DTX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Studies in Drosophila have identified this gene as encoding a positive regulator of the Notch-signaling pathway. The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix transcription factor activity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)5.64312203
2negative regulation of cell killing (GO:0031342)5.24895562
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.24895562
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.13945636
5mucosal-associated lymphoid tissue development (GO:0048537)5.09756747
6Peyers patch development (GO:0048541)5.09756747
7V(D)J recombination (GO:0033151)4.87359610
8synaptic vesicle maturation (GO:0016188)4.83302268
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.76725891
10vocalization behavior (GO:0071625)4.73500150
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.69577381
12germinal center formation (GO:0002467)4.49263310
13regulation of synaptic vesicle exocytosis (GO:2000300)4.41879031
14neuron cell-cell adhesion (GO:0007158)4.40908473
15layer formation in cerebral cortex (GO:0021819)4.37968162
16positive T cell selection (GO:0043368)4.36366318
17positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.34048642
18B cell proliferation (GO:0042100)4.33960296
19synaptic vesicle exocytosis (GO:0016079)4.32438272
20regulation of glutamate receptor signaling pathway (GO:1900449)4.26843657
21exploration behavior (GO:0035640)4.25490961
22ionotropic glutamate receptor signaling pathway (GO:0035235)4.11781735
23positive thymic T cell selection (GO:0045059)4.09838608
24protein localization to synapse (GO:0035418)4.07486122
25glutamate secretion (GO:0014047)3.94491023
26dendritic spine morphogenesis (GO:0060997)3.94140686
27regulation of synaptic vesicle transport (GO:1902803)3.79512618
28CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.78040644
29positive regulation of B cell differentiation (GO:0045579)3.77704239
30cellular response to interleukin-15 (GO:0071350)3.74454147
31neurotransmitter secretion (GO:0007269)3.71987599
32regulation of glycogen (starch) synthase activity (GO:2000465)3.64866347
33negative T cell selection (GO:0043383)3.62812670
34T cell selection (GO:0045058)3.61539981
35thymic T cell selection (GO:0045061)3.60048352
36positive regulation by host of viral transcription (GO:0043923)3.57316510
37long-term memory (GO:0007616)3.54634503
38T cell lineage commitment (GO:0002360)3.53751640
39glutamate receptor signaling pathway (GO:0007215)3.51748571
40negative regulation of synaptic transmission, GABAergic (GO:0032229)3.50763944
41pyrimidine nucleobase catabolic process (GO:0006208)3.49422178
42response to interleukin-15 (GO:0070672)3.47822927
43negative thymic T cell selection (GO:0045060)3.47315780
44auditory behavior (GO:0031223)3.43960446
45gamma-aminobutyric acid transport (GO:0015812)3.42647336
46regulation of long-term neuronal synaptic plasticity (GO:0048169)3.41990980
47regulation of neuronal synaptic plasticity (GO:0048168)3.39706102
48regulation of ARF protein signal transduction (GO:0032012)3.39475415
49synaptic transmission, glutamatergic (GO:0035249)3.39165675
50transmission of nerve impulse (GO:0019226)3.35879609
51cellular potassium ion homeostasis (GO:0030007)3.34794829
52sodium ion export (GO:0071436)3.34129444
53activation of MAPKKK activity (GO:0000185)3.32515101
54synaptic vesicle docking involved in exocytosis (GO:0016081)3.29269559
55response to pheromone (GO:0019236)3.27797574
56regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.27307345
57cerebellar Purkinje cell differentiation (GO:0021702)3.25150393
58positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.23677995
59activated T cell proliferation (GO:0050798)3.23446943
60neuronal ion channel clustering (GO:0045161)3.23153147
61positive regulation of gamma-delta T cell activation (GO:0046645)3.19108155
62regulation of synapse structural plasticity (GO:0051823)3.18219668
63neuron recognition (GO:0008038)3.17644203
64G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.17209445
65positive regulation of membrane potential (GO:0045838)3.16072585
66positive regulation of granulocyte differentiation (GO:0030854)3.15789816
67response to auditory stimulus (GO:0010996)3.15544432
68positive regulation of B cell proliferation (GO:0030890)3.14120595
69neurotransmitter catabolic process (GO:0042135)3.12761174
70positive regulation of synapse maturation (GO:0090129)3.12317185
71regulation of excitatory postsynaptic membrane potential (GO:0060079)3.12136737
72adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.11058023
73neurotransmitter-gated ion channel clustering (GO:0072578)3.09793755
74long-term synaptic potentiation (GO:0060291)3.08295376
75activation of protein kinase A activity (GO:0034199)3.08279144
76neuron-neuron synaptic transmission (GO:0007270)3.07344762
77establishment of mitochondrion localization (GO:0051654)3.07307048
78B cell receptor signaling pathway (GO:0050853)3.05135589
79natural killer cell differentiation (GO:0001779)3.04602964
80regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.04476168
