DTX3L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: DTX3L functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.32054665
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.32054665
3antigen processing and presentation of endogenous antigen (GO:0019883)5.83829520
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.45493462
5positive regulation of interferon-alpha production (GO:0032727)4.85177938
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.74119428
7negative regulation of cell killing (GO:0031342)4.74119428
8response to type I interferon (GO:0034340)4.68279948
9cellular response to type I interferon (GO:0071357)4.64782997
10type I interferon signaling pathway (GO:0060337)4.64782997
11regulation of interferon-alpha production (GO:0032647)4.59720891
12positive regulation of gamma-delta T cell activation (GO:0046645)4.50765365
13positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.12035073
14negative regulation of interleukin-12 production (GO:0032695)3.84134370
15detection of other organism (GO:0098543)3.80204767
16response to interferon-alpha (GO:0035455)3.77842904
17detection of molecule of bacterial origin (GO:0032490)3.73794243
18regulation of RIG-I signaling pathway (GO:0039535)3.68366420
19immunoglobulin mediated immune response (GO:0016064)3.65058787
20positive regulation by organism of defense response of other organism involved in symbiotic interact3.61389508
21modulation by symbiont of host immune response (GO:0052553)3.61389508
22positive regulation by symbiont of host defense response (GO:0052509)3.61389508
23modulation by symbiont of host defense response (GO:0052031)3.61389508
24modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.61389508
25modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.61389508
26detection of bacterium (GO:0016045)3.59147526
27interferon-gamma-mediated signaling pathway (GO:0060333)3.53007994
28detection of external biotic stimulus (GO:0098581)3.51489415
29positive regulation of natural killer cell differentiation (GO:0032825)3.50644918
30negative regulation of viral genome replication (GO:0045071)3.48618997
31positive regulation of interferon-beta production (GO:0032728)3.47502009
32regulation of T cell tolerance induction (GO:0002664)3.43226097
33regulation of interferon-beta biosynthetic process (GO:0045357)3.42275387
34response to interferon-beta (GO:0035456)3.41253412
35regulation of interleukin-12 biosynthetic process (GO:0045075)3.36669954
36cellular response to interferon-beta (GO:0035458)3.35704068
37positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.30835282
38regulation of gamma-delta T cell differentiation (GO:0045586)3.29546470
39T cell migration (GO:0072678)3.29329554
40neutrophil activation involved in immune response (GO:0002283)3.28197844
41regulation of gamma-delta T cell activation (GO:0046643)3.26057283
42positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.26016710
43negative regulation of T cell mediated immunity (GO:0002710)3.22207184
44production of molecular mediator involved in inflammatory response (GO:0002532)3.20791253
45positive regulation of antigen processing and presentation (GO:0002579)3.20745222
46regulation of type I interferon-mediated signaling pathway (GO:0060338)3.19710546
47cellular extravasation (GO:0045123)3.19213060
48response to peptidoglycan (GO:0032494)3.19112653
49defense response to protozoan (GO:0042832)3.18042071
50regulation of tolerance induction (GO:0002643)3.17930656
51regulation of regulatory T cell differentiation (GO:0045589)3.16585557
52response to interleukin-15 (GO:0070672)3.14560140
53response to host (GO:0075136)3.11674493
54response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.11674493
55cellular response to interferon-alpha (GO:0035457)3.11330811
56negative regulation of lymphocyte mediated immunity (GO:0002707)3.11000092
57cellular response to virus (GO:0098586)3.10034269
58microglial cell activation (GO:0001774)3.08610865
59regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.07727539
60cellular response to exogenous dsRNA (GO:0071360)3.07599293
61germinal center formation (GO:0002467)3.06876409
62positive regulation of humoral immune response (GO:0002922)3.04579298
63positive regulation of type 2 immune response (GO:0002830)3.03305789
64regulation of B cell receptor signaling pathway (GO:0050855)3.02572788
65NIK/NF-kappaB signaling (GO:0038061)3.01697453
66positive regulation of B cell differentiation (GO:0045579)3.01243553
67antigen processing and presentation via MHC class Ib (GO:0002475)3.00568437
68detection of biotic stimulus (GO:0009595)3.00211341
69JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.00006897
70cellular response to interleukin-15 (GO:0071350)2.99440687
71macrophage activation (GO:0042116)2.98834756
