DPY19L2P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.68803052
2nucleobase catabolic process (GO:0046113)4.66225441
3nonmotile primary cilium assembly (GO:0035058)3.60616133
4presynaptic membrane assembly (GO:0097105)3.54859373
5synapsis (GO:0007129)3.24825414
6positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.23448548
7regulation of cilium movement (GO:0003352)3.15572314
8presynaptic membrane organization (GO:0097090)3.11632440
9postsynaptic membrane organization (GO:0001941)3.10786554
10response to pheromone (GO:0019236)3.06488562
11membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.01480333
12positive regulation of mitochondrial fission (GO:0090141)3.00961938
13neuron cell-cell adhesion (GO:0007158)2.99455091
14intraciliary transport (GO:0042073)2.96468041
15behavioral response to nicotine (GO:0035095)2.93455499
16gamma-aminobutyric acid transport (GO:0015812)2.93149576
17potassium ion import (GO:0010107)2.88806181
18positive regulation of protein homodimerization activity (GO:0090073)2.83885509
19retinal rod cell development (GO:0046548)2.83364498
20regulation of feeding behavior (GO:0060259)2.82649495
21vocalization behavior (GO:0071625)2.77608757
22G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.77436041
23regulation of microtubule-based movement (GO:0060632)2.74573148
24cilium organization (GO:0044782)2.71198607
25synaptic transmission, glutamatergic (GO:0035249)2.71079432
26cGMP biosynthetic process (GO:0006182)2.69168668
27spinal cord development (GO:0021510)2.69090423
28piRNA metabolic process (GO:0034587)2.67952506
29histone H4-K12 acetylation (GO:0043983)2.67531422
30neurotransmitter catabolic process (GO:0042135)2.66825197
31protein localization to synapse (GO:0035418)2.64329563
32cilium assembly (GO:0042384)2.64206904
33positive regulation of dendritic spine morphogenesis (GO:0061003)2.63576820
34protein localization to cilium (GO:0061512)2.60931741
35glutamate receptor signaling pathway (GO:0007215)2.59763079
36neurofilament cytoskeleton organization (GO:0060052)2.59664271
37cGMP metabolic process (GO:0046068)2.58532301
38positive regulation of potassium ion transmembrane transport (GO:1901381)2.55761959
39transmission of nerve impulse (GO:0019226)2.55456104
40glycosphingolipid biosynthetic process (GO:0006688)2.50625396
41hippocampus development (GO:0021766)2.50023242
42auditory behavior (GO:0031223)2.49977536
43negative regulation of synaptic transmission, GABAergic (GO:0032229)2.49861688
44positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.48990836
45DNA damage response, detection of DNA damage (GO:0042769)2.48566910
46neuron-neuron synaptic transmission (GO:0007270)2.48239804
47seminiferous tubule development (GO:0072520)2.47060707
48retinal cone cell development (GO:0046549)2.44933092
49male meiosis (GO:0007140)2.44731478
50regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.43776649
51regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.42669706
52cellular potassium ion homeostasis (GO:0030007)2.38454083
53neuronal action potential (GO:0019228)2.37792492
54photoreceptor cell maintenance (GO:0045494)2.36887466
55detection of calcium ion (GO:0005513)2.36643977
56ionotropic glutamate receptor signaling pathway (GO:0035235)2.36330622
57negative regulation of cytosolic calcium ion concentration (GO:0051481)2.36300510
58retinal ganglion cell axon guidance (GO:0031290)2.35896644
59regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.35617163
60acrosome reaction (GO:0007340)2.33832217
61regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.33533304
62neurotransmitter-gated ion channel clustering (GO:0072578)2.31763975
63synaptic vesicle maturation (GO:0016188)2.31376573
64establishment of protein localization to mitochondrial membrane (GO:0090151)2.29983634
65establishment of mitochondrion localization (GO:0051654)2.29556482
66acrosome assembly (GO:0001675)2.29450683
67short-term memory (GO:0007614)2.29403115
68positive regulation of meiosis (GO:0045836)2.28344704
69C4-dicarboxylate transport (GO:0015740)2.25864921
70regulation of sarcomere organization (GO:0060297)2.25829595
