DSG2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This gene is present in a gene cluster with other desmoglein gene family members on chromosome 18. Mutations in this gene have been associated with arrhythmogenic right ventricular dysplasia, familial, 10. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)6.91627991
2hemidesmosome assembly (GO:0031581)6.37417674
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.95170695
4L-phenylalanine catabolic process (GO:0006559)5.95170695
5L-phenylalanine metabolic process (GO:0006558)5.75022414
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.75022414
7intestinal cholesterol absorption (GO:0030299)5.57662310
8aromatic amino acid family catabolic process (GO:0009074)5.52488683
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.50347287
10kynurenine metabolic process (GO:0070189)5.24157166
11tryptophan catabolic process (GO:0006569)5.20373659
12indole-containing compound catabolic process (GO:0042436)5.20373659
13indolalkylamine catabolic process (GO:0046218)5.20373659
14sulfur amino acid catabolic process (GO:0000098)5.12206488
15urea metabolic process (GO:0019627)5.00894031
16urea cycle (GO:0000050)5.00894031
17bile acid and bile salt transport (GO:0015721)4.91076050
18regulation of bile acid biosynthetic process (GO:0070857)4.90664167
19high-density lipoprotein particle remodeling (GO:0034375)4.88400930
20nuclear pore complex assembly (GO:0051292)4.87916000
21tryptophan metabolic process (GO:0006568)4.87533568
22homocysteine metabolic process (GO:0050667)4.82613501
23intestinal absorption (GO:0050892)4.63860283
24cysteine metabolic process (GO:0006534)4.59007214
25nitrogen cycle metabolic process (GO:0071941)4.53866207
26regulation of cholesterol esterification (GO:0010872)4.53747705
27regulation of triglyceride catabolic process (GO:0010896)4.52633926
28glyoxylate metabolic process (GO:0046487)4.51301802
29bile acid biosynthetic process (GO:0006699)4.49453475
30phospholipid efflux (GO:0033700)4.46719884
31reverse cholesterol transport (GO:0043691)4.41187409
32negative regulation of cholesterol transport (GO:0032375)4.36924067
33negative regulation of sterol transport (GO:0032372)4.36924067
34bile acid metabolic process (GO:0008206)4.30456214
35nuclear pore organization (GO:0006999)4.28912898
36alpha-linolenic acid metabolic process (GO:0036109)4.28385835
37protein carboxylation (GO:0018214)4.25713097
38peptidyl-glutamic acid carboxylation (GO:0017187)4.25713097
39amino-acid betaine metabolic process (GO:0006577)4.21791543
40protein-lipid complex remodeling (GO:0034368)4.20704138
41macromolecular complex remodeling (GO:0034367)4.20704138
42plasma lipoprotein particle remodeling (GO:0034369)4.20704138
43gap junction assembly (GO:0016264)4.16088686
44negative regulation of keratinocyte proliferation (GO:0010839)4.15845852
45acylglycerol homeostasis (GO:0055090)4.14064754
46triglyceride homeostasis (GO:0070328)4.14064754
47regulation of protein activation cascade (GO:2000257)4.13100691
48negative regulation of fibrinolysis (GO:0051918)4.12620805
49drug catabolic process (GO:0042737)4.10733507
50cellular glucuronidation (GO:0052695)4.09713209
51lysine catabolic process (GO:0006554)4.09385064
52lysine metabolic process (GO:0006553)4.09385064
53complement activation, alternative pathway (GO:0006957)4.09339684
54flavonoid metabolic process (GO:0009812)4.04057054
55serine family amino acid catabolic process (GO:0009071)4.03593982
56fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.02917128
57regulation of fibrinolysis (GO:0051917)4.02906574
58* bundle of His cell to Purkinje myocyte communication (GO:0086069)4.02388523
59aromatic amino acid family metabolic process (GO:0009072)3.96869383
60plasma lipoprotein particle assembly (GO:0034377)3.91411673
61phospholipid homeostasis (GO:0055091)3.90981615
62imidazole-containing compound metabolic process (GO:0052803)3.90213774
63cholesterol efflux (GO:0033344)3.86239877
64regulation of complement activation (GO:0030449)3.85736232
65cholesterol homeostasis (GO:0042632)3.82785330
66alpha-amino acid catabolic process (GO:1901606)3.81248338
67regulation of cholesterol homeostasis (GO:2000188)3.78137680
68sterol homeostasis (GO:0055092)3.78129701
69very-low-density lipoprotein particle assembly (GO:0034379)3.75973501
70benzene-containing compound metabolic process (GO:0042537)3.71897640
71cellular ketone body metabolic process (GO:0046950)3.66796085
72glucuronate metabolic process (GO:0019585)3.64876343
73uronic acid metabolic process (GO:0006063)3.64876343
74indolalkylamine metabolic process (GO:0006586)3.63933286
75plasma lipoprotein particle clearance (GO:0034381)3.62796803
76cellular amino acid catabolic process (GO:0009063)3.59241583
77establishment of integrated proviral latency (GO:0075713)3.57477602
78paraxial mesoderm development (GO:0048339)3.57330151
79lipoprotein metabolic process (GO:0042157)3.56622980
80tyrosine metabolic process (GO:0006570)3.54567981
81positive regulation of triglyceride lipase activity (GO:0061365)3.53933872
82positive regulation of lipoprotein lipase activity (GO:0051006)3.53933872
83cellular biogenic amine catabolic process (GO:0042402)3.53461093
84amine catabolic process (GO:0009310)3.53461093
85arginine metabolic process (GO:0006525)3.49059102
86protein complex localization (GO:0031503)3.48720992
87COPI coating of Golgi vesicle (GO:0048205)3.48309921
88Golgi transport vesicle coating (GO:0048200)3.48309921
89cellular protein complex localization (GO:0034629)3.46282901
90protein-lipid complex assembly (GO:0065005)3.46228169
91ethanol oxidation (GO:0006069)3.46035055
92response to nitrosative stress (GO:0051409)3.41313766
93intestinal epithelial cell development (GO:0060576)3.39950538
94alkaloid metabolic process (GO:0009820)3.39249317
95regulation of transforming growth factor beta2 production (GO:0032909)3.38161930
96cellular modified amino acid catabolic process (GO:0042219)3.36565532
97heterochromatin organization (GO:0070828)3.35298601
98drug metabolic process (GO:0017144)3.34966842
