DRD4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of visible light (GO:0009584)9.96042203
2protein-chromophore linkage (GO:0018298)9.15360862
3visual perception (GO:0007601)8.76685710
4GMP metabolic process (GO:0046037)8.76343767
5sensory perception of light stimulus (GO:0050953)8.66109176
6retinal rod cell development (GO:0046548)7.78794920
7regulation of cGMP metabolic process (GO:0030823)7.74617002
8cellular response to light stimulus (GO:0071482)7.47218371
9positive regulation of cGMP biosynthetic process (GO:0030828)7.37834395
10photoreceptor cell differentiation (GO:0046530)7.21823098
11eye photoreceptor cell differentiation (GO:0001754)7.21823098
12detection of external stimulus (GO:0009581)6.99511274
13detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)6.98353758
14regulation of cGMP biosynthetic process (GO:0030826)6.92746496
15detection of abiotic stimulus (GO:0009582)6.85193237
16positive regulation of cGMP metabolic process (GO:0030825)6.56310773
17receptor guanylyl cyclase signaling pathway (GO:0007168)6.20003403
18* retina development in camera-type eye (GO:0060041)6.05900097
19specification of organ identity (GO:0010092)5.76454537
20mitochondrion distribution (GO:0048311)5.20238787
21hindbrain development (GO:0030902)5.16070822
22establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.98541348
23mitochondrion transport along microtubule (GO:0047497)4.98541348
24L-serine metabolic process (GO:0006563)4.89053181
25establishment of mitochondrion localization (GO:0051654)4.88884707
26cellular response to radiation (GO:0071478)4.84657374
27ribosomal small subunit biogenesis (GO:0042274)4.83447714
28cell morphogenesis involved in neuron differentiation (GO:0048667)4.78682756
29convergent extension (GO:0060026)4.38262754
30cell proliferation in forebrain (GO:0021846)4.35155377
31nonmotile primary cilium assembly (GO:0035058)4.34456112
32regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)4.31473229
33neuronal stem cell maintenance (GO:0097150)4.27804594
34pyrimidine nucleobase catabolic process (GO:0006208)4.21499761
35somite development (GO:0061053)4.17298089
36sensory perception (GO:0007600)4.14851374
37pyrimidine nucleotide catabolic process (GO:0006244)4.11919700
38pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.03909670
39detection of chemical stimulus involved in sensory perception of taste (GO:0050912)3.97662581
40mitochondrion localization (GO:0051646)3.94266466
41viral transcription (GO:0019083)3.93706560
42ribosomal small subunit assembly (GO:0000028)3.93608053
43regulation of posttranscriptional gene silencing (GO:0060147)3.93012576
44regulation of gene silencing by miRNA (GO:0060964)3.93012576
45regulation of gene silencing by RNA (GO:0060966)3.93012576
46substrate-independent telencephalic tangential migration (GO:0021826)3.79004832
47substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.79004832
48* response to light stimulus (GO:0009416)3.77282830
49adaptation of signaling pathway (GO:0023058)3.74420570
50regulation of clathrin-mediated endocytosis (GO:2000369)3.74129156
51translational termination (GO:0006415)3.72312396
52retina homeostasis (GO:0001895)3.64282300
53positive regulation of protein deacetylation (GO:0090312)3.61837716
54hypothalamus development (GO:0021854)3.60052178
55prenylation (GO:0097354)3.59306666
56protein prenylation (GO:0018342)3.59306666
57positive regulation of male gonad development (GO:2000020)3.58763879
58cell migration in hindbrain (GO:0021535)3.58105096
59detection of chemical stimulus involved in sensory perception (GO:0050907)3.57221183
60tachykinin receptor signaling pathway (GO:0007217)3.56119905
61limb development (GO:0060173)3.50173479
62appendage development (GO:0048736)3.50173479
63negative regulation of response to food (GO:0032096)3.49347796
64negative regulation of appetite (GO:0032099)3.49347796
65estrogen biosynthetic process (GO:0006703)3.48046443
66heterochromatin organization (GO:0070828)3.46478133
67positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)3.45030382
68neuron development (GO:0048666)3.43767210
69auditory receptor cell differentiation (GO:0042491)3.42617074
70response to gravity (GO:0009629)3.41077409
71positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)3.35592551
72* regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.35297619
73epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.34702846
74CDP-diacylglycerol biosynthetic process (GO:0016024)3.30453462
75planar cell polarity pathway involved in neural tube closure (GO:0090179)3.27982284
76cardiovascular system development (GO:0072358)3.26631060
77male sex determination (GO:0030238)3.26219586
78nucleobase catabolic process (GO:0046113)3.24494465
79positive regulation of ERBB signaling pathway (GO:1901186)3.21382842
80kinetochore assembly (GO:0051382)3.18511751
81negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.13036616
82peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.09642983
83base-excision repair, AP site formation (GO:0006285)3.08100677
84neuron fate determination (GO:0048664)3.06660630
85serine family amino acid catabolic process (GO:0009071)3.06559382
86mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.05368871
87mitochondrial respiratory chain complex I assembly (GO:0032981)3.05368871
88NADH dehydrogenase complex assembly (GO:0010257)3.05368871
89kinetochore organization (GO:0051383)3.02440814
90sex determination (GO:0007530)3.02339630
91CDP-diacylglycerol metabolic process (GO:0046341)3.01176999
92spinal cord development (GO:0021510)2.98640493
93regulation of male gonad development (GO:2000018)2.98209536
94digestive tract morphogenesis (GO:0048546)2.96953104
95regulation of protein deacetylation (GO:0090311)2.96524040
96neuron recognition (GO:0008038)2.94459393
97cotranslational protein targeting to membrane (GO:0006613)2.94232326
98spinal cord association neuron differentiation (GO:0021527)2.93530408
99postsynaptic membrane organization (GO:0001941)2.93024075
100retinoid metabolic process (GO:0001523)2.92231357
101glycerophospholipid catabolic process (GO:0046475)2.92006540
102regulation of feeding behavior (GO:0060259)2.91458193
103protein targeting to ER (GO:0045047)2.89872452