72T-helper 1 type immune response (GO:0042088)2.98487459
73positive regulation of tolerance induction (GO:0002645)2.96641810
74B cell mediated immunity (GO:0019724)2.96163495
75regulation of response to interferon-gamma (GO:0060330)2.95859287
76response to protozoan (GO:0001562)2.94918233
77myeloid dendritic cell activation (GO:0001773)2.94444774
78regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.94311724
79regulation of alpha-beta T cell proliferation (GO:0046640)2.91525884
80interferon-gamma secretion (GO:0072643)2.91049234
81regulation of T cell mediated cytotoxicity (GO:0001914)2.90566564
82positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.85321380
83positive regulation of toll-like receptor signaling pathway (GO:0034123)2.84232646
84negative T cell selection (GO:0043383)2.84179124
85negative thymic T cell selection (GO:0045060)2.82693480
86myeloid dendritic cell differentiation (GO:0043011)2.82358147
87regulation of natural killer cell differentiation (GO:0032823)2.81719019
88interferon-gamma production (GO:0032609)2.81707186
89negative regulation of leukocyte mediated immunity (GO:0002704)2.80879821
90regulation of antigen processing and presentation (GO:0002577)2.80523366
91positive regulation of T cell mediated cytotoxicity (GO:0001916)2.80332414
92regulation of T-helper 1 cell differentiation (GO:0045625)2.80219375
93regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.79032009
94negative regulation of myeloid cell apoptotic process (GO:0033033)2.78874677
95positive regulation of interleukin-12 production (GO:0032735)2.78314015
96B cell receptor signaling pathway (GO:0050853)2.78305852
97cellular response to interferon-gamma (GO:0071346)2.77510293
98natural killer cell mediated cytotoxicity (GO:0042267)2.76047365
99natural killer cell mediated immunity (GO:0002228)2.76047365
100lymphocyte chemotaxis (GO:0048247)2.75516061
101respiratory burst (GO:0045730)2.74210305
102defense response to virus (GO:0051607)2.74130565
103regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.73626247
104regulation of type 2 immune response (GO:0002828)2.73343970
105positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.72162188
106neutrophil activation (GO:0042119)2.71960220
107positive regulation of alpha-beta T cell proliferation (GO:0046641)2.71073930
108response to host immune response (GO:0052572)2.70060810
109response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.70060810
110lipopolysaccharide-mediated signaling pathway (GO:0031663)2.68935349
111negative regulation of innate immune response (GO:0045824)2.68784947
112regulation of B cell differentiation (GO:0045577)2.68564300
113regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.68468266
114regulation of hypersensitivity (GO:0002883)2.68467450
115negative regulation of cytokine production involved in immune response (GO:0002719)2.67535187
116macrophage activation involved in immune response (GO:0002281)2.66510427
117cellular response to zinc ion (GO:0071294)2.66068776
118granulocyte activation (GO:0036230)2.65983015
119regulation of interferon-beta production (GO:0032648)2.65095254
120positive regulation of response to biotic stimulus (GO:0002833)2.64349249
121response to muramyl dipeptide (GO:0032495)2.64233348
122natural killer cell activation (GO:0030101)2.62949254
123regulation of dendritic cell antigen processing and presentation (GO:0002604)2.61091814
124positive regulation of defense response to virus by host (GO:0002230)2.58545806
125positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.57585443
126regulation of activation of Janus kinase activity (GO:0010533)2.56818971
127positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.56021274
128response to interferon-gamma (GO:0034341)2.55566949
129positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.52869180
130Arp2/3 complex-mediated actin nucleation (GO:0034314)2.52196652
131myeloid cell activation involved in immune response (GO:0002275)2.49453571
132regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.49344607
133leukocyte aggregation (GO:0070486)2.47387436
134cytokine secretion (GO:0050663)2.46018464
135positive regulation of B cell mediated immunity (GO:0002714)2.45802673
136positive regulation of immunoglobulin mediated immune response (GO:0002891)2.45802673
137positive regulation of cytokine-mediated signaling pathway (GO:0001961)2.44568813
138response to host defenses (GO:0052200)2.44156240

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.21943016
2* IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.19822947
3* IRF8_21731497_ChIP-ChIP_J774_Mouse5.04810111
4* IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.66278996
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.53762953
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.81148842