99pore complex assembly (GO:0046931)3.34535942
100plasma lipoprotein particle organization (GO:0071827)3.33782243
101glutamate metabolic process (GO:0006536)3.32719148
102short-chain fatty acid metabolic process (GO:0046459)3.32295001
103regulation of translational fidelity (GO:0006450)3.32000329
104positive regulation of lipid catabolic process (GO:0050996)3.31999470
105carnitine metabolic process (GO:0009437)3.30519329
106drug transmembrane transport (GO:0006855)3.29432472
107low-density lipoprotein particle remodeling (GO:0034374)3.28611207
108fatty acid oxidation (GO:0019395)3.28498273
109fatty acid beta-oxidation (GO:0006635)3.28358289
110nucleotide-sugar biosynthetic process (GO:0009226)3.28237979
111negative regulation of lipase activity (GO:0060192)3.27962169
112notochord development (GO:0030903)3.27233533
113regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.26386937
114DNA unwinding involved in DNA replication (GO:0006268)3.25815665
115carboxylic acid catabolic process (GO:0046395)3.25007969
116organic acid catabolic process (GO:0016054)3.25007969
117tight junction assembly (GO:0070830)3.24681314
118coenzyme catabolic process (GO:0009109)3.23405266
119glycine metabolic process (GO:0006544)3.22595707
120lipid oxidation (GO:0034440)3.21403773
121negative regulation of fatty acid biosynthetic process (GO:0045717)3.20821372
122keratinocyte proliferation (GO:0043616)3.20062060
1232-oxoglutarate metabolic process (GO:0006103)3.19857612
124proline biosynthetic process (GO:0006561)3.18837391
125protein autoprocessing (GO:0016540)3.10886874
126mitotic sister chromatid cohesion (GO:0007064)3.08428361
127mitotic chromosome condensation (GO:0007076)3.08301354
128ribosome assembly (GO:0042255)3.07578010
129regulation of keratinocyte proliferation (GO:0010837)3.06848582
130epithelial cell-cell adhesion (GO:0090136)3.03757472
131regulation of cardioblast differentiation (GO:0051890)3.02485846
132cell-substrate junction assembly (GO:0007044)2.98159655
133protein localization to kinetochore (GO:0034501)2.89322925
134establishment of apical/basal cell polarity (GO:0035089)2.88827257
135maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.82853605
136cell adhesion mediated by integrin (GO:0033627)2.76592903
137UDP-N-acetylglucosamine metabolic process (GO:0006047)2.74400253
138pre-miRNA processing (GO:0031054)2.74370283
139COPII vesicle coating (GO:0048208)2.72543702
140negative regulation of cell fate specification (GO:0009996)2.71698594
141hippo signaling (GO:0035329)2.70367364
142protein localization to chromosome, centromeric region (GO:0071459)2.70330987
143polarized epithelial cell differentiation (GO:0030859)2.67548668
144regulation of water loss via skin (GO:0033561)2.67344724
145mesodermal cell differentiation (GO:0048333)2.63857726
146cell-cell junction assembly (GO:0007043)2.62597675
147regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.59262746
148folic acid-containing compound biosynthetic process (GO:0009396)2.54436793
149regulation of transforming growth factor beta1 production (GO:0032908)2.54009781
150calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.52730860
151glomerular visceral epithelial cell development (GO:0072015)2.50296708
152regulation of cell fate specification (GO:0042659)2.50156610
153formation of translation preinitiation complex (GO:0001731)2.49237109
154branching involved in mammary gland duct morphogenesis (GO:0060444)2.48571454
155regulation of transforming growth factor beta production (GO:0071634)2.47403318
156DNA strand elongation involved in DNA replication (GO:0006271)2.47212298
157mitotic metaphase plate congression (GO:0007080)2.46544940
158regulation of sister chromatid cohesion (GO:0007063)2.44832558
159regulation of posttranscriptional gene silencing (GO:0060147)2.44400542
160regulation of gene silencing by miRNA (GO:0060964)2.44400542
161regulation of gene silencing by RNA (GO:0060966)2.44400542
162mitotic sister chromatid segregation (GO:0000070)2.43819685
163planar cell polarity pathway involved in neural tube closure (GO:0090179)2.41626882
164protein retention in ER lumen (GO:0006621)2.41260918
165mitotic nuclear envelope disassembly (GO:0007077)2.39543857
166establishment of viral latency (GO:0019043)2.38332784
167L-alpha-amino acid transmembrane transport (GO:1902475)2.38274427
168sister chromatid segregation (GO:0000819)2.37405208
169cytoskeletal anchoring at plasma membrane (GO:0007016)2.36064221
170endothelial cell morphogenesis (GO:0001886)2.34950281
171trophectodermal cell differentiation (GO:0001829)2.34634717
172DNA strand elongation (GO:0022616)2.33242494
173L-serine metabolic process (GO:0006563)2.32931268
174positive regulation of SMAD protein import into nucleus (GO:0060391)2.32393779
175regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.31438702
176anterior/posterior axis specification, embryo (GO:0008595)2.30005710
177chromosome condensation (GO:0030261)2.27207140
178proline metabolic process (GO:0006560)2.26954227
179establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.26251535
180O-glycan processing (GO:0016266)2.25573002
181regulation of RNA export from nucleus (GO:0046831)2.25416062
182activation of Rac GTPase activity (GO:0032863)2.24455298
183transcytosis (GO:0045056)2.23760888
184membrane disassembly (GO:0030397)2.21041856
185nuclear envelope disassembly (GO:0051081)2.21041856
186establishment of skin barrier (GO:0061436)2.20988812
187regulation of stem cell maintenance (GO:2000036)2.20282908
188negative regulation of chondrocyte differentiation (GO:0032331)2.19838216
189regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.19606086
190NADH metabolic process (GO:0006734)2.18987014
191convergent extension (GO:0060026)2.18794665
192DNA replication checkpoint (GO:0000076)2.18144864

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.05165372
2E2F7_22180533_ChIP-Seq_HELA_Human6.60461347
3* RXR_22158963_ChIP-Seq_LIVER_Mouse6.54152635
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.94476149