104behavioral response to nicotine (GO:0035095)2.89334174
105SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.88893906
106embryonic retina morphogenesis in camera-type eye (GO:0060059)2.88462233
107negative regulation of receptor-mediated endocytosis (GO:0048261)2.87493821
108translational elongation (GO:0006414)2.84597791
109protein localization to synapse (GO:0035418)2.83578235
110nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.82839260
111negative regulation of DNA-templated transcription, elongation (GO:0032785)2.82399779
112retina layer formation (GO:0010842)2.81455999
113cellular protein complex disassembly (GO:0043624)2.79831348
114regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.79146873
115establishment of protein localization to endoplasmic reticulum (GO:0072599)2.78965860
116positive regulation of cyclase activity (GO:0031281)2.75907839
117positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.75417684
118serine family amino acid biosynthetic process (GO:0009070)2.74318136
119viral life cycle (GO:0019058)2.72303981
120nephron tubule morphogenesis (GO:0072078)2.72145534
121nephron epithelium morphogenesis (GO:0072088)2.72145534
122response to misfolded protein (GO:0051788)2.72062299
123axonal fasciculation (GO:0007413)2.72032015
124neuronal action potential propagation (GO:0019227)2.71920766
125head development (GO:0060322)2.71783429
126axon ensheathment in central nervous system (GO:0032291)2.71031195
127central nervous system myelination (GO:0022010)2.71031195
128body morphogenesis (GO:0010171)2.70507038
129negative regulation of JUN kinase activity (GO:0043508)2.70060341
130phospholipid translocation (GO:0045332)2.69330359
131lipid translocation (GO:0034204)2.69330359
132protein localization to endoplasmic reticulum (GO:0070972)2.69235526
133diterpenoid metabolic process (GO:0016101)2.68122099
134* short-term memory (GO:0007614)2.67807103
135neural tube development (GO:0021915)2.67450527
136tongue development (GO:0043586)2.65803210
137Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.65667291
138regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.64926532
139inner ear receptor cell differentiation (GO:0060113)2.64287647
140neuron projection extension involved in neuron projection guidance (GO:1902284)2.63721885
141axon extension involved in axon guidance (GO:0048846)2.63721885
142macroautophagy (GO:0016236)2.63417034
143* response to radiation (GO:0009314)2.63230128
144protein complex disassembly (GO:0043241)2.63151979
145regulation of short-term neuronal synaptic plasticity (GO:0048172)2.61961605
146microtubule bundle formation (GO:0001578)2.60831595
147RNA destabilization (GO:0050779)2.60707057
148negative regulation of astrocyte differentiation (GO:0048712)2.59969045
149positive regulation of RNA splicing (GO:0033120)2.58780763
150regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.57341304
151retinol metabolic process (GO:0042572)2.57089441
152negative regulation of transcription regulatory region DNA binding (GO:2000678)2.55720368
153protein heterotetramerization (GO:0051290)2.53668550
154positive regulation of lyase activity (GO:0051349)2.49466674
155cellular response to abiotic stimulus (GO:0071214)2.46394976
156terpenoid metabolic process (GO:0006721)2.43026255
157fatty acid elongation (GO:0030497)2.39008194
158axoneme assembly (GO:0035082)2.35409779
159gonadal mesoderm development (GO:0007506)2.34912921
160synaptic vesicle maturation (GO:0016188)2.32786945
161cellular response to leptin stimulus (GO:0044320)2.25440349
162response to leptin (GO:0044321)2.20966181
163synaptic vesicle docking involved in exocytosis (GO:0016081)2.17223446
164sensory perception of smell (GO:0007608)2.15907609
165regulation of meiosis I (GO:0060631)2.13348721
166post-embryonic morphogenesis (GO:0009886)2.10562923
167cellular potassium ion homeostasis (GO:0030007)2.09159234
168sensory perception of chemical stimulus (GO:0007606)2.05108097
169long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.04266279
170sensory perception of taste (GO:0050909)2.04155129
171negative regulation of macrophage differentiation (GO:0045650)2.01948353
172regulation of rhodopsin mediated signaling pathway (GO:0022400)18.3766430
173rhodopsin mediated signaling pathway (GO:0016056)17.7507749
174retinal cone cell development (GO:0046549)16.9795046
175photoreceptor cell development (GO:0042461)11.8717226
176positive regulation of guanylate cyclase activity (GO:0031284)11.8606420
177eye photoreceptor cell development (GO:0042462)11.5412169
178photoreceptor cell maintenance (GO:0045494)11.2779343
179detection of light stimulus involved in sensory perception (GO:0050962)11.1548546
180detection of light stimulus involved in visual perception (GO:0050908)11.1548546
181regulation of guanylate cyclase activity (GO:0031282)10.7153583
182phototransduction (GO:0007602)10.5679049
183phototransduction, visible light (GO:0007603)10.4175178
184detection of light stimulus (GO:0009583)10.0108547
185cellular response to electrical stimulus (GO:0071257)1.99256766
186lipoprotein transport (GO:0042953)1.98401440
187sodium ion export (GO:0071436)1.97448619
188cytokinetic process (GO:0032506)1.97292203
189melanosome transport (GO:0032402)1.96839321
190establishment of melanosome localization (GO:0032401)1.94291150
191righting reflex (GO:0060013)1.93622645
192negative regulation of peptidyl-threonine phosphorylation (GO:0010801)1.93254206
193isoprenoid metabolic process (GO:0006720)1.89321852
194fatty-acyl-CoA biosynthetic process (GO:0046949)1.88459309

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.02947184
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.76312461
3EZH2_22144423_ChIP-Seq_EOC_Human3.77327028
4CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse3.73322731
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.68849708
6VDR_22108803_ChIP-Seq_LS180_Human3.21800814
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.97058548
8DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.91587168
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.70416241
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.60550864
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.41601138
