DPY19L2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO7.01276523
2regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)6.54798860
3cell communication by electrical coupling involved in cardiac conduction (GO:0086064)6.00362219
4regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.87694324
5positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.62475345
6cardiac myofibril assembly (GO:0055003)5.39535864
7regulation of actin filament-based movement (GO:1903115)5.18330915
8cell communication involved in cardiac conduction (GO:0086065)5.09604204
9cell communication by electrical coupling (GO:0010644)5.00166460
10membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.99985314
11cardiac muscle contraction (GO:0060048)4.95487700
12regulation of relaxation of muscle (GO:1901077)4.93150657
13sarcomere organization (GO:0045214)4.77368161
14myofibril assembly (GO:0030239)4.72438603
15regulation of cell communication by electrical coupling (GO:0010649)4.69761738
16regulation of cardiac muscle cell contraction (GO:0086004)4.56079970
17detection of calcium ion (GO:0005513)4.51274425
18cardiac muscle hypertrophy (GO:0003300)4.50500660
19relaxation of cardiac muscle (GO:0055119)4.40183570
20regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.34182023
21striated muscle hypertrophy (GO:0014897)4.24526189
22adult heart development (GO:0007512)4.08027753
23cardiac chamber formation (GO:0003207)4.03606232
24cardiac muscle cell development (GO:0055013)4.01150170
25ventricular cardiac muscle cell action potential (GO:0086005)3.99906351
26regulation of cardiac muscle contraction (GO:0055117)3.88376500
27regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.86134480
28regulation of the force of heart contraction (GO:0002026)3.85713922
29positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.80139179
30regulation of striated muscle contraction (GO:0006942)3.75827899
31cardiac cell development (GO:0055006)3.67654522
32cardiac muscle cell action potential (GO:0086001)3.63142436
33regulation of heart rate (GO:0002027)3.62441515
34muscle hypertrophy (GO:0014896)3.61641893
35cardiac ventricle formation (GO:0003211)3.60259553
36ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.58772501
37cardiac muscle tissue morphogenesis (GO:0055008)3.54556644
38response to caffeine (GO:0031000)3.50873890
39regulation of cardioblast differentiation (GO:0051890)3.50203102
40bundle of His cell to Purkinje myocyte communication (GO:0086069)3.45829022
41actin-myosin filament sliding (GO:0033275)3.44657180
42muscle filament sliding (GO:0030049)3.44657180
43striated muscle contraction (GO:0006941)3.43362413
44regulation of sarcomere organization (GO:0060297)3.40214816
45cardiac muscle cell action potential involved in contraction (GO:0086002)3.39821315
46negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.38700720
47adrenergic receptor signaling pathway (GO:0071875)3.33799385
48negative regulation of cytosolic calcium ion concentration (GO:0051481)3.31529775
49cardiac conduction (GO:0061337)3.31371369
50positive regulation of action potential (GO:0045760)3.25568543
51regulation of ATPase activity (GO:0043462)3.25554873
52regulation of ATP catabolic process (GO:1903289)3.25554873
53positive regulation of heart rate (GO:0010460)3.23536527
54regulation of membrane repolarization (GO:0060306)3.22939410
55actomyosin structure organization (GO:0031032)3.22591143
56muscle tissue morphogenesis (GO:0060415)3.17985193
57sarcoplasmic reticulum calcium ion transport (GO:0070296)3.15217176
58relaxation of muscle (GO:0090075)3.04453936
59regulation of heart contraction (GO:0008016)3.01433340
