DRP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the dystrophin family of proteins perform a critical role in the maintenance of membrane-associated complexes at points of intercellular contact in vertebrate cells. The protein encoded by this gene is predicted to resemble certain short C-terminal isoforms of dystrophin and dystrophin-related protein 1 (DRP1 or utrophin). DRP2 is expressed principally in the brain and spinal cord. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.49119914
2regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.32323653
3vocalization behavior (GO:0071625)5.26746864
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.18302302
5neuron cell-cell adhesion (GO:0007158)5.02945912
6protein localization to synapse (GO:0035418)4.93120383
7locomotory exploration behavior (GO:0035641)4.87301204
8neuronal action potential propagation (GO:0019227)4.86613186
9synaptic vesicle exocytosis (GO:0016079)4.82978522
10regulation of glutamate receptor signaling pathway (GO:1900449)4.80902161
11synaptic vesicle maturation (GO:0016188)4.76876411
12ionotropic glutamate receptor signaling pathway (GO:0035235)4.74121949
13glutamate secretion (GO:0014047)4.72334674
14synaptic vesicle docking involved in exocytosis (GO:0016081)4.62735570
15positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.61782648
16regulation of synaptic vesicle exocytosis (GO:2000300)4.54873605
17L-amino acid import (GO:0043092)4.48596351
18glutamate receptor signaling pathway (GO:0007215)4.28873747
19amino acid import (GO:0043090)4.18645700
20cerebellar granule cell differentiation (GO:0021707)4.17930011
21regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.17793721
22synaptic transmission, glutamatergic (GO:0035249)4.17383732
23neurotransmitter-gated ion channel clustering (GO:0072578)4.05437295
24regulation of neuronal synaptic plasticity (GO:0048168)4.05385926
25regulation of long-term neuronal synaptic plasticity (GO:0048169)4.04697473
26regulation of synaptic vesicle transport (GO:1902803)4.03329151
27exploration behavior (GO:0035640)4.01128556
28neuron recognition (GO:0008038)4.00627804
29regulation of synapse structural plasticity (GO:0051823)4.00492859
30dendritic spine morphogenesis (GO:0060997)3.99321228
31postsynaptic membrane organization (GO:0001941)3.96654830
32proline transport (GO:0015824)3.96192128
33layer formation in cerebral cortex (GO:0021819)3.94687901
34neuron-neuron synaptic transmission (GO:0007270)3.94077866
35neurotransmitter secretion (GO:0007269)3.93815042
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.93142549
37cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.85186286
38axonal fasciculation (GO:0007413)3.80369796
39gamma-aminobutyric acid transport (GO:0015812)3.72033836
40regulation of excitatory postsynaptic membrane potential (GO:0060079)3.71599937
41positive regulation of dendritic spine morphogenesis (GO:0061003)3.71536596
42regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.71137534
43negative regulation of dendrite morphogenesis (GO:0050774)3.70723376
44regulation of voltage-gated calcium channel activity (GO:1901385)3.69478282
45presynaptic membrane assembly (GO:0097105)3.69336164
46potassium ion homeostasis (GO:0055075)3.65303340
47regulation of postsynaptic membrane potential (GO:0060078)3.58465723
48auditory behavior (GO:0031223)3.47877837
49regulation of synaptic transmission, glutamatergic (GO:0051966)3.46499882
50long-term memory (GO:0007616)3.46492558
51cellular potassium ion homeostasis (GO:0030007)3.46067054
52regulation of dendritic spine morphogenesis (GO:0061001)3.44465457
53regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.43428094
54transmission of nerve impulse (GO:0019226)3.41826153
55regulation of synapse maturation (GO:0090128)3.41432609
56negative regulation of synaptic transmission, GABAergic (GO:0032229)3.41285719
57presynaptic membrane organization (GO:0097090)3.39877662
58regulation of synaptic plasticity (GO:0048167)3.39647437
59positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.39025676
60positive regulation of membrane potential (GO:0045838)3.38954113
61cell migration in hindbrain (GO:0021535)3.36064697
62cerebellar Purkinje cell differentiation (GO:0021702)3.34928231
63dendrite morphogenesis (GO:0048813)3.33938036
64response to auditory stimulus (GO:0010996)3.31572758
65regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.31455268
