DRAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane repair (GO:0001778)5.49541171
2sarcomere organization (GO:0045214)5.25756375
3actin-myosin filament sliding (GO:0033275)5.06965846
4muscle filament sliding (GO:0030049)5.06965846
5negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.84408652
6negative regulation of cell size (GO:0045792)4.81685125
7protein maturation by protein folding (GO:0022417)4.69627055
8carnitine shuttle (GO:0006853)4.55730006
9negative regulation of potassium ion transmembrane transport (GO:1901380)4.51310151
10COPI coating of Golgi vesicle (GO:0048205)4.39984879
11Golgi transport vesicle coating (GO:0048200)4.39984879
12cardiac myofibril assembly (GO:0055003)4.34671354
13regulation of skeletal muscle contraction (GO:0014819)4.28491376
14tricarboxylic acid cycle (GO:0006099)4.17767347
15myofibril assembly (GO:0030239)4.10030111
16barbed-end actin filament capping (GO:0051016)4.07509568
17fatty acid transmembrane transport (GO:1902001)4.02685327
18positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.92789533
19carnitine transmembrane transport (GO:1902603)3.91441070
20cardiac muscle contraction (GO:0060048)3.86203224
21actin-mediated cell contraction (GO:0070252)3.85354164
22positive regulation of histone deacetylation (GO:0031065)3.83686929
23maternal placenta development (GO:0001893)3.81451378
24carnitine transport (GO:0015879)3.76296276
25amino-acid betaine transport (GO:0015838)3.76296276
26negative regulation of heart growth (GO:0061117)3.67957453
27negative regulation of cardiac muscle tissue growth (GO:0055022)3.67957453
28deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.67575409
29skin morphogenesis (GO:0043589)3.66152470
30protein retention in ER lumen (GO:0006621)3.64437287
31regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.59220497
32UV protection (GO:0009650)3.58142673
33maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.54468045
34actomyosin structure organization (GO:0031032)3.50097062
35nuclear envelope reassembly (GO:0031468)3.45316678
36mitotic nuclear envelope reassembly (GO:0007084)3.45316678
37regulation of fatty acid oxidation (GO:0046320)3.44212619
382-oxoglutarate metabolic process (GO:0006103)3.43999342
39striated muscle contraction (GO:0006941)3.42568771
40regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.37598503
41regulation of fatty acid beta-oxidation (GO:0031998)3.37470397
42skeletal muscle adaptation (GO:0043501)3.35574641
43cardiac muscle cell development (GO:0055013)3.34920720
44NIK/NF-kappaB signaling (GO:0038061)3.33429994
45negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.33225659
46pinocytosis (GO:0006907)3.31839706
47sarcoplasmic reticulum calcium ion transport (GO:0070296)3.30183746
48peptidyl-lysine dimethylation (GO:0018027)3.30038932
49positive regulation of myotube differentiation (GO:0010831)3.26643942
50stress fiber assembly (GO:0043149)3.25531662
51actin filament-based movement (GO:0030048)3.23384607
52positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)3.22658486
53focal adhesion assembly (GO:0048041)3.20929045
54cell-substrate adherens junction assembly (GO:0007045)3.20929045
55adherens junction assembly (GO:0034333)3.19236638
56skeletal muscle contraction (GO:0003009)3.18842418
574-hydroxyproline metabolic process (GO:0019471)3.17819998
58negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.14762259
59cardiac cell development (GO:0055006)3.14713262
60tricarboxylic acid metabolic process (GO:0072350)3.14066542
61lysine metabolic process (GO:0006553)3.13782598
62lysine catabolic process (GO:0006554)3.13782598
63protein localization to endosome (GO:0036010)3.10414468
64cell-substrate junction assembly (GO:0007044)3.08561311
65regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.08175363
66cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.08095303
67oxaloacetate metabolic process (GO:0006107)3.07301842
68Arp2/3 complex-mediated actin nucleation (GO:0034314)3.05908547
69heart trabecula formation (GO:0060347)3.05544875
70protein hydroxylation (GO:0018126)3.03862326
71creatine metabolic process (GO:0006600)3.01145312
72regulation of mammary gland epithelial cell proliferation (GO:0033599)2.99809781
73regulation of defense response to virus by virus (GO:0050690)2.98610812
74positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.97508031
75retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.97007939
76regulation of p38MAPK cascade (GO:1900744)2.96061348
77type B pancreatic cell proliferation (GO:0044342)2.95148258
78membrane raft organization (GO:0031579)2.91880464
79positive regulation of protein deacetylation (GO:0090312)2.91532841
80mitochondrial fusion (GO:0008053)2.90897886
81apoptotic cell clearance (GO:0043277)2.90525989
82negative regulation of fatty acid transport (GO:2000192)2.88527980
83modulation by symbiont of host cellular process (GO:0044068)2.88391160
84hemidesmosome assembly (GO:0031581)2.88104974
85ribosomal small subunit biogenesis (GO:0042274)2.87672417
862-deoxyribonucleotide biosynthetic process (GO:0009265)2.87620461
87deoxyribose phosphate biosynthetic process (GO:0046385)2.87620461
88GDP-mannose metabolic process (GO:0019673)2.86514646
89positive regulation of triglyceride biosynthetic process (GO:0010867)2.84998611
90glycogen catabolic process (GO:0005980)2.82872760
91peptidyl-proline hydroxylation (GO:0019511)2.82848237
92aspartate family amino acid catabolic process (GO:0009068)2.82564330
93modulation by virus of host process (GO:0019054)2.78102987
94negative regulation of nucleotide catabolic process (GO:0030812)2.77257017
95quaternary ammonium group transport (GO:0015697)2.76720617
96cytoskeletal anchoring at plasma membrane (GO:0007016)2.75325366
97cell communication by electrical coupling (GO:0010644)2.75195671
98positive regulation of fatty acid beta-oxidation (GO:0032000)2.75113387
99regulation of early endosome to late endosome transport (GO:2000641)2.74796350
100NADH metabolic process (GO:0006734)2.74506877
101pentose-phosphate shunt (GO:0006098)2.74318269
