DST

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the plakin protein family of adhesion junction plaque proteins. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the full-length nature of some variants has not been defined. It has been reported that some isoforms are expressed in neural and muscle tissue, anchoring neural intermediate filaments to the actin cytoskeleton, and some isoforms are expressed in epithelial tissue, anchoring keratin-containing intermediate filaments to hemidesmosomes. Consistent with the expression, mice defective for this gene show skin blistering and neurodegeneration. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.95743689
2plasma membrane repair (GO:0001778)3.94483573
3regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.80022257
4regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.58117982
5cell communication by electrical coupling (GO:0010644)3.52312159
6desmosome organization (GO:0002934)3.49135355
7positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.39631328
8cell communication involved in cardiac conduction (GO:0086065)3.36416176
9regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.32460367
10regulation of short-term neuronal synaptic plasticity (GO:0048172)3.30974560
11membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.28233993
12synaptic vesicle maturation (GO:0016188)3.14638829
13locomotory exploration behavior (GO:0035641)3.14380884
14regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.13716242
15cytoskeletal anchoring at plasma membrane (GO:0007016)3.13528105
16embryonic retina morphogenesis in camera-type eye (GO:0060059)2.99960378
17establishment of nucleus localization (GO:0040023)2.91431687
18regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.90334145
19presynaptic membrane assembly (GO:0097105)2.83842793
20cerebellar Purkinje cell differentiation (GO:0021702)2.83500185
21positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.80498935
22positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.79787890
23presynaptic membrane organization (GO:0097090)2.77540406
24sodium ion export (GO:0071436)2.76718788
25axon ensheathment in central nervous system (GO:0032291)2.76278032
26central nervous system myelination (GO:0022010)2.76278032
27protein targeting to Golgi (GO:0000042)2.75071206
28negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.73174319
29neuronal action potential propagation (GO:0019227)2.72610980
30dendrite morphogenesis (GO:0048813)2.71912321
31* hemidesmosome assembly (GO:0031581)2.71777197
32negative regulation of keratinocyte proliferation (GO:0010839)2.71035684
33positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.70323972
34positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.69604031
35sarcoplasmic reticulum calcium ion transport (GO:0070296)2.69520239
36negative regulation of potassium ion transmembrane transport (GO:1901380)2.67739012
37cell adhesion mediated by integrin (GO:0033627)2.67627298
38axonal fasciculation (GO:0007413)2.67202787
39cellular potassium ion homeostasis (GO:0030007)2.66009492
40nucleus localization (GO:0051647)2.66001202
41cell migration in hindbrain (GO:0021535)2.63993052
42membrane depolarization during action potential (GO:0086010)2.63627583
43regulation of membrane repolarization (GO:0060306)2.63073868
44cardiac myofibril assembly (GO:0055003)2.60037225
45peripheral nervous system axon ensheathment (GO:0032292)2.58979386
46myelination in peripheral nervous system (GO:0022011)2.58979386
47establishment of protein localization to Golgi (GO:0072600)2.58815923
48regulation of cell communication by electrical coupling (GO:0010649)2.58499394
49retrograde transport, vesicle recycling within Golgi (GO:0000301)2.57775569
50regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.55557065
51bundle of His cell to Purkinje myocyte communication (GO:0086069)2.53906348
52potassium ion import (GO:0010107)2.53390188
53regulation of calcium ion transmembrane transporter activity (GO:1901019)2.53059511
54regulation of calcium ion transmembrane transport (GO:1903169)2.53059511
55activation of protein kinase A activity (GO:0034199)2.53037604
56neuron recognition (GO:0008038)2.52758679
57vocalization behavior (GO:0071625)2.52020096
58regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.49608514
59layer formation in cerebral cortex (GO:0021819)2.49073047
60smooth muscle tissue development (GO:0048745)2.47665394
61neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.45918929
62detection of calcium ion (GO:0005513)2.44234787
63relaxation of cardiac muscle (GO:0055119)2.43266418
64regulation of axon guidance (GO:1902667)2.42733775
65regulation of transforming growth factor beta2 production (GO:0032909)2.42635739
66astrocyte development (GO:0014002)2.42054425
67positive regulation of potassium ion transmembrane transport (GO:1901381)2.41701986
68* cell-substrate junction assembly (GO:0007044)2.38785257
69neuromuscular junction development (GO:0007528)2.38486678
70positive regulation of potassium ion transport (GO:0043268)2.37043973
71paraxial mesoderm development (GO:0048339)2.36010887
72ventricular cardiac muscle cell action potential (GO:0086005)2.35381774
