DR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.78424596
2negative regulation of erythrocyte differentiation (GO:0045647)5.49845788
3regulation of gamma-delta T cell differentiation (GO:0045586)5.08454641
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.07726367
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.07726367
6negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.93140490
7regulation of gamma-delta T cell activation (GO:0046643)4.89483726
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.70464859
9valine metabolic process (GO:0006573)4.60715529
10regulation of DNA endoreduplication (GO:0032875)4.57605021
11positive regulation of natural killer cell differentiation (GO:0032825)4.46565684
12antigen processing and presentation of endogenous antigen (GO:0019883)4.34894212
13attachment of spindle microtubules to kinetochore (GO:0008608)4.26569108
14DNA double-strand break processing (GO:0000729)4.25642798
15positive regulation of B cell differentiation (GO:0045579)4.16615546
16epithelial cell differentiation involved in prostate gland development (GO:0060742)4.14016067
17natural killer cell differentiation (GO:0001779)4.10227748
18B cell mediated immunity (GO:0019724)4.09358533
19regulation of B cell differentiation (GO:0045577)3.73788475
20chromatin remodeling at centromere (GO:0031055)3.73177593
21RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.72628507
22CENP-A containing nucleosome assembly (GO:0034080)3.70510227
23peptidyl-arginine omega-N-methylation (GO:0035247)3.63025154
24Peyers patch development (GO:0048541)3.61326963
25mucosal-associated lymphoid tissue development (GO:0048537)3.61326963
26negative regulation of DNA-dependent DNA replication (GO:2000104)3.60016423
27protein K6-linked ubiquitination (GO:0085020)3.57485016
28positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.56504449
29DNA replication checkpoint (GO:0000076)3.55025330
30Arp2/3 complex-mediated actin nucleation (GO:0034314)3.54011986
31regulation of chromatin silencing (GO:0031935)3.53858845
32DNA deamination (GO:0045006)3.49976027
33peptidyl-arginine methylation (GO:0018216)3.49500326
34peptidyl-arginine N-methylation (GO:0035246)3.49500326
35negative regulation of myeloid cell apoptotic process (GO:0033033)3.46944061
36replicative senescence (GO:0090399)3.46343406
37negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.43907053
38negative regulation of cell killing (GO:0031342)3.43907053
39somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.40670457
40isotype switching (GO:0045190)3.40670457
41somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.40670457
42histone exchange (GO:0043486)3.38118983
43regulation of chemokine biosynthetic process (GO:0045073)3.37716849
44protein K11-linked deubiquitination (GO:0035871)3.36155097
45kinetochore organization (GO:0051383)3.28777345
46nuclear pore complex assembly (GO:0051292)3.28502598
47neural tube formation (GO:0001841)3.27623806
48maturation of 5.8S rRNA (GO:0000460)3.26023311
49rRNA catabolic process (GO:0016075)3.23868109
50double-strand break repair via homologous recombination (GO:0000724)3.22571041
51recombinational repair (GO:0000725)3.21979506
52DNA replication-dependent nucleosome assembly (GO:0006335)3.20932651
53DNA replication-dependent nucleosome organization (GO:0034723)3.20932651
54sister chromatid segregation (GO:0000819)3.18560510
55mitotic sister chromatid segregation (GO:0000070)3.15976661
56cytoplasmic mRNA processing body assembly (GO:0033962)3.14657570
57positive regulation of mitotic sister chromatid separation (GO:1901970)3.14622827
58positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.14622827
59positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.14622827
60microtubule cytoskeleton organization involved in mitosis (GO:1902850)3.13734154
61nuclear pore organization (GO:0006999)3.12273779
62regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.11224273
63regulation of mitotic spindle checkpoint (GO:1903504)3.11224273
64synapsis (GO:0007129)3.08958597
65regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)3.08793753
66translesion synthesis (GO:0019985)3.06873834
67myoblast migration (GO:0051451)3.06620478
68regulation of natural killer cell differentiation (GO:0032823)3.06500953
69regulation of erythrocyte differentiation (GO:0045646)3.04189732
70monoubiquitinated protein deubiquitination (GO:0035520)3.04176640
71somatic recombination of immunoglobulin gene segments (GO:0016447)3.04050532
72regulation of centriole replication (GO:0046599)3.00778298
73mitotic metaphase plate congression (GO:0007080)3.00387928
74positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.99879647
75positive regulation of natural killer cell mediated immunity (GO:0002717)2.99879647
76mitotic sister chromatid cohesion (GO:0007064)2.98255954
77somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.97184326
78somatic cell DNA recombination (GO:0016444)2.97184326
79meiotic chromosome segregation (GO:0045132)2.96391258
80microtubule anchoring (GO:0034453)2.95815184
81spindle checkpoint (GO:0031577)2.94895176
82DNA catabolic process, exonucleolytic (GO:0000738)2.90756738
83exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.90567262
84regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.90403777
85regulation of natural killer cell mediated immunity (GO:0002715)2.90403777
86somatic hypermutation of immunoglobulin genes (GO:0016446)2.88783081
87somatic diversification of immune receptors via somatic mutation (GO:0002566)2.88783081
88modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.88586258
89positive regulation by organism of defense response of other organism involved in symbiotic interact2.88586258
90modulation by symbiont of host immune response (GO:0052553)2.88586258
91positive regulation by symbiont of host defense response (GO:0052509)2.88586258
92modulation by symbiont of host defense response (GO:0052031)2.88586258
93modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.88586258
94regulation of centrosome cycle (GO:0046605)2.88015189
95pentose-phosphate shunt (GO:0006098)2.87890292
96somatic diversification of immunoglobulins (GO:0016445)2.85961815
97somatic diversification of immune receptors (GO:0002200)2.84692436
98JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.83864510
99regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.83676440
100regulation of mitotic metaphase/anaphase transition (GO:0030071)2.83676440
101V(D)J recombination (GO:0033151)2.83415883
102metaphase plate congression (GO:0051310)2.82783477
103spindle assembly involved in mitosis (GO:0090307)2.82709111
104mitotic spindle checkpoint (GO:0071174)2.80088427
105regulation of mitotic sister chromatid separation (GO:0010965)2.79747119
106regulation of mitotic sister chromatid segregation (GO:0033047)2.79747119
107regulation of sister chromatid segregation (GO:0033045)2.79747119
108response to UV-C (GO:0010225)2.77689316
109DNA unwinding involved in DNA replication (GO:0006268)2.77029873
110response to X-ray (GO:0010165)2.76998922
111histone mRNA catabolic process (GO:0071044)2.76643936
112negative regulation of sister chromatid segregation (GO:0033046)2.74825295
113negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.74825295
114negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.74825295
115negative regulation of mitotic sister chromatid segregation (GO:0033048)2.74825295
116negative regulation of mitotic sister chromatid separation (GO:2000816)2.74825295
117histone-serine phosphorylation (GO:0035404)2.74452628
118negative regulation of chromosome segregation (GO:0051985)2.73986805
119mitotic G2/M transition checkpoint (GO:0044818)2.73640868
120nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.72187727
121mitochondrial DNA replication (GO:0006264)2.71985693
122sulfation (GO:0051923)2.71394748
123kinetochore assembly (GO:0051382)2.68363262
124regulation of DNA damage checkpoint (GO:2000001)2.67782190
125DNA-dependent DNA replication (GO:0006261)2.67443822
126DNA replication-independent nucleosome organization (GO:0034724)2.66064489
127DNA replication-independent nucleosome assembly (GO:0006336)2.66064489
128positive regulation of mRNA metabolic process (GO:1903313)2.65934364
129ribosome assembly (GO:0042255)2.65876759
130positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.64439481
131centrosome organization (GO:0051297)2.64020832
132non-recombinational repair (GO:0000726)2.63479723
133double-strand break repair via nonhomologous end joining (GO:0006303)2.63479723
134magnesium ion transport (GO:0015693)2.63383189
135histone mRNA metabolic process (GO:0008334)2.63297114
136regulation of chromosome segregation (GO:0051983)2.63292799
137regulation of centrosome duplication (GO:0010824)2.60939913
138IMP biosynthetic process (GO:0006188)2.60155753
139nuclear envelope disassembly (GO:0051081)2.59444096
140membrane disassembly (GO:0030397)2.59444096
141positive regulation of mRNA processing (GO:0050685)2.58344232
142immunoglobulin mediated immune response (GO:0016064)2.57963789
143protein prenylation (GO:0018342)2.57320040
144prenylation (GO:0097354)2.57320040
145regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.55474697
146histone arginine methylation (GO:0034969)2.54914268
147IMP metabolic process (GO:0046040)2.53840022
148T cell homeostasis (GO:0043029)2.53564777
149actin nucleation (GO:0045010)2.52614607
150regulation of interleukin-12 biosynthetic process (GO:0045075)2.51937879
151folic acid-containing compound biosynthetic process (GO:0009396)2.51890469
152NADPH regeneration (GO:0006740)2.50812800
153cytokinetic process (GO:0032506)2.49423439
154pore complex assembly (GO:0046931)2.48624066
155regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.48424759
156viral transcription (GO:0019083)2.48151676
157negative regulation of RNA splicing (GO:0033119)2.47513774
158translational termination (GO:0006415)2.46440262
1593-UTR-mediated mRNA stabilization (GO:0070935)2.45721096
160regulation of gene silencing (GO:0060968)2.44949973
161leukocyte aggregation (GO:0070486)2.44595495
162positive regulation of natural killer cell activation (GO:0032816)2.44370498
163regulation of B cell receptor signaling pathway (GO:0050855)2.43249876
164antigen processing and presentation via MHC class Ib (GO:0002475)2.41354091
165negative regulation of B cell activation (GO:0050869)2.40598371
166natural killer cell activation (GO:0030101)2.39965537
167positive regulation of erythrocyte differentiation (GO:0045648)2.38320949
168protein localization to kinetochore (GO:0034501)2.36061751
169T cell migration (GO:0072678)2.35955043
170respiratory burst (GO:0045730)2.34406223
171protein localization to chromosome, centromeric region (GO:0071459)2.33179947
172angiogenesis involved in wound healing (GO:0060055)2.32174703
173negative regulation of phagocytosis (GO:0050765)2.31098509
174myeloid dendritic cell activation (GO:0001773)2.30703716
175lymphocyte mediated immunity (GO:0002449)2.29583848
176replication fork processing (GO:0031297)2.29513289
177mannose metabolic process (GO:0006013)2.28753762
178nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.26652320
179response to interferon-alpha (GO:0035455)2.25896786
180regulation of histone H3-K9 methylation (GO:0051570)2.25795307
181positive regulation of macrophage differentiation (GO:0045651)2.25626324
182DNA replication initiation (GO:0006270)2.25228261
183maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.24649164
184mitotic nuclear envelope disassembly (GO:0007077)2.24529365
185positive regulation of interferon-beta production (GO:0032728)2.24087817
186negative regulation of interleukin-12 production (GO:0032695)2.24016613
187myeloid dendritic cell differentiation (GO:0043011)2.22167556
188response to type I interferon (GO:0034340)2.21991140
189type I interferon signaling pathway (GO:0060337)2.21980899

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.93802484
2GATA1_22025678_ChIP-Seq_K562_Human3.78348894
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.35055552
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.30310150
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.23617295
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.95517236
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.88804047
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.87677397
9* EWS_26573619_Chip-Seq_HEK293_Human2.79747506
10MYC_22102868_ChIP-Seq_BL_Human2.74126385
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.68391750
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.68343494
13* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.59959397