102hypotonic response (GO:0006971)2.73150868
103regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.69033222
104endothelial cell chemotaxis (GO:0035767)2.68030740
105epithelial cell-cell adhesion (GO:0090136)2.67850749
106activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.67676374
107nucleobase-containing small molecule interconversion (GO:0015949)2.67091503
108valine metabolic process (GO:0006573)2.66866755
109glycolytic process (GO:0006096)2.63965181
110positive regulation of fatty acid oxidation (GO:0046321)2.63814056
111regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.62701379
112apoptotic process involved in morphogenesis (GO:0060561)2.62413896
113establishment of viral latency (GO:0019043)2.62268248
114endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.62069325
115sodium ion export (GO:0071436)2.61699418
116positive regulation of blood vessel endothelial cell migration (GO:0043536)2.61341053
117muscle contraction (GO:0006936)2.61078288
118glycogen metabolic process (GO:0005977)2.60202767
119regulation of translational termination (GO:0006449)2.59801755
120glucan catabolic process (GO:0009251)2.59002968
121cell adhesion mediated by integrin (GO:0033627)2.58410124
122pyrimidine nucleoside salvage (GO:0043097)2.58332580
123pyrimidine-containing compound salvage (GO:0008655)2.58332580
124positive regulation of nuclease activity (GO:0032075)2.55873887
125virion assembly (GO:0019068)2.54934869
126regulation of tight junction assembly (GO:2000810)2.54128682
127regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.54081231
128regulation of type I interferon-mediated signaling pathway (GO:0060338)2.53631213
129cellular glucan metabolic process (GO:0006073)2.53361401
130glucan metabolic process (GO:0044042)2.53361401
131regulation of hippo signaling (GO:0035330)2.50921680
132striated muscle atrophy (GO:0014891)2.50480305
133fatty acid beta-oxidation (GO:0006635)2.50317976
134regulation of translational fidelity (GO:0006450)2.50186502
135platelet aggregation (GO:0070527)2.50050220
136positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.49774681
137hyaluronan catabolic process (GO:0030214)2.49579294
138virion attachment to host cell (GO:0019062)2.48774487
139adhesion of symbiont to host cell (GO:0044650)2.48774487
140activation of Rac GTPase activity (GO:0032863)2.48664860
141peptidyl-arginine omega-N-methylation (GO:0035247)2.47854929
142ventricular cardiac muscle cell action potential (GO:0086005)2.47800539
143cellular response to osmotic stress (GO:0071470)2.47376958
144chaperone mediated protein folding requiring cofactor (GO:0051085)2.46958330
145gluconeogenesis (GO:0006094)2.46662528
146regulation of apoptotic process involved in morphogenesis (GO:1902337)2.46570746
147positive regulation of glycogen biosynthetic process (GO:0045725)2.46397378
148regulation of superoxide anion generation (GO:0032928)2.45856854
149positive regulation of lamellipodium assembly (GO:0010592)2.45485267
150regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.44868099
151positive regulation of monocyte chemotaxis (GO:0090026)2.44218736
152glucose catabolic process (GO:0006007)2.43349828
153positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.43246941
154low-density lipoprotein particle clearance (GO:0034383)2.42827251
155actin filament depolymerization (GO:0030042)2.42566671
156viral protein processing (GO:0019082)2.42359833
157negative regulation of necroptotic process (GO:0060546)2.41909102
158mature B cell differentiation involved in immune response (GO:0002313)2.38828464
159glial cell migration (GO:0008347)2.38240202
160lipopolysaccharide-mediated signaling pathway (GO:0031663)2.37359220
161protein heterotrimerization (GO:0070208)2.37278852
162negative regulation of epidermal growth factor receptor signaling pathway (GO:0042059)2.36328430
163positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.35931320
164cellular response to virus (GO:0098586)2.35930477
165negative regulation of ERBB signaling pathway (GO:1901185)2.35798513
166regulation of monocyte chemotaxis (GO:0090025)2.35145476
167regulation of necrotic cell death (GO:0010939)2.33820979
168deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.32550798
169negative regulation of nitric oxide biosynthetic process (GO:0045019)2.32405701
170response to peptidoglycan (GO:0032494)2.32111981
171regulation of metalloenzyme activity (GO:0048552)2.31928806
172response to progesterone (GO:0032570)2.31064106
173negative regulation of erythrocyte differentiation (GO:0045647)2.30678592
174positive regulation of macrophage differentiation (GO:0045651)2.30206041
175endodermal cell differentiation (GO:0035987)2.30078333
176decidualization (GO:0046697)2.29913941
177positive regulation of interleukin-8 secretion (GO:2000484)2.29529902
178adhesion of symbiont to host (GO:0044406)2.27431660
179fibril organization (GO:0097435)2.27211049
180negative regulation of skeletal muscle tissue development (GO:0048642)2.25789669
181cortical actin cytoskeleton organization (GO:0030866)2.25685492
182response to gravity (GO:0009629)2.25400720
183actin nucleation (GO:0045010)2.24645055
184regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.24422342
185type I interferon signaling pathway (GO:0060337)2.23116362
186cellular response to type I interferon (GO:0071357)2.23116362
187activation of MAPKKK activity (GO:0000185)2.22473355
188extracellular fibril organization (GO:0043206)2.19651784
189lipopolysaccharide biosynthetic process (GO:0009103)2.19406078
190regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.18443194
191response to type I interferon (GO:0034340)2.18365201
192protein targeting to plasma membrane (GO:0072661)2.16953393

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.05170695
2RARG_19884340_ChIP-ChIP_MEFs_Mouse2.78511217
3LXR_22292898_ChIP-Seq_THP-1_Human2.68745834
4TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.56553523
5ZNF263_19887448_ChIP-Seq_K562_Human2.50287050
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.49898894
