DUS1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)6.91796481
2DNA deamination (GO:0045006)5.72758124
3proline metabolic process (GO:0006560)5.70578633
4transcription from mitochondrial promoter (GO:0006390)5.17376337
5GDP-mannose metabolic process (GO:0019673)4.70026327
6mannose metabolic process (GO:0006013)4.62878947
7negative regulation of erythrocyte differentiation (GO:0045647)4.48091149
8embryonic process involved in female pregnancy (GO:0060136)4.44596110
9ribosomal small subunit biogenesis (GO:0042274)4.32262232
10negative regulation of fatty acid biosynthetic process (GO:0045717)4.20939764
11replication fork processing (GO:0031297)4.18952970
12sulfur amino acid catabolic process (GO:0000098)4.13977282
13mitochondrial DNA metabolic process (GO:0032042)4.13672188
14formation of translation preinitiation complex (GO:0001731)4.06762184
15somatic diversification of immune receptors via somatic mutation (GO:0002566)4.02641994
16somatic hypermutation of immunoglobulin genes (GO:0016446)4.02641994
17telomere maintenance via semi-conservative replication (GO:0032201)4.01250440
18glycine metabolic process (GO:0006544)3.90250698
19regulation of translational fidelity (GO:0006450)3.90237570
20apoptotic process involved in morphogenesis (GO:0060561)3.88592630
21maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.81890794
22negative regulation of cell size (GO:0045792)3.80646341
23glutamine family amino acid biosynthetic process (GO:0009084)3.78651157
24DNA strand elongation involved in DNA replication (GO:0006271)3.78085481
25regulation of mammary gland epithelial cell proliferation (GO:0033599)3.77651488
26mRNA cleavage (GO:0006379)3.77626208
27mitotic G1 DNA damage checkpoint (GO:0031571)3.68474517
28L-phenylalanine metabolic process (GO:0006558)3.67390728
29erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.67390728
30oxidative demethylation (GO:0070989)3.59580090
31positive regulation of protein homooligomerization (GO:0032464)3.58915025
32folic acid-containing compound biosynthetic process (GO:0009396)3.58354197
33DNA strand elongation (GO:0022616)3.56746186
34serine family amino acid biosynthetic process (GO:0009070)3.48826183
35glyoxylate metabolic process (GO:0046487)3.46762600
36establishment of apical/basal cell polarity (GO:0035089)3.46354145
37modulation by virus of host process (GO:0019054)3.41751731
38regulation of protein homooligomerization (GO:0032462)3.39237352
39serine family amino acid catabolic process (GO:0009071)3.37453562
40spliceosomal tri-snRNP complex assembly (GO:0000244)3.34996558
41serine family amino acid metabolic process (GO:0009069)3.32747502
42mitochondrial RNA metabolic process (GO:0000959)3.31821949
43positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.31509758
44DNA strand renaturation (GO:0000733)3.27860412
45telomere maintenance via recombination (GO:0000722)3.27540551
46mitotic G1/S transition checkpoint (GO:0044819)3.27112544
47regulation of chromatin binding (GO:0035561)3.25406264
48mitotic chromosome condensation (GO:0007076)3.25133925
49nucleotide-excision repair, DNA gap filling (GO:0006297)3.23440870
50folic acid metabolic process (GO:0046655)3.22119213
51dosage compensation (GO:0007549)3.20921458
52base-excision repair (GO:0006284)3.19801662
53negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.16078326
54viral mRNA export from host cell nucleus (GO:0046784)3.15783506
55L-phenylalanine catabolic process (GO:0006559)3.15439527
56erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.15439527
57modulation by symbiont of host cellular process (GO:0044068)3.11594554
58ribosome biogenesis (GO:0042254)3.10952366
59pteridine-containing compound biosynthetic process (GO:0042559)3.10220315
603-UTR-mediated mRNA stabilization (GO:0070935)3.09793932
61cysteine metabolic process (GO:0006534)3.09213338
62negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.08774154
63activation of Rac GTPase activity (GO:0032863)3.07512634
64nucleobase biosynthetic process (GO:0046112)3.07227947
65G1 DNA damage checkpoint (GO:0044783)3.05953110
66UV protection (GO:0009650)3.05577180
67maternal placenta development (GO:0001893)3.04849175
68L-serine metabolic process (GO:0006563)3.04117190
69positive regulation of Cdc42 GTPase activity (GO:0043089)3.00953397
70regulation of histone H3-K27 methylation (GO:0061085)2.99993257
71Golgi transport vesicle coating (GO:0048200)2.99042785
72COPI coating of Golgi vesicle (GO:0048205)2.99042785
73snRNA metabolic process (GO:0016073)2.97939320
74regulation of integrin activation (GO:0033623)2.97922700
75NIK/NF-kappaB signaling (GO:0038061)2.97820382
76nucleotide salvage (GO:0043173)2.97152180
77heme transport (GO:0015886)2.95406184
78regulation of early endosome to late endosome transport (GO:2000641)2.94431209
79termination of RNA polymerase II transcription (GO:0006369)2.93815968
80telomere maintenance via telomere lengthening (GO:0010833)2.93463026
81very-low-density lipoprotein particle assembly (GO:0034379)2.93236701
82tetrahydrofolate metabolic process (GO:0046653)2.91961673
83establishment of protein localization to mitochondrial membrane (GO:0090151)2.91145849
84aromatic amino acid family catabolic process (GO:0009074)2.88797100
85DNA replication initiation (GO:0006270)2.88697318
86purine nucleobase biosynthetic process (GO:0009113)2.88412663
87negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.88406579
88mitotic recombination (GO:0006312)2.88393684
89kynurenine metabolic process (GO:0070189)2.85147006
90negative regulation of fatty acid metabolic process (GO:0045922)2.83754352
91double-strand break repair via nonhomologous end joining (GO:0006303)2.83119803
92non-recombinational repair (GO:0000726)2.83119803
93mRNA stabilization (GO:0048255)2.82259431
94RNA stabilization (GO:0043489)2.82259431
95establishment of monopolar cell polarity (GO:0061162)2.80707142
96establishment or maintenance of monopolar cell polarity (GO:0061339)2.80707142
97negative regulation of viral release from host cell (GO:1902187)2.79936356
98positive regulation of keratinocyte differentiation (GO:0045618)2.77618281