60positive regulation of ATP catabolic process (GO:1903291)2.98663657
61positive regulation of ATPase activity (GO:0032781)2.98663657
62regulation of calcium ion transmembrane transport (GO:1903169)2.98628327
63regulation of calcium ion transmembrane transporter activity (GO:1901019)2.98628327
64positive regulation of cardiac muscle cell differentiation (GO:2000727)2.97848147
65membrane depolarization during action potential (GO:0086010)2.95466217
66positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.94073838
67negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.91195310
68actin-mediated cell contraction (GO:0070252)2.90308741
69heart contraction (GO:0060047)2.90228167
70heart process (GO:0003015)2.90228167
71regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.82831560
72positive regulation of sodium ion transport (GO:0010765)2.82269330
73multicellular organismal signaling (GO:0035637)2.79212842
74neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.77769859
75positive regulation of cation channel activity (GO:2001259)2.77086625
76regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.76093645
77cardiac muscle adaptation (GO:0014887)2.75635520
78cardiac muscle hypertrophy in response to stress (GO:0014898)2.75635520
79muscle hypertrophy in response to stress (GO:0003299)2.75635520
80response to epinephrine (GO:0071871)2.75114928
81cilium or flagellum-dependent cell motility (GO:0001539)2.70614562
82negative regulation of potassium ion transmembrane transport (GO:1901380)2.70323917
83negative regulation of calcium ion transmembrane transport (GO:1903170)2.68632860
84negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.68632860
85cerebral cortex radially oriented cell migration (GO:0021799)2.68056868
86atrial septum morphogenesis (GO:0060413)2.68026363
87epithelial cilium movement (GO:0003351)2.65396261
88positive regulation of cardiac muscle tissue growth (GO:0055023)2.64111906
89regulation of acyl-CoA biosynthetic process (GO:0050812)2.63836343
90positive regulation of heart contraction (GO:0045823)2.63596868
91regulation of cation channel activity (GO:2001257)2.62101078
92negative regulation of heart rate (GO:0010459)2.58349336
93relaxation of smooth muscle (GO:0044557)2.58115297
94regulation of voltage-gated calcium channel activity (GO:1901385)2.58072564
95negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.57471255
96cilium movement (GO:0003341)2.57421921
97sodium ion export (GO:0071436)2.57360677
98microtubule polymerization or depolymerization (GO:0031109)2.53941054
99motile cilium assembly (GO:0044458)2.52801015
100regulation of heart rate by cardiac conduction (GO:0086091)2.51801295

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.75565583
2EZH2_22144423_ChIP-Seq_EOC_Human3.65122778
3POU3F2_20337985_ChIP-ChIP_501MEL_Human2.83987814
4TAF15_26573619_Chip-Seq_HEK293_Human2.63632606
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.60965923
6VDR_22108803_ChIP-Seq_LS180_Human2.53766375
7FUS_26573619_Chip-Seq_HEK293_Human2.49764961
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.46695265
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.45478042
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.43290902
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.29661601
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.24405353
13SMAD4_21799915_ChIP-Seq_A2780_Human2.22001103
14RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.18495694
15AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.09573813
16SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.09485284
17IGF1R_20145208_ChIP-Seq_DFB_Human2.09432108