81regulation of B cell differentiation (GO:0045577)3.03377011
82regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.02050086
83dendrite morphogenesis (GO:0048813)3.01549323
84regulation of B cell receptor signaling pathway (GO:0050855)3.01357709
85synaptic vesicle endocytosis (GO:0048488)2.99834224
86regulation of dendritic spine morphogenesis (GO:0061001)2.99668558
87postsynaptic membrane organization (GO:0001941)2.99409575
88regulation of gamma-delta T cell activation (GO:0046643)2.99179753
89regulation of histone H3-K9 methylation (GO:0051570)2.98371180
90regulation of postsynaptic membrane potential (GO:0060078)2.97426937
91positive regulation of neurotransmitter transport (GO:0051590)2.96399653
92prepulse inhibition (GO:0060134)2.96225551
93B cell homeostasis (GO:0001782)2.95462821
94gamma-aminobutyric acid signaling pathway (GO:0007214)2.94715599
95establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.93860864
96mitochondrion transport along microtubule (GO:0047497)2.93860864
97snRNA transcription (GO:0009301)2.92477558
98central nervous system projection neuron axonogenesis (GO:0021952)2.92066817
99negative regulation of microtubule polymerization (GO:0031115)2.90594170
100neuronal action potential propagation (GO:0019227)2.90146415
101neurotransmitter transport (GO:0006836)2.89886830
102negative regulation of histone methylation (GO:0031061)2.89207572
103positive regulation of neurotransmitter secretion (GO:0001956)2.89028170
104proline transport (GO:0015824)2.88612246
105regulation of granulocyte differentiation (GO:0030852)2.88122740
106regulation of synaptic plasticity (GO:0048167)2.87558956
107L-amino acid import (GO:0043092)2.87359390
108negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.87183973
109response to nerve growth factor (GO:1990089)2.84816184
110cellular response to nerve growth factor stimulus (GO:1990090)2.84816184
111positive regulation of Rap GTPase activity (GO:0032854)2.84111787
112positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.83987968
113presynaptic membrane organization (GO:0097090)2.82503137
114regulation of Rap GTPase activity (GO:0032317)2.81308790
115axonal fasciculation (GO:0007413)2.80599989
116signal complex assembly (GO:0007172)2.78322339
117regulation of isotype switching to IgG isotypes (GO:0048302)2.77656886
118regulation of neurotransmitter secretion (GO:0046928)2.77021280
119clathrin coat assembly (GO:0048268)2.76203476
120negative regulation of amino acid transport (GO:0051956)2.76089221
121regulation of gamma-delta T cell differentiation (GO:0045586)2.74715639
122positive regulation of synaptic transmission, GABAergic (GO:0032230)2.73105179
123intraspecies interaction between organisms (GO:0051703)2.72855922
124social behavior (GO:0035176)2.72855922
125positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.72539931
126regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.72539931
127positive regulation of protein homooligomerization (GO:0032464)2.72449327
128response to histamine (GO:0034776)2.72087730
129membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.71655161
130mechanosensory behavior (GO:0007638)2.71450409
131T cell receptor signaling pathway (GO:0050852)2.70171740
132cerebellar granule cell differentiation (GO:0021707)2.70132644
133nucleobase catabolic process (GO:0046113)2.69943998
134response to dietary excess (GO:0002021)2.69338119
135neuromuscular process controlling balance (GO:0050885)2.69308209
136regulation of neurotransmitter levels (GO:0001505)2.69233824
137positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.68514654
138cell migration in hindbrain (GO:0021535)2.67970150
139dopamine receptor signaling pathway (GO:0007212)2.67213526
140positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.67004309
141regulation of synaptic transmission, glutamatergic (GO:0051966)2.66318317
142positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.64736417
143antigen receptor-mediated signaling pathway (GO:0050851)2.64675340
144cerebral cortex neuron differentiation (GO:0021895)2.60312492
145nucleosome disassembly (GO:0006337)2.60009610
146protein-DNA complex disassembly (GO:0032986)2.60009610
147regulation of germinal center formation (GO:0002634)2.58552705
148hypothalamus development (GO:0021854)2.54964581
149regulation of circadian sleep/wake cycle, sleep (GO:0045187)2.54563490
150regulation of circadian sleep/wake cycle (GO:0042749)2.54563490
151positive regulation of B cell activation (GO:0050871)2.54141248
152T cell homeostasis (GO:0043029)2.53264060

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.29469754
2IKZF1_21737484_ChIP-ChIP_HCT116_Human3.03155071
3THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.83543137
4REST_21632747_ChIP-Seq_MESCs_Mouse2.80001251
5RARB_27405468_Chip-Seq_BRAIN_Mouse2.72735213
6* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.71458481
7EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.70491075
8DROSHA_22980978_ChIP-Seq_HELA_Human2.63410946
9VDR_21846776_ChIP-Seq_THP-1_Human2.59862649
10CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.49715494
11* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.44173121
12* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.36646567
13REST_18959480_ChIP-ChIP_MESCs_Mouse2.32357098
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.24562679
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.24166928
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.24150297
17VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.22435321
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.21321758
19EZH2_18974828_ChIP-Seq_MESCs_Mouse2.21321758
20GBX2_23144817_ChIP-Seq_PC3_Human2.18324961
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.15086904
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.12720315
23* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.11883472
24AR_21572438_ChIP-Seq_LNCaP_Human2.11820906
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.10058295
26JARID2_20075857_ChIP-Seq_MESCs_Mouse2.08563065
27EZH2_27304074_Chip-Seq_ESCs_Mouse2.04267664
28* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.02366783
29* EZH2_27294783_Chip-Seq_ESCs_Mouse2.00026086
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.99673775
31* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.97227138
32CIITA_25753668_ChIP-Seq_RAJI_Human1.93328250
33* MYC_22102868_ChIP-Seq_BL_Human1.93071223
34SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.88685449
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88044642
36* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.85427134
37TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82585568
38* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.81335456
39BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.78801092
40* KDM2B_26808549_Chip-Seq_DND41_Human1.73656510
41RUNX_20019798_ChIP-Seq_JUKART_Human1.67786372
42DNAJC2_21179169_ChIP-ChIP_NT2_Human1.63682997
43MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.62332653
44E2F7_22180533_ChIP-Seq_HELA_Human1.60782759
45* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.56312030
46KDM2B_26808549_Chip-Seq_K562_Human1.54307196
47* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.50395770
48* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.48363156
49* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.47082954
50KDM2B_26808549_Chip-Seq_JURKAT_Human1.45761283
51* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.40471999
52GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.39885363
53* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.39201655
54RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.38669438
55GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.38640114
56EED_16625203_ChIP-ChIP_MESCs_Mouse1.37853987
57* RING1B_27294783_Chip-Seq_ESCs_Mouse1.37646823
58STAT6_21828071_ChIP-Seq_BEAS2B_Human1.37323120
59P68_20966046_ChIP-Seq_HELA_Human1.35823129
60WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.33976369
61VDR_24763502_ChIP-Seq_THP-1_Human1.33436673
62MAF_26560356_Chip-Seq_TH1_Human1.31715551
63SMAD_19615063_ChIP-ChIP_OVARY_Human1.31232143
64MAF_26560356_Chip-Seq_TH2_Human1.30862004
65IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.30733371
66CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.26820663
67EGR1_19374776_ChIP-ChIP_THP-1_Human1.25834208
68CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25586314
69SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24862504
70TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.24240005
71ZNF274_21170338_ChIP-Seq_K562_Hela1.21903652
72PU.1_20513432_ChIP-Seq_Bcells_Mouse1.20872799
73SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.20801597
74TET1_21451524_ChIP-Seq_MESCs_Mouse1.18126439
75* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.16259858
76PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.14723920
77ERG_21242973_ChIP-ChIP_JURKAT_Human1.14300761
78RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.14065753
79SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13601211
80RING1B_27294783_Chip-Seq_NPCs_Mouse1.13480293
81BCOR_27268052_Chip-Seq_Bcells_Human1.13188360
82TCF7_22412390_ChIP-Seq_EML_Mouse1.12463357
83* AR_19668381_ChIP-Seq_PC3_Human1.12092104
84BCL6_27268052_Chip-Seq_Bcells_Human1.11177475
85KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.10591810
86TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09122506
87SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.08918283
88SA1_27219007_Chip-Seq_ERYTHROID_Human1.07806115
89ELF1_20517297_ChIP-Seq_JURKAT_Human1.07602248
90TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06206189
91SOX2_21211035_ChIP-Seq_LN229_Gbm1.05916346
92WDR5_24793694_ChIP-Seq_LNCAP_Human1.05366131
93CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05017081
94RNF2_27304074_Chip-Seq_NSC_Mouse1.03378324
95P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02698443
96TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01404006
97TAF15_26573619_Chip-Seq_HEK293_Human1.01221220
98PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00500753
99CTCF_27219007_Chip-Seq_ERYTHROID_Human0.99700799