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.57579428
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.57466288
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.54447697
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.49033992
18VDR_21846776_ChIP-Seq_THP-1_Human2.46810942
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.37689464
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.35950909
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.35643653
22FUS_26573619_Chip-Seq_HEK293_Human2.28730048
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.24945261
24* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.24225845
25MYC_18555785_ChIP-Seq_MESCs_Mouse2.23523553
26SCL_19346495_ChIP-Seq_HPC-7_Human2.20726803
27ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.20694881
28MYB_26560356_Chip-Seq_TH2_Human2.14870148
29BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.11174005
30IRF8_27001747_Chip-Seq_BMDM_Mouse2.10677785
31* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.04756475
32* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.01452001
33TAF15_26573619_Chip-Seq_HEK293_Human2.00273834
34* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.00232044
35IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.99311519
36SPI1_23547873_ChIP-Seq_NB4_Human1.98386257
37SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.97432818
38BRD4_27068464_Chip-Seq_AML-cells_Mouse1.96341671
39* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.94558509
40ZNF274_21170338_ChIP-Seq_K562_Hela1.91763049
41STAT4_19710469_ChIP-ChIP_TH1__Mouse1.86813062
42MYC_18940864_ChIP-ChIP_HL60_Human1.86076211
43MYB_26560356_Chip-Seq_TH1_Human1.84359764
44BP1_19119308_ChIP-ChIP_Hs578T_Human1.83939361
45TCF7_22412390_ChIP-Seq_EML_Mouse1.81215769
46PADI4_21655091_ChIP-ChIP_MCF-7_Human1.80935411
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.80055132
48AR_21909140_ChIP-Seq_LNCAP_Human1.78559613
49* MAF_26560356_Chip-Seq_TH1_Human1.76967060
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.73141259
51MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.72764615
52VDR_22108803_ChIP-Seq_LS180_Human1.72644664
53FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.71248096
54HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.71042073
55FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.69586466
56RUNX1_22412390_ChIP-Seq_EML_Mouse1.69198997
57RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.68577360
58STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.66173985
59ELF1_17652178_ChIP-ChIP_JURKAT_Human1.65231153
60IGF1R_20145208_ChIP-Seq_DFB_Human1.62469487
61UTX_26944678_Chip-Seq_JUKART_Human1.61869917
62TP63_19390658_ChIP-ChIP_HaCaT_Human1.58992463
63E2F1_21310950_ChIP-Seq_MCF-7_Human1.58530850
64RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56336762
65VDR_24763502_ChIP-Seq_THP-1_Human1.56084040
66P300_19829295_ChIP-Seq_ESCs_Human1.53277692
67NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.52325535
68MYC_19079543_ChIP-ChIP_MESCs_Mouse1.47956775
69POU5F1_16153702_ChIP-ChIP_HESCs_Human1.47715417
70* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.45843894
71* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.44703355
72CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.41405696
73RUNX_20019798_ChIP-Seq_JUKART_Human1.38636040
74PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38453935
75AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.37817145
76SMAD_19615063_ChIP-ChIP_OVARY_Human1.36106700
77* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.35488646
78KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.35125119
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34879619
80EZH2_27294783_Chip-Seq_NPCs_Mouse1.32683198
81TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.32579632
82MYC_18358816_ChIP-ChIP_MESCs_Mouse1.31417583
83RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.31229775
84* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.30020350
85VDR_23849224_ChIP-Seq_CD4+_Human1.29987147
86SPI1_23127762_ChIP-Seq_K562_Human1.28508954
87GBX2_23144817_ChIP-Seq_PC3_Human1.27686476
88* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.26854749
89GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.26854685
90FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.25880093
91PU_27001747_Chip-Seq_BMDM_Mouse1.25080939
92GATA2_22383799_ChIP-Seq_G1ME_Mouse1.24905945
93HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.24347622
94GATA3_27048872_Chip-Seq_THYMUS_Human1.23215984
95* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.23201867
96* XRN2_22483619_ChIP-Seq_HELA_Human1.20490583
97SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19810837
98IRF1_19129219_ChIP-ChIP_H3396_Human1.19297174
99HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19241367
100ER_23166858_ChIP-Seq_MCF-7_Human1.19041776
101ELK1_19687146_ChIP-ChIP_HELA_Human1.18431154
102* ELK3_25401928_ChIP-Seq_HUVEC_Human1.18061079
103MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.17393894
104* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.17358520
105TFEB_21752829_ChIP-Seq_HELA_Human1.17308726
106* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17194655
107MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16274340
108MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15488027
109* MAF_26560356_Chip-Seq_TH2_Human1.13986987
110PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13781758
111NOTCH1_21737748_ChIP-Seq_TLL_Human1.13250067
112RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.12979933
113EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12562038
114CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12117853
115YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11905319
116CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11902306
117NFE2_27457419_Chip-Seq_LIVER_Mouse1.11554125
118GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07276000
119CREB1_15753290_ChIP-ChIP_HEK293T_Human1.07210523
120* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06667377
121PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05174083
122* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.04513819
123FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04359689
