DSC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of skin barrier (GO:0061436)9.47209568
2regulation of water loss via skin (GO:0033561)8.87491724
3negative regulation of keratinocyte proliferation (GO:0010839)7.73239814
4keratinocyte proliferation (GO:0043616)7.20527223
5keratinocyte differentiation (GO:0030216)6.99772372
6gap junction assembly (GO:0016264)6.38134441
7regulation of keratinocyte proliferation (GO:0010837)6.06680306
8multicellular organismal water homeostasis (GO:0050891)6.03001944
9intermediate filament organization (GO:0045109)5.97142535
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.94260685
11L-phenylalanine catabolic process (GO:0006559)5.94260685
12L-phenylalanine metabolic process (GO:0006558)5.78052929
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.78052929
14epidermal cell differentiation (GO:0009913)5.72887969
15triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.67483346
16molting cycle (GO:0042303)5.65393265
17hair cycle (GO:0042633)5.65393265
18aromatic amino acid family catabolic process (GO:0009074)5.29667198
19epidermis development (GO:0008544)5.29594140
20sulfur amino acid catabolic process (GO:0000098)5.16106928
21peptide cross-linking (GO:0018149)5.03121396
22water homeostasis (GO:0030104)5.02967250
23high-density lipoprotein particle remodeling (GO:0034375)4.98447192
24kynurenine metabolic process (GO:0070189)4.96882001
25urea cycle (GO:0000050)4.95406263
26urea metabolic process (GO:0019627)4.95406263
27intestinal epithelial cell development (GO:0060576)4.95405874
28indole-containing compound catabolic process (GO:0042436)4.79594501
29indolalkylamine catabolic process (GO:0046218)4.79594501
30tryptophan catabolic process (GO:0006569)4.79594501
31glyoxylate metabolic process (GO:0046487)4.69263813
32intestinal cholesterol absorption (GO:0030299)4.65012039
33alpha-linolenic acid metabolic process (GO:0036109)4.64569817
34cysteine metabolic process (GO:0006534)4.64365012
35bile acid biosynthetic process (GO:0006699)4.61832668
36bile acid and bile salt transport (GO:0015721)4.57601494
37regulation of triglyceride catabolic process (GO:0010896)4.57283444
38keratinocyte development (GO:0003334)4.55651410
39tryptophan metabolic process (GO:0006568)4.54894393
40protein carboxylation (GO:0018214)4.53828175
41peptidyl-glutamic acid carboxylation (GO:0017187)4.53828175
42regulation of cholesterol esterification (GO:0010872)4.51284713
43reverse cholesterol transport (GO:0043691)4.50621939
44nitrogen cycle metabolic process (GO:0071941)4.49559720
45negative regulation of fibrinolysis (GO:0051918)4.45480081
46cellular glucuronidation (GO:0052695)4.42358020
47regulation of transforming growth factor beta2 production (GO:0032909)4.40570992
48phospholipid efflux (GO:0033700)4.40391714
49regulation of protein activation cascade (GO:2000257)4.40052279
50bile acid metabolic process (GO:0008206)4.38383429
51homocysteine metabolic process (GO:0050667)4.38169903
52protein-lipid complex remodeling (GO:0034368)4.33576212
53macromolecular complex remodeling (GO:0034367)4.33576212
54plasma lipoprotein particle remodeling (GO:0034369)4.33576212
55lysine catabolic process (GO:0006554)4.31969317
56lysine metabolic process (GO:0006553)4.31969317
57negative regulation of sterol transport (GO:0032372)4.28629689
58negative regulation of cholesterol transport (GO:0032375)4.28629689
59intestinal absorption (GO:0050892)4.27574877
60ectoderm development (GO:0007398)4.26536768
61intermediate filament cytoskeleton organization (GO:0045104)4.25052843
62complement activation, alternative pathway (GO:0006957)4.24756501
63regulation of fibrinolysis (GO:0051917)4.23558910
64amino-acid betaine metabolic process (GO:0006577)4.22417888
65fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.19761674
66cell-substrate junction assembly (GO:0007044)4.15702096
67flavonoid metabolic process (GO:0009812)4.15293792
68surfactant homeostasis (GO:0043129)4.14911282
69regulation of complement activation (GO:0030449)4.12573388
70drug catabolic process (GO:0042737)4.11714987
71acylglycerol homeostasis (GO:0055090)4.09765238
72triglyceride homeostasis (GO:0070328)4.09765238
73regulation of bile acid biosynthetic process (GO:0070857)4.09207502
74intermediate filament-based process (GO:0045103)4.08302325
75serine family amino acid catabolic process (GO:0009071)3.99642491
76phospholipid homeostasis (GO:0055091)3.99360668
77uronic acid metabolic process (GO:0006063)3.96299760
78glucuronate metabolic process (GO:0019585)3.96299760
79regulation of cardioblast differentiation (GO:0051890)3.94970018
80cellular ketone body metabolic process (GO:0046950)3.94472196
81cholesterol efflux (GO:0033344)3.93167144
82plasma lipoprotein particle assembly (GO:0034377)3.93102906
83positive regulation of epidermal cell differentiation (GO:0045606)3.91704876
84* bundle of His cell to Purkinje myocyte communication (GO:0086069)3.88121525
85ethanol oxidation (GO:0006069)3.87999722
86aromatic amino acid family metabolic process (GO:0009072)3.87330537
87regulation of cholesterol homeostasis (GO:2000188)3.83898512
88plasma lipoprotein particle clearance (GO:0034381)3.83549553
89polarized epithelial cell differentiation (GO:0030859)3.80137717
90cholesterol homeostasis (GO:0042632)3.77006612
91lipoprotein metabolic process (GO:0042157)3.75799682
92chemical homeostasis within a tissue (GO:0048875)3.73791754
93tyrosine metabolic process (GO:0006570)3.72756490
94alpha-amino acid catabolic process (GO:1901606)3.72566345
95sterol homeostasis (GO:0055092)3.72264882
96establishment of tissue polarity (GO:0007164)3.69380239
97establishment of planar polarity (GO:0001736)3.69380239
98very-low-density lipoprotein particle assembly (GO:0034379)3.67215644
99benzene-containing compound metabolic process (GO:0042537)3.64047226