73vesicle transport along microtubule (GO:0047496)2.34129378
74macroautophagy (GO:0016236)2.33580081
75neuronal ion channel clustering (GO:0045161)2.33427463
76lymphangiogenesis (GO:0001946)2.31252626
77cardiac conduction (GO:0061337)2.30929416
78dendritic spine morphogenesis (GO:0060997)2.30001709
79synaptic vesicle docking involved in exocytosis (GO:0016081)2.29255444
80insulin-like growth factor receptor signaling pathway (GO:0048009)2.29102762
81myofibril assembly (GO:0030239)2.28904479
82positive regulation of glycogen metabolic process (GO:0070875)2.28560549
83regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.28100523
84myelination (GO:0042552)2.27241794
85nerve growth factor signaling pathway (GO:0038180)2.26057558
86sarcomere organization (GO:0045214)2.26004698
87negative regulation of protein localization to cell surface (GO:2000009)2.25253808
88proline transport (GO:0015824)2.24866447
89potassium ion homeostasis (GO:0055075)2.24649327
90cardiac muscle contraction (GO:0060048)2.24398519
91positive regulation of cation channel activity (GO:2001259)2.23859117
92cardiac muscle cell action potential (GO:0086001)2.21830230
93regulation of heart rate by cardiac conduction (GO:0086091)2.21771989
94regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.21144503
95glutamate secretion (GO:0014047)2.20531120
96retina vasculature morphogenesis in camera-type eye (GO:0061299)2.20372321
97axon ensheathment (GO:0008366)2.19779421
98ensheathment of neurons (GO:0007272)2.19779421
99neuromuscular process controlling balance (GO:0050885)2.19763271
100carnitine shuttle (GO:0006853)2.19367989
101positive regulation of cardiac muscle hypertrophy (GO:0010613)2.18709115
102positive regulation of muscle hypertrophy (GO:0014742)2.18709115
103negative regulation of axon extension involved in axon guidance (GO:0048843)2.18569723
104central nervous system projection neuron axonogenesis (GO:0021952)2.16901458
105Golgi to plasma membrane protein transport (GO:0043001)2.16884643
106organelle transport along microtubule (GO:0072384)2.16869160
107cytoplasmic mRNA processing body assembly (GO:0033962)2.16442195
108regulation of synaptic vesicle exocytosis (GO:2000300)2.16230900
109regulation of actin filament-based movement (GO:1903115)2.15589074
110apical protein localization (GO:0045176)2.15305355
111skin morphogenesis (GO:0043589)2.15115368
112innervation (GO:0060384)2.14947971
113negative regulation of cytosolic calcium ion concentration (GO:0051481)2.14247854
114phospholipid translocation (GO:0045332)2.14066645
115lipid translocation (GO:0034204)2.14066645
116regulation of axon extension involved in axon guidance (GO:0048841)2.13936759
117morphogenesis of an epithelial sheet (GO:0002011)2.13139849
118hippo signaling (GO:0035329)2.12561639
119regulation of ARF protein signal transduction (GO:0032012)2.12484889
120axon extension (GO:0048675)2.12007532
121interkinetic nuclear migration (GO:0022027)2.11806024
122negative regulation of neurotransmitter secretion (GO:0046929)2.11398169
123gamma-aminobutyric acid transport (GO:0015812)2.11334710
124membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.11121078
125peptidyl-tyrosine autophosphorylation (GO:0038083)2.11079742
126ionotropic glutamate receptor signaling pathway (GO:0035235)2.11077647
127regulation of cardiac muscle contraction (GO:0055117)2.10455652
128chemosensory behavior (GO:0007635)2.10287614
129postsynaptic membrane organization (GO:0001941)2.10209821
130chondrocyte proliferation (GO:0035988)2.09953148
131suckling behavior (GO:0001967)2.09911345
132myoblast fusion (GO:0007520)2.09755071
133regulation of glutamate receptor signaling pathway (GO:1900449)2.09655247
134regulation of cardiac muscle cell contraction (GO:0086004)2.08899780
135pericardium development (GO:0060039)2.08497442
136glycine transport (GO:0015816)2.08054711
137cardiac muscle cell action potential involved in contraction (GO:0086002)2.07990224
138regulation of synapse structural plasticity (GO:0051823)2.07276041
139cerebellar granule cell differentiation (GO:0021707)2.07223669
140collagen fibril organization (GO:0030199)2.07049440
141membrane assembly (GO:0071709)2.06169393
142regulation of potassium ion transmembrane transporter activity (GO:1901016)2.05972547
143regulation of potassium ion transmembrane transport (GO:1901379)2.05952740
144regulation of p38MAPK cascade (GO:1900744)2.05944838
145protein localization to cell surface (GO:0034394)2.05680202
146asymmetric protein localization (GO:0008105)2.05012615
147negative chemotaxis (GO:0050919)2.04264903
148long-chain fatty acid biosynthetic process (GO:0042759)2.04234742
149embryonic foregut morphogenesis (GO:0048617)2.03526104
150central nervous system neuron axonogenesis (GO:0021955)2.02736303
151neurotransmitter-gated ion channel clustering (GO:0072578)2.01728361
152regulation of skeletal muscle cell differentiation (GO:2001014)2.00991576
153myotube differentiation (GO:0014902)2.00195176
154sequestering of extracellular ligand from receptor (GO:0035581)1.99779182
155regulation of keratinocyte proliferation (GO:0010837)1.98210572
156positive regulation of neurological system process (GO:0031646)1.96538049