99focal adhesion assembly (GO:0048041)2.77090281
100cell-substrate adherens junction assembly (GO:0007045)2.77090281
101DNA unwinding involved in DNA replication (GO:0006268)2.76986741
102embryonic placenta development (GO:0001892)2.76867467
103mitochondrial DNA replication (GO:0006264)2.74394618
104protein retention in ER lumen (GO:0006621)2.74311457
105regulation of gene silencing by RNA (GO:0060966)2.72728845
106regulation of posttranscriptional gene silencing (GO:0060147)2.72728845
107regulation of gene silencing by miRNA (GO:0060964)2.72728845
108regulation of glucose import in response to insulin stimulus (GO:2001273)2.72150576
109IMP biosynthetic process (GO:0006188)2.71666844
110thymic T cell selection (GO:0045061)2.71360409
111adherens junction assembly (GO:0034333)2.69890208
112peptidyl-arginine omega-N-methylation (GO:0035247)2.69858520
113retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.68660515
114heterochromatin organization (GO:0070828)2.68630702
115maturation of 5.8S rRNA (GO:0000460)2.68429172
116intracellular estrogen receptor signaling pathway (GO:0030520)2.68143575
117intestinal cholesterol absorption (GO:0030299)2.67763091
118regulation of type I interferon-mediated signaling pathway (GO:0060338)2.67356532
119alkaloid metabolic process (GO:0009820)2.66727999
120regulation of double-strand break repair via homologous recombination (GO:0010569)2.65874064
121urea metabolic process (GO:0019627)2.65864609
122urea cycle (GO:0000050)2.65864609
123poly(A)+ mRNA export from nucleus (GO:0016973)2.65705430
124negative regulation of mRNA processing (GO:0050686)2.65051340
125tryptophan catabolic process (GO:0006569)2.64437533
126indole-containing compound catabolic process (GO:0042436)2.64437533
127indolalkylamine catabolic process (GO:0046218)2.64437533
128lysine catabolic process (GO:0006554)2.63282183
129lysine metabolic process (GO:0006553)2.63282183
130alpha-amino acid biosynthetic process (GO:1901607)2.62820955
131triglyceride homeostasis (GO:0070328)2.62183910
132acylglycerol homeostasis (GO:0055090)2.62183910
133triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.62095296
134semaphorin-plexin signaling pathway (GO:0071526)2.61799448
135pentose-phosphate shunt (GO:0006098)2.61303489
136NADH metabolic process (GO:0006734)2.61301366
137imidazole-containing compound metabolic process (GO:0052803)2.60053201
138regulation of NFAT protein import into nucleus (GO:0051532)2.59201791
139mitotic nuclear envelope disassembly (GO:0007077)2.59077212
140resolution of meiotic recombination intermediates (GO:0000712)2.58830224
141cellular response to virus (GO:0098586)2.58804296
142entrainment of circadian clock by photoperiod (GO:0043153)2.57381203
143cytolysis (GO:0019835)2.57284343
144folic acid-containing compound metabolic process (GO:0006760)2.56872417
145regulation of fatty acid beta-oxidation (GO:0031998)2.56517970
146mitotic sister chromatid segregation (GO:0000070)2.55213945
147maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.54978329
148positive regulation of histone deacetylation (GO:0031065)2.54595406
149positive thymic T cell selection (GO:0045059)2.54496477
150one-carbon metabolic process (GO:0006730)2.54296891
151histone H4 deacetylation (GO:0070933)2.53138068
152DNA duplex unwinding (GO:0032508)2.50273232
153negative regulation of mRNA metabolic process (GO:1903312)2.50092891
154regulation of translational termination (GO:0006449)2.49460850
155nitrogen cycle metabolic process (GO:0071941)2.48991310
156snRNA processing (GO:0016180)2.47461192
157activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.47312205
158positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.46138552
159regulation of ARF GTPase activity (GO:0032312)2.46127479
160glucose catabolic process (GO:0006007)2.46021689
161response to peptidoglycan (GO:0032494)2.41988947
162pinocytosis (GO:0006907)2.41611918
163positive regulation of nuclease activity (GO:0032075)2.41442512
164rRNA transcription (GO:0009303)2.41411472
165basement membrane organization (GO:0071711)2.40089914
166viral transcription (GO:0019083)2.39611954
167regulation of cholesterol metabolic process (GO:0090181)2.38407442
168negative regulation of fatty acid transport (GO:2000192)2.38247653
169apoptotic process involved in development (GO:1902742)2.38113392
170protein localization to endosome (GO:0036010)2.37789428
171cellular response to epidermal growth factor stimulus (GO:0071364)2.35196634
172ncRNA 3-end processing (GO:0043628)2.34674652
173regulation of apoptotic process involved in morphogenesis (GO:1902337)2.33904735
174histone H3-K36 demethylation (GO:0070544)2.31619057
175regulation of cholesterol biosynthetic process (GO:0045540)2.30524948
176adenine nucleotide transport (GO:0051503)2.30367872
177activation of MAPKKK activity (GO:0000185)2.29959845
178protein carboxylation (GO:0018214)2.28224055
179peptidyl-glutamic acid carboxylation (GO:0017187)2.28224055
180DNA synthesis involved in DNA repair (GO:0000731)2.27542292
181ribonucleoprotein complex biogenesis (GO:0022613)2.25801194
182histone H3 deacetylation (GO:0070932)2.25459282
183DNA geometric change (GO:0032392)2.25042617
184purine ribonucleotide transport (GO:0015868)2.24178863

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.98104844
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.58436647
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.33628143
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.19708667
5MYC_18358816_ChIP-ChIP_MESCs_Mouse2.57583585
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.52352362
7* RXR_22158963_ChIP-Seq_LIVER_Mouse2.42766336
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.40673973
9SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.34575669
10* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.25523084
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.23647028
12* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.22397310
13KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.19729154
14ELK3_25401928_ChIP-Seq_HUVEC_Human2.15163034
15RACK7_27058665_Chip-Seq_MCF-7_Human2.14622167