124KDM5A_27292631_Chip-Seq_BREAST_Human1.03636409
125KDM2B_26808549_Chip-Seq_DND41_Human1.03370217
126OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03298326
127UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03244418
128IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03231482
129CBP_20019798_ChIP-Seq_JUKART_Human1.03231482
130ZFX_18555785_ChIP-Seq_MESCs_Mouse1.03028912
131CRX_20693478_ChIP-Seq_RETINA_Mouse1.01686143
132NANOG_16153702_ChIP-ChIP_HESCs_Human1.01147027
133* NCOR1_26117541_ChIP-Seq_K562_Human1.00803472
134STAT3_1855785_ChIP-Seq_MESCs_Mouse1.00580837
135ETS1_22383799_ChIP-Seq_G1ME_Mouse1.00407823
136RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.99623779
137STAT3_23295773_ChIP-Seq_U87_Human0.97346610
138SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.97014197
139Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.96831215
140* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.96710618
141FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.96426070
142SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.95038159
143NANOG_18555785_Chip-Seq_ESCs_Mouse0.94856824
144ZNF263_19887448_ChIP-Seq_K562_Human0.94803350
145* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.94175329
146CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93856418
147TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93359724
148MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.92163061
149CIITA_25753668_ChIP-Seq_RAJI_Human0.91875458
150FLI1_21867929_ChIP-Seq_TH2_Mouse0.90138899
151PCGF2_27294783_Chip-Seq_NPCs_Mouse0.90050987
152MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.89180046
153SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88889733
154OCT4_21477851_ChIP-Seq_ESCs_Mouse0.88602038
155CDX2_22108803_ChIP-Seq_LS180_Human0.88276798
156P53_22387025_ChIP-Seq_ESCs_Mouse0.88247129
157TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87866080
158* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.87742534
159E2F1_18555785_Chip-Seq_ESCs_Mouse0.86996573
160ETS1_20019798_ChIP-Seq_JURKAT_Human0.86919849
161CTBP1_25329375_ChIP-Seq_LNCAP_Human0.86576079
162FOXM1_26456572_ChIP-Seq_MCF-7_Human0.86343068
163FOXP3_21729870_ChIP-Seq_TREG_Human0.85213246
164* GATA3_26560356_Chip-Seq_TH2_Human0.85044639
165* GABP_17652178_ChIP-ChIP_JURKAT_Human0.84869767
166NANOG_19829295_ChIP-Seq_ESCs_Human0.84843233
167SOX2_19829295_ChIP-Seq_ESCs_Human0.84843233
168DCP1A_22483619_ChIP-Seq_HELA_Human0.84804816
169SMAD4_21799915_ChIP-Seq_A2780_Human0.84417443
170* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.84224551
171JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.84078385
172TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.81489538

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation2.89898800
2MP0003303_peritoneal_inflammation2.72583327
3MP0000569_abnormal_digit_pigmentation2.58581065
4MP0003436_decreased_susceptibility_to2.56726431
5MP0002102_abnormal_ear_morphology2.52893741
6MP0002396_abnormal_hematopoietic_system2.52592745
7MP0009697_abnormal_copulation2.46472706
8MP0009333_abnormal_splenocyte_physiolog2.38235901
9MP0010352_gastrointestinal_tract_polyps2.34631784
10MP0000685_abnormal_immune_system2.25069894
11MP0009785_altered_susceptibility_to2.22812503
12MP0002166_altered_tumor_susceptibility2.20446786
13MP0005000_abnormal_immune_tolerance2.18728826
14MP0005025_abnormal_response_to2.13551207
15MP0004808_abnormal_hematopoietic_stem2.09109448
16MP0001800_abnormal_humoral_immune2.08525249
17MP0002452_abnormal_antigen_presenting2.06740903
18MP0001545_abnormal_hematopoietic_system2.05018890
19MP0005397_hematopoietic_system_phenotyp2.05018890
20MP0002398_abnormal_bone_marrow2.03991370
21MP0010307_abnormal_tumor_latency2.03788774
22MP0006082_CNS_inflammation2.03321016
23MP0003693_abnormal_embryo_hatching2.00599814
24MP0002160_abnormal_reproductive_system2.00008290
25MP0003786_premature_aging1.99101197
26MP0005671_abnormal_response_to1.98945035
27MP0002723_abnormal_immune_serum1.97346761
28MP0001819_abnormal_immune_cell1.94337205
29MP0000372_irregular_coat_pigmentation1.92637672
30MP0006292_abnormal_olfactory_placode1.92466977
31MP0002006_tumorigenesis1.92131630
32MP0002420_abnormal_adaptive_immunity1.91027244
33MP0003890_abnormal_embryonic-extraembry1.89783579
34MP0002419_abnormal_innate_immunity1.89325100
35MP0003300_gastrointestinal_ulcer1.88074810
36MP0002405_respiratory_system_inflammati1.87634965
37MP0010094_abnormal_chromosome_stability1.85017052
38MP0010155_abnormal_intestine_physiology1.83143949
39MP0001853_heart_inflammation1.81782213
40MP0005464_abnormal_platelet_physiology1.81767285
41MP0003763_abnormal_thymus_physiology1.79701477
42MP0002148_abnormal_hypersensitivity_rea1.77931840
43MP0003718_maternal_effect1.77452205
44MP0004185_abnormal_adipocyte_glucose1.77212512
45MP0002254_reproductive_system_inflammat1.75161379
46MP0005387_immune_system_phenotype1.73767159
47MP0001790_abnormal_immune_system1.73767159
48MP0000689_abnormal_spleen_morphology1.69453006
49MP0002722_abnormal_immune_system1.69379445
50MP0000716_abnormal_immune_system1.69150908
51MP0006054_spinal_hemorrhage1.63515446
52MP0003077_abnormal_cell_cycle1.62638288
53MP0005076_abnormal_cell_differentiation1.62453584
54MP0004957_abnormal_blastocyst_morpholog1.62333665
55MP0000703_abnormal_thymus_morphology1.62082268
56MP0005174_abnormal_tail_pigmentation1.61707970
57MP0001845_abnormal_inflammatory_respons1.59556040
58MP0004134_abnormal_chest_morphology1.57467153
59MP0000465_gastrointestinal_hemorrhage1.57449334
60MP0003937_abnormal_limbs/digits/tail_de1.56217327
61MP0002429_abnormal_blood_cell1.56021025
62MP0010234_abnormal_vibrissa_follicle1.55240904
63MP0009278_abnormal_bone_marrow1.54998330
64MP0000490_abnormal_crypts_of1.53637617
65MP0004947_skin_inflammation1.52887391
66MP0005389_reproductive_system_phenotype1.51504370
67MP0008932_abnormal_embryonic_tissue1.50825903
68MP0005075_abnormal_melanosome_morpholog1.48436298
69MP0003646_muscle_fatigue1.47963591
70MP0005187_abnormal_penis_morphology1.47340974
71MP0002019_abnormal_tumor_incidence1.44037580
72MP0008057_abnormal_DNA_replication1.43400658
73MP0003724_increased_susceptibility_to1.42482616
74MP0003448_altered_tumor_morphology1.42267592
75MP0003111_abnormal_nucleus_morphology1.37894812
76MP0000015_abnormal_ear_pigmentation1.29794731