157Golgi to plasma membrane transport (GO:0006893)1.94864269
158peripheral nervous system development (GO:0007422)1.94193700
159artery development (GO:0060840)1.93069280
160regulation of pigment cell differentiation (GO:0050932)1.92148514
161amino acid import (GO:0043090)1.91991341
162fibroblast migration (GO:0010761)1.91755832

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.68227493
2GBX2_23144817_ChIP-Seq_PC3_Human2.85324199
3DROSHA_22980978_ChIP-Seq_HELA_Human2.21308830
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.17268130
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.05753513
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.99152066
7RNF2_18974828_ChIP-Seq_MESCs_Mouse1.98953950
8EZH2_18974828_ChIP-Seq_MESCs_Mouse1.98953950
9JARID2_20064375_ChIP-Seq_MESCs_Mouse1.93401336
10CDX2_19796622_ChIP-Seq_MESCs_Mouse1.91834579
11ZNF217_24962896_ChIP-Seq_MCF-7_Human1.84804429
12EP300_21415370_ChIP-Seq_HL-1_Mouse1.83964208
13AR_21572438_ChIP-Seq_LNCaP_Human1.83933531
14* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.83206667
15MTF2_20144788_ChIP-Seq_MESCs_Mouse1.80050984
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.77185150
17JARID2_20075857_ChIP-Seq_MESCs_Mouse1.71702101
18EZH2_27304074_Chip-Seq_ESCs_Mouse1.71047762
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.69629758
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.69214890
21RBPJ_22232070_ChIP-Seq_NCS_Mouse1.68023296
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.67563697
23* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.66250614
24* TP63_17297297_ChIP-ChIP_HaCaT_Human1.62674303
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.61454993
26* AHR_22903824_ChIP-Seq_MCF-7_Human1.61281639
27* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.60569379
28PIAS1_25552417_ChIP-Seq_VCAP_Human1.59521250
29TP53_16413492_ChIP-PET_HCT116_Human1.58646883
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.58511110
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.56820573
32* SMAD4_21799915_ChIP-Seq_A2780_Human1.54250837
33* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.52996721
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.52833150
35EZH2_27294783_Chip-Seq_ESCs_Mouse1.51045309
36* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51006898
37* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47723215
38TRIM28_21343339_ChIP-Seq_HEK293_Human1.45203356
39* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44353195
40CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.42739711
41FUS_26573619_Chip-Seq_HEK293_Human1.40825226
42CTNNB1_20460455_ChIP-Seq_HCT116_Human1.40807033
43AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40499134
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.40121442
45* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.39417978
46* ARNT_22903824_ChIP-Seq_MCF-7_Human1.38834046
47BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.38807260
48TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.38486284
49SUZ12_27294783_Chip-Seq_ESCs_Mouse1.36575029
50* STAT3_23295773_ChIP-Seq_U87_Human1.35703175
51ESR1_20079471_ChIP-ChIP_T-47D_Human1.35171246
52* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35102729
53* RARB_27405468_Chip-Seq_BRAIN_Mouse1.32257341
54ESR2_21235772_ChIP-Seq_MCF-7_Human1.29977294
55* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.29849495
56* BRD4_25478319_ChIP-Seq_HGPS_Human1.28833674
57SOX2_21211035_ChIP-Seq_LN229_Gbm1.27491847
58RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27382254
59* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26822904
60WT1_19549856_ChIP-ChIP_CCG9911_Human1.26277605
61TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25625009
62* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.25439523
63* NANOG_18555785_Chip-Seq_ESCs_Mouse1.25149007
64* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.24216336
65EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.24012532
66STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.23033504
67* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.22551395
68NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21207049
69AR_19668381_ChIP-Seq_PC3_Human1.18854133
70WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18654440
71RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.18528524
72REST_21632747_ChIP-Seq_MESCs_Mouse1.17951146
73KDM2B_26808549_Chip-Seq_K562_Human1.17503902
74* SMAD3_21741376_ChIP-Seq_EPCs_Human1.16565555
75TCF4_18268006_ChIP-ChIP_LS174T_Human1.16502459
76SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16110970
77* TCF4_23295773_ChIP-Seq_U87_Human1.13889107
78ZNF274_21170338_ChIP-Seq_K562_Hela1.13320751
79CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12769844
80* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12151941
81* SMAD4_21741376_ChIP-Seq_HESCs_Human1.10152131
82OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09933337
83TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09858461
84* SMAD3_21741376_ChIP-Seq_HESCs_Human1.09725842
85* TP63_23658742_ChIP-Seq_EP156T_Human1.09633357
86LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09532827
87VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.09255016
88* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08764018
89BCAT_22108803_ChIP-Seq_LS180_Human1.08184477
90TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08006154
91KDM2B_26808549_Chip-Seq_REH_Human1.07435676
92NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07166857
93* ISL1_27105846_Chip-Seq_CPCs_Mouse1.05543923
94NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.05374803
95* E2F1_18555785_Chip-Seq_ESCs_Mouse1.05117415
96CTBP1_25329375_ChIP-Seq_LNCAP_Human1.05077618
97TBX3_20139965_ChIP-Seq_ESCs_Mouse1.04814908
98TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04510851
99* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03897845
100NRF2_20460467_ChIP-Seq_MEFs_Mouse1.03145170
101NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.03145170
102TP53_18474530_ChIP-ChIP_U2OS_Human1.03085207
103* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01737827
104SOX9_26525672_Chip-Seq_HEART_Mouse1.01547311
105* FOXA2_19822575_ChIP-Seq_HepG2_Human1.00867534
106* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00714505
107TAF15_26573619_Chip-Seq_HEK293_Human1.00424387
108ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99869292
109DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.99515387
110SALL1_21062744_ChIP-ChIP_HESCs_Human0.99470490
111* RXR_22108803_ChIP-Seq_LS180_Human0.98517579
112PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.97236982
113RING1B_27294783_Chip-Seq_ESCs_Mouse0.96719916
114PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96228750
115RING1B_27294783_Chip-Seq_NPCs_Mouse0.95604821
116TBX20_22328084_ChIP-Seq_HEART_Mouse0.95474167
117TBX20_22080862_ChIP-Seq_HEART_Mouse0.95474167
118* AR_25329375_ChIP-Seq_VCAP_Human0.94174445
119P300_19829295_ChIP-Seq_ESCs_Human0.94101407
120* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93728825
121FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.92449358
122CJUN_26792858_Chip-Seq_BT549_Human0.92408612
123ESR1_21235772_ChIP-Seq_MCF-7_Human0.92246703
124TBX3_20139965_ChIP-Seq_MESCs_Mouse0.91223112
125TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90647496
126PPAR_26484153_Chip-Seq_NCI-H1993_Human0.90611110
127ZFP57_27257070_Chip-Seq_ESCs_Mouse0.90193839

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000751_myopathy3.31224199
2MP0002837_dystrophic_cardiac_calcinosis2.92407669
3MP0004859_abnormal_synaptic_plasticity2.89583740
4MP0004270_analgesia2.80472627
5MP0009780_abnormal_chondrocyte_physiolo2.55337092
6MP0004145_abnormal_muscle_electrophysio2.40564121
7MP0004215_abnormal_myocardial_fiber2.24806316
8MP0003941_abnormal_skin_development2.15540685
9MP0000749_muscle_degeneration2.12163590
10MP0004272_abnormal_basement_membrane2.01785213
11MP0004084_abnormal_cardiac_muscle1.99669602
12MP0010352_gastrointestinal_tract_polyps1.98918647
13MP0005623_abnormal_meninges_morphology1.93835365
14MP0003635_abnormal_synaptic_transmissio1.90003465
15MP0008438_abnormal_cutaneous_collagen1.84192574
16* MP0009046_muscle_twitch1.80797877
17MP0004858_abnormal_nervous_system1.76986101
18* MP0003045_fibrosis1.76108297
19* MP0001299_abnormal_eye_distance/1.68883891
20MP0001958_emphysema1.67885211
21MP0003283_abnormal_digestive_organ1.67356307
22MP0010368_abnormal_lymphatic_system1.63749921
23MP0004130_abnormal_muscle_cell1.62935619
24MP0005275_abnormal_skin_tensile1.59228293
25MP0004036_abnormal_muscle_relaxation1.58113284
26MP0000569_abnormal_digit_pigmentation1.57428783
27MP0003705_abnormal_hypodermis_morpholog1.56069987
28MP0000383_abnormal_hair_follicle1.55989281
29MP0000762_abnormal_tongue_morphology1.53970156
30MP0005171_absent_coat_pigmentation1.52798805
31* MP0004087_abnormal_muscle_fiber1.52160212
32MP0003137_abnormal_impulse_conducting1.50168686
33MP0005187_abnormal_penis_morphology1.49922167
34MP0002909_abnormal_adrenal_gland1.49242695
35MP0005257_abnormal_intraocular_pressure1.49059592
36MP0005670_abnormal_white_adipose1.48173023
37MP0010678_abnormal_skin_adnexa1.47398689
38MP0003646_muscle_fatigue1.46786193
39MP0005330_cardiomyopathy1.46296633
40MP0000013_abnormal_adipose_tissue1.46171323
41MP0002108_abnormal_muscle_morphology1.45998411
42MP0000747_muscle_weakness1.43694427
43* MP0002734_abnormal_mechanical_nocicepti1.43366048
44MP0002272_abnormal_nervous_system1.41888194
45MP0004233_abnormal_muscle_weight1.39002558
46MP0001984_abnormal_olfaction1.38358761
47MP0005620_abnormal_muscle_contractility1.37879028
48MP0004484_altered_response_of1.36111008
49MP0009745_abnormal_behavioral_response1.34506421
50MP0006138_congestive_heart_failure1.34090062
51MP0000579_abnormal_nail_morphology1.34005534
52* MP0001486_abnormal_startle_reflex1.32386384
53MP0002972_abnormal_cardiac_muscle1.32369027
54MP0003950_abnormal_plasma_membrane1.30964761
55MP0005666_abnormal_adipose_tissue1.29515549
56MP0008775_abnormal_heart_ventricle1.28942800
57MP0000462_abnormal_digestive_system1.27651017
58MP0008569_lethality_at_weaning1.26477500
59MP0004085_abnormal_heartbeat1.25647817
60* MP0002064_seizures1.24293890
61* MP0002269_muscular_atrophy1.23576214
62MP0004885_abnormal_endolymph1.22708026