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.06518530
17KDM2B_26808549_Chip-Seq_SUP-B15_Human2.06068018
18TP63_17297297_ChIP-ChIP_HaCaT_Human2.05666355
19STAT3_1855785_ChIP-Seq_MESCs_Mouse2.01370425
20E2F4_17652178_ChIP-ChIP_JURKAT_Human1.98323414
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.95709768
22* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.94164853
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.92039998
24ETS1_20019798_ChIP-Seq_JURKAT_Human1.90763398
25RARG_19884340_ChIP-ChIP_MEFs_Mouse1.90757796
26P68_20966046_ChIP-Seq_HELA_Human1.89983982
27TCF7_22412390_ChIP-Seq_EML_Mouse1.84124008
28KDM2B_26808549_Chip-Seq_DND41_Human1.84119470
29CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.83573441
30E2F1_18555785_ChIP-Seq_MESCs_Mouse1.81278162
31NANOG_18555785_ChIP-Seq_MESCs_Mouse1.79047584
32* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.74967630
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71801156
34POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.70848039
35MYC_22102868_ChIP-Seq_BL_Human1.69028340
36STAT6_21828071_ChIP-Seq_BEAS2B_Human1.67315005
37* VDR_21846776_ChIP-Seq_THP-1_Human1.66879335
38EST1_17652178_ChIP-ChIP_JURKAT_Human1.66502709
39NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.65972627
40ZNF263_19887448_ChIP-Seq_K562_Human1.65123514
41KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.65119373
42KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.65119373
43KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.65119373
44MAF_26560356_Chip-Seq_TH2_Human1.64596456
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64124063
46XRN2_22483619_ChIP-Seq_HELA_Human1.63712944
47HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.63472206
48GABP_17652178_ChIP-ChIP_JURKAT_Human1.62481851
49DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.61757328
50PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.60869949
51DCP1A_22483619_ChIP-Seq_HELA_Human1.60850460
52VDR_24763502_ChIP-Seq_THP-1_Human1.59522693
53EGR1_23403033_ChIP-Seq_LIVER_Mouse1.58549478
54KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.57919624
55* GABP_19822575_ChIP-Seq_HepG2_Human1.56528312
56MAF_26560356_Chip-Seq_TH1_Human1.55292655
57CTCF_27219007_Chip-Seq_ERYTHROID_Human1.53084604
58NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.52896758
59KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.52021179
60NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.51953741
61ESR1_15608294_ChIP-ChIP_MCF-7_Human1.51501132
62LXR_22158963_ChIP-Seq_LIVER_Mouse1.50579218
63ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.50051635
64SA1_27219007_Chip-Seq_ERYTHROID_Human1.49586220
65CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.49555111
66* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.49221461
67NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.47053035
68YY1_21170310_ChIP-Seq_MESCs_Mouse1.46734337
69KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.45670466
70ELF1_20517297_ChIP-Seq_JURKAT_Human1.45568522
71SMC4_20622854_ChIP-Seq_HELA_Human1.44850029
72CREB1_15753290_ChIP-ChIP_HEK293T_Human1.44605590
73E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.43953272
74THAP11_20581084_ChIP-Seq_MESCs_Mouse1.42886489
75ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41475039
76CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.41357149
77BCOR_27268052_Chip-Seq_Bcells_Human1.39885912
78FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.38942547
79KLF4_18555785_ChIP-Seq_MESCs_Mouse1.38300644
80MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.36823809
81TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36723401
82UTX_26944678_Chip-Seq_JUKART_Human1.33822446
83TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33695484
84VDR_23849224_ChIP-Seq_CD4+_Human1.32708256
85ERG_21242973_ChIP-ChIP_JURKAT_Human1.32183755
86NCOR1_26117541_ChIP-Seq_K562_Human1.31628894
87KDM2B_26808549_Chip-Seq_K562_Human1.31258900
88BCL6_27268052_Chip-Seq_Bcells_Human1.31109355
89CREB1_26743006_Chip-Seq_LNCaP_Human1.31015322
90E2F1_21310950_ChIP-Seq_MCF-7_Human1.29391336
91POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29224716
92MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.29110415
93CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29022696
94TCF3_18692474_ChIP-Seq_MEFs_Mouse1.28982349
95E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.27907591
96CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.27877622
97EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.27251464
98KDM5A_27292631_Chip-Seq_BREAST_Human1.26725754
99EGR1_19374776_ChIP-ChIP_THP-1_Human1.26231749
100UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.26146655
101BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.25950125
102* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.23335586
103CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.22743441
104ATF3_27146783_Chip-Seq_COLON_Human1.22565874
105* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22561614
106KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.22213980
107ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.21896274
108KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20368401
109TTF2_22483619_ChIP-Seq_HELA_Human1.19932511
110TCF3_18692474_ChIP-Seq_MESCs_Mouse1.19759251
111SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19248238
112PHF8_20622854_ChIP-Seq_HELA_Human1.19158422
113KDM2B_26808549_Chip-Seq_JURKAT_Human1.19044358
114CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.18936492
115POU5F1_16518401_ChIP-PET_MESCs_Mouse1.18633404
116CIITA_25753668_ChIP-Seq_RAJI_Human1.18553511
117FOXP3_21729870_ChIP-Seq_TREG_Human1.18529602
118RUNX1_22412390_ChIP-Seq_EML_Mouse1.16193930
119* RARA_24833708_ChIP-Seq_LIVER_Mouse1.15344921
120AR_21909140_ChIP-Seq_LNCAP_Human1.14316854
121MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.13515662
122CTCF_26484167_Chip-Seq_Bcells_Mouse1.12333221
123CTCF_21964334_Chip-Seq_Bcells_Human1.11877970
124ELF1_17652178_ChIP-ChIP_JURKAT_Human1.11743507
125PU.1_20513432_ChIP-Seq_Bcells_Mouse1.10883674