7MYC_22102868_ChIP-Seq_BL_Human2.45609340
8KDM2B_26808549_Chip-Seq_SUP-B15_Human2.44248179
9KDM2B_26808549_Chip-Seq_DND41_Human2.34703003
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.32491482
11ELK3_25401928_ChIP-Seq_HUVEC_Human2.30884935
12VDR_21846776_ChIP-Seq_THP-1_Human2.19492487
13TCF7_22412390_ChIP-Seq_EML_Mouse2.15794131
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.12998906
15RACK7_27058665_Chip-Seq_MCF-7_Human2.06500269
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.03887445
17KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.02920188
18ZFP281_18757296_ChIP-ChIP_E14_Mouse1.98906841
19ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.98230384
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.91228247
21CLOCK_20551151_ChIP-Seq_293T_Human1.87912978
22RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.86355701
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78597404
24* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.75740780
25KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.72547967
26PPARA_22158963_ChIP-Seq_LIVER_Mouse1.71803479
27TP63_17297297_ChIP-ChIP_HaCaT_Human1.70510366
28TBX20_22328084_ChIP-Seq_HEART_Mouse1.70247714
29TBX20_22080862_ChIP-Seq_HEART_Mouse1.70247714
30STAT6_21828071_ChIP-Seq_BEAS2B_Human1.69023486
31BP1_19119308_ChIP-ChIP_Hs578T_Human1.67672574
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.66228687
33P68_20966046_ChIP-Seq_HELA_Human1.66071775
34KDM2B_26808549_Chip-Seq_K562_Human1.65761760
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.63909882
36ELF1_20517297_ChIP-Seq_JURKAT_Human1.61350377
37ATF3_27146783_Chip-Seq_COLON_Human1.60574871
38TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.60215212
39CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.57516465
40* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.57134496
41MYC_18358816_ChIP-ChIP_MESCs_Mouse1.55232368
42KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.54337142
43CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.53159507
44* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.51831216
45* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.51681344
46ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.50782490
47RXR_22158963_ChIP-Seq_LIVER_Mouse1.50474305
48CREB1_26743006_Chip-Seq_LNCaP_Human1.46670872
49KDM2B_26808549_Chip-Seq_JURKAT_Human1.46047635
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.44396215
51HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.43756989
52CTCF_21964334_ChIP-Seq_BJAB-B_Human1.43750978
53MAF_26560356_Chip-Seq_TH1_Human1.43303999
54JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.43266364
55* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.43165389
56NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.42795563
57TET1_21451524_ChIP-Seq_MESCs_Mouse1.42365924
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.42181079
59BCL6_27268052_Chip-Seq_Bcells_Human1.41614951
60* MYC_18555785_ChIP-Seq_MESCs_Mouse1.41453584
61SMC4_20622854_ChIP-Seq_HELA_Human1.40972775
62BCOR_27268052_Chip-Seq_Bcells_Human1.40501202
63ELF1_17652178_ChIP-ChIP_JURKAT_Human1.39841779
64SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.38710056
65TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.38132730
66STAT3_1855785_ChIP-Seq_MESCs_Mouse1.37990801
67CTCF_27219007_Chip-Seq_ERYTHROID_Human1.36944034
68UTX_26944678_Chip-Seq_JUKART_Human1.35877415
69SA1_27219007_Chip-Seq_ERYTHROID_Human1.35720433
70RUNX1_22412390_ChIP-Seq_EML_Mouse1.35594056
71NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.34669060
72ZFP281_27345836_Chip-Seq_ESCs_Mouse1.33715320
73MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.33100369
74CTCF_21964334_Chip-Seq_Bcells_Human1.32863381
75ESR2_21235772_ChIP-Seq_MCF-7_Human1.29600601
76SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.28946056
77ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.28365201
78E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.27946711
79STAT4_19710469_ChIP-ChIP_TH1__Mouse1.27875699
80KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.27754776
81WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.27477677
82RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.27100710
83TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.26284394
84PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.25684524
85THAP11_20581084_ChIP-Seq_MESCs_Mouse1.25404236
86SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.24555412
87DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24444488
88TP63_22573176_ChIP-Seq_HFKS_Human1.24220231
89SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.24182991
90DNAJC2_21179169_ChIP-ChIP_NT2_Human1.23731633
91NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.23563805
92MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.23422088
93XRN2_22483619_ChIP-Seq_HELA_Human1.23091082
94CTCF_27219007_Chip-Seq_Bcells_Human1.22989268
95SRY_22984422_ChIP-ChIP_TESTIS_Rat1.21550896
96HIF1A_21447827_ChIP-Seq_MCF-7_Human1.21456463
97NCOR1_26117541_ChIP-Seq_K562_Human1.20680075
98PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19439087
99MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.19419516
100* TP53_22127205_ChIP-Seq_IMR90_Human1.18809656
101KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18068187
102TRIM28_21343339_ChIP-Seq_HEK293_Human1.17619027
103RUNX1_27514584_Chip-Seq_MCF-7_Human1.14564085
104MAF_26560356_Chip-Seq_TH2_Human1.14467455
105EGR1_19374776_ChIP-ChIP_THP-1_Human1.14093604
106SPI1_20517297_ChIP-Seq_HL60_Human1.13990669
107VDR_24763502_ChIP-Seq_THP-1_Human1.13634132
108TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.11376305
109NELFA_20434984_ChIP-Seq_ESCs_Mouse1.10830653
110EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.10659365
111MYC_19079543_ChIP-ChIP_MESCs_Mouse1.10626154
112SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10417251
113CTCF_18555785_ChIP-Seq_MESCs_Mouse1.09991187
114LXR_22158963_ChIP-Seq_LIVER_Mouse1.09610716