100skin morphogenesis (GO:0043589)3.63162214
101protein-lipid complex assembly (GO:0065005)3.59908344
102positive regulation of lipoprotein lipase activity (GO:0051006)3.59779940
103positive regulation of triglyceride lipase activity (GO:0061365)3.59779940
104* ventricular cardiac muscle cell action potential (GO:0086005)3.58359166
105positive regulation of epidermis development (GO:0045684)3.57918111
106cellular amino acid catabolic process (GO:0009063)3.52563009
107response to nitrosative stress (GO:0051409)3.51792740
108negative regulation of lipase activity (GO:0060192)3.47531140
109positive regulation of lipid catabolic process (GO:0050996)3.45595792
110cellular modified amino acid catabolic process (GO:0042219)3.43267293
111glutamate metabolic process (GO:0006536)3.43138916
112sphingosine metabolic process (GO:0006670)3.42208200
113ketone body metabolic process (GO:1902224)3.41292761
114regulation of hair follicle development (GO:0051797)3.41172548
115regulation of keratinocyte differentiation (GO:0045616)3.39518050
116plasma lipoprotein particle organization (GO:0071827)3.38632330
117low-density lipoprotein particle remodeling (GO:0034374)3.37686405
118ethanol metabolic process (GO:0006067)3.36733250
119short-chain fatty acid metabolic process (GO:0046459)3.36657419
120carnitine metabolic process (GO:0009437)3.36110945
121arginine metabolic process (GO:0006525)3.35232976
122fatty acid oxidation (GO:0019395)3.35023619
123indolalkylamine metabolic process (GO:0006586)3.34947926
124fatty acid beta-oxidation (GO:0006635)3.34581136
125drug metabolic process (GO:0017144)3.33931002
126xenobiotic catabolic process (GO:0042178)3.32719096
127epithelial cell differentiation involved in prostate gland development (GO:0060742)3.31773678
128fibrinolysis (GO:0042730)3.30926941
129imidazole-containing compound metabolic process (GO:0052803)3.30699012
130lipid oxidation (GO:0034440)3.27293021
131glycine metabolic process (GO:0006544)3.25823098
132lateral sprouting from an epithelium (GO:0060601)3.24553808
133exogenous drug catabolic process (GO:0042738)3.22916003
134protein-lipid complex subunit organization (GO:0071825)3.22872299
1352-oxoglutarate metabolic process (GO:0006103)3.22798233
136serine family amino acid metabolic process (GO:0009069)3.22248215
137organic acid catabolic process (GO:0016054)3.21837556
138sphingoid metabolic process (GO:0046519)3.21141636
139negative regulation of epidermis development (GO:0045683)3.18128033
140regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.16463423
141regulation of transforming growth factor beta production (GO:0071634)3.16363533
142diol metabolic process (GO:0034311)3.13142132
143auditory receptor cell differentiation (GO:0042491)3.12583125
144calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.11741248
145regulation of transforming growth factor beta1 production (GO:0032908)3.11733536
146tight junction assembly (GO:0070830)3.10899116
147regulation of epidermis development (GO:0045682)3.07407499
148epithelial cell-cell adhesion (GO:0090136)3.07297529
149cell-cell junction assembly (GO:0007043)3.01137233
150genitalia morphogenesis (GO:0035112)2.98665905
151negative regulation of cell fate specification (GO:0009996)2.96883620
152regulation of hair cycle (GO:0042634)2.95909418
153hair cell differentiation (GO:0035315)2.92833497
154* regulation of heart rate by cardiac conduction (GO:0086091)2.91859483
155cytoskeletal anchoring at plasma membrane (GO:0007016)2.86355789
156cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.84010295
157sulfate transmembrane transport (GO:1902358)2.80073393
158detection of bacterium (GO:0016045)2.79701002
159epithelium development (GO:0060429)2.78349882
160phosphatidylserine acyl-chain remodeling (GO:0036150)2.76609735
161* cell communication involved in cardiac conduction (GO:0086065)2.74778877
162detection of other organism (GO:0098543)2.73385771
163angiotensin maturation (GO:0002003)2.73282285
164regulation of epidermal cell differentiation (GO:0045604)2.72834282
165notochord development (GO:0030903)2.69007755
166positive regulation of keratinocyte differentiation (GO:0045618)2.68800936
167protein autoprocessing (GO:0016540)2.67959029
168O-glycan processing (GO:0016266)2.66334119
169positive regulation of glycoprotein biosynthetic process (GO:0010560)2.65204744
170renal filtration (GO:0097205)2.62898167
171cell junction assembly (GO:0034329)2.62572141
172vitamin A metabolic process (GO:0006776)2.62481506
173trophectodermal cell differentiation (GO:0001829)2.62102936
174mesodermal cell differentiation (GO:0048333)2.60556314
175sequestering of metal ion (GO:0051238)2.59006029
176cell junction organization (GO:0034330)2.57704497
177transcytosis (GO:0045056)2.54897942
178atrioventricular valve morphogenesis (GO:0003181)2.54242512
179sphingomyelin metabolic process (GO:0006684)2.52301724
180linoleic acid metabolic process (GO:0043651)2.50055459
181cell adhesion mediated by integrin (GO:0033627)2.49912990
182hair follicle morphogenesis (GO:0031069)2.47143671
183maintenance of gastrointestinal epithelium (GO:0030277)2.45960274
184positive regulation of glycoprotein metabolic process (GO:1903020)2.43796600
185cardiac right ventricle morphogenesis (GO:0003215)2.43454210
186phosphatidylinositol acyl-chain remodeling (GO:0036149)2.43363786
187skin development (GO:0043588)2.39481265
188lipoxygenase pathway (GO:0019372)2.38492441
189renal system process involved in regulation of blood volume (GO:0001977)2.37921171
190desmosome organization (GO:0002934)13.0415631
191hemidesmosome assembly (GO:0031581)12.2003765
192keratinization (GO:0031424)10.1466539

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.24697302
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.69868305