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.51794355
6LXR_22158963_ChIP-Seq_LIVER_Mouse5.42793919
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.22515403
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.17751039
9TP63_17297297_ChIP-ChIP_HaCaT_Human4.04456119
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.60446255
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.60131055
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.89936536
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.83410309
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.48803356
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.46542626
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.44150947
17SOX2_27498859_Chip-Seq_STOMACH_Mouse2.40208271
18HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.24492504
19KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.23493808
20CDX2_20551321_ChIP-Seq_CACO-2_Human2.22017421
21* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.09213050
22GATA4_25053715_ChIP-Seq_YYC3_Human2.03499756
23E2F4_17652178_ChIP-ChIP_JURKAT_Human2.03367179
24PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.00182003
25MYC_19079543_ChIP-ChIP_MESCs_Mouse1.98200146
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.77819576
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.77646902
28ESR1_21235772_ChIP-Seq_MCF-7_Human1.77061414
29NELFA_20434984_ChIP-Seq_ESCs_Mouse1.74738997
30TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.74681227
31HIF1A_21447827_ChIP-Seq_MCF-7_Human1.73058809
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.71191410
33MYC_19030024_ChIP-ChIP_MESCs_Mouse1.70275062
34* FOXA2_19822575_ChIP-Seq_HepG2_Human1.68690858
35ESR2_21235772_ChIP-Seq_MCF-7_Human1.67767261
36CLOCK_20551151_ChIP-Seq_293T_Human1.63584914
37ZFX_18555785_ChIP-Seq_MESCs_Mouse1.59526816
38GATA6_25053715_ChIP-Seq_YYC3_Human1.57615574
39E2F1_21310950_ChIP-Seq_MCF-7_Human1.57591006
40GATA1_22025678_ChIP-Seq_K562_Human1.55506030
41EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.55085558
42SOX2_20726797_ChIP-Seq_SW620_Human1.53350072
43TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50704625
44KLF4_18555785_ChIP-Seq_MESCs_Mouse1.44771368
45* HNF4A_19822575_ChIP-Seq_HepG2_Human1.44042284
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.43659711
47NANOG_18555785_ChIP-Seq_MESCs_Mouse1.43280223
48ATF3_27146783_Chip-Seq_COLON_Human1.41861831
49PPAR_26484153_Chip-Seq_NCI-H1993_Human1.40206870
50* CHD1_26751641_Chip-Seq_LNCaP_Human1.39990683
51FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.39748661
52ESR1_20079471_ChIP-ChIP_T-47D_Human1.38464518
53FOXO3_23340844_ChIP-Seq_DLD1_Human1.36657432
54MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.34757666
55ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.32728540
56RARG_19884340_ChIP-ChIP_MEFs_Mouse1.32289434
57MYC_18358816_ChIP-ChIP_MESCs_Mouse1.30533018
58* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.29074450
59ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.28922906
60SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.28057413
61ESR1_15608294_ChIP-ChIP_MCF-7_Human1.27373530
62* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26783704
63STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.22917437
64KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.22773245
65KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.22773245
66KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.22773245
67RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.20025161
68SOX17_20123909_ChIP-Seq_XEN_Mouse1.19933160
69TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.19681184
70POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.19617781
71NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.19487996
72SALL4_18804426_ChIP-ChIP_XEN_Mouse1.19461805
73ZNF263_19887448_ChIP-Seq_K562_Human1.18847229
74NANOG_16153702_ChIP-ChIP_HESCs_Human1.18347483
75ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.18285520
76HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.16482024
77* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.16171192
78CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.13137597
79* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12124657
80CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.11038211
81TCF3_18692474_ChIP-Seq_MESCs_Mouse1.08919849
82ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07749815
83KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.07724001
84PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.06843865
85IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.06738264
86CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06650545
87ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05816412
88* NANOG_21062744_ChIP-ChIP_HESCs_Human1.05184914
89HTT_18923047_ChIP-ChIP_STHdh_Human1.05149348
90TRIM28_21343339_ChIP-Seq_HEK293_Human1.04893533
91DCP1A_22483619_ChIP-Seq_HELA_Human1.04203773
92* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.02670158
93AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.01035067
94BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00651498
95FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.99716050
96NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.98264047
97XRN2_22483619_ChIP-Seq_HELA_Human0.98242682
98KAP1_22055183_ChIP-Seq_ESCs_Mouse0.96904135
99MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.95033341
100EGR1_19374776_ChIP-ChIP_THP-1_Human0.94345820
101NANOG_18692474_ChIP-Seq_MEFs_Mouse0.93494293
102SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.92384387
103CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92264015
104GATA3_24758297_ChIP-Seq_MCF-7_Human0.92093657
105CREB1_15753290_ChIP-ChIP_HEK293T_Human0.91958336
106P300_27058665_Chip-Seq_ZR-75-30cells_Human0.90340911
107KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.89258445
108* TTF2_22483619_ChIP-Seq_HELA_Human0.89111042
109* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.87933099