126BRD4_27068464_Chip-Seq_AML-cells_Mouse1.10233387
127E2F1_20622854_ChIP-Seq_HELA_Human1.10080582
128LXR_22292898_ChIP-Seq_THP-1_Human1.09671858
129NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.09516036
130* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.09151632
131CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.09097570
132TET1_21451524_ChIP-Seq_MESCs_Mouse1.09080060
133SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08910236
134ETS1_21867929_ChIP-Seq_TH2_Mouse1.08840884
135FOXP1_21924763_ChIP-Seq_HESCs_Human1.07468256
136SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.07219066
137TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07112450
138* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.06611238
139NANOG_21062744_ChIP-ChIP_HESCs_Human1.06094803
140ZFP281_18757296_ChIP-ChIP_E14_Mouse1.06078564
141HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04982823
142SRF_21415370_ChIP-Seq_HL-1_Mouse1.04543417
143RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03967373
144OCT4_18692474_ChIP-Seq_MEFs_Mouse1.01613851
145NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.01020342
146* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.00991004
147TFEB_21752829_ChIP-Seq_HELA_Human1.00144752
148* SOX2_18555785_ChIP-Seq_MESCs_Mouse0.98002954
149SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97119090
150NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.97037159
151GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95741527
152PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95541580
153* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.95058009
154RARB_24833708_ChIP-Seq_LIVER_Mouse0.94680328
155* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94149684
156SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.92545352
157PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92350155

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.22671361
2MP0002139_abnormal_hepatobiliary_system3.95460372
3MP0005085_abnormal_gallbladder_physiolo3.93338665
4MP0005365_abnormal_bile_salt3.85876433
5MP0005360_urolithiasis3.85473697
6MP0003806_abnormal_nucleotide_metabolis3.84018000
7MP0005451_abnormal_body_composition3.37878552
8MP0004185_abnormal_adipocyte_glucose3.01012647
9MP0010094_abnormal_chromosome_stability2.78965565
10MP0004957_abnormal_blastocyst_morpholog2.65922834
11MP0003693_abnormal_embryo_hatching2.55683444
12MP0003111_abnormal_nucleus_morphology2.44492599
13MP0002877_abnormal_melanocyte_morpholog2.34305441
14MP0010234_abnormal_vibrissa_follicle2.28126529
15MP0008260_abnormal_autophagy2.22008697
16MP0009278_abnormal_bone_marrow2.21304441
17MP0005409_darkened_coat_color2.19656918
18MP0009840_abnormal_foam_cell2.14822483
19MP0008875_abnormal_xenobiotic_pharmacok2.08363374
20MP0004381_abnormal_hair_follicle2.08207160
21MP0008058_abnormal_DNA_repair2.06123140
22MP0005666_abnormal_adipose_tissue2.03791805
23MP0000678_abnormal_parathyroid_gland2.01954499
24MP0001849_ear_inflammation2.00714610
25MP0003077_abnormal_cell_cycle1.89828566
26MP0010329_abnormal_lipoprotein_level1.87218635
27MP0004858_abnormal_nervous_system1.86503735
28MP0000003_abnormal_adipose_tissue1.82206956
29MP0003303_peritoneal_inflammation1.79879674
30MP0003786_premature_aging1.75011261
31MP0003436_decreased_susceptibility_to1.73768537
32MP0010352_gastrointestinal_tract_polyps1.72021599
33MP0005375_adipose_tissue_phenotype1.70464057
34MP0001545_abnormal_hematopoietic_system1.69154342
35MP0005397_hematopoietic_system_phenotyp1.69154342
36MP0003763_abnormal_thymus_physiology1.65736939
37MP0005083_abnormal_biliary_tract1.62963051
38MP0010030_abnormal_orbit_morphology1.62490730
39MP0003191_abnormal_cellular_cholesterol1.60111035
40MP0000609_abnormal_liver_physiology1.59315612
41MP0003252_abnormal_bile_duct1.59299720
42MP0005332_abnormal_amino_acid1.59063323
43MP0003890_abnormal_embryonic-extraembry1.57961071
44MP0005266_abnormal_metabolism1.48418727
45MP0003705_abnormal_hypodermis_morpholog1.48275483
46MP0001730_embryonic_growth_arrest1.47038204
47MP0004019_abnormal_vitamin_homeostasis1.45347260
48MP0003718_maternal_effect1.43139028
49MP0001661_extended_life_span1.42645244
50MP0004233_abnormal_muscle_weight1.41174178
51MP0003656_abnormal_erythrocyte_physiolo1.37385575
52MP0002086_abnormal_extraembryonic_tissu1.37140038
53MP0004133_heterotaxia1.37122731
54MP0004264_abnormal_extraembryonic_tissu1.36593812
55MP0000858_altered_metastatic_potential1.36033005
56MP0004947_skin_inflammation1.35699237
57MP0001764_abnormal_homeostasis1.34076271
58MP0005319_abnormal_enzyme/_coenzyme1.32352006
59MP0008932_abnormal_embryonic_tissue1.31573851
60MP0001697_abnormal_embryo_size1.30978548
61MP0008995_early_reproductive_senescence1.30569789
62MP0001666_abnormal_nutrient_absorption1.30517508
63MP0000537_abnormal_urethra_morphology1.29791465
64MP0000490_abnormal_crypts_of1.29764005
65MP0001348_abnormal_lacrimal_gland1.28721400
66MP0005075_abnormal_melanosome_morpholog1.26380664
67MP0004197_abnormal_fetal_growth/weight/1.24851017
68MP0003186_abnormal_redox_activity1.24702398
69MP0001672_abnormal_embryogenesis/_devel1.22366506
70MP0005380_embryogenesis_phenotype1.22366506
71MP0002019_abnormal_tumor_incidence1.22004186
72MP0002396_abnormal_hematopoietic_system1.21490409
73MP0004808_abnormal_hematopoietic_stem1.19591372
74MP0006036_abnormal_mitochondrial_physio1.19091269
75MP0000350_abnormal_cell_proliferation1.17378697
76MP0002084_abnormal_developmental_patter1.15544763
77MP0000371_diluted_coat_color1.15521464
78MP0002269_muscular_atrophy1.14538853
79MP0000598_abnormal_liver_morphology1.13538986
80MP0002080_prenatal_lethality1.11734643
81MP0002085_abnormal_embryonic_tissue1.10005244
82MP0001293_anophthalmia1.09228368
83MP0003119_abnormal_digestive_system1.07153361
84MP0010307_abnormal_tumor_latency1.05951042
85MP0000015_abnormal_ear_pigmentation1.05921554
86MP0000703_abnormal_thymus_morphology1.05421642
87MP0000733_abnormal_muscle_development1.04534384
88MP0005171_absent_coat_pigmentation1.03312590
89MP0005076_abnormal_cell_differentiation1.03013001
90MP0009931_abnormal_skin_appearance1.01483897