77MP0004510_myositis1.27615533
78MP0003566_abnormal_cell_adhesion1.25830120
79MP0001485_abnormal_pinna_reflex1.24715424
80MP0002877_abnormal_melanocyte_morpholog1.22153269
81MP0000427_abnormal_hair_cycle1.22026888
82MP0001533_abnormal_skeleton_physiology1.21571702
83MP0008007_abnormal_cellular_replicative1.21273045
84MP0000350_abnormal_cell_proliferation1.21269544
85MP0001730_embryonic_growth_arrest1.17306117
86MP0000631_abnormal_neuroendocrine_gland1.15865463
87MP0005367_renal/urinary_system_phenotyp1.13060961
88MP0000516_abnormal_urinary_system1.13060961
89MP0002163_abnormal_gland_morphology1.12920632
90MP0006072_abnormal_retinal_apoptosis1.10570286
91MP0008469_abnormal_protein_level1.10552561
92MP0006035_abnormal_mitochondrial_morpho1.10283115
93MP0001873_stomach_inflammation1.08034325
94MP0005310_abnormal_salivary_gland1.07829646
95MP0003195_calcinosis1.06983791
96MP0001915_intracranial_hemorrhage1.06009790
97MP0001188_hyperpigmentation1.04373182
98MP0003119_abnormal_digestive_system1.02017069
99MP0002009_preneoplasia0.99966102
100MP0004381_abnormal_hair_follicle0.99698600
101MP0008058_abnormal_DNA_repair0.99646460
102MP0008995_early_reproductive_senescence0.98985463
103MP0001293_anophthalmia0.98115288
104MP0001286_abnormal_eye_development0.97250049
105MP0003705_abnormal_hypodermis_morpholog0.96458395
106MP0002751_abnormal_autonomic_nervous0.95588663
107MP0000313_abnormal_cell_death0.95543053
108MP0001119_abnormal_female_reproductive0.95175893
109MP0002084_abnormal_developmental_patter0.94134969
110MP0000858_altered_metastatic_potential0.93424247
111MP0002086_abnormal_extraembryonic_tissu0.92325641
112MP0004145_abnormal_muscle_electrophysio0.92268430
113MP0001849_ear_inflammation0.90719392
114MP0003656_abnormal_erythrocyte_physiolo0.90192011
115MP0005023_abnormal_wound_healing0.89773266
116MP0002933_joint_inflammation0.89392153
117MP0001697_abnormal_embryo_size0.88668481
118MP0009764_decreased_sensitivity_to0.87949909
119MP0001661_extended_life_span0.87448183
120MP0000733_abnormal_muscle_development0.87141041
121MP0001919_abnormal_reproductive_system0.87027355
122MP0001881_abnormal_mammary_gland0.86435775
123MP0005646_abnormal_pituitary_gland0.86087904
124MP0003866_abnormal_defecation0.85639774
125MP0000343_altered_response_to0.85229163
126MP0004215_abnormal_myocardial_fiber0.85218008
127MP0000653_abnormal_sex_gland0.83597407
128MP0008877_abnormal_DNA_methylation0.83499193
129MP0004197_abnormal_fetal_growth/weight/0.83044312
130MP0005253_abnormal_eye_physiology0.81308928
131MP0002095_abnormal_skin_pigmentation0.80645767
132MP0001929_abnormal_gametogenesis0.79770637
133MP0001851_eye_inflammation0.78860703
134MP0002085_abnormal_embryonic_tissue0.78131399
135MP0001145_abnormal_male_reproductive0.77842554
136MP0003787_abnormal_imprinting0.77610477
137MP0009250_abnormal_appendicular_skeleto0.76400381
138MP0000358_abnormal_cell_content/0.76379200
139MP0002080_prenatal_lethality0.75698797
140MP0004130_abnormal_muscle_cell0.75308169
141MP0003950_abnormal_plasma_membrane0.74159285
142MP0008872_abnormal_physiological_respon0.73948601
143MP0002938_white_spotting0.73745007
144MP0002210_abnormal_sex_determination0.73703979
145MP0006036_abnormal_mitochondrial_physio0.73526653
146MP0005166_decreased_susceptibility_to0.73427975
147MP0002928_abnormal_bile_duct0.72190549
148MP0002090_abnormal_vision0.71074688
149MP0002088_abnormal_embryonic_growth/wei0.70870581
150MP0005084_abnormal_gallbladder_morpholo0.70423404
151MP0010678_abnormal_skin_adnexa0.70252796
152MP0005167_abnormal_blood-brain_barrier0.70155944
153MP0000647_abnormal_sebaceous_gland0.69742418
154MP0009053_abnormal_anal_canal0.69035661
155MP0002138_abnormal_hepatobiliary_system0.69013332
156MP0003828_pulmonary_edema0.68367201
157MP0009931_abnormal_skin_appearance0.68102333
158MP0008961_abnormal_basal_metabolism0.68028439
159MP0000049_abnormal_middle_ear0.67684706
160MP0005666_abnormal_adipose_tissue0.67520584
161MP0005621_abnormal_cell_physiology0.67502706
162MP0005083_abnormal_biliary_tract0.67264464
163MP0003795_abnormal_bone_structure0.66895761
164MP0003984_embryonic_growth_retardation0.66620728
165MP0005380_embryogenesis_phenotype0.66474881
166MP0001672_abnormal_embryogenesis/_devel0.66474881

Predicted human phenotypes

RankGene SetZ-score
1Nasal polyposis (HP:0100582)4.34383974
2Recurrent abscess formation (HP:0002722)4.32521209
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.16554261
4Abnormality of chromosome stability (HP:0003220)3.99599761
5Eczematoid dermatitis (HP:0000976)3.94083824
6Abnormality of the nasal mucosa (HP:0000433)3.85249621
7Chronic otitis media (HP:0000389)3.77640947
8Recurrent bacterial skin infections (HP:0005406)3.75245414
9Chromsome breakage (HP:0040012)3.71630041
10Thrombocytosis (HP:0001894)3.70470190
11Myositis (HP:0100614)3.59552372
12Recurrent bronchitis (HP:0002837)3.46459153
13Aplasia/Hypoplasia of the uvula (HP:0010293)3.41126774
14Petechiae (HP:0000967)3.25968619
15IgM deficiency (HP:0002850)3.25420720
16Meckel diverticulum (HP:0002245)3.18195838
17Amaurosis fugax (HP:0100576)3.07170536
18Ectopic kidney (HP:0000086)3.06021161
19Abnormality of the ileum (HP:0001549)3.03286605
20Abnormality of the preputium (HP:0100587)3.01418679
21Pancreatic cysts (HP:0001737)3.01057874
22Pustule (HP:0200039)2.96267021
23Meningioma (HP:0002858)2.93247263
24Disinhibition (HP:0000734)2.89712623
25Mediastinal lymphadenopathy (HP:0100721)2.89577841
26Recurrent viral infections (HP:0004429)2.83605886
27Agnosia (HP:0010524)2.82685300
28Cellulitis (HP:0100658)2.79127357
29Severe combined immunodeficiency (HP:0004430)2.77657742
30Duodenal stenosis (HP:0100867)2.76176803
31Small intestinal stenosis (HP:0012848)2.76176803
32Abnormality of the renal collecting system (HP:0004742)2.75290129
33Elevated erythrocyte sedimentation rate (HP:0003565)2.73888560
34Abnormality of B cell number (HP:0010975)2.72377418
35Abnormality of DNA repair (HP:0003254)2.70155583
36Orchitis (HP:0100796)2.67287720
37Hypercortisolism (HP:0001578)2.65438432
38T lymphocytopenia (HP:0005403)2.63978233
39Clubbing of toes (HP:0100760)2.61714726
40Chest pain (HP:0100749)2.60000419
41B lymphocytopenia (HP:0010976)2.59701733
42Obstructive lung disease (HP:0006536)2.58641210
43Chronic obstructive pulmonary disease (HP:0006510)2.58641210
44Abnormality of T cell number (HP:0011839)2.57355456
