96Increased neuronal autofluorescent lipopigment (HP:0002074)2.26369977
97Exercise-induced muscle cramps (HP:0003710)2.26200222
98Corneal erosion (HP:0200020)2.25892951
99Hemoptysis (HP:0002105)2.23796982
100Granulocytopenia (HP:0001913)2.21758514
101Papilloma (HP:0012740)2.21393273
102Verrucae (HP:0200043)2.21393273
103IgG deficiency (HP:0004315)2.21370928
104Distal lower limb muscle weakness (HP:0009053)2.20969902
105Acute necrotizing encephalopathy (HP:0006965)2.20104340
106Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.19985197
107Leukocytosis (HP:0001974)2.19457399
108Loss of speech (HP:0002371)2.19441328
109Abnormality of liposaccharide metabolism (HP:0010968)2.16685583
110Abnormality of glycosphingolipid metabolism (HP:0004343)2.16685583
111Abnormality of glycolipid metabolism (HP:0010969)2.16685583
112Hyperlipoproteinemia (HP:0010980)2.15659422
113Sepsis (HP:0100806)2.14999086
114Abnormal pupillary function (HP:0007686)2.14459757
115Amyloidosis (HP:0011034)2.12782531
116Pustule (HP:0200039)2.11936157
117Increased mean platelet volume (HP:0011877)2.10923794
118Autoimmune hemolytic anemia (HP:0001890)2.10696935
119Calf muscle hypertrophy (HP:0008981)2.08055840
120Fatigue (HP:0012378)2.06725958
121Myocardial infarction (HP:0001658)2.06248125
122Muscle hypertrophy of the lower extremities (HP:0008968)2.05133262
123Nail dystrophy (HP:0008404)2.04319587
124Viral hepatitis (HP:0006562)2.03671679
125Abnormal mitochondria in muscle tissue (HP:0008316)2.03389443
126Increased cerebral lipofuscin (HP:0011813)2.03375751
127Skin rash (HP:0000988)2.03030291
128Joint swelling (HP:0001386)2.03003506
129Hypohidrosis (HP:0000966)2.01456982
130Prolonged partial thromboplastin time (HP:0003645)2.00679479
131Chronic diarrhea (HP:0002028)1.99297955
132Abnormal platelet function (HP:0011869)1.98685834
133Impaired platelet aggregation (HP:0003540)1.98685834
134Thrombocytosis (HP:0001894)1.97833835
135Hypophosphatemic rickets (HP:0004912)1.97713695
136Hepatosplenomegaly (HP:0001433)1.97710794
137Arthralgia (HP:0002829)1.95700080
138Renal Fanconi syndrome (HP:0001994)1.95343294
139Cerebral hemorrhage (HP:0001342)1.95339310
140Abnormality of the pleura (HP:0002103)1.94912813
141Vascular calcification (HP:0004934)1.94264406
142Ketoacidosis (HP:0001993)1.93903780
143Premature loss of primary teeth (HP:0006323)1.93627660
144Autoimmune thrombocytopenia (HP:0001973)1.93169511
145Acute encephalopathy (HP:0006846)1.92728524
146Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.92475456
147Progressive macrocephaly (HP:0004481)1.92281231
148Palmoplantar keratoderma (HP:0000982)1.91553395
149Hypokinesia (HP:0002375)1.90092939
150Ulnar claw (HP:0001178)1.89925867
151Advanced eruption of teeth (HP:0006288)1.87123145
152Joint hemorrhage (HP:0005261)1.87072607
153Abnormality of renal resorption (HP:0011038)1.86927634
154Pruritus (HP:0000989)1.86802413
155Nephritis (HP:0000123)1.86601339
156Milia (HP:0001056)1.86324444
157Type I diabetes mellitus (HP:0100651)1.85469788
158Orchitis (HP:0100796)1.85063223
159Hypoalphalipoproteinemia (HP:0003233)1.84628432
160Abnormality of macrophages (HP:0004311)1.84252382
161Acanthosis nigricans (HP:0000956)1.83818200
162Urticaria (HP:0001025)1.81284779
163Retrobulbar optic neuritis (HP:0100654)1.80608365
164Optic neuritis (HP:0100653)1.80608365
165Ventricular tachycardia (HP:0004756)1.79857475
166Myoglobinuria (HP:0002913)1.79330390
167Cerebral edema (HP:0002181)1.78602226
168Alopecia of scalp (HP:0002293)1.78492547
169Progressive visual loss (HP:0000529)1.77307518
170Areflexia of lower limbs (HP:0002522)1.76716489
171Hypergammaglobulinemia (HP:0010702)1.73849620
172Muscle fiber inclusion bodies (HP:0100299)1.72315676
173Abnormal blistering of the skin (HP:0008066)1.71653928
174Abnormality of aromatic amino acid family metabolism (HP:0004338)1.70358532
175Muscle stiffness (HP:0003552)1.70072664
176Myositis (HP:0100614)1.70043225
177Abnormality of calcium-phosphate metabolism (HP:0100530)1.69561133
178Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.69067681
179Cardiovascular calcification (HP:0011915)1.66967065
180Neuroendocrine neoplasm (HP:0100634)1.66956473
181Hydroxyprolinuria (HP:0003080)1.62436003
182Abnormality of proline metabolism (HP:0010907)1.62436003