110FOXA1_25552417_ChIP-Seq_VCAP_Human0.87463676
111YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.86955332
112RUNX1_27514584_Chip-Seq_MCF-7_Human0.85604030
113Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.85109636
114PADI4_21655091_ChIP-ChIP_MCF-7_Human0.84989302
115SOX9_24532713_ChIP-Seq_HFSC_Mouse0.84421697
116TCF4_18268006_ChIP-ChIP_LS174T_Human0.83998637
117THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.83771847
118CDX2_22108803_ChIP-Seq_LS180_Human0.83703469
119TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.81774277
120* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.81319569
121NRF2_20460467_ChIP-Seq_MEFs_Mouse0.80772916
122NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.80772916
123FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.80452398
124RACK7_27058665_Chip-Seq_MCF-7_Human0.80359516
125P63_26484246_Chip-Seq_KERATINOCYTES_Human0.79658962
126STAT3_1855785_ChIP-Seq_MESCs_Mouse0.79182659
127BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.77937165
128* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.77801109
129RXRA_24833708_ChIP-Seq_LIVER_Mouse0.76491045
130FOXM1_26456572_ChIP-Seq_MCF-7_Human0.76047641
131PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.75447028
132* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.74076154
133* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.74076154
134POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.73975730
135STAT1_17558387_ChIP-Seq_HELA_Human0.72076950
136PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.71362634
137TCF3_18692474_ChIP-Seq_MEFs_Mouse0.71226773
138BCAT_22108803_ChIP-Seq_LS180_Human0.69742868
139KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.69532550
140PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.68871830
141AUTS2_25519132_ChIP-Seq_293T-REX_Human0.67250083
142GATA2_21666600_ChIP-Seq_HMVEC_Human0.66471154
143EP300_21415370_ChIP-Seq_HL-1_Mouse0.65898608
144RARA_24833708_ChIP-Seq_LIVER_Mouse0.65252254
145PIAS1_25552417_ChIP-Seq_VCAP_Human0.64436250
146CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.64319260
147* TBX20_22328084_ChIP-Seq_HEART_Mouse0.64202812
148* TBX20_22080862_ChIP-Seq_HEART_Mouse0.64202812
149AR_21909140_ChIP-Seq_LNCAP_Human0.64132681
150ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.63801342
151NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.63632158
152TP63_23658742_ChIP-Seq_EP156T_Human0.62859285
153TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.62666731
154NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.62608683
155GATA2_19941826_ChIP-Seq_K562_Human0.62425445
156AHR_22903824_ChIP-Seq_MCF-7_Human0.62234175

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.84195679
2MP0005360_urolithiasis6.59760434
3MP0005085_abnormal_gallbladder_physiolo5.86934763
4MP0005365_abnormal_bile_salt5.27366076
5MP0008875_abnormal_xenobiotic_pharmacok4.43117816
6MP0003252_abnormal_bile_duct3.75817042
7MP0001666_abnormal_nutrient_absorption3.74112242
8MP0002254_reproductive_system_inflammat3.46236322
9MP0003806_abnormal_nucleotide_metabolis3.44343932
10MP0010329_abnormal_lipoprotein_level2.97139934
11MP0003693_abnormal_embryo_hatching2.91932174
12MP0002138_abnormal_hepatobiliary_system2.78827714
13MP0004957_abnormal_blastocyst_morpholog2.71316743
14MP0005083_abnormal_biliary_tract2.65440516
15MP0009840_abnormal_foam_cell2.45495169
16MP0004272_abnormal_basement_membrane2.28877545
17MP0004019_abnormal_vitamin_homeostasis2.25368834
18MP0010234_abnormal_vibrissa_follicle2.21842337
19MP0003195_calcinosis2.19443746
20MP0005332_abnormal_amino_acid2.12672965
21MP0000762_abnormal_tongue_morphology2.06096915
22MP0004264_abnormal_extraembryonic_tissu2.05412649
23MP0003868_abnormal_feces_composition1.97223952
24MP0003890_abnormal_embryonic-extraembry1.82397563
25MP0000609_abnormal_liver_physiology1.76394361
26MP0003111_abnormal_nucleus_morphology1.72515249
27MP0002118_abnormal_lipid_homeostasis1.71976781
28MP0008932_abnormal_embryonic_tissue1.71644488
29MP0001730_embryonic_growth_arrest1.65885965
30MP0003191_abnormal_cellular_cholesterol1.64729645
31MP0002876_abnormal_thyroid_physiology1.62621510
32MP0003315_abnormal_perineum_morphology1.61244913
33MP0003705_abnormal_hypodermis_morpholog1.57753094
34MP0010094_abnormal_chromosome_stability1.55479415
35MP0005319_abnormal_enzyme/_coenzyme1.53627303
36MP0005409_darkened_coat_color1.43258188
37MP0005076_abnormal_cell_differentiation1.40417743
38MP0002697_abnormal_eye_size1.39924128
39MP0009643_abnormal_urine_homeostasis1.39687309
40MP0003937_abnormal_limbs/digits/tail_de1.39521643
41MP0001672_abnormal_embryogenesis/_devel1.33130289
42MP0005380_embryogenesis_phenotype1.33130289
43MP0003077_abnormal_cell_cycle1.31984612
44MP0002877_abnormal_melanocyte_morpholog1.31845479
45MP0003718_maternal_effect1.31218913
46MP0000377_abnormal_hair_follicle1.29779151
47MP0002084_abnormal_developmental_patter1.29481576
48MP0008057_abnormal_DNA_replication1.29403556
49MP0003984_embryonic_growth_retardation1.27635016
50MP0002086_abnormal_extraembryonic_tissu1.27173203
51MP0005451_abnormal_body_composition1.25467679
52MP0005023_abnormal_wound_healing1.24023394
53MP0004185_abnormal_adipocyte_glucose1.22866396
54MP0005257_abnormal_intraocular_pressure1.22057948
55MP0009672_abnormal_birth_weight1.21614371
56MP0002088_abnormal_embryonic_growth/wei1.21328589
57MP0001764_abnormal_homeostasis1.20980257
58MP0000627_abnormal_mammary_gland1.20503888
59* MP0000350_abnormal_cell_proliferation1.17003822
60MP0002796_impaired_skin_barrier1.16983282
61MP0010030_abnormal_orbit_morphology1.15430356
62MP0005084_abnormal_gallbladder_morpholo1.15419051
63MP0002085_abnormal_embryonic_tissue1.14944299
64MP0001697_abnormal_embryo_size1.09936773
65MP0001873_stomach_inflammation1.08173054
66MP0002822_catalepsy1.07428097
67MP0000462_abnormal_digestive_system1.06502287
68MP0010771_integument_phenotype1.05822850
69MP0000490_abnormal_crypts_of1.04962369
70MP0005275_abnormal_skin_tensile1.04841585
71MP0003950_abnormal_plasma_membrane1.03482189