63* MP0000759_abnormal_skeletal_muscle1.22221066
64MP0005248_abnormal_Harderian_gland1.21859036
65MP0005375_adipose_tissue_phenotype1.20566795
66MP0000003_abnormal_adipose_tissue1.19555042
67MP0001968_abnormal_touch/_nociception1.19485217
68MP0000566_synostosis1.19168209
69MP0003385_abnormal_body_wall1.18723582
70MP0002063_abnormal_learning/memory/cond1.18717743
71MP0003868_abnormal_feces_composition1.18665421
72MP0010234_abnormal_vibrissa_follicle1.18598021
73MP0000778_abnormal_nervous_system1.18480616
74MP0002060_abnormal_skin_morphology1.17049210
75MP0000750_abnormal_muscle_regeneration1.12681394
76MP0002184_abnormal_innervation1.10471534
77MP0005369_muscle_phenotype1.09689893
78MP0002106_abnormal_muscle_physiology1.09034593
79MP0000955_abnormal_spinal_cord1.08214547
80* MP0002067_abnormal_sensory_capabilities1.07903513
81MP0003937_abnormal_limbs/digits/tail_de1.07305161
82MP0010630_abnormal_cardiac_muscle1.06323575
83MP0002572_abnormal_emotion/affect_behav1.05562102
84MP0003091_abnormal_cell_migration1.03653792
85MP0002733_abnormal_thermal_nociception1.03038931
86MP0003880_abnormal_central_pattern1.02987890
87* MP0005023_abnormal_wound_healing1.02946845
88MP0000537_abnormal_urethra_morphology1.02039601
89MP0002735_abnormal_chemical_nociception0.99824024
90MP0001970_abnormal_pain_threshold0.99254165
91MP0004134_abnormal_chest_morphology0.99179315
92MP0000427_abnormal_hair_cycle0.98655221
93MP0005409_darkened_coat_color0.98406177
94MP0009384_cardiac_valve_regurgitation0.98393035
95MP0001440_abnormal_grooming_behavior0.97376639
96MP0001879_abnormal_lymphatic_vessel0.97367991
97MP0003634_abnormal_glial_cell0.96694691
98MP0001177_atelectasis0.96462713
99MP0002896_abnormal_bone_mineralization0.96184905
100MP0010386_abnormal_urinary_bladder0.95778275
101* MP0000920_abnormal_myelination0.94768593
102MP0003935_abnormal_craniofacial_develop0.93846142
103MP0000733_abnormal_muscle_development0.93132321
104MP0003755_abnormal_palate_morphology0.92153437
105MP0005503_abnormal_tendon_morphology0.91777559
106MP0004924_abnormal_behavior0.91554394
107MP0005386_behavior/neurological_phenoty0.91554394
108MP0000534_abnormal_ureter_morphology0.91468441
109MP0002697_abnormal_eye_size0.91026606
110MP0006054_spinal_hemorrhage0.89874674
111MP0005423_abnormal_somatic_nervous0.89732768
112MP0004185_abnormal_adipocyte_glucose0.88756622
113MP0003890_abnormal_embryonic-extraembry0.88599122
114MP0001501_abnormal_sleep_pattern0.88292115
115MP0003279_aneurysm0.88155002
116MP0005385_cardiovascular_system_phenoty0.86899682
117MP0001544_abnormal_cardiovascular_syste0.86899682
118MP0002234_abnormal_pharynx_morphology0.86241703
119* MP0002882_abnormal_neuron_morphology0.85834236
120MP0000647_abnormal_sebaceous_gland0.85738267
121MP0003690_abnormal_glial_cell0.85245141
122MP0002877_abnormal_melanocyte_morpholog0.82406972
123MP0000428_abnormal_craniofacial_morphol0.81964188
124MP0003566_abnormal_cell_adhesion0.81255746
125* MP0004811_abnormal_neuron_physiology0.79733788
126MP0002233_abnormal_nose_morphology0.79711737
127MP0000467_abnormal_esophagus_morphology0.78254370
128MP0002332_abnormal_exercise_endurance0.78100688
129MP0003136_yellow_coat_color0.77804930
130MP0002557_abnormal_social/conspecific_i0.77120996
131MP0000432_abnormal_head_morphology0.75018167
132* MP0002168_other_aberrant_phenotype0.74909911
133* MP0003632_abnormal_nervous_system0.74676553
134MP0008961_abnormal_basal_metabolism0.74455457
135* MP0003633_abnormal_nervous_system0.74290130
136MP0002254_reproductive_system_inflammat0.73850700
137MP0000767_abnormal_smooth_muscle0.73302333
138MP0002295_abnormal_pulmonary_circulatio0.72715099
139MP0009250_abnormal_appendicular_skeleto0.72034959
140MP0002177_abnormal_outer_ear0.68946532
141MP0003942_abnormal_urinary_system0.68332223

Predicted human phenotypes

RankGene SetZ-score
1Hyporeflexia of lower limbs (HP:0002600)3.81524192
2Sudden death (HP:0001699)3.78737275
3Action tremor (HP:0002345)3.72567986
4Difficulty running (HP:0009046)3.23894220
5Increased connective tissue (HP:0009025)3.03811900
6Muscle fiber splitting (HP:0003555)2.92941428
7Prolonged QT interval (HP:0001657)2.86616117
8Atrial fibrillation (HP:0005110)2.85405729
9Right ventricular cardiomyopathy (HP:0011663)2.80262770
10Alopecia of scalp (HP:0002293)2.79404623
11Abnormality of the calf musculature (HP:0001430)2.73721287
12Broad metatarsal (HP:0001783)2.71718950
13Focal motor seizures (HP:0011153)2.68484042
14Focal seizures (HP:0007359)2.65334809
15Primary atrial arrhythmia (HP:0001692)2.63222722
16Syncope (HP:0001279)2.61136920
17Shallow orbits (HP:0000586)2.60579327
18Arterial tortuosity (HP:0005116)2.57803014
19Calf muscle hypertrophy (HP:0008981)2.56796289
20Cerebral aneurysm (HP:0004944)2.55500387
21Macroorchidism (HP:0000053)2.47729204
22Vascular tortuosity (HP:0004948)2.47066385
23Muscle hypertrophy of the lower extremities (HP:0008968)2.47039397
24Thick nail (HP:0001805)2.45765447
25Papillary thyroid carcinoma (HP:0002895)2.45398494
26Abnormality of the ischium (HP:0003174)2.44697550
27Aortic aneurysm (HP:0004942)2.42192408
28Lower limb amyotrophy (HP:0007210)2.40159053
29Dysmetric saccades (HP:0000641)2.39195814