183Paralysis (HP:0003470)1.61892883

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST44.31189683
2MAP4K13.90051301
3MAP3K143.55301757
4PRPF4B3.12055894
5MAP3K133.05294646
6TYK22.72103648
7GRK72.62724926
8MST1R2.55054771
9PIK3CG2.32397486
10MAPKAPK32.31402339
11MAP2K32.21707885
12FES2.17885514
13BLK2.10224564
14MAP3K122.08957693
15BTK2.02402062
16MAP3K32.01558482
17BMPR22.00973221
18TRPM71.99129739
19ERBB31.97769625
20CDK191.96385367
21CSF1R1.92206637
22MAP3K21.91134979
23MAPK151.86883091
24BMPR1B1.86205548
25BCR1.80801614
26STK241.76584825
27TAOK31.66715221
28OBSCN1.66164867
29PIM21.64115267
30NME21.62992146
31GRK51.56786901
32KIT1.55812889
33PBK1.54341092
34RIPK41.50931863
35FER1.47392728
36TXK1.45654870
37TBK11.44595966
38MATK1.43801311
39GRK61.33647408
40EPHA31.32963975
41LYN1.31759591
42WNK41.21084250
43FGFR41.19966906
44TAOK21.18069284
45KSR21.17334469
46MAPKAPK51.17188679
47NEK91.15993776
48GRK11.14479300
49INSRR1.14333848
50IKBKB1.06759457
51NTRK11.05882889
52LCK1.05218579
53TEC1.03614366
54DYRK1B1.03007609
55IKBKE1.01353866
56ADRBK11.00937071
57ERN10.97358542
58ADRBK20.95567438
59PDK10.94851459
60JAK10.94448064
61TRIB30.93605731
62BMX0.90989259
63TESK10.90161875
64MARK30.88485060
65FRK0.86173498
66PDPK10.86061313
67CDC42BPA0.85820814
68PRKCE0.84814044
69MET0.83757042
70FGR0.83510082
71CASK0.81606858
72IRAK40.81522947
73MARK20.81491172
74SIK20.79573189
75LRRK20.78761558
76TAOK10.78509057
77MAP2K40.78478339
78EPHB10.78230228
79SYK0.78058094
80SMG10.76506859
81MAPK120.76222882
82JAK20.75174475
83JAK30.75147505
84PKN10.72831243
85TNK20.72475081
86BCKDK0.72248075
87MAP2K10.70324199
88TTN0.69947726
89YES10.68827812
90PIM10.67897050
91LIMK10.67519447
92MAPK70.66952291
93ARAF0.66436004
94MAP3K70.66292812
95MAPKAPK20.65292002
96MAP3K10.63444365
97PTK60.62835525
98CDK40.61858002
99IRAK30.61855998
100MAPK110.61432918
101STK390.59679324
102RET0.58712989
103PTK2B0.57307492
104MAP3K50.57203147
105MAP3K100.56524312
106FYN0.56324115
107RAF10.56237585
108FGFR30.55506723
109MOS0.54408060
110RIPK10.53221234
111IRAK10.53021253
112MAP3K60.52028992
113HCK0.51223152
114EPHB20.50177868
115TESK20.50089315
116PRKCD0.49897117
117ITK0.49779861
118MAP3K110.49559034
119EIF2AK20.48328567
120CHUK0.48018280
121CDK120.47957080
122PHKG20.47260092
123PHKG10.47260092
124MAP2K60.45059557
125HIPK20.44913680
126IGF1R0.44304411
127PLK20.44110786
128ERBB40.43874292
129MINK10.42326127
130NTRK20.41902714
131PDK20.41634878
132PRKD20.41621488
133PRKD10.41337099
134MAPK40.40693204
135MAP3K90.40454340
136PDK40.40287356
137PDK30.40287356
138STK38L0.39764761
139SGK30.38195494
140BRAF0.37342625
141MYLK0.37230926
142TGFBR20.37086526
143RPS6KL10.37039118
144RPS6KC10.37039118
145EGFR0.37001609
146ACVR1B0.36813143
147PRKCQ0.36220519
148CAMKK10.35717466
149PRKAA20.35504003
150EEF2K0.35304644
151RPS6KA20.35073563
152ZAP700.34980654
153SIK30.34758349
154MAP2K20.33645296
155STK100.33565013
156IRAK20.31971304
157CSK0.31617964
158SGK20.31432164

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.89987352
2Phenylalanine metabolism_Homo sapiens_hsa003602.88572793
3B cell receptor signaling pathway_Homo sapiens_hsa046622.66008599
4Staphylococcus aureus infection_Homo sapiens_hsa051502.56754956
5Oxidative phosphorylation_Homo sapiens_hsa001902.48692334
6Histidine metabolism_Homo sapiens_hsa003402.38573404
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.34294769
8Fatty acid elongation_Homo sapiens_hsa000622.08680613
9Tyrosine metabolism_Homo sapiens_hsa003502.07262550
10Viral myocarditis_Homo sapiens_hsa054162.05612415
11Antigen processing and presentation_Homo sapiens_hsa046122.02023497
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.88038540
13Cyanoamino acid metabolism_Homo sapiens_hsa004601.87300796
14Collecting duct acid secretion_Homo sapiens_hsa049661.82256653
15Hematopoietic cell lineage_Homo sapiens_hsa046401.76845967
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.73148951
17Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.69801546
18Sphingolipid metabolism_Homo sapiens_hsa006001.66156248
19Parkinsons disease_Homo sapiens_hsa050121.65752331
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.65582525
21Influenza A_Homo sapiens_hsa051641.60312284