115YY1_22570637_ChIP-Seq_MALME-3M_Human1.08971430
116* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08562837
117ZFX_18555785_ChIP-Seq_MESCs_Mouse1.07901791
118PHF8_20622854_ChIP-Seq_HELA_Human1.07017880
119NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06868371
120SA1_27219007_Chip-Seq_Bcells_Human1.06672101
121* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.06498263
122* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.06227922
123CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05799365
124TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.05559282
125GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04403096
126E2F1_20622854_ChIP-Seq_HELA_Human1.03988671
127DCP1A_22483619_ChIP-Seq_HELA_Human1.03322203
128MYB_21317192_ChIP-Seq_ERMYB_Mouse1.03196889
129SMC1_22415368_ChIP-Seq_MEFs_Mouse1.03044851
130NANOG_18555785_ChIP-Seq_MESCs_Mouse1.02293154
131CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01689057
132PU.1_20513432_ChIP-Seq_Bcells_Mouse1.01444755
133STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01353596
134CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01326129
135TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01019600
136KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00650615
137CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00162162
138SPI1_23547873_ChIP-Seq_NB4_Human0.99978607
139BRD4_27068464_Chip-Seq_AML-cells_Mouse0.99972091
140MYC_19030024_ChIP-ChIP_MESCs_Mouse0.99907963
141* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.99855857
142TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97595139
143GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97360046
144FOXP1_21924763_ChIP-Seq_HESCs_Human0.97233057
145SPI1_23127762_ChIP-Seq_K562_Human0.96163711
146ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95533166
147CTCF_26484167_Chip-Seq_Bcells_Mouse0.95063880

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue4.66538688
2MP0000751_myopathy4.41501939
3MP0002837_dystrophic_cardiac_calcinosis4.10326125
4MP0003705_abnormal_hypodermis_morpholog3.73739084
5MP0000749_muscle_degeneration3.42339359
6MP0004084_abnormal_cardiac_muscle3.03159610
7MP0004036_abnormal_muscle_relaxation2.90307623
8MP0004087_abnormal_muscle_fiber2.89413123
9MP0005451_abnormal_body_composition2.80272058
10MP0004130_abnormal_muscle_cell2.80091566
11MP0000750_abnormal_muscle_regeneration2.75790712
12MP0004145_abnormal_muscle_electrophysio2.64794095
13MP0002269_muscular_atrophy2.59896439
14MP0005330_cardiomyopathy2.58747007
15MP0003436_decreased_susceptibility_to2.54669888
16MP0002106_abnormal_muscle_physiology2.38875846
17MP0000759_abnormal_skeletal_muscle2.33271059
18MP0000858_altered_metastatic_potential2.29501370
19MP0000747_muscle_weakness2.29402482
20MP0008438_abnormal_cutaneous_collagen2.27538015
21MP0001542_abnormal_bone_strength2.11993204
22MP0004233_abnormal_muscle_weight2.10964665
23MP0008260_abnormal_autophagy2.00426752
24MP0004185_abnormal_adipocyte_glucose2.00207788
25MP0006082_CNS_inflammation1.95932059
26MP0005369_muscle_phenotype1.92620823
27MP0010630_abnormal_cardiac_muscle1.89792019
28MP0005666_abnormal_adipose_tissue1.86928746
29MP0005620_abnormal_muscle_contractility1.86127821
30MP0008961_abnormal_basal_metabolism1.80728039
31MP0004947_skin_inflammation1.79674324
32MP0005464_abnormal_platelet_physiology1.77031840
33MP0004215_abnormal_myocardial_fiber1.76934443
34MP0004510_myositis1.76802855
35MP0003806_abnormal_nucleotide_metabolis1.76496348
36MP0000733_abnormal_muscle_development1.75954177
37MP0005257_abnormal_intraocular_pressure1.74718318
38MP0009333_abnormal_splenocyte_physiolog1.73830036
39MP0005623_abnormal_meninges_morphology1.64295071
40MP0003566_abnormal_cell_adhesion1.60453699
41MP0001533_abnormal_skeleton_physiology1.58919483
42MP0002972_abnormal_cardiac_muscle1.57504270
43MP0003279_aneurysm1.56779478
44MP0002148_abnormal_hypersensitivity_rea1.56254289
45MP0002877_abnormal_melanocyte_morpholog1.55515257
46MP0001544_abnormal_cardiovascular_syste1.55305470
47MP0005385_cardiovascular_system_phenoty1.55305470
48MP0005000_abnormal_immune_tolerance1.50529631
49MP0002060_abnormal_skin_morphology1.49491046
50MP0009785_altered_susceptibility_to1.48174825
51MP0009278_abnormal_bone_marrow1.47581097
52MP0005375_adipose_tissue_phenotype1.47527914
53MP0005025_abnormal_response_to1.45854077
54MP0005275_abnormal_skin_tensile1.43062636
55MP0003448_altered_tumor_morphology1.43008955
56MP0009840_abnormal_foam_cell1.42898369
57MP0002419_abnormal_innate_immunity1.39131953
58MP0008775_abnormal_heart_ventricle1.38405307
59MP0000685_abnormal_immune_system1.37069034
60MP0001835_abnormal_antigen_presentation1.36981372
61MP0003283_abnormal_digestive_organ1.36557701
62MP0010352_gastrointestinal_tract_polyps1.35960633
63MP0003950_abnormal_plasma_membrane1.35809973
64MP0003453_abnormal_keratinocyte_physiol1.35786340
65MP0005501_abnormal_skin_physiology1.35142588
66MP0001958_emphysema1.35081644
67MP0006036_abnormal_mitochondrial_physio1.34352225
68MP0005670_abnormal_white_adipose1.32770807
69MP0003137_abnormal_impulse_conducting1.32397490
70MP0003221_abnormal_cardiomyocyte_apopto1.31933561
71MP0002909_abnormal_adrenal_gland1.31379438
72MP0001243_abnormal_dermal_layer1.28416606
73MP0000604_amyloidosis1.27513242
74MP0003300_gastrointestinal_ulcer1.26689877
75MP0002234_abnormal_pharynx_morphology1.25752131
76MP0001853_heart_inflammation1.24832872
77MP0003763_abnormal_thymus_physiology1.24446846
78MP0004858_abnormal_nervous_system1.24324958
79MP0002998_abnormal_bone_remodeling1.24158346
80MP0005390_skeleton_phenotype1.22373002
81MP0001849_ear_inflammation1.18171815
82MP0000013_abnormal_adipose_tissue1.18080642
83MP0006138_congestive_heart_failure1.16778987
84MP0002723_abnormal_immune_serum1.13839430
85MP0002796_impaired_skin_barrier1.12395932
86MP0004484_altered_response_of1.10986214
87MP0002420_abnormal_adaptive_immunity1.10973832
88MP0001819_abnormal_immune_cell1.09977786
89MP0002452_abnormal_antigen_presenting1.09943039
90MP0005076_abnormal_cell_differentiation1.08698433