72MP0009697_abnormal_copulation1.03471213
73MP0001346_abnormal_lacrimal_gland1.02498771
74* MP0002080_prenatal_lethality1.00098373
75MP0005647_abnormal_sex_gland0.99882200
76MP0004197_abnormal_fetal_growth/weight/0.99001857
77MP0000579_abnormal_nail_morphology0.97751396
78MP0008007_abnormal_cellular_replicative0.97739943
79MP0002111_abnormal_tail_morphology0.97685306
80MP0000566_synostosis0.96857968
81MP0003119_abnormal_digestive_system0.95206644
82MP0008004_abnormal_stomach_pH0.93924806
83MP0003300_gastrointestinal_ulcer0.93703750
84MP0005584_abnormal_enzyme/coenzyme_acti0.93060459
85MP0003186_abnormal_redox_activity0.89851901
86MP0002098_abnormal_vibrissa_morphology0.89821170
87MP0009053_abnormal_anal_canal0.89745389
88MP0002234_abnormal_pharynx_morphology0.89707667
89MP0008058_abnormal_DNA_repair0.89137091
90MP0000647_abnormal_sebaceous_gland0.88251594
91MP0005220_abnormal_exocrine_pancreas0.88217481
92MP0010307_abnormal_tumor_latency0.87834823
93MP0000538_abnormal_urinary_bladder0.87443860
94MP0002233_abnormal_nose_morphology0.86566744
95MP0004782_abnormal_surfactant_physiolog0.86518071
96MP0000432_abnormal_head_morphology0.86259767
97MP0000598_abnormal_liver_morphology0.85801788
98MP0003453_abnormal_keratinocyte_physiol0.85768047
99MP0005636_abnormal_mineral_homeostasis0.85700741
100MP0001286_abnormal_eye_development0.85573716
101MP0010678_abnormal_skin_adnexa0.84498725
102MP0009384_cardiac_valve_regurgitation0.82037716
103MP0002060_abnormal_skin_morphology0.81925011
104MP0002009_preneoplasia0.81862065
105MP0009764_decreased_sensitivity_to0.81265016
106MP0001293_anophthalmia0.80849909
107MP0003755_abnormal_palate_morphology0.79539689
108MP0005377_hearing/vestibular/ear_phenot0.78230017
109MP0003878_abnormal_ear_physiology0.78230017
110MP0003123_paternal_imprinting0.74816246
111MP0003567_abnormal_fetal_cardiomyocyte0.74177193
112MP0010155_abnormal_intestine_physiology0.73324736
113MP0001881_abnormal_mammary_gland0.72558116
114MP0009703_decreased_birth_body0.72285233
115MP0001663_abnormal_digestive_system0.70876650
116MP0004858_abnormal_nervous_system0.70655007
117MP0005381_digestive/alimentary_phenotyp0.70106404
118MP0000467_abnormal_esophagus_morphology0.68863282
119MP0001661_extended_life_span0.68839758
120MP0002006_tumorigenesis0.68798499
121MP0009642_abnormal_blood_homeostasis0.68583228
122MP0003935_abnormal_craniofacial_develop0.68474244
123MP0005670_abnormal_white_adipose0.67841050
124MP0009763_increased_sensitivity_to0.67634636
125MP0003385_abnormal_body_wall0.67539922
126MP0002837_dystrophic_cardiac_calcinosis0.67239826
127MP0000003_abnormal_adipose_tissue0.67221005
128MP0003943_abnormal_hepatobiliary_system0.66775498
129MP0001849_ear_inflammation0.65986763
130MP0002078_abnormal_glucose_homeostasis0.65110246
131MP0002928_abnormal_bile_duct0.64974855
132MP0000613_abnormal_salivary_gland0.64197152
133MP0005408_hypopigmentation0.62447662
134MP0001216_abnormal_epidermal_layer0.62423929
135MP0010368_abnormal_lymphatic_system0.62324045
136MP0005448_abnormal_energy_balance0.61659603
137MP0008469_abnormal_protein_level0.61611199
138MP0001756_abnormal_urination0.61401480
139MP0005248_abnormal_Harderian_gland0.61214542
140MP0009765_abnormal_xenobiotic_induced0.60713446
141MP0005376_homeostasis/metabolism_phenot0.57928336
142MP0000477_abnormal_intestine_morphology0.57842964
143MP0002136_abnormal_kidney_physiology0.57095281
144MP0001664_abnormal_digestion0.56298571
145MP0005167_abnormal_blood-brain_barrier0.55996791
146MP0005266_abnormal_metabolism0.55843278
147MP0000383_abnormal_hair_follicle0.55609786
148MP0010352_gastrointestinal_tract_polyps0.55013017
149MP0005334_abnormal_fat_pad0.53482535
150MP0000678_abnormal_parathyroid_gland0.52940259
151MP0005501_abnormal_skin_physiology0.52689508
152MP0003283_abnormal_digestive_organ0.52591666
153MP0003941_abnormal_skin_development0.52114785
154MP0003566_abnormal_cell_adhesion0.51941077
155MP0005666_abnormal_adipose_tissue0.50487927
156MP0006036_abnormal_mitochondrial_physio0.50087827
157MP0002971_abnormal_brown_adipose0.49115202
158MP0004043_abnormal_pH_regulation0.48814306
159MP0003011_delayed_dark_adaptation0.48679059
160MP0000470_abnormal_stomach_morphology0.48177696
161MP0003638_abnormal_response/metabolism_0.47796316
162MP0000537_abnormal_urethra_morphology0.46003204
163MP0004130_abnormal_muscle_cell0.45542739

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.98404011
2Abnormality of monocarboxylic acid metabolism (HP:0010996)6.18776137
3Hypobetalipoproteinemia (HP:0003563)5.60134153
4Deep venous thrombosis (HP:0002625)5.56380033
5Abnormality of aromatic amino acid family metabolism (HP:0004338)5.51558981
6Xanthomatosis (HP:0000991)5.20965874
7Prolonged partial thromboplastin time (HP:0003645)5.01866785
8Abnormality of glutamine family amino acid metabolism (HP:0010902)4.72680448
9Hypolipoproteinemia (HP:0010981)4.43614568
10Hypoglycemic coma (HP:0001325)4.39329222
11Fat malabsorption (HP:0002630)4.39007275
12Conjugated hyperbilirubinemia (HP:0002908)4.24199481
13Hyperammonemia (HP:0001987)4.20042203
14* Right ventricular cardiomyopathy (HP:0011663)4.19862991
15Hyperlipoproteinemia (HP:0010980)4.19274258
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.05462509
17Epidermoid cyst (HP:0200040)3.99729061
18Hyperglycinuria (HP:0003108)3.92136401
19Hypoalphalipoproteinemia (HP:0003233)3.90555526
20Complement deficiency (HP:0004431)3.80429704
21Abnormality of sulfur amino acid metabolism (HP:0004339)3.71487500
22Fragile nails (HP:0001808)3.71034575
23Abnormality of aspartate family amino acid metabolism (HP:0010899)3.63212405
24Ketosis (HP:0001946)3.56031058
25Abnormality of serine family amino acid metabolism (HP:0010894)3.46812892
26Abnormality of glycine metabolism (HP:0010895)3.46812892
27Abnormality of the common coagulation pathway (HP:0010990)3.46468786
28Hyperglycinemia (HP:0002154)3.40710828
29Joint hemorrhage (HP:0005261)3.39973723
30Flat acetabular roof (HP:0003180)3.33095488
31Malnutrition (HP:0004395)3.31938400
32Abnormality of the intrinsic pathway (HP:0010989)3.30547874