66membrane depolarization during action potential (GO:0086010)3.30662028
67gamma-aminobutyric acid signaling pathway (GO:0007214)3.29416699
68synaptic vesicle endocytosis (GO:0048488)3.28216501
69long-term synaptic potentiation (GO:0060291)3.26732127
70positive regulation of neurotransmitter secretion (GO:0001956)3.26237221
71G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.25962856
72neurotransmitter transport (GO:0006836)3.24415120
73membrane depolarization (GO:0051899)3.23281904
74positive regulation of synapse maturation (GO:0090129)3.22961895
75negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.22627847
76regulation of ARF protein signal transduction (GO:0032012)3.22392945
77positive regulation of synaptic transmission, GABAergic (GO:0032230)3.21169178
78regulation of neurotransmitter secretion (GO:0046928)3.19962479
79response to histamine (GO:0034776)3.18544560
80prepulse inhibition (GO:0060134)3.15313586
81axon ensheathment in central nervous system (GO:0032291)3.15184941
82central nervous system myelination (GO:0022010)3.15184941
83positive regulation of neurotransmitter transport (GO:0051590)3.14969634
84potassium ion import (GO:0010107)3.12773745
85regulation of vesicle fusion (GO:0031338)3.12578098
86innervation (GO:0060384)3.10161204
87membrane hyperpolarization (GO:0060081)3.09613858
88regulation of dendritic spine development (GO:0060998)3.08374399
89regulation of respiratory system process (GO:0044065)3.05534808
90central nervous system projection neuron axonogenesis (GO:0021952)3.05054461
91activation of protein kinase A activity (GO:0034199)3.03517610
92neuromuscular synaptic transmission (GO:0007274)3.03483280
93neuromuscular process controlling balance (GO:0050885)3.03406060
94learning (GO:0007612)3.02788163
95neuromuscular process (GO:0050905)3.01846673
96neuronal ion channel clustering (GO:0045161)3.01549310
97acidic amino acid transport (GO:0015800)3.00428803
98positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.00050756
99regulation of neurotransmitter levels (GO:0001505)2.99374887
100positive regulation of synapse assembly (GO:0051965)2.99281145
101synapse assembly (GO:0007416)2.98697180
102behavioral fear response (GO:0001662)2.98532050
103behavioral defense response (GO:0002209)2.98532050
104regulation of neurotransmitter transport (GO:0051588)2.97934381
105positive regulation of dendritic spine development (GO:0060999)2.95645378
106mechanosensory behavior (GO:0007638)2.95520022
107positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.95289573
108sodium ion export (GO:0071436)2.94643048
109positive regulation of synaptic transmission (GO:0050806)2.91772677
110negative regulation of dendrite development (GO:2000171)2.91257300
111synaptic transmission (GO:0007268)2.88732978
112cellular sodium ion homeostasis (GO:0006883)2.88405843
113behavioral response to cocaine (GO:0048148)2.87318991
114regulation of synaptic transmission (GO:0050804)2.87164830
115cytoskeletal anchoring at plasma membrane (GO:0007016)2.86643120
116regulation of dendrite morphogenesis (GO:0048814)2.86061083
117dendritic spine organization (GO:0097061)2.84919795
118startle response (GO:0001964)2.84908537
119cell communication by electrical coupling (GO:0010644)2.84737687
120G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.84283665
121detection of calcium ion (GO:0005513)2.83878210
122positive regulation of dendrite development (GO:1900006)2.83843947

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.51179352
2GBX2_23144817_ChIP-Seq_PC3_Human3.75790170
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.11754193
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.07122387
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.05714407
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.75042958
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.75042958
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.66838447
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.66613960
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.62326705
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.59779013
12REST_21632747_ChIP-Seq_MESCs_Mouse2.53179740
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.52258061
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.44832890
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.44275666
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.39752039
17SUZ12_27294783_Chip-Seq_ESCs_Mouse2.25908672
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.25212627