91MP0003984_embryonic_growth_retardation1.01261198
92MP0005376_homeostasis/metabolism_phenot1.00266662
93MP0002332_abnormal_exercise_endurance1.00123524
94MP0003453_abnormal_keratinocyte_physiol0.99615819
95MP0002088_abnormal_embryonic_growth/wei0.98479670
96MP0002118_abnormal_lipid_homeostasis0.96090192
97MP0000747_muscle_weakness0.95710613
98MP0001216_abnormal_epidermal_layer0.95436995
99MP0003567_abnormal_fetal_cardiomyocyte0.95254811
100MP0008877_abnormal_DNA_methylation0.95173570
101MP0005174_abnormal_tail_pigmentation0.93104232
102MP0000313_abnormal_cell_death0.92815059
103MP0002132_abnormal_respiratory_system0.92483556
104MP0002398_abnormal_bone_marrow0.91146003
105MP0003566_abnormal_cell_adhesion0.90625216
106MP0002089_abnormal_postnatal_growth/wei0.90609840
107MP0000751_myopathy0.90405127
108MP0000685_abnormal_immune_system0.90160837
109MP0003136_yellow_coat_color0.90080919
110MP0005621_abnormal_cell_physiology0.89139763
111MP0003123_paternal_imprinting0.88102009
112MP0002009_preneoplasia0.86801112
113MP0005330_cardiomyopathy0.86219955
114MP0010155_abnormal_intestine_physiology0.84933952
115MP0001188_hyperpigmentation0.83328834
116MP0005058_abnormal_lysosome_morphology0.83318235
117MP0008007_abnormal_cellular_replicative0.83301864
118MP0005647_abnormal_sex_gland0.81808049
119MP0009333_abnormal_splenocyte_physiolog0.81622886
120MP0000689_abnormal_spleen_morphology0.81503758
121MP0003283_abnormal_digestive_organ0.81140989
122MP0003091_abnormal_cell_migration0.80839615
123MP0002429_abnormal_blood_cell0.80569167
124MP0009672_abnormal_birth_weight0.79208150
125MP0004510_myositis0.78810189
126MP0002111_abnormal_tail_morphology0.77903244
127MP0002060_abnormal_skin_morphology0.76159466
128MP0001145_abnormal_male_reproductive0.76130464
129MP0005220_abnormal_exocrine_pancreas0.76071938
130MP0005023_abnormal_wound_healing0.75492938
131MP0005025_abnormal_response_to0.75115274
132MP0001346_abnormal_lacrimal_gland0.74999255
133MP0005501_abnormal_skin_physiology0.74682390
134MP0000759_abnormal_skeletal_muscle0.74311238
135MP0000750_abnormal_muscle_regeneration0.74118463
136MP0002796_impaired_skin_barrier0.74065706
137MP0003195_calcinosis0.73964158
138MP0002970_abnormal_white_adipose0.73918172
139MP0002653_abnormal_ependyma_morphology0.73302796
140MP0005310_abnormal_salivary_gland0.71973729
141MP0005584_abnormal_enzyme/coenzyme_acti0.70787648
142MP0001873_stomach_inflammation0.69940448
143MP0002249_abnormal_larynx_morphology0.69386548
144MP0000716_abnormal_immune_system0.68858848
145MP0005670_abnormal_white_adipose0.68344816
146MP0000358_abnormal_cell_content/0.68215382
147MP0003172_abnormal_lysosome_physiology0.67713008
148MP0006082_CNS_inflammation0.66613345
149MP0010630_abnormal_cardiac_muscle0.66378965
150MP0000477_abnormal_intestine_morphology0.65854149
151MP0002722_abnormal_immune_system0.63849305

Predicted human phenotypes

RankGene SetZ-score
1Hypobetalipoproteinemia (HP:0003563)5.19343757
2Abnormality of monocarboxylic acid metabolism (HP:0010996)4.36896635
3Abnormality of aromatic amino acid family metabolism (HP:0004338)4.32218028
4Hypochromic microcytic anemia (HP:0004840)4.11568275
5Intrahepatic cholestasis (HP:0001406)4.07992515
6Thin bony cortex (HP:0002753)3.93355376
7Abnormality of pyrimidine metabolism (HP:0004353)3.71049780
8Rib fusion (HP:0000902)3.69425188
9Pustule (HP:0200039)3.63420912
10Poikiloderma (HP:0001029)3.30312065
11Xanthomatosis (HP:0000991)3.29249528
12Deep venous thrombosis (HP:0002625)3.26202804
13Hyperammonemia (HP:0001987)3.25828381
14Testicular atrophy (HP:0000029)3.18886641
15Hypolipoproteinemia (HP:0010981)3.14791923
16Facial hemangioma (HP:0000329)3.08515494
17Rectovaginal fistula (HP:0000143)3.04654980
18Rectal fistula (HP:0100590)3.04654980
19Hemorrhage of the eye (HP:0011885)3.04632554
20Hyperacusis (HP:0010780)3.01108781
21Squamous cell carcinoma (HP:0002860)3.00384892
22Vaginal fistula (HP:0004320)2.99013092
23Alopecia of scalp (HP:0002293)2.96260640
24Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.88538275
25Hyperlipoproteinemia (HP:0010980)2.83984836
26Selective tooth agenesis (HP:0001592)2.82879664
27Achilles tendon contracture (HP:0001771)2.82816183
28Myopathic facies (HP:0002058)2.81234187
29Abnormal hemoglobin (HP:0011902)2.80856233
30Hyperglycinemia (HP:0002154)2.79016585
31Hyperglycinuria (HP:0003108)2.76690158
32Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.73997845
33Intestinal fistula (HP:0100819)2.73571025
34Broad face (HP:0000283)2.73408654
35Basal cell carcinoma (HP:0002671)2.71195118
36Tongue fasciculations (HP:0001308)2.69940683
37Abnormality of sulfur amino acid metabolism (HP:0004339)2.69707230
38Prolonged partial thromboplastin time (HP:0003645)2.67809858
39Turricephaly (HP:0000262)2.66997656
40Progressive muscle weakness (HP:0003323)2.65224590
41Spastic diplegia (HP:0001264)2.63468058
42Hypochromic anemia (HP:0001931)2.62604022
43Abnormality of the Achilles tendon (HP:0005109)2.60513817
44Stridor (HP:0010307)2.59797141
45Abnormality of methionine metabolism (HP:0010901)2.55007711
46Ketosis (HP:0001946)2.54989373
47Ragged-red muscle fibers (HP:0003200)2.53013844
48Annular pancreas (HP:0001734)2.50329774
49Broad distal phalanx of finger (HP:0009836)2.50156360
50Pancreatic islet-cell hyperplasia (HP:0004510)2.46810139
51Progressive external ophthalmoplegia (HP:0000590)2.45987075
52Abnormality of glycine metabolism (HP:0010895)2.45605870
53Abnormality of serine family amino acid metabolism (HP:0010894)2.45605870
54Patellar aplasia (HP:0006443)2.44815070
55Absent thumb (HP:0009777)2.44202326
56Colitis (HP:0002583)2.43148236
57Distal lower limb amyotrophy (HP:0008944)2.42881367
58Muscle fibrillation (HP:0010546)2.42757638
59Abnormality of aspartate family amino acid metabolism (HP:0010899)2.41675418
60Ulnar bowing (HP:0003031)2.40576034
61Delayed CNS myelination (HP:0002188)2.38700606
62Fat malabsorption (HP:0002630)2.38068524
63Absent radius (HP:0003974)2.37660538
64Abnormality of the fingertips (HP:0001211)2.35450858
65Opisthotonus (HP:0002179)2.34393553
66Flat acetabular roof (HP:0003180)2.33889376
67Abnormality of the thoracic spine (HP:0100711)2.33621282