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.01686546
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.48366734
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.16653389
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.64019700
7TP63_17297297_ChIP-ChIP_HaCaT_Human4.41191317
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.07766431
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.62822304
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.57882028
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.53864802
12* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.39923017
13SOX2_27498859_Chip-Seq_STOMACH_Mouse2.31325078
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.28836250
15CLOCK_20551151_ChIP-Seq_293T_Human2.14020373
16CDX2_20551321_ChIP-Seq_CACO-2_Human2.01974416
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.90320841
18GATA4_25053715_ChIP-Seq_YYC3_Human1.89697506
19STAT6_21828071_ChIP-Seq_BEAS2B_Human1.85164155
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.76241664
21ESR2_21235772_ChIP-Seq_MCF-7_Human1.75282222
22TRIM28_21343339_ChIP-Seq_HEK293_Human1.73655976
23FOXA2_19822575_ChIP-Seq_HepG2_Human1.70673817
24ESR1_21235772_ChIP-Seq_MCF-7_Human1.69326536
25* AR_21909140_ChIP-Seq_LNCAP_Human1.68959945
26ESR1_20079471_ChIP-ChIP_T-47D_Human1.68487004
27TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.68309008
28RARG_19884340_ChIP-ChIP_MEFs_Mouse1.65293068
29GATA1_22025678_ChIP-Seq_K562_Human1.59621206
30ZNF263_19887448_ChIP-Seq_K562_Human1.54625105
31GATA6_25053715_ChIP-Seq_YYC3_Human1.50577539
32* SOX2_20726797_ChIP-Seq_SW620_Human1.48635879
33PPAR_26484153_Chip-Seq_NCI-H1993_Human1.41510989
34HNF4A_19822575_ChIP-Seq_HepG2_Human1.38633625
35AHR_22903824_ChIP-Seq_MCF-7_Human1.36923879
36FOXO3_23340844_ChIP-Seq_DLD1_Human1.33514790
37NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.31909396
38ESR1_15608294_ChIP-ChIP_MCF-7_Human1.31591325
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.31181346
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.30446716
41SMAD3_21741376_ChIP-Seq_HESCs_Human1.27710885
42KLF5_25053715_ChIP-Seq_YYC3_Human1.23193051
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.19740618
44SALL4_18804426_ChIP-ChIP_XEN_Mouse1.18634576
45CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.17188095
46* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.16623691
47ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.14972628
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13868140
49RXR_22108803_ChIP-Seq_LS180_Human1.13859748
50RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.10410598
51PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.10223575
52AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.09584638
53FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09304597
54BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08530036
55SALL1_21062744_ChIP-ChIP_HESCs_Human1.08199552
56ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08197273
57KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07482826
58* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.06595533
59ARNT_22903824_ChIP-Seq_MCF-7_Human1.04958181
60EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.04778949
61HTT_18923047_ChIP-ChIP_STHdh_Human1.03911156
62NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.03030533
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02006418
64THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.01404125
65TP53_18474530_ChIP-ChIP_U2OS_Human1.00872777
66ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98710624
67FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.97653676
68NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.95955210
69GATA3_24758297_ChIP-Seq_MCF-7_Human0.95633233
70RACK7_27058665_Chip-Seq_MCF-7_Human0.94442079
71ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.93987218
72RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93623976
73TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91991771
74UBF1/2_26484160_Chip-Seq_HMECs_Human0.91479764
75HIF1A_21447827_ChIP-Seq_MCF-7_Human0.91176704
76NRF2_20460467_ChIP-Seq_MEFs_Mouse0.90440710
77NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.90440710
78SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90147774
79ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.88042079
80CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.87213107
81PCGF2_27294783_Chip-Seq_NPCs_Mouse0.87193366
82RUNX1_27514584_Chip-Seq_MCF-7_Human0.86903543
83P63_26484246_Chip-Seq_KERATINOCYTES_Human0.86504613
84SOX9_24532713_ChIP-Seq_HFSC_Mouse0.86486448
85EP300_21415370_ChIP-Seq_HL-1_Mouse0.86416965
86ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.84906054
87FOXA1_25552417_ChIP-Seq_VCAP_Human0.84402554
88PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.84055603
89CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.83678782
90* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.83199616
91* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.83199616
92CTNNB1_20460455_ChIP-Seq_HCT116_Human0.82075001
93* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.81749452
94ATF3_27146783_Chip-Seq_COLON_Human0.81316452
95TCF3_18692474_ChIP-Seq_MEFs_Mouse0.80966199
96TCF3_18692474_ChIP-Seq_MESCs_Mouse0.80458280
97NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.80254485
98TBX20_22080862_ChIP-Seq_HEART_Mouse0.79404856
99TBX20_22328084_ChIP-Seq_HEART_Mouse0.79404856
100STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.78538317
101TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77911136
102Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.77603314
103EGR1_19032775_ChIP-ChIP_M12_Human0.77505604
104IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.76850231