100PRDM14_20953172_ChIP-Seq_ESCs_Human0.99442676
101WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98835363
102SMAD4_21799915_ChIP-Seq_A2780_Human0.98606692
103STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.98068156
104OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.96710647
105* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.96619351
106CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95752264
107GATA1_19941827_ChIP-Seq_MEL_Mouse0.95743291
108TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95371190
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95371190
110MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.94941699
111NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94916775
112LXR_22292898_ChIP-Seq_THP-1_Human0.93880326
113SPI1_23127762_ChIP-Seq_K562_Human0.92346652
114SRY_22984422_ChIP-ChIP_TESTIS_Rat0.92072353
115UTX_26944678_Chip-Seq_JUKART_Human0.91772285
116MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.91757876
117CTCF_21964334_ChIP-Seq_BJAB-B_Human0.90138380
118ELK4_26923725_Chip-Seq_MESODERM_Mouse0.90095907
119SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.88739407
120ARNT_22903824_ChIP-Seq_MCF-7_Human0.88087873
121MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.88043174
122CREB1_26743006_Chip-Seq_LNCaP_Human0.87973525
123* STAT3_23295773_ChIP-Seq_U87_Human0.86760609
124RUNX1_22412390_ChIP-Seq_EML_Mouse0.86734990
125SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.85810933
126P300_27268052_Chip-Seq_Bcells_Human0.85789831
127EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.85547526
128ETS1_21867929_ChIP-Seq_TH2_Mouse0.85390555
129GATA1_26923725_Chip-Seq_HPCs_Mouse0.85324546
130FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85309802
131AHR_22903824_ChIP-Seq_MCF-7_Human0.84914445
132CTCF_27219007_Chip-Seq_Bcells_Human0.84672688
133TCF4_23295773_ChIP-Seq_U87_Human0.84107470
134CBX2_27304074_Chip-Seq_ESCs_Mouse0.83991009
135ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.83561390
136PHF8_20622854_ChIP-Seq_HELA_Human0.83503575
137SMAD3_21741376_ChIP-Seq_ESCs_Human0.83383408
138NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.83178120
139SMC4_20622854_ChIP-Seq_HELA_Human0.83019766
140SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.82961149
141MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.80776242
142SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.80573216
143TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.80293819
144CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80162922
145AR_25329375_ChIP-Seq_VCAP_Human0.80051369
146OCT4_19829295_ChIP-Seq_ESCs_Human0.79770981
147SMAD4_21741376_ChIP-Seq_HESCs_Human0.79120932

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.68779171
2MP0003880_abnormal_central_pattern3.96353393
3MP0003635_abnormal_synaptic_transmissio3.78289131
4MP0005423_abnormal_somatic_nervous3.45295683
5MP0002063_abnormal_learning/memory/cond3.01498578
6MP0009745_abnormal_behavioral_response3.01323116
7MP0001986_abnormal_taste_sensitivity2.91601110
8MP0002064_seizures2.75192782
9MP0004270_analgesia2.71773568
10MP0002572_abnormal_emotion/affect_behav2.59496453
11MP0009046_muscle_twitch2.41407224
12MP0001486_abnormal_startle_reflex2.31613029
13MP0001968_abnormal_touch/_nociception2.26166587
14MP0000778_abnormal_nervous_system2.24586356
15MP0003787_abnormal_imprinting2.24422381
16MP0001440_abnormal_grooming_behavior2.15156459
17MP0002272_abnormal_nervous_system2.11630080
18MP0008569_lethality_at_weaning2.10639526
19MP0001984_abnormal_olfaction1.98241116
20MP0003303_peritoneal_inflammation1.96294956
21MP0002822_catalepsy1.93853065
22MP0005645_abnormal_hypothalamus_physiol1.92789623
23MP0004130_abnormal_muscle_cell1.91945242
24MP0002734_abnormal_mechanical_nocicepti1.90756411
25MP0004381_abnormal_hair_follicle1.88225213
26* MP0003763_abnormal_thymus_physiology1.86517293
27MP0002184_abnormal_innervation1.86361253
28MP0002557_abnormal_social/conspecific_i1.86025210
29MP0005666_abnormal_adipose_tissue1.78989459
30MP0005670_abnormal_white_adipose1.74799723
31MP0002733_abnormal_thermal_nociception1.74495342
32MP0004885_abnormal_endolymph1.73022086
33MP0002067_abnormal_sensory_capabilities1.71958396
34MP0002909_abnormal_adrenal_gland1.70803764
35MP0004811_abnormal_neuron_physiology1.70028702
36MP0002735_abnormal_chemical_nociception1.68918128
37MP0006276_abnormal_autonomic_nervous1.68688514
38MP0004185_abnormal_adipocyte_glucose1.67705319
39MP0003329_amyloid_beta_deposits1.67211583
40MP0001501_abnormal_sleep_pattern1.65702664
41MP0005386_behavior/neurological_phenoty1.64390322
42MP0004924_abnormal_behavior1.64390322
43MP0001970_abnormal_pain_threshold1.61503001
44MP0008961_abnormal_basal_metabolism1.58231560
45MP0002736_abnormal_nociception_after1.58086266
46MP0000955_abnormal_spinal_cord1.46231097
47MP0001502_abnormal_circadian_rhythm1.45481683
48MP0001800_abnormal_humoral_immune1.41540754
49MP0005387_immune_system_phenotype1.36637212
50MP0001790_abnormal_immune_system1.36637212
51MP0002882_abnormal_neuron_morphology1.35777286