18PIAS1_25552417_ChIP-Seq_VCAP_Human2.08811108
19P300_19829295_ChIP-Seq_ESCs_Human2.07584001
20CDX2_19796622_ChIP-Seq_MESCs_Mouse2.05590280
21EP300_21415370_ChIP-Seq_HL-1_Mouse2.03571886
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97584777
23PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.96897257
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.96398559
25MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.87063638
26* STAT3_23295773_ChIP-Seq_U87_Human1.83745503
27SMAD3_21741376_ChIP-Seq_EPCs_Human1.80765970
28TOP2B_26459242_ChIP-Seq_MCF-7_Human1.77098835
29EWS_26573619_Chip-Seq_HEK293_Human1.75945595
30ZNF274_21170338_ChIP-Seq_K562_Hela1.73404883
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.72633935
32SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.70145361
33TCF4_23295773_ChIP-Seq_U87_Human1.68926470
34ER_23166858_ChIP-Seq_MCF-7_Human1.68487110
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.64296060
36SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64071068
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.63027124
38OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61530202
39NR3C1_21868756_ChIP-Seq_MCF10A_Human1.59290951
40TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56582492
41POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.56582492
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.56293575
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.53796734
44TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.52563677
45BCAT_22108803_ChIP-Seq_LS180_Human1.50509082
46RNF2_27304074_Chip-Seq_NSC_Mouse1.45331157
47SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.44768234
48EZH2_27304074_Chip-Seq_ESCs_Mouse1.41168417
49SOX2_21211035_ChIP-Seq_LN229_Gbm1.40495673
50PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40315663
51CBP_20019798_ChIP-Seq_JUKART_Human1.39251059
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39251059
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39019923
54SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.37365853
55AR_25329375_ChIP-Seq_VCAP_Human1.36299753
56TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35066433
57TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34299357
58RUNX2_22187159_ChIP-Seq_PCA_Human1.29276686
59EED_16625203_ChIP-ChIP_MESCs_Mouse1.28177505
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.28125551
61NANOG_18555785_Chip-Seq_ESCs_Mouse1.27791264
62JARID2_20064375_ChIP-Seq_MESCs_Mouse1.26026656
63TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.25913649
64EZH2_27294783_Chip-Seq_NPCs_Mouse1.25628161
65TCF4_22108803_ChIP-Seq_LS180_Human1.25090602
66TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23170968
67FOXM1_26456572_ChIP-Seq_MCF-7_Human1.22312203
68KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21447343
69SOX9_26525672_Chip-Seq_HEART_Mouse1.20805163
70REST_21632747_ChIP-Seq_MESCs_Mouse1.19907825
71LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18942282
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18867015
73TBL1_22424771_ChIP-Seq_293T_Human1.17507230
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15319261
75SMAD4_21741376_ChIP-Seq_EPCs_Human1.14977680
76BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13732101
77E2F1_18555785_Chip-Seq_ESCs_Mouse1.13676885
78EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13440575
79AR_21572438_ChIP-Seq_LNCaP_Human1.12122507
80CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.12066327
81FLI1_21867929_ChIP-Seq_TH2_Mouse1.11723048
82TAL1_26923725_Chip-Seq_HPCs_Mouse1.11453686
83SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.10395301