71negative regulation of DNA-dependent DNA replication (GO:2000104)2.24662683
72regulation of DNA endoreduplication (GO:0032875)2.24576149
73inner ear receptor stereocilium organization (GO:0060122)2.24279480
74epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.23320034
75regulation of membrane repolarization (GO:0060306)2.23155162
76epithelial cilium movement (GO:0003351)2.21949170
77detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.21534351
78axonal fasciculation (GO:0007413)2.21470654
79establishment of melanosome localization (GO:0032401)2.20950018
80cilium morphogenesis (GO:0060271)2.20519842
81positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.19257956
82heparin metabolic process (GO:0030202)2.18251653
83heparin biosynthetic process (GO:0030210)2.18251653
84regulation of dendritic spine morphogenesis (GO:0061001)2.17872366
85cellular component assembly involved in morphogenesis (GO:0010927)2.17649916
86regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.17550543
87regulation of short-term neuronal synaptic plasticity (GO:0048172)2.17004264
88neuron recognition (GO:0008038)2.16194650
89negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.15948975
90neuron fate determination (GO:0048664)2.15551778
91limb development (GO:0060173)2.15461832
92appendage development (GO:0048736)2.15461832
93resolution of meiotic recombination intermediates (GO:0000712)2.15298059
94male meiosis I (GO:0007141)2.14828431
95glutamate secretion (GO:0014047)2.14381718
96histone H2A acetylation (GO:0043968)2.14303987
97regulation of synapse structural plasticity (GO:0051823)2.13820492
98neurotransmitter secretion (GO:0007269)2.13529149
99positive regulation of receptor internalization (GO:0002092)2.13006521
100positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.12899108

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.68114962
2GBX2_23144817_ChIP-Seq_PC3_Human3.31601614
3POU3F2_20337985_ChIP-ChIP_501MEL_Human2.95874819
4TAF15_26573619_Chip-Seq_HEK293_Human2.82700488
5FUS_26573619_Chip-Seq_HEK293_Human2.79564985
6NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.74615369
7IGF1R_20145208_ChIP-Seq_DFB_Human2.71371075
8VDR_22108803_ChIP-Seq_LS180_Human2.60607644
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.58465119
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.44432720
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.28734968
12EWS_26573619_Chip-Seq_HEK293_Human2.27949969
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.27105078
14ZNF274_21170338_ChIP-Seq_K562_Hela2.26784357
15* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.26183017
16CBX2_27304074_Chip-Seq_ESCs_Mouse2.14887305
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.14575104
18* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.09262659
19RNF2_27304074_Chip-Seq_NSC_Mouse2.04019300
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.00579628
21* P300_19829295_ChIP-Seq_ESCs_Human1.99253301
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.94624191
23SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.86419318
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.83019415
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.81107748
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.80432326
27SMAD4_21799915_ChIP-Seq_A2780_Human1.72992475
28PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.71835411
29REST_21632747_ChIP-Seq_MESCs_Mouse1.68123713
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.65137754
31* ER_23166858_ChIP-Seq_MCF-7_Human1.62612093
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61256677
33SMAD3_21741376_ChIP-Seq_EPCs_Human1.59158800
34* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.57798808
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.57493171
36EZH2_27304074_Chip-Seq_ESCs_Mouse1.56562843
37* PIAS1_25552417_ChIP-Seq_VCAP_Human1.55038427
38MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.54863995
39OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52841365
40AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.50465954
41SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47614017