22Acute myeloid leukemia_Homo sapiens_hsa052211.59516594
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.55769528
24Herpes simplex infection_Homo sapiens_hsa051681.50273834
25T cell receptor signaling pathway_Homo sapiens_hsa046601.49870138
26Measles_Homo sapiens_hsa051621.49298488
27Graft-versus-host disease_Homo sapiens_hsa053321.46746424
28Alzheimers disease_Homo sapiens_hsa050101.46633934
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.42718457
30Complement and coagulation cascades_Homo sapiens_hsa046101.42276406
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.40378693
32Allograft rejection_Homo sapiens_hsa053301.40185976
33Fatty acid degradation_Homo sapiens_hsa000711.39811746
34Platelet activation_Homo sapiens_hsa046111.38024580
35Linoleic acid metabolism_Homo sapiens_hsa005911.37601496
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.35968007
37Rheumatoid arthritis_Homo sapiens_hsa053231.33693200
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.30068812
39Phototransduction_Homo sapiens_hsa047441.22579198
40Arachidonic acid metabolism_Homo sapiens_hsa005901.21016886
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.19963563
42Phagosome_Homo sapiens_hsa041451.19388633
43TNF signaling pathway_Homo sapiens_hsa046681.18438496
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17618940
45Jak-STAT signaling pathway_Homo sapiens_hsa046301.14891046
46Arginine biosynthesis_Homo sapiens_hsa002201.13916524
47Chemical carcinogenesis_Homo sapiens_hsa052041.13828869
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.12268791
49PPAR signaling pathway_Homo sapiens_hsa033201.11875674
50Tryptophan metabolism_Homo sapiens_hsa003801.11103165
51Ribosome_Homo sapiens_hsa030101.08237759
52Lysosome_Homo sapiens_hsa041421.07389590
53Peroxisome_Homo sapiens_hsa041461.06688559
54Ether lipid metabolism_Homo sapiens_hsa005651.04586148
55Vibrio cholerae infection_Homo sapiens_hsa051101.03719240
56beta-Alanine metabolism_Homo sapiens_hsa004101.03511957
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.02985643
58Protein export_Homo sapiens_hsa030601.02603946
59Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.00230400
60Non-small cell lung cancer_Homo sapiens_hsa052230.99772307
61Retinol metabolism_Homo sapiens_hsa008300.99312486
62Hepatitis B_Homo sapiens_hsa051610.98651333
63Fatty acid metabolism_Homo sapiens_hsa012120.97689941
64Apoptosis_Homo sapiens_hsa042100.97240510
65Pertussis_Homo sapiens_hsa051330.95597833
66Cardiac muscle contraction_Homo sapiens_hsa042600.93756485
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.93570501
68Pancreatic cancer_Homo sapiens_hsa052120.90237547
69Chronic myeloid leukemia_Homo sapiens_hsa052200.88171182
70Hepatitis C_Homo sapiens_hsa051600.87109151
71Epstein-Barr virus infection_Homo sapiens_hsa051690.87094629
72Shigellosis_Homo sapiens_hsa051310.86306194
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85856186
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.85816128
75Sulfur metabolism_Homo sapiens_hsa009200.83646832
76VEGF signaling pathway_Homo sapiens_hsa043700.82894148
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82508062
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80620057
79Huntingtons disease_Homo sapiens_hsa050160.80332370
80Toll-like receptor signaling pathway_Homo sapiens_hsa046200.77026564
81Renin secretion_Homo sapiens_hsa049240.76580695
82Asthma_Homo sapiens_hsa053100.76392884
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.76335841
84Steroid biosynthesis_Homo sapiens_hsa001000.75537469
85Intestinal immune network for IgA production_Homo sapiens_hsa046720.75261325
86Autoimmune thyroid disease_Homo sapiens_hsa053200.74718752
87HTLV-I infection_Homo sapiens_hsa051660.73471115
88Synaptic vesicle cycle_Homo sapiens_hsa047210.73390656
89Propanoate metabolism_Homo sapiens_hsa006400.73074825
90Pancreatic secretion_Homo sapiens_hsa049720.72812259
91Type I diabetes mellitus_Homo sapiens_hsa049400.72550963
92Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.72287583
93Nitrogen metabolism_Homo sapiens_hsa009100.71326523
94Leishmaniasis_Homo sapiens_hsa051400.70573528
95Caffeine metabolism_Homo sapiens_hsa002320.69675721