30Supraventricular arrhythmia (HP:0005115)2.38554786
31Supraventricular tachycardia (HP:0004755)2.38277181
32Neonatal short-limb short stature (HP:0008921)2.38254134
33Bundle branch block (HP:0011710)2.38166858
34Hypoplastic ischia (HP:0003175)2.38160793
35Insidious onset (HP:0003587)2.37929681
36Termporal pattern (HP:0011008)2.37929681
37Ulnar claw (HP:0001178)2.37837960
38Aortic dissection (HP:0002647)2.36419418
39Scapular winging (HP:0003691)2.34713937
40Progressive cerebellar ataxia (HP:0002073)2.34618028
41Protrusio acetabuli (HP:0003179)2.31475211
42Exercise-induced myalgia (HP:0003738)2.29167593
43Myokymia (HP:0002411)2.27459689
44Genetic anticipation (HP:0003743)2.22754415
45Myotonia (HP:0002486)2.19252460
46Increased variability in muscle fiber diameter (HP:0003557)2.16689600
47Urethral obstruction (HP:0000796)2.15013643
48Gaze-evoked nystagmus (HP:0000640)2.14825173
49Ventricular tachycardia (HP:0004756)2.13234724
50Hypoplastic labia majora (HP:0000059)2.11980417
51Urinary bladder sphincter dysfunction (HP:0002839)2.11452010
52Hyperventilation (HP:0002883)2.11281711
53Vertebral arch anomaly (HP:0008438)2.10889126
54Aplasia involving bones of the upper limbs (HP:0009823)2.10464332
55Aplasia of the phalanges of the hand (HP:0009802)2.10464332
56Aplasia involving bones of the extremities (HP:0009825)2.10464332
57Ventricular fibrillation (HP:0001663)2.09813456
58Mildly elevated creatine phosphokinase (HP:0008180)2.09315092
59Cutaneous finger syndactyly (HP:0010554)2.08714685
60Onion bulb formation (HP:0003383)2.08543549
61Distal lower limb amyotrophy (HP:0008944)2.08256794
62Scanning speech (HP:0002168)2.08242035
63Steppage gait (HP:0003376)2.07457878
64Dysdiadochokinesis (HP:0002075)2.05546503
65Hammertoe (HP:0001765)2.04895503
66Decreased motor nerve conduction velocity (HP:0003431)2.04388787
67EMG: myopathic abnormalities (HP:0003458)2.04332847
68Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.03823677
69Aqueductal stenosis (HP:0002410)2.02161628
70Ventricular arrhythmia (HP:0004308)2.00255943
71Plantar hyperkeratosis (HP:0007556)1.99251566
72Febrile seizures (HP:0002373)1.99050793
73Abnormality of the labia majora (HP:0012881)1.98023801
74Foot dorsiflexor weakness (HP:0009027)1.97515871
75Overgrowth (HP:0001548)1.95373760
76Natal tooth (HP:0000695)1.92368939
77Proximal amyotrophy (HP:0007126)1.92290573
78Abnormal EKG (HP:0003115)1.92173111
79Fragile skin (HP:0001030)1.92073565
80Abnormality of nail color (HP:0100643)1.91625227
81Insulin-resistant diabetes mellitus (HP:0000831)1.91248806
82Difficulty climbing stairs (HP:0003551)1.91059282
83Laryngomalacia (HP:0001601)1.90610327
84Bronchomalacia (HP:0002780)1.89532445
85Type 1 muscle fiber predominance (HP:0003803)1.89217282
86Milia (HP:0001056)1.89184507
87Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.88306212
88Premature rupture of membranes (HP:0001788)1.87407257
89Abnormality of the foot musculature (HP:0001436)1.85014606
90Hepatoblastoma (HP:0002884)1.84265581
91Neurofibrillary tangles (HP:0002185)1.83439269
92* Limited hip movement (HP:0008800)1.83290374
93Wide anterior fontanel (HP:0000260)1.82514502
94Truncal ataxia (HP:0002078)1.81155447
95Dysmetria (HP:0001310)1.80795728
96Cutaneous syndactyly (HP:0012725)1.80619761
97Atonic seizures (HP:0010819)1.80402923
98Drooling (HP:0002307)1.80342022
99Coronal craniosynostosis (HP:0004440)1.79644364
100Lipoatrophy (HP:0100578)1.79380876
101Postural instability (HP:0002172)1.79091931
102Mitral stenosis (HP:0001718)1.77256206
103Blue irides (HP:0000635)1.76686605
104Onycholysis (HP:0001806)1.76301290
105Turricephaly (HP:0000262)1.76223626
106Pulmonic stenosis (HP:0001642)1.74583127
107Abnormality of the nasal septum (HP:0000419)1.74342802
108Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.74068479
109Aneurysm (HP:0002617)1.73518428
110Broad-based gait (HP:0002136)1.71579770
111Popliteal pterygium (HP:0009756)1.71532091
112Hip contracture (HP:0003273)1.70756358
113Abnormal atrioventricular conduction (HP:0005150)1.70535180
114Wormian bones (HP:0002645)1.69551602
115Abnormality of skeletal muscle fiber size (HP:0012084)1.69505613
116Lower limb muscle weakness (HP:0007340)1.69133337
117Intention tremor (HP:0002080)1.68954159
118Heterotopia (HP:0002282)1.68701723
119Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.68609480
120Cubitus valgus (HP:0002967)1.67712149
121Abnormality of the corticospinal tract (HP:0002492)1.67643071
122* Atrophic scars (HP:0001075)1.67443642
123Subaortic stenosis (HP:0001682)1.67335020
124Abnormality of the left ventricular outflow tract (HP:0011103)1.67335020
125Ulnar bowing (HP:0003031)1.67241632
126Agitation (HP:0000713)1.66910465
127Palmar hyperkeratosis (HP:0010765)1.66474575
128Bladder diverticulum (HP:0000015)1.65759620
129Supranuclear gaze palsy (HP:0000605)1.65660823
130Hemiplegia (HP:0002301)1.65395907
131Heart block (HP:0012722)1.65378768
132Palmoplantar hyperkeratosis (HP:0000972)1.64961095
133Hypoplasia of the iris (HP:0007676)1.64433118
134Absent frontal sinuses (HP:0002688)1.63936620
135Pheochromocytoma (HP:0002666)1.63704899
136Advanced eruption of teeth (HP:0006288)1.63530692
137Abnormal sex determination (HP:0012244)1.63226492