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.32411440
13* EZH2_27304074_Chip-Seq_ESCs_Mouse2.19299649
14TP53_20018659_ChIP-ChIP_R1E_Mouse2.12696814
15CBX2_27304074_Chip-Seq_ESCs_Mouse2.00498595
16CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.95879908
17PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.94643009
18CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.94531889
19KDM2B_26808549_Chip-Seq_K562_Human1.92834694
20DROSHA_22980978_ChIP-Seq_HELA_Human1.86951654
21CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.86590685
22CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.81923222
23BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.80099885
24EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76763693
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.74849697
26IKZF1_21737484_ChIP-ChIP_HCT116_Human1.74650540
27RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.74506990
28SRY_22984422_ChIP-ChIP_TESTIS_Rat1.72636549
29AR_21572438_ChIP-Seq_LNCaP_Human1.69916920
30ZNF263_19887448_ChIP-Seq_K562_Human1.68279252
31* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.67524562
32* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.61077808
33CREB1_26743006_Chip-Seq_LNCaP_Human1.59631540
34IRF1_19129219_ChIP-ChIP_H3396_Human1.59481702
35SMC4_20622854_ChIP-Seq_HELA_Human1.58635876
36SMAD3_21741376_ChIP-Seq_HESCs_Human1.58484091
37* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.53483015
38* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.52411304
39* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.51065930
40ZFP281_18757296_ChIP-ChIP_E14_Mouse1.48769142
41SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.47555902
42* EZH2_27294783_Chip-Seq_ESCs_Mouse1.44936708
43RING1B_27294783_Chip-Seq_NPCs_Mouse1.42972068
44TCF4_18268006_ChIP-ChIP_LS174T_Human1.42175484
45FOXP1_21924763_ChIP-Seq_HESCs_Human1.36698929
46CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.36627804
47ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.36011283
48CTCF_27219007_Chip-Seq_Bcells_Human1.34327367
49* XRN2_22483619_ChIP-Seq_HELA_Human1.33627264
50MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.33329308
51NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.32698041
52SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.32693539
53OCT4_19829295_ChIP-Seq_ESCs_Human1.32515251
54SA1_27219007_Chip-Seq_ERYTHROID_Human1.32440398
55EP300_21415370_ChIP-Seq_HL-1_Mouse1.31705458
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30589547
57EZH2_18974828_ChIP-Seq_MESCs_Mouse1.30507351
58RNF2_18974828_ChIP-Seq_MESCs_Mouse1.30507351
59GBX2_23144817_ChIP-Seq_PC3_Human1.27132001
60KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.24670263
61GATA1_26923725_Chip-Seq_HPCs_Mouse1.24453437
62TET1_21451524_ChIP-Seq_MESCs_Mouse1.24352283
63* AR_19668381_ChIP-Seq_PC3_Human1.23302094
64MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.21612198
65PHF8_20622854_ChIP-Seq_HELA_Human1.20805740
66ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.20610670
67* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.20533805
68* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20177566
69HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.19912947
70WDR5_24793694_ChIP-Seq_LNCAP_Human1.19528141
71RARB_27405468_Chip-Seq_BRAIN_Mouse1.18369920
72HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.17519673
73TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16920070
74HIF1A_21447827_ChIP-Seq_MCF-7_Human1.16573671
75* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.16189109
76* RNF2_27304074_Chip-Seq_ESCs_Mouse1.15875255
77REST_18959480_ChIP-ChIP_MESCs_Mouse1.15513647
78* RING1B_27294783_Chip-Seq_ESCs_Mouse1.15378237
79CTCF_20526341_ChIP-Seq_ESCs_Human1.14382938
80RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12931143
81UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.12711321
82TP53_22127205_ChIP-Seq_IMR90_Human1.11378091
83BCAT_22108803_ChIP-Seq_LS180_Human1.10482428
84BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10264543
85P68_20966046_ChIP-Seq_HELA_Human1.10097967
86SOX3_22085726_ChIP-Seq_NPCs_Mouse1.10067954
87* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.09373645
88THAP11_20581084_ChIP-Seq_MESCs_Mouse1.08883622
89CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08535120
90ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08066218
91SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.08000897
92* ERA_21632823_ChIP-Seq_H3396_Human1.07847284
93* LXR_22292898_ChIP-Seq_THP-1_Human1.06918123
94TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06155565
95ETS1_20019798_ChIP-Seq_JURKAT_Human1.06102785
96ISL1_27105846_Chip-Seq_CPCs_Mouse1.05754137
97SOX2_18555785_ChIP-Seq_MESCs_Mouse1.04073875
98NFIB_24661679_ChIP-Seq_LUNG_Mouse1.03784237
99* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.01310384
100NCOR_22424771_ChIP-Seq_293T_Human1.01150203
101RARA_24833708_ChIP-Seq_LIVER_Mouse1.00875369
102* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00424652
103KDM2B_26808549_Chip-Seq_JURKAT_Human0.98975445
104RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98889684
105ZFP281_27345836_Chip-Seq_ESCs_Mouse0.98742638
106CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98178337
107SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97833166
108POU3F2_20337985_ChIP-ChIP_501MEL_Human0.97510136
109ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.97283180
110* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.97121160
111CTCF_18555785_ChIP-Seq_MESCs_Mouse0.96857910
112* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.95933851
113* BCL6_27268052_Chip-Seq_Bcells_Human0.95924635
114JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.95674453
115AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95558834
116REST_21632747_ChIP-Seq_MESCs_Mouse0.95505938
117ZNF274_21170338_ChIP-Seq_K562_Hela0.95378457
118TBL1_22424771_ChIP-Seq_293T_Human0.94987079
119GABP_19822575_ChIP-Seq_HepG2_Human0.94942179
120PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.94487047
121EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.93703358
122ELK4_26923725_Chip-Seq_MESODERM_Mouse0.93044776
123TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92532185
124SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.92515790
125MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92240889
126GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.92005179
127SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91893279
128VDR_21846776_ChIP-Seq_THP-1_Human0.91878882
129DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.91589575
130TAF2_19829295_ChIP-Seq_ESCs_Human0.90663943
131MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90450629
132E2F1_17053090_ChIP-ChIP_MCF-7_Human0.90356779
133FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.89996897
134GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.89082761
135* JARID2_20064375_ChIP-Seq_MESCs_Mouse0.88956638
136GATA1_19941827_ChIP-Seq_MEL_Mouse0.88583239
137FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.88408679
138YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87394586
139P53_22127205_ChIP-Seq_FIBROBLAST_Human0.87324025
140* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.87308023
141ERG_20517297_ChIP-Seq_VCAP_Human0.86923308
142DNAJC2_21179169_ChIP-ChIP_NT2_Human0.86593074
143PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.86241632
144DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.86009225
145TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.85717749
146TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85631885
147EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.85095173
148KDM2B_26808549_Chip-Seq_DND41_Human0.84614752
149CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.84556938
150TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.83189395
151PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.83151592
152BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.81987751
153TP63_22573176_ChIP-Seq_HFKS_Human0.81458959
154CHD1_26751641_Chip-Seq_LNCaP_Human0.80928829
155SMAD4_21741376_ChIP-Seq_HESCs_Human0.80473583
156* SA1_27219007_Chip-Seq_Bcells_Human0.80330464
157YY1_22570637_ChIP-Seq_MALME-3M_Human0.79942629
158* ERG_21242973_ChIP-ChIP_JURKAT_Human0.79819831
159GF1_26923725_Chip-Seq_HPCs_Mouse0.79772261
160KDM2B_26808549_Chip-Seq_SUP-B15_Human0.79399693
161IGF1R_20145208_ChIP-Seq_DFB_Human0.79347294

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog9.77245569
2MP0005253_abnormal_eye_physiology6.94534679
3MP0006072_abnormal_retinal_apoptosis6.29234297
4MP0006292_abnormal_olfactory_placode5.46872063
5MP0003950_abnormal_plasma_membrane4.13832446
6MP0000566_synostosis4.12625896
7MP0009379_abnormal_foot_pigmentation4.04765426
8MP0005195_abnormal_posterior_eye3.69262187
9MP0010030_abnormal_orbit_morphology3.65123367
10MP0001293_anophthalmia3.32948612
11MP0005391_vision/eye_phenotype3.31781626
12MP0001324_abnormal_eye_pigmentation3.03511435
13MP0002090_abnormal_vision2.88656130
14MP0001986_abnormal_taste_sensitivity2.75150936
15MP0005423_abnormal_somatic_nervous2.71981287
16MP0002229_neurodegeneration2.44057455
17MP0003136_yellow_coat_color2.40255015
18MP0002638_abnormal_pupillary_reflex2.36062020
19MP0003122_maternal_imprinting2.22732353
20MP0005670_abnormal_white_adipose2.16170187
21MP0002938_white_spotting2.13453216
22MP0002233_abnormal_nose_morphology2.07950372
23MP0000778_abnormal_nervous_system2.07775372
24MP0003011_delayed_dark_adaptation10.6688816
25MP0001348_abnormal_lacrimal_gland1.91660886
26MP0003123_paternal_imprinting1.89876950
27MP0002752_abnormal_somatic_nervous1.81769402
28MP0001764_abnormal_homeostasis1.77844695
29MP0004133_heterotaxia1.77068413
30MP0002092_abnormal_eye_morphology1.63056963
31MP0003755_abnormal_palate_morphology1.61951882
32MP0002249_abnormal_larynx_morphology1.60321905
33MP0002736_abnormal_nociception_after1.52879548
34MP0000049_abnormal_middle_ear1.52471459
35MP0004019_abnormal_vitamin_homeostasis1.50337475
36MP0003938_abnormal_ear_development1.49847022
37MP0001968_abnormal_touch/_nociception1.35968386
38MP0003937_abnormal_limbs/digits/tail_de1.35286457
39MP0003880_abnormal_central_pattern1.34501786
40MP0003861_abnormal_nervous_system1.28089957
41MP0002735_abnormal_chemical_nociception1.25926408
42MP0003787_abnormal_imprinting1.25825681
43MP0001299_abnormal_eye_distance/1.25776661
44MP0002882_abnormal_neuron_morphology1.25263610
45MP0000955_abnormal_spinal_cord1.25004490
46MP0003121_genomic_imprinting1.24161200
47MP0004233_abnormal_muscle_weight1.22671205
48MP0002653_abnormal_ependyma_morphology1.17799318
49MP0001485_abnormal_pinna_reflex1.16995730
50MP0008995_early_reproductive_senescence1.15381047
51MP0001881_abnormal_mammary_gland1.14267885
52MP0000428_abnormal_craniofacial_morphol1.13205131
53MP0008877_abnormal_DNA_methylation1.13137781
54MP0003045_fibrosis1.08890069
55MP0002116_abnormal_craniofacial_bone1.08410471
56MP0004142_abnormal_muscle_tone1.07368727
57MP0001661_extended_life_span1.05700893
58MP0003942_abnormal_urinary_system1.04740150
59MP0000579_abnormal_nail_morphology1.04349978
60MP0003879_abnormal_hair_cell1.03317186
61MP0003119_abnormal_digestive_system1.02329761
62MP0001970_abnormal_pain_threshold1.00820582
63MP0002557_abnormal_social/conspecific_i1.00561337
64MP0003890_abnormal_embryonic-extraembry0.98255774
65MP0005197_abnormal_uvea_morphology0.97326000
66MP0001984_abnormal_olfaction0.96203071
67MP0002111_abnormal_tail_morphology0.94293676
68MP0002184_abnormal_innervation0.93442056
69MP0002332_abnormal_exercise_endurance0.93233277
70MP0009053_abnormal_anal_canal0.92731557
71MP0004885_abnormal_endolymph0.92469994
72MP0002733_abnormal_thermal_nociception0.91500798
73MP0000372_irregular_coat_pigmentation0.91167111
74MP0002234_abnormal_pharynx_morphology0.89266948
75MP0006276_abnormal_autonomic_nervous0.87790039
76MP0002932_abnormal_joint_morphology0.87481857
77MP0005174_abnormal_tail_pigmentation0.87429111
78MP0001346_abnormal_lacrimal_gland0.85538729
79MP0001529_abnormal_vocalization0.84330120
80MP0005248_abnormal_Harderian_gland0.84093458
81MP0002127_abnormal_cardiovascular_syste0.83419012
82MP0003646_muscle_fatigue0.81059941
83MP0001542_abnormal_bone_strength0.80962510
84MP0005187_abnormal_penis_morphology0.80067680
85MP0008775_abnormal_heart_ventricle0.76637336