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.67195487
97Glycosaminoglycan degradation_Homo sapiens_hsa005310.66573115
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65998982
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.63419672
100African trypanosomiasis_Homo sapiens_hsa051430.63352691
101Butanoate metabolism_Homo sapiens_hsa006500.62669081
102Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.62416466
103Malaria_Homo sapiens_hsa051440.62384117
104Osteoclast differentiation_Homo sapiens_hsa043800.62015423
105Serotonergic synapse_Homo sapiens_hsa047260.61263664
106Endocytosis_Homo sapiens_hsa041440.60893113
107Pyruvate metabolism_Homo sapiens_hsa006200.59429653
108Viral carcinogenesis_Homo sapiens_hsa052030.59384762
109Legionellosis_Homo sapiens_hsa051340.59244632
110Prolactin signaling pathway_Homo sapiens_hsa049170.58793134
111Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56962289
112Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56805406
113Glycerolipid metabolism_Homo sapiens_hsa005610.56185633
114Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55529442
115Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54778806
116NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53889528
117Maturity onset diabetes of the young_Homo sapiens_hsa049500.53364586
118AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52902980
119Choline metabolism in cancer_Homo sapiens_hsa052310.52850336
120Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52661171
121Tuberculosis_Homo sapiens_hsa051520.52596019
122Proteasome_Homo sapiens_hsa030500.52405116
123Dorso-ventral axis formation_Homo sapiens_hsa043200.51653420
124Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51322667
125Mineral absorption_Homo sapiens_hsa049780.50102535
126Systemic lupus erythematosus_Homo sapiens_hsa053220.49899578
127Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49059051
128Fat digestion and absorption_Homo sapiens_hsa049750.48834889
129Renal cell carcinoma_Homo sapiens_hsa052110.47490525
130Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47251640
131NF-kappa B signaling pathway_Homo sapiens_hsa040640.46127635
132mTOR signaling pathway_Homo sapiens_hsa041500.45968096
133GnRH signaling pathway_Homo sapiens_hsa049120.44244169
134HIF-1 signaling pathway_Homo sapiens_hsa040660.44010921
135Steroid hormone biosynthesis_Homo sapiens_hsa001400.42563948
136Notch signaling pathway_Homo sapiens_hsa043300.42286876
137Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42175249
138Toxoplasmosis_Homo sapiens_hsa051450.41990982
139Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.41274279
140Glycerophospholipid metabolism_Homo sapiens_hsa005640.40894530
141Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40720582
142Bile secretion_Homo sapiens_hsa049760.40236051
143Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.39885540
144MAPK signaling pathway_Homo sapiens_hsa040100.39793790
145Insulin resistance_Homo sapiens_hsa049310.38450924
146Endometrial cancer_Homo sapiens_hsa052130.38063001
147Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37810462
148ABC transporters_Homo sapiens_hsa020100.37517586
149Adipocytokine signaling pathway_Homo sapiens_hsa049200.37463691
150Amoebiasis_Homo sapiens_hsa051460.36726108
151Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36588378
152Other glycan degradation_Homo sapiens_hsa005110.36346004
153FoxO signaling pathway_Homo sapiens_hsa040680.36318180
154ErbB signaling pathway_Homo sapiens_hsa040120.35053149
155Inositol phosphate metabolism_Homo sapiens_hsa005620.33433115
156Type II diabetes mellitus_Homo sapiens_hsa049300.33335141
157Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.31893202
158Insulin signaling pathway_Homo sapiens_hsa049100.31311629
159Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.30926984
160Chemokine signaling pathway_Homo sapiens_hsa040620.30895574
161Salmonella infection_Homo sapiens_hsa051320.30043764
162Long-term potentiation_Homo sapiens_hsa047200.29940659
163Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.29600978
164Small cell lung cancer_Homo sapiens_hsa052220.27740779
165Colorectal cancer_Homo sapiens_hsa052100.27500200

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