DUS4L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.69752893
2DNA unwinding involved in DNA replication (GO:0006268)5.19436465
3maturation of SSU-rRNA (GO:0030490)5.14104278
4viral transcription (GO:0019083)5.10846398
5translational termination (GO:0006415)5.02052752
6DNA strand elongation involved in DNA replication (GO:0006271)4.93278962
7nucleobase biosynthetic process (GO:0046112)4.85606710
8folic acid-containing compound biosynthetic process (GO:0009396)4.80316924
9DNA deamination (GO:0045006)4.68040528
10telomere maintenance via semi-conservative replication (GO:0032201)4.66130387
11DNA strand elongation (GO:0022616)4.64971372
12translational elongation (GO:0006414)4.63662434
13formation of translation preinitiation complex (GO:0001731)4.56075412
14ribosomal small subunit biogenesis (GO:0042274)4.54641770
15DNA replication initiation (GO:0006270)4.40153685
16IMP biosynthetic process (GO:0006188)4.31535967
17SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.26041356
18IMP metabolic process (GO:0046040)4.25053831
19translational initiation (GO:0006413)4.21616630
20nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.21556118
21purine nucleobase biosynthetic process (GO:0009113)4.19764024
22cotranslational protein targeting to membrane (GO:0006613)4.16919704
23protein targeting to ER (GO:0045047)4.14490928
24telomere maintenance via recombination (GO:0000722)4.06178815
25establishment of protein localization to endoplasmic reticulum (GO:0072599)3.94706416
26histone exchange (GO:0043486)3.92495825
27cellular protein complex disassembly (GO:0043624)3.91726458
28protein localization to endoplasmic reticulum (GO:0070972)3.91088834
29ribonucleoprotein complex biogenesis (GO:0022613)3.86728953
30folic acid metabolic process (GO:0046655)3.82478945
31ribosomal large subunit biogenesis (GO:0042273)3.81770889
32viral life cycle (GO:0019058)3.81746106
33mitotic metaphase plate congression (GO:0007080)3.79062738
34protein-cofactor linkage (GO:0018065)3.74883800
35mitotic recombination (GO:0006312)3.73998071
36pseudouridine synthesis (GO:0001522)3.71456005
37ribosome biogenesis (GO:0042254)3.70698243
38telomere maintenance via telomere lengthening (GO:0010833)3.70282790
39somatic hypermutation of immunoglobulin genes (GO:0016446)3.70014989
40somatic diversification of immune receptors via somatic mutation (GO:0002566)3.70014989
41ribosome assembly (GO:0042255)3.68931184
42synapsis (GO:0007129)3.63017892
43protein localization to kinetochore (GO:0034501)3.61209735
44metaphase plate congression (GO:0051310)3.60548006
45mitotic nuclear envelope disassembly (GO:0007077)3.60038832
46mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.58738691
47rRNA processing (GO:0006364)3.58465348
48negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.58289276
49kinetochore organization (GO:0051383)3.58197327
50protein complex disassembly (GO:0043241)3.55744453
51negative regulation of RNA splicing (GO:0033119)3.51771891
52proteasome assembly (GO:0043248)3.49944532
53regulation of helicase activity (GO:0051095)3.46164811
54pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.45214232
55nucleotide-excision repair, DNA gap filling (GO:0006297)3.44211668
56rRNA metabolic process (GO:0016072)3.44169525
57DNA replication checkpoint (GO:0000076)3.43766344
58DNA double-strand break processing (GO:0000729)3.43481765
59macromolecular complex disassembly (GO:0032984)3.40340193
60mitotic sister chromatid segregation (GO:0000070)3.40152319
61nuclear-transcribed mRNA catabolic process (GO:0000956)3.39391723
62kinetochore assembly (GO:0051382)3.38416842
63pteridine-containing compound biosynthetic process (GO:0042559)3.36258550
64exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.31350564
65sister chromatid segregation (GO:0000819)3.30151709
66nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.30121688
67spliceosomal snRNP assembly (GO:0000387)3.29471409
68establishment of protein localization to mitochondrial membrane (GO:0090151)3.29127101
69resolution of meiotic recombination intermediates (GO:0000712)3.29107964
70nuclear envelope disassembly (GO:0051081)3.27692479
71membrane disassembly (GO:0030397)3.27692479
72attachment of spindle microtubules to kinetochore (GO:0008608)3.27288328
73regulation of protein heterodimerization activity (GO:0043497)3.27252480
74DNA ligation (GO:0006266)3.27132460
75translation (GO:0006412)3.25393560
76CENP-A containing nucleosome assembly (GO:0034080)3.25105587
77regulation of centriole replication (GO:0046599)3.24973168
78chromatin remodeling at centromere (GO:0031055)3.24513799
79negative regulation of DNA recombination (GO:0045910)3.24216610
80establishment of integrated proviral latency (GO:0075713)3.24162112
81mRNA catabolic process (GO:0006402)3.21840574
82DNA replication-dependent nucleosome assembly (GO:0006335)3.20475826
83DNA replication-dependent nucleosome organization (GO:0034723)3.20475826
84pyrimidine nucleoside monophosphate metabolic process (GO:0009129)3.20362819
85RNA catabolic process (GO:0006401)3.15339379
86DNA catabolic process, exonucleolytic (GO:0000738)3.14838506
87regulation of translational fidelity (GO:0006450)3.14068867
88nuclear pore organization (GO:0006999)3.07244793
89cellular component biogenesis (GO:0044085)3.06218645
90DNA replication-independent nucleosome organization (GO:0034724)3.06096068
91DNA replication-independent nucleosome assembly (GO:0006336)3.06096068
92non-recombinational repair (GO:0000726)3.05233526
93double-strand break repair via nonhomologous end joining (GO:0006303)3.05233526