33Abnormality of methionine metabolism (HP:0010901)3.30300398
34Hypercholesterolemia (HP:0003124)3.20943363
35Abnormality of fatty-acid metabolism (HP:0004359)3.19162926
36Atrophic scars (HP:0001075)3.18166022
37Esophageal varix (HP:0002040)3.16153241
38Pterygium (HP:0001059)3.14364379
39Selective tooth agenesis (HP:0001592)3.07315959
40Abnormality of purine metabolism (HP:0004352)3.07296174
41Abnormality of nucleobase metabolism (HP:0010932)3.06815559
42Abnormality of proline metabolism (HP:0010907)3.06278854
43Hydroxyprolinuria (HP:0003080)3.06278854
44Abnormality of pyrimidine metabolism (HP:0004353)3.05854328
45Steatorrhea (HP:0002570)3.04808874
46Ketoacidosis (HP:0001993)3.04608194
47Ileus (HP:0002595)3.02734441
48Ankyloglossia (HP:0010296)2.98043171
49Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.88366387
50Vascular calcification (HP:0004934)2.85765539
51Abnormal hair laboratory examination (HP:0003328)2.83886336
52Hyperbilirubinemia (HP:0002904)2.79299894
53Hyperactive renin-angiotensin system (HP:0000841)2.78873571
54Hypoglycemic seizures (HP:0002173)2.76982508
55Abnormality of complement system (HP:0005339)2.76790712
56Dicarboxylic aciduria (HP:0003215)2.74652661
57Abnormality of dicarboxylic acid metabolism (HP:0010995)2.74652661
58Deviation of the thumb (HP:0009603)2.67909918
59Gout (HP:0001997)2.65350673
60Hyperglycemia (HP:0003074)2.64166391
61Metabolic acidosis (HP:0001942)2.62682521
62Acanthocytosis (HP:0001927)2.60122986
63Hepatocellular carcinoma (HP:0001402)2.55020366
64Cardiovascular calcification (HP:0011915)2.53325617
65Generalized aminoaciduria (HP:0002909)2.53141402
66Sparse eyelashes (HP:0000653)2.52257522
67Onycholysis (HP:0001806)2.50924074
68Abnormality of nail color (HP:0100643)2.49146239
69Palmoplantar hyperkeratosis (HP:0000972)2.48215844
70Hyperinsulinemic hypoglycemia (HP:0000825)2.47981716
71Lethargy (HP:0001254)2.46560011
72Late onset (HP:0003584)2.44788050
73Palmar hyperkeratosis (HP:0010765)2.43458361
74Symptomatic seizures (HP:0011145)2.41900955
75Abnormality of the salivary glands (HP:0010286)2.41485684
76Abnormality of the distal phalanx of the thumb (HP:0009617)2.41300810
77Hypoplasia of dental enamel (HP:0006297)2.40528088
78Renal cortical cysts (HP:0000803)2.40180073
79Advanced eruption of teeth (HP:0006288)2.33646424
80Absent eyelashes (HP:0000561)2.33638777
81Abnormal gallbladder morphology (HP:0012437)2.31962118
82Proximal placement of thumb (HP:0009623)2.29867377
83Hyperuricemia (HP:0002149)2.29770016
84Increased purine levels (HP:0004368)2.29770016
85Cholelithiasis (HP:0001081)2.28488140
86Myocardial infarction (HP:0001658)2.28371104
87Abnormality of the gastric mucosa (HP:0004295)2.28079025
88Skin nodule (HP:0200036)2.28039589
89Pancreatitis (HP:0001733)2.25362042
90Abnormality of serum amino acid levels (HP:0003112)2.24119383
91Natal tooth (HP:0000695)2.24057091
92Ridged nail (HP:0001807)2.23707729
93Abnormality of oral frenula (HP:0000190)2.22428901
94Woolly hair (HP:0002224)2.21654813
95Hypoplastic labia majora (HP:0000059)2.20400159
96Focal segmental glomerulosclerosis (HP:0000097)2.20263504
97Abdominal distention (HP:0003270)2.16850507
98Glycosuria (HP:0003076)2.16084523
99Abnormality of urine glucose concentration (HP:0011016)2.16084523
100Vertebral clefting (HP:0008428)2.15400978
101Hypochromic microcytic anemia (HP:0004840)2.12968820
102Nail dystrophy (HP:0008404)2.12007029
103Abnormal biliary tract morphology (HP:0012440)2.11980348
104Cerebral edema (HP:0002181)2.11612483
105Spontaneous abortion (HP:0005268)2.11561373
106Fragile skin (HP:0001030)2.10409631
107Abnormality of vitamin metabolism (HP:0100508)2.09353242
108Abnormality of the lacrimal duct (HP:0011481)2.09018619
109Proximal tubulopathy (HP:0000114)2.08031861
110Enlarged kidneys (HP:0000105)2.06105394
111Delayed CNS myelination (HP:0002188)2.04833053
112Plantar hyperkeratosis (HP:0007556)2.03910931
113Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.02800313
114Vertebral hypoplasia (HP:0008417)2.02800313
115Rickets (HP:0002748)2.01352559
116Septate vagina (HP:0001153)2.00483566
117Abnormal cartilage morphology (HP:0002763)2.00357446
118Glomerulosclerosis (HP:0000096)1.99646219
119Milia (HP:0001056)1.98809752
120Hemorrhage of the eye (HP:0011885)1.97789993
121Chromsome breakage (HP:0040012)1.97491252
122Poikilocytosis (HP:0004447)1.94773222
123Lip pit (HP:0100267)1.94471525
124Abnormal tarsal ossification (HP:0008369)1.94316613
125Biliary tract neoplasm (HP:0100574)1.94286840
126Syncope (HP:0001279)1.93722892
127Thick nail (HP:0001805)1.89829989
128Trismus (HP:0000211)1.89823722
129Abnormality of the labia majora (HP:0012881)1.88549991
130Abnormality of the nasal septum (HP:0000419)1.88408442
131Popliteal pterygium (HP:0009756)1.88375064
132Abnormality of transition element cation homeostasis (HP:0011030)1.88173893
133Abnormal foot bone ossification (HP:0010675)1.87250892
134Curly hair (HP:0002212)1.87079390
135Abnormal enzyme/coenzyme activity (HP:0012379)1.86982613
136Absent eyebrow (HP:0002223)1.86397071
137Nausea (HP:0002018)1.86359489
138Systemic lupus erythematosus (HP:0002725)1.86091474
139Esophageal atresia (HP:0002032)1.84910682
140Abnormality of carpal bone ossification (HP:0006257)1.84491445
141Alopecia of scalp (HP:0002293)1.83422222
142Missing ribs (HP:0000921)1.83366874
143Pigmentary retinal degeneration (HP:0001146)1.82683687
144Chromosomal breakage induced by crosslinking agents (HP:0003221)1.82085435
145Osteolytic defects of the phalanges of the hand (HP:0009771)1.81470922
146Osteolytic defects of the hand bones (HP:0009699)1.81470922
147Abnormality of permanent molar morphology (HP:0011071)1.80625759
148Abnormality of the dental root (HP:0006486)1.80625759
149Taurodontia (HP:0000679)1.80625759
150Vomiting (HP:0002013)1.80208225
151Spastic diplegia (HP:0001264)1.78213238
152Abnormality of the gallbladder (HP:0005264)1.77933903
153Aplasia cutis congenita (HP:0001057)1.76841033
154Irritability (HP:0000737)1.76229676
155Pili torti (HP:0003777)1.76086572