138Sex reversal (HP:0012245)1.63226492
139Exercise-induced muscle cramps (HP:0003710)1.62980914
140Hypoventilation (HP:0002791)1.62452582
141Hypoplasia of dental enamel (HP:0006297)1.60613497
142Follicular hyperkeratosis (HP:0007502)1.60270099
143Fair hair (HP:0002286)1.59382992
144Osteolytic defects of the hand bones (HP:0009699)1.59337188
145Osteolytic defects of the phalanges of the hand (HP:0009771)1.59337188
146Knee flexion contracture (HP:0006380)1.58473022
147Fatigable weakness (HP:0003473)1.56876263
148Abnormality of the neuromuscular junction (HP:0003398)1.56876263
149Mitral valve prolapse (HP:0001634)1.56372273
150Tibial bowing (HP:0002982)1.53133107
151Excessive salivation (HP:0003781)1.52486961
152Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.51921033
153Abnormality of the astrocytes (HP:0100707)1.51007916
154Astrocytoma (HP:0009592)1.51007916
155Abnormal auditory evoked potentials (HP:0006958)1.50208970
156Abnormality of the epiphyses of the hand (HP:0005924)1.47828733
157Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.46711272
158Abnormality of secondary sexual hair (HP:0009888)1.45312043
159Abnormality of the axillary hair (HP:0100134)1.45312043
160Mild short stature (HP:0003502)1.45034708
161Bell-shaped thorax (HP:0001591)1.45014442
162Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.43854474
163Tracheomalacia (HP:0002779)1.43559274

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK32.65095303
2PHKG22.61476304
3PHKG12.61476304
4AKT32.59498020
5INSRR2.23722221
6CAMK1G2.17593996
7TTN2.08480320
8CAMK1D1.99557760
9CASK1.94909351
10LATS11.91211779
11LMTK21.86930455
12OBSCN1.86604709
13DMPK1.83733047
14NTRK11.83043671
15WNK11.81489969
16MAP3K41.80413895
17RIPK11.75330567
18MST1R1.75328558
19TNIK1.65456649
20STK38L1.63709788
21MAP3K91.61803557
22PRKD31.60741823
23PAK61.55721348
24FGFR21.51827387
25PDGFRA1.46058898
26STK381.45777232
27FER1.41717328
28SIK11.37242957
29TRPM71.34574070
30MYLK1.21817025
31RET1.21546639
32DDR21.20619543
33CDC42BPA1.20238279
34LATS21.20106087
35EPHA41.17563400
36MAP3K21.14994314
37MARK11.12777034
38MARK21.12352485
39MAP2K41.11752013
40MAP3K11.11658998
41MET1.10265870
42MINK11.09435630
43PAK31.07335481
44ICK1.06163147
45PRKCH1.04868080
46SGK31.04768629
47EPHB11.04379803
48ERBB31.04067592
49NTRK21.03505269
50STK391.01452836
51SGK4941.00553113
52SGK2231.00553113
53WNK40.99050961
54NEK90.98931928
55SGK20.97436487
56MAP3K70.96758205
57CDK120.95135329
58PIK3CA0.93702993
59CAMK2D0.89778337
60CDK50.88978235
61BMPR1B0.88977449
62PBK0.88527359
63PAK20.87997997
64MTOR0.84363262
65CAMK2B0.84311977
66PRKD10.83714098
67DAPK20.83442989
68STK110.83245132
69KSR20.81814817
70PDGFRB0.81252977
71PTK20.81094386
72ROCK10.80285838
73UHMK10.78148648
74PNCK0.76895700
75PLK20.76105500
76MKNK20.75863847
77CAMKK10.74901380
78PRKAA10.74294364
79CSNK1A1L0.74126431
80STK30.73133874
81PKN10.72025882
82SGK10.71790849
83TYRO30.71414921
84TRIB30.70263697
85PRKAA20.69855136
86TGFBR10.69529264
87MAP2K70.67761046
88CAMK40.66374695
89CAMK2A0.66240274
90ERBB40.66052460
91MAPK100.65491984
92ERBB20.64337310
93CAMK2G0.63643938
94CAMK10.63643177
95BMX0.63640515
96EPHA20.63340171
97CAMKK20.62845896
98MAPK130.62408476
99MAP3K60.62095301
100STK240.61854714
101FRK0.61247399
102PRKCE0.60672632
103CSNK1G10.60025729
104BRD40.59997357
105KSR10.59248455
106CSNK1G20.58310782
107RPS6KA30.55654010
108ACVR1B0.54450921
109EPHB20.54360856
110MUSK0.54035195
111ALK0.53641562
112ROCK20.51831174
113PDPK10.51504249
114PINK10.51014258
115PRKD20.50920609
116FGFR10.50625148
117FGFR30.49817828
118PDK30.47716549
119PDK40.47716549
120EPHA30.47499316
121BCR0.47403435
122PRKCG0.46459076
123NEK60.46262826
124OXSR10.46130919
125JAK10.45684695
126PTK60.45035284
127CSNK1D0.44291578
128PRKG10.44251581

Predicted pathways (KEGG)

RankGene SetZ-score
1Dilated cardiomyopathy_Homo sapiens_hsa054142.15041718
2Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.97243095
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.85397399
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.83306528
5Insulin secretion_Homo sapiens_hsa049111.82874742
6Type II diabetes mellitus_Homo sapiens_hsa049301.76706856
7Circadian entrainment_Homo sapiens_hsa047131.74837980
8Nicotine addiction_Homo sapiens_hsa050331.67542401
9Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.66878868
10Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.56503637
11Salivary secretion_Homo sapiens_hsa049701.56352939
12Glutamatergic synapse_Homo sapiens_hsa047241.52940478
13GABAergic synapse_Homo sapiens_hsa047271.52097505
14Dorso-ventral axis formation_Homo sapiens_hsa043201.50858346
15Renin secretion_Homo sapiens_hsa049241.47223351
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.45167806
17Long-term potentiation_Homo sapiens_hsa047201.44348312
18Synaptic vesicle cycle_Homo sapiens_hsa047211.43606307
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.43307173
20Gastric acid secretion_Homo sapiens_hsa049711.41902553
21Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.41285118
22Morphine addiction_Homo sapiens_hsa050321.38656320
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.38601485