105* TP63_22573176_ChIP-Seq_HFKS_Human0.76794107
106PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.75933622
107FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.75361397
108PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.75313915
109RXRA_24833708_ChIP-Seq_LIVER_Mouse0.75292165
110TCF4_22108803_ChIP-Seq_LS180_Human0.74536826
111CHD1_26751641_Chip-Seq_LNCaP_Human0.73953914
112TP53_16413492_ChIP-PET_HCT116_Human0.73451347
113BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.73251815
114TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.72695486
115GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.71151546
116ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.71063932
117GATA2_19941826_ChIP-Seq_K562_Human0.70867284
118NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.70332735
119SMAD3_21741376_ChIP-Seq_EPCs_Human0.69665861
120PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.69243040
121FOXM1_26456572_ChIP-Seq_MCF-7_Human0.69073766
122BCAT_22108803_ChIP-Seq_LS180_Human0.68980381
123TP63_23658742_ChIP-Seq_EP156T_Human0.67567686
124CDX2_22108803_ChIP-Seq_LS180_Human0.67006512
125CJUN_26792858_Chip-Seq_BT549_Human0.66782830
126KAP1_22055183_ChIP-Seq_ESCs_Mouse0.65981220
127RARA_24833708_ChIP-Seq_LIVER_Mouse0.63064797
128TCF4_18268006_ChIP-ChIP_LS174T_Human0.62341078
129AUTS2_25519132_ChIP-Seq_293T-REX_Human0.61771998
130GATA2_21666600_ChIP-Seq_HMVEC_Human0.60944191
131CEBPB_22108803_ChIP-Seq_LS180_Human0.60367372
132STAT3_1855785_ChIP-Seq_MESCs_Mouse0.59525081
133LXR_22292898_ChIP-Seq_THP-1_Human0.58104774
134GATA1_19941826_ChIP-Seq_K562_Human0.56834964

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.94220515
2MP0002139_abnormal_hepatobiliary_system6.75300351
3MP0005085_abnormal_gallbladder_physiolo5.79908135
4MP0005365_abnormal_bile_salt5.34518964
5MP0003941_abnormal_skin_development4.57473753
6MP0008875_abnormal_xenobiotic_pharmacok4.55764115
7MP0003806_abnormal_nucleotide_metabolis3.74158653
8MP0003252_abnormal_bile_duct3.67066282
9MP0001666_abnormal_nutrient_absorption3.41460287
10MP0010329_abnormal_lipoprotein_level3.15606854
11MP0009840_abnormal_foam_cell2.89619885
12MP0010234_abnormal_vibrissa_follicle2.81666817
13MP0010352_gastrointestinal_tract_polyps2.79148858
14MP0005409_darkened_coat_color2.59846753
15MP0005083_abnormal_biliary_tract2.58163381
16MP0002254_reproductive_system_inflammat2.56966461
17MP0000762_abnormal_tongue_morphology2.42339214
18MP0005332_abnormal_amino_acid2.22720216
19MP0004019_abnormal_vitamin_homeostasis2.11196592
20MP0004264_abnormal_extraembryonic_tissu2.06388427
21MP0010771_integument_phenotype2.02973227
22MP0003705_abnormal_hypodermis_morpholog1.91496242
23MP0003191_abnormal_cellular_cholesterol1.86178380
24MP0003195_calcinosis1.85837444
25MP0000609_abnormal_liver_physiology1.85580735
26MP0004381_abnormal_hair_follicle1.80363067
27MP0002118_abnormal_lipid_homeostasis1.74216385
28MP0003868_abnormal_feces_composition1.66396599
29MP0002138_abnormal_hepatobiliary_system1.64338968
30MP0005319_abnormal_enzyme/_coenzyme1.62976315
31MP0003890_abnormal_embryonic-extraembry1.48783372
32MP0005377_hearing/vestibular/ear_phenot1.35966061
33MP0003878_abnormal_ear_physiology1.35966061
34MP0002796_impaired_skin_barrier1.34708491
35MP0009643_abnormal_urine_homeostasis1.32276196
36MP0003315_abnormal_perineum_morphology1.31495082
37MP0004885_abnormal_endolymph1.29999205
38MP0000579_abnormal_nail_morphology1.29122469
39MP0005451_abnormal_body_composition1.26935024
40MP0009931_abnormal_skin_appearance1.25866297
41MP0001191_abnormal_skin_condition1.18225253
42MP0009697_abnormal_copulation1.16996981
43MP0009053_abnormal_anal_canal1.14428909
44MP0002234_abnormal_pharynx_morphology1.12413461
45MP0008004_abnormal_stomach_pH1.12252561
46MP0000647_abnormal_sebaceous_gland1.12114041
47MP0003183_abnormal_peptide_metabolism1.10766020
48MP0000367_abnormal_coat/_hair1.09806620
49MP0005584_abnormal_enzyme/coenzyme_acti1.09627970
50MP0001764_abnormal_homeostasis1.04572833
51MP0002098_abnormal_vibrissa_morphology1.03583585
52MP0003011_delayed_dark_adaptation1.02163825
53MP0003453_abnormal_keratinocyte_physiol1.00545550
54MP0010678_abnormal_skin_adnexa0.99691621
55MP0000462_abnormal_digestive_system0.98295950
56MP0000627_abnormal_mammary_gland0.98000820
57MP0000598_abnormal_liver_morphology0.95121244
58MP0002837_dystrophic_cardiac_calcinosis0.94120129
59MP0009384_cardiac_valve_regurgitation0.93983839
60MP0000467_abnormal_esophagus_morphology0.92176233
61MP0003186_abnormal_redox_activity0.90162646
62MP0005636_abnormal_mineral_homeostasis0.86609462
63MP0000678_abnormal_parathyroid_gland0.84885969
64MP0003300_gastrointestinal_ulcer0.83168159
65MP0002060_abnormal_skin_morphology0.82842564
66MP0010368_abnormal_lymphatic_system0.82429399
67MP0000537_abnormal_urethra_morphology0.80949336
68MP0005408_hypopigmentation0.80610395
69MP0009764_decreased_sensitivity_to0.78900261
70MP0001873_stomach_inflammation0.77687550
71MP0000538_abnormal_urinary_bladder0.76650855
72MP0005248_abnormal_Harderian_gland0.74759387
73MP0006054_spinal_hemorrhage0.74132821
74MP0001851_eye_inflammation0.73088101
75MP0009642_abnormal_blood_homeostasis0.71165982
76MP0001188_hyperpigmentation0.70434116
77MP0002111_abnormal_tail_morphology0.69744448
78MP0009763_increased_sensitivity_to0.69028591
79MP0000604_amyloidosis0.68503558
80MP0003045_fibrosis0.66479617
81MP0001765_abnormal_ion_homeostasis0.66299312
82MP0004957_abnormal_blastocyst_morpholog0.66183456
83MP0002697_abnormal_eye_size0.65920068
84MP0002078_abnormal_glucose_homeostasis0.65864097
85MP0005084_abnormal_gallbladder_morpholo0.65628111
86MP0001216_abnormal_epidermal_layer0.65416179
87MP0005220_abnormal_exocrine_pancreas0.65041901
88MP0003566_abnormal_cell_adhesion0.64618216