52MP0004742_abnormal_vestibular_system1.31064267
53MP0002152_abnormal_brain_morphology1.29898729
54MP0005646_abnormal_pituitary_gland1.28389936
55MP0010386_abnormal_urinary_bladder1.28230161
56MP0002066_abnormal_motor_capabilities/c1.27559146
57MP0003122_maternal_imprinting1.24973013
58MP0002396_abnormal_hematopoietic_system1.23982802
59MP0004510_myositis1.23602857
60MP0000569_abnormal_digit_pigmentation1.22961093
61MP0005394_taste/olfaction_phenotype1.22112203
62MP0005499_abnormal_olfactory_system1.22112203
63MP0003959_abnormal_lean_body1.21349994
64MP0004142_abnormal_muscle_tone1.21122224
65MP0000685_abnormal_immune_system1.18365843
66MP0009780_abnormal_chondrocyte_physiolo1.17905870
67MP0005535_abnormal_body_temperature1.17370795
68MP0008877_abnormal_DNA_methylation1.16575068
69MP0005375_adipose_tissue_phenotype1.15716848
70MP0009115_abnormal_fat_cell1.12952930
71MP0003879_abnormal_hair_cell1.12873324
72MP0004858_abnormal_nervous_system1.12859488
73MP0001905_abnormal_dopamine_level1.10406901
74MP0001529_abnormal_vocalization1.08252399
75MP0003123_paternal_imprinting1.06494359
76MP0000703_abnormal_thymus_morphology1.06309461
77MP0008057_abnormal_DNA_replication1.05351898
78MP0003633_abnormal_nervous_system1.04424427
79MP0003868_abnormal_feces_composition1.04252869
80MP0000631_abnormal_neuroendocrine_gland1.04162042
81* MP0002398_abnormal_bone_marrow1.01133604
82* MP0002722_abnormal_immune_system1.00380209
83MP0002971_abnormal_brown_adipose1.00021728
84MP0005671_abnormal_response_to0.99064540
85MP0005075_abnormal_melanosome_morpholog0.99063529
86* MP0002420_abnormal_adaptive_immunity0.96440225
87MP0003866_abnormal_defecation0.96312547
88MP0008995_early_reproductive_senescence0.95923141
89MP0008874_decreased_physiological_sensi0.95477142
90MP0003436_decreased_susceptibility_to0.94955651
91MP0003631_nervous_system_phenotype0.94124692
92MP0002970_abnormal_white_adipose0.92447897
93* MP0001819_abnormal_immune_cell0.91272036
94MP0005448_abnormal_energy_balance0.89353029
95MP0003861_abnormal_nervous_system0.88912072
96* MP0005000_abnormal_immune_tolerance0.87945271
97* MP0002429_abnormal_blood_cell0.86960650
98* MP0002452_abnormal_antigen_presenting0.85164664
99MP0003121_genomic_imprinting0.85048093
100MP0002069_abnormal_eating/drinking_beha0.83957118
101MP0003634_abnormal_glial_cell0.83703472
102MP0005025_abnormal_response_to0.82600039
103* MP0000716_abnormal_immune_system0.82235919
104MP0002653_abnormal_ependyma_morphology0.82141411
105MP0008872_abnormal_physiological_respon0.82109752
106MP0009278_abnormal_bone_marrow0.81493216
107* MP0002723_abnormal_immune_serum0.80915544
108MP0002138_abnormal_hepatobiliary_system0.80138282
109MP0006072_abnormal_retinal_apoptosis0.78490653
110MP0002229_neurodegeneration0.78155232
111MP0003183_abnormal_peptide_metabolism0.76536422
112MP0001835_abnormal_antigen_presentation0.75854292
113MP0002752_abnormal_somatic_nervous0.74626000
114MP0002139_abnormal_hepatobiliary_system0.73627250
115MP0005452_abnormal_adipose_tissue0.72973622
116MP0000920_abnormal_myelination0.72570967
117MP0000604_amyloidosis0.70920244
118MP0001963_abnormal_hearing_physiology0.70892349
119MP0002078_abnormal_glucose_homeostasis0.69822249
120MP0003690_abnormal_glial_cell0.69617907
121MP0003632_abnormal_nervous_system0.68930353
122MP0001873_stomach_inflammation0.68703024
123MP0002009_preneoplasia0.67243841
124MP0005334_abnormal_fat_pad0.67243620
125MP0010769_abnormal_survival0.66324663
126MP0005310_abnormal_salivary_gland0.65288670
127MP0001348_abnormal_lacrimal_gland0.64972597
128MP0010768_mortality/aging0.64255803
129MP0003045_fibrosis0.63260036
130MP0002638_abnormal_pupillary_reflex0.62379580
131* MP0000689_abnormal_spleen_morphology0.61129268

Predicted human phenotypes

RankGene SetZ-score
1B lymphocytopenia (HP:0010976)4.93305607
2Myokymia (HP:0002411)4.77667112
3Focal motor seizures (HP:0011153)4.51350400
4Cellulitis (HP:0100658)4.38508895
5Abnormality of B cell number (HP:0010975)4.18960830
6Focal seizures (HP:0007359)4.10597368
7Meningitis (HP:0001287)3.97005301
8Visual hallucinations (HP:0002367)3.90793997
9Hypoplasia of the thymus (HP:0000778)3.80325756
10Ankle clonus (HP:0011448)3.51312367
11Atonic seizures (HP:0010819)3.48476675
12Supranuclear gaze palsy (HP:0000605)3.45979574
13Agammaglobulinemia (HP:0004432)3.36301346
14Febrile seizures (HP:0002373)3.32662873
15Epileptic encephalopathy (HP:0200134)3.29850398
16Amyotrophic lateral sclerosis (HP:0007354)3.24748686
17Severe combined immunodeficiency (HP:0004430)3.20672367
18Papilledema (HP:0001085)3.19146643
19Progressive cerebellar ataxia (HP:0002073)3.08671722
20Absence seizures (HP:0002121)2.97869050
21Combined immunodeficiency (HP:0005387)2.96001903
22Gastrointestinal stroma tumor (HP:0100723)2.94425447
23Deep palmar crease (HP:0006191)2.93720733
24Abnormality of binocular vision (HP:0011514)2.91933005
25Diplopia (HP:0000651)2.91933005
26Mediastinal lymphadenopathy (HP:0100721)2.87296655
27Broad-based gait (HP:0002136)2.84614071
28Truncal ataxia (HP:0002078)2.81353046
29Recurrent sinusitis (HP:0011108)2.78482867
30Impulsivity (HP:0100710)2.76055346