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.59632723
8* IRF8_27001747_Chip-Seq_BMDM_Mouse3.23281070
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.16871033
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.98746506
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.95541103
12EGR1_23403033_ChIP-Seq_LIVER_Mouse2.89568818
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.86767764
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.85801294
15* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.83294567
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.71040755
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.51101663
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.42955515
19RXR_22158963_ChIP-Seq_LIVER_Mouse2.33725447
20E2F7_22180533_ChIP-Seq_HELA_Human2.22830844
21GATA1_22025678_ChIP-Seq_K562_Human2.22765302
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.21237025
23SCL_19346495_ChIP-Seq_HPC-7_Human2.19931772
24PPARA_22158963_ChIP-Seq_LIVER_Mouse2.19500866
25MYB_26560356_Chip-Seq_TH2_Human2.11114630
26STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.08048115
27RUNX_20019798_ChIP-Seq_JUKART_Human2.02511779
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.01286138
29Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.01143294
30* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.91783160
31MAF_26560356_Chip-Seq_TH1_Human1.91156857
32CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.90816753
33MYB_26560356_Chip-Seq_TH1_Human1.89898730
34SPI1_23547873_ChIP-Seq_NB4_Human1.87606502
35LXR_22158963_ChIP-Seq_LIVER_Mouse1.86349726
36RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.84699533
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.80032398
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.78994961
39NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.70917631
40NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.67234075
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.60902147
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.57335592
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.53158220
44PU_27001747_Chip-Seq_BMDM_Mouse1.48767384
45VDR_24763502_ChIP-Seq_THP-1_Human1.48502613
46VDR_21846776_ChIP-Seq_THP-1_Human1.42272490
47CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.42056823
48UTX_26944678_Chip-Seq_JUKART_Human1.41025777
49FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.40417806
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.38967764
51MYC_22102868_ChIP-Seq_BL_Human1.37431703
52GATA2_22383799_ChIP-Seq_G1ME_Mouse1.32533248
53GATA3_27048872_Chip-Seq_THYMUS_Human1.28263637
54CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28239377
55PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.27244526
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.26778494
57MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.26424329
58PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23434482
59CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20727592
60LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.20664731
61GATA3_26560356_Chip-Seq_TH2_Human1.18660606
62LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.16775625
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16177985
64BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.14539762
65E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.13487190
66SPI1_23127762_ChIP-Seq_K562_Human1.13417211
67GATA2_21666600_ChIP-Seq_HMVEC_Human1.10737832
68MAF_26560356_Chip-Seq_TH2_Human1.10043007
69GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06671190
70GATA1_19941826_ChIP-Seq_K562_Human1.05714828
71* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03661363
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.02994669
73VDR_24787735_ChIP-Seq_THP-1_Human1.01913453
74* TCF7_22412390_ChIP-Seq_EML_Mouse1.01876423
75PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00789111
76TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.00202133
77FOXO3_23340844_ChIP-Seq_DLD1_Human0.98869159
78GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98751470
79CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98449279
80TP63_17297297_ChIP-ChIP_HaCaT_Human0.97926266
81CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.95722122
82ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94651815
83GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94590970
84CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94086526
85BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93359194
86KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91812438
87HOXB4_20404135_ChIP-ChIP_EML_Mouse0.91338319
88VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.90684968
89* SOX2_20726797_ChIP-Seq_SW620_Human0.90305146
90GATA1_19941827_ChIP-Seq_MEL_Mouse0.89439611
91CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.89009881
92PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88644494
93SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87295382
94TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.87101739
95SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86358664
96GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85020492
97STAT6_21828071_ChIP-Seq_BEAS2B_Human0.84728403
98FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.83784052
99JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82765797
100EGR1_19032775_ChIP-ChIP_M12_Human0.82514397
101JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81856364
102SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.81735424
103SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.81735424
104PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80778546
105VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.80603279
106SMRT_27268052_Chip-Seq_Bcells_Human0.78521085
107KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.78141622
108SMAD_19615063_ChIP-ChIP_OVARY_Human0.77486479
109PPAR_26484153_Chip-Seq_NCI-H1993_Human0.77264460
110SOX2_27498859_Chip-Seq_STOMACH_Mouse0.76110254
111FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.75886671
112RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.75162809
113NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.73700203
114PU.1_20513432_ChIP-Seq_Bcells_Mouse0.72929927
115ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.72753753
116HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.67789013
117GATA2_19941826_ChIP-Seq_K562_Human0.67557736
118ELK3_25401928_ChIP-Seq_HUVEC_Human0.62549166
119NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.61259803
120TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.60655916
121TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.57899167

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.35619235
2MP0009785_altered_susceptibility_to3.50276330
3MP0000685_abnormal_immune_system3.06825034
4MP0005671_abnormal_response_to3.01591326
5MP0003436_decreased_susceptibility_to2.97408314
6MP0003724_increased_susceptibility_to2.80346760
7MP0005387_immune_system_phenotype2.76169009
8MP0001790_abnormal_immune_system2.76169009
9MP0005025_abnormal_response_to2.71652364
10MP0002148_abnormal_hypersensitivity_rea2.68441909
11MP0001800_abnormal_humoral_immune2.62615443
12MP0005000_abnormal_immune_tolerance2.60860883
13MP0002419_abnormal_innate_immunity2.43577159
14MP0002452_abnormal_antigen_presenting2.40121657
15MP0002166_altered_tumor_susceptibility2.39223204
16MP0002723_abnormal_immune_serum2.36397185
17MP0005360_urolithiasis2.33139815
18MP0002139_abnormal_hepatobiliary_system2.27525242
19MP0006082_CNS_inflammation2.22494499
20MP0001819_abnormal_immune_cell2.16117287
21MP0003763_abnormal_thymus_physiology2.14315776
22MP0002420_abnormal_adaptive_immunity2.14265833
23MP0002006_tumorigenesis2.07315927
24MP0005464_abnormal_platelet_physiology2.01230686
25MP0010155_abnormal_intestine_physiology1.96379498
26MP0003303_peritoneal_inflammation1.86235335
27MP0002398_abnormal_bone_marrow1.81044488
28MP0003191_abnormal_cellular_cholesterol1.80982313
29MP0004947_skin_inflammation1.79678826
30MP0002138_abnormal_hepatobiliary_system1.79125868
31MP0001845_abnormal_inflammatory_respons1.78252246
32MP0000716_abnormal_immune_system1.76624198
33MP0004510_myositis1.75065291
34MP0001853_heart_inflammation1.75001780
35MP0009840_abnormal_foam_cell1.74969657
36MP0005085_abnormal_gallbladder_physiolo1.72686869
37MP0008469_abnormal_protein_level1.71688119
38MP0009764_decreased_sensitivity_to1.68822627
39MP0002405_respiratory_system_inflammati1.68571334
40MP0003300_gastrointestinal_ulcer1.65247876
41MP0009333_abnormal_splenocyte_physiolog1.63519428
42MP0005365_abnormal_bile_salt1.62248463
43MP0005451_abnormal_body_composition1.58336250
44MP0000689_abnormal_spleen_morphology1.55160016
45MP0002396_abnormal_hematopoietic_system1.51531248
46MP0001533_abnormal_skeleton_physiology1.49411292
47MP0001873_stomach_inflammation1.49191254
48MP0002722_abnormal_immune_system1.46529589
49MP0002429_abnormal_blood_cell1.45723304
50MP0001545_abnormal_hematopoietic_system1.44203188
51MP0005397_hematopoietic_system_phenotyp1.44203188
52MP0003252_abnormal_bile_duct1.38562819
53MP0003183_abnormal_peptide_metabolism1.31006577
54MP0005164_abnormal_response_to1.29308839
55MP0004883_abnormal_blood_vessel1.24539072
56MP0008875_abnormal_xenobiotic_pharmacok1.24130526
57MP0002254_reproductive_system_inflammat1.22110956
58MP0009763_increased_sensitivity_to1.21916368
59MP0004808_abnormal_hematopoietic_stem1.21414213
60MP0003448_altered_tumor_morphology1.20280376
61MP0005058_abnormal_lysosome_morphology1.19450247
62MP0000609_abnormal_liver_physiology1.18028997
