DPRXP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1NAD biosynthetic process (GO:0009435)8.53369283
2macroautophagy (GO:0016236)7.89982216
3N-acetylglucosamine metabolic process (GO:0006044)7.24421941
4pyridine nucleotide biosynthetic process (GO:0019363)6.90406748
5nicotinamide nucleotide biosynthetic process (GO:0019359)6.90406748
6detection of bacterium (GO:0016045)6.42807435
7membrane repolarization during cardiac muscle cell action potential (GO:0086013)6.09521487
8regulation of natural killer cell differentiation (GO:0032823)6.01276049
9tRNA methylation (GO:0030488)5.96611623
10detection of other organism (GO:0098543)5.94589387
11membrane repolarization during action potential (GO:0086011)5.77550852
12positive regulation of histone deacetylation (GO:0031065)5.62903922
13behavioral response to nicotine (GO:0035095)5.58522077
14male sex determination (GO:0030238)5.17709863
15pyridine-containing compound biosynthetic process (GO:0072525)5.11388188
16myoblast migration (GO:0051451)5.08258921
17cellular response to pH (GO:0071467)5.02356300
18potassium ion export (GO:0071435)4.93131519
19regulation of histone phosphorylation (GO:0033127)4.71976755
20type B pancreatic cell development (GO:0003323)4.63642155
21detection of biotic stimulus (GO:0009595)4.47964272
22glucosamine-containing compound metabolic process (GO:1901071)4.33312626
23toxin metabolic process (GO:0009404)4.26348551
24meiotic chromosome segregation (GO:0045132)4.24905934
25sterol catabolic process (GO:0016127)4.23602621
26cholesterol catabolic process (GO:0006707)4.23602621
27somite development (GO:0061053)4.20988759
28NAD metabolic process (GO:0019674)4.18011887
29anterior/posterior axis specification, embryo (GO:0008595)4.15962268
30negative regulation of interleukin-1 beta production (GO:0032691)4.09063989
31L-fucose catabolic process (GO:0042355)4.08408880
32fucose catabolic process (GO:0019317)4.08408880
33L-fucose metabolic process (GO:0042354)4.08408880
34interkinetic nuclear migration (GO:0022027)4.01787600
35platelet dense granule organization (GO:0060155)4.01628839
36positive regulation of protein deacetylation (GO:0090312)3.96993100
37detection of external biotic stimulus (GO:0098581)3.93683376
38negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.92762211
39keratan sulfate biosynthetic process (GO:0018146)3.91341697
40mitochondrial calcium ion transport (GO:0006851)3.69388385
41sex determination (GO:0007530)3.59625264
42sulfate transmembrane transport (GO:1902358)3.59259418
43membrane repolarization (GO:0086009)3.54476844
44sulfate transport (GO:0008272)3.54246633
45sulfur amino acid metabolic process (GO:0000096)3.53696460
46regulation of stem cell maintenance (GO:2000036)3.51747433
47regulation of histone deacetylation (GO:0031063)3.47778050
48negative regulation of interleukin-1 production (GO:0032692)3.47163117
49regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.46296993
50regulation of mitotic spindle checkpoint (GO:1903504)3.46296993
51dorsal/ventral neural tube patterning (GO:0021904)3.44281414
52protein localization to microtubule cytoskeleton (GO:0072698)3.43984605
53exocrine pancreas development (GO:0031017)3.38226636
54positive regulation of histone acetylation (GO:0035066)3.37550581
55adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189)3.33478510
56positive regulation of triglyceride biosynthetic process (GO:0010867)3.30802580
57regulation of cholesterol homeostasis (GO:2000188)3.30165819
58embryonic digestive tract morphogenesis (GO:0048557)3.29639011
59glandular epithelial cell development (GO:0002068)3.24986116
60histone-serine phosphorylation (GO:0035404)3.24521367
61response to pH (GO:0009268)3.24502536
62cAMP biosynthetic process (GO:0006171)3.18262751
63behavioral response to ethanol (GO:0048149)3.18024853
64protein K6-linked ubiquitination (GO:0085020)3.09458878
65positive regulation of peptidyl-lysine acetylation (GO:2000758)3.06539218
66positive regulation of protein acetylation (GO:1901985)3.06539218
67negative regulation of lymphocyte differentiation (GO:0045620)3.06089965
68protein sumoylation (GO:0016925)3.05500910
69positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.04404975
70keratan sulfate metabolic process (GO:0042339)3.01426123
71regulation of triglyceride biosynthetic process (GO:0010866)2.99691341
72regulation of natural killer cell activation (GO:0032814)2.97686457
73melanocyte differentiation (GO:0030318)2.97366623
74thalamus development (GO:0021794)2.96450562
75response to misfolded protein (GO:0051788)2.94947325
76hematopoietic stem cell differentiation (GO:0060218)2.94912419
77melanosome localization (GO:0032400)2.93485780
78regulation of interferon-beta biosynthetic process (GO:0045357)2.92529558
79positive regulation of steroid hormone secretion (GO:2000833)2.91380884
80negative regulation of mast cell activation (GO:0033004)2.90581069
81fucose metabolic process (GO:0006004)2.89685947
82sulfur compound catabolic process (GO:0044273)2.84458328
83mitochondrial calcium ion homeostasis (GO:0051560)2.84150155
84pigment granule localization (GO:0051875)2.82430362
85pigment cell differentiation (GO:0050931)2.81694149
86protein localization to cytoskeleton (GO:0044380)2.81372489