19DROSHA_22980978_ChIP-Seq_HELA_Human2.23407734
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.23169960
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.21548901
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.99277105
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.98867592
24REST_18959480_ChIP-ChIP_MESCs_Mouse1.96350927
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.93187622
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.91534000
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.91081324
28AR_21572438_ChIP-Seq_LNCaP_Human1.87571340
29TAF15_26573619_Chip-Seq_HEK293_Human1.86745489
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.86012417
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.80822599
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68084600
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64169046
34RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.62968525
35SMAD4_21799915_ChIP-Seq_A2780_Human1.61649507
36MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.60827620
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59918399
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.58582853
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.58254733
40EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57889609
41ZFP281_18757296_ChIP-ChIP_E14_Mouse1.52369859
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.49724772
43P300_19829295_ChIP-Seq_ESCs_Human1.46424305
44RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.45383234
45ERG_21242973_ChIP-ChIP_JURKAT_Human1.44967982
46ZNF274_21170338_ChIP-Seq_K562_Hela1.43276642
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.40576894
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.36603174
49RING1B_27294783_Chip-Seq_ESCs_Mouse1.34643791
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33680245
51TRIM28_21343339_ChIP-Seq_HEK293_Human1.30484764
52SOX2_21211035_ChIP-Seq_LN229_Gbm1.30057258
53SMAD_19615063_ChIP-ChIP_OVARY_Human1.29463910
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26101182
55NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23749747
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23430077
57AR_25329375_ChIP-Seq_VCAP_Human1.23147562
58RNF2_27304074_Chip-Seq_NSC_Mouse1.22793296
59ZFP281_27345836_Chip-Seq_ESCs_Mouse1.22747826
60IGF1R_20145208_ChIP-Seq_DFB_Human1.22716981
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.21118680
62SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.20159692
63STAT3_23295773_ChIP-Seq_U87_Human1.19931409
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19217661
65AR_19668381_ChIP-Seq_PC3_Human1.19132647
66OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.17842188
67SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17534835
68RING1B_27294783_Chip-Seq_NPCs_Mouse1.17055903
69EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.16967622
70TET1_21490601_ChIP-Seq_MESCs_Mouse1.16143912
71ARNT_22903824_ChIP-Seq_MCF-7_Human1.15943947
72AHR_22903824_ChIP-Seq_MCF-7_Human1.14987756
73GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13220856
74EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.12647907
75POU3F2_20337985_ChIP-ChIP_501MEL_Human1.12388317
76WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10347148
77TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10146199
78ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09334262
79PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.08413753
80TP53_20018659_ChIP-ChIP_R1E_Mouse1.08387224
81RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.08293228
82CTNNB1_20460455_ChIP-Seq_HCT116_Human1.08205458
83TP53_16413492_ChIP-PET_HCT116_Human1.05811112
84TCF4_23295773_ChIP-Seq_U87_Human1.05124460
85P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05014772
86YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04765967
87TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04194501
88POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04194501
89UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03660994
90AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03544938
91TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03383985
92TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.03253897
93PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02973986
94CTCF_27219007_Chip-Seq_Bcells_Human1.01943903
95CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01682017
96NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01233571
97FUS_26573619_Chip-Seq_HEK293_Human1.00590893
98RUNX2_22187159_ChIP-Seq_PCA_Human1.00412408
99CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99156815
100WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.98131224
101ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98096871
102GATA1_26923725_Chip-Seq_HPCs_Mouse0.97935118
103TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97436386
104TP53_18474530_ChIP-ChIP_U2OS_Human0.97021797
105TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96303951
106DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96002783
107PRDM14_20953172_ChIP-Seq_ESCs_Human0.95918354
108VDR_22108803_ChIP-Seq_LS180_Human0.94063155
109MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93523738
110SMAD3_21741376_ChIP-Seq_ESCs_Human0.92626873
111NANOG_18555785_Chip-Seq_ESCs_Mouse0.92180740
112SMAD4_21741376_ChIP-Seq_HESCs_Human0.90011722
113KDM2B_26808549_Chip-Seq_K562_Human0.89082172
114ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.88563394
115TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88371744
116SMAD3_21741376_ChIP-Seq_HESCs_Human0.87837781
117CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.87609172
118EP300_21415370_ChIP-Seq_HL-1_Mouse0.86712515
119ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.86693604
120BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.86621836
121TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.86593077
122ER_23166858_ChIP-Seq_MCF-7_Human0.86067011
123LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83404527
124DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.81787059
125SOX9_26525672_Chip-Seq_HEART_Mouse0.81455536
126KDM2B_26808549_Chip-Seq_REH_Human0.80594957
127TP53_23651856_ChIP-Seq_MEFs_Mouse0.78277947
128SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.77732325
129DPY_21335234_ChIP-Seq_ESCs_Mouse0.76791268
130ESR2_21235772_ChIP-Seq_MCF-7_Human0.76083232

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.97040430
2MP0003880_abnormal_central_pattern4.95482554
3MP0003635_abnormal_synaptic_transmissio3.89562906
4MP0004270_analgesia3.83356748
5MP0001968_abnormal_touch/_nociception3.50843554
6MP0002063_abnormal_learning/memory/cond3.24911874
7MP0009745_abnormal_behavioral_response3.20299774
8MP0002064_seizures2.90646285
9MP0009046_muscle_twitch2.85077537
10MP0002734_abnormal_mechanical_nocicepti2.78858885
11MP0005423_abnormal_somatic_nervous2.76183226
12MP0002572_abnormal_emotion/affect_behav2.75976809
13MP0002736_abnormal_nociception_after2.66935493
14MP0002272_abnormal_nervous_system2.62057221
15MP0001486_abnormal_startle_reflex2.54529796
16MP0002735_abnormal_chemical_nociception2.45780215
17MP0002822_catalepsy2.28443782
18MP0002733_abnormal_thermal_nociception2.18306750
19MP0006276_abnormal_autonomic_nervous2.16016006
20MP0001501_abnormal_sleep_pattern2.09646596
21MP0001440_abnormal_grooming_behavior2.09512179
22MP0000778_abnormal_nervous_system2.08405229
23MP0002067_abnormal_sensory_capabilities2.07601132
24MP0001970_abnormal_pain_threshold2.03903068
25MP0004858_abnormal_nervous_system2.02457805
26MP0002184_abnormal_innervation1.84447689
27MP0002557_abnormal_social/conspecific_i1.82776710
28MP0009780_abnormal_chondrocyte_physiolo1.78384494
29MP0008569_lethality_at_weaning1.75205164
30MP0005646_abnormal_pituitary_gland1.75005471
31MP0004811_abnormal_neuron_physiology1.68746243
32MP0003329_amyloid_beta_deposits1.64130241
33MP0005386_behavior/neurological_phenoty1.63834377
34MP0004924_abnormal_behavior1.63834377
35MP0000751_myopathy1.58356209
36MP0001984_abnormal_olfaction1.55929995
37MP0000955_abnormal_spinal_cord1.51040418
38MP0003879_abnormal_hair_cell1.45258491
39MP0002882_abnormal_neuron_morphology1.42788009
40MP0005645_abnormal_hypothalamus_physiol1.42256803
41MP0001529_abnormal_vocalization1.41104836
42MP0003122_maternal_imprinting1.39553610
43MP0002066_abnormal_motor_capabilities/c1.37503644
44MP0003787_abnormal_imprinting1.37495678
45MP0000569_abnormal_digit_pigmentation1.37379218
46MP0002909_abnormal_adrenal_gland1.36033329
47MP0004145_abnormal_muscle_electrophysio1.30636095
48MP0001188_hyperpigmentation1.30233041
49MP0004885_abnormal_endolymph1.27097316
50MP0001502_abnormal_circadian_rhythm1.22923955
51MP0003633_abnormal_nervous_system1.21674072
52MP0001905_abnormal_dopamine_level1.19783912
53MP0003123_paternal_imprinting1.13493006