91MP0000003_abnormal_adipose_tissue1.08176920
92MP0000343_altered_response_to1.07989224
93MP0002108_abnormal_muscle_morphology1.06455085
94MP0002332_abnormal_exercise_endurance1.04721293
95MP0003172_abnormal_lysosome_physiology1.02930146
96MP0003303_peritoneal_inflammation1.01847198
97MP0005410_abnormal_fertilization1.01841620
98MP0009053_abnormal_anal_canal1.00896096
99MP0005671_abnormal_response_to1.00028280
100MP0000678_abnormal_parathyroid_gland0.99887997
101MP0000266_abnormal_heart_morphology0.98327846
102MP0009384_cardiac_valve_regurgitation0.96726235
103MP0002089_abnormal_postnatal_growth/wei0.95328550
104MP0001216_abnormal_epidermal_layer0.92633015
105MP0005164_abnormal_response_to0.92095249
106MP0005387_immune_system_phenotype0.90893945
107MP0001790_abnormal_immune_system0.90893945
108MP0002398_abnormal_bone_marrow0.90515790
109MP0005023_abnormal_wound_healing0.90497573
110MP0002971_abnormal_brown_adipose0.90141557
111MP0005166_decreased_susceptibility_to0.89621014
112MP0005058_abnormal_lysosome_morphology0.89405314
113MP0005508_abnormal_skeleton_morphology0.87370331
114MP0000490_abnormal_crypts_of0.86730855
115MP0002933_joint_inflammation0.86185850
116MP0002429_abnormal_blood_cell0.85772070
117MP0001873_stomach_inflammation0.85537842
118MP0001845_abnormal_inflammatory_respons0.85424493
119MP0002405_respiratory_system_inflammati0.85364043
120MP0000716_abnormal_immune_system0.85216872
121MP0003828_pulmonary_edema0.84819302
122MP0004085_abnormal_heartbeat0.84422533
123MP0008469_abnormal_protein_level0.84128882
124MP0003191_abnormal_cellular_cholesterol0.84060598
125MP0003795_abnormal_bone_structure0.83395270
126MP0005083_abnormal_biliary_tract0.82029990
127MP0003045_fibrosis0.81757039
128MP0004808_abnormal_hematopoietic_stem0.80884747
129MP0005621_abnormal_cell_physiology0.80524386
130MP0002722_abnormal_immune_system0.80051440
131MP0001800_abnormal_humoral_immune0.79572526
132MP0010368_abnormal_lymphatic_system0.79413218
133MP0003075_altered_response_to0.79235902
134MP0002653_abnormal_ependyma_morphology0.78633245
135MP0000681_abnormal_thyroid_gland0.78048620
136MP0000358_abnormal_cell_content/0.77755071
137MP0002128_abnormal_blood_circulation0.77059972
138MP0005167_abnormal_blood-brain_barrier0.76688010
139MP0005319_abnormal_enzyme/_coenzyme0.76256673
140MP0004272_abnormal_basement_membrane0.75367249
141MP0003091_abnormal_cell_migration0.67436233
142MP0009115_abnormal_fat_cell0.66611075
143MP0009780_abnormal_chondrocyte_physiolo0.65661168
144MP0002970_abnormal_white_adipose0.64897132
145MP0000767_abnormal_smooth_muscle0.64081187
146MP0005165_increased_susceptibility_to0.61494094
147MP0004859_abnormal_synaptic_plasticity0.60623906
148MP0002925_abnormal_cardiovascular_devel0.59199151
149MP0005503_abnormal_tendon_morphology0.58845162
150MP0002896_abnormal_bone_mineralization0.58282028
151MP0003329_amyloid_beta_deposits0.57412691
152MP0008770_decreased_survivor_rate0.57083552
153MP0002078_abnormal_glucose_homeostasis0.56153025
154MP0000534_abnormal_ureter_morphology0.55859275
155MP0001348_abnormal_lacrimal_gland0.54612699
156MP0005334_abnormal_fat_pad0.53146394
157MP0010234_abnormal_vibrissa_follicle0.53028843
158MP0001545_abnormal_hematopoietic_system0.52843523
159MP0005397_hematopoietic_system_phenotyp0.52843523
160MP0004197_abnormal_fetal_growth/weight/0.52757496
161MP0002127_abnormal_cardiovascular_syste0.52584149
162MP0001614_abnormal_blood_vessel0.52544295

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)5.42543975
2Exercise-induced muscle cramps (HP:0003710)5.39077093
3Myoglobinuria (HP:0002913)4.50668378
4Sudden death (HP:0001699)4.43053158
5Vertebral compression fractures (HP:0002953)4.29846045
6Increased connective tissue (HP:0009025)4.15877313
7Type 1 muscle fiber predominance (HP:0003803)4.14684426
8Muscle fiber splitting (HP:0003555)4.11301581
9Difficulty running (HP:0009046)4.04983347
10Hyporeflexia of lower limbs (HP:0002600)4.00737132
11Difficulty climbing stairs (HP:0003551)3.97509974
12Calf muscle hypertrophy (HP:0008981)3.94942598
13Asymmetric septal hypertrophy (HP:0001670)3.89566149
14Muscle hypertrophy of the lower extremities (HP:0008968)3.83767725
15Ventricular tachycardia (HP:0004756)3.61666148
16Muscle fiber inclusion bodies (HP:0100299)3.50296813
17Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.42312496
18Abnormality of the calf musculature (HP:0001430)3.37554316
19Increased variability in muscle fiber diameter (HP:0003557)3.30972662
20EMG: myopathic abnormalities (HP:0003458)3.26620288
21Protrusio acetabuli (HP:0003179)3.25265739
22Bundle branch block (HP:0011710)3.22602771
23Abnormality of the left ventricular outflow tract (HP:0011103)3.22267715
24Subaortic stenosis (HP:0001682)3.22267715
25Myotonia (HP:0002486)3.22240437
26Rhabdomyolysis (HP:0003201)3.20220764
27Distal lower limb muscle weakness (HP:0009053)3.18768883
28Ulnar deviation of the wrist (HP:0003049)3.18257505
29Abnormality of skeletal muscle fiber size (HP:0012084)3.15865978
30Round ear (HP:0100830)3.13922581
31Cerebral aneurysm (HP:0004944)3.02270552
32Achilles tendon contracture (HP:0001771)3.00650692
33Muscle stiffness (HP:0003552)2.97283365
34Fragile skin (HP:0001030)2.87266410
35Short nail (HP:0001799)2.82992610
36Abnormality of the Achilles tendon (HP:0005109)2.82780038
37Mildly elevated creatine phosphokinase (HP:0008180)2.78129469
38Right ventricular cardiomyopathy (HP:0011663)2.76913170
39Distal arthrogryposis (HP:0005684)2.76199026
40Limb-girdle muscle atrophy (HP:0003797)2.72984282
41Atrophic scars (HP:0001075)2.69600906
42Nemaline bodies (HP:0003798)2.68337537
43Myopathic facies (HP:0002058)2.67897348
44Abnormality of liposaccharide metabolism (HP:0010968)2.67847103
45Abnormality of glycosphingolipid metabolism (HP:0004343)2.67847103
46Abnormality of glycolipid metabolism (HP:0010969)2.67847103
47Lipoatrophy (HP:0100578)2.62243900
48Elbow flexion contracture (HP:0002987)2.60136747
49Cervical subluxation (HP:0003308)2.52934383
50Frequent falls (HP:0002359)2.49445885