31Urinary urgency (HP:0000012)2.75966501
32Spastic gait (HP:0002064)2.72873355
33Hemiplegia (HP:0002301)2.71284622
34Sepsis (HP:0100806)2.69321609
35Dialeptic seizures (HP:0011146)2.61449051
36Progressive inability to walk (HP:0002505)2.61421099
37Impaired vibration sensation in the lower limbs (HP:0002166)2.58360693
38Recurrent bronchitis (HP:0002837)2.57820674
39Excessive salivation (HP:0003781)2.57494771
40Drooling (HP:0002307)2.57494771
41Status epilepticus (HP:0002133)2.56953501
42Agitation (HP:0000713)2.51059510
43Depression (HP:0000716)2.49789604
44T lymphocytopenia (HP:0005403)2.49129433
45Thyroiditis (HP:0100646)2.48229113
46Hemiparesis (HP:0001269)2.48093358
47Chronic sinusitis (HP:0011109)2.46401177
48Poor eye contact (HP:0000817)2.46322117
49Panhypogammaglobulinemia (HP:0003139)2.43959839
50Abnormal delayed hypersensitivity skin test (HP:0002963)2.43733640
51Mutism (HP:0002300)2.42953585
52Megalencephaly (HP:0001355)2.41704351
53Osteomyelitis (HP:0002754)2.41056373
54Urinary bladder sphincter dysfunction (HP:0002839)2.40326633
55Abnormal eating behavior (HP:0100738)2.39544098
56Insomnia (HP:0100785)2.38323481
57Abnormality of the lower motor neuron (HP:0002366)2.37859361
58Limb dystonia (HP:0002451)2.37123742
59Impaired social interactions (HP:0000735)2.36327180
60Abnormal social behavior (HP:0012433)2.36327180
61Generalized tonic-clonic seizures (HP:0002069)2.34507852
62Dysmetria (HP:0001310)2.33601200
63Abnormality of the fingertips (HP:0001211)2.32505213
64Action tremor (HP:0002345)2.31696919
65Lymphoma (HP:0002665)2.31293708
66Vasculitis (HP:0002633)2.30859145
67Abnormality of T cell number (HP:0011839)2.29181520
68Nasal polyposis (HP:0100582)2.28825416
69Amblyopia (HP:0000646)2.27703226
70Hyperventilation (HP:0002883)2.27263712
71Stereotypic behavior (HP:0000733)2.23912849
72Recurrent pneumonia (HP:0006532)2.23176360
73Hyperacusis (HP:0010780)2.22550800
74Impaired smooth pursuit (HP:0007772)2.22319311
75Recurrent otitis media (HP:0000403)2.22035277
76Lymphopenia (HP:0001888)2.21904912
77Verrucae (HP:0200043)2.21537475
78Papilloma (HP:0012740)2.21537475
79Abnormality of the corticospinal tract (HP:0002492)2.19042023
80Postural instability (HP:0002172)2.18533120
81Polyphagia (HP:0002591)2.16107436
82Recurrent lower respiratory tract infections (HP:0002783)2.15538908
83Abnormality of ocular smooth pursuit (HP:0000617)2.12120548
84Recurrent fungal infections (HP:0002841)2.11511749
85Aplasia/Hypoplasia of the thymus (HP:0010515)2.10664158
86Pointed chin (HP:0000307)2.09469939
87Macroorchidism (HP:0000053)2.07925740
88Obstructive sleep apnea (HP:0002870)2.07266629
89Abnormality of cells of the lymphoid lineage (HP:0012140)2.07060108
90Hypercortisolism (HP:0001578)2.06663331
91Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.05802681
92Neuronal loss in central nervous system (HP:0002529)2.04440706
93Diminished motivation (HP:0000745)2.04309324
94Genetic anticipation (HP:0003743)2.02749735
95Emphysema (HP:0002097)2.02046110
96Obsessive-compulsive behavior (HP:0000722)2.00798741
97Increased IgE level (HP:0003212)1.99722754
98Peripheral hypomyelination (HP:0007182)1.99634209
99Limb hypertonia (HP:0002509)1.98894371
100Dysdiadochokinesis (HP:0002075)1.96967103
101Colitis (HP:0002583)1.96289657
102Aqueductal stenosis (HP:0002410)1.96150764
103Gaze-evoked nystagmus (HP:0000640)1.94823133
104Viral hepatitis (HP:0006562)1.93212323
105Encephalitis (HP:0002383)1.92481414
106Intellectual disability, severe (HP:0010864)1.90179865
107Cerebral inclusion bodies (HP:0100314)1.90129376
108Neoplasm of the heart (HP:0100544)1.89750658
109Anxiety (HP:0000739)1.88233847
110Neurofibrillary tangles (HP:0002185)1.88066841
111Renovascular hypertension (HP:0100817)1.87688454
112Abnormality of salivation (HP:0100755)1.87505650
113Restrictive lung disease (HP:0002091)1.86216193
114IgM deficiency (HP:0002850)1.85315195
115Abnormal hair whorl (HP:0010721)1.84948187
116IgA deficiency (HP:0002720)1.84869825
117Inappropriate behavior (HP:0000719)1.83878579
118Neoplasm of the adrenal cortex (HP:0100641)1.83439380
119Lower limb muscle weakness (HP:0007340)1.82556392
120Neonatal hypoglycemia (HP:0001998)1.81083129
121Overriding aorta (HP:0002623)1.80031952
122Sacral dimple (HP:0000960)1.79695736
123Abnormality of hair growth rate (HP:0011363)1.78653627
124Slow-growing hair (HP:0002217)1.78653627
125Torticollis (HP:0000473)1.78253312
126Generalized hypotonia (HP:0001290)1.77676068
127Elfin facies (HP:0004428)1.76926897
128Abnormality of oral frenula (HP:0000190)1.76420706
129Heterotopia (HP:0002282)1.76213182
130Akinesia (HP:0002304)1.75858684
131Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.74918328
132Dysphonia (HP:0001618)1.74482618
133Failure to thrive in infancy (HP:0001531)1.74399802
134Inability to walk (HP:0002540)1.74359073
135Apathy (HP:0000741)1.73862438
136Tented upper lip vermilion (HP:0010804)1.73177700
137Recurrent viral infections (HP:0004429)1.73124261
138Sporadic (HP:0003745)1.72870458
139Absent speech (HP:0001344)1.72514184
140Inflammation of the large intestine (HP:0002037)1.72138782