84SMAD4_21741376_ChIP-Seq_HESCs_Human1.09753788
85SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.09549449
86RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09468830
87NFE2_27457419_Chip-Seq_LIVER_Mouse1.08446332
88SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.07721708
89SMAD3_21741376_ChIP-Seq_HESCs_Human1.07656092
90CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07535502
91TP53_16413492_ChIP-PET_HCT116_Human1.07395870
92RNF2_18974828_ChIP-Seq_MESCs_Mouse1.06120506
93EZH2_18974828_ChIP-Seq_MESCs_Mouse1.06120506
94WT1_19549856_ChIP-ChIP_CCG9911_Human1.05442429
95CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04132326
96ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03987899
97TP53_18474530_ChIP-ChIP_U2OS_Human1.03584843
98FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.03064730
99DROSHA_22980978_ChIP-Seq_HELA_Human1.02549038
100P53_22387025_ChIP-Seq_ESCs_Mouse1.02230917

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle4.96932911
2MP0002837_dystrophic_cardiac_calcinosis4.43385233
3MP0004215_abnormal_myocardial_fiber4.35861599
4MP0004036_abnormal_muscle_relaxation3.18005165
5MP0000751_myopathy2.92596238
6MP0008775_abnormal_heart_ventricle2.75261435
7MP0003137_abnormal_impulse_conducting2.54022705
8MP0004510_myositis2.44583685
9MP0004484_altered_response_of2.44575519
10MP0002972_abnormal_cardiac_muscle2.23871251
11MP0005330_cardiomyopathy2.23180743
12MP0004085_abnormal_heartbeat2.20811716
13MP0003880_abnormal_central_pattern2.16801255
14MP0003646_muscle_fatigue2.09932940
15MP0001984_abnormal_olfaction1.84735929
16MP0009046_muscle_twitch1.84555977
17MP0004859_abnormal_synaptic_plasticity1.84379220
18MP0005620_abnormal_muscle_contractility1.80902276
19MP0004145_abnormal_muscle_electrophysio1.78367415
20MP0001486_abnormal_startle_reflex1.77673920
21MP0000749_muscle_degeneration1.74572805
22MP0009745_abnormal_behavioral_response1.67817502
23MP0005670_abnormal_white_adipose1.67067521
24MP0002127_abnormal_cardiovascular_syste1.59065450
25MP0001544_abnormal_cardiovascular_syste1.57733167
26MP0005385_cardiovascular_system_phenoty1.57733167
27MP0002272_abnormal_nervous_system1.54525054
28MP0006138_congestive_heart_failure1.52957183
29MP0002735_abnormal_chemical_nociception1.50658787
30MP0002064_seizures1.48780229
31MP0002234_abnormal_pharynx_morphology1.44747977
32MP0010630_abnormal_cardiac_muscle1.42624285
33MP0003635_abnormal_synaptic_transmissio1.42477299
34MP0008057_abnormal_DNA_replication1.39377222
35MP0004087_abnormal_muscle_fiber1.34993136
36MP0004130_abnormal_muscle_cell1.30680140
37MP0004147_increased_porphyrin_level1.30547042
38MP0005646_abnormal_pituitary_gland1.30041101
39MP0002572_abnormal_emotion/affect_behav1.26985020
40MP0001968_abnormal_touch/_nociception1.24960077
41MP0006276_abnormal_autonomic_nervous1.24902008
42MP0005187_abnormal_penis_morphology1.23941889
43MP0000569_abnormal_digit_pigmentation1.23259138
44MP0005551_abnormal_eye_electrophysiolog1.22676735
45MP0001501_abnormal_sleep_pattern1.21865280
46MP0002063_abnormal_learning/memory/cond1.20211166
47MP0002102_abnormal_ear_morphology1.19570155
48MP0002736_abnormal_nociception_after1.16900046
49MP0002269_muscular_atrophy1.16077703
50MP0002106_abnormal_muscle_physiology1.14881292
51MP0004924_abnormal_behavior1.14315839
52MP0005386_behavior/neurological_phenoty1.14315839
53MP0002638_abnormal_pupillary_reflex1.12088434
54MP0006072_abnormal_retinal_apoptosis1.12028223
55MP0005253_abnormal_eye_physiology1.10851411
56MP0010368_abnormal_lymphatic_system1.09195296
57MP0002067_abnormal_sensory_capabilities1.04755352
58MP0005423_abnormal_somatic_nervous0.99875097