68Concave nail (HP:0001598)2.30568232
69Breast hypoplasia (HP:0003187)2.25959180
70Aplasia/hypoplasia of the humerus (HP:0006507)2.25589756
71Increased IgM level (HP:0003496)2.25346380
72Complement deficiency (HP:0004431)2.24093432
73Biconcave vertebral bodies (HP:0004586)2.23039895
74Abnormality of the pancreatic islet cells (HP:0006476)2.21132212
75Abnormality of endocrine pancreas physiology (HP:0012093)2.21132212
76Aplasia/Hypoplasia of the patella (HP:0006498)2.20809640
77Abnormality of glutamine family amino acid metabolism (HP:0010902)2.19456176
78Premature graying of hair (HP:0002216)2.16756376
79Oral leukoplakia (HP:0002745)2.16423518
80Vertebral compression fractures (HP:0002953)2.16408305
81Absent forearm bone (HP:0003953)2.16244671
82Aplasia involving forearm bones (HP:0009822)2.16244671
83Disproportionate tall stature (HP:0001519)2.15399589
84J-shaped sella turcica (HP:0002680)2.14712825
85Cerebral aneurysm (HP:0004944)2.13816953
86Distal upper limb amyotrophy (HP:0007149)2.12135095
87Upper limb amyotrophy (HP:0009129)2.12135095
88Rectal prolapse (HP:0002035)2.11610361
89Polycythemia (HP:0001901)2.11045555
90Hypercholesterolemia (HP:0003124)2.09991898
91Orthostatic hypotension (HP:0001278)2.09879047
92Exercise-induced myalgia (HP:0003738)2.09553308
93Short humerus (HP:0005792)2.09404590
94Abnormality of cells of the erythroid lineage (HP:0012130)2.09399919
95Easy fatigability (HP:0003388)2.09047849
96Abnormality of nucleobase metabolism (HP:0010932)2.08689900
97Abnormality of serum amino acid levels (HP:0003112)2.08357941
98Bowing of the arm (HP:0006488)2.07688908
99Bowed forearm bones (HP:0003956)2.07688908
100Seborrheic dermatitis (HP:0001051)2.06126513
101Ependymoma (HP:0002888)2.06090538
102Abnormal number of erythroid precursors (HP:0012131)2.05667165
103Malnutrition (HP:0004395)2.04943913
104Obstructive sleep apnea (HP:0002870)2.04755567
105Hypertensive crisis (HP:0100735)2.02947336
106Long palpebral fissure (HP:0000637)2.02921145
107Ketoacidosis (HP:0001993)2.02184583
108Hypertriglyceridemia (HP:0002155)2.02100425
109Microvesicular hepatic steatosis (HP:0001414)2.01360064
110Abnormality of male internal genitalia (HP:0000022)2.00519417
111Hypoglycemic coma (HP:0001325)1.99338920
112Joint stiffness (HP:0001387)1.98179113
113Steatorrhea (HP:0002570)1.97938279
114Thin ribs (HP:0000883)1.96982440
115Thoracic kyphosis (HP:0002942)1.96978675
116Trismus (HP:0000211)1.96740330
117Abnormality of complement system (HP:0005339)1.95996227
118Aplasia/Hypoplasia of the sacrum (HP:0008517)1.95284478
119Myoglobinuria (HP:0002913)1.94780399
120Abnormality of lateral ventricle (HP:0030047)1.94475721
121Villous atrophy (HP:0011473)1.93969299
122Abnormality of small intestinal villus morphology (HP:0011472)1.93969299
123Joint hemorrhage (HP:0005261)1.92889030
124Dysostosis multiplex (HP:0000943)1.92751511
125Male infertility (HP:0003251)1.92735306
126Delayed epiphyseal ossification (HP:0002663)1.91812053
127Acute hepatic failure (HP:0006554)1.91231202
128Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.91210285
129Vertebral hypoplasia (HP:0008417)1.91210285
130Albinism (HP:0001022)1.91150684
131Cervical subluxation (HP:0003308)1.89975072
132Myocardial infarction (HP:0001658)1.89848086
133Hypokinesia (HP:0002375)1.89180950
134Hyperbilirubinemia (HP:0002904)1.89093793
135Asymmetry of the thorax (HP:0001555)1.88961020
136Lower limb hyperreflexia (HP:0002395)1.88100373
137Multiple enchondromatosis (HP:0005701)1.87055185
138Abnormality of the distal phalanges of the toes (HP:0010182)1.86894637
139Lethargy (HP:0001254)1.86244080
140Abnormality of the labia minora (HP:0012880)1.85890109
141Increased connective tissue (HP:0009025)1.85660395
142Gastrointestinal inflammation (HP:0004386)1.85312755
143Reticulocytosis (HP:0001923)1.82997000
144Dysautonomia (HP:0002459)1.82025463
145Hypoalphalipoproteinemia (HP:0003233)1.81354350
146Germ cell neoplasia (HP:0100728)1.81142053
147Self-mutilation (HP:0000742)1.80715174
148Increased serum ferritin (HP:0003281)1.80648315
149Hyperparathyroidism (HP:0000843)1.80515013
150Cellulitis (HP:0100658)1.80184447
151Premature skin wrinkling (HP:0100678)1.80121320
152Mucopolysacchariduria (HP:0008155)1.79727761
153Urinary glycosaminoglycan excretion (HP:0003541)1.79727761
154Centrally nucleated skeletal muscle fibers (HP:0003687)1.79111654
155Birth length less than 3rd percentile (HP:0003561)1.78743343
156Septate vagina (HP:0001153)1.78700521
157Vertebral fusion (HP:0002948)1.77703721
158Eczematoid dermatitis (HP:0000976)1.77689751
159Bulbar palsy (HP:0001283)1.77131478
160Emphysema (HP:0002097)1.74404313
161Abnormal gallbladder physiology (HP:0012438)1.72919011
162Cholecystitis (HP:0001082)1.72919011
163Truncus arteriosus (HP:0001660)1.71486761
164Deep palmar crease (HP:0006191)1.70427719
165Metaphyseal cupping (HP:0003021)1.69738486
166Distal lower limb muscle weakness (HP:0009053)1.69156410
167Elbow flexion contracture (HP:0002987)1.68077790
168Abdominal distention (HP:0003270)1.67846334
169Hyperthyroidism (HP:0000836)1.65043936
170Flattened epiphyses (HP:0003071)1.64524090
171Cholelithiasis (HP:0001081)1.64052940
172Microretrognathia (HP:0000308)1.64036001
173Dislocated radial head (HP:0003083)1.61902116
174Atelectasis (HP:0100750)1.61358278
175Abnormality of the umbilical cord (HP:0010881)1.60504126
176Abnormal trabecular bone morphology (HP:0100671)1.59402036
177Abnormality of reticulocytes (HP:0004312)1.58095393
178Elevated alkaline phosphatase (HP:0003155)1.57190871
179Abnormality of mucopolysaccharide metabolism (HP:0011020)1.57108652
180Abnormality of polysaccharide metabolism (HP:0011012)1.57108652
181Abnormality of glycosaminoglycan metabolism (HP:0004371)1.57108652
182External ophthalmoplegia (HP:0000544)1.56448047

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK4.58459407
2SMG13.65155552
3MAP3K113.35786697
4MAP3K63.18006790
5IRAK32.97985752
6PRPF4B2.95189925
7MAPK152.92885007
8DDR22.89915068
9PINK12.66515168
10BCKDK2.49568356
11WEE12.36143634
12BUB12.26155455
13EPHA22.23887640
14CDK72.19953136
15MATK2.10381359
16MST1R1.91722262
17CDC71.91637352
