DUSP21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the dual specificity phosphatase family, specifically the low molecular weight dual specificity phosphatase family. The encoded protein localizes to both the cytoplasm and the nucleus and functions to remove phosphate groups from phosphotyrosine and phosphothreonine residues. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromosome condensation (GO:0030261)9.51842006
2microtubule depolymerization (GO:0007019)9.29944621
3sperm capacitation (GO:0048240)9.20351709
4plasma membrane fusion (GO:0045026)9.13482173
5DNA packaging (GO:0006323)9.10449828
6response to pheromone (GO:0019236)8.22112447
7spermatid development (GO:0007286)8.02476326
8microtubule polymerization or depolymerization (GO:0031109)7.76508103
9single strand break repair (GO:0000012)7.72230585
10sperm-egg recognition (GO:0035036)7.67148875
11spermatid nucleus differentiation (GO:0007289)7.55671938
12protein targeting to Golgi (GO:0000042)7.34078220
13rRNA methylation (GO:0031167)7.25857215
14multicellular organism reproduction (GO:0032504)7.13041576
15protein polyglutamylation (GO:0018095)7.11052841
16binding of sperm to zona pellucida (GO:0007339)7.03944797
17establishment of protein localization to Golgi (GO:0072600)7.03761450
18retrograde transport, vesicle recycling within Golgi (GO:0000301)6.84063481
19calcium ion-dependent exocytosis (GO:0017156)6.70740628
20reproduction (GO:0000003)6.65800155
21spermatogenesis (GO:0007283)6.41728475
22centriole replication (GO:0007099)6.41012379
23male gamete generation (GO:0048232)6.39619471
24negative regulation of inclusion body assembly (GO:0090084)6.38396247
25phosphatidylethanolamine biosynthetic process (GO:0006646)6.30245963
26cell-cell recognition (GO:0009988)6.30183760
27sexual reproduction (GO:0019953)6.29007719
28rRNA modification (GO:0000154)6.09465883
29axonemal dynein complex assembly (GO:0070286)5.96049189
30microtubule severing (GO:0051013)5.85914099
31gamete generation (GO:0007276)5.85890387
32phosphatidylethanolamine metabolic process (GO:0046337)5.81984655
33centriole assembly (GO:0098534)5.65314204
34regulation of centriole replication (GO:0046599)5.28854971
35protein localization to Golgi apparatus (GO:0034067)5.27347049
36cellular ketone body metabolic process (GO:0046950)5.22611163
37regulation of Rab GTPase activity (GO:0032313)5.16758501
38positive regulation of Rab GTPase activity (GO:0032851)5.16758501
39single fertilization (GO:0007338)5.14402772
40seminiferous tubule development (GO:0072520)5.00619073
41regulation of cilium movement (GO:0003352)4.99823662
42motile cilium assembly (GO:0044458)4.85077355
43RNA destabilization (GO:0050779)4.82919925
44cilium or flagellum-dependent cell motility (GO:0001539)4.69255221
45multicellular organismal reproductive process (GO:0048609)4.68351007
46ketone body metabolic process (GO:1902224)4.60416614
47regulation of transcription involved in cell fate commitment (GO:0060850)4.58915559
48regulation of inclusion body assembly (GO:0090083)4.55251773
49germ cell development (GO:0007281)4.52893243
50antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.47856760
51cell wall macromolecule catabolic process (GO:0016998)4.41265212
52cellular process involved in reproduction in multicellular organism (GO:0022412)4.36857763
53fertilization (GO:0009566)4.36693309
54chromatin silencing (GO:0006342)4.25298212
55nucleus organization (GO:0006997)4.21166543
56cell wall macromolecule metabolic process (GO:0044036)4.21000432
57multicellular organismal movement (GO:0050879)3.98768930
58musculoskeletal movement (GO:0050881)3.98768930