54MP0002152_abnormal_brain_morphology1.10323268
55MP0003631_nervous_system_phenotype1.07443207
56MP0004742_abnormal_vestibular_system1.02492423
57MP0004142_abnormal_muscle_tone1.00774533
58MP0003634_abnormal_glial_cell0.96014902
59MP0000920_abnormal_myelination0.93772727
60MP0001348_abnormal_lacrimal_gland0.90858853
61MP0002638_abnormal_pupillary_reflex0.89683992
62MP0000631_abnormal_neuroendocrine_gland0.89558858
63MP0001963_abnormal_hearing_physiology0.89211072
64MP0005409_darkened_coat_color0.88595552
65MP0010386_abnormal_urinary_bladder0.87277774
66MP0002229_neurodegeneration0.86592104
67MP0002069_abnormal_eating/drinking_beha0.84304930
68MP0002752_abnormal_somatic_nervous0.81280275
69MP0001485_abnormal_pinna_reflex0.81129454
70MP0001299_abnormal_eye_distance/0.80765151
71MP0001346_abnormal_lacrimal_gland0.79941515
72MP0005551_abnormal_eye_electrophysiolog0.79444605
73MP0003632_abnormal_nervous_system0.78026229
74MP0001177_atelectasis0.77967447
75MP0001986_abnormal_taste_sensitivity0.76345741
76MP0004085_abnormal_heartbeat0.75528909
77MP0008872_abnormal_physiological_respon0.74373868
78MP0005623_abnormal_meninges_morphology0.74030170
79MP0005394_taste/olfaction_phenotype0.70512809
80MP0005499_abnormal_olfactory_system0.70512809
81MP0003283_abnormal_digestive_organ0.69722610
82MP0008874_decreased_physiological_sensi0.69067132
83MP0003690_abnormal_glial_cell0.68294437
84MP0004233_abnormal_muscle_weight0.68000174
85MP0008961_abnormal_basal_metabolism0.67521336
86MP0002837_dystrophic_cardiac_calcinosis0.66886709
87MP0004147_increased_porphyrin_level0.66691408
88MP0003861_abnormal_nervous_system0.66082524
89MP0001664_abnormal_digestion0.65123266
90MP0001943_abnormal_respiration0.64362115
91MP0005171_absent_coat_pigmentation0.63529050
92MP0002653_abnormal_ependyma_morphology0.62741804
93MP0003137_abnormal_impulse_conducting0.62080981
94MP0005535_abnormal_body_temperature0.61742003
95MP0003075_altered_response_to0.60082794
96MP0000026_abnormal_inner_ear0.59872052
97MP0000604_amyloidosis0.59785303
98MP0000747_muscle_weakness0.59707462
99MP0000534_abnormal_ureter_morphology0.59481674
100MP0004215_abnormal_myocardial_fiber0.59284574
101MP0010768_mortality/aging0.57551865
102MP0002102_abnormal_ear_morphology0.56247281
103MP0008438_abnormal_cutaneous_collagen0.55468057
104MP0005167_abnormal_blood-brain_barrier0.55275410
105MP0003385_abnormal_body_wall0.55233309
106MP0000013_abnormal_adipose_tissue0.55091385
107MP0002876_abnormal_thyroid_physiology0.54089125
108MP0002751_abnormal_autonomic_nervous0.53298466
109MP0006292_abnormal_olfactory_placode0.53080504
110MP0000579_abnormal_nail_morphology0.52400270
111MP0010769_abnormal_survival0.52044066
112MP0002082_postnatal_lethality0.51911174
113MP0010770_preweaning_lethality0.51911174
114MP0001958_emphysema0.51233377
115MP0004130_abnormal_muscle_cell0.50725245
116MP0003121_genomic_imprinting0.50708410
117MP0002081_perinatal_lethality0.50616944
118MP0008877_abnormal_DNA_methylation0.49167964
119MP0003938_abnormal_ear_development0.48643037

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.24399048
2Myokymia (HP:0002411)5.96983943
3Focal seizures (HP:0007359)5.52212295
4Action tremor (HP:0002345)4.86905272
5Ulnar claw (HP:0001178)4.66316488
6Epileptic encephalopathy (HP:0200134)4.63038672
7Insidious onset (HP:0003587)4.36266546
8Termporal pattern (HP:0011008)4.36266546
9Febrile seizures (HP:0002373)4.21675178
10Atonic seizures (HP:0010819)4.13472536
11Visual hallucinations (HP:0002367)4.07538282
12Progressive cerebellar ataxia (HP:0002073)3.79450180
13Absence seizures (HP:0002121)3.67420323
14Generalized tonic-clonic seizures (HP:0002069)3.57930379
15Broad-based gait (HP:0002136)3.46667773
16Dialeptic seizures (HP:0011146)3.41448881
17Obstructive sleep apnea (HP:0002870)3.32615952
18Hyperventilation (HP:0002883)3.29111788
19Ankle clonus (HP:0011448)3.22935763
20Amblyopia (HP:0000646)3.19559544
21Supranuclear gaze palsy (HP:0000605)3.13897922
22Impaired vibration sensation in the lower limbs (HP:0002166)3.08306452
23Poor eye contact (HP:0000817)3.05191059
24Gaze-evoked nystagmus (HP:0000640)2.94185954
25Abnormal eating behavior (HP:0100738)2.81877966
26Segmental peripheral demyelination/remyelination (HP:0003481)2.81827665
27Fetal akinesia sequence (HP:0001989)2.80156168
28Truncal ataxia (HP:0002078)2.78293214
29Urinary bladder sphincter dysfunction (HP:0002839)2.77079174
30Hemiparesis (HP:0001269)2.71919415
31Drooling (HP:0002307)2.69599676