63MP0005310_abnormal_salivary_gland1.17042377
64MP0003045_fibrosis1.16251019
65MP0000858_altered_metastatic_potential1.10077977
66MP0003186_abnormal_redox_activity1.09319060
67MP0010329_abnormal_lipoprotein_level1.09313954
68MP0000604_amyloidosis1.09290821
69MP0004782_abnormal_surfactant_physiolog1.09118451
70MP0008260_abnormal_autophagy1.08284835
71MP0009278_abnormal_bone_marrow1.07904757
72MP0003195_calcinosis1.05970735
73MP0000703_abnormal_thymus_morphology1.03757570
74MP0000343_altered_response_to1.03722983
75MP0003866_abnormal_defecation1.00487119
76MP0003828_pulmonary_edema1.00028968
77MP0006054_spinal_hemorrhage0.99501182
78MP0002998_abnormal_bone_remodeling0.95766896
79MP0005075_abnormal_melanosome_morpholog0.95627691
80MP0003690_abnormal_glial_cell0.93977744
81MP0000490_abnormal_crypts_of0.93765208
82MP0003091_abnormal_cell_migration0.93417368
83MP0002877_abnormal_melanocyte_morpholog0.93101982
84MP0005319_abnormal_enzyme/_coenzyme0.91722156
85MP0000465_gastrointestinal_hemorrhage0.91530720
86MP0008004_abnormal_stomach_pH0.91147542
87MP0005174_abnormal_tail_pigmentation0.90279454
88MP0002332_abnormal_exercise_endurance0.89683251
89MP0002933_joint_inflammation0.88115063
90MP0003075_altered_response_to0.83731551
91MP0003172_abnormal_lysosome_physiology0.83387626
92MP0000598_abnormal_liver_morphology0.80717705
93MP0004381_abnormal_hair_follicle0.80278877
94MP0001663_abnormal_digestive_system0.79987651
95MP0009765_abnormal_xenobiotic_induced0.79752238
96MP0001666_abnormal_nutrient_absorption0.78532410
97MP0005083_abnormal_biliary_tract0.77620224
98MP0005390_skeleton_phenotype0.77417781
99MP0005166_decreased_susceptibility_to0.77390820
100MP0001764_abnormal_homeostasis0.76926802
101MP0010307_abnormal_tumor_latency0.76112854
102MP0002277_abnormal_respiratory_mucosa0.75076305
103MP0003656_abnormal_erythrocyte_physiolo0.72517130
104MP0003806_abnormal_nucleotide_metabolis0.72291100
105MP0000249_abnormal_blood_vessel0.72066677
106MP0002132_abnormal_respiratory_system0.71884233
107MP0003453_abnormal_keratinocyte_physiol0.71493671
108MP0005584_abnormal_enzyme/coenzyme_acti0.71273890
109MP0002136_abnormal_kidney_physiology0.70971218
110MP0000371_diluted_coat_color0.70410659
111MP0009697_abnormal_copulation0.69750941
112MP0005408_hypopigmentation0.69591536
113MP0010352_gastrointestinal_tract_polyps0.69190241
114MP0002019_abnormal_tumor_incidence0.68676481
115MP0003795_abnormal_bone_structure0.68594089
116MP0010234_abnormal_vibrissa_follicle0.68014595
117MP0009643_abnormal_urine_homeostasis0.67317267
118MP0005023_abnormal_wound_healing0.66003369
119MP0001348_abnormal_lacrimal_gland0.64885170
120MP0000569_abnormal_digit_pigmentation0.64701556
121MP0001851_eye_inflammation0.63151921
122MP0002693_abnormal_pancreas_physiology0.61564702
123MP0005167_abnormal_blood-brain_barrier0.61479616

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.78705602
2Recurrent abscess formation (HP:0002722)4.59385430
3Recurrent bacterial skin infections (HP:0005406)4.42430161
4Elevated erythrocyte sedimentation rate (HP:0003565)4.36685101
5Autoimmune thrombocytopenia (HP:0001973)4.17084465
6Chronic otitis media (HP:0000389)4.13992735
7Recurrent gram-negative bacterial infections (HP:0005420)4.11518281
8Myositis (HP:0100614)3.92490414
9Recurrent fungal infections (HP:0002841)3.80756085
10Recurrent viral infections (HP:0004429)3.78792454
11Mediastinal lymphadenopathy (HP:0100721)3.43929447
12Vasculitis (HP:0002633)3.39311871
13Recurrent skin infections (HP:0001581)3.38586584
14Orchitis (HP:0100796)3.34522326
15Gingival bleeding (HP:0000225)3.32114631
16Joint hemorrhage (HP:0005261)3.31123599
17Recurrent bronchitis (HP:0002837)3.21709845
18Abnormality of macrophages (HP:0004311)3.14761337
19Recurrent cutaneous fungal infections (HP:0011370)3.13765621
20Chronic mucocutaneous candidiasis (HP:0002728)3.13765621
21Systemic lupus erythematosus (HP:0002725)3.12358671
22Abnormality of T cell number (HP:0011839)3.11643717
23Nasal polyposis (HP:0100582)3.10453170
24Periodontitis (HP:0000704)3.09861493
25Retrobulbar optic neuritis (HP:0100654)3.08347237
26Optic neuritis (HP:0100653)3.08347237
27Increased IgM level (HP:0003496)3.07899612
28Abnormal delayed hypersensitivity skin test (HP:0002963)3.02999454
29Spontaneous hematomas (HP:0007420)3.00409217
30Abnormality of glycolipid metabolism (HP:0010969)2.98880708
31Abnormality of liposaccharide metabolism (HP:0010968)2.98880708
32Abnormality of glycosphingolipid metabolism (HP:0004343)2.98880708
33T lymphocytopenia (HP:0005403)2.95693721
34Meningitis (HP:0001287)2.94108146
35Abnormality of the nasal mucosa (HP:0000433)2.87732088
36Pustule (HP:0200039)2.86967459
37Gastrointestinal infarctions (HP:0005244)2.86775510
38Abnormality of T cells (HP:0002843)2.84854995
39Thrombocytosis (HP:0001894)2.79043108