45Short 1st metacarpal (HP:0010034)2.56961812
46Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.56961812
47Duplicated collecting system (HP:0000081)2.55907960
48Genetic anticipation (HP:0003743)2.55581728
49Carpal bone hypoplasia (HP:0001498)2.55216874
50Abnormality of cells of the erythroid lineage (HP:0012130)2.54220289
51Progressive inability to walk (HP:0002505)2.53700603
52Pili torti (HP:0003777)2.52899358
53Subacute progressive viral hepatitis (HP:0006572)2.51929650
54Pancreatic fibrosis (HP:0100732)2.51276934
55Small hand (HP:0200055)2.50824390
56Myelodysplasia (HP:0002863)2.50091043
57Sloping forehead (HP:0000340)2.49398829
58Urethral obstruction (HP:0000796)2.47928702
59Absent thumb (HP:0009777)2.47574326
60Abnormality of macrophages (HP:0004311)2.47394696
61Basal cell carcinoma (HP:0002671)2.46821954
62Recurrent fungal infections (HP:0002841)2.45920405
63Interstitial pulmonary disease (HP:0006530)2.45752368
64Retrobulbar optic neuritis (HP:0100654)2.44982768
65Optic neuritis (HP:0100653)2.44982768
66Combined immunodeficiency (HP:0005387)2.43286845
67Pendular nystagmus (HP:0012043)2.42365030
68Conjunctival hamartoma (HP:0100780)2.40280306
69Recurrent gram-negative bacterial infections (HP:0005420)2.39736094
70Truncal obesity (HP:0001956)2.37714178
71Abnormality of T cells (HP:0002843)2.37429546
72Gastrointestinal infarctions (HP:0005244)2.35009956
73Abnormality of the duodenum (HP:0002246)2.33972730
74Volvulus (HP:0002580)2.31207714
75Arterial thrombosis (HP:0004420)2.30993140
76Abnormality of homocysteine metabolism (HP:0010919)2.27839364
77Homocystinuria (HP:0002156)2.27839364
78Vasculitis (HP:0002633)2.26165339
79Abnormal hair laboratory examination (HP:0003328)2.24672488
80Bronchitis (HP:0012387)2.23502394
81Recurrent skin infections (HP:0001581)2.23411135
82Stenosis of the external auditory canal (HP:0000402)2.22004445
83Abnormality of the carotid arteries (HP:0005344)2.21840680
84Acute myeloid leukemia (HP:0004808)2.21121981
85Abnormal number of erythroid precursors (HP:0012131)2.19490620
86Autoimmune thrombocytopenia (HP:0001973)2.15910922
87Abnormality of the pons (HP:0007361)2.15257042
88Abnormality of the 1st metacarpal (HP:0010009)2.14894805
89Colon cancer (HP:0003003)2.14183284
90Methylmalonic acidemia (HP:0002912)2.14023403
91Meningitis (HP:0001287)2.13572751
92Chorioretinal atrophy (HP:0000533)2.12014746
93Abnormality of T cell physiology (HP:0011840)2.10435758
94Neoplasm of the small intestine (HP:0100833)2.09879042
95Absent radius (HP:0003974)2.09410732
96Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.09382886
97True hermaphroditism (HP:0010459)2.09274589
98Cervical subluxation (HP:0003308)2.08336604
99Panhypogammaglobulinemia (HP:0003139)2.08098993
100Spontaneous hematomas (HP:0007420)2.07898298
101Furrowed tongue (HP:0000221)2.07090143
102Aplasia involving forearm bones (HP:0009822)2.06165855
103Absent forearm bone (HP:0003953)2.06165855
104Congenital stationary night blindness (HP:0007642)2.04065332
105Cutaneous melanoma (HP:0012056)2.04058471
106Skin ulcer (HP:0200042)2.02931916
107Increased cerebral lipofuscin (HP:0011813)2.02366853
108IgA deficiency (HP:0002720)2.02287472
109Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.01207671
110Abnormality of the renal cortex (HP:0011035)2.00924581
111Hypoplasia of the pons (HP:0012110)2.00587407
112Stomatitis (HP:0010280)2.00008443
113Absent rod-and cone-mediated responses on ERG (HP:0007688)1.99538544
114Gingivitis (HP:0000230)1.99190460
115Thyroiditis (HP:0100646)1.99034927
116Increased serum ferritin (HP:0003281)1.98573230
117Neoplasm of the adrenal cortex (HP:0100641)1.98558807
118Renal cortical cysts (HP:0000803)1.98115378
119Abolished electroretinogram (ERG) (HP:0000550)1.95754434
120Hematochezia (HP:0002573)1.95387415
121Hamartoma of the eye (HP:0010568)1.95240656
122Periodontitis (HP:0000704)1.93704413
123Abnormal platelet function (HP:0011869)1.93547366
124Impaired platelet aggregation (HP:0003540)1.93547366
125IgG deficiency (HP:0004315)1.93057393
126Hemoptysis (HP:0002105)1.92266440
127Absent frontal sinuses (HP:0002688)1.91398577
128Abnormal platelet volume (HP:0011876)1.91174072
129Birth length less than 3rd percentile (HP:0003561)1.91130023
130Abnormality of iron homeostasis (HP:0011031)1.90736809
131Nephroblastoma (Wilms tumor) (HP:0002667)1.89315375
132Arteriovenous malformation (HP:0100026)1.88866830
133Short hallux (HP:0010109)1.88720628
134Reduced subcutaneous adipose tissue (HP:0003758)1.88703813
135Neoplasm of the oral cavity (HP:0100649)1.88701019
136Prostate neoplasm (HP:0100787)1.88455130
137Viral hepatitis (HP:0006562)1.87551809
138Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.87321602
139Abnormality of alanine metabolism (HP:0010916)1.87321602
140Hyperalaninemia (HP:0003348)1.87321602
141High pitched voice (HP:0001620)1.85308871
142Short thumb (HP:0009778)1.85139690
143Triphalangeal thumb (HP:0001199)1.84859817
144Abnormality of the phalanges of the 5th finger (HP:0004213)1.84314288
145Abnormality of methionine metabolism (HP:0010901)1.83978704
146Aplasia/Hypoplasia of the hallux (HP:0008362)1.82777903
147Ragged-red muscle fibers (HP:0003200)1.82158647
148Pulmonary infiltrates (HP:0002113)1.82138616
149Ependymoma (HP:0002888)1.82034797
150Gastrointestinal inflammation (HP:0004386)1.81800459
151Long nose (HP:0003189)1.81708629
152Increased neuronal autofluorescent lipopigment (HP:0002074)1.81355616
153Autoimmune hemolytic anemia (HP:0001890)1.80962366
154Embryonal renal neoplasm (HP:0011794)1.80010292
155Abnormal delayed hypersensitivity skin test (HP:0002963)1.79276319
156Abnormality of transition element cation homeostasis (HP:0011030)1.79185671
157Abnormality of the prostate (HP:0008775)1.78660985
158Cafe-au-lait spot (HP:0000957)1.78647198
159Abnormal lung lobation (HP:0002101)1.78630572
160Epistaxis (HP:0000421)1.78388673
161Abnormality of the lumbar spine (HP:0100712)1.78366154
162Chronic sinusitis (HP:0011109)1.77219710
163Abnormal auditory evoked potentials (HP:0006958)1.76746108
164Teleangiectasia of the skin (HP:0100585)1.76530077
165Aplasia/Hypoplasia of the tibia (HP:0005772)1.75976024
166Reticulocytopenia (HP:0001896)1.75925113
167Short 5th finger (HP:0009237)1.75910346
168Prolonged bleeding time (HP:0003010)1.75855937
169Hypoplasia of the thymus (HP:0000778)1.75627146