59epithelial cilium movement (GO:0003351)3.96937413
60glycerol ether metabolic process (GO:0006662)3.96491029
61glomerular visceral epithelial cell development (GO:0072015)3.92846057
62glomerular epithelial cell development (GO:0072310)3.73387465
63microtubule nucleation (GO:0007020)3.70604268
64coenzyme catabolic process (GO:0009109)3.68612980
65ether metabolic process (GO:0018904)3.65531870
66membrane protein intracellular domain proteolysis (GO:0031293)3.60678440
67organic cation transport (GO:0015695)3.57046130
68protein depolymerization (GO:0051261)3.52858523
69cilium movement (GO:0003341)3.49859361
70negative regulation of Rho protein signal transduction (GO:0035024)3.37849011
71nuclear pore complex assembly (GO:0051292)3.35108467
72peptidyl-threonine dephosphorylation (GO:0035970)3.33417202
73response to acidic pH (GO:0010447)3.26935936
74regulation of microtubule-based movement (GO:0060632)3.24345308
75histone H3-K9 demethylation (GO:0033169)3.22704743
76cellular response to pH (GO:0071467)3.20137608
77cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.17653423
78nucleosome disassembly (GO:0006337)3.15856609
79protein-DNA complex disassembly (GO:0032986)3.15856609
80cerebral cortex neuron differentiation (GO:0021895)3.14316019
81polyamine biosynthetic process (GO:0006596)3.13084177
82Golgi to endosome transport (GO:0006895)3.10636559
83DNA conformation change (GO:0071103)3.08075032
84homeostasis of number of cells within a tissue (GO:0048873)3.07325946
85multicellular organismal development (GO:0007275)3.00537077
86cell recognition (GO:0008037)2.97784366
87regulation of interleukin-13 production (GO:0032656)2.96064795
88negative regulation of gene expression, epigenetic (GO:0045814)2.91868955
89negative regulation of histone methylation (GO:0031061)2.89799635
90detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.89194221
91regulation of T-helper 2 cell differentiation (GO:0045628)2.86354070
92mesenchymal cell differentiation involved in kidney development (GO:0072161)2.82138320
93mesenchymal cell differentiation involved in renal system development (GO:2001012)2.82138320
94mitotic G1 DNA damage checkpoint (GO:0031571)2.81394102
95male meiosis I (GO:0007141)2.80480559
96positive regulation of guanylate cyclase activity (GO:0031284)2.80295322
97intra-Golgi vesicle-mediated transport (GO:0006891)2.77707657
98fusion of sperm to egg plasma membrane (GO:0007342)12.0712258
99acrosome reaction (GO:0007340)11.9810004
100sperm motility (GO:0030317)11.8767035

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.94520659
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.55050268
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.84636933
4TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.53066536
5POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.53066536
6CBP_20019798_ChIP-Seq_JUKART_Human2.26185167
7IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.26185167
8EZH2_22144423_ChIP-Seq_EOC_Human2.18285695
9ELF1_20517297_ChIP-Seq_JURKAT_Human2.17410105
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.11735103
11VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.09233654
12FUS_26573619_Chip-Seq_HEK293_Human2.03754503
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02660076
14ERA_21632823_ChIP-Seq_H3396_Human1.93895947
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.93011136
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.90964640
17* RAC3_21632823_ChIP-Seq_H3396_Human1.90480745
18NANOG_20526341_ChIP-Seq_ESCs_Human1.83051410
19RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.82148704
20EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.81985966
21EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.80793715
22DROSHA_22980978_ChIP-Seq_HELA_Human1.80311102
23CTCF_27219007_Chip-Seq_Bcells_Human1.75614767
24EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.72662707
25WDR5_24793694_ChIP-Seq_LNCAP_Human1.71856836
26BCL6_27268052_Chip-Seq_Bcells_Human1.70954338
27MYC_19829295_ChIP-Seq_ESCs_Human1.70217833
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.70033087
29TAF2_19829295_ChIP-Seq_ESCs_Human1.67520950
30UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.66863675
31E2F1_20622854_ChIP-Seq_HELA_Human1.65611903
32YY1_22570637_ChIP-Seq_MALME-3M_Human1.65030618
33PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.60050044
34SMC4_20622854_ChIP-Seq_HELA_Human1.58014215
35HNFA_21074721_ChIP-Seq_CACO-2_Human1.57341337
36BCOR_27268052_Chip-Seq_Bcells_Human1.57241010
37CBX2_22325352_ChIP-Seq_293T-Rex_Human1.56580370
38SMAD4_21741376_ChIP-Seq_EPCs_Human1.55766987
39ER_23166858_ChIP-Seq_MCF-7_Human1.54691566
40RBPJ_21746931_ChIP-Seq_IB4_Human1.53502662
41P68_20966046_ChIP-Seq_HELA_Human1.53147376
42AUTS2_25519132_ChIP-Seq_293T-REX_Human1.53067000
43CTCF_20526341_ChIP-Seq_ESCs_Human1.52675426
44PHF8_20622854_ChIP-Seq_HELA_Human1.52453711
45CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.51732861
46OCT4_20526341_ChIP-Seq_ESCs_Human1.48333462
47ETV1_20927104_ChIP-Seq_GIST48_Human1.46286815
48ARNT_22903824_ChIP-Seq_MCF-7_Human1.44404769
49TP63_22573176_ChIP-Seq_HFKS_Human1.44090382
50ERG_20517297_ChIP-Seq_VCAP_Human1.40840166
51LXR_22292898_ChIP-Seq_THP-1_Human1.40600098
52ETV2_25802403_ChIP-Seq_MESCs_Mouse1.38593627
53NFYB_21822215_ChIP-Seq_K562_Human1.37579278
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37236894
55P300_27268052_Chip-Seq_Bcells_Human1.37178880
56SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.36244309
57TP53_18474530_ChIP-ChIP_U2OS_Human1.33065297
58SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.32253687
59PHF8_20622853_ChIP-Seq_HELA_Human1.30559465
60SOX2_22085726_ChIP-Seq_NPCs_Mouse1.30509369
61GATA3_21878914_ChIP-Seq_MCF-7_Human1.30382982
62SMAD3_21741376_ChIP-Seq_ESCs_Human1.29922123
63AR_25329375_ChIP-Seq_VCAP_Human1.29820109
64TP63_19390658_ChIP-ChIP_HaCaT_Human1.29486448
65TBL1_22424771_ChIP-Seq_293T_Human1.28213196
66KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.27919227
67GATA6_21074721_ChIP-Seq_CACO-2_Human1.27588844
68CEBPB_22108803_ChIP-Seq_LS180_Human1.27374103
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.26704956
70GATA1_19941826_ChIP-Seq_K562_Human1.26311098
71STAT6_21828071_ChIP-Seq_BEAS2B_Human1.25885521
72P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.24427929
73P53_21459846_ChIP-Seq_SAOS-2_Human1.24072524
74* TDRD3_21172665_ChIP-Seq_MCF-7_Human1.23703250
75RUNX1_26923725_Chip-Seq_HPCs_Mouse1.19951807
76GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.19769384
77EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.19612297
78SA1_27219007_Chip-Seq_Bcells_Human1.17646055
79PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.16590916
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15290470
81GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15130712
82TAF15_26573619_Chip-Seq_HEK293_Human1.14923886
83NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.14838501
84NFYA_21822215_ChIP-Seq_K562_Human1.14571510
85RUNX_20019798_ChIP-Seq_JUKART_Human1.14010020
86P300_19829295_ChIP-Seq_ESCs_Human1.13841190
87SUZ12_27294783_Chip-Seq_ESCs_Mouse1.13139926
88* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.12583272
89ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10884039
90KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08990845
91SMAD4_21741376_ChIP-Seq_HESCs_Human1.08036744
92SMRT_27268052_Chip-Seq_Bcells_Human1.05338861
93NANOG_19829295_ChIP-Seq_ESCs_Human1.03277211
94SOX2_19829295_ChIP-Seq_ESCs_Human1.03277211
95FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01044595
96CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00951238
97ZNF274_21170338_ChIP-Seq_K562_Hela1.00837106
98OCT1_27270436_Chip-Seq_PROSTATE_Human1.00004410
99KLF5_25053715_ChIP-Seq_YYC3_Human0.99753377
100GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99603865

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot5.42302454
2MP0003878_abnormal_ear_physiology5.42302454
3MP0005670_abnormal_white_adipose4.54795810
4MP0003698_abnormal_male_reproductive4.47183887
5MP0001929_abnormal_gametogenesis3.95914853
6MP0001348_abnormal_lacrimal_gland3.31921728
7MP0000678_abnormal_parathyroid_gland2.57721035
8MP0002161_abnormal_fertility/fecundity2.51712719
9MP0003718_maternal_effect2.41269217
10MP0003646_muscle_fatigue2.13744497
11MP0003011_delayed_dark_adaptation2.12778449
12MP0002132_abnormal_respiratory_system2.09065549
13MP0005451_abnormal_body_composition2.01517662
14MP0005410_abnormal_fertilization12.1894200
15MP0002210_abnormal_sex_determination1.83087696
16MP0005379_endocrine/exocrine_gland_phen1.66412828
17MP0001485_abnormal_pinna_reflex1.59892341
18MP0005310_abnormal_salivary_gland1.59032634
19MP0002234_abnormal_pharynx_morphology1.49814826
20MP0005423_abnormal_somatic_nervous1.49451465
21MP0001486_abnormal_startle_reflex1.49064547
22MP0004510_myositis1.48673496
23MP0001145_abnormal_male_reproductive1.48165819
24MP0000653_abnormal_sex_gland1.40291714
25MP0002249_abnormal_larynx_morphology1.37951084
26MP0003879_abnormal_hair_cell1.37556768
27MP0002282_abnormal_trachea_morphology1.36192557
28MP0004742_abnormal_vestibular_system1.29599379
29MP0001765_abnormal_ion_homeostasis1.24496825
30MP0004859_abnormal_synaptic_plasticity1.20753555
31MP0002138_abnormal_hepatobiliary_system1.14413239
32MP0001963_abnormal_hearing_physiology1.10151850
33MP0002822_catalepsy1.08710190
34MP0005083_abnormal_biliary_tract1.07681502
35MP0009053_abnormal_anal_canal1.07125666
36MP0008995_early_reproductive_senescence1.05248702
37MP0002735_abnormal_chemical_nociception1.00878999
38MP0001968_abnormal_touch/_nociception1.00653835
39MP0005395_other_phenotype0.99984185
40MP0009697_abnormal_copulation0.99032171
41MP0000534_abnormal_ureter_morphology0.96414229
42MP0009115_abnormal_fat_cell0.94323053
43MP0000026_abnormal_inner_ear0.93049123
44MP0002127_abnormal_cardiovascular_syste0.91892831
45MP0002229_neurodegeneration0.86556089
46MP0005636_abnormal_mineral_homeostasis0.85428533
47MP0005248_abnormal_Harderian_gland0.80662435
48MP0000955_abnormal_spinal_cord0.79261567
49MP0008877_abnormal_DNA_methylation0.78692328
50MP0005666_abnormal_adipose_tissue0.78626814
51MP0005551_abnormal_eye_electrophysiolog0.77344801
52MP0005167_abnormal_blood-brain_barrier0.75098874
53MP0000681_abnormal_thyroid_gland0.72769154
54MP0004085_abnormal_heartbeat0.72353351
55MP0002733_abnormal_thermal_nociception0.71163579
56MP0008569_lethality_at_weaning0.71061645
57MP0005253_abnormal_eye_physiology0.70890142
58MP0003077_abnormal_cell_cycle0.70121239
59MP0002067_abnormal_sensory_capabilities0.69102419
60MP0004233_abnormal_muscle_weight0.66838447
61MP0005397_hematopoietic_system_phenotyp0.61606981
62MP0001545_abnormal_hematopoietic_system0.61606981
63MP0001905_abnormal_dopamine_level0.60207979
64MP0005375_adipose_tissue_phenotype0.60066255
65MP0000049_abnormal_middle_ear0.58293603
66MP0002557_abnormal_social/conspecific_i0.56412438