18DAPK11.89049084
19MAP3K101.88279744
20PIM21.86253352
21CDK121.81373071
22NEK21.72666285
23TYRO31.68585840
24FGR1.67781774
25BMX1.64521027
26PIM11.62535593
27DYRK1B1.57439111
28CSK1.55768488
29YES11.52150164
30DYRK31.52039047
31NME21.51236213
32MAPK111.48038950
33PLK11.38839981
34TTK1.37972645
35CDK61.36478220
36RIPK11.33164984
37CHEK21.32443039
38NEK11.31227097
39RPS6KB21.28453633
40TESK21.28412003
41IRAK21.22308120
42IRAK41.22161880
43CDK41.17711238
44PDGFRA1.17371132
45PRKD21.17148319
46UHMK11.16686185
47TAOK11.15387012
48ATR1.14848003
49PDPK11.09894085
50MAP3K131.09811379
51ERN11.08758284
52MAP4K11.07800077
53FLT31.06914916
54PRKD31.06799612
55TTN1.06596763
56ACVR1B1.03094090
57AKT31.02710484
58MAP3K30.97439357
59AURKA0.95610211
60TRIB30.95235897
61SIK30.94667116
62KDR0.93217615
63SIK20.92502163
64PTK60.91292108
65LATS20.90881959
66AURKB0.90044374
67TBK10.89802149
68PKN20.88982712
69MARK20.87410085
70MAP2K20.86494009
71RPS6KC10.85647461
72RPS6KL10.85647461
73ARAF0.85186131
74EIF2AK10.84267046
75TAOK20.81120795
76MTOR0.79889748
77BRAF0.79368204
78MAP3K80.79269008
79PAK40.78987874
80RIPK40.78699826
81GSK3A0.77925421
82ZAP700.76967280
83STK100.76816308
84TLK10.75931112
85RPS6KA60.75444814
86EEF2K0.74986513
87MAP3K10.73718337
88MAP2K60.72026978
89MAPK120.71854011
90STK40.71764419
91RPS6KA20.71413544
92LRRK20.70566748
93MAPKAPK30.70357910
94CHEK10.69293551
95TNK20.68630046
96MAP3K140.65822335
97MAP2K30.65659801
98CDK20.64795195
99CAMK1D0.64331827
100ILK0.63646801
101HIPK20.62867996
102CSNK2A10.62352552
103MET0.62340216
104RPS6KA10.62129626
105PTK20.62116356
106BLK0.61654017
107PDK20.61021041
108KSR20.59845662
109PDK10.58871939
110SRPK10.58141674
111CSNK2A20.57806729
112STK160.56946183
113GRK60.56619961
114EIF2AK30.56284372
115TRPM70.54725222
116SIK10.54455426
117BRSK20.53631509
118ATM0.52308942
119STK30.52203263
120SCYL20.51986771
121FGFR40.51878134
122TESK10.51163834
123EPHB10.44157377
124PDK40.42648760
125PDK30.42648760
126PRKCI0.42316272
127LYN0.42285674
128MAPK40.41794643
129CDK80.40683964
130PAK10.40668503
131MARK30.40269274
132PASK0.39870943
133CAMKK10.39317147
134RAF10.39136355
135AKT20.38705662
136JAK30.38089478
137PLK40.36446094
138PRKAA10.36363981
139CDC42BPA0.33973672
140JAK20.33591976
141MAPK30.33376041
142CSNK1G10.32729584
143CDK10.32703627
144EGFR0.32646598
145RPS6KB10.32378871
146BTK0.31755853
147TYK20.31447375
148BRSK10.30193625
149MAP3K70.29364511

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.65646587
2Mismatch repair_Homo sapiens_hsa034303.42243364
3DNA replication_Homo sapiens_hsa030303.41664944
4Base excision repair_Homo sapiens_hsa034102.77404145
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.49522686
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.27097188
7One carbon pool by folate_Homo sapiens_hsa006702.26619538
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.19678975
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.17954757
10Acute myeloid leukemia_Homo sapiens_hsa052212.15241996
11Arginine biosynthesis_Homo sapiens_hsa002202.14949727
12Biosynthesis of amino acids_Homo sapiens_hsa012302.13481840
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.10414666
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.09533469
15Fatty acid biosynthesis_Homo sapiens_hsa000612.09324035
16Folate biosynthesis_Homo sapiens_hsa007902.03426425
17Chronic myeloid leukemia_Homo sapiens_hsa052202.01724322
18Sulfur relay system_Homo sapiens_hsa041222.00928447
19Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.96901868
20Selenocompound metabolism_Homo sapiens_hsa004501.95043073
21Non-small cell lung cancer_Homo sapiens_hsa052231.89442755
22Spliceosome_Homo sapiens_hsa030401.81382733
23VEGF signaling pathway_Homo sapiens_hsa043701.81148969
24Glycosaminoglycan degradation_Homo sapiens_hsa005311.77978844
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.75983522
26Homologous recombination_Homo sapiens_hsa034401.74306358
27Nucleotide excision repair_Homo sapiens_hsa034201.68652267
28RNA transport_Homo sapiens_hsa030131.67911943
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.63186824
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.62193318
31Ribosome_Homo sapiens_hsa030101.59886859
32B cell receptor signaling pathway_Homo sapiens_hsa046621.54101408
33Fatty acid metabolism_Homo sapiens_hsa012121.47354828
34Arginine and proline metabolism_Homo sapiens_hsa003301.45765941
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.45119023
36Central carbon metabolism in cancer_Homo sapiens_hsa052301.43795586
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.43776101
38Nitrogen metabolism_Homo sapiens_hsa009101.42352085
39Cyanoamino acid metabolism_Homo sapiens_hsa004601.42151618
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.40728093
41Tryptophan metabolism_Homo sapiens_hsa003801.40109496
42Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.39060474
43Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.38450139
44Pancreatic cancer_Homo sapiens_hsa052121.36580215
45Fatty acid degradation_Homo sapiens_hsa000711.33893520
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.33030073
47Proteasome_Homo sapiens_hsa030501.27179098
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.27050269
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.26453824
50Carbon metabolism_Homo sapiens_hsa012001.25908708
51Pyrimidine metabolism_Homo sapiens_hsa002401.20042490
52Complement and coagulation cascades_Homo sapiens_hsa046101.19827353
53Fanconi anemia pathway_Homo sapiens_hsa034601.16441973
54Peroxisome_Homo sapiens_hsa041461.14796532
55Insulin signaling pathway_Homo sapiens_hsa049101.13653863
56Propanoate metabolism_Homo sapiens_hsa006401.12798268
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.09060284
58Thyroid cancer_Homo sapiens_hsa052161.07739720
59Pyruvate metabolism_Homo sapiens_hsa006201.07523944
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.06780498
61Neurotrophin signaling pathway_Homo sapiens_hsa047221.04789532
62Cell cycle_Homo sapiens_hsa041101.04178672
63Hepatitis C_Homo sapiens_hsa051601.03709597
64Endometrial cancer_Homo sapiens_hsa052131.02416786