141Bronchitis (HP:0012387)1.71815548
142Chronic otitis media (HP:0000389)1.70939440
143Gastrointestinal inflammation (HP:0004386)1.70445149
144Testicular neoplasm (HP:0010788)1.69404096
145Clonus (HP:0002169)1.68889864

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.13342344
2MARK14.10032984
3MAP3K93.61893509
4MAP4K13.17726582
5NTRK33.04843397
6NTRK23.00277783
7SIK22.90452736
8GRK62.36244589
9MAP3K42.25948246
10TYRO32.23493976
11EPHA42.14465792
12MINK11.97187808
13PAK61.80007887
14SMG11.72796140
15MAP3K131.70388775
16DAPK21.68614314
17TRIB31.68339107
18BTK1.60721568
19CAMK1D1.60191773
20MAP2K71.52549498
21PNCK1.49456493
22PRKCH1.47421251
23FES1.45769067
24PRPF4B1.41136461
25RIPK41.41057302
26UHMK11.40659117
27ICK1.39200763
28MAPK131.39128610
29ALK1.35336293
30TNIK1.34084416
31CDK41.31784215
32CDK51.31222157
33MAP3K121.30388996
34STK111.29939836
35KSR11.29852750
36IRAK21.27692839
37NLK1.25629319
38TNK21.24913635
39PHKG21.24702336
40PHKG11.24702336
41MARK21.23575016
42MAP3K101.17703581
43TXK1.15437272
44MAPK41.14600083
45CAMK11.14384721
46SYK1.12201161
47ITK1.11443636
48SIK31.08149969
49CAMKK21.08006706
50MAP3K111.05950173
51DYRK1A1.02719973
52CSNK1G21.01373717
53DAPK10.98298183
54CSF1R0.94954400
55MAPK110.94438536
56CDK190.93916518
57CAMKK10.93858817
58TAOK10.92463179
59KSR20.90248369
60LYN0.88362211
61JAK10.87967887
62FGFR20.86641910
63HCK0.85843093
64STK380.85651612
65EEF2K0.84476857
66CDC42BPA0.83890504
67CAMK40.83186436
68PRKCQ0.82366296
69PRKD30.78879190
70IRAK40.78302032
71CSNK1G30.77478357
72CSNK1A1L0.76836827
73CLK10.75885107
74MAP2K40.75760189
75PRKCG0.75553480
76FGR0.74952705
77FYN0.74376425
78SGK30.72597748
79RIPK10.71610380
80FGFR30.69983550
81PKN10.68946704
82MAPK120.67242501
83HIPK20.66962402
84SGK20.65893923
85PDK10.65552532
86PRKD20.65422803
87ARAF0.65331174
88CAMK1G0.64405752
89NTRK10.64224069
90SIK10.63987707
91TLK10.63963538
92BRAF0.63913501
93CDK180.63483469
94CDK150.62840868
95PAK30.60993898
96CSK0.60765728
97SGK4940.59082318
98SGK2230.59082318
99BRD40.58783540
100CDK11A0.57319660
101CASK0.57011294
102CDK120.56369091
103TAOK20.55727371
104RPS6KA20.55368742
105DYRK20.54469520
106PRKAA10.54172925
107BLK0.54135780
108LCK0.53830574
109CSNK1G10.53222520
110CAMK2B0.52882078
111RET0.52657887
112WNK30.52132197
113SGK10.51697112
114GRK50.51121047
115PRKCZ0.51000100
116CDK140.49578279
117MARK30.48687767
118CAMK2A0.48122954
119MAP3K70.48049817
120STK100.47945461
121MAPK100.42500726
122ROCK20.41003496
123PLK20.40942995
124MAP2K20.40723093
125MAPK70.40169772
126CDC70.39650232
127RPS6KC10.36616630
128RPS6KL10.36616630
129TESK20.36334114
130JAK30.36301790
131CDK80.35016191
132RPS6KA30.34107482
133GSK3B0.33785276
134RPS6KB10.32901532
135MAPK30.32245004

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.87552515
2Olfactory transduction_Homo sapiens_hsa047402.47388082
3Long-term potentiation_Homo sapiens_hsa047202.27576419
4Morphine addiction_Homo sapiens_hsa050322.18765676
5Primary immunodeficiency_Homo sapiens_hsa053402.17617978
6Synaptic vesicle cycle_Homo sapiens_hsa047212.16814684
7Glutamatergic synapse_Homo sapiens_hsa047242.16758185
8GABAergic synapse_Homo sapiens_hsa047272.12107540
9Circadian entrainment_Homo sapiens_hsa047132.08968631
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.06135850
11B cell receptor signaling pathway_Homo sapiens_hsa046621.89077680
12Dopaminergic synapse_Homo sapiens_hsa047281.81552795
13T cell receptor signaling pathway_Homo sapiens_hsa046601.78579802
14Amphetamine addiction_Homo sapiens_hsa050311.77931535
15Salivary secretion_Homo sapiens_hsa049701.76056877
16Gastric acid secretion_Homo sapiens_hsa049711.71647363
17Cholinergic synapse_Homo sapiens_hsa047251.66777486
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.65814663
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.64602682
20Insulin secretion_Homo sapiens_hsa049111.53820158
21Renin secretion_Homo sapiens_hsa049241.49434657
22Cocaine addiction_Homo sapiens_hsa050301.42405496
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.42157716
24Phosphatidylinositol signaling system_Homo sapiens_hsa040701.41810815
25Long-term depression_Homo sapiens_hsa047301.41690334
26Oxytocin signaling pathway_Homo sapiens_hsa049211.41029977
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.37524799
28Axon guidance_Homo sapiens_hsa043601.32736765
29Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.31986769
30GnRH signaling pathway_Homo sapiens_hsa049121.29999575
31Taste transduction_Homo sapiens_hsa047421.29870517
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.29449897
33Estrogen signaling pathway_Homo sapiens_hsa049151.25343760
34Systemic lupus erythematosus_Homo sapiens_hsa053221.23500691
35Dorso-ventral axis formation_Homo sapiens_hsa043201.22949706
36Serotonergic synapse_Homo sapiens_hsa047261.20955188
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.20052113
38Calcium signaling pathway_Homo sapiens_hsa040201.19645009
39Allograft rejection_Homo sapiens_hsa053301.18677319
40Gap junction_Homo sapiens_hsa045401.18613509
41Asthma_Homo sapiens_hsa053101.18351296
42Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.17059025
43ErbB signaling pathway_Homo sapiens_hsa040121.13882793
44cAMP signaling pathway_Homo sapiens_hsa040241.12547960
45Cyanoamino acid metabolism_Homo sapiens_hsa004601.11611267
46Neurotrophin signaling pathway_Homo sapiens_hsa047221.11364004
47Autoimmune thyroid disease_Homo sapiens_hsa053201.11110408
48Chemokine signaling pathway_Homo sapiens_hsa040621.08042509
49Glioma_Homo sapiens_hsa052141.07451229
50Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.06824644
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.05210184
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.04692648
53Colorectal cancer_Homo sapiens_hsa052101.03721429
54MAPK signaling pathway_Homo sapiens_hsa040101.02765674
55Phospholipase D signaling pathway_Homo sapiens_hsa040720.99716326
56Prion diseases_Homo sapiens_hsa050200.99198683
57Type II diabetes mellitus_Homo sapiens_hsa049300.98641833
58Endometrial cancer_Homo sapiens_hsa052130.98180376
59cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95185895
60Choline metabolism in cancer_Homo sapiens_hsa052310.94321879
61Non-small cell lung cancer_Homo sapiens_hsa052230.93682272
62Graft-versus-host disease_Homo sapiens_hsa053320.92971546
63VEGF signaling pathway_Homo sapiens_hsa043700.88090340
64Melanogenesis_Homo sapiens_hsa049160.87454777
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86843429
66NF-kappa B signaling pathway_Homo sapiens_hsa040640.86499445
67* Notch signaling pathway_Homo sapiens_hsa043300.86416499
68Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84740193
69mTOR signaling pathway_Homo sapiens_hsa041500.83799153
70Renal cell carcinoma_Homo sapiens_hsa052110.83736938
71Pancreatic secretion_Homo sapiens_hsa049720.83563573
72Staphylococcus aureus infection_Homo sapiens_hsa051500.81560440
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81313409
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79427757
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.78786041
76Leishmaniasis_Homo sapiens_hsa051400.76289947
77Osteoclast differentiation_Homo sapiens_hsa043800.74957152
78Tuberculosis_Homo sapiens_hsa051520.74180206
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.74070452
80Toll-like receptor signaling pathway_Homo sapiens_hsa046200.73133220
81Oocyte meiosis_Homo sapiens_hsa041140.72177388
82Prostate cancer_Homo sapiens_hsa052150.71859349
83Endocytosis_Homo sapiens_hsa041440.71229026
84Hepatitis B_Homo sapiens_hsa051610.71077735
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69491594
86Inositol phosphate metabolism_Homo sapiens_hsa005620.69320357
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.68325704
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68298952
89Ras signaling pathway_Homo sapiens_hsa040140.67321861
90AMPK signaling pathway_Homo sapiens_hsa041520.65651374
91Base excision repair_Homo sapiens_hsa034100.64652979
92Rap1 signaling pathway_Homo sapiens_hsa040150.63686187
93Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63670705
94Wnt signaling pathway_Homo sapiens_hsa043100.62113569
95Thyroid hormone synthesis_Homo sapiens_hsa049180.61598258
96Alcoholism_Homo sapiens_hsa050340.60860519
97Hematopoietic cell lineage_Homo sapiens_hsa046400.60832847
98Chronic myeloid leukemia_Homo sapiens_hsa052200.57360683
99HTLV-I infection_Homo sapiens_hsa051660.57306817
100Epstein-Barr virus infection_Homo sapiens_hsa051690.57000816
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56144292
102Pancreatic cancer_Homo sapiens_hsa052120.54866378
103Platelet activation_Homo sapiens_hsa046110.54831303
104Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54712987
105Butanoate metabolism_Homo sapiens_hsa006500.53734600
106PPAR signaling pathway_Homo sapiens_hsa033200.53499828
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51938682
108Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51908710
109Phototransduction_Homo sapiens_hsa047440.51459161
110Viral carcinogenesis_Homo sapiens_hsa052030.50841290
111Bile secretion_Homo sapiens_hsa049760.49884827
112Type I diabetes mellitus_Homo sapiens_hsa049400.48918344
113Acute myeloid leukemia_Homo sapiens_hsa052210.48665902
114FoxO signaling pathway_Homo sapiens_hsa040680.48569370
115Prolactin signaling pathway_Homo sapiens_hsa049170.48473244
116Viral myocarditis_Homo sapiens_hsa054160.48376686
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47867924
118Fatty acid biosynthesis_Homo sapiens_hsa000610.47738145
119Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47594814
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47053572
121Collecting duct acid secretion_Homo sapiens_hsa049660.45646982
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45486587
123Insulin signaling pathway_Homo sapiens_hsa049100.43478798
124Glucagon signaling pathway_Homo sapiens_hsa049220.42465527
125Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42352404
126mRNA surveillance pathway_Homo sapiens_hsa030150.42160902
127Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42061542

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