67MP0004957_abnormal_blastocyst_morpholog0.54313626
68MP0001666_abnormal_nutrient_absorption0.54147505
69MP0001984_abnormal_olfaction0.53089466
70MP0005408_hypopigmentation0.52325553
71MP0005367_renal/urinary_system_phenotyp0.52146901
72MP0000516_abnormal_urinary_system0.52146901
73MP0005535_abnormal_body_temperature0.51251657
74MP0002572_abnormal_emotion/affect_behav0.49855646
75MP0003137_abnormal_impulse_conducting0.48022345
76MP0001440_abnormal_grooming_behavior0.46865400
77MP0001970_abnormal_pain_threshold0.44134054
78MP0004036_abnormal_muscle_relaxation0.43838712
79MP0003699_abnormal_female_reproductive0.43600244
80MP0004484_altered_response_of0.42102389
81MP0000003_abnormal_adipose_tissue0.41950210
82MP0001879_abnormal_lymphatic_vessel0.41778997
83MP0000230_abnormal_systemic_arterial0.41054621
84MP0002272_abnormal_nervous_system0.39810181
85MP0009764_decreased_sensitivity_to0.38637021
86MP0005332_abnormal_amino_acid0.38532179
87MP0004084_abnormal_cardiac_muscle0.38451983
88MP0002734_abnormal_mechanical_nocicepti0.38251116
89MP0002653_abnormal_ependyma_morphology0.37959239
90MP0006292_abnormal_olfactory_placode0.36993159
91MP0008961_abnormal_basal_metabolism0.34449767
92MP0000249_abnormal_blood_vessel0.33214612
93MP0003172_abnormal_lysosome_physiology0.33082175
94MP0009745_abnormal_behavioral_response0.33005177
95MP0009278_abnormal_bone_marrow0.32801353
96MP0002928_abnormal_bile_duct0.32304954
97MP0003119_abnormal_digestive_system0.32204775
98MP0005391_vision/eye_phenotype0.32101485
99MP0002269_muscular_atrophy0.32003242
100MP0001501_abnormal_sleep_pattern0.31970605

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)8.35043630
2Dynein arm defect of respiratory motile cilia (HP:0012255)5.83695650
3Absent/shortened dynein arms (HP:0200106)5.83695650
4Asymmetric septal hypertrophy (HP:0001670)5.72191375
5Tubulointerstitial nephritis (HP:0001970)5.49921069
6Chronic hepatic failure (HP:0100626)5.02658701
7Bony spicule pigmentary retinopathy (HP:0007737)4.93773479
8Attenuation of retinal blood vessels (HP:0007843)4.91320512
9Male infertility (HP:0003251)4.60329784
10Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.54625966
11Resting tremor (HP:0002322)4.48943254
12Bell-shaped thorax (HP:0001591)4.45630589
13Abnormal ciliary motility (HP:0012262)4.35239881
14Abnormal respiratory motile cilium physiology (HP:0012261)4.32236700
15Hyperkalemia (HP:0002153)4.19373228
16Nasal polyposis (HP:0100582)4.17290200
17Abnormality of macular pigmentation (HP:0008002)4.09714041
18Infertility (HP:0000789)4.06072097
19Cone-rod dystrophy (HP:0000548)4.02424939
20Abnormal respiratory motile cilium morphology (HP:0005938)4.01440095
21Abnormal respiratory epithelium morphology (HP:0012253)4.01440095
22Aplasia/Hypoplasia of the earlobes (HP:0009906)4.00970421
23Enlarged epiphyses (HP:0010580)3.97059414
24Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.95341581
25Hypoplastic ischia (HP:0003175)3.93455377
26Abnormal rod and cone electroretinograms (HP:0008323)3.79545667
27Potter facies (HP:0002009)3.61909464
28Facial shape deformation (HP:0011334)3.61909464
29Abnormality of the ischium (HP:0003174)3.47953450
30Impulsivity (HP:0100710)3.42391575
31Abnormality of the nasal mucosa (HP:0000433)3.37686163
32Hypoplasia of the thymus (HP:0000778)3.30108284
33Abnormal spermatogenesis (HP:0008669)3.28241059
34Hypoalphalipoproteinemia (HP:0003233)3.24875751
35Progressive sensorineural hearing impairment (HP:0000408)3.23540304
36Azoospermia (HP:0000027)3.11528166
37Postural instability (HP:0002172)3.08642088
38Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.06539395