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01510518
66Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.01419973
67RNA polymerase_Homo sapiens_hsa030201.01178991
68mRNA surveillance pathway_Homo sapiens_hsa030151.00844009
69Lysine degradation_Homo sapiens_hsa003101.00255370
70Longevity regulating pathway - mammal_Homo sapiens_hsa042110.98433393
71Toll-like receptor signaling pathway_Homo sapiens_hsa046200.98366099
72Glutathione metabolism_Homo sapiens_hsa004800.97351500
73Prion diseases_Homo sapiens_hsa050200.97245884
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.96956642
75Pentose phosphate pathway_Homo sapiens_hsa000300.96080277
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94634883
77Apoptosis_Homo sapiens_hsa042100.94576433
78HTLV-I infection_Homo sapiens_hsa051660.93727489
79RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.93074771
80p53 signaling pathway_Homo sapiens_hsa041150.92049553
81Glioma_Homo sapiens_hsa052140.88887151
82Influenza A_Homo sapiens_hsa051640.88832122
83Small cell lung cancer_Homo sapiens_hsa052220.88798911
84beta-Alanine metabolism_Homo sapiens_hsa004100.88616277
85Chemical carcinogenesis_Homo sapiens_hsa052040.88484236
86Hepatitis B_Homo sapiens_hsa051610.88246576
87Insulin resistance_Homo sapiens_hsa049310.88110472
88Fat digestion and absorption_Homo sapiens_hsa049750.87750030
89Fructose and mannose metabolism_Homo sapiens_hsa000510.87206953
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87099532
91Herpes simplex infection_Homo sapiens_hsa051680.87009216
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85865357
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85437701
94Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85296817
95Osteoclast differentiation_Homo sapiens_hsa043800.85113473
96AMPK signaling pathway_Homo sapiens_hsa041520.83759658
97Inositol phosphate metabolism_Homo sapiens_hsa005620.81230199
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.80599635
99Prostate cancer_Homo sapiens_hsa052150.80351929
100Vitamin B6 metabolism_Homo sapiens_hsa007500.79434680
101Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78902710
102PPAR signaling pathway_Homo sapiens_hsa033200.78630084
103NF-kappa B signaling pathway_Homo sapiens_hsa040640.77906184
104Epstein-Barr virus infection_Homo sapiens_hsa051690.76882567
105N-Glycan biosynthesis_Homo sapiens_hsa005100.76412857
106AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76336924
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76216747
108Caffeine metabolism_Homo sapiens_hsa002320.76045457
109Butanoate metabolism_Homo sapiens_hsa006500.76026498
110TNF signaling pathway_Homo sapiens_hsa046680.74644137
111Staphylococcus aureus infection_Homo sapiens_hsa051500.74588344
112Toxoplasmosis_Homo sapiens_hsa051450.73006596
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72998678
114Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72681930
115ErbB signaling pathway_Homo sapiens_hsa040120.72219889
116Retinol metabolism_Homo sapiens_hsa008300.71651940
117Renal cell carcinoma_Homo sapiens_hsa052110.70426681
118Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70240920
119T cell receptor signaling pathway_Homo sapiens_hsa046600.70034550
120Histidine metabolism_Homo sapiens_hsa003400.69569556
121Phenylalanine metabolism_Homo sapiens_hsa003600.67918648
122Non-homologous end-joining_Homo sapiens_hsa034500.66446950
123Choline metabolism in cancer_Homo sapiens_hsa052310.66035080
124Prolactin signaling pathway_Homo sapiens_hsa049170.64959846
125Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64225667
126Lysosome_Homo sapiens_hsa041420.63534733
127Leishmaniasis_Homo sapiens_hsa051400.62876948
128ABC transporters_Homo sapiens_hsa020100.62874417
129Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62685720
130Notch signaling pathway_Homo sapiens_hsa043300.62633387
131GnRH signaling pathway_Homo sapiens_hsa049120.61249657
132Starch and sucrose metabolism_Homo sapiens_hsa005000.61018406
133Systemic lupus erythematosus_Homo sapiens_hsa053220.61001790
134Steroid hormone biosynthesis_Homo sapiens_hsa001400.60948744
135Colorectal cancer_Homo sapiens_hsa052100.60905015
136Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59315957
137Glycerophospholipid metabolism_Homo sapiens_hsa005640.58409542
138Galactose metabolism_Homo sapiens_hsa000520.56917244
139Fatty acid elongation_Homo sapiens_hsa000620.56236030
140Tyrosine metabolism_Homo sapiens_hsa003500.53624050
141Metabolic pathways_Homo sapiens_hsa011000.50296934
142Phospholipase D signaling pathway_Homo sapiens_hsa040720.50186566
143Shigellosis_Homo sapiens_hsa051310.48933570
144HIF-1 signaling pathway_Homo sapiens_hsa040660.47523568
145RNA degradation_Homo sapiens_hsa030180.46660325
146Measles_Homo sapiens_hsa051620.45485023
147Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.45320312
148Endocytosis_Homo sapiens_hsa041440.45231743
149Glycerolipid metabolism_Homo sapiens_hsa005610.44655522
150Basal transcription factors_Homo sapiens_hsa030220.44554503
151Bile secretion_Homo sapiens_hsa049760.43630049
152Sphingolipid signaling pathway_Homo sapiens_hsa040710.43000305
153MicroRNAs in cancer_Homo sapiens_hsa052060.42935830
154Glucagon signaling pathway_Homo sapiens_hsa049220.42102334
155Bladder cancer_Homo sapiens_hsa052190.41973619
156mTOR signaling pathway_Homo sapiens_hsa041500.39894806
157Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38895922
158Legionellosis_Homo sapiens_hsa051340.38749414
159Steroid biosynthesis_Homo sapiens_hsa001000.38593916
160Vitamin digestion and absorption_Homo sapiens_hsa049770.37571835
161Purine metabolism_Homo sapiens_hsa002300.31079959
162Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.29914641
163Primary immunodeficiency_Homo sapiens_hsa053400.29111160
164Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27502534
165Viral carcinogenesis_Homo sapiens_hsa052030.25838617
166Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.25595997
167Hippo signaling pathway_Homo sapiens_hsa043900.23733072

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