86MP0008961_abnormal_basal_metabolism0.74013497
87* MP0009745_abnormal_behavioral_response0.73228559
88MP0005076_abnormal_cell_differentiation0.73079883
89MP0005377_hearing/vestibular/ear_phenot0.69790100
90MP0003878_abnormal_ear_physiology0.69790100
91MP0003634_abnormal_glial_cell0.67337321
92MP0000462_abnormal_digestive_system0.65814885
93MP0002069_abnormal_eating/drinking_beha0.65630251
94MP0000751_myopathy0.65313113
95MP0002109_abnormal_limb_morphology0.64249444
96MP0002089_abnormal_postnatal_growth/wei0.64129394
97MP0000432_abnormal_head_morphology0.62790344
98MP0001486_abnormal_startle_reflex0.59703972
99MP0004742_abnormal_vestibular_system0.58068502
100MP0002168_other_aberrant_phenotype0.57261769
101MP0001502_abnormal_circadian_rhythm0.56471040
102MP0001727_abnormal_embryo_implantation0.55071177
103MP0005499_abnormal_olfactory_system0.51712276
104MP0005394_taste/olfaction_phenotype0.51712276
105MP0004145_abnormal_muscle_electrophysio0.49840680
106MP0001963_abnormal_hearing_physiology0.49088262
107MP0005595_abnormal_vascular_smooth0.49054523
108MP0004270_analgesia0.48613999
109MP0001286_abnormal_eye_development0.48279000
110MP0002102_abnormal_ear_morphology0.48068553
111MP0003698_abnormal_male_reproductive0.46749851
112MP0005410_abnormal_fertilization0.44587852
113MP0000631_abnormal_neuroendocrine_gland0.42151941
114MP0008789_abnormal_olfactory_epithelium0.41696292
115MP0005376_homeostasis/metabolism_phenot0.41348757
116MP0002697_abnormal_eye_size0.40624265
117MP0009780_abnormal_chondrocyte_physiolo0.40029507
118* MP0002272_abnormal_nervous_system0.39792114
119MP0005193_abnormal_anterior_eye0.36732202
120MP0003936_abnormal_reproductive_system0.36483484
121MP0004043_abnormal_pH_regulation0.36299350
122MP0002108_abnormal_muscle_morphology0.35382847
123MP0005620_abnormal_muscle_contractility0.34630516
124MP0001929_abnormal_gametogenesis0.32843838
125MP0003195_calcinosis0.31786180
126MP0008004_abnormal_stomach_pH0.31185995
127MP0004147_increased_porphyrin_level0.30943381
128MP0009384_cardiac_valve_regurgitation0.30814394
129MP0002210_abnormal_sex_determination0.30356071
130MP0001145_abnormal_male_reproductive0.28861124
131MP0000465_gastrointestinal_hemorrhage0.28304350
132MP0004085_abnormal_heartbeat0.28255829
133MP0000627_abnormal_mammary_gland0.27152703
134MP0004036_abnormal_muscle_relaxation0.27122022
135MP0002734_abnormal_mechanical_nocicepti0.25439416
136MP0005395_other_phenotype0.25187063
137MP0000026_abnormal_inner_ear0.25057945
138MP0004215_abnormal_myocardial_fiber0.23988179
139MP0000653_abnormal_sex_gland0.23973754
140MP0004084_abnormal_cardiac_muscle0.23056814
141MP0002067_abnormal_sensory_capabilities0.22999280
142MP0000230_abnormal_systemic_arterial0.22772554
143MP0000639_abnormal_adrenal_gland0.22281958
144MP0003635_abnormal_synaptic_transmissio0.22212202
145MP0002064_seizures0.21938752
146MP0002161_abnormal_fertility/fecundity0.20485846
147MP0004859_abnormal_synaptic_plasticity0.18759820
148MP0003638_abnormal_response/metabolism_0.18348054
149* MP0002572_abnormal_emotion/affect_behav0.18176599
150MP0005386_behavior/neurological_phenoty0.17571945
151MP0004924_abnormal_behavior0.17571945
152MP0005647_abnormal_sex_gland0.15730539
153MP0002909_abnormal_adrenal_gland0.14963363
154MP0009046_muscle_twitch0.14653680
155MP0001440_abnormal_grooming_behavior0.14330298
156MP0004782_abnormal_surfactant_physiolog0.14278408
157MP0000750_abnormal_muscle_regeneration0.13967680
158MP0000767_abnormal_smooth_muscle0.13814474
159MP0002152_abnormal_brain_morphology0.13166319
160* MP0002063_abnormal_learning/memory/cond0.12853529

Predicted human phenotypes

RankGene SetZ-score
1Abnormal rod and cone electroretinograms (HP:0008323)9.94084458
2Dyschromatopsia (HP:0007641)9.46248742
3Pigmentary retinal degeneration (HP:0001146)9.44311321
4Attenuation of retinal blood vessels (HP:0007843)7.78042806
5Chorioretinal atrophy (HP:0000533)7.74062948
6Abnormality of macular pigmentation (HP:0008002)7.64102703
7Central scotoma (HP:0000603)7.55448790
8Pendular nystagmus (HP:0012043)7.34650494
9Scotoma (HP:0000575)6.86059577
10Decreased central vision (HP:0007663)6.41410044
11Rib fusion (HP:0000902)6.27258918
12Abolished electroretinogram (ERG) (HP:0000550)6.00705635
13Vitreoretinal degeneration (HP:0000655)5.91602869
14Photophobia (HP:0000613)5.73219560
15Type II diabetes mellitus (HP:0005978)5.60830878
16Macular degeneration (HP:0000608)5.06267463
17Reticulocytopenia (HP:0001896)4.69080435
18Keratoconus (HP:0000563)4.56890734
19Increased corneal curvature (HP:0100692)4.56890734
20Retinitis pigmentosa (HP:0000510)4.49616052
21Choroideremia (HP:0001139)4.37302587
22Cone-rod dystrophy (HP:0000548)4.33986606
23Severe visual impairment (HP:0001141)4.20578065
24Posterior subcapsular cataract (HP:0007787)4.06206556
25Septo-optic dysplasia (HP:0100842)3.70312429
26Decreased electroretinogram (ERG) amplitude (HP:0000654)3.62310718
27Constricted visual fields (HP:0001133)3.60401108
28Renal dysplasia (HP:0000110)3.14989611
29Myokymia (HP:0002411)3.07670964
30Absent septum pellucidum (HP:0001331)2.89385958
31Thoracic kyphosis (HP:0002942)2.85270626
32Abnormal number of incisors (HP:0011064)2.84627340
33Abnormality of cells of the erythroid lineage (HP:0012130)2.78210252
34Partial duplication of thumb phalanx (HP:0009944)2.76478729
35Progressive visual loss (HP:0000529)2.72509880
36Anophthalmia (HP:0000528)2.71007159
37Shawl scrotum (HP:0000049)2.66141007
38Retinal atrophy (HP:0001105)2.64873025
39Optic disc pallor (HP:0000543)2.63486176
40Subcapsular cataract (HP:0000523)2.59761341
41Macrocytic anemia (HP:0001972)2.57513754
42Supernumerary ribs (HP:0005815)2.53746553
43Supernumerary bones of the axial skeleton (HP:0009144)2.52996159
44Facial hemangioma (HP:0000329)2.52799980
45Turricephaly (HP:0000262)2.51801708
46Absent thumb (HP:0009777)2.50732584
47Wide nasal bridge (HP:0000431)2.50674176
48Lissencephaly (HP:0001339)2.48921818
49Congenital sensorineural hearing impairment (HP:0008527)2.40753571
50Hypoplastic pelvis (HP:0008839)2.36970336
51Congenital primary aphakia (HP:0007707)2.36697443
52Fetal akinesia sequence (HP:0001989)2.36312046
53Partial duplication of the phalanx of hand (HP:0009999)2.32837062
5411 pairs of ribs (HP:0000878)2.28820753