24Cholinergic synapse_Homo sapiens_hsa047251.36099450
25Olfactory transduction_Homo sapiens_hsa047401.35129036
26ECM-receptor interaction_Homo sapiens_hsa045121.32803110
27GnRH signaling pathway_Homo sapiens_hsa049121.32060042
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.27990337
29Nitrogen metabolism_Homo sapiens_hsa009101.27458149
30Calcium signaling pathway_Homo sapiens_hsa040201.27437421
31Taste transduction_Homo sapiens_hsa047421.26484684
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.26080963
33Axon guidance_Homo sapiens_hsa043601.25964185
34Dopaminergic synapse_Homo sapiens_hsa047281.24882937
35Amphetamine addiction_Homo sapiens_hsa050311.24217445
36cAMP signaling pathway_Homo sapiens_hsa040241.23286376
37Long-term depression_Homo sapiens_hsa047301.21761836
38Oxytocin signaling pathway_Homo sapiens_hsa049211.21724928
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.17767227
40cGMP-PKG signaling pathway_Homo sapiens_hsa040221.14657594
41Focal adhesion_Homo sapiens_hsa045101.11872771
42Melanogenesis_Homo sapiens_hsa049161.09723619
43Fatty acid biosynthesis_Homo sapiens_hsa000611.09693882
44Glucagon signaling pathway_Homo sapiens_hsa049221.08425770
45Gap junction_Homo sapiens_hsa045401.07569129
46Cocaine addiction_Homo sapiens_hsa050301.07450254
47Estrogen signaling pathway_Homo sapiens_hsa049151.07382891
48Vascular smooth muscle contraction_Homo sapiens_hsa042701.03567828
49MicroRNAs in cancer_Homo sapiens_hsa052061.03391714
50Cardiac muscle contraction_Homo sapiens_hsa042600.99373460
51Insulin signaling pathway_Homo sapiens_hsa049100.98262763
52Adherens junction_Homo sapiens_hsa045200.96773476
53Tight junction_Homo sapiens_hsa045300.96064520
54TGF-beta signaling pathway_Homo sapiens_hsa043500.94554059
55ErbB signaling pathway_Homo sapiens_hsa040120.93404258
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.93078305
57Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92722004
58Serotonergic synapse_Homo sapiens_hsa047260.92343095
59Lysine degradation_Homo sapiens_hsa003100.91933682
60Glioma_Homo sapiens_hsa052140.91232287
61Circadian rhythm_Homo sapiens_hsa047100.87938028
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.87603104
63Insulin resistance_Homo sapiens_hsa049310.87381549
64Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85969333
65Proteoglycans in cancer_Homo sapiens_hsa052050.85903193
66Small cell lung cancer_Homo sapiens_hsa052220.84882079
67Histidine metabolism_Homo sapiens_hsa003400.81320041
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.80368467
69Pancreatic secretion_Homo sapiens_hsa049720.79853836
70AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77682634
71Amoebiasis_Homo sapiens_hsa051460.77206143
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76287066
73Bile secretion_Homo sapiens_hsa049760.75942167
74Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75938957
75Inositol phosphate metabolism_Homo sapiens_hsa005620.75557956
76Thyroid hormone synthesis_Homo sapiens_hsa049180.75073412
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.75026352
78MAPK signaling pathway_Homo sapiens_hsa040100.74262455
79AMPK signaling pathway_Homo sapiens_hsa041520.73674568
80Rap1 signaling pathway_Homo sapiens_hsa040150.73639301
81Ovarian steroidogenesis_Homo sapiens_hsa049130.72897559
82Hedgehog signaling pathway_Homo sapiens_hsa043400.72622633
83mTOR signaling pathway_Homo sapiens_hsa041500.70175393
84Protein digestion and absorption_Homo sapiens_hsa049740.68960772
85Wnt signaling pathway_Homo sapiens_hsa043100.66996899
86Basal cell carcinoma_Homo sapiens_hsa052170.65439465
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.65361225
88Ras signaling pathway_Homo sapiens_hsa040140.64546212
89Pathways in cancer_Homo sapiens_hsa052000.64515755
90Sphingolipid metabolism_Homo sapiens_hsa006000.64377993
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63913401
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63685343
93Hippo signaling pathway_Homo sapiens_hsa043900.63169290
94Choline metabolism in cancer_Homo sapiens_hsa052310.61912420
95Renal cell carcinoma_Homo sapiens_hsa052110.61770318
96Endometrial cancer_Homo sapiens_hsa052130.61188812
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60493046
98Fatty acid metabolism_Homo sapiens_hsa012120.58506311
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57105437
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.53560487
101Melanoma_Homo sapiens_hsa052180.52779096
102Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52475949
103Complement and coagulation cascades_Homo sapiens_hsa046100.52177663
104Colorectal cancer_Homo sapiens_hsa052100.52019583
105Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48821423
106ABC transporters_Homo sapiens_hsa020100.47826443
107PPAR signaling pathway_Homo sapiens_hsa033200.47541769
108Endocytosis_Homo sapiens_hsa041440.47226152
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.46550766
110FoxO signaling pathway_Homo sapiens_hsa040680.45613768
111PI3K-Akt signaling pathway_Homo sapiens_hsa041510.44077758
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44023012

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