89MP0002876_abnormal_thyroid_physiology0.64168361
90MP0001849_ear_inflammation0.63651966
91MP0005647_abnormal_sex_gland0.63532390
92MP0002009_preneoplasia0.63508398
93MP0005023_abnormal_wound_healing0.63338191
94MP0004130_abnormal_muscle_cell0.62889998
95MP0001663_abnormal_digestive_system0.62587126
96MP0008260_abnormal_autophagy0.62441786
97MP0005330_cardiomyopathy0.62341916
98MP0001756_abnormal_urination0.62251360
99MP0004185_abnormal_adipocyte_glucose0.62174752
100MP0005275_abnormal_skin_tensile0.62164609
101MP0005266_abnormal_metabolism0.62101967
102MP0005381_digestive/alimentary_phenotyp0.62034917
103MP0005376_homeostasis/metabolism_phenot0.61442985
104MP0010155_abnormal_intestine_physiology0.61298944
105MP0000566_synostosis0.61276531
106MP0003656_abnormal_erythrocyte_physiolo0.60931341
107MP0003755_abnormal_palate_morphology0.60909443
108MP0005501_abnormal_skin_physiology0.60318730
109MP0000377_abnormal_hair_follicle0.60210806
110MP0000383_abnormal_hair_follicle0.59596543
111MP0001664_abnormal_digestion0.58700926
112MP0008469_abnormal_protein_level0.58650541
113MP0005257_abnormal_intraocular_pressure0.57404095
114MP0002006_tumorigenesis0.57318126
115MP0002282_abnormal_trachea_morphology0.57270551
116MP0000465_gastrointestinal_hemorrhage0.57088862
117MP0005666_abnormal_adipose_tissue0.55944076
118MP0000477_abnormal_intestine_morphology0.55740873
119MP0000427_abnormal_hair_cycle0.55711319
120MP0005448_abnormal_energy_balance0.54395496
121MP0000470_abnormal_stomach_morphology0.54113293
122MP0006036_abnormal_mitochondrial_physio0.53454549
123MP0000490_abnormal_crypts_of0.53162018
124MP0004782_abnormal_surfactant_physiolog0.52382807
125MP0005076_abnormal_cell_differentiation0.52374559
126MP0001346_abnormal_lacrimal_gland0.52282084
127MP0003937_abnormal_limbs/digits/tail_de0.52035489
128MP0002136_abnormal_kidney_physiology0.51993225
129MP0002086_abnormal_extraembryonic_tissu0.51992084
130MP0004043_abnormal_pH_regulation0.51826650
131MP0000432_abnormal_head_morphology0.51356635
132MP0005187_abnormal_penis_morphology0.50458529
133MP0001784_abnormal_fluid_regulation0.49789063
134MP0004272_abnormal_basement_membrane0.49371537
135MP0001881_abnormal_mammary_gland0.49026301
136MP0000613_abnormal_salivary_gland0.48758894
137MP0009765_abnormal_xenobiotic_induced0.48469827
138MP0005334_abnormal_fat_pad0.48247334
139MP0004947_skin_inflammation0.48085859
140MP0002971_abnormal_brown_adipose0.47756374
141MP0006138_congestive_heart_failure0.46519740
142MP0005165_increased_susceptibility_to0.46454193
143MP0004197_abnormal_fetal_growth/weight/0.45959464
144MP0003638_abnormal_response/metabolism_0.44699501
145MP0002166_altered_tumor_susceptibility0.42416541
146MP0001485_abnormal_pinna_reflex0.42098127
147MP0003119_abnormal_digestive_system0.41826307
148MP0002084_abnormal_developmental_patter0.40888384
149MP0002896_abnormal_bone_mineralization0.39867041
150MP0003693_abnormal_embryo_hatching0.39635142
151MP0002233_abnormal_nose_morphology0.37571727
152MP0009780_abnormal_chondrocyte_physiolo0.37532465
153MP0003936_abnormal_reproductive_system0.36684676

Predicted human phenotypes

RankGene SetZ-score
1Palmoplantar hyperkeratosis (HP:0000972)6.82509858
2Intrahepatic cholestasis (HP:0001406)6.73733553
3Palmar hyperkeratosis (HP:0010765)6.54391967
4Deep venous thrombosis (HP:0002625)6.07622331
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.05460063
6Hypobetalipoproteinemia (HP:0003563)6.01355649
7Thick nail (HP:0001805)5.77607625
8Abnormality of aromatic amino acid family metabolism (HP:0004338)5.69698006
9Xanthomatosis (HP:0000991)5.46007672
10Prolonged partial thromboplastin time (HP:0003645)4.96536455
11Abnormality of secondary sexual hair (HP:0009888)4.70163220
12Abnormality of the axillary hair (HP:0100134)4.70163220
13Oral leukoplakia (HP:0002745)4.65764404
14Hypolipoproteinemia (HP:0010981)4.64495369
15Abnormality of glutamine family amino acid metabolism (HP:0010902)4.63768214
16Pili torti (HP:0003777)4.43601750
17Hypotrichosis (HP:0001006)4.33950362
18* Right ventricular cardiomyopathy (HP:0011663)4.29613845
19Hypoglycemic coma (HP:0001325)4.28861204
20Hyperlipoproteinemia (HP:0010980)4.26648376
21Hyperammonemia (HP:0001987)4.25310080
22Nail dystrophy (HP:0008404)4.23453671
23Fat malabsorption (HP:0002630)4.18088430
24Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.15488739
25Congenital ichthyosiform erythroderma (HP:0007431)4.12834908
26Epidermoid cyst (HP:0200040)4.12436171
27Atrophic scars (HP:0001075)4.05763124
28Complement deficiency (HP:0004431)4.00852373
29Conjugated hyperbilirubinemia (HP:0002908)3.98996204
30Hypoalphalipoproteinemia (HP:0003233)3.97838944
31Erythroderma (HP:0001019)3.79560142
32Corneal erosion (HP:0200020)3.72478026
33Hyperglycinuria (HP:0003108)3.72320785
34Abnormality of the common coagulation pathway (HP:0010990)3.69446409
35Sparse eyelashes (HP:0000653)3.66607312
36Abnormality of sulfur amino acid metabolism (HP:0004339)3.63712637
37* Woolly hair (HP:0002224)3.63619697
38Ketosis (HP:0001946)3.62541548
39Abnormal hair laboratory examination (HP:0003328)3.59056476
40Abnormal blistering of the skin (HP:0008066)3.55910692
41Abnormality of aspartate family amino acid metabolism (HP:0010899)3.53706751
42Lip pit (HP:0100267)3.43811335
43Absent eyelashes (HP:0000561)3.40538575
44Abnormality of glycine metabolism (HP:0010895)3.40271335
45Abnormality of serine family amino acid metabolism (HP:0010894)3.40271335
46Ectropion (HP:0000656)3.35864423
47Hypercholesterolemia (HP:0003124)3.33134929
48Hyperglycinemia (HP:0002154)3.32665734
49Abnormality of the intrinsic pathway (HP:0010989)3.30345800
50Ridged nail (HP:0001807)3.28946465
51Abnormality of fatty-acid metabolism (HP:0004359)3.28011887
52Joint hemorrhage (HP:0005261)3.27257136
53Hypoplastic labia majora (HP:0000059)3.16843406