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.47581989
43UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47331002
44BCAT_22108803_ChIP-Seq_LS180_Human1.47217273
45JARID2_20064375_ChIP-Seq_MESCs_Mouse1.46142187
46SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.45044752
47REST_18959480_ChIP-ChIP_MESCs_Mouse1.44807847
48EED_16625203_ChIP-ChIP_MESCs_Mouse1.44799259
49* AR_25329375_ChIP-Seq_VCAP_Human1.43560481
50CBP_20019798_ChIP-Seq_JUKART_Human1.39621059
51IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39621059
52* STAT3_23295773_ChIP-Seq_U87_Human1.39283092
53SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.35216904
54TCF4_23295773_ChIP-Seq_U87_Human1.34668449
55RUNX2_22187159_ChIP-Seq_PCA_Human1.33280265
56POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.32881925
57TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32881925
58POU5F1_16153702_ChIP-ChIP_HESCs_Human1.32448510
59KLF5_20875108_ChIP-Seq_MESCs_Mouse1.29933593
60TAL1_26923725_Chip-Seq_HPCs_Mouse1.24809840
61FLI1_27457419_Chip-Seq_LIVER_Mouse1.23817578
62RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.23314427
63NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22617321
64* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21770088
65MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21705588
66FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.19523255
67SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.18930119
68* TCF4_22108803_ChIP-Seq_LS180_Human1.17530808
69CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17221221
70SOX2_21211035_ChIP-Seq_LN229_Gbm1.15345538
71JUN_21703547_ChIP-Seq_K562_Human1.14823240
72NANOG_18555785_Chip-Seq_ESCs_Mouse1.14808119
73IRF1_19129219_ChIP-ChIP_H3396_Human1.13612101
74RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12993557
75SOX9_26525672_Chip-Seq_HEART_Mouse1.11376248
76TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11106752
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10762974
78GABP_17652178_ChIP-ChIP_JURKAT_Human1.10014720
79TP53_22573176_ChIP-Seq_HFKS_Human1.07956661
80PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07821900
81KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.07340778
82TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06276739
83MYC_18940864_ChIP-ChIP_HL60_Human1.03094313
84SOX2_19829295_ChIP-Seq_ESCs_Human1.01852424
85NANOG_19829295_ChIP-Seq_ESCs_Human1.01852424
86EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01199157
87SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.00051027
88SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.99970841
89HTT_18923047_ChIP-ChIP_STHdh_Human0.98968365
90STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.98669038
91AR_21572438_ChIP-Seq_LNCaP_Human0.98614075
92P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98575342
93JARID2_20075857_ChIP-Seq_MESCs_Mouse0.97269211
94SOX2_16153702_ChIP-ChIP_HESCs_Human0.97249605
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96667770
96KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.96061819
97LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95083715
98EST1_17652178_ChIP-ChIP_JURKAT_Human0.94796691
99HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.94124694
100PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.93976643

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001984_abnormal_olfaction2.93139877
2MP0003880_abnormal_central_pattern2.69510158
3MP0008877_abnormal_DNA_methylation2.34718703
4MP0003890_abnormal_embryonic-extraembry2.31118383
5MP0006292_abnormal_olfactory_placode2.30911173
6MP0001529_abnormal_vocalization2.21860970
7MP0004859_abnormal_synaptic_plasticity2.19771568
8MP0004270_analgesia2.15275651
9MP0005499_abnormal_olfactory_system2.14515528
10MP0005394_taste/olfaction_phenotype2.14515528
11MP0003136_yellow_coat_color2.11559986
12MP0009046_muscle_twitch2.11082778
13MP0005423_abnormal_somatic_nervous2.10413609
14MP0005084_abnormal_gallbladder_morpholo2.01883963
15MP0008789_abnormal_olfactory_epithelium2.01524168
16MP0003635_abnormal_synaptic_transmissio2.00485388