32Excessive salivation (HP:0003781)2.69599676
33Impaired social interactions (HP:0000735)2.67492700
34Abnormal social behavior (HP:0012433)2.67492700
35Dysdiadochokinesis (HP:0002075)2.63786839
36Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.63509306
37Craniofacial dystonia (HP:0012179)2.60729926
38Urinary urgency (HP:0000012)2.58713686
39Tetraplegia (HP:0002445)2.56665396
40Depression (HP:0000716)2.54851391
41Dysmetria (HP:0001310)2.52528993
42Insomnia (HP:0100785)2.46394868
43Steppage gait (HP:0003376)2.44387682
44Peripheral hypomyelination (HP:0007182)2.43060552
45Intention tremor (HP:0002080)2.40606191
46Limb dystonia (HP:0002451)2.39369540
47Lower limb amyotrophy (HP:0007210)2.36481478
48Polyphagia (HP:0002591)2.36352190
49Anxiety (HP:0000739)2.35342010
50Onion bulb formation (HP:0003383)2.34751982
51Hammertoe (HP:0001765)2.34737576
52Clonus (HP:0002169)2.31990748
53Stereotypic behavior (HP:0000733)2.31518486
54Diplopia (HP:0000651)2.30796060
55Abnormality of binocular vision (HP:0011514)2.30796060
56Sleep apnea (HP:0010535)2.30584359
57Epileptiform EEG discharges (HP:0011182)2.28988516
58Spastic gait (HP:0002064)2.26592493
59Failure to thrive in infancy (HP:0001531)2.26244736
60Postural tremor (HP:0002174)2.23653014
61Cerebral hypomyelination (HP:0006808)2.23139855
62Genetic anticipation (HP:0003743)2.21545373
63Mutism (HP:0002300)2.18970930
64Progressive inability to walk (HP:0002505)2.17385248
65Cerebral inclusion bodies (HP:0100314)2.16210694
66Abnormality of the lower motor neuron (HP:0002366)2.15416587
67Absent speech (HP:0001344)2.15355786
68Impaired smooth pursuit (HP:0007772)2.14898349
69EEG with generalized epileptiform discharges (HP:0011198)2.14218141
70Neurofibrillary tangles (HP:0002185)2.14029545
71Postural instability (HP:0002172)2.12529796
72Delusions (HP:0000746)2.11759928
73Impaired proprioception (HP:0010831)2.11323561
74Neuronal loss in central nervous system (HP:0002529)2.11121179
75Lower limb muscle weakness (HP:0007340)2.10516898
76Torticollis (HP:0000473)2.10447138
77Aplasia involving bones of the extremities (HP:0009825)2.08812578
78Aplasia involving bones of the upper limbs (HP:0009823)2.08812578
79Aplasia of the phalanges of the hand (HP:0009802)2.08812578
80Inability to walk (HP:0002540)2.07920593
81Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.07723687
82Hypoventilation (HP:0002791)2.06738424
83Spastic tetraparesis (HP:0001285)2.06575132
84Shallow orbits (HP:0000586)2.05664450
85Apathy (HP:0000741)2.05659341
86Megalencephaly (HP:0001355)2.02799301
87Scanning speech (HP:0002168)2.01851889
88Hypsarrhythmia (HP:0002521)2.00796600
89Impaired vibratory sensation (HP:0002495)1.98412022
90Protruding tongue (HP:0010808)1.98314671
91Pheochromocytoma (HP:0002666)1.97090661
92Hemiplegia (HP:0002301)1.95446172
93Gait ataxia (HP:0002066)1.94311487
94Morphological abnormality of the pyramidal tract (HP:0002062)1.93378608
95Mild short stature (HP:0003502)1.93268377
96Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.93071376
97Degeneration of the lateral corticospinal tracts (HP:0002314)1.93071376
98Focal dystonia (HP:0004373)1.92278307
99Abnormality of the corticospinal tract (HP:0002492)1.92078060
100Bundle branch block (HP:0011710)1.91195607
101Split foot (HP:0001839)1.91194885
102Abnormality of ocular smooth pursuit (HP:0000617)1.90041236
103Hypoplasia of the brainstem (HP:0002365)1.89972443
104Aplasia/Hypoplasia of the brainstem (HP:0007362)1.89972443
105Protrusio acetabuli (HP:0003179)1.89411936
106Exotropia (HP:0000577)1.89131407
107Bradykinesia (HP:0002067)1.88100983
108Status epilepticus (HP:0002133)1.88012446
109Amyotrophic lateral sclerosis (HP:0007354)1.86726887
110Papilledema (HP:0001085)1.86614585
111Decreased motor nerve conduction velocity (HP:0003431)1.85067922
112Hand muscle atrophy (HP:0009130)1.83140851
113Upper limb amyotrophy (HP:0009129)1.82728326
114Distal upper limb amyotrophy (HP:0007149)1.82728326
115Bronchomalacia (HP:0002780)1.82566954
116Akinesia (HP:0002304)1.82014871
117Pointed chin (HP:0000307)1.81419988
118Diminished motivation (HP:0000745)1.80678832
119Narrow nasal bridge (HP:0000446)1.80418894
120Abnormality of salivation (HP:0100755)1.79259726
121Incomplete penetrance (HP:0003829)1.76682033
122Progressive sensorineural hearing impairment (HP:0000408)1.75982919
123Spinal canal stenosis (HP:0003416)1.75714559
124Abnormality of the vocal cords (HP:0008777)1.75564431
125Blue irides (HP:0000635)1.74016672