156Abnormality of the nasolacrimal system (HP:0000614)1.73746436
157Cholecystitis (HP:0001082)1.72177148
158Abnormal gallbladder physiology (HP:0012438)1.72177148
159Abnormality of the distal phalanges of the toes (HP:0010182)1.70937357
160Uterine neoplasm (HP:0010784)1.69228346
161Ureteral duplication (HP:0000073)1.67913054
162Increased nuchal translucency (HP:0010880)1.66415542
163Blepharitis (HP:0000498)1.65895116
164Hypotrichosis (HP:0001006)1.65453742
165Nasolacrimal duct obstruction (HP:0000579)1.65291126
166Gastrointestinal carcinoma (HP:0002672)1.62982527
167Malignant gastrointestinal tract tumors (HP:0006749)1.62982527
168Abnormality of chloride homeostasis (HP:0011422)1.62868912
169Nephroblastoma (Wilms tumor) (HP:0002667)1.61559279
170Abnormal blistering of the skin (HP:0008066)1.60267942
171Tracheal stenosis (HP:0002777)1.59717166
172Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.57424318
173Abnormality of molar morphology (HP:0011070)1.57230094
174Abnormality of molar (HP:0011077)1.57230094
175Short humerus (HP:0005792)1.57037731
17611 pairs of ribs (HP:0000878)1.56626619
177Anal stenosis (HP:0002025)1.56239831
178Facial cleft (HP:0002006)1.55484704
179Megaloblastic anemia (HP:0001889)1.55319469
180Neonatal death (HP:0003811)1.54943397
181Abnormal vertebral ossification (HP:0100569)1.54913536

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R5.89899174
2FRK4.16966692
3EPHA24.04080563
4BCKDK3.50692053
5PIK3CA2.90561284
6FGFR42.82161292
7LMTK22.64378628
8PBK2.51936998
9INSRR2.50834252
10MET2.50340885
11TTK2.39553263
12LATS12.38923809
13SIK12.32238699
14MAP2K22.28776168
15PTK62.25616189
16TAOK32.23621521
17MST42.10868793
18ERN12.07247321
19MAP3K22.03588616
20ERBB41.96886039
21NEK11.94562504
22CDK121.90569621
23BUB11.89769022
24TSSK61.89576920
25LATS21.88022056
26STK391.79070438
27RIPK11.67218977
28PAK41.61183725
29SMG11.56353105
30PKN21.54701036
31SRPK11.52441296
32STK38L1.51121662
33EEF2K1.51002614
34CDC71.44585265
35EPHA31.42588051
36EIF2AK31.41459891
37BRSK21.38480323
38MAP3K31.37016784
39PRKG21.36361032
40EIF2AK11.36273302
41EPHB11.34006757
42MYLK1.30432646
43AKT31.28933808
44PDGFRA1.28356581
45TAF11.27612470
46PLK41.22566347
47MAP3K91.21622626
48MAPK151.21555313
49IRAK31.21073300
50SCYL21.19480975
51MAP3K141.19371898
52FER1.17557387
53PTK21.16309509
54EPHB21.16074345
55NME11.12984429
56NUAK11.12257180
57WEE11.11383800
58MAP2K11.09318690
59TRIM281.09154754
60ERBB21.07221678
61NME21.07038123
62PIK3CG1.05054537
63NEK21.04950579
64MAP3K121.03570997
65PRKAA21.03514510
66BCR0.97301331
67VRK20.96877400
68MAPK110.95759362
69PLK30.95490325
70MKNK10.94455186
71ACVR1B0.92735155
72TYK20.92554035
73ICK0.91419186
74RPS6KB20.88473214
75MAP3K70.81938728
76AURKB0.77818819
77MAP3K10.77133307
78PLK10.76777158
79GRK10.76681051
80JAK20.75773082
81FLT30.75418847
82NLK0.74528427
83PDK20.74278057
84NTRK10.73240471
85CDK70.73191112
86TNIK0.72181224
87MAP2K60.70077380
88DYRK1B0.69196273
89PDK40.67919938
90PDK30.67919938
91CHEK20.67057143
92OXSR10.65432073
93NEK90.64703093
94EIF2AK20.64259843
95CAMK1D0.61402110
96TRIB30.61395692
97CHEK10.60335236
98PRKCI0.59673026
99CAMK1G0.59443114
100GRK60.57552470
101TBK10.57272869
102BRD40.56907174
103PNCK0.56535268
104ERBB30.56454437
105MAP3K100.56202114
106CHUK0.55820850
107FGFR30.55487247
108KSR20.51414177
109CAMK2D0.51270418
110GSK3A0.51243280
111DMPK0.50133523
112PRKAA10.49562588
113CAMK2G0.48747784
114FGFR20.48713374
115BRSK10.48577861
116PASK0.48368068
117YES10.47881523
118MKNK20.46129073
119CSNK1E0.45204896
120STK30.44445832
121ATM0.44049696
122JAK10.43699582
123WNK40.43612551
124IRAK10.42763720
125MELK0.42651054
126PAK30.42462298
127DAPK20.42329505
128AKT20.42300452
129BMX0.41935650
130ZAK0.41780919
131TIE10.41372573
132ALK0.39627250
133CSK0.39169979
134ATR0.37852845
135MATK0.36912714
136CDK60.36089242
137RPS6KA40.35891604
138PRKACG0.35159209
139STK100.35039802
140TTN0.34991042
141TRPM70.34772669
142MAP3K80.34474709
143OBSCN0.34076733
144CDC42BPA0.33482554
145PDGFRB0.32442530
146CDK10.32415227
147BRAF0.31628129
148WNK10.30531310
149IGF1R0.30431285
150MTOR0.29774987
151MAPKAPK30.28683780
152MAP3K110.26158514
153RPS6KA10.26126992
154PRKCZ0.25738179
155IKBKE0.25504619
156RET0.23723753
157KDR0.23674409
158CDK90.23504631
159PRKCA0.21814289
160PRKCE0.21367713
161STK240.21177635
162FGFR10.19604163

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.48600598
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.23264208
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.18953033
4Nitrogen metabolism_Homo sapiens_hsa009102.95711861
5Arginine biosynthesis_Homo sapiens_hsa002202.78424971
6Tryptophan metabolism_Homo sapiens_hsa003802.70008768
7Fatty acid degradation_Homo sapiens_hsa000712.52512982
8Sulfur metabolism_Homo sapiens_hsa009202.42363450
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.33226507
10Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.31128398
11Histidine metabolism_Homo sapiens_hsa003402.30897116
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.27490851
13Fat digestion and absorption_Homo sapiens_hsa049752.26545419
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.20970245
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.14023562
16Complement and coagulation cascades_Homo sapiens_hsa046102.08471559
17Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.04953053
18DNA replication_Homo sapiens_hsa030301.99151872
19Chemical carcinogenesis_Homo sapiens_hsa052041.98837456
20Caffeine metabolism_Homo sapiens_hsa002321.97390881
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.95009274
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.93145847
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.91785913
24Propanoate metabolism_Homo sapiens_hsa006401.90227142
25Butanoate metabolism_Homo sapiens_hsa006501.86496893
26PPAR signaling pathway_Homo sapiens_hsa033201.82701892
27Mismatch repair_Homo sapiens_hsa034301.81023809
28Non-homologous end-joining_Homo sapiens_hsa034501.75359328
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.74655359