59MP0002734_abnormal_mechanical_nocicepti0.98796095
60MP0008877_abnormal_DNA_methylation0.97607839
61MP0000778_abnormal_nervous_system0.97081350
62MP0005369_muscle_phenotype0.96296573
63MP0004270_analgesia0.93389156
64MP0003937_abnormal_limbs/digits/tail_de0.93293057
65MP0001529_abnormal_vocalization0.91455573
66MP0001970_abnormal_pain_threshold0.90707821
67MP0002557_abnormal_social/conspecific_i0.89675134
68MP0000631_abnormal_neuroendocrine_gland0.87115024
69MP0008569_lethality_at_weaning0.85924744
70MP0000383_abnormal_hair_follicle0.84406532
71MP0001485_abnormal_pinna_reflex0.83256664
72MP0003698_abnormal_male_reproductive0.82263104
73MP0005165_increased_susceptibility_to0.79879418
74MP0004043_abnormal_pH_regulation0.79832960
75MP0000747_muscle_weakness0.79344942
76MP0000266_abnormal_heart_morphology0.78661373
77MP0001177_atelectasis0.78496650
78MP0003136_yellow_coat_color0.75356462
79MP0005248_abnormal_Harderian_gland0.74568490
80MP0005410_abnormal_fertilization0.73876611
81MP0002882_abnormal_neuron_morphology0.72265836
82MP0000427_abnormal_hair_cycle0.71727773
83MP0002733_abnormal_thermal_nociception0.70892581
84MP0001963_abnormal_hearing_physiology0.68702953
85MP0003890_abnormal_embryonic-extraembry0.68502062
86MP0001299_abnormal_eye_distance/0.68247883
87MP0001929_abnormal_gametogenesis0.67267271
88MP0003633_abnormal_nervous_system0.66275058
89MP0002184_abnormal_innervation0.65709327
90MP0003787_abnormal_imprinting0.64447700
91MP0002066_abnormal_motor_capabilities/c0.63745734
92MP0005266_abnormal_metabolism0.63310198
93MP0010386_abnormal_urinary_bladder0.62957455
94MP0001346_abnormal_lacrimal_gland0.62828260
95MP0000230_abnormal_systemic_arterial0.62793805
96MP0002249_abnormal_larynx_morphology0.60864473
97MP0002752_abnormal_somatic_nervous0.60621983
98MP0002229_neurodegeneration0.59016397
99MP0003283_abnormal_digestive_organ0.58479841
100MP0003950_abnormal_plasma_membrane0.58226762

Predicted human phenotypes

RankGene SetZ-score
1Bundle branch block (HP:0011710)6.83188458
2Sudden death (HP:0001699)6.76188439
3Atrial fibrillation (HP:0005110)5.76291094
4Primary atrial arrhythmia (HP:0001692)5.28781111
5Syncope (HP:0001279)5.22001379
6Supraventricular tachycardia (HP:0004755)5.03767108
7Supraventricular arrhythmia (HP:0005115)4.88275609
8Ventricular tachycardia (HP:0004756)4.84339976
9Right ventricular cardiomyopathy (HP:0011663)4.32029451
10Abnormality of the calf musculature (HP:0001430)4.12638184
11Heart block (HP:0012722)4.11013150
12Lipoatrophy (HP:0100578)3.91748460
13Abnormal atrioventricular conduction (HP:0005150)3.66361698
14Focal motor seizures (HP:0011153)3.62122154
15Ventricular arrhythmia (HP:0004308)3.52837809
16Left ventricular hypertrophy (HP:0001712)3.40722449
17Calf muscle hypertrophy (HP:0008981)3.34433148
18Dilated cardiomyopathy (HP:0001644)3.26264642
19Subaortic stenosis (HP:0001682)3.19769121
20Abnormality of the left ventricular outflow tract (HP:0011103)3.19769121
21Hyporeflexia of lower limbs (HP:0002600)3.16423652
22Prolonged QT interval (HP:0001657)3.05872179
23Hyperventilation (HP:0002883)2.95952471
24Muscle fiber splitting (HP:0003555)2.91424355
25Abnormal EKG (HP:0003115)2.88286391
26Muscle hypertrophy of the lower extremities (HP:0008968)2.87829484
27Asymmetric septal hypertrophy (HP:0001670)2.87401352
28Central scotoma (HP:0000603)2.85373233
29Atrioventricular block (HP:0001678)2.83975839
30Febrile seizures (HP:0002373)2.75693072
31Myokymia (HP:0002411)2.73923214
32Tubulointerstitial nephritis (HP:0001970)2.71460078
33Chronic hepatic failure (HP:0100626)2.70683994
34Palpitations (HP:0001962)2.63208080
35Ventricular fibrillation (HP:0001663)2.62832390