170Benign neoplasm of the central nervous system (HP:0100835)1.75278183
171Conjunctival telangiectasia (HP:0000524)1.75225976
172Abnormality of the vasculature of the conjunctiva (HP:0008054)1.74970307
173Gaze-evoked nystagmus (HP:0000640)1.74486622
174Fair hair (HP:0002286)1.74453646
175Curly hair (HP:0002212)1.74128388
176Inability to walk (HP:0002540)1.73854048
177Tinnitus (HP:0000360)1.73577823
178Amyotrophic lateral sclerosis (HP:0007354)1.73496724
179Basal ganglia calcification (HP:0002135)1.73055188
180Keratoconjunctivitis sicca (HP:0001097)1.72876348
181Hypoplasia of the fovea (HP:0007750)1.71700440
182Aplasia/Hypoplasia of the fovea (HP:0008060)1.71700440
183Keratoconus (HP:0000563)1.70786864
184Increased corneal curvature (HP:0100692)1.70786864
185Inflammation of the large intestine (HP:0002037)1.70553354
186Increased IgE level (HP:0003212)1.70430518
187Fatigue (HP:0012378)1.69888029
188Asplenia (HP:0001746)1.69856520
189Horseshoe kidney (HP:0000085)1.68360460
190Abnormality of aspartate family amino acid metabolism (HP:0010899)1.67394564
191Bone marrow hypocellularity (HP:0005528)1.66770620

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.47052910
2JAK33.93595374
3NME23.58788441
4EIF2AK33.50983022
5TRIM283.06197749
6MAP4K12.97323248
7BUB12.84490342
8BTK2.53866349
9BMPR1B2.44209070
10EEF2K2.37072037
11ACVR1B2.29217269
12FLT32.25226310
13ERBB32.16552754
14BRD42.12796736
15TAF12.08376648
16MAP3K102.06080723
17TYK22.01934379
18KIT1.98536751
19WEE11.94732352
20SCYL21.93222283
21NEK21.86260363
22ZAK1.82857285
23MST1R1.81315673
24CDC71.80545632
25PLK41.79978863
26SYK1.79592621
27PLK31.77290595
28PIM11.69337314
29CSF1R1.67764142
30PKN21.58419645
31NEK11.51971854
32SRPK11.44055191
33MARK31.43864778
34TLK11.42677141
35STK101.42573872
36TGFBR11.41184421
37RPS6KA41.41037955
38TTK1.40375076
39PBK1.39942075
40TEC1.38564544
41SIK31.37635538
42ZAP701.35642567
43TNIK1.35166844
44PASK1.34951305
45GRK11.32647561
46DYRK31.30102552
47TESK11.26798078
48BRSK21.25827968
49CDK121.23811823
50TRIB31.23097258
51PDK41.22823454
52PDK31.22823454
53JAK21.22708786
54MAP3K81.21973096
55VRK11.18967839
56WNK31.17520988
57TBK11.14519182
58RIPK41.13977051
59LRRK21.13176634
60EIF2AK21.13053862
61PLK21.11570153
62LCK1.07956755
63JAK11.05549621
64ITK1.05146846
65CDK41.04921755
66CDK61.04384686
67ADRBK21.04302366
68EIF2AK11.04173141
69TXK1.03045610
70ERN11.02447336
71BMX1.01736607
72LYN1.01512244
73MKNK11.01353318
74STK241.00140735
75PDK10.98582361
76HCK0.98160192
77NLK0.97083643
78PTK60.96838663
79BCR0.96589445
80MAP3K50.94690490
81CSK0.94575847
82RAF10.94051625
83IRAK40.93231420
84MAP3K140.91840134
85VRK20.91798960
86STK30.89894711
87RPS6KB20.88578764
88GRK60.88508037
89TSSK60.87280452
90IKBKB0.84655951
91MAP2K30.83213162
92FES0.82010035
93NEK90.81969360
94STK390.81706194
95MAP4K20.79810419
96TESK20.79640874
97BRSK10.78228440
98TAOK30.78119137
99LATS10.77600968
100ALK0.77548374
101PIK3CG0.76999222
102STK38L0.73104156
103AKT30.71788175
104CSNK1A1L0.71697478
105MELK0.70721795
106PIM20.68500570
107ATM0.67358610
108MAP3K110.67132662
109PDK20.66630213
110BMPR20.66579219
111MKNK20.65354209
112MET0.64829682
113CCNB10.64269679
114TAOK10.63731917
115PAK10.63363429
116OXSR10.62969851
117RPS6KA10.62113273
118ABL10.62107601
119CHEK20.61952252
120KSR10.61791122
121CSNK1G30.61540140
122KDR0.61057126
123MAPK40.60081871
124CSNK1G20.58978704
125TGFBR20.58976735
126PDPK10.58382379
127PNCK0.57094504
128MAP3K40.55463560
129CSNK1G10.54812520
130DYRK1B0.54766065
131RPS6KB10.54115774
132CHEK10.53320197
133MST40.53036106
134PINK10.52117824
135HIPK20.51647634
136AURKB0.51415196
137ERBB40.50373720
138NUAK10.50085679
139CHUK0.49811486
140ATR0.49757030
141STK40.49540626
142IKBKE0.48757274
143KSR20.47142674
144PAK40.46722018
145FGFR30.46625924
146ADRBK10.45666792
147PLK10.45276965
148EGFR0.44448863
149YES10.42089430
150CDK90.41209116
151CDK70.38544296
152INSRR0.37680456
153CAMKK20.36000663
154CDK30.33490544
155PTK2B0.32720291
156RPS6KA50.32376605
157MAP2K10.27915858
158CSNK2A10.27706368
159PAK30.26010778
160MAPK130.25653885
161MAP2K70.24902086
162MAPKAPK50.24401186
163TRPM70.24178092

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.43442677
2Antigen processing and presentation_Homo sapiens_hsa046122.32696498
3DNA replication_Homo sapiens_hsa030302.25617371
4Protein export_Homo sapiens_hsa030602.14401905
5Measles_Homo sapiens_hsa051622.00662799
6B cell receptor signaling pathway_Homo sapiens_hsa046622.00071550
7NF-kappa B signaling pathway_Homo sapiens_hsa040641.96519782
8Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.91810448
9Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.91436840
10Legionellosis_Homo sapiens_hsa051341.89547953
11Primary immunodeficiency_Homo sapiens_hsa053401.81647866
12Osteoclast differentiation_Homo sapiens_hsa043801.81098452
13Herpes simplex infection_Homo sapiens_hsa051681.80569836
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.70077829
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.66551139
16Shigellosis_Homo sapiens_hsa051311.61805874
17Cell cycle_Homo sapiens_hsa041101.56501724
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.55734295
19Spliceosome_Homo sapiens_hsa030401.55538803
20Hepatitis B_Homo sapiens_hsa051611.54506394
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.53488625
22Chronic myeloid leukemia_Homo sapiens_hsa052201.47453182
23Nitrogen metabolism_Homo sapiens_hsa009101.46421625
24p53 signaling pathway_Homo sapiens_hsa041151.45952426
25Mismatch repair_Homo sapiens_hsa034301.45363236
26Acute myeloid leukemia_Homo sapiens_hsa052211.44607185
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.41511767
28Toxoplasmosis_Homo sapiens_hsa051451.41336720
29RNA transport_Homo sapiens_hsa030131.40339624
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.39332942
31Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.38884325
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.38781287
33Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.38294385
34Sulfur metabolism_Homo sapiens_hsa009201.38148705
35Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.37588550
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.37443614
37Tuberculosis_Homo sapiens_hsa051521.36747265
38Viral carcinogenesis_Homo sapiens_hsa052031.33746712
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.32131450