126Foot dorsiflexor weakness (HP:0009027)1.74016082
127Annular pancreas (HP:0001734)1.72403578

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.48398512
2EPHA44.45944425
3MAP3K93.58202939
4MARK13.14705025
5MAP3K42.97122887
6CASK2.60095321
7MAP2K72.59655904
8MINK12.57839170
9DAPK22.53916450
10NTRK22.22223527
11RIPK42.12954371
12TNIK2.09456774
13PAK62.04167743
14MAP3K122.03037446
15KSR21.79010072
16MAP2K41.78952166
17MAPK131.73818675
18NTRK11.61236393
19KSR11.60538979
20PRKD31.57827407
21PRPF4B1.57238651
22CDK191.56203783
23CDK51.53373598
24DAPK11.51928297
25SIK21.51773592
26PLK21.42815966
27MUSK1.41844488
28CAMKK11.33678308
29UHMK11.29940401
30PNCK1.28521208
31GRK51.19716192
32PHKG21.10889681
33PHKG11.10889681
34TYRO31.10388821
35PRKCG1.08045839
36SIK31.07290788
37FES1.05416435
38SGK2231.00826890
39SGK4941.00826890
40RIPK11.00253741
41CAMK2A0.98164828
42MAP3K20.98017079
43CDK180.97959086
44STK380.96031739
45LIMK10.95610479
46CDK150.92695847
47LMTK20.89794176
48LATS20.89142342
49CDK140.88764016
50RET0.84868282
51ARAF0.83608220
52SGK20.82150093
53BMPR20.81493256
54CDK11A0.81297371
55CAMK2G0.78605625
56DYRK1A0.78590805
57CAMK2B0.77776145
58WNK30.76688248
59PTK2B0.76631181
60MAP3K130.74350005
61PDGFRA0.73521232
62OXSR10.72919532
63CAMKK20.71598923
64STK110.69868481
65ALK0.69734740
66PINK10.68474514
67CAMK10.68055077
68MARK20.67747604
69SGK10.66689326
70CCNB10.62052955
71PKN10.61190664
72SGK30.60275149
73CSNK1G20.60172811
74NME10.58762109
75FGR0.58347638
76BRAF0.55580297
77CDC42BPA0.55324801
78PRKCE0.54671921
79PAK30.54509343
80CAMK1G0.53436366
81BCR0.53209527
82DAPK30.49027717
83FER0.48701755
84MAP2K10.48371086
85FGFR20.48084703
86BRSK10.47453162
87PRKCH0.47208439
88NEK60.46309222
89RAF10.46216529
90TAOK10.45546627
91ICK0.45530799
92ROCK20.45170190
93RPS6KA30.44169396
94MAPK100.43326535
95PRKCZ0.41942778
96ADRBK10.41664087
97MAP3K10.41177626
98MAP3K110.40863022
99TNK20.40824025
100PDPK10.40550486
101FYN0.40356509
102MOS0.40137922
103MAPK120.39563053
104PTK20.39065599
105CAMK40.38914685
106PAK20.38737268
107WNK10.38164981
108PDK10.38046700
109TESK10.37641378
110DDR20.37584416
111RPS6KA20.36642950
112ROCK10.36429037
113CAMK2D0.36424293
114EPHB20.35884618
115DMPK0.35476110
116PRKCA0.31906828
117PRKD20.31384108
118CSNK1D0.29828822
119PRKG10.28608810

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.85094328
2Synaptic vesicle cycle_Homo sapiens_hsa047212.94682837
3Circadian entrainment_Homo sapiens_hsa047132.64218589
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.63824670
5Glutamatergic synapse_Homo sapiens_hsa047242.59002731
6Olfactory transduction_Homo sapiens_hsa047402.58353533
7Long-term potentiation_Homo sapiens_hsa047202.56810412
8GABAergic synapse_Homo sapiens_hsa047272.53781757
9Morphine addiction_Homo sapiens_hsa050322.42644702
10Amphetamine addiction_Homo sapiens_hsa050312.38787524
11Dopaminergic synapse_Homo sapiens_hsa047282.16083665
12Salivary secretion_Homo sapiens_hsa049702.11658394
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.00267830
14Insulin secretion_Homo sapiens_hsa049111.94060579
15Cholinergic synapse_Homo sapiens_hsa047251.86205573
16Taste transduction_Homo sapiens_hsa047421.82978075
17Gastric acid secretion_Homo sapiens_hsa049711.79018261
18Renin secretion_Homo sapiens_hsa049241.73049653
19Long-term depression_Homo sapiens_hsa047301.70823730
20Serotonergic synapse_Homo sapiens_hsa047261.70781975
21Oxytocin signaling pathway_Homo sapiens_hsa049211.70001634
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.67983167
23Cocaine addiction_Homo sapiens_hsa050301.66308040
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.66125975
25Calcium signaling pathway_Homo sapiens_hsa040201.65374633
26Axon guidance_Homo sapiens_hsa043601.49029691
27GnRH signaling pathway_Homo sapiens_hsa049121.46645896
28Gap junction_Homo sapiens_hsa045401.40276006
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.39013766
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.35450776
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.30864184
32Collecting duct acid secretion_Homo sapiens_hsa049661.30547185
33cAMP signaling pathway_Homo sapiens_hsa040241.23589583
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.23542344
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15800740
36Glioma_Homo sapiens_hsa052141.14786536
37Dorso-ventral axis formation_Homo sapiens_hsa043201.14765631
38ErbB signaling pathway_Homo sapiens_hsa040121.14565954