94regulation of mitochondrial translation (GO:0070129)3.03596649
95regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.02637984
96ATP synthesis coupled proton transport (GO:0015986)3.02464567
97energy coupled proton transport, down electrochemical gradient (GO:0015985)3.02464567
98negative regulation of mRNA processing (GO:0050686)3.01964638
99organelle disassembly (GO:1903008)3.01807770
100pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)3.01081447
101UMP metabolic process (GO:0046049)3.01081447
102pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)3.01081447
103UMP biosynthetic process (GO:0006222)3.01081447
104regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.99080079
105regulation of mitotic spindle checkpoint (GO:1903504)2.99080079
106deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.96992349
107tetrahydrofolate metabolic process (GO:0046653)2.96606247
108centriole replication (GO:0007099)2.95853449
109DNA duplex unwinding (GO:0032508)2.95634650
110translesion synthesis (GO:0019985)2.95122661
111regulation of centrosome cycle (GO:0046605)2.95033829
112anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.94735256
113mismatch repair (GO:0006298)2.94209440
114mitochondrial respiratory chain complex I assembly (GO:0032981)2.93784701
115NADH dehydrogenase complex assembly (GO:0010257)2.93784701
116mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.93784701
117negative regulation of DNA-dependent DNA replication (GO:2000104)2.92949065
118DNA geometric change (GO:0032392)2.92697617
119pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.92607970
120protein neddylation (GO:0045116)2.90948223
121L-serine metabolic process (GO:0006563)2.90061793
122protein localization to chromosome, centromeric region (GO:0071459)2.89745763
123L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.89578199
124negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.86651875
125meiotic chromosome segregation (GO:0045132)2.86634641
126rRNA modification (GO:0000154)2.86201636
127establishment of chromosome localization (GO:0051303)2.85983584
128nuclear pore complex assembly (GO:0051292)2.85859302
129isotype switching (GO:0045190)2.85365633
130somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.85365633
131somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.85365633
132folic acid-containing compound metabolic process (GO:0006760)2.84144785
133regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.81920969
134viral mRNA export from host cell nucleus (GO:0046784)2.80579267
135cullin deneddylation (GO:0010388)2.80497825
136postreplication repair (GO:0006301)2.80381861
137termination of RNA polymerase II transcription (GO:0006369)2.79459460
138establishment of viral latency (GO:0019043)2.78557670
139replication fork processing (GO:0031297)2.78158981
140mitochondrial respiratory chain complex assembly (GO:0033108)2.77995035
141protein complex biogenesis (GO:0070271)2.77779072
142regulation of DNA endoreduplication (GO:0032875)2.77672477
143mRNA splicing, via spliceosome (GO:0000398)2.77025085
144RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.77025085
145spindle checkpoint (GO:0031577)2.76991477
146telomere maintenance (GO:0000723)2.75914853
147DNA topological change (GO:0006265)2.75870375
148cell cycle G1/S phase transition (GO:0044843)2.75547223
149G1/S transition of mitotic cell cycle (GO:0000082)2.75547223
150negative regulation of mRNA metabolic process (GO:1903312)2.74764235
151RNA splicing, via transesterification reactions (GO:0000375)2.74476500
152tRNA aminoacylation for protein translation (GO:0006418)2.74380238
153amino acid activation (GO:0043038)2.74329475
154tRNA aminoacylation (GO:0043039)2.74329475
155spliceosomal complex assembly (GO:0000245)2.74281686
156telomere organization (GO:0032200)2.73874037
157chromosome segregation (GO:0007059)2.73807755
158chaperone-mediated protein transport (GO:0072321)2.72970336
159mitotic spindle checkpoint (GO:0071174)2.71195454
160negative regulation of sister chromatid segregation (GO:0033046)2.70879783
161negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.70879783
162negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.70879783
163negative regulation of mitotic sister chromatid segregation (GO:0033048)2.70879783
164negative regulation of mitotic sister chromatid separation (GO:2000816)2.70879783
165negative regulation of chromosome segregation (GO:0051985)2.70400373
166mitotic G2/M transition checkpoint (GO:0044818)2.68419624
167regulation of spindle organization (GO:0090224)2.67641068
168pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.66890577
169protein K6-linked ubiquitination (GO:0085020)2.65517251
170ribonucleoprotein complex disassembly (GO:0032988)2.64758840

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.25163871
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.58358802
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.39541727
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.23449492
5MYC_19079543_ChIP-ChIP_MESCs_Mouse2.99739413
6* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.92127276
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.90569601
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.80953013
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.78871842
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.76736436
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.73896260
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.67078063
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.65346097
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.49778421