39Abnormality of dental color (HP:0011073)2.94667020
40Menstrual irregularities (HP:0000858)2.87158786
41Generalized aminoaciduria (HP:0002909)2.85010060
42Renovascular hypertension (HP:0100817)2.80966512
43Amelogenesis imperfecta (HP:0000705)2.79137632
44Stage 5 chronic kidney disease (HP:0003774)2.75218456
45Unilateral renal agenesis (HP:0000122)2.73142301
46Truncal obesity (HP:0001956)2.72800532
47Portal hypertension (HP:0001409)2.72257754
48Nephronophthisis (HP:0000090)2.66145019
49Insulin-resistant diabetes mellitus (HP:0000831)2.65662097
50Abnormal urine output (HP:0012590)2.60213821
51Abnormality of the costochondral junction (HP:0000919)2.57407614
52Tubulointerstitial abnormality (HP:0001969)2.55175073
53Rhinitis (HP:0012384)2.54409592
54Progressive cerebellar ataxia (HP:0002073)2.53192667
55Abnormality of the hepatic vasculature (HP:0006707)2.50514734
56Abnormality of the aortic arch (HP:0012303)2.40533073
57Abnormality of potassium homeostasis (HP:0011042)2.37017721
58Double outlet right ventricle (HP:0001719)2.36013036
59Congenital malformation of the right heart (HP:0011723)2.36013036
60Abnormality of the renal medulla (HP:0100957)2.25362277
61Flattened epiphyses (HP:0003071)2.24481973
62Osteomalacia (HP:0002749)2.24465594
63Abnormal drinking behavior (HP:0030082)2.23652034
64Polydipsia (HP:0001959)2.23652034
65Epiphyseal dysplasia (HP:0002656)2.23265155
66Abnormality of renal excretion (HP:0011036)2.22646791
67Progressive hearing impairment (HP:0001730)2.22442398
68Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.21864786
69Absent epiphyses (HP:0010577)2.21864786
70Ventricular tachycardia (HP:0004756)2.20127977
71Focal segmental glomerulosclerosis (HP:0000097)2.19423259
72Increased purine levels (HP:0004368)2.15959602
73Hyperuricemia (HP:0002149)2.15959602
74Upper limb muscle weakness (HP:0003484)2.14774793
75Renal dysplasia (HP:0000110)2.13678958
76Hypophosphatemic rickets (HP:0004912)2.09715990
77Abnormality of the epiphysis of the femoral head (HP:0010574)2.07034331
78Hyperthyroidism (HP:0000836)2.05046161
79Recurrent pneumonia (HP:0006532)2.04328542
80Hyponatremia (HP:0002902)2.04187906
81Polyuria (HP:0000103)2.02809373
82Intellectual disability, moderate (HP:0002342)2.01104704
83Abnormality of the parathyroid morphology (HP:0011766)1.99676017
84Renal Fanconi syndrome (HP:0001994)1.97326983
85Chronic bronchitis (HP:0004469)1.96195049
86Widely patent fontanelles and sutures (HP:0004492)1.95569368
87Hypoparathyroidism (HP:0000829)1.93727935
88Abnormality of femoral epiphyses (HP:0006499)1.93253422
89Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.93253422
90Subcapsular cataract (HP:0000523)1.89595190
91Bronchiectasis (HP:0002110)1.86783286
92Abnormality of the femoral head (HP:0003368)1.83165467
93Abnormality of the pubic bones (HP:0003172)1.83133384
94Decreased central vision (HP:0007663)1.80672409
95Recurrent corneal erosions (HP:0000495)1.80533086
96Atelectasis (HP:0100750)1.80171356
97Sandal gap (HP:0001852)1.79452393
98Bowel incontinence (HP:0002607)1.78937201
99Myokymia (HP:0002411)1.78596019
100Aplasia/Hypoplasia of the sacrum (HP:0008517)1.77623483

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK49.28412691
2TESK15.25375421
3DDR25.02397317
4INSRR4.72173482
5BRD43.55936446
6MAP4K23.42582212
7PLK23.36634560
8PNCK2.81990201
9STK382.71569247
10CAMK1G2.25524450
11PIK3CG2.14868897
12MAPK152.02705693
13PRKD32.00929715
14STK38L1.96369305
15WNK11.65375692
16MST1R1.60095606
17CDK121.52041145
18PDPK11.43127032
19PDK11.39620071
20KSR21.38808337
21NEK61.29048543
22CDK71.24132882
23DYRK1B1.17260681
24TYRO31.14850469
25PTK2B1.10361665
26CAMK1D0.87705707