39Estrogen signaling pathway_Homo sapiens_hsa049151.11209829
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09799667
41Melanogenesis_Homo sapiens_hsa049161.07020009
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.06032720
43Type II diabetes mellitus_Homo sapiens_hsa049301.04732337
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04635427
45Cardiac muscle contraction_Homo sapiens_hsa042601.03170276
46Vitamin B6 metabolism_Homo sapiens_hsa007500.98939993
47Dilated cardiomyopathy_Homo sapiens_hsa054140.91744808
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.90730415
49Phototransduction_Homo sapiens_hsa047440.89379949
50Phospholipase D signaling pathway_Homo sapiens_hsa040720.86163532
51Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.83153306
52MAPK signaling pathway_Homo sapiens_hsa040100.82136488
53Oocyte meiosis_Homo sapiens_hsa041140.81165117
54Vibrio cholerae infection_Homo sapiens_hsa051100.80995854
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79587170
56Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79475101
57Pancreatic secretion_Homo sapiens_hsa049720.78115209
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77173850
59Choline metabolism in cancer_Homo sapiens_hsa052310.75819955
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75259797
61Ras signaling pathway_Homo sapiens_hsa040140.69632658
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69268603
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.68277482
64Thyroid hormone synthesis_Homo sapiens_hsa049180.66314596
65VEGF signaling pathway_Homo sapiens_hsa043700.66311373
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66150564
67Circadian rhythm_Homo sapiens_hsa047100.65168426
68Rap1 signaling pathway_Homo sapiens_hsa040150.65114096
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62761224
70Hippo signaling pathway_Homo sapiens_hsa043900.60852164
71Wnt signaling pathway_Homo sapiens_hsa043100.60398934
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60172574
73Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59462379
74African trypanosomiasis_Homo sapiens_hsa051430.56430433
75Glucagon signaling pathway_Homo sapiens_hsa049220.55404299
76Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54701786
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.54693735
78Alcoholism_Homo sapiens_hsa050340.54574917
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51869804
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51816967
81Endometrial cancer_Homo sapiens_hsa052130.49751777
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49467806
83mTOR signaling pathway_Homo sapiens_hsa041500.48423244
84Tight junction_Homo sapiens_hsa045300.46542317
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46068144
86Inositol phosphate metabolism_Homo sapiens_hsa005620.45760279
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45622532
88Prion diseases_Homo sapiens_hsa050200.45247270
89Focal adhesion_Homo sapiens_hsa045100.43841668
90Insulin signaling pathway_Homo sapiens_hsa049100.43747920
91Renal cell carcinoma_Homo sapiens_hsa052110.43272062
92ECM-receptor interaction_Homo sapiens_hsa045120.41872266
93Alzheimers disease_Homo sapiens_hsa050100.40841394
94Endocytosis_Homo sapiens_hsa041440.40566129
95Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.40274828
96Nitrogen metabolism_Homo sapiens_hsa009100.39893629
97Non-small cell lung cancer_Homo sapiens_hsa052230.38850233
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36731398
99Hedgehog signaling pathway_Homo sapiens_hsa043400.36199398
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35493189
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35088217
102Type I diabetes mellitus_Homo sapiens_hsa049400.34059913
103Colorectal cancer_Homo sapiens_hsa052100.32922741
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.31754433
105Chemokine signaling pathway_Homo sapiens_hsa040620.31598967
106Melanoma_Homo sapiens_hsa052180.31384713
107Ovarian steroidogenesis_Homo sapiens_hsa049130.31085759
108Protein digestion and absorption_Homo sapiens_hsa049740.30996815
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30457171
110AMPK signaling pathway_Homo sapiens_hsa041520.27999111
111Amoebiasis_Homo sapiens_hsa051460.27770528
112SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27749956
113Bile secretion_Homo sapiens_hsa049760.27629458

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