51Entropion (HP:0000621)2.49257612
52Broad metatarsal (HP:0001783)2.47685925
53Distal upper limb amyotrophy (HP:0007149)2.47249651
54Upper limb amyotrophy (HP:0009129)2.47249651
55Reduced subcutaneous adipose tissue (HP:0003758)2.45568419
56Abnormal atrioventricular conduction (HP:0005150)2.44203198
57Centrally nucleated skeletal muscle fibers (HP:0003687)2.43102055
58Heart block (HP:0012722)2.41374874
59Osteolytic defects of the hand bones (HP:0009699)2.41127488
60Osteolytic defects of the phalanges of the hand (HP:0009771)2.41127488
61EMG: neuropathic changes (HP:0003445)2.38694794
62Rough bone trabeculation (HP:0100670)2.37838468
63Axonal loss (HP:0003447)2.35531094
64Atrioventricular block (HP:0001678)2.33649753
65Atrial fibrillation (HP:0005110)2.33251469
66Wormian bones (HP:0002645)2.31458848
67Follicular hyperkeratosis (HP:0007502)2.30283031
68Primary atrial arrhythmia (HP:0001692)2.30039675
69Supraventricular arrhythmia (HP:0005115)2.28133618
70Supraventricular tachycardia (HP:0004755)2.25585221
71Trismus (HP:0000211)2.25206133
72Calcaneovalgus deformity (HP:0001848)2.23214542
73Abnormality of the nasal mucosa (HP:0000433)2.23122463
74Joint stiffness (HP:0001387)2.22760232
75Scapular winging (HP:0003691)2.21921025
76Ventricular fibrillation (HP:0001663)2.20791628
77Abnormality of dentin (HP:0010299)2.19266913
78Biconcave vertebral bodies (HP:0004586)2.19074171
79Abnormality of the distal phalanges of the toes (HP:0010182)2.17893249
80Spinal rigidity (HP:0003306)2.16197944
81Conjunctival hamartoma (HP:0100780)2.15905917
82Insomnia (HP:0100785)2.14849416
83Ventricular arrhythmia (HP:0004308)2.14683518
84Multiple enchondromatosis (HP:0005701)2.13283638
85Bladder diverticulum (HP:0000015)2.11600268
86Dysostosis multiplex (HP:0000943)2.11066148
87Broad face (HP:0000283)2.10588319
88Dilated cardiomyopathy (HP:0001644)2.09736455
89Premature rupture of membranes (HP:0001788)2.09679086
90Hamartoma of the eye (HP:0010568)2.08817414
91Cellulitis (HP:0100658)2.08205342
92Mitral regurgitation (HP:0001653)2.08057882
93Hypertensive crisis (HP:0100735)2.07402055
94Shallow orbits (HP:0000586)2.06919739
95Hyperacusis (HP:0010780)2.05260875
96Nasal polyposis (HP:0100582)2.04817480
97Dilatation of the ascending aorta (HP:0005111)2.03955737
98Lymphangioma (HP:0100764)2.03089345
99Abnormality of the lower motor neuron (HP:0002366)2.02939168
100Genu recurvatum (HP:0002816)2.02257951
101Spondylolisthesis (HP:0003302)2.01840205
102Blue sclerae (HP:0000592)2.01666641
103Deformed tarsal bones (HP:0008119)2.01336956
104Upper motor neuron abnormality (HP:0002127)1.99031670
105Neck muscle weakness (HP:0000467)1.98810296
106Abnormality of macrophages (HP:0004311)1.98762728
107Palpitations (HP:0001962)1.98546691
108Hand muscle atrophy (HP:0009130)1.98479091
109Ketoacidosis (HP:0001993)1.98475066
110Distal lower limb amyotrophy (HP:0008944)1.98323160
111Aortic dissection (HP:0002647)1.96304139
112J-shaped sella turcica (HP:0002680)1.96266062
113Long toe (HP:0010511)1.95952255
114Generalized muscle weakness (HP:0003324)1.94819567
115Hypercortisolism (HP:0001578)1.94738714
116Ankle contracture (HP:0006466)1.94696079
117Aneurysm (HP:0002617)1.94116755
118Interstitial pulmonary disease (HP:0006530)1.93925838
119Testicular atrophy (HP:0000029)1.93359247
120Increased density of long bones (HP:0006392)1.93080334
121Rectal prolapse (HP:0002035)1.90984467
122Dysmetric saccades (HP:0000641)1.89486965
123Natal tooth (HP:0000695)1.88859101
124Nail dystrophy (HP:0008404)1.87022087
125Facial diplegia (HP:0001349)1.86867438
126Rapidly progressive (HP:0003678)1.84967645
127Progressive muscle weakness (HP:0003323)1.84900499
128Limb-girdle muscle weakness (HP:0003325)1.84821935
129Polycythemia (HP:0001901)1.83135641
130Generalized amyotrophy (HP:0003700)1.81336415
131Hepatosplenomegaly (HP:0001433)1.81156479
132Angiofibromas (HP:0010615)1.80219249
133Adenoma sebaceum (HP:0009720)1.80219249
134Nuclear cataract (HP:0100018)1.79733345
135Vascular tortuosity (HP:0004948)1.79659639
136Elevated erythrocyte sedimentation rate (HP:0003565)1.79311652
137Increased serum ferritin (HP:0003281)1.78854523
138Neurofibrillary tangles (HP:0002185)1.77815026
139Obstructive lung disease (HP:0006536)1.76596213
140Chronic obstructive pulmonary disease (HP:0006510)1.76596213
141Proximal amyotrophy (HP:0007126)1.75355426
142Mitral valve prolapse (HP:0001634)1.74752635
143Ketosis (HP:0001946)1.74275818
144Abnormality of the calcaneus (HP:0008364)1.74168926
145Stridor (HP:0010307)1.73331757
146Supranuclear gaze palsy (HP:0000605)1.71515689
147Cerebral inclusion bodies (HP:0100314)1.70890172
148Petechiae (HP:0000967)1.70590204
149Abnormality of the umbilical cord (HP:0010881)1.69897293
150Ulnar bowing (HP:0003031)1.69386331
151Cholecystitis (HP:0001082)1.69238451
152Abnormal gallbladder physiology (HP:0012438)1.69238451
153Aortic aneurysm (HP:0004942)1.69024770
154Hyperparathyroidism (HP:0000843)1.68878028
155Abnormal trabecular bone morphology (HP:0100671)1.68491629
156Gout (HP:0001997)1.68392574
157Prolonged QT interval (HP:0001657)1.67746409
158Long palpebral fissure (HP:0000637)1.67638287
159Upper limb muscle weakness (HP:0003484)1.67571563
160Slender build (HP:0001533)1.66401164
161Mesangial abnormality (HP:0001966)1.66119628
162Disproportionate tall stature (HP:0001519)1.65925521
163Prolonged neonatal jaundice (HP:0006579)1.65739517
164Lower limb amyotrophy (HP:0007210)1.65365740
165Glucose intolerance (HP:0000833)1.65187297
166Acanthosis nigricans (HP:0000956)1.64978836
167Hypertriglyceridemia (HP:0002155)1.62190928
168Short clavicles (HP:0000894)1.62099921
169Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.62051237
170Bowed forearm bones (HP:0003956)1.61844997
171Bowing of the arm (HP:0006488)1.61844997
172Onycholysis (HP:0001806)1.61590112
173Selective tooth agenesis (HP:0001592)1.57341052
174Coxa vara (HP:0002812)1.55506993
175Hypoventilation (HP:0002791)1.55091116

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.88132454
2NME24.03667088
3TTN4.02688393
4PKN23.92820862