40Gingivitis (HP:0000230)2.77800052
41Chest pain (HP:0100749)2.75542393
42Epistaxis (HP:0000421)2.75261719
43Autoimmune hemolytic anemia (HP:0001890)2.73806480
44Abnormality of T cell physiology (HP:0011840)2.72909104
45Hypergammaglobulinemia (HP:0010702)2.72033670
46Prolonged partial thromboplastin time (HP:0003645)2.69730641
47Myocardial infarction (HP:0001658)2.67863156
48Vacuolated lymphocytes (HP:0001922)2.63011891
49Eosinophilia (HP:0001880)2.62161641
50Basal ganglia calcification (HP:0002135)2.61361263
51IgM deficiency (HP:0002850)2.59338060
52Hemoptysis (HP:0002105)2.57797902
53Stomatitis (HP:0010280)2.56431711
54Cellulitis (HP:0100658)2.56127294
55Gangrene (HP:0100758)2.54482219
56Arterial thrombosis (HP:0004420)2.53128973
57Chronic diarrhea (HP:0002028)2.52395684
58Pulmonary infiltrates (HP:0002113)2.52334470
59Petechiae (HP:0000967)2.51287167
60Leukocytosis (HP:0001974)2.48937998
61Agammaglobulinemia (HP:0004432)2.48215525
62Inflammation of the large intestine (HP:0002037)2.47668596
63Prolonged bleeding time (HP:0003010)2.47283327
64Loss of speech (HP:0002371)2.46735816
65Colitis (HP:0002583)2.45873290
66Chronic obstructive pulmonary disease (HP:0006510)2.44555541
67Obstructive lung disease (HP:0006536)2.44555541
68Abnormality of monocarboxylic acid metabolism (HP:0010996)2.43514260
69Granulocytopenia (HP:0001913)2.43197253
70Peritonitis (HP:0002586)2.42187632
71Abnormality of the pleura (HP:0002103)2.42076014
72Abnormality of the common coagulation pathway (HP:0010990)2.41569773
73Encephalitis (HP:0002383)2.41358901
74Joint swelling (HP:0001386)2.40754967
75Complement deficiency (HP:0004431)2.38809330
76Interstitial pulmonary disease (HP:0006530)2.38641736
77Gastrointestinal inflammation (HP:0004386)2.36181348
78Cheilitis (HP:0100825)2.35505442
79Abnormality of the prostate (HP:0008775)2.33508030
80Panhypogammaglobulinemia (HP:0003139)2.33313721
81Keratoconjunctivitis sicca (HP:0001097)2.31611062
82Intrahepatic cholestasis (HP:0001406)2.31160265
83Increased IgE level (HP:0003212)2.30566076
84IgG deficiency (HP:0004315)2.30421684
85Abnormality of eosinophils (HP:0001879)2.28904263
86Deep venous thrombosis (HP:0002625)2.26855980
87Malnutrition (HP:0004395)2.26204593
88Lymphopenia (HP:0001888)2.24604060
89Abnormality of cells of the lymphoid lineage (HP:0012140)2.23508176
90Increased cerebral lipofuscin (HP:0011813)2.21836109
91Pulmonary embolism (HP:0002204)2.20962856
92Dysostosis multiplex (HP:0000943)2.19680067
93Hematochezia (HP:0002573)2.19491563
94Abnormal platelet volume (HP:0011876)2.19177533
95Osteomyelitis (HP:0002754)2.19123164
96Chronic sinusitis (HP:0011109)2.18438521
97Anorexia (HP:0002039)2.17665543
98Glomerulonephritis (HP:0000099)2.17657427
99Episodic fever (HP:0001954)2.17227370
100IgA deficiency (HP:0002720)2.15299126
101Purpura (HP:0000979)2.14753278
102Keratoconjunctivitis (HP:0001096)2.14391323
103Combined immunodeficiency (HP:0005387)2.13068488
104Urticaria (HP:0001025)2.12706359
105Abnormality of the pericardium (HP:0001697)2.11691753
106Severe combined immunodeficiency (HP:0004430)2.11426319
107Thyroiditis (HP:0100646)2.11229882
108Thrombophlebitis (HP:0004418)2.11225857
109Abnormality of the endocardium (HP:0004306)2.11058664
110Abnormality of aromatic amino acid family metabolism (HP:0004338)2.10279820
111Amyloidosis (HP:0011034)2.10166778
112Xanthomatosis (HP:0000991)2.09658569
113Hypobetalipoproteinemia (HP:0003563)2.08574712
114Menorrhagia (HP:0000132)2.08458363
115Abnormality of glutamine family amino acid metabolism (HP:0010902)2.06458859
116Esophageal varix (HP:0002040)2.05948634
117Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.05821243
118Gastrointestinal stroma tumor (HP:0100723)2.03128452
119Increased serum ferritin (HP:0003281)1.99475538
120Abnormality of mucopolysaccharide metabolism (HP:0011020)1.99387520
121Abnormality of polysaccharide metabolism (HP:0011012)1.99387520
122Abnormality of glycosaminoglycan metabolism (HP:0004371)1.99387520
123Glomerulopathy (HP:0100820)1.98585428
124Neoplasm of the tracheobronchial system (HP:0100552)1.96082948
125Abnormality of iron homeostasis (HP:0011031)1.96007271
126Alveolar cell carcinoma (HP:0006519)1.94744518
127Mucopolysacchariduria (HP:0008155)1.93178911
128Urinary glycosaminoglycan excretion (HP:0003541)1.93178911
129Acne (HP:0001061)1.93041072

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TYK23.87700488
2MAP3K143.78278173
3MAP4K13.44710251
4JAK33.27264109
5IKBKE3.20582896
6TBK13.03519741
7TXK2.95490218
8FGFR42.90078439
9KIT2.69145513
10IRAK42.66092407
11JAK12.54551019
12BLK2.05861607
13IRAK32.05738622
14ERN12.03396003
15IKBKB2.01912318
16FGFR31.88521250
17TAOK31.84555234
18PRPF4B1.77925479
19ZAP701.77258665
20TEC1.67812034
21MAP3K131.66314167
22BTK1.65165919
23FLT31.60343094
24NLK1.59883753