55Occipital encephalocele (HP:0002085)2.28554867
56Gait imbalance (HP:0002141)2.28070876
57Tented upper lip vermilion (HP:0010804)2.27647842
58High anterior hairline (HP:0009890)2.27389991
59Abnormality of the diencephalon (HP:0010662)2.27338653
60Duplication of thumb phalanx (HP:0009942)2.23846937
61Oligodactyly (HP:0012165)2.22798785
62Abnormality of the septum pellucidum (HP:0007375)2.19635068
63Submucous cleft hard palate (HP:0000176)2.15826900
64Abnormal number of erythroid precursors (HP:0012131)2.15640203
65Ectopic kidney (HP:0000086)2.14569899
66Broad phalanges of the hand (HP:0009768)2.10242772
67Abnormality of DNA repair (HP:0003254)2.09514149
68Aplasia/Hypoplasia of the sacrum (HP:0008517)2.09344428
69Chromsome breakage (HP:0040012)2.04706239
70Anencephaly (HP:0002323)2.03377391
71Nephronophthisis (HP:0000090)2.02535134
72Broad finger (HP:0001500)2.01275841
73Congenital stationary night blindness (HP:0007642)16.1296971
74Bony spicule pigmentary retinopathy (HP:0007737)11.5271666
75Absent rod-and cone-mediated responses on ERG (HP:0007688)10.3614578
76Irregular epiphyses (HP:0010582)1.99916760
77Patent foramen ovale (HP:0001655)1.99009426
78Abnormality of cochlea (HP:0000375)1.97746638
79Birth length less than 3rd percentile (HP:0003561)1.97306198
80Pallor (HP:0000980)1.97267986
81Esotropia (HP:0000565)1.97100233
82Hemivertebrae (HP:0002937)1.96039675
83Bifid tongue (HP:0010297)1.95803142
84Nephrogenic diabetes insipidus (HP:0009806)1.94251560
85Broad thumb (HP:0011304)1.94089957
86Medial flaring of the eyebrow (HP:0010747)1.93207559
87Optic nerve hypoplasia (HP:0000609)1.91038406
88Triphalangeal thumb (HP:0001199)1.90263148
89Missing ribs (HP:0000921)1.90087427
90Chromosomal breakage induced by crosslinking agents (HP:0003221)1.88413913
91Acute necrotizing encephalopathy (HP:0006965)1.87368687
92Aplasia/Hypoplasia of the brainstem (HP:0007362)1.85929257
93Hypoplasia of the brainstem (HP:0002365)1.85929257
94Hypoplasia of the radius (HP:0002984)1.85284058
95Broad distal phalanx of finger (HP:0009836)1.84992122
96Pancreatic cysts (HP:0001737)1.83832994
97Chronic hepatic failure (HP:0100626)1.82950874
98Broad phalanx (HP:0006009)1.82908706
99Retinal dysplasia (HP:0007973)1.81507402
100Squamous cell carcinoma (HP:0002860)1.81457027
101Postaxial hand polydactyly (HP:0001162)1.81442532
102Aganglionic megacolon (HP:0002251)1.81367359
103Tracheomalacia (HP:0002779)1.81119124
104Anterior segment dysgenesis (HP:0007700)1.81091092
105Limb dystonia (HP:0002451)1.81065000
106Abnormality of the aortic arch (HP:0012303)1.79337497
107Pointed chin (HP:0000307)1.79267269
108Pachygyria (HP:0001302)1.78926699
109Optic nerve coloboma (HP:0000588)1.77653959
110Adrenal hypoplasia (HP:0000835)1.76832687
111Abnormality of the thoracic spine (HP:0100711)1.75871623
112Intellectual disability, moderate (HP:0002342)1.74395427
113Vertebral arch anomaly (HP:0008438)1.73774938
114Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.72889075
115Severe muscular hypotonia (HP:0006829)1.71962397
116Narrow forehead (HP:0000341)1.70949254
117Spastic tetraplegia (HP:0002510)1.70858754
118Poor coordination (HP:0002370)1.69561018
119Preaxial hand polydactyly (HP:0001177)1.69403378
120Hypsarrhythmia (HP:0002521)1.68336341
121Stenosis of the external auditory canal (HP:0000402)1.67084423
122True hermaphroditism (HP:0010459)1.65184940
123Abnormal sex determination (HP:0012244)1.57902735
124Sex reversal (HP:0012245)1.57902735
125Optic atrophy (HP:0000648)1.54295261
126Polar cataract (HP:0010696)1.54283043
127Vaginal atresia (HP:0000148)1.53924147
128Severe Myopia (HP:0011003)1.52457988
129Genital tract atresia (HP:0001827)1.47339236
130Gonadal dysgenesis (HP:0000133)1.41466472
131Horizontal nystagmus (HP:0000666)1.36367301
132Interstitial pulmonary disease (HP:0006530)1.35660683
133Aplasia/Hypoplasia of the lens (HP:0008063)1.34262535
134Dysdiadochokinesis (HP:0002075)1.28044921
135Male pseudohermaphroditism (HP:0000037)1.22173894
136Retinal detachment (HP:0000541)1.15258837
137Hand muscle atrophy (HP:0009130)1.13093590
138Epileptic encephalopathy (HP:0200134)1.10174590
139Zonular cataract (HP:0010920)1.09639947
140Cerebellar dysplasia (HP:0007033)1.08099322
141Astigmatism (HP:0000483)1.05168665
142Male infertility (HP:0003251)1.00123747
143Broad foot (HP:0001769)1.00121932
144Metaphyseal cupping (HP:0003021)0.99889509
145Abnormality of dental color (HP:0011073)0.99397134
146Polycystic ovaries (HP:0000147)0.98997435
147Decreased testicular size (HP:0008734)0.97151124
148Hypoventilation (HP:0002791)0.96501463
149Specific learning disability (HP:0001328)0.95772572
150Pancreatic fibrosis (HP:0100732)0.94542810
151Nuclear cataract (HP:0100018)0.94242124
152Chorioretinal coloboma (HP:0000567)0.94225374
153Testicular neoplasm (HP:0010788)0.94020189
154Hypermetropia (HP:0000540)0.87098374
155Left ventricular hypertrophy (HP:0001712)0.85173849
156Upper limb amyotrophy (HP:0009129)0.84399351
157Distal upper limb amyotrophy (HP:0007149)0.84399351
158Cystic liver disease (HP:0006706)0.83844758
159Clumsiness (HP:0002312)0.83683928
160Heterotopia (HP:0002282)0.82672065
161Ankle clonus (HP:0011448)0.81655409
162Truncal ataxia (HP:0002078)0.80009474
163Recurrent sinusitis (HP:0011108)0.78168578
164Abnormality of the fovea (HP:0000493)0.77126498
165Aplasia/Hypoplasia of the macula (HP:0008059)0.77073551
166Asthma (HP:0002099)0.77019387
167Progressive cerebellar ataxia (HP:0002073)0.76851106
168Aplasia/Hypoplasia affecting the retina (HP:0008061)0.72316830
169Epiphyseal dysplasia (HP:0002656)0.71277968
170Amelogenesis imperfecta (HP:0000705)0.70162076
171Sclerocornea (HP:0000647)0.69527192
172Partial agenesis of the corpus callosum (HP:0001338)0.69432547
173Aplasia/Hypoplasia of the tongue (HP:0010295)0.68455890
174Corneal dystrophy (HP:0001131)0.67793235
175Gonadotropin excess (HP:0000837)0.66996828
176Dysmetric saccades (HP:0000641)0.66284057
177Hypoplasia of the fovea (HP:0007750)0.65369614
178Aplasia/Hypoplasia of the fovea (HP:0008060)0.65369614
179Vertebral clefting (HP:0008428)0.65111584
180Abnormality of midbrain morphology (HP:0002418)0.64688400
181Molar tooth sign on MRI (HP:0002419)0.64688400
182Long foot (HP:0001833)0.63969072