17MP0002736_abnormal_nociception_after1.93402724
18MP0001968_abnormal_touch/_nociception1.90128724
19MP0000778_abnormal_nervous_system1.87415125
20MP0002272_abnormal_nervous_system1.82621991
21MP0001486_abnormal_startle_reflex1.79655704
22MP0003122_maternal_imprinting1.75436548
23MP0002837_dystrophic_cardiac_calcinosis1.74666201
24MP0002063_abnormal_learning/memory/cond1.72864309
25MP0002734_abnormal_mechanical_nocicepti1.72228921
26MP0006276_abnormal_autonomic_nervous1.70763540
27MP0009745_abnormal_behavioral_response1.67083898
28MP0000569_abnormal_digit_pigmentation1.64416403
29MP0005646_abnormal_pituitary_gland1.63679317
30MP0002572_abnormal_emotion/affect_behav1.63274099
31MP0000631_abnormal_neuroendocrine_gland1.61652973
32MP0008995_early_reproductive_senescence1.57181930
33MP0004215_abnormal_myocardial_fiber1.53635929
34MP0002064_seizures1.52600642
35MP0002653_abnormal_ependyma_morphology1.49488143
36MP0005551_abnormal_eye_electrophysiolog1.49151460
37MP0001188_hyperpigmentation1.44668090
38MP0002733_abnormal_thermal_nociception1.41378124
39MP0002160_abnormal_reproductive_system1.41356410
40MP0002638_abnormal_pupillary_reflex1.40687435
41MP0005187_abnormal_penis_morphology1.39216844
42MP0002067_abnormal_sensory_capabilities1.35524263
43MP0001970_abnormal_pain_threshold1.32469216
44MP0003787_abnormal_imprinting1.30630050
45MP0002557_abnormal_social/conspecific_i1.28890872
46MP0004085_abnormal_heartbeat1.27471859
47MP0006072_abnormal_retinal_apoptosis1.25918040
48MP0000955_abnormal_spinal_cord1.24775847
49MP0003119_abnormal_digestive_system1.23878228
50MP0004811_abnormal_neuron_physiology1.23572408
51MP0002184_abnormal_innervation1.19803297
52MP0004133_heterotaxia1.19587088
53MP0001485_abnormal_pinna_reflex1.18666069
54MP0000049_abnormal_middle_ear1.18054595
55MP0005253_abnormal_eye_physiology1.15814719
56MP0002735_abnormal_chemical_nociception1.14848512
57MP0002882_abnormal_neuron_morphology1.14672811
58MP0004142_abnormal_muscle_tone1.14423074
59MP0008058_abnormal_DNA_repair1.13247975
60MP0005386_behavior/neurological_phenoty1.11137258
61MP0004924_abnormal_behavior1.11137258
62MP0006035_abnormal_mitochondrial_morpho1.10366537
63MP0003121_genomic_imprinting1.09956314
64MP0002102_abnormal_ear_morphology1.08464548
65MP0004145_abnormal_muscle_electrophysio1.07148281
66MP0001501_abnormal_sleep_pattern1.06993456
67MP0000647_abnormal_sebaceous_gland1.03385780
68MP0002229_neurodegeneration1.01379625
69MP0003137_abnormal_impulse_conducting0.99836510
70MP0005645_abnormal_hypothalamus_physiol0.99324271
71MP0003698_abnormal_male_reproductive0.98705292
72MP0001502_abnormal_circadian_rhythm0.97445451
73MP0002233_abnormal_nose_morphology0.96440118
74MP0002066_abnormal_motor_capabilities/c0.95404143
75MP0003633_abnormal_nervous_system0.94883242
76MP0002210_abnormal_sex_determination0.93330008
77MP0002752_abnormal_somatic_nervous0.92139506
78MP0004885_abnormal_endolymph0.92113329
79MP0001929_abnormal_gametogenesis0.92097983
80MP0008569_lethality_at_weaning0.91996337
81MP0002152_abnormal_brain_morphology0.91258486
82MP0002090_abnormal_vision0.91166225
83MP0002751_abnormal_autonomic_nervous0.89620597
84MP0002234_abnormal_pharynx_morphology0.89325819
85MP0002928_abnormal_bile_duct0.89302901
86MP0003567_abnormal_fetal_cardiomyocyte0.88788464
87MP0000566_synostosis0.87687217
88MP0001293_anophthalmia0.86981711
89MP0003937_abnormal_limbs/digits/tail_de0.86139136
90MP0001664_abnormal_digestion0.82273873
91MP0004043_abnormal_pH_regulation0.81935409
92MP0001963_abnormal_hearing_physiology0.81846095
93MP0002822_catalepsy0.79019838
94MP0005410_abnormal_fertilization0.78456637
95MP0005195_abnormal_posterior_eye0.77730643
96MP0004147_increased_porphyrin_level0.77232045
97MP0000026_abnormal_inner_ear0.74969023
98MP0004742_abnormal_vestibular_system0.73909621
99MP0003861_abnormal_nervous_system0.73295069
100MP0000230_abnormal_systemic_arterial0.72063499

Predicted human phenotypes

RankGene SetZ-score
1Medial flaring of the eyebrow (HP:0010747)3.82157144
2Gait imbalance (HP:0002141)3.72423180
3Congenital primary aphakia (HP:0007707)3.54666119
4Focal motor seizures (HP:0011153)3.25603933