30Peroxisome_Homo sapiens_hsa041461.74500366
31beta-Alanine metabolism_Homo sapiens_hsa004101.73511575
32Phenylalanine metabolism_Homo sapiens_hsa003601.69535472
33Bile secretion_Homo sapiens_hsa049761.68937476
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.65788000
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.64331252
36Fatty acid metabolism_Homo sapiens_hsa012121.63089755
37Starch and sucrose metabolism_Homo sapiens_hsa005001.63042583
38Vitamin digestion and absorption_Homo sapiens_hsa049771.57670911
39Retinol metabolism_Homo sapiens_hsa008301.57489098
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.51393622
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45499276
42Cell cycle_Homo sapiens_hsa041101.44096142
43Drug metabolism - other enzymes_Homo sapiens_hsa009831.43127633
44Selenocompound metabolism_Homo sapiens_hsa004501.41956691
45RNA transport_Homo sapiens_hsa030131.40948982
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.38240594
47Folate biosynthesis_Homo sapiens_hsa007901.36862897
48ECM-receptor interaction_Homo sapiens_hsa045121.35197300
49Tyrosine metabolism_Homo sapiens_hsa003501.31439347
50Pyruvate metabolism_Homo sapiens_hsa006201.28703867
51ABC transporters_Homo sapiens_hsa020101.27842948
52Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.24465673
53Cyanoamino acid metabolism_Homo sapiens_hsa004601.19998767
54Hippo signaling pathway_Homo sapiens_hsa043901.17340778
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.13636121
56Carbon metabolism_Homo sapiens_hsa012001.13370874
57Staphylococcus aureus infection_Homo sapiens_hsa051501.13121329
58Arginine and proline metabolism_Homo sapiens_hsa003301.08878940
59Cysteine and methionine metabolism_Homo sapiens_hsa002701.08821161
60N-Glycan biosynthesis_Homo sapiens_hsa005101.08575820
61Small cell lung cancer_Homo sapiens_hsa052221.07075862
62Nucleotide excision repair_Homo sapiens_hsa034201.06920502
63Central carbon metabolism in cancer_Homo sapiens_hsa052301.00530975
64Glutathione metabolism_Homo sapiens_hsa004800.99979729
65Biosynthesis of amino acids_Homo sapiens_hsa012300.99906360
66Spliceosome_Homo sapiens_hsa030400.98479515
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.97722315
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.97653197
69mRNA surveillance pathway_Homo sapiens_hsa030150.95299276
70Glycerolipid metabolism_Homo sapiens_hsa005610.95106079
71Steroid biosynthesis_Homo sapiens_hsa001000.95070908
72Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94790712
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94085192
74Fatty acid elongation_Homo sapiens_hsa000620.93903362
75Base excision repair_Homo sapiens_hsa034100.86173567
76Sulfur relay system_Homo sapiens_hsa041220.83405756
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80974762
78TGF-beta signaling pathway_Homo sapiens_hsa043500.80739904
79Galactose metabolism_Homo sapiens_hsa000520.79628754
80Sphingolipid metabolism_Homo sapiens_hsa006000.79379693
81Mineral absorption_Homo sapiens_hsa049780.78024558
82Basal cell carcinoma_Homo sapiens_hsa052170.77921440
83Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77528587
84Lysine degradation_Homo sapiens_hsa003100.77076045
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.77029921
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75674179
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75110988
88MicroRNAs in cancer_Homo sapiens_hsa052060.73978100
89p53 signaling pathway_Homo sapiens_hsa041150.72638350
90Linoleic acid metabolism_Homo sapiens_hsa005910.71402578
91Proteoglycans in cancer_Homo sapiens_hsa052050.68718812
92Fructose and mannose metabolism_Homo sapiens_hsa000510.64964713
93Proteasome_Homo sapiens_hsa030500.63107936
94Pyrimidine metabolism_Homo sapiens_hsa002400.58324756
95Focal adhesion_Homo sapiens_hsa045100.58318815
96Wnt signaling pathway_Homo sapiens_hsa043100.55725209
97Homologous recombination_Homo sapiens_hsa034400.52960735
98Renin-angiotensin system_Homo sapiens_hsa046140.52054939
99Fatty acid biosynthesis_Homo sapiens_hsa000610.49667055
100Pentose phosphate pathway_Homo sapiens_hsa000300.48326213
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47169011
102Metabolic pathways_Homo sapiens_hsa011000.46630776
103Protein digestion and absorption_Homo sapiens_hsa049740.44497601
104Prostate cancer_Homo sapiens_hsa052150.44460850
105One carbon pool by folate_Homo sapiens_hsa006700.41670196
106Basal transcription factors_Homo sapiens_hsa030220.41575950
107Vitamin B6 metabolism_Homo sapiens_hsa007500.34210636
108Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30627954
109Insulin resistance_Homo sapiens_hsa049310.29909145
110Arachidonic acid metabolism_Homo sapiens_hsa005900.28569596
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.25538950
112Pancreatic secretion_Homo sapiens_hsa049720.19656575
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.13109961
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.11783725
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.10969471
116Bladder cancer_Homo sapiens_hsa052190.09280767
117Tight junction_Homo sapiens_hsa045300.08592684
118Adherens junction_Homo sapiens_hsa045200.08438528
119Prion diseases_Homo sapiens_hsa050200.07869063
120Hepatitis C_Homo sapiens_hsa051600.06292996
121African trypanosomiasis_Homo sapiens_hsa051430.03168663
122Thyroid hormone synthesis_Homo sapiens_hsa049180.03163323
123Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.00952727
124Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0814529
125Ether lipid metabolism_Homo sapiens_hsa00565-0.0704113
126* Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412-0.0549630
127Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550-0.0527282
128AMPK signaling pathway_Homo sapiens_hsa04152-0.0387446
129Thyroid cancer_Homo sapiens_hsa05216-0.0239784
130Glucagon signaling pathway_Homo sapiens_hsa04922-0.0099534
131Amoebiasis_Homo sapiens_hsa05146-0.0084173

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