36Atonic seizures (HP:0010819)2.60811156
37Gaze-evoked nystagmus (HP:0000640)2.52245603
38Focal seizures (HP:0007359)2.48487131
39Rimmed vacuoles (HP:0003805)2.40673085
40Medial flaring of the eyebrow (HP:0010747)2.37650054
41Nephronophthisis (HP:0000090)2.35341642
42EMG: neuropathic changes (HP:0003445)2.35002947
43Abnormal ciliary motility (HP:0012262)2.32080939
44Abnormal respiratory motile cilium physiology (HP:0012261)2.27041955
45Absent/shortened dynein arms (HP:0200106)2.26665017
46Dynein arm defect of respiratory motile cilia (HP:0012255)2.26665017
47Broad-based gait (HP:0002136)2.26053526
48Dialeptic seizures (HP:0011146)2.23554762
49Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.23179529
50Pancreatic cysts (HP:0001737)2.21413513
51Pancreatic fibrosis (HP:0100732)2.21393630
52Double outlet right ventricle (HP:0001719)2.16046726
53Congenital malformation of the right heart (HP:0011723)2.16046726
54True hermaphroditism (HP:0010459)2.12602044
55Drooling (HP:0002307)2.07868437
56EMG: myopathic abnormalities (HP:0003458)2.07840306
57Absence seizures (HP:0002121)2.06138483
58Steppage gait (HP:0003376)2.05616377
59Abnormality of the renal cortex (HP:0011035)2.02178634
60Gait imbalance (HP:0002141)2.00617708
61Abnormality of the renal medulla (HP:0100957)2.00424741
62Abnormal respiratory motile cilium morphology (HP:0005938)1.95531765
63Abnormal respiratory epithelium morphology (HP:0012253)1.95531765
64Congenital primary aphakia (HP:0007707)1.95022454
65Areflexia of lower limbs (HP:0002522)1.91955134
66Genital tract atresia (HP:0001827)1.90687497
67Progressive cerebellar ataxia (HP:0002073)1.90174950
68Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.88197864
69Vaginal atresia (HP:0000148)1.87525114
70Action tremor (HP:0002345)1.86989489
71Molar tooth sign on MRI (HP:0002419)1.84558952
72Abnormality of midbrain morphology (HP:0002418)1.84558952
73Scotoma (HP:0000575)1.83043630
74Excessive salivation (HP:0003781)1.79783354
75Ragged-red muscle fibers (HP:0003200)1.79380513
76Attenuation of retinal blood vessels (HP:0007843)1.79120535
77Rhinitis (HP:0012384)1.77690602
78Type II lissencephaly (HP:0007260)1.76815726
79Nephrogenic diabetes insipidus (HP:0009806)1.74161815
80Volvulus (HP:0002580)1.72243957
81Poor coordination (HP:0002370)1.70496410
82Hypoplastic left heart (HP:0004383)1.68343879
83Absent speech (HP:0001344)1.66992413
84Dysmetric saccades (HP:0000641)1.66371252
85Cystic liver disease (HP:0006706)1.65079810
86Genetic anticipation (HP:0003743)1.65056354
87Hemiparesis (HP:0001269)1.65046847
88Bradycardia (HP:0001662)1.64852169
89Abnormality of macular pigmentation (HP:0008002)1.63920161
90Toxemia of pregnancy (HP:0100603)1.62896438
91Abnormality of the corticospinal tract (HP:0002492)1.59744648
92Epileptic encephalopathy (HP:0200134)1.59723104
93Abnormality of the foot musculature (HP:0001436)1.58598207
94Astrocytoma (HP:0009592)1.57952937
95Abnormality of the astrocytes (HP:0100707)1.57952937
96Postaxial foot polydactyly (HP:0001830)1.57374797
97Generalized tonic-clonic seizures (HP:0002069)1.56600270
98Abnormal drinking behavior (HP:0030082)1.55971921
99Polydipsia (HP:0001959)1.55971921
100Preaxial foot polydactyly (HP:0001841)1.55335341

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN3.77356830
2FRK3.61806311
3MYLK3.26271521
4EPHA43.10065521
5DMPK2.84966287
6PLK42.56482865
7WNK32.35673933
8STK38L2.33134867
9MAP4K22.30207450
10MARK12.26407477
11PNCK1.89573020
12PINK11.88510454
13MAP3K41.82409931
14BMPR1B1.80649349
15MKNK21.74960328
16CASK1.66794658
17PIK3CA1.59709345
18TTN1.59044474
19PLK21.53381024
20PAK31.53195718
21LATS11.50395482
22ACVR1B1.47090933