183Dental crowding (HP:0000678)0.63781148

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK18.27082869
2PRPF4B6.53575879
3PBK6.45913489
4CAMK1D5.75307689
5CAMK1G4.88651349
6TAOK24.55018256
7CDK192.75464353
8CAMKK22.74487063
9PIK3CA2.69639455
10ICK2.44653121
11DYRK22.43857278
12EPHA42.35909529
13CDC72.11461054
14CDK122.08914513
15CASK1.97819590
16CAMKK11.90845806
17MAP3K91.82826468
18CCNB11.70503312
19ADRBK11.66949763
20MAP2K71.62174991
21PINK11.62151254
22BRD41.58044791
23WNK41.52031142
24MARK21.48439895
25INSRR1.44357801
26BMPR1B1.34359453
27SIK11.32845155
28IRAK21.31611887
29MAPK131.31084211
30TAOK31.31051282
31MAP2K41.28120359
32MAPK71.27170536
33WNK11.26489455
34EPHB21.16307055
35ABL21.15715124
36LATS11.14575564
37PRKD31.13770874
38MUSK1.12751979
39IRAK31.10792593
40MAP3K111.08647992
41MINK11.07842370
42PKN11.06725282
43MAP3K61.04725491
44MYLK1.02634724
45PNCK1.01899930
46STK381.00140241
47PRKCZ0.99423153
48RPS6KA20.97666426
49SIK20.97305675
50MAPK120.96514400
51CDK80.95714957
52NTRK30.95499193
53PAK60.94000246
54CAMK10.89659603
55EEF2K0.89448289
56NEK20.87994045
57RPS6KA40.85423858
58MAP3K40.85228251
59TYRO30.85187340
60PDK20.84850184
61UHMK10.84223765
62NTRK20.82645315
63MAP3K100.80230038
64CSNK1E0.80222495
65CHEK20.79013992
66DYRK30.75872493
67WNK30.75149992
68PHKG10.73998067
69PHKG20.73998067
70CSNK1D0.73494938
71OXSR10.70271766
72PRKAA10.69839723
73PDGFRB0.67721709
74PDK30.67681469
75PDK40.67681469
76TAF10.66034474
77RPS6KA60.65820807
78MAP3K130.64381312
79PLK10.63200817
80PRKAA20.63127258
81FGFR20.61460499
82CDK30.61373619
83SGK2230.61060487
84SGK4940.61060487
85MARK10.60604902
86MAP2K60.60409848
87CAMK40.60309261
88MAPK150.58768998
89PRKACG0.58155801
90TTK0.58100009
91STK160.56888041
92RPS6KL10.54659840
93RPS6KC10.54659840
94ATR0.54245134
95CDK90.53393658
96NTRK10.52843838
97AURKA0.52071059
98PLK40.50663956
99AKT10.50496022
100BCR0.49307355
101PRKCB0.48465792
102RPS6KA10.47957830
103RPS6KB20.47739911
104ERBB20.46277677
105PKN20.45491762
106STK390.45049888
107MTOR0.44525959
108NEK60.44486199
109BMX0.43538950
110CHUK0.42386314
111MAP3K70.42149615
112PRKDC0.42121777
113CDK20.41444727
114ADRBK20.41232079
115NEK10.40581795
116DYRK1A0.40109183
117PRKCH0.40041421
118RPS6KA30.39813561
119PTK60.39297424
120STK110.39236734
121MKNK20.37873235
122PTK20.36323971
123TIE10.36266141
124STK38L0.36097954
125ZAK0.35590772
126CSNK2A20.35526669
127HIPK20.35291892
128CDC42BPA0.35106562
129RPS6KA50.32948693
130SGK10.32862012
131AURKB0.32414224
132CHEK10.31810074
133AKT20.29721359
134RPS6KB10.29396227
135GSK3B0.29207136
136CAMK2D0.28128914
137MAPK140.27451037
138RIPK10.26905107
139STK30.26843086
140NME10.26116616
141DDR20.26093941
142FGFR10.25164438
143EPHB10.24535497
144PRKCI0.24498612
145PAK20.24430487
146TRIB30.24040359
147PLK20.23294124
148SGK30.23172361
149PRKCG0.22459824
150TNK20.21566863
151CDK50.21426139
152PRKACA0.20059191
153KSR10.19529188
154MAPK30.19234260
155MAPK100.19197853
156DYRK1B0.19018490
157PDPK10.18961093
158CAMK2A0.18699366
159CDK70.18056671

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.92924654
2Basal cell carcinoma_Homo sapiens_hsa052173.09655363
3Sulfur relay system_Homo sapiens_hsa041222.99178256
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.78185320
5Notch signaling pathway_Homo sapiens_hsa043302.66395419
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.47792766
7Vitamin B6 metabolism_Homo sapiens_hsa007502.40794750
8Homologous recombination_Homo sapiens_hsa034402.13372558
9Fanconi anemia pathway_Homo sapiens_hsa034602.12762056
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.05455138
11Phototransduction_Homo sapiens_hsa0474415.9746969
12Oxidative phosphorylation_Homo sapiens_hsa001901.79668942
13Base excision repair_Homo sapiens_hsa034101.54046805
14Caffeine metabolism_Homo sapiens_hsa002321.48689120
15Wnt signaling pathway_Homo sapiens_hsa043101.42537165
16Axon guidance_Homo sapiens_hsa043601.40085297
17Parkinsons disease_Homo sapiens_hsa050121.38503001
18Fatty acid biosynthesis_Homo sapiens_hsa000611.38242192
19Synaptic vesicle cycle_Homo sapiens_hsa047211.33217017
20Selenocompound metabolism_Homo sapiens_hsa004501.28336286
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.23490971
22Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.17125258
23Linoleic acid metabolism_Homo sapiens_hsa005911.16541789
24Olfactory transduction_Homo sapiens_hsa047401.16335440
25* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14451311
26DNA replication_Homo sapiens_hsa030301.08446804
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.06134489
28p53 signaling pathway_Homo sapiens_hsa041151.04883954
29Melanogenesis_Homo sapiens_hsa049161.04294558
30RNA polymerase_Homo sapiens_hsa030201.03976661
31Ether lipid metabolism_Homo sapiens_hsa005651.03669657
32Huntingtons disease_Homo sapiens_hsa050161.01977230
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.00943449
34Basal transcription factors_Homo sapiens_hsa030220.98265250
35Mismatch repair_Homo sapiens_hsa034300.91662073
36Retinol metabolism_Homo sapiens_hsa008300.90443128
37RNA degradation_Homo sapiens_hsa030180.89450122
38Nucleotide excision repair_Homo sapiens_hsa034200.88780331
39GABAergic synapse_Homo sapiens_hsa047270.88772019
40ErbB signaling pathway_Homo sapiens_hsa040120.85977534
41Protein export_Homo sapiens_hsa030600.85976927
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.84396900
43Cyanoamino acid metabolism_Homo sapiens_hsa004600.84127113
44Folate biosynthesis_Homo sapiens_hsa007900.83542421
45Pyrimidine metabolism_Homo sapiens_hsa002400.80616130
46Collecting duct acid secretion_Homo sapiens_hsa049660.78691532
47Arachidonic acid metabolism_Homo sapiens_hsa005900.73764625
48Taste transduction_Homo sapiens_hsa047420.73250253
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70904748
50Cholinergic synapse_Homo sapiens_hsa047250.70572268
51Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.67939044
52Steroid biosynthesis_Homo sapiens_hsa001000.66711353
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64382304
54Arginine and proline metabolism_Homo sapiens_hsa003300.64307265
55Circadian rhythm_Homo sapiens_hsa047100.61176122
56Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.55719577
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55139675
58Morphine addiction_Homo sapiens_hsa050320.54777137
59Alzheimers disease_Homo sapiens_hsa050100.54596779
60Glutamatergic synapse_Homo sapiens_hsa047240.53415179
61One carbon pool by folate_Homo sapiens_hsa006700.52833451
62Circadian entrainment_Homo sapiens_hsa047130.52550803
63MAPK signaling pathway_Homo sapiens_hsa040100.49538360
64Butanoate metabolism_Homo sapiens_hsa006500.49166392
65Spliceosome_Homo sapiens_hsa030400.48861225
66Metabolic pathways_Homo sapiens_hsa011000.48844998
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48405715
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.47532959
69Galactose metabolism_Homo sapiens_hsa000520.46676733
70Pyruvate metabolism_Homo sapiens_hsa006200.46650702
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.46556619
72ABC transporters_Homo sapiens_hsa020100.46009002
73Serotonergic synapse_Homo sapiens_hsa047260.44987269
74Rap1 signaling pathway_Homo sapiens_hsa040150.41486250
75Fatty acid elongation_Homo sapiens_hsa000620.40939584
76* Dopaminergic synapse_Homo sapiens_hsa047280.40789172
77Thyroid hormone synthesis_Homo sapiens_hsa049180.40230481
78Aldosterone synthesis and secretion_Homo sapiens_hsa049250.40160504
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40033108
80Oxytocin signaling pathway_Homo sapiens_hsa049210.39871084
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.39752683
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.39092446
83Purine metabolism_Homo sapiens_hsa002300.39051787
84Fatty acid metabolism_Homo sapiens_hsa012120.37287433
85mTOR signaling pathway_Homo sapiens_hsa041500.36727978
86Regulation of autophagy_Homo sapiens_hsa041400.36615798
87Glycerolipid metabolism_Homo sapiens_hsa005610.34908756
88cAMP signaling pathway_Homo sapiens_hsa040240.34744442
89Insulin secretion_Homo sapiens_hsa049110.33484746
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.32614942
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.31741295
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.30889431
93Renin secretion_Homo sapiens_hsa049240.30522372
94Prion diseases_Homo sapiens_hsa050200.30459587
95Lysine degradation_Homo sapiens_hsa003100.29245353
96Vitamin digestion and absorption_Homo sapiens_hsa049770.29006733
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.28889840
98Gastric acid secretion_Homo sapiens_hsa049710.28701281
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.28660344
100Inositol phosphate metabolism_Homo sapiens_hsa005620.28173805
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.28135675
102Dilated cardiomyopathy_Homo sapiens_hsa054140.27636984
103Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.26400750
104Arginine biosynthesis_Homo sapiens_hsa002200.26087286
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26084351
106Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.25360182
107Cardiac muscle contraction_Homo sapiens_hsa042600.25321928
108AMPK signaling pathway_Homo sapiens_hsa041520.25248678
109Maturity onset diabetes of the young_Homo sapiens_hsa049500.25228849
110Nicotine addiction_Homo sapiens_hsa050330.24817464
111ECM-receptor interaction_Homo sapiens_hsa045120.24707915
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.24143955
113Biosynthesis of amino acids_Homo sapiens_hsa012300.23996077
114Fructose and mannose metabolism_Homo sapiens_hsa000510.23568249
115Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.23109226
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.22807512
117Salivary secretion_Homo sapiens_hsa049700.22292114
118Glucagon signaling pathway_Homo sapiens_hsa049220.22163601
119Tight junction_Homo sapiens_hsa045300.21239514
120mRNA surveillance pathway_Homo sapiens_hsa030150.20727053
121Drug metabolism - other enzymes_Homo sapiens_hsa009830.19663973
122SNARE interactions in vesicular transport_Homo sapiens_hsa041300.18945238
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.18448080
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.18308683
125Mineral absorption_Homo sapiens_hsa049780.17860009
126Chemokine signaling pathway_Homo sapiens_hsa040620.17144145
127Protein digestion and absorption_Homo sapiens_hsa049740.16981514
128Ovarian steroidogenesis_Homo sapiens_hsa049130.16572051
129HIF-1 signaling pathway_Homo sapiens_hsa040660.16390764
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.15938716
131Insulin resistance_Homo sapiens_hsa049310.15872630
132Type II diabetes mellitus_Homo sapiens_hsa049300.15543539
133Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.15247716
134Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.14952907
135Alcoholism_Homo sapiens_hsa050340.14814380
136Vascular smooth muscle contraction_Homo sapiens_hsa042700.14766480
137Adipocytokine signaling pathway_Homo sapiens_hsa049200.13803529
138Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.13581082
139Nitrogen metabolism_Homo sapiens_hsa009100.12976489
140Calcium signaling pathway_Homo sapiens_hsa040200.12475983
141Hippo signaling pathway_Homo sapiens_hsa043900.11687641
142Phospholipase D signaling pathway_Homo sapiens_hsa040720.11048763
143Fat digestion and absorption_Homo sapiens_hsa049750.10570100
144Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.10188003
145Cocaine addiction_Homo sapiens_hsa050300.10038537
146Bile secretion_Homo sapiens_hsa049760.09292575
147alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.07655835
148Long-term potentiation_Homo sapiens_hsa047200.07454381
149Dorso-ventral axis formation_Homo sapiens_hsa043200.07387273
150PI3K-Akt signaling pathway_Homo sapiens_hsa041510.06710105
151PPAR signaling pathway_Homo sapiens_hsa033200.06110147
152Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.05916794
153N-Glycan biosynthesis_Homo sapiens_hsa005100.05883758
154Hedgehog signaling pathway_Homo sapiens_hsa043400.05762133
155Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.05659262
1562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.05175870
157Ras signaling pathway_Homo sapiens_hsa040140.05055929
158Amoebiasis_Homo sapiens_hsa051460.04607692

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