25SYK1.49822640
26RIPK41.45434858
27CHUK1.43625448
28GRK71.41533360
29CSF1R1.35627224
30CSK1.34997773
31NEK91.34381365
32EPHA31.34028890
33PIM11.33034524
34STK101.29402938
35ITK1.27847588
36NME21.27132658
37FGR1.26976931
38LCK1.26933666
39TGFBR21.21609782
40JAK21.20291554
41HCK1.18699378
42PIM21.18670564
43EPHB11.14059451
44RPS6KA41.13497211
45PBK1.11871865
46MST41.10752535
47MAP3K11.08696181
48GRK61.06119432
49CDC42BPA1.05137634
50TAOK11.01439281
51LYN0.98881364
52MAP3K20.94425250
53STK40.92455058
54MAP2K30.91881713
55IRAK10.88528686
56EIF2AK20.87391671
57NUAK10.87184553
58SIK10.85674911
59KDR0.85175673
60MAP3K100.84455124
61MAPK110.78295911
62CAMKK20.76859815
63MATK0.75487294
64TRPM70.74543918
65PKN20.69967394
66MARK30.68994959
67PDK10.68597840
68ACVR1B0.68374095
69TAOK20.66463035
70YES10.64803368
71PRKCQ0.62341152
72IRAK20.61013594
73LRRK20.60612716
74PTK60.60458515
75MAP2K60.59574085
76MAP3K110.59304060
77MST1R0.59123505
78CDK60.58511077
79FRK0.58003852
80RIPK10.56217269
81SIK30.55722300
82PDPK10.54436531
83MAPK70.54229585
84PIK3CG0.54121036
85CDK40.52491608
86PRKD20.50457394
87EEF2K0.50239081
88CLK10.50005748
89FES0.49663996
90DDR20.48929329
91TGFBR10.48497232
92PTK2B0.46690374
93ABL10.46100332
94TRIB30.45235501
95MELK0.44576570
96BMPR20.42622501
97MAPK40.41887193
98FER0.41293631
99CDK120.41181492
100PRKCD0.40668954
101PDGFRB0.39779174
102RPS6KA50.38905539
103FYN0.38810732
104STK30.38781301
105BCKDK0.37695879
106EGFR0.37670070
107MAP3K50.37055761
108HIPK20.36800631
109MAP3K30.36348440
110SGK30.31476791
111RPS6KA60.30273506
112MARK20.29755413
113DYRK1B0.29566396
114KSR20.29484903
115EIF2AK10.29231509
116SMG10.28921602
117ABL20.28456891
118MAPK30.28118983
119ADRBK20.27674110
120STK380.27596304
121IGF1R0.27498698
122PRKAA20.27273191
123WNK10.27270201
124CAMK1D0.26677711
125TNK20.26231610
126MAP2K20.26133142
127STK240.25788848
128TIE10.25131857
129MAPKAPK20.25075389
130MAP3K70.24944740
131SIK20.22608213

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051502.87605074
2Primary immunodeficiency_Homo sapiens_hsa053402.62703825
3Leishmaniasis_Homo sapiens_hsa051402.62272755
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.60303886
5Measles_Homo sapiens_hsa051622.54328243
6RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.51473440
7Allograft rejection_Homo sapiens_hsa053302.49998570
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.48570089
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.44223166
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.30441718
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.20093686
12Graft-versus-host disease_Homo sapiens_hsa053322.18239486
13Primary bile acid biosynthesis_Homo sapiens_hsa001202.02897834
14Caffeine metabolism_Homo sapiens_hsa002322.00837873
15Herpes simplex infection_Homo sapiens_hsa051681.91839880
16Influenza A_Homo sapiens_hsa051641.83491907
17Antigen processing and presentation_Homo sapiens_hsa046121.78702879
18Osteoclast differentiation_Homo sapiens_hsa043801.75873749
19Complement and coagulation cascades_Homo sapiens_hsa046101.73997899
20Legionellosis_Homo sapiens_hsa051341.73560254
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.70368830
22Jak-STAT signaling pathway_Homo sapiens_hsa046301.56676248
23Pertussis_Homo sapiens_hsa051331.55978378
24Malaria_Homo sapiens_hsa051441.50642024
25Toxoplasmosis_Homo sapiens_hsa051451.48024169
26Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.47840080
27TNF signaling pathway_Homo sapiens_hsa046681.45083924
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.43800480
29Hematopoietic cell lineage_Homo sapiens_hsa046401.43797840
30B cell receptor signaling pathway_Homo sapiens_hsa046621.39733616
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.35427076
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.34803795
33Autoimmune thyroid disease_Homo sapiens_hsa053201.26432882
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.25864121
35Tuberculosis_Homo sapiens_hsa051521.24548885
36Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.23204609
37African trypanosomiasis_Homo sapiens_hsa051431.16158666
38Hepatitis C_Homo sapiens_hsa051601.14511296
39Asthma_Homo sapiens_hsa053101.13040885
40Tryptophan metabolism_Homo sapiens_hsa003801.11550865
41Apoptosis_Homo sapiens_hsa042101.10421510
42Arginine biosynthesis_Homo sapiens_hsa002201.08912272
43Hepatitis B_Homo sapiens_hsa051611.07872944
44T cell receptor signaling pathway_Homo sapiens_hsa046601.07618668
45Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.05817143
46ABC transporters_Homo sapiens_hsa020101.03547153
47Chemokine signaling pathway_Homo sapiens_hsa040620.97608970
48Type I diabetes mellitus_Homo sapiens_hsa049400.93645933
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.89506850
50Peroxisome_Homo sapiens_hsa041460.88482089