5TESK23.74506446
6IRAK33.32667067
7EEF2K2.88269780
8EPHA22.57439561
9PRKD32.57019786
10ERN12.49555660
11PDK42.37902078
12PDK32.37902078
13LIMK12.35315177
14PHKG12.28175418
15PHKG22.28175418
16TAOK22.22390222
17PIM22.15898006
18PRPF4B2.14424753
19ICK2.06290008
20MAP3K102.06273330
21ARAF1.98229645
22RIPK11.84176753
23PDGFRA1.83393077
24NEK11.80611004
25SMG11.80526095
26LMTK21.73395092
27VRK21.72403681
28DMPK1.71148660
29KDR1.68095930
30OBSCN1.52540659
31TESK11.51658070
32LRRK21.50528993
33PTK61.47939897
34BCKDK1.47082772
35ILK1.42993264
36PINK11.41271548
37BMX1.37986330
38TAOK11.31461312
39MST1R1.28769158
40SIK11.28286554
41MAP2K31.26782824
42KSR21.21506684
43DDR21.20267632
44TYRO31.19479420
45NTRK11.16304625
46MAP3K71.15666246
47MAPKAPK31.15213211
48ABL21.13589702
49BUB11.10423807
50PDK21.08966357
51MAP3K111.06419957
52LATS21.01894951
53PAK41.00049587
54CAMKK10.98152079
55STK380.92432440
56ALK0.87155032
57DAPK30.86281070
58BRAF0.85733526
59MAP3K140.83509323
60STK100.82596879
61MAP3K80.82021652
62ERBB40.81369381
63MYLK0.80605915
64PTK2B0.80430046
65PRKCH0.80146342
66CDK80.79195928
67MAP3K130.78098312
68PAK60.75993370
69DYRK1B0.75793691
70IRAK40.75019190
71PRKD20.74769487
72PAK10.74581747
73JAK30.73562937
74PRKD10.72491726
75RET0.69912255
76AURKA0.67553637
77MET0.65407263
78PAK20.64090899
79MTOR0.64021005
80DAPK10.63625696
81GRK70.62755666
82EPHB10.62691587
83FLT30.62444905
84MAP3K10.62307932
85NME10.59239621
86SCYL20.57386940
87MAPK120.57141589
88MAP4K10.56411137
89TGFBR20.55935269
90PDPK10.55742397
91PTK20.55356692
92PDK10.54825117
93MAP3K120.54565112
94PRKAA10.51271400
95EPHB20.51050650
96IKBKB0.50121514
97GRK60.49390860
98FGFR40.49311879
99TYK20.48923818
100ROCK20.48913810
101MAP2K60.47641359
102MAP3K90.45987781
103RPS6KA10.45753975
104MAPK110.45555023
105RPS6KA20.45497904
106IRAK20.45373411
107PRKG20.44695627
108RPS6KL10.43829647
109RPS6KC10.43829647
110RPS6KA40.43556758
111CDK11A0.43069947
112PDGFRB0.42511080
113CDK140.42191790
114SIK30.41774752
115NEK20.41356154
116CAMK1D0.40620941
117SIK20.40378809
118ROCK10.40107703
119CAMK1G0.39962656
120RPS6KA60.39805292
121MAPKAPK20.39193192
122TRPM70.39031004
123IKBKE0.38697114
124PIK3CG0.38037523
125ZAP700.37403509
126MAP2K40.37146706
127CDK150.36729613
128CAMK2G0.36682906
129CDC42BPA0.36390713
130HIPK20.36357600
131DAPK20.36318305
132PAK30.35065222
133MAP2K10.34774034
134AKT20.34695138
135EIF2AK10.34429762
136CDK70.34214688
137TBK10.34054292
138JAK20.33918142
139WNK40.33223919
140KIT0.32829355
141MAP3K30.32586160
142CSF1R0.32579862
143MOS0.31092781
144CAMK40.31011349
145CSK0.30447189
146STK240.30079480
147MAP2K20.29925001

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.92174725
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.40826568
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.84706051
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.76500067
5Shigellosis_Homo sapiens_hsa051312.29504817
6Dilated cardiomyopathy_Homo sapiens_hsa054142.24293189
7Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.19261040
8Other glycan degradation_Homo sapiens_hsa005112.09568037
9Carbon metabolism_Homo sapiens_hsa012002.05908204
10Cardiac muscle contraction_Homo sapiens_hsa042601.93271716
11Salmonella infection_Homo sapiens_hsa051321.92841377
12Fatty acid degradation_Homo sapiens_hsa000711.92655191
13Propanoate metabolism_Homo sapiens_hsa006401.89340671
14Nitrogen metabolism_Homo sapiens_hsa009101.80028076
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.71358876
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.69744123
17Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.68437560
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.62470565
19Proteasome_Homo sapiens_hsa030501.60444204
20Fatty acid metabolism_Homo sapiens_hsa012121.60145676
21Prion diseases_Homo sapiens_hsa050201.59897618
22Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.53509041
23Glucagon signaling pathway_Homo sapiens_hsa049221.52060504
24Biosynthesis of amino acids_Homo sapiens_hsa012301.51642240
25Insulin resistance_Homo sapiens_hsa049311.47821811
26Insulin signaling pathway_Homo sapiens_hsa049101.47656825
27Apoptosis_Homo sapiens_hsa042101.46597102
28Pyruvate metabolism_Homo sapiens_hsa006201.46521646
29mTOR signaling pathway_Homo sapiens_hsa041501.46216649
30Adipocytokine signaling pathway_Homo sapiens_hsa049201.44718480
31Lysosome_Homo sapiens_hsa041421.44667481
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.42744993
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.42579832
34Osteoclast differentiation_Homo sapiens_hsa043801.42422681
35VEGF signaling pathway_Homo sapiens_hsa043701.41918162
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.40662815
37Central carbon metabolism in cancer_Homo sapiens_hsa052301.37234285
38Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.35433064
39Vibrio cholerae infection_Homo sapiens_hsa051101.34221287
40NF-kappa B signaling pathway_Homo sapiens_hsa040641.33698355
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32609598
42Focal adhesion_Homo sapiens_hsa045101.32311896
43Primary immunodeficiency_Homo sapiens_hsa053401.32085545
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.31919833
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.27928607
46Fatty acid biosynthesis_Homo sapiens_hsa000611.27799856
47AMPK signaling pathway_Homo sapiens_hsa041521.25607413
48Pyrimidine metabolism_Homo sapiens_hsa002401.25593008
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.24355300
50Arginine biosynthesis_Homo sapiens_hsa002201.23692218
51Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.22600195
52PPAR signaling pathway_Homo sapiens_hsa033201.22172282
53Ribosome_Homo sapiens_hsa030101.22050443
54Bladder cancer_Homo sapiens_hsa052191.21532735
55Antigen processing and presentation_Homo sapiens_hsa046121.20791803
56Chronic myeloid leukemia_Homo sapiens_hsa052201.20561760
57Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.15975034
58TNF signaling pathway_Homo sapiens_hsa046681.13913288