54Abnormality of methionine metabolism (HP:0010901)3.16324793
55Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.13493213
56Malnutrition (HP:0004395)3.06772505
57Ketoacidosis (HP:0001993)3.06177408
58* Palmoplantar keratoderma (HP:0000982)3.05295718
59Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.03740322
60Increased IgE level (HP:0003212)2.99445448
61Abnormality of the salivary glands (HP:0010286)2.98363030
62Sparse scalp hair (HP:0002209)2.96753780
63Hypoplasia of dental enamel (HP:0006297)2.96451305
64Hyperbilirubinemia (HP:0002904)2.96348022
65Abnormality of complement system (HP:0005339)2.91430239
66Hydroxyprolinuria (HP:0003080)2.91244782
67Abnormality of proline metabolism (HP:0010907)2.91244782
68Amelogenesis imperfecta (HP:0000705)2.91157151
69Ileus (HP:0002595)2.89341006
70Abnormality of purine metabolism (HP:0004352)2.83333547
71Abnormality of the labia majora (HP:0012881)2.82164489
72Abnormality of nucleobase metabolism (HP:0010932)2.81129567
73Hepatocellular carcinoma (HP:0001402)2.80385667
74Esophageal varix (HP:0002040)2.79744484
75Acanthocytosis (HP:0001927)2.78659865
76Absent hair (HP:0002298)2.78100742
77Parakeratosis (HP:0001036)2.77029575
78Abnormality of pyrimidine metabolism (HP:0004353)2.76721607
79Blepharitis (HP:0000498)2.76643828
80Steatorrhea (HP:0002570)2.74624501
81Natal tooth (HP:0000695)2.71323597
82Vascular calcification (HP:0004934)2.70208993
83Hypohidrosis (HP:0000966)2.68167380
84Erythema (HP:0010783)2.66907561
85Hypoglycemic seizures (HP:0002173)2.63763140
86Metabolic acidosis (HP:0001942)2.63429406
87Skin nodule (HP:0200036)2.61915203
88Pterygium (HP:0001059)2.61644578
89Abnormality of dicarboxylic acid metabolism (HP:0010995)2.58868901
90Dicarboxylic aciduria (HP:0003215)2.58868901
91Abnormality of placental membranes (HP:0011409)2.56644405
92Amniotic constriction ring (HP:0009775)2.56644405
93Dehydration (HP:0001944)2.51077767
94Advanced eruption of teeth (HP:0006288)2.48899456
95Curly hair (HP:0002212)2.44694798
96Popliteal pterygium (HP:0009756)2.44661433
97Myocardial infarction (HP:0001658)2.43593189
98Lethargy (HP:0001254)2.42651060
99Cardiovascular calcification (HP:0011915)2.42086448
100Selective tooth agenesis (HP:0001592)2.42055524
101Hyperglycemia (HP:0003074)2.40939347
102Spontaneous abortion (HP:0005268)2.39948982
103Ventricular tachycardia (HP:0004756)2.39397528
104Hyperactive renin-angiotensin system (HP:0000841)2.37935175
105Onycholysis (HP:0001806)2.37327308
106Abnormal gallbladder morphology (HP:0012437)2.34404393
107Cholelithiasis (HP:0001081)2.32995494
108Late onset (HP:0003584)2.31755877
109Flat acetabular roof (HP:0003180)2.31429485
110Hyperinsulinemic hypoglycemia (HP:0000825)2.30580200
111Aplasia cutis congenita (HP:0001057)2.24763979
112Generalized aminoaciduria (HP:0002909)2.23495660
113Abnormal gallbladder physiology (HP:0012438)2.23033154
114Cholecystitis (HP:0001082)2.23033154
115Gout (HP:0001997)2.21653711
116Abnormality of serum amino acid levels (HP:0003112)2.21517011
117Anonychia (HP:0001798)2.20164594
118Spastic diplegia (HP:0001264)2.18850907
119Delayed CNS myelination (HP:0002188)2.17598692
120Dry hair (HP:0011359)2.17471857
121Labial hypoplasia (HP:0000066)2.17114513
122Laryngomalacia (HP:0001601)2.12276540
123Carious teeth (HP:0000670)2.11904370
124Cerebral edema (HP:0002181)2.10736277
125Abnormal cartilage morphology (HP:0002763)2.07349156
126Abnormality of the gastric mucosa (HP:0004295)2.06939388
127Pancreatitis (HP:0001733)2.06264250
128Ankyloglossia (HP:0010296)2.06017770
129Abnormality of urine glucose concentration (HP:0011016)2.03457112
130Glycosuria (HP:0003076)2.03457112
131Hypochromic microcytic anemia (HP:0004840)2.00743821
132Abnormality of vitamin metabolism (HP:0100508)2.00487798
133Systemic lupus erythematosus (HP:0002725)2.00476848
134Abdominal distention (HP:0003270)2.00334999
135Abnormality of nail color (HP:0100643)10.0644224
136Alopecia of scalp (HP:0002293)1.98744240
137Hemorrhage of the eye (HP:0011885)1.98677566
138Hypoplastic female external genitalia (HP:0012815)1.98440394
139Follicular hyperkeratosis (HP:0007502)1.97733660
140Symptomatic seizures (HP:0011145)1.97299028
141Plantar hyperkeratosis (HP:0007556)1.95915830
142Poikilocytosis (HP:0004447)1.95599733
143Myoglobinuria (HP:0002913)1.92136959
144Proximal tubulopathy (HP:0000114)1.90912697
145Irritability (HP:0000737)1.90460934
146Oligodontia (HP:0000677)1.89189350
147Vomiting (HP:0002013)1.88881724
148Hyperuricemia (HP:0002149)1.88402013
149Increased purine levels (HP:0004368)1.88402013
150Sensorimotor neuropathy (HP:0007141)1.87200918
151Milia (HP:0001056)1.86929322
152Fragile skin (HP:0001030)1.85906486
153Pustule (HP:0200039)1.84619011
154Taurodontia (HP:0000679)1.84008082
155Abnormality of permanent molar morphology (HP:0011071)1.84008082
156Abnormality of the dental root (HP:0006486)1.84008082
157Abnormality of the gallbladder (HP:0005264)1.83991880
158Abnormality of transition element cation homeostasis (HP:0011030)1.82262317
159Hyperhidrosis (HP:0000975)1.81672143
160Pigmentary retinal degeneration (HP:0001146)1.81429550
161Renal cortical cysts (HP:0000803)1.81064373
162Fragile nails (HP:0001808)1.81043784
163Esophageal atresia (HP:0002032)1.80624349
164Glomerulonephritis (HP:0000099)1.79902288
165Furrowed tongue (HP:0000221)1.76967330
166Neonatal onset (HP:0003623)1.76557752
167Autoamputation (HP:0001218)1.76308573
168Pruritus (HP:0000989)1.73507753
169Abnormality of the dental pulp (HP:0006479)1.66409901
170Abnormality of small intestinal villus morphology (HP:0011472)1.65702915
171Villous atrophy (HP:0011473)1.65702915
172Septate vagina (HP:0001153)1.64668974
173Abnormality of the fingernails (HP:0001231)1.64647257
174Abnormality of molar (HP:0011077)1.64236228