23INSRR1.45965313
24FLT31.45625202
25NTRK31.45163580
26PKN21.44065137
27ERBB31.43606117
28MAPK131.40299955
29TRPM71.39455460
30CAMK2A1.32138720
31BRSK21.30306525
32PRKCE1.30256629
33GRK71.24426126
34CAMK11.22357722
35AKT31.17847497
36TNIK1.15184757
37CAMK2D1.12573548
38CCNB11.07779083
39CAMK41.06717658
40BRD41.00928598
41STK381.00385743
42BCR0.97579045
43UHMK10.91635520
44DAPK20.88713068
45MKNK10.86353826
46TIE10.83537207
47MINK10.83213212
48TRIM280.81133695
49NUAK10.80789530
50ROCK10.80655748
51PRKAA10.80448123
52CAMKK20.73656264
53PAK60.73118529
54CAMK2B0.69189186
55WEE10.68559048
56NTRK20.68512997
57PKN10.66805373
58CDC70.64861787
59SGK20.63008928
60MAP2K70.62662911
61PRKCG0.62375048
62PRKAA20.61074263
63WNK10.59145717
64CDK30.58767999
65PTK2B0.58479830
66ADRBK10.57510298
67ZAK0.56966991
68MUSK0.55858106
69MAP3K70.55656605
70PRKG10.53812478
71PRKACA0.53718630
72PHKG20.53226898
73PHKG10.53226898
74NEK90.52715003
75PRKD10.52608169
76OXSR10.50731860
77FGFR20.49183472
78RPS6KA30.48002129
79CDK50.47130988
80ROCK20.46684912
81ATM0.46280217
82STK40.44419298
83DYRK1A0.43190566
84STK110.43008233
85CSNK1G10.42987268
86NLK0.42313264
87PRKACB0.41434845
88STK390.41385675
89NEK10.40580025
90CAMK1G0.39174334
91SGK2230.38055085
92SGK4940.38055085
93PIK3CG0.37573013
94SGK10.37305942
95MAPK150.36343217
96ADRBK20.34941780
97CSNK1G20.34683390
98PRKACG0.34636956
99LATS20.34434836
100TTK0.33810143

Predicted pathways (KEGG)

RankGene SetZ-score
1Dilated cardiomyopathy_Homo sapiens_hsa054143.41777448
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.16327650
3Cardiac muscle contraction_Homo sapiens_hsa042602.96708631
4Nicotine addiction_Homo sapiens_hsa050332.66651130
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.44956896
6Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.23489115
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.23087135
8Taste transduction_Homo sapiens_hsa047422.10507655
9Circadian entrainment_Homo sapiens_hsa047132.09781329
10Propanoate metabolism_Homo sapiens_hsa006402.05685238
11Morphine addiction_Homo sapiens_hsa050322.03431508
12GABAergic synapse_Homo sapiens_hsa047271.92993947
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.90827149
14Butanoate metabolism_Homo sapiens_hsa006501.81747475
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.79285032
16Insulin secretion_Homo sapiens_hsa049111.78109195
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.74832445
18Renin secretion_Homo sapiens_hsa049241.74776623
19Glutamatergic synapse_Homo sapiens_hsa047241.63988288
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.58242607
21Calcium signaling pathway_Homo sapiens_hsa040201.57853545
22Circadian rhythm_Homo sapiens_hsa047101.56691596
23cGMP-PKG signaling pathway_Homo sapiens_hsa040221.50558846
24Salivary secretion_Homo sapiens_hsa049701.48619475
25Phototransduction_Homo sapiens_hsa047441.45822875
26cAMP signaling pathway_Homo sapiens_hsa040241.35097143
27Amphetamine addiction_Homo sapiens_hsa050311.32014489
28Olfactory transduction_Homo sapiens_hsa047401.19768098
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.19349368
30Oxytocin signaling pathway_Homo sapiens_hsa049211.18470384
31Gastric acid secretion_Homo sapiens_hsa049711.14057839
32Dopaminergic synapse_Homo sapiens_hsa047281.09008788
33Vascular smooth muscle contraction_Homo sapiens_hsa042701.07053733
34Regulation of autophagy_Homo sapiens_hsa041401.06019426
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03561065
36Fanconi anemia pathway_Homo sapiens_hsa034601.02520420
37Serotonergic synapse_Homo sapiens_hsa047260.99566808
38Cocaine addiction_Homo sapiens_hsa050300.99094073