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.48311544
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.48028694
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.46967557
18XRN2_22483619_ChIP-Seq_HELA_Human2.38201701
19VDR_23849224_ChIP-Seq_CD4+_Human2.31468520
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.30950981
21MYC_22102868_ChIP-Seq_BL_Human2.24592745
22VDR_22108803_ChIP-Seq_LS180_Human2.23173900
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.21675857
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.19480063
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.17984541
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.14943761
27FOXP3_21729870_ChIP-Seq_TREG_Human2.10050404
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.08950997
29* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.00839108
30DCP1A_22483619_ChIP-Seq_HELA_Human2.00349143
31TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.00280263
32EWS_26573619_Chip-Seq_HEK293_Human1.98468159
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.97049157
34AR_21909140_ChIP-Seq_LNCAP_Human1.91406417
35E2F1_21310950_ChIP-Seq_MCF-7_Human1.86885970
36GABP_19822575_ChIP-Seq_HepG2_Human1.85886430
37THAP11_20581084_ChIP-Seq_MESCs_Mouse1.84258293
38FUS_26573619_Chip-Seq_HEK293_Human1.81754218
39MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78414709
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.77872412
41TTF2_22483619_ChIP-Seq_HELA_Human1.73913553
42CIITA_25753668_ChIP-Seq_RAJI_Human1.73236549
43* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.69535837
44RBPJ_22232070_ChIP-Seq_NCS_Mouse1.69291749
45EGR1_19374776_ChIP-ChIP_THP-1_Human1.68515531
46ZNF274_21170338_ChIP-Seq_K562_Hela1.67265754
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65640127
48* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.64596813
49* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.62862448
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.60620827
51ERG_20887958_ChIP-Seq_HPC-7_Mouse1.59933829
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.56801050
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.55095640
54SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.55091309
55VDR_21846776_ChIP-Seq_THP-1_Human1.51474203
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51344957
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.50760130
58SRF_21415370_ChIP-Seq_HL-1_Mouse1.48769224
59ELK1_19687146_ChIP-ChIP_HELA_Human1.47405366
60KDM5A_27292631_Chip-Seq_BREAST_Human1.45052189
61IGF1R_20145208_ChIP-Seq_DFB_Human1.44975984
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.42057773
63* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.39320683
64PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.34727588
65YY1_21170310_ChIP-Seq_MESCs_Mouse1.33057647
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30354221
67SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.30104034
68FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.29412130
69KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.28819730
70GATA1_22025678_ChIP-Seq_K562_Human1.28326776
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28121364
72IRF1_19129219_ChIP-ChIP_H3396_Human1.28035077
73NANOG_18555785_ChIP-Seq_MESCs_Mouse1.25700300
74CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24317043
75GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.22609170
76MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.20851456
77* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.18954328
78TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18482858
79MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.17376509
80CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.13544785
81SPI1_23547873_ChIP-Seq_NB4_Human1.13228322
82E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11629068
83ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.11262844
84KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10544313
85STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09447432
86SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.07621834
87CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07102077
88POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07091962
89SCL_19346495_ChIP-Seq_HPC-7_Human1.06127268
90* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05880340
91GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05494127
92SOX2_16153702_ChIP-ChIP_HESCs_Human1.04350598
93MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.02305083
94DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01226296
95MYC_18940864_ChIP-ChIP_HL60_Human1.01121097
96IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.01017762
97CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.00563605
98MYB_21317192_ChIP-Seq_ERMYB_Mouse1.00530608
99TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00254385
100E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.99838507
101TP63_19390658_ChIP-ChIP_HaCaT_Human0.99464206
102BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99241744
103ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.98437682
104SOX2_18555785_ChIP-Seq_MESCs_Mouse0.98289139
105TFEB_21752829_ChIP-Seq_HELA_Human0.97579263
106POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.95536481
107PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.94844082
108NANOG_16153702_ChIP-ChIP_HESCs_Human0.94822509
109* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94793409
110RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.94247316
111GATA1_22383799_ChIP-Seq_G1ME_Mouse0.93434941
112* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.93428257
113CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.93192029
114CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.92463377
115DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.92432009
116STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.91714071
117TAF15_26573619_Chip-Seq_HEK293_Human0.91448757
118UTX_26944678_Chip-Seq_JUKART_Human0.90441853
119* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.89611546
120* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.86402375
121MAF_26560356_Chip-Seq_TH1_Human0.83812908
122ZFP57_27257070_Chip-Seq_ESCs_Mouse0.83179711
123* MYB_26560356_Chip-Seq_TH2_Human0.82605958
124HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.82342572
125CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.81335221
126GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.81175871
127NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.80897133
128CTBP1_25329375_ChIP-Seq_LNCAP_Human0.79963667
129ELK1_22589737_ChIP-Seq_MCF10A_Human0.78976516
130P300_19829295_ChIP-Seq_ESCs_Human0.78321239
131SOX17_20123909_ChIP-Seq_XEN_Mouse0.76450537
132TP53_22573176_ChIP-Seq_HFKS_Human0.74209457
133CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.74090588
134GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.73392673
135TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.69893840
136CTBP2_25329375_ChIP-Seq_LNCAP_Human0.67340368

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.66502922
2MP0004957_abnormal_blastocyst_morpholog4.25401910
3MP0010094_abnormal_chromosome_stability4.20868278
4MP0002396_abnormal_hematopoietic_system3.95190396
5MP0008057_abnormal_DNA_replication3.94934989
6MP0003806_abnormal_nucleotide_metabolis3.54096982
7MP0003077_abnormal_cell_cycle3.45840318
8MP0003111_abnormal_nucleus_morphology3.31729819
9MP0006292_abnormal_olfactory_placode3.15900253
10MP0008058_abnormal_DNA_repair2.80301117
11MP0006072_abnormal_retinal_apoptosis2.51633481
12MP0008007_abnormal_cellular_replicative2.37609800
13MP0002102_abnormal_ear_morphology2.33229003
14MP0000490_abnormal_crypts_of2.21863289
15MP0003121_genomic_imprinting2.20413321
16MP0001730_embryonic_growth_arrest2.12675890
17MP0006054_spinal_hemorrhage2.11245660
18MP0000350_abnormal_cell_proliferation2.06244558
19MP0001545_abnormal_hematopoietic_system2.00470686
20MP0005397_hematopoietic_system_phenotyp2.00470686
21MP0010352_gastrointestinal_tract_polyps1.98839725
22MP0003763_abnormal_thymus_physiology1.97047923
23MP0008789_abnormal_olfactory_epithelium1.95023671
24MP0008932_abnormal_embryonic_tissue1.91322229
25MP0003656_abnormal_erythrocyte_physiolo1.90012356
26MP0009333_abnormal_splenocyte_physiolog1.88663328
27MP0003123_paternal_imprinting1.86176608
28MP0001293_anophthalmia1.85747528
29MP0002398_abnormal_bone_marrow1.79942906
30MP0003122_maternal_imprinting1.78594616
31MP0006036_abnormal_mitochondrial_physio1.78388583
32MP0003787_abnormal_imprinting1.77522897
33MP0004808_abnormal_hematopoietic_stem1.76571577
34MP0003136_yellow_coat_color1.67231121
35MP0000689_abnormal_spleen_morphology1.65107220
36MP0001529_abnormal_vocalization1.63378322
37MP0002019_abnormal_tumor_incidence1.62593464
38MP0009379_abnormal_foot_pigmentation1.61536130
39MP0002722_abnormal_immune_system1.59632263
40MP0000703_abnormal_thymus_morphology1.52485947
41MP0001853_heart_inflammation1.51734401
42MP0005499_abnormal_olfactory_system1.50164801
43MP0005394_taste/olfaction_phenotype1.50164801
44MP0002080_prenatal_lethality1.47684366
45MP0001697_abnormal_embryo_size1.46741125
46MP0000313_abnormal_cell_death1.45970455
47MP0000685_abnormal_immune_system1.45596132
48MP0003186_abnormal_redox_activity1.45205444
49MP0001929_abnormal_gametogenesis1.43291167
50MP0003937_abnormal_limbs/digits/tail_de1.41650190
51MP0005075_abnormal_melanosome_morpholog1.41232829
52MP0001286_abnormal_eye_development1.39967036
53MP0002938_white_spotting1.38980653
54MP0000372_irregular_coat_pigmentation1.38573304
55MP0002429_abnormal_blood_cell1.38024357
56MP0005253_abnormal_eye_physiology1.36114053
57MP0002166_altered_tumor_susceptibility1.33898896
58MP0002234_abnormal_pharynx_morphology1.33178524
59MP0008877_abnormal_DNA_methylation1.32734410
60MP0003221_abnormal_cardiomyocyte_apopto1.30848494
61MP0003786_premature_aging1.29496486
62MP0005395_other_phenotype1.28037163
63MP0005380_embryogenesis_phenotype1.27593843
64MP0001672_abnormal_embryogenesis/_devel1.27593843
65MP0003567_abnormal_fetal_cardiomyocyte1.27143973
66MP0000716_abnormal_immune_system1.27124664
67MP0000631_abnormal_neuroendocrine_gland1.26686243
68MP0005365_abnormal_bile_salt1.25602855
69MP0006035_abnormal_mitochondrial_morpho1.25558112
70MP0000653_abnormal_sex_gland1.25371066
71MP0003984_embryonic_growth_retardation1.25172471
72MP0001145_abnormal_male_reproductive1.24965903
73MP0001800_abnormal_humoral_immune1.24536960
74MP0002088_abnormal_embryonic_growth/wei1.20810350
75MP0005671_abnormal_response_to1.20774018
76MP0002233_abnormal_nose_morphology1.19556060
77MP0010307_abnormal_tumor_latency1.19331177
78MP0000358_abnormal_cell_content/1.16885268
79MP0002086_abnormal_extraembryonic_tissu1.16171471
80MP0009697_abnormal_copulation1.15649956
81MP0001835_abnormal_antigen_presentation1.15309905
82MP0005551_abnormal_eye_electrophysiolog1.14798720
83MP0002638_abnormal_pupillary_reflex1.13408184
84MP0005360_urolithiasis1.12284639
85MP0003011_delayed_dark_adaptation1.11649795
86MP0005266_abnormal_metabolism1.10798165
87MP0004197_abnormal_fetal_growth/weight/1.09639407
88MP0006276_abnormal_autonomic_nervous1.08923222