5Nephrogenic diabetes insipidus (HP:0009806)3.15097182
6Nephronophthisis (HP:0000090)2.99732817
7Genital tract atresia (HP:0001827)2.92923211
8Vaginal atresia (HP:0000148)2.80202596
9Limb dystonia (HP:0002451)2.75324131
10Abnormality of the labia minora (HP:0012880)2.72716665
11True hermaphroditism (HP:0010459)2.71802057
12Oligodactyly (hands) (HP:0001180)2.67291872
13Focal seizures (HP:0007359)2.64295007
14Degeneration of the lateral corticospinal tracts (HP:0002314)2.61319394
15Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.61319394
16Type II lissencephaly (HP:0007260)2.60030813
17Myokymia (HP:0002411)2.59972492
18Amyotrophic lateral sclerosis (HP:0007354)2.59764510
19Poor coordination (HP:0002370)2.58190924
20Hyperventilation (HP:0002883)2.56698889
21Abnormality of the corticospinal tract (HP:0002492)2.56138925
22Pancreatic fibrosis (HP:0100732)2.54427890
23Epileptiform EEG discharges (HP:0011182)2.51928062
24Epileptic encephalopathy (HP:0200134)2.50230742
25Progressive cerebellar ataxia (HP:0002073)2.48829494
26EEG with generalized epileptiform discharges (HP:0011198)2.48373478
27Specific learning disability (HP:0001328)2.47338298
28Atonic seizures (HP:0010819)2.46197922
29Hypsarrhythmia (HP:0002521)2.45733437
30Septo-optic dysplasia (HP:0100842)2.40413656
31Abnormality of the renal medulla (HP:0100957)2.36638167
32Hyperglycinemia (HP:0002154)2.32479039
33Drooling (HP:0002307)2.30266484
34Abnormality of midbrain morphology (HP:0002418)2.27951175
35Molar tooth sign on MRI (HP:0002419)2.27951175
36Febrile seizures (HP:0002373)2.26366187
37Pancreatic cysts (HP:0001737)2.25525009
38Retinal dysplasia (HP:0007973)2.24485633
39Generalized tonic-clonic seizures (HP:0002069)2.23571218
40Lissencephaly (HP:0001339)2.20581351
41Spastic tetraplegia (HP:0002510)2.19767244
42Dysdiadochokinesis (HP:0002075)2.12833728
43Urinary urgency (HP:0000012)2.12438358
44Attenuation of retinal blood vessels (HP:0007843)2.12358097
45Morphological abnormality of the pyramidal tract (HP:0002062)2.12180364
46Dialeptic seizures (HP:0011146)2.12151295
47Bundle branch block (HP:0011710)2.07675249
48Volvulus (HP:0002580)2.07079180
49Left ventricular hypertrophy (HP:0001712)2.06521086
50Postaxial hand polydactyly (HP:0001162)2.06447781
51Type I transferrin isoform profile (HP:0003642)2.05501360
52Polyphagia (HP:0002591)2.05459053
53Hemiparesis (HP:0001269)2.04883535
54Shoulder girdle muscle weakness (HP:0003547)2.03100161
55Abnormal protein glycosylation (HP:0012346)2.03077223
56Abnormal glycosylation (HP:0012345)2.03077223
57Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.03077223
58Abnormal protein N-linked glycosylation (HP:0012347)2.03077223
59Split foot (HP:0001839)2.02205595
60Broad-based gait (HP:0002136)2.00749309
61Excessive salivation (HP:0003781)2.00246105
62Atrophy/Degeneration involving motor neurons (HP:0007373)1.95576637
63Methylmalonic acidemia (HP:0002912)1.94649575
64Gaze-evoked nystagmus (HP:0000640)1.93515207
65Broad foot (HP:0001769)1.91427755
66Aplasia/Hypoplasia of the lens (HP:0008063)1.91147839
67Atrial fibrillation (HP:0005110)1.90507190
68Postaxial foot polydactyly (HP:0001830)1.89901777
69Syncope (HP:0001279)1.89611393
70Delayed myelination (HP:0012448)1.89167694
71Prominent supraorbital ridges (HP:0000336)1.88952213
72Absence seizures (HP:0002121)1.85247962
73Generalized myoclonic seizures (HP:0002123)1.84023082
74Genetic anticipation (HP:0003743)1.82099643
75Short foot (HP:0001773)1.80065611
76Primary atrial arrhythmia (HP:0001692)1.79607725
77Intestinal atresia (HP:0011100)1.79491750
78Oligodactyly (HP:0012165)1.78934020
79Optic nerve hypoplasia (HP:0000609)1.78611002
80Horizontal nystagmus (HP:0000666)1.77716017
81Aplasia/Hypoplasia of the tibia (HP:0005772)1.77431790
82Abolished electroretinogram (ERG) (HP:0000550)1.76204719
83Aplasia/Hypoplasia of the tongue (HP:0010295)1.76131398
84Tubulointerstitial nephritis (HP:0001970)1.75971410
85Congenital hepatic fibrosis (HP:0002612)1.75933017
86Decreased testicular size (HP:0008734)1.75545186
87Pachygyria (HP:0001302)1.75538785
88Preaxial hand polydactyly (HP:0001177)1.74130851