27AKT30.83540429
28MAP3K20.81516715
29PRKG20.80675542
30BRAF0.79294690
31MAP3K90.77520812
32MAP3K110.68994380
33RIPK40.66000345
34MAP3K80.63173425
35RPS6KA20.60988029
36SIK20.60966523
37PRKG10.59258843
38NTRK30.59221067
39PRKAA20.58411525
40LATS20.56750967
41MAP2K20.54477603
42RPS6KA10.53694231
43UHMK10.50653673
44WNK40.49947899
45CDK30.49058045
46CDK20.48219289
47ROCK10.48012433
48CAMK10.47345387
49CDK10.44079409
50GSK3B0.42264901
51MAP3K10.41063554
52BRSK10.39974657
53LATS10.39671416
54TIE10.39101916
55MAPK10.39001274
56CDK40.38111661
57JAK30.38000402
58MAP3K40.34757548
59MTOR0.34402116
60CHEK10.33697008
61RPS6KC10.32768060
62RPS6KL10.32768060
63MUSK0.32553209
64MAPK80.30830443
65CAMK40.28814604
66RPS6KA60.28703668
67MARK10.28247690
68PRKCG0.28130294
69ARAF0.27272242
70BRSK20.24554574
71PRKCB0.23453159
72PRKCZ0.23138642
73SGK10.22836437
74BLK0.22374017
75MAPK100.22346798
76MARK20.22082249
77MAPK140.21906700
78SGK2230.21714394
79SGK4940.21714394
80STK390.21647026
81MAPK110.18658750
82TESK20.18035739
83AKT10.16816584
84TNIK0.15943592
85DYRK30.15004051
86BMPR1B0.14056885
87MET0.10596912
88ICK0.09760607
89PKN10.09484270
90MAP3K70.08945685
91PRKACB0.07028943
92JAK20.06956478
93MAP2K10.06918337
94NEK20.06688743
95PRKACA0.06153528
96PRKAA10.05808874
97MAPK90.05571376
98RPS6KA30.03789789
99TRPM70.01317685
100CAMK2A0.00577056

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.61526138
2Fatty acid biosynthesis_Homo sapiens_hsa000616.49700045
3Olfactory transduction_Homo sapiens_hsa047404.04358462
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.88065141
5Butanoate metabolism_Homo sapiens_hsa006502.58239048
6Glycerophospholipid metabolism_Homo sapiens_hsa005642.03680114
7RNA transport_Homo sapiens_hsa030132.02790708
8Type II diabetes mellitus_Homo sapiens_hsa049301.84882506
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.82223566
10Dorso-ventral axis formation_Homo sapiens_hsa043201.71810804
11Taste transduction_Homo sapiens_hsa047421.69150611
12Phenylalanine metabolism_Homo sapiens_hsa003601.65528233
13Fatty acid metabolism_Homo sapiens_hsa012121.62459853
14Fatty acid degradation_Homo sapiens_hsa000711.59208952
15Type I diabetes mellitus_Homo sapiens_hsa049401.57391865
16Allograft rejection_Homo sapiens_hsa053301.55252338
17Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.54960327
18Autoimmune thyroid disease_Homo sapiens_hsa053201.49879121
19Antigen processing and presentation_Homo sapiens_hsa046121.47275159
20Graft-versus-host disease_Homo sapiens_hsa053321.37451775
21Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.33586844
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.29900125
23Adipocytokine signaling pathway_Homo sapiens_hsa049201.23858080
24Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.14329462
25Arginine biosynthesis_Homo sapiens_hsa002201.10562974
26Protein digestion and absorption_Homo sapiens_hsa049741.10108766
27Viral myocarditis_Homo sapiens_hsa054161.09734815
28Arginine and proline metabolism_Homo sapiens_hsa003301.08742217
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.04888867
30Inositol phosphate metabolism_Homo sapiens_hsa005620.95912240
31Endocytosis_Homo sapiens_hsa041440.95266578
32Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.92754567
33Influenza A_Homo sapiens_hsa051640.92588872
34Synaptic vesicle cycle_Homo sapiens_hsa047210.92074120
35Phototransduction_Homo sapiens_hsa047440.91946806
36Oocyte meiosis_Homo sapiens_hsa041140.89735606
37Salivary secretion_Homo sapiens_hsa049700.88912681
38Cardiac muscle contraction_Homo sapiens_hsa042600.82816236
39ABC transporters_Homo sapiens_hsa020100.82583363