89MP0001984_abnormal_olfaction1.08494738
90MP0003890_abnormal_embryonic-extraembry1.07600725
91MP0005646_abnormal_pituitary_gland1.07199855
92MP0002420_abnormal_adaptive_immunity1.06773385
93MP0005084_abnormal_gallbladder_morpholo1.06221524
94MP0004142_abnormal_muscle_tone1.05517030
95MP0002697_abnormal_eye_size1.05509888
96MP0009046_muscle_twitch1.03606441
97MP0001819_abnormal_immune_cell1.02692150
98MP0002085_abnormal_embryonic_tissue1.01478332
99MP0005391_vision/eye_phenotype1.01443617
100MP0003698_abnormal_male_reproductive1.00617016
101MP0000049_abnormal_middle_ear1.00200982
102MP0002084_abnormal_developmental_patter0.99980843
103MP0002723_abnormal_immune_serum0.99048711
104MP0008995_early_reproductive_senescence0.98417913
105MP0003119_abnormal_digestive_system0.98140938
106MP0010030_abnormal_orbit_morphology0.98030382
107MP0000465_gastrointestinal_hemorrhage0.97172847
108MP0002132_abnormal_respiratory_system0.96944575
109MP0002006_tumorigenesis0.96908692
110MP0002139_abnormal_hepatobiliary_system0.95443563
111MP0003436_decreased_susceptibility_to0.93934227
112MP0005464_abnormal_platelet_physiology0.92373375
113MP0002452_abnormal_antigen_presenting0.91345446
114MP0005085_abnormal_gallbladder_physiolo0.89881119
115MP0000598_abnormal_liver_morphology0.89842488
116MP0002837_dystrophic_cardiac_calcinosis0.88671013
117MP0004147_increased_porphyrin_level0.88570624
118MP0001188_hyperpigmentation0.87331417
119MP0005025_abnormal_response_to0.86927202
120MP0002095_abnormal_skin_pigmentation0.86487635
121MP0001119_abnormal_female_reproductive0.86172912
122MP0009785_altered_susceptibility_to0.85824397
123MP0000778_abnormal_nervous_system0.84915450
124MP0000647_abnormal_sebaceous_gland0.84264574
125MP0008875_abnormal_xenobiotic_pharmacok0.83979430
126MP0002653_abnormal_ependyma_morphology0.81805330
127MP0003718_maternal_effect0.79966193
128MP0005083_abnormal_biliary_tract0.79142750
129MP0000858_altered_metastatic_potential0.79116966
130MP0002161_abnormal_fertility/fecundity0.78672660
131MP0000609_abnormal_liver_physiology0.77337691
132MP0002111_abnormal_tail_morphology0.76961421
133MP0009703_decreased_birth_body0.76605984
134MP0003861_abnormal_nervous_system0.76535017
135MP0003755_abnormal_palate_morphology0.75650224
136MP0003866_abnormal_defecation0.75631102
137MP0010155_abnormal_intestine_physiology0.75546824
138MP0009672_abnormal_birth_weight0.75061916
139MP0005408_hypopigmentation0.74541583
140MP0004133_heterotaxia0.74358942
141MP0001915_intracranial_hemorrhage0.73582681
142MP0002751_abnormal_autonomic_nervous0.73038345
143MP0005384_cellular_phenotype0.72597436
144MP0002160_abnormal_reproductive_system0.72202659
145MP0000477_abnormal_intestine_morphology0.72199122
146MP0008873_increased_physiological_sensi0.71950568
147MP0003938_abnormal_ear_development0.71234229
148MP0002405_respiratory_system_inflammati0.70297628
149MP0005645_abnormal_hypothalamus_physiol0.69375847
150MP0003941_abnormal_skin_development0.68539071
151MP0005319_abnormal_enzyme/_coenzyme0.66746652
152MP0002210_abnormal_sex_determination0.65986537
153MP0005000_abnormal_immune_tolerance0.64971866
154MP0005195_abnormal_posterior_eye0.64839967
155MP0008469_abnormal_protein_level0.64739152
156MP0003699_abnormal_female_reproductive0.64598268
157MP0001845_abnormal_inflammatory_respons0.62828203
158MP0005023_abnormal_wound_healing0.62090943
159MP0001764_abnormal_homeostasis0.62066990

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)6.27122546
2Abnormal number of erythroid precursors (HP:0012131)6.17963086
3Reticulocytopenia (HP:0001896)4.81611697
4Thrombocytosis (HP:0001894)4.29067449
5Aplastic anemia (HP:0001915)4.25101774
6Abnormality of the labia minora (HP:0012880)4.09567585
7Oral leukoplakia (HP:0002745)4.08764000
8Abnormality of the heme biosynthetic pathway (HP:0010472)3.98997976
9Birth length less than 3rd percentile (HP:0003561)3.96213242
10Pallor (HP:0000980)3.69562946
11Macrocytic anemia (HP:0001972)3.64351720
12Colon cancer (HP:0003003)3.46111120
13Chromosomal breakage induced by crosslinking agents (HP:0003221)3.18887135
14Chromsome breakage (HP:0040012)3.12725711
15Selective tooth agenesis (HP:0001592)3.06667937
16True hermaphroditism (HP:0010459)3.01909486
17IgM deficiency (HP:0002850)3.01310471
18Agnosia (HP:0010524)2.86257739
19Acute necrotizing encephalopathy (HP:0006965)2.84218628
20Pancreatic fibrosis (HP:0100732)2.81197978
21Meckel diverticulum (HP:0002245)2.80973180
22Acute encephalopathy (HP:0006846)2.80800330
23Abnormality of reticulocytes (HP:0004312)2.78789016
24Pendular nystagmus (HP:0012043)2.77217767
25Abnormal lung lobation (HP:0002101)2.74920832
26Pancreatic cysts (HP:0001737)2.72238881
27Abnormality of the ileum (HP:0001549)2.70868433
28Aplasia/Hypoplasia of the uvula (HP:0010293)2.69573532
29Ependymoma (HP:0002888)2.68218886
30Hepatocellular necrosis (HP:0001404)2.63772265
31Cerebral hypomyelination (HP:0006808)2.60311927
32Abnormality of pyrimidine metabolism (HP:0004353)2.59184797
33Hepatic necrosis (HP:0002605)2.55216406
34Myelodysplasia (HP:0002863)2.55191718
35Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.55137151
36Decreased activity of mitochondrial respiratory chain (HP:0008972)2.55137151
37Cortical dysplasia (HP:0002539)2.49861140
38Multiple enchondromatosis (HP:0005701)2.49009597
39Microretrognathia (HP:0000308)2.48887171
40Increased serum lactate (HP:0002151)2.47230842
41Chronic otitis media (HP:0000389)2.42094269
42Abnormality of midbrain morphology (HP:0002418)2.42011449
43Molar tooth sign on MRI (HP:0002419)2.42011449
44Basal cell carcinoma (HP:0002671)2.41860727