89Cortical dysplasia (HP:0002539)1.73810845
90Preaxial foot polydactyly (HP:0001841)1.73719094
91Sclerocornea (HP:0000647)1.73385279
92Supraventricular tachycardia (HP:0004755)1.70652841
93Retinitis pigmentosa (HP:0000510)1.69681415
94Colon cancer (HP:0003003)1.69316954
95Ulnar claw (HP:0001178)1.67436793
96Aplasia/Hypoplasia of the hallux (HP:0008362)1.65917812
97Supraventricular arrhythmia (HP:0005115)1.65805672
98Abnormality of the astrocytes (HP:0100707)1.65437103
99Astrocytoma (HP:0009592)1.65437103
100Short tibia (HP:0005736)1.65231194

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK13.45685461
2PRKD33.37971325
3CASK3.18694529
4PNCK3.12957589
5MAP4K22.99873457
6MARK12.83833024
7BMPR1B2.83218500
8MAP2K72.64535993
9FRK2.54913996
10MAP3K42.54860510
11MAPK132.08967598
12IRAK21.93402214
13BCR1.81492404
14CSNK1G21.81384955
15WNK31.71612202
16CSNK1G31.61764658
17CSNK1G11.60938365
18EPHA41.58976530
19PLK21.55851745
20ERBB31.49346195
21NTRK31.37600121
22DYRK21.37234320
23CSNK1A1L1.32313489
24ACVR1B1.27881870
25CDK31.19063153
26MAP2K41.15624713
27STK38L1.15308240
28CAMKK21.15216227
29MET1.11738897
30NTRK21.09075438
31TNIK1.08837765
32MINK11.07618338
33PRKCE1.06375132
34PAK31.02731061
35CDK190.99808111
36PHKG20.96638547
37PHKG10.96638547
38PAK60.96595520
39PRKCG0.92052044
40CAMK2A0.91285703
41TSSK60.87923369
42IRAK10.87010114
43DAPK20.86813611
44OXSR10.86071769
45PTK2B0.84792902
46VRK10.84408961
47RPS6KA40.81448177
48CAMK10.81164137
49PLK30.76816926
50PIK3CA0.75882568
51MAPK150.70971391
52STK390.70794052
53DMPK0.70489247
54INSRR0.67839968
55BRSK20.67695111
56MKNK10.66190663
57FLT30.65434659
58NEK10.64413694
59ADRBK20.63073528
60TGFBR10.62178652
61ADRBK10.61849674
62CSNK1E0.61114618
63NUAK10.59930268
64UHMK10.59707376
65WNK40.59508395
66OBSCN0.59442835
67PKN10.57871004
68TIE10.57595689
69CDK50.57350928
70DYRK1A0.56612990
71FGFR20.55982179
72CDK80.55822624
73TRIM280.55528374
74SRPK10.54038298
75CAMK2B0.53603694
76RPS6KA50.52950847
77TAOK30.52830762
78CSNK1A10.52316148
79MAPKAPK50.52042185
80PRKG10.51512808
81DYRK30.51419669
82SGK2230.51405227
83SGK4940.51405227
84CAMK2D0.50806616
85EPHA30.49986669
86BUB10.48601360
87PRKACA0.46968555
88EIF2AK30.45495386
89DYRK1B0.45183867
90PRKACB0.44844756
91EPHB20.44044196
92KSR10.43346119
93PRKAA10.42208943
94PLK10.42169837
95TTK0.42002161
96BCKDK0.39529171
97WEE10.38965666
98PASK0.38910620
99YES10.38470547
100MAP3K60.37376277

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.29242923
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.31286131
3Oxidative phosphorylation_Homo sapiens_hsa001902.17457255
4Cardiac muscle contraction_Homo sapiens_hsa042602.15871555
5Protein export_Homo sapiens_hsa030602.11319078
6Butanoate metabolism_Homo sapiens_hsa006502.02258836
7GABAergic synapse_Homo sapiens_hsa047272.00317595
8Parkinsons disease_Homo sapiens_hsa050121.95037909
9Circadian entrainment_Homo sapiens_hsa047131.83623805
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.78223436
11Taste transduction_Homo sapiens_hsa047421.73039231
12Collecting duct acid secretion_Homo sapiens_hsa049661.66742286
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.65663607
14Synaptic vesicle cycle_Homo sapiens_hsa047211.64298761
15Phototransduction_Homo sapiens_hsa047441.62311076
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.60415426
17Renin secretion_Homo sapiens_hsa049241.57065018
18Morphine addiction_Homo sapiens_hsa050321.55403183
19Long-term depression_Homo sapiens_hsa047301.54838655
20Olfactory transduction_Homo sapiens_hsa047401.51115445
21Glutamatergic synapse_Homo sapiens_hsa047241.48700256
22Propanoate metabolism_Homo sapiens_hsa006401.46451300
23Cocaine addiction_Homo sapiens_hsa050301.46124457
24Basal transcription factors_Homo sapiens_hsa030221.45918305
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.45442703
26Steroid biosynthesis_Homo sapiens_hsa001001.43246894
27beta-Alanine metabolism_Homo sapiens_hsa004101.33340106
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.29729777
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.26629057
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.24992705