59Longevity regulating pathway - mammal_Homo sapiens_hsa042111.13512160
60Malaria_Homo sapiens_hsa051441.13392950
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.12301205
62Leishmaniasis_Homo sapiens_hsa051401.10885551
63Viral myocarditis_Homo sapiens_hsa054161.09638829
64Sulfur relay system_Homo sapiens_hsa041221.08630064
65DNA replication_Homo sapiens_hsa030301.08095780
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.06055291
67Base excision repair_Homo sapiens_hsa034101.05443348
68Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.04537612
69Toxoplasmosis_Homo sapiens_hsa051450.99545871
70Glioma_Homo sapiens_hsa052140.99436195
71Measles_Homo sapiens_hsa051620.99238546
72Fructose and mannose metabolism_Homo sapiens_hsa000510.97228214
73Proteoglycans in cancer_Homo sapiens_hsa052050.97225794
74N-Glycan biosynthesis_Homo sapiens_hsa005100.97037490
75Epstein-Barr virus infection_Homo sapiens_hsa051690.96991699
76Galactose metabolism_Homo sapiens_hsa000520.96419393
77HIF-1 signaling pathway_Homo sapiens_hsa040660.95296148
78HTLV-I infection_Homo sapiens_hsa051660.94715923
79Phagosome_Homo sapiens_hsa041450.92732554
80Influenza A_Homo sapiens_hsa051640.92465718
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92420467
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.90855699
83Pertussis_Homo sapiens_hsa051330.90508594
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.90504970
85AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90459844
86Hepatitis B_Homo sapiens_hsa051610.90416706
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.89579549
88Herpes simplex infection_Homo sapiens_hsa051680.89000094
89Acute myeloid leukemia_Homo sapiens_hsa052210.88581255
90Non-small cell lung cancer_Homo sapiens_hsa052230.88020541
91Hematopoietic cell lineage_Homo sapiens_hsa046400.85890717
92Tuberculosis_Homo sapiens_hsa051520.85696848
93Rheumatoid arthritis_Homo sapiens_hsa053230.85176005
94Starch and sucrose metabolism_Homo sapiens_hsa005000.84981757
95Oxytocin signaling pathway_Homo sapiens_hsa049210.83436501
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.83147600
97cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82517816
98Amoebiasis_Homo sapiens_hsa051460.81281781
99Graft-versus-host disease_Homo sapiens_hsa053320.80193566
100Estrogen signaling pathway_Homo sapiens_hsa049150.77061204
101Viral carcinogenesis_Homo sapiens_hsa052030.76999487
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.76867840
103Synaptic vesicle cycle_Homo sapiens_hsa047210.75815718
104Gastric acid secretion_Homo sapiens_hsa049710.75179017
105Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.74156885
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74132883
107Lysine degradation_Homo sapiens_hsa003100.73827721
108Legionellosis_Homo sapiens_hsa051340.72292132
109Hepatitis C_Homo sapiens_hsa051600.72148128
110Pentose phosphate pathway_Homo sapiens_hsa000300.71155759
111Bile secretion_Homo sapiens_hsa049760.71084299
112Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70447970
113ECM-receptor interaction_Homo sapiens_hsa045120.68720928
114GnRH signaling pathway_Homo sapiens_hsa049120.68555099
115Notch signaling pathway_Homo sapiens_hsa043300.67231767
116T cell receptor signaling pathway_Homo sapiens_hsa046600.66467813
117Endometrial cancer_Homo sapiens_hsa052130.66268809
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66084983
119Tight junction_Homo sapiens_hsa045300.65936243
120Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64916051
121Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64733381
122Allograft rejection_Homo sapiens_hsa053300.64079486
123Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63689134
124Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62305648
125Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62188367
126Dorso-ventral axis formation_Homo sapiens_hsa043200.61976258
127Platelet activation_Homo sapiens_hsa046110.61368128
128Adherens junction_Homo sapiens_hsa045200.61161595
129Autoimmune thyroid disease_Homo sapiens_hsa053200.59877021
130Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59393405
131Thyroid cancer_Homo sapiens_hsa052160.59223713
132Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57329020
133Small cell lung cancer_Homo sapiens_hsa052220.56849253
134Leukocyte transendothelial migration_Homo sapiens_hsa046700.56800672
135Type II diabetes mellitus_Homo sapiens_hsa049300.56426663
136Sphingolipid signaling pathway_Homo sapiens_hsa040710.56371170
137Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55810672
138Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55744761
139Spliceosome_Homo sapiens_hsa030400.52299517
140Endocytosis_Homo sapiens_hsa041440.51642188
141Renal cell carcinoma_Homo sapiens_hsa052110.51399299
142Glutathione metabolism_Homo sapiens_hsa004800.51390196
143Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.49201947
144Chemokine signaling pathway_Homo sapiens_hsa040620.48444190
145NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47680584
146Renin secretion_Homo sapiens_hsa049240.47556358
147Gap junction_Homo sapiens_hsa045400.46803866
148Tryptophan metabolism_Homo sapiens_hsa003800.46796759
149Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46451856
150Prolactin signaling pathway_Homo sapiens_hsa049170.46055749
151p53 signaling pathway_Homo sapiens_hsa041150.45810390
152Pancreatic cancer_Homo sapiens_hsa052120.44317430
153Butanoate metabolism_Homo sapiens_hsa006500.44063133
154Fat digestion and absorption_Homo sapiens_hsa049750.43996587
155Vascular smooth muscle contraction_Homo sapiens_hsa042700.43410978
156Glycerolipid metabolism_Homo sapiens_hsa005610.42299488
157Phospholipase D signaling pathway_Homo sapiens_hsa040720.38852278
158Glycosaminoglycan degradation_Homo sapiens_hsa005310.37712959
159Parkinsons disease_Homo sapiens_hsa050120.37368019
160B cell receptor signaling pathway_Homo sapiens_hsa046620.36563943
161Rap1 signaling pathway_Homo sapiens_hsa040150.36025177

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