45Aplasia/Hypoplasia of the tongue (HP:0010295)2.40738839
4611 pairs of ribs (HP:0000878)2.40689151
47Pancytopenia (HP:0001876)2.39257487
483-Methylglutaconic aciduria (HP:0003535)2.35280817
49Amaurosis fugax (HP:0100576)2.30397030
50Renal Fanconi syndrome (HP:0001994)2.28230410
51Progressive macrocephaly (HP:0004481)2.28129140
52Elevated erythrocyte sedimentation rate (HP:0003565)2.27777795
53Poikiloderma (HP:0001029)2.26744533
54Spastic diplegia (HP:0001264)2.24939785
55Lymphoma (HP:0002665)2.24833259
56Small intestinal stenosis (HP:0012848)2.24794111
57Duodenal stenosis (HP:0100867)2.24794111
58Increased CSF lactate (HP:0002490)2.23675799
59Chronic hepatic failure (HP:0100626)2.22967176
60Medial flaring of the eyebrow (HP:0010747)2.17746048
61Breast hypoplasia (HP:0003187)2.17261311
62Hyperbilirubinemia (HP:0002904)2.15794656
63Supernumerary spleens (HP:0009799)2.14486335
64Abnormality of T cell physiology (HP:0011840)2.14423573
65Abnormal hair whorl (HP:0010721)2.13924478
66Acanthocytosis (HP:0001927)2.12043350
67Abnormality of the duodenum (HP:0002246)2.11737168
68Hypobetalipoproteinemia (HP:0003563)2.11560512
69Lipid accumulation in hepatocytes (HP:0006561)2.11470349
70Sloping forehead (HP:0000340)2.10304995
71Congenital primary aphakia (HP:0007707)2.09626509
72Megaloblastic anemia (HP:0001889)2.09596857
73Abnormality of alanine metabolism (HP:0010916)2.08950695
74Hyperalaninemia (HP:0003348)2.08950695
75Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.08950695
76Triphalangeal thumb (HP:0001199)2.08908064
77Postaxial foot polydactyly (HP:0001830)2.07908952
78Aplasia/Hypoplasia of the sacrum (HP:0008517)2.06334865
79Cerebral edema (HP:0002181)2.06121761
80Volvulus (HP:0002580)2.04618531
81Muscle fiber atrophy (HP:0100295)2.04302238
82Increased serum pyruvate (HP:0003542)2.03165020
83Abnormality of glycolysis (HP:0004366)2.03165020
84Premature graying of hair (HP:0002216)2.02960205
85Hyperglycinemia (HP:0002154)2.01993066
86Median cleft lip (HP:0000161)2.01926852
87Nephroblastoma (Wilms tumor) (HP:0002667)2.01911241
88Increased hepatocellular lipid droplets (HP:0006565)2.01775958
89Abnormality of T cells (HP:0002843)2.01265755
90Respiratory difficulties (HP:0002880)2.01123074
91Absent thumb (HP:0009777)2.01028080
92Petechiae (HP:0000967)1.99413654
93Abnormality of monocarboxylic acid metabolism (HP:0010996)1.99036906
94Impaired platelet aggregation (HP:0003540)1.98800649
95Abnormal platelet function (HP:0011869)1.98800649
96Gait imbalance (HP:0002141)1.98730127
97Medulloblastoma (HP:0002885)1.98677626
98Rough bone trabeculation (HP:0100670)1.98583562
99Postnatal microcephaly (HP:0005484)1.96702687
100Mitochondrial inheritance (HP:0001427)1.95684133
101Abnormality of the preputium (HP:0100587)1.95317739
102Cellular immunodeficiency (HP:0005374)1.94888480
103Abnormal number of incisors (HP:0011064)1.94597106
104Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.93711790
105Septo-optic dysplasia (HP:0100842)1.93372652
106Self-mutilation (HP:0000742)1.92787083
107Increased intramyocellular lipid droplets (HP:0012240)1.92350073
108Increased serum ferritin (HP:0003281)1.90273498
109Bile duct proliferation (HP:0001408)1.90175699
110Abnormal biliary tract physiology (HP:0012439)1.90175699
111Abnormality of chromosome stability (HP:0003220)1.90062979
112Focal motor seizures (HP:0011153)1.89541315
113Progressive muscle weakness (HP:0003323)1.89363747
114Increased muscle lipid content (HP:0009058)1.89178644
115Nephrogenic diabetes insipidus (HP:0009806)1.88709921
116Panhypogammaglobulinemia (HP:0003139)1.88472972
117Lactic acidosis (HP:0003128)1.88030479
118Anencephaly (HP:0002323)1.87926684
119Neoplasm of the pancreas (HP:0002894)1.87866069
120Neoplasm of the oral cavity (HP:0100649)1.86602154
121Sclerocornea (HP:0000647)1.86296364
122Squamous cell carcinoma (HP:0002860)1.84683492
123Embryonal renal neoplasm (HP:0011794)1.84610950
124Oligodactyly (HP:0012165)1.83949738
125Facial hemangioma (HP:0000329)1.83815687
126Rhabdomyosarcoma (HP:0002859)1.83224938
127Degeneration of anterior horn cells (HP:0002398)1.81742239
128Abnormality of the anterior horn cell (HP:0006802)1.81742239
129Ragged-red muscle fibers (HP:0003200)1.81500974
130Entropion (HP:0000621)1.81091417
131Hypoplasia of the uterus (HP:0000013)1.80993972
132Preaxial hand polydactyly (HP:0001177)1.80749471
133Oligodactyly (hands) (HP:0001180)1.80212653
134Bone marrow hypocellularity (HP:0005528)1.80116657
135Hypoplasia of the thymus (HP:0000778)1.79954749
136Slender long bone (HP:0003100)1.78960681
137Recurrent viral infections (HP:0004429)1.77945469
138Aplasia/hypoplasia of the uterus (HP:0008684)1.77911141
139Type I transferrin isoform profile (HP:0003642)1.77732976
140Intestinal atresia (HP:0011100)1.77398439
141Rhabdomyolysis (HP:0003201)1.77159728
142Reduced antithrombin III activity (HP:0001976)1.76309795
143Poor coordination (HP:0002370)1.75946155
144Poikilocytosis (HP:0004447)1.75372502
145CNS hypomyelination (HP:0003429)1.74745051
146Abnormal mitochondria in muscle tissue (HP:0008316)1.74008581
147Abnormality of iron homeostasis (HP:0011031)1.73471286
148Patellar aplasia (HP:0006443)1.72811903
149Male pseudohermaphroditism (HP:0000037)1.72684713
150Gonadotropin excess (HP:0000837)1.72238698
151Nephronophthisis (HP:0000090)1.71584135
152Type 2 muscle fiber atrophy (HP:0003554)1.69794618
153Prominent nose (HP:0000448)1.69288727
154CNS demyelination (HP:0007305)1.67911142
155Recurrent bronchitis (HP:0002837)1.67869002
156Exercise intolerance (HP:0003546)1.67566246
157Premature ovarian failure (HP:0008209)1.67136366