175Abnormality of molar morphology (HP:0011070)1.64236228
176Gangrene (HP:0100758)1.64000374
177Cheilitis (HP:0100825)1.62071143
178Premature loss of primary teeth (HP:0006323)1.61569653
179Neonatal death (HP:0003811)1.58462154
180Xerostomia (HP:0000217)1.57838486
181Slow-growing hair (HP:0002217)1.56866405
182Abnormality of hair growth rate (HP:0011363)1.56866405
183Abnormal tarsal ossification (HP:0008369)1.55631945
184Multifactorial inheritance (HP:0001426)1.54865874
185Skin pits (HP:0100276)1.54668540
186Abnormality of chloride homeostasis (HP:0011422)1.54458061
187Abnormality of the distal phalanx of the thumb (HP:0009617)1.52866706

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.50905564
2BCKDK3.82069792
3ACVR1B3.50227726
4MST1R3.28366878
5ERN13.05855155
6LMTK23.01803720
7EPHA22.82823822
8LATS12.78065556
9ERBB42.64968914
10PKN22.63283727
11FGFR42.60023086
12SIK12.57802566
13PTK62.33736357
14INSRR2.14783874
15LATS22.09829246
16TGFBR12.01110596
17CDK122.01015006
18MST41.96208300
19TRIB31.92042420
20RIPK11.82728565
21PIK3CA1.75904859
22STK38L1.71770479
23MAP2K21.71007215
24TAOK31.70446211
25MYLK1.67008723
26STK391.66475101
27MAP3K31.65301362
28MAP3K121.59224868
29MAP3K21.55534131
30EPHB21.54478036
31FER1.45027774
32NLK1.44377829
33PRKG21.41203273
34MET1.40724852
35TTN1.34124701
36PTK21.32579104
37PBK1.31836613
38ERBB21.25526946
39MAP3K101.23578675
40NUAK11.22102145
41MAP3K91.16405156
42MAP3K71.15692430
43FLT31.15400190
44BCR1.14649904
45EPHB11.14139344
46MAP3K61.14131790
47PIK3CG1.11597404
48MAPK111.10538958
49OXSR11.09208439
50NEK91.08206534
51OBSCN1.06614785
52ERBB31.06421405
53MAP2K11.05263074
54TYK21.04639563
55TNIK1.04321513
56PRKAA21.00931805
57CASK0.99816041
58PDK40.99648764
59PDK30.99648764
60CAMK1D0.98664999
61RPS6KB20.98614494
62CAMK1G0.93524441
63TRIM280.91511541
64MATK0.85451693
65PAK30.85320725
66WNK10.84999459
67EIF2AK30.83738594
68MAPK150.82182449
69STK380.81901485
70STK30.78851609
71BRD40.78317141
72GRK60.77228383
73YES10.76892665
74FGFR20.72395471
75AKT30.71112989
76TESK10.71064285
77MAP2K60.70778350
78MAP2K40.69768899
79PDK20.69540684
80EEF2K0.69528584
81CDK60.69507998
82EPHA30.68293739
83GRK10.66972970
84MAPKAPK30.66339534
85PDGFRA0.66278570
86NEK10.65391729
87JAK20.63753228
88CAMK2G0.62742139
89BMPR1B0.59460243
90FGR0.58447039
91DYRK1B0.57375002
92TBK10.56351501
93KDR0.56313502
94MAP2K30.55896538
95TRPM70.55042720
96PRKCE0.54779060
97SIK30.54294506
98PRKAA10.54085024
99NME10.52650505
100MAP3K10.52636671
101STK100.50923957
102MKNK10.50659783
103GSK3A0.50320594
104LRRK20.49912786
105KSR20.48113793
106BRSK20.47771191
107STK240.46730013
108DAPK20.46646484
109JAK10.46050472
110MAP3K110.45775941
111MKNK20.45690184
112MELK0.45002599
113CAMK2D0.43325351
114FGFR30.42835678
115ABL20.42509960
116RET0.42102633
117TGFBR20.41501159
118TAOK10.41463789
119PRKACG0.39625737
120PDGFRB0.39334607
121FGFR10.39220230
122PAK40.38563708
123TAF10.38390478
124PAK20.38083509
125TTK0.37995528
126PDPK10.37308014
127SGK2230.36722279
128SGK4940.36722279
129CSK0.36291307
130MAP3K80.36231203
131MTOR0.35912962
132IRAK10.35477961
133ROCK10.35335961
134DMPK0.35017466
135NTRK10.34595770
136CDC42BPA0.34126553
137PLK40.34065252
138PRKD10.33963418
139BMX0.33943541
140PRKCI0.32990272
141NEK60.32868958
142TIE10.32547908
143SGK30.29302012
144IGF1R0.23273389
145RPS6KA40.21900392
146DYRK30.20036502
147ARAF0.19404075
148RPS6KB10.19039894

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.55378802
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.41478445
3Nitrogen metabolism_Homo sapiens_hsa009103.20352111
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.06830220
5Arginine biosynthesis_Homo sapiens_hsa002202.75484136
6Fatty acid degradation_Homo sapiens_hsa000712.64891674
7Tryptophan metabolism_Homo sapiens_hsa003802.56652905
8Sphingolipid metabolism_Homo sapiens_hsa006002.49991376
9Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.42337354
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.32590109
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.29865407
12Sulfur metabolism_Homo sapiens_hsa009202.27973210
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.27182357
14Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.19396701
15Complement and coagulation cascades_Homo sapiens_hsa046102.18303874
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.16560829
17Fat digestion and absorption_Homo sapiens_hsa049752.14381036
18Histidine metabolism_Homo sapiens_hsa003402.11481785
19Chemical carcinogenesis_Homo sapiens_hsa052042.10741965
20Caffeine metabolism_Homo sapiens_hsa002321.97135846
21Propanoate metabolism_Homo sapiens_hsa006401.94496666
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.92953279
23Butanoate metabolism_Homo sapiens_hsa006501.91938152
24Ether lipid metabolism_Homo sapiens_hsa005651.91872525
25PPAR signaling pathway_Homo sapiens_hsa033201.87281001
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.74533492
27Fatty acid metabolism_Homo sapiens_hsa012121.74244098
28Peroxisome_Homo sapiens_hsa041461.72807049
29beta-Alanine metabolism_Homo sapiens_hsa004101.71679837
30Bile secretion_Homo sapiens_hsa049761.68053412
31Retinol metabolism_Homo sapiens_hsa008301.67841262
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.67640413
33Starch and sucrose metabolism_Homo sapiens_hsa005001.66938354
34Phenylalanine metabolism_Homo sapiens_hsa003601.64815215
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.49689489
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.48048411
37Pyruvate metabolism_Homo sapiens_hsa006201.44057607
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.41418963
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.41236852
40Selenocompound metabolism_Homo sapiens_hsa004501.40727494
41Tyrosine metabolism_Homo sapiens_hsa003501.37227099