31RNA degradation_Homo sapiens_hsa030181.23654020
32Amphetamine addiction_Homo sapiens_hsa050311.23556903
33Dopaminergic synapse_Homo sapiens_hsa047281.22678020
34Huntingtons disease_Homo sapiens_hsa050161.22109348
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.19579799
36Alzheimers disease_Homo sapiens_hsa050101.19457887
37Regulation of autophagy_Homo sapiens_hsa041401.17199393
38Insulin secretion_Homo sapiens_hsa049111.15507103
39Gap junction_Homo sapiens_hsa045401.14372308
40Peroxisome_Homo sapiens_hsa041461.13781351
41Selenocompound metabolism_Homo sapiens_hsa004501.13166382
42Salivary secretion_Homo sapiens_hsa049701.09852263
43Linoleic acid metabolism_Homo sapiens_hsa005911.08051079
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.07910512
45Circadian rhythm_Homo sapiens_hsa047101.03588117
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.02397392
47Oxytocin signaling pathway_Homo sapiens_hsa049211.01519928
48Tryptophan metabolism_Homo sapiens_hsa003800.99024582
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95722796
50Fatty acid elongation_Homo sapiens_hsa000620.95596983
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.93796849
52Serotonergic synapse_Homo sapiens_hsa047260.93330266
53Ether lipid metabolism_Homo sapiens_hsa005650.93324958
54Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.93129401
55cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90761803
56Oocyte meiosis_Homo sapiens_hsa041140.89745604
57Hedgehog signaling pathway_Homo sapiens_hsa043400.88004037
58Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.86781152
59Pyruvate metabolism_Homo sapiens_hsa006200.83812186
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.79899344
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.75362888
62RNA polymerase_Homo sapiens_hsa030200.75051089
63Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.75015169
64Purine metabolism_Homo sapiens_hsa002300.74776971
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73536476
66Calcium signaling pathway_Homo sapiens_hsa040200.73363570
67Nitrogen metabolism_Homo sapiens_hsa009100.72670163
68Gastric acid secretion_Homo sapiens_hsa049710.71609542
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70356083
70Fatty acid metabolism_Homo sapiens_hsa012120.69374328
71mRNA surveillance pathway_Homo sapiens_hsa030150.69341871
72Fanconi anemia pathway_Homo sapiens_hsa034600.67878744
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.67055036
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65887260
75RNA transport_Homo sapiens_hsa030130.65369901
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.63430030
77Vibrio cholerae infection_Homo sapiens_hsa051100.61607663
78Axon guidance_Homo sapiens_hsa043600.61391603
79Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61243684
80Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.59544652
81Dilated cardiomyopathy_Homo sapiens_hsa054140.59013207
82Cholinergic synapse_Homo sapiens_hsa047250.58292790
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56952217
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.55014457
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.54902840
86cAMP signaling pathway_Homo sapiens_hsa040240.54074657
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53207055
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.52173893
89Metabolic pathways_Homo sapiens_hsa011000.51929436
90Arginine and proline metabolism_Homo sapiens_hsa003300.51396873
91Sulfur relay system_Homo sapiens_hsa041220.50404652
92Caffeine metabolism_Homo sapiens_hsa002320.49747731
93Base excision repair_Homo sapiens_hsa034100.46955525
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44578039
95N-Glycan biosynthesis_Homo sapiens_hsa005100.44011457
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40913379
97Fatty acid degradation_Homo sapiens_hsa000710.40787479
98Wnt signaling pathway_Homo sapiens_hsa043100.38674330
99Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.38302214
100Hippo signaling pathway_Homo sapiens_hsa043900.37666511

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