158Microvesicular hepatic steatosis (HP:0001414)1.67011954
159Pulmonary fibrosis (HP:0002206)1.66985052
160Acute myeloid leukemia (HP:0004808)1.66869792
161Atrophy/Degeneration involving motor neurons (HP:0007373)1.66848492
162Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.65951723
163Genital tract atresia (HP:0001827)1.65682229
164Poor suck (HP:0002033)1.65380164
165Neoplasm of the colon (HP:0100273)1.65289324
166Oculomotor apraxia (HP:0000657)1.64621566
167Postaxial hand polydactyly (HP:0001162)1.63616728
168Abnormality of the carotid arteries (HP:0005344)1.62703733
169Aganglionic megacolon (HP:0002251)1.62560571
170Short thumb (HP:0009778)1.60564819
171Carpal bone hypoplasia (HP:0001498)1.60076958

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.94772370
2WEE13.78742612
3EIF2AK13.05233926
4BUB12.98292849
5CDK192.94022437
6EEF2K2.74652703
7ACVR1B2.65290679
8ZAK2.59058917
9NME22.47456789
10TSSK62.44553338
11NUAK12.36473407
12MAP4K22.24643152
13SRPK12.23648630
14MAP4K12.21082976
15EIF2AK32.20679627
16FLT32.11995641
17VRK22.10357522
18RPS6KB22.06761771
19PBK2.05191239
20NEK11.98281652
21SCYL21.91596095
22PASK1.90730339
23WNK31.79832644
24VRK11.78350536
25STK101.76514825
26NEK21.75807650
27TGFBR11.72664037
28BCR1.70570193
29MAP3K101.70020797
30MAP3K41.64381178
31BRSK21.62412596
32LRRK21.55126795
33RPS6KA41.52262178
34BMPR1B1.48406538
35CDK71.47152043
36MKNK11.46537230
37TRIM281.45890317
38ATR1.45089524
39STK391.43922589
40CDK41.40109749
41TTK1.39600500
42STK161.36620396
43TESK21.36326625
44TEC1.35532200
45PINK11.34101191
46TLK11.33584038
47PKN21.33581578
48DYRK31.32965418
49MAP2K31.30085365
50PIM21.27747915
51PLK11.27342637
52MAP3K81.23982957
53BTK1.23453209
54CSNK1G11.20608909
55AURKB1.20320307
56MAP3K61.14946678
57TNIK1.13482449
58KIT1.10355793
59PLK41.09905170
60WNK41.08445536
61CSF1R1.05366605
62MAP2K71.02829451
63ZAP701.01720483
64TAF10.97951104
65CHEK10.96936182
66DYRK20.95906843
67PLK30.95752193
68ERBB30.94849616
69BCKDK0.93759124
70NME10.92585328
71CSNK1G20.89739459
72BRSK10.89666146
73GRK60.89660843
74CHEK20.86654941
75CSNK1A1L0.86066430
76DAPK10.84383068
77MST40.82809067
78PAK40.82646027
79CSNK2A20.82004715
80CCNB10.81247772
81PIM10.81139999
82PLK20.77486089
83STK40.76623853
84AURKA0.76205653
85ITK0.75116459
86ILK0.74909715
87PNCK0.73645535
88KDR0.71982103
89MKNK20.71787587
90SYK0.71485739
91CDK60.69910504
92CDK20.66800100
93MAPKAPK30.66325920
94JAK30.65850227
95ATM0.65622217
96RAF10.63914248
97TYK20.63487866
98PDK40.63099351
99PDK30.63099351
100MAP3K110.63028714
101PDK20.62815680
102CDK80.59831605
103CLK10.59813508
104CDK120.58763869
105SIK30.57938037
106CSNK2A10.56749887
107ALK0.56596234
108OXSR10.55484434
109STK30.55467442
110PAK20.54225844
111RPS6KA50.47519132
112MAP2K60.46931314
113PRKCI0.45980625
114MAP2K40.45978378
115KSR10.45495084
116LYN0.45009831
117BRAF0.44816485
118MAP3K120.43765697
119MAPK40.43194970
120CSNK1E0.42449768
121ARAF0.42196242
122CSNK1G30.41793074
123PRKCE0.41700652
124GRK10.41346539
125MAPK130.41282788
126LCK0.39671214
127ABL20.39560926
128PAK10.37664687
129MINK10.37044189
130CDK10.36991308
131UHMK10.36770380
132MELK0.36527460
133PRKCG0.35165910
134MAPK110.35108485
135AKT20.34009534
136PAK30.32791792
137TRIB30.31628203
138CDK30.30802363
139TAOK30.30239214
140MAP3K50.29532478
141NLK0.28815317
142CDK140.28303224
143JAK20.27913047
144EIF2AK20.27457205
145EPHA20.27096112
146NEK60.27070011
147MTOR0.26244598
148MET0.25497211
149CDK180.23688648

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.05699132
2Ribosome_Homo sapiens_hsa030104.23717254
3Mismatch repair_Homo sapiens_hsa034304.09741511
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.43431285
5Spliceosome_Homo sapiens_hsa030403.02460261
6RNA polymerase_Homo sapiens_hsa030202.91392681
7One carbon pool by folate_Homo sapiens_hsa006702.90762255
8Proteasome_Homo sapiens_hsa030502.88565551
9Base excision repair_Homo sapiens_hsa034102.73984888
10RNA transport_Homo sapiens_hsa030132.70982139
11Nucleotide excision repair_Homo sapiens_hsa034202.63575225
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.58309991
13Pyrimidine metabolism_Homo sapiens_hsa002402.55342318
14Oxidative phosphorylation_Homo sapiens_hsa001902.26847767
15Homologous recombination_Homo sapiens_hsa034402.19349870
16Cell cycle_Homo sapiens_hsa041102.02859703
17Non-homologous end-joining_Homo sapiens_hsa034501.96070806
18RNA degradation_Homo sapiens_hsa030181.76660316
19Steroid biosynthesis_Homo sapiens_hsa001001.69867124
20Cysteine and methionine metabolism_Homo sapiens_hsa002701.59487626
21Biosynthesis of amino acids_Homo sapiens_hsa012301.48520497
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.48300527
23Pentose phosphate pathway_Homo sapiens_hsa000301.44072435
24Fatty acid elongation_Homo sapiens_hsa000621.42188989
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.40857103
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.38153108
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.37513386
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.35145172
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.33143135
30Fanconi anemia pathway_Homo sapiens_hsa034601.28096431
31Selenocompound metabolism_Homo sapiens_hsa004501.27506652
32Basal transcription factors_Homo sapiens_hsa030221.27489789
33Purine metabolism_Homo sapiens_hsa002301.19241987
34Vitamin B6 metabolism_Homo sapiens_hsa007501.17697736
35Alzheimers disease_Homo sapiens_hsa050101.12976935
36Caffeine metabolism_Homo sapiens_hsa002321.12939046
37Carbon metabolism_Homo sapiens_hsa012001.12609394
38mRNA surveillance pathway_Homo sapiens_hsa030151.11713931