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.34842177
43Vitamin digestion and absorption_Homo sapiens_hsa049771.32466642
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.29544405
45Carbon metabolism_Homo sapiens_hsa012001.28503616
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25498406
47Small cell lung cancer_Homo sapiens_hsa052221.20003524
48Folate biosynthesis_Homo sapiens_hsa007901.19706520
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.18465051
50Staphylococcus aureus infection_Homo sapiens_hsa051501.15856909
51Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.15297009
52ABC transporters_Homo sapiens_hsa020101.13496048
53Cyanoamino acid metabolism_Homo sapiens_hsa004601.12413083
54Biosynthesis of amino acids_Homo sapiens_hsa012301.10062413
55Fatty acid elongation_Homo sapiens_hsa000621.09755293
56Glutathione metabolism_Homo sapiens_hsa004801.08126086
57Dorso-ventral axis formation_Homo sapiens_hsa043201.07519125
58Cysteine and methionine metabolism_Homo sapiens_hsa002701.04377903
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.04158739
60Arginine and proline metabolism_Homo sapiens_hsa003301.00288996
61TGF-beta signaling pathway_Homo sapiens_hsa043500.94397775
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88230960
63Steroid biosynthesis_Homo sapiens_hsa001000.87830995
64Hippo signaling pathway_Homo sapiens_hsa043900.85045427
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.84462630
66Leukocyte transendothelial migration_Homo sapiens_hsa046700.84312357
67Glycerolipid metabolism_Homo sapiens_hsa005610.82121084
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79913773
69Galactose metabolism_Homo sapiens_hsa000520.79541878
70Lysine degradation_Homo sapiens_hsa003100.76294532
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74702411
72Basal cell carcinoma_Homo sapiens_hsa052170.72896202
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72303786
74Sulfur relay system_Homo sapiens_hsa041220.71298639
75Focal adhesion_Homo sapiens_hsa045100.71270790
76Proteoglycans in cancer_Homo sapiens_hsa052050.70598817
77Renin secretion_Homo sapiens_hsa049240.69276987
78Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67090712
79GnRH signaling pathway_Homo sapiens_hsa049120.66372103
80p53 signaling pathway_Homo sapiens_hsa041150.63767364
81Fructose and mannose metabolism_Homo sapiens_hsa000510.62842753
82Endometrial cancer_Homo sapiens_hsa052130.61215795
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59420067
84Pentose phosphate pathway_Homo sapiens_hsa000300.59032649
85MicroRNAs in cancer_Homo sapiens_hsa052060.58821198
86Inositol phosphate metabolism_Homo sapiens_hsa005620.57837794
87Mineral absorption_Homo sapiens_hsa049780.56947966
88Hedgehog signaling pathway_Homo sapiens_hsa043400.55415405
89Ovarian steroidogenesis_Homo sapiens_hsa049130.53805440
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51674581
91Linoleic acid metabolism_Homo sapiens_hsa005910.51322189
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49719338
93Choline metabolism in cancer_Homo sapiens_hsa052310.49217700
94Pathways in cancer_Homo sapiens_hsa052000.47459541
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44040542
96Fatty acid biosynthesis_Homo sapiens_hsa000610.42791421
97Prostate cancer_Homo sapiens_hsa052150.42510368
98Metabolic pathways_Homo sapiens_hsa011000.42407231
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40585630
100Insulin resistance_Homo sapiens_hsa049310.39539820
101Toxoplasmosis_Homo sapiens_hsa051450.38623002
102Renin-angiotensin system_Homo sapiens_hsa046140.37742521
103Notch signaling pathway_Homo sapiens_hsa043300.35630496
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35010381
105VEGF signaling pathway_Homo sapiens_hsa043700.34188308
106Phototransduction_Homo sapiens_hsa047440.32062351
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31822861
108ErbB signaling pathway_Homo sapiens_hsa040120.31669557
109Axon guidance_Homo sapiens_hsa043600.30881675
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.30494823
111Renal cell carcinoma_Homo sapiens_hsa052110.30399739
112Wnt signaling pathway_Homo sapiens_hsa043100.27905499
113One carbon pool by folate_Homo sapiens_hsa006700.26442598
114Vitamin B6 metabolism_Homo sapiens_hsa007500.25322882
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.21762612
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.21286536
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.18969716
118Protein digestion and absorption_Homo sapiens_hsa049740.18437958
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.14288996
120Glucagon signaling pathway_Homo sapiens_hsa049220.10755449
121Arachidonic acid metabolism_Homo sapiens_hsa005900.10577430
122Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.08622019
123Prion diseases_Homo sapiens_hsa050200.07625329
124AMPK signaling pathway_Homo sapiens_hsa041520.07179597
125Tight junction_Homo sapiens_hsa045300.07063120
126Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.06915517
127Thyroid hormone synthesis_Homo sapiens_hsa049180.06748974
128Bladder cancer_Homo sapiens_hsa052190.06259516
129Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.04760344
130Adherens junction_Homo sapiens_hsa045200.03813917
131* Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.01647825
132Thyroid cancer_Homo sapiens_hsa05216-0.1099953
133Pancreatic secretion_Homo sapiens_hsa04972-0.0807352
134ECM-receptor interaction_Homo sapiens_hsa04512-0.0480168
135Insulin signaling pathway_Homo sapiens_hsa04910-0.0360535
136Hepatitis C_Homo sapiens_hsa05160-0.0285784
137Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0171339
138Amoebiasis_Homo sapiens_hsa05146-0.0030896

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