40Ribosome_Homo sapiens_hsa030101.32072031
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.31686479
42Jak-STAT signaling pathway_Homo sapiens_hsa046301.31422371
43T cell receptor signaling pathway_Homo sapiens_hsa046601.30119107
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.28654059
45Allograft rejection_Homo sapiens_hsa053301.28321595
46Apoptosis_Homo sapiens_hsa042101.27560310
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.27085840
48Pertussis_Homo sapiens_hsa051331.25595846
49Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.20632546
50Graft-versus-host disease_Homo sapiens_hsa053321.20341855
51Influenza A_Homo sapiens_hsa051641.20292882
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.18938927
53Malaria_Homo sapiens_hsa051441.18549339
54Glycosaminoglycan degradation_Homo sapiens_hsa005311.18138411
55TNF signaling pathway_Homo sapiens_hsa046681.17502705
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.17487210
57Hematopoietic cell lineage_Homo sapiens_hsa046401.16640141
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.16066118
59Intestinal immune network for IgA production_Homo sapiens_hsa046721.14439327
60Epstein-Barr virus infection_Homo sapiens_hsa051691.12230986
61Small cell lung cancer_Homo sapiens_hsa052221.08193029
62Other glycan degradation_Homo sapiens_hsa005111.07065078
63Melanoma_Homo sapiens_hsa052181.07036049
64Viral myocarditis_Homo sapiens_hsa054161.05946527
65Transcriptional misregulation in cancer_Homo sapiens_hsa052021.05424715
66Alcoholism_Homo sapiens_hsa050341.03182095
67Phototransduction_Homo sapiens_hsa047441.02040806
68Non-small cell lung cancer_Homo sapiens_hsa052231.01291749
69Salmonella infection_Homo sapiens_hsa051321.00122935
70Purine metabolism_Homo sapiens_hsa002300.99482908
71HTLV-I infection_Homo sapiens_hsa051660.98941412
72Base excision repair_Homo sapiens_hsa034100.98182002
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.97952603
74Platelet activation_Homo sapiens_hsa046110.95289620
75MicroRNAs in cancer_Homo sapiens_hsa052060.94342955
76VEGF signaling pathway_Homo sapiens_hsa043700.93670160
77TGF-beta signaling pathway_Homo sapiens_hsa043500.93000532
78Proteasome_Homo sapiens_hsa030500.89993253
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.87402705
80mTOR signaling pathway_Homo sapiens_hsa041500.85075604
81Staphylococcus aureus infection_Homo sapiens_hsa051500.83426752
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.81717787
83Chemokine signaling pathway_Homo sapiens_hsa040620.80476989
84Pancreatic cancer_Homo sapiens_hsa052120.79380276
85Amoebiasis_Homo sapiens_hsa051460.78644273
86Basal transcription factors_Homo sapiens_hsa030220.78409225
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78341270
88Renin-angiotensin system_Homo sapiens_hsa046140.77581967
89Prolactin signaling pathway_Homo sapiens_hsa049170.76391854
90Homologous recombination_Homo sapiens_hsa034400.74773964
91Non-homologous end-joining_Homo sapiens_hsa034500.73545104
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73527069
93Selenocompound metabolism_Homo sapiens_hsa004500.73451395
94Pentose phosphate pathway_Homo sapiens_hsa000300.72119744
95Nucleotide excision repair_Homo sapiens_hsa034200.71538188
96Prostate cancer_Homo sapiens_hsa052150.71076568
97Maturity onset diabetes of the young_Homo sapiens_hsa049500.70809778
98Colorectal cancer_Homo sapiens_hsa052100.70702669
99Phagosome_Homo sapiens_hsa041450.68545425
100Proteoglycans in cancer_Homo sapiens_hsa052050.68005115
101Hedgehog signaling pathway_Homo sapiens_hsa043400.67403839
102Oocyte meiosis_Homo sapiens_hsa041140.67078510
103Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66414116
104African trypanosomiasis_Homo sapiens_hsa051430.65557621
105Ether lipid metabolism_Homo sapiens_hsa005650.64355052
106Type I diabetes mellitus_Homo sapiens_hsa049400.64278522
107Asthma_Homo sapiens_hsa053100.63129613
108Pyrimidine metabolism_Homo sapiens_hsa002400.62520290
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61983363
110Systemic lupus erythematosus_Homo sapiens_hsa053220.61755766
111Dorso-ventral axis formation_Homo sapiens_hsa043200.61714045
112One carbon pool by folate_Homo sapiens_hsa006700.61665802
113Regulation of autophagy_Homo sapiens_hsa041400.61589032
114Circadian rhythm_Homo sapiens_hsa047100.61471669
115RNA degradation_Homo sapiens_hsa030180.61441316
116HIF-1 signaling pathway_Homo sapiens_hsa040660.61301102
117Olfactory transduction_Homo sapiens_hsa047400.61238987
118mRNA surveillance pathway_Homo sapiens_hsa030150.60693314
119Basal cell carcinoma_Homo sapiens_hsa052170.60625088
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.60101227
121Insulin resistance_Homo sapiens_hsa049310.59612125
122Hippo signaling pathway_Homo sapiens_hsa043900.57910885
123Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57339817
124FoxO signaling pathway_Homo sapiens_hsa040680.55323138
125RNA polymerase_Homo sapiens_hsa030200.55240824
126Serotonergic synapse_Homo sapiens_hsa047260.55034241
127Wnt signaling pathway_Homo sapiens_hsa043100.51145416
128Hepatitis C_Homo sapiens_hsa051600.50736462
129Thyroid cancer_Homo sapiens_hsa052160.50631469
130Fanconi anemia pathway_Homo sapiens_hsa034600.49731656
131Propanoate metabolism_Homo sapiens_hsa006400.49187895
132Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.49117663
133Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48216937
134Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.41996699
135Taste transduction_Homo sapiens_hsa047420.39516021
136Pathways in cancer_Homo sapiens_hsa052000.37560026
137alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32324761
138Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28798678
139Lysine degradation_Homo sapiens_hsa003100.27380557
140SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26925253
141Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.26438128
142Linoleic acid metabolism_Homo sapiens_hsa005910.25906716
143Autoimmune thyroid disease_Homo sapiens_hsa053200.24075332
144Morphine addiction_Homo sapiens_hsa050320.23737906
145Long-term depression_Homo sapiens_hsa047300.21471396
146Glioma_Homo sapiens_hsa052140.19845050
147Glycerolipid metabolism_Homo sapiens_hsa005610.17242423

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