39Folate biosynthesis_Homo sapiens_hsa007901.10132605
40Systemic lupus erythematosus_Homo sapiens_hsa053221.06177227
41Sulfur relay system_Homo sapiens_hsa041221.04922650
42p53 signaling pathway_Homo sapiens_hsa041151.04603963
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.04432769
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.01579643
45Protein export_Homo sapiens_hsa030600.99810238
46Primary immunodeficiency_Homo sapiens_hsa053400.97863395
47Epstein-Barr virus infection_Homo sapiens_hsa051690.97561147
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.96756537
49Antigen processing and presentation_Homo sapiens_hsa046120.92590103
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91254874
51Herpes simplex infection_Homo sapiens_hsa051680.90116370
52Butanoate metabolism_Homo sapiens_hsa006500.89730001
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88828676
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.84736788
55Viral carcinogenesis_Homo sapiens_hsa052030.75965236
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72221831
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70400228
58Pyruvate metabolism_Homo sapiens_hsa006200.65306390
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64708531
60N-Glycan biosynthesis_Homo sapiens_hsa005100.64699157
61Primary bile acid biosynthesis_Homo sapiens_hsa001200.61018002
62Sulfur metabolism_Homo sapiens_hsa009200.60120606
63Thyroid cancer_Homo sapiens_hsa052160.57530392
64Legionellosis_Homo sapiens_hsa051340.55650614
65Cardiac muscle contraction_Homo sapiens_hsa042600.55572508
66Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55133078
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55132496
68Glutathione metabolism_Homo sapiens_hsa004800.53619063
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50349532
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47913400
71Regulation of autophagy_Homo sapiens_hsa041400.46244093
72Propanoate metabolism_Homo sapiens_hsa006400.44632070
73HTLV-I infection_Homo sapiens_hsa051660.44229805
74Phototransduction_Homo sapiens_hsa047440.43025591
75Shigellosis_Homo sapiens_hsa051310.42627684
76TGF-beta signaling pathway_Homo sapiens_hsa043500.42144265
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41728513
78Fatty acid metabolism_Homo sapiens_hsa012120.39610670
79Parkinsons disease_Homo sapiens_hsa050120.39259984
80Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39183855
81Fatty acid degradation_Homo sapiens_hsa000710.39047722
82Metabolic pathways_Homo sapiens_hsa011000.37452504
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37115712
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36555065
85Renin-angiotensin system_Homo sapiens_hsa046140.36428991
86Oocyte meiosis_Homo sapiens_hsa041140.34274621
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33780529
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33434922
89Olfactory transduction_Homo sapiens_hsa047400.32352034
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32087380
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.31897601
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31873467
93Hematopoietic cell lineage_Homo sapiens_hsa046400.30916292
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30821876
95Tyrosine metabolism_Homo sapiens_hsa003500.29830837
96Huntingtons disease_Homo sapiens_hsa050160.29492314
97beta-Alanine metabolism_Homo sapiens_hsa004100.29476809
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28968845
99Retinol metabolism_Homo sapiens_hsa008300.27822941
100Apoptosis_Homo sapiens_hsa042100.27341589
101RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.26995332
102Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26719211
103Galactose metabolism_Homo sapiens_hsa000520.26410553
104Nicotine addiction_Homo sapiens_hsa050330.26351946
105Measles_Homo sapiens_hsa051620.26274253
106Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.26212908
107Hepatitis B_Homo sapiens_hsa051610.25969796
108Small cell lung cancer_Homo sapiens_hsa052220.25691387
109B cell receptor signaling pathway_Homo sapiens_hsa046620.25487880
110Peroxisome_Homo sapiens_hsa041460.24858263
111NF-kappa B signaling pathway_Homo sapiens_hsa040640.24505797
112Nitrogen metabolism_Homo sapiens_hsa009100.24178911
113Acute myeloid leukemia_Homo sapiens_hsa052210.23433774
114Hippo signaling pathway_Homo sapiens_hsa043900.22927093
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.22835791
116Fructose and mannose metabolism_Homo sapiens_hsa000510.21913307
117Basal cell carcinoma_Homo sapiens_hsa052170.21679746
118Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.21167405
119Arginine and proline metabolism_Homo sapiens_hsa003300.21060231
120Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.20943016
121Lysine degradation_Homo sapiens_hsa003100.20152245
122Colorectal cancer_Homo sapiens_hsa052100.20135706
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.20007943
124Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.17537569
125Arginine biosynthesis_Homo sapiens_hsa002200.17243410
126Taste transduction_Homo sapiens_hsa047420.16055233
127Hedgehog signaling pathway_Homo sapiens_hsa043400.15547093
128Maturity onset diabetes of the young_Homo sapiens_hsa049500.15392993
129Viral myocarditis_Homo sapiens_hsa054160.13869497
130Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.13751847
131Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.13584634
132Alcoholism_Homo sapiens_hsa050340.11951522

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