39Cholinergic synapse_Homo sapiens_hsa047250.98398800
40Fatty acid metabolism_Homo sapiens_hsa012120.96548054
41Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.96488405
42Oocyte meiosis_Homo sapiens_hsa041140.95445873
43Parkinsons disease_Homo sapiens_hsa050120.93849789
44Fatty acid degradation_Homo sapiens_hsa000710.93591450
45Non-homologous end-joining_Homo sapiens_hsa034500.93234062
46Pancreatic secretion_Homo sapiens_hsa049720.92920300
47Aldosterone synthesis and secretion_Homo sapiens_hsa049250.91780446
48Tryptophan metabolism_Homo sapiens_hsa003800.91652821
49beta-Alanine metabolism_Homo sapiens_hsa004100.87360020
50Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84345577
51Homologous recombination_Homo sapiens_hsa034400.84332986
52Gap junction_Homo sapiens_hsa045400.84146748
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81514410
54Huntingtons disease_Homo sapiens_hsa050160.81059007
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80022935
56Pyruvate metabolism_Homo sapiens_hsa006200.79241263
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.79161531
58Long-term potentiation_Homo sapiens_hsa047200.77449253
59Oxidative phosphorylation_Homo sapiens_hsa001900.73130183
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.71020386
61Lysine degradation_Homo sapiens_hsa003100.70544862
62Hedgehog signaling pathway_Homo sapiens_hsa043400.70293731
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68896329
64Ovarian steroidogenesis_Homo sapiens_hsa049130.68499856
65Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68239573
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67554492
67ABC transporters_Homo sapiens_hsa020100.65972958
68Fatty acid biosynthesis_Homo sapiens_hsa000610.65729979
69Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.65398254
70Linoleic acid metabolism_Homo sapiens_hsa005910.65237948
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65076905
72Alzheimers disease_Homo sapiens_hsa050100.64514666
73Synaptic vesicle cycle_Homo sapiens_hsa047210.61433683
74Purine metabolism_Homo sapiens_hsa002300.61020673
75Long-term depression_Homo sapiens_hsa047300.60409393
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55314933
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54640292
78Dorso-ventral axis formation_Homo sapiens_hsa043200.52597489
79Arginine and proline metabolism_Homo sapiens_hsa003300.50666579
80PPAR signaling pathway_Homo sapiens_hsa033200.50419539
81Thyroid hormone synthesis_Homo sapiens_hsa049180.50345004
82Tight junction_Homo sapiens_hsa045300.50311072
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49521223
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49060059
85Melanogenesis_Homo sapiens_hsa049160.48043623
86Caffeine metabolism_Homo sapiens_hsa002320.47786439
87Alcoholism_Homo sapiens_hsa050340.47210765
88Glucagon signaling pathway_Homo sapiens_hsa049220.47082630
89Bile secretion_Homo sapiens_hsa049760.46399311
90Ether lipid metabolism_Homo sapiens_hsa005650.46049496
91Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.46010928
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.45644057
93Hippo signaling pathway_Homo sapiens_hsa043900.43766159
94Peroxisome_Homo sapiens_hsa041460.42771797
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42273175
96Adherens junction_Homo sapiens_hsa045200.39690586
97Basal cell carcinoma_Homo sapiens_hsa052170.39529160
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37667497
99Type II diabetes mellitus_Homo sapiens_hsa049300.37622672
100Phenylalanine metabolism_Homo sapiens_hsa003600.36759721

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