51Drug metabolism - other enzymes_Homo sapiens_hsa009830.87280028
52Acute myeloid leukemia_Homo sapiens_hsa052210.87262702
53Viral myocarditis_Homo sapiens_hsa054160.86777665
54Shigellosis_Homo sapiens_hsa051310.83941253
55Histidine metabolism_Homo sapiens_hsa003400.80475843
56Other glycan degradation_Homo sapiens_hsa005110.77723747
57Fatty acid degradation_Homo sapiens_hsa000710.76578461
58Salmonella infection_Homo sapiens_hsa051320.76062471
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74205248
60Glycosaminoglycan degradation_Homo sapiens_hsa005310.71833091
61Rheumatoid arthritis_Homo sapiens_hsa053230.71759458
62PPAR signaling pathway_Homo sapiens_hsa033200.71729096
63Dorso-ventral axis formation_Homo sapiens_hsa043200.71286520
64Prolactin signaling pathway_Homo sapiens_hsa049170.70262937
65Selenocompound metabolism_Homo sapiens_hsa004500.68661530
66One carbon pool by folate_Homo sapiens_hsa006700.68541894
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.66248889
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66180425
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.64904264
70Chemical carcinogenesis_Homo sapiens_hsa052040.64816011
71Starch and sucrose metabolism_Homo sapiens_hsa005000.62088026
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61050638
73Non-small cell lung cancer_Homo sapiens_hsa052230.60547416
74Folate biosynthesis_Homo sapiens_hsa007900.58643362
75Retinol metabolism_Homo sapiens_hsa008300.58595884
76Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.58542125
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58151301
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58018795
79Amoebiasis_Homo sapiens_hsa051460.57890873
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57777467
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56686911
82VEGF signaling pathway_Homo sapiens_hsa043700.56232429
83Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54976592
84Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54356291
85AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.54220916
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53826692
87Nitrogen metabolism_Homo sapiens_hsa009100.53698899
88Lysosome_Homo sapiens_hsa041420.53495120
89beta-Alanine metabolism_Homo sapiens_hsa004100.51767947
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50719062
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.48388793
92Small cell lung cancer_Homo sapiens_hsa052220.48336683
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47361956
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.47171526
95Pentose phosphate pathway_Homo sapiens_hsa000300.45634997
96Vitamin digestion and absorption_Homo sapiens_hsa049770.45463354
97Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45046238
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44950270
99Phenylalanine metabolism_Homo sapiens_hsa003600.43927422
100Platelet activation_Homo sapiens_hsa046110.43599010
101Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43346811
102FoxO signaling pathway_Homo sapiens_hsa040680.43093477
103Viral carcinogenesis_Homo sapiens_hsa052030.42116398
104Renal cell carcinoma_Homo sapiens_hsa052110.42010263
105Epstein-Barr virus infection_Homo sapiens_hsa051690.41754564
106Chronic myeloid leukemia_Homo sapiens_hsa052200.38949092
107Sphingolipid metabolism_Homo sapiens_hsa006000.38610153
108HTLV-I infection_Homo sapiens_hsa051660.38259853
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.36935824
110Systemic lupus erythematosus_Homo sapiens_hsa053220.36763598
111Pancreatic cancer_Homo sapiens_hsa052120.35799639
112Type II diabetes mellitus_Homo sapiens_hsa049300.35789874
113Fat digestion and absorption_Homo sapiens_hsa049750.35471599
114Sulfur relay system_Homo sapiens_hsa041220.34718030
115Insulin resistance_Homo sapiens_hsa049310.33564038
116Endocytosis_Homo sapiens_hsa041440.32561492
117mTOR signaling pathway_Homo sapiens_hsa041500.31770303
118Phagosome_Homo sapiens_hsa041450.31239764
119Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.30565710
120Arachidonic acid metabolism_Homo sapiens_hsa005900.28750916
121HIF-1 signaling pathway_Homo sapiens_hsa040660.28349887
122Renin-angiotensin system_Homo sapiens_hsa046140.25730745
123Prostate cancer_Homo sapiens_hsa052150.25364577
124Phosphatidylinositol signaling system_Homo sapiens_hsa040700.25158938
125Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.24646924
126Mineral absorption_Homo sapiens_hsa049780.24041999
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.23017036
128Inositol phosphate metabolism_Homo sapiens_hsa005620.22394563
129Bladder cancer_Homo sapiens_hsa052190.21867118
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.20111516

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