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.81352620
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80640882
42Calcium signaling pathway_Homo sapiens_hsa040200.78687632
43Morphine addiction_Homo sapiens_hsa050320.77666384
44VEGF signaling pathway_Homo sapiens_hsa043700.75985872
45PPAR signaling pathway_Homo sapiens_hsa033200.75334437
46Fat digestion and absorption_Homo sapiens_hsa049750.75310938
47Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74249009
48Nicotine addiction_Homo sapiens_hsa050330.73816905
49cAMP signaling pathway_Homo sapiens_hsa040240.73339138
50Primary bile acid biosynthesis_Homo sapiens_hsa001200.71786808
51Maturity onset diabetes of the young_Homo sapiens_hsa049500.71534401
52Renin-angiotensin system_Homo sapiens_hsa046140.69784540
53Tyrosine metabolism_Homo sapiens_hsa003500.68886535
54Selenocompound metabolism_Homo sapiens_hsa004500.67484945
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62174966
56Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62033330
57Acute myeloid leukemia_Homo sapiens_hsa052210.61311544
58mRNA surveillance pathway_Homo sapiens_hsa030150.59722344
59Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58121367
60Estrogen signaling pathway_Homo sapiens_hsa049150.57056972
61Retinol metabolism_Homo sapiens_hsa008300.56581353
62Biosynthesis of amino acids_Homo sapiens_hsa012300.53725705
63Purine metabolism_Homo sapiens_hsa002300.53030905
64Glycerolipid metabolism_Homo sapiens_hsa005610.51338061
65Circadian entrainment_Homo sapiens_hsa047130.51265972
66Glutamatergic synapse_Homo sapiens_hsa047240.49800806
67Fanconi anemia pathway_Homo sapiens_hsa034600.49676604
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48346427
69Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.46562895
70Basal transcription factors_Homo sapiens_hsa030220.45795516
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42961154
72Bile secretion_Homo sapiens_hsa049760.42948474
73Hedgehog signaling pathway_Homo sapiens_hsa043400.39362445
74Jak-STAT signaling pathway_Homo sapiens_hsa046300.39278563
75MAPK signaling pathway_Homo sapiens_hsa040100.38432512
76Serotonergic synapse_Homo sapiens_hsa047260.37013162
77Gastric acid secretion_Homo sapiens_hsa049710.36787948
78Prolactin signaling pathway_Homo sapiens_hsa049170.33965508
79Insulin secretion_Homo sapiens_hsa049110.33623608
80Pancreatic secretion_Homo sapiens_hsa049720.31948019
81Renin secretion_Homo sapiens_hsa049240.31737973
82Cholinergic synapse_Homo sapiens_hsa047250.31665228
83Long-term potentiation_Homo sapiens_hsa047200.30476841
84Herpes simplex infection_Homo sapiens_hsa051680.28999971
85Huntingtons disease_Homo sapiens_hsa050160.27931739
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.27650919
87Carbon metabolism_Homo sapiens_hsa012000.26363250
88Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.25160418
89Viral carcinogenesis_Homo sapiens_hsa052030.25077628
90B cell receptor signaling pathway_Homo sapiens_hsa046620.25069137
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24868025
92Nitrogen metabolism_Homo sapiens_hsa009100.23241246
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.23021073
94GABAergic synapse_Homo sapiens_hsa047270.22534755
95Tight junction_Homo sapiens_hsa045300.21311048
96HIF-1 signaling pathway_Homo sapiens_hsa040660.18433545
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.18089942
98AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.17677756
99Oxytocin signaling pathway_Homo sapiens_hsa049210.15442687
100Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.15356198

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