87negative regulation of smooth muscle cell differentiation (GO:0051151)2.81288026
88response to pheromone (GO:0019236)2.76388053
89positive regulation of chemokine biosynthetic process (GO:0045080)2.76033701
90amino sugar metabolic process (GO:0006040)2.72294421
91regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.70127219
92polyol catabolic process (GO:0046174)2.66827328
93regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)2.66440602
94regulation of heart rate by cardiac conduction (GO:0086091)2.60501593
95sulfur compound transport (GO:0072348)2.59862789
96negative regulation of transcription regulatory region DNA binding (GO:2000678)2.59304527
97positive regulation of neuroblast proliferation (GO:0002052)2.56899060
98negative regulation of osteoclast differentiation (GO:0045671)2.56573764
99retinal cone cell development (GO:0046549)2.54913224
100sulfur amino acid catabolic process (GO:0000098)11.4296248

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.26045074
2RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.05236480
3ZNF263_19887448_ChIP-Seq_K562_Human5.01661449
4ZNF274_21170338_ChIP-Seq_K562_Hela4.50264979
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.08827765
6NOTCH1_21737748_ChIP-Seq_TLL_Human3.68691233
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.57050413
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.19882284
9TP63_19390658_ChIP-ChIP_HaCaT_Human2.70335859
10ESR1_20079471_ChIP-ChIP_T-47D_Human2.47287308
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.14135294
12EGR1_23403033_ChIP-Seq_LIVER_Mouse2.00482032
13MYC_18940864_ChIP-ChIP_HL60_Human1.88038946
14TAF2_19829295_ChIP-Seq_ESCs_Human1.83304544
15SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.74161613
16YY1_22570637_ChIP-Seq_MALME-3M_Human1.72515132
17IRF8_22096565_ChIP-ChIP_GC-B_Human1.70930856
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.69101753
19ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67048179
20EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.65250202
21GATA3_21878914_ChIP-Seq_MCF-7_Human1.64618580
22TP53_22573176_ChIP-Seq_HFKS_Human1.60797794
23GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.60178796
24AHR_22903824_ChIP-Seq_MCF-7_Human1.59410447
25AR_20517297_ChIP-Seq_VCAP_Human1.57303493
26NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.55974376
27VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.49606554
28STAT3_1855785_ChIP-Seq_MESCs_Mouse1.48714165
29HOXB7_26014856_ChIP-Seq_BT474_Human1.44637752
30RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.43642413
31ESR1_15608294_ChIP-ChIP_MCF-7_Human1.39824440
32IGF1R_20145208_ChIP-Seq_DFB_Human1.32025269
33STAT3_23295773_ChIP-Seq_U87_Human1.31471119
34NANOG_20526341_ChIP-Seq_ESCs_Human1.28163047
35MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27321685
36VDR_22108803_ChIP-Seq_LS180_Human1.27089309
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25040128
38DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.24737490
39PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.24614765
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.20998617
41GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.20456104
42GATA3_26560356_Chip-Seq_TH2_Human1.20164008
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19426241
44MYC_19829295_ChIP-Seq_ESCs_Human1.16919679
45SOX2_19829295_ChIP-Seq_ESCs_Human1.12892129
46NANOG_19829295_ChIP-Seq_ESCs_Human1.12892129
47SPI1_20517297_ChIP-Seq_HL60_Human1.12568358
48FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12042226
49FOXA1_25329375_ChIP-Seq_VCAP_Human1.12042226
50* CTCF_20526341_ChIP-Seq_ESCs_Human1.10249928
51RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.09386973
52BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.08751199
53GABP_17652178_ChIP-ChIP_JURKAT_Human1.07938433
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.07727884
55TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.06546738
56NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05240090
57SOX2_21211035_ChIP-Seq_LN229_Human1.04007439
58TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03781808
59ELF1_20517297_ChIP-Seq_JURKAT_Human1.03516027
60STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.03428188
61ARNT_22903824_ChIP-Seq_MCF-7_Human1.02641409
62ETS1_20019798_ChIP-Seq_JURKAT_Human1.00585486
63EST1_17652178_ChIP-ChIP_JURKAT_Human1.00547980
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00477089
65TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00314024
66FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00205195
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.00043572
68GATA1_19941826_ChIP-Seq_K562_Human0.96807356
69PHF8_20622854_ChIP-Seq_HELA_Human0.96416393
70TTF2_22483619_ChIP-Seq_HELA_Human0.96067354
71SPI1_23547873_ChIP-Seq_NB4_Human0.95609628
72E2F7_22180533_ChIP-Seq_HELA_Human0.95170421
73ESR1_21235772_ChIP-Seq_MCF-7_Human0.93527006
74VDR_23849224_ChIP-Seq_CD4+_Human0.92107829
75FOXA1_21572438_ChIP-Seq_LNCaP_Human0.90329133
76RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90316617
77ERA_21632823_ChIP-Seq_H3396_Human0.90120304
78AR_25329375_ChIP-Seq_VCAP_Human0.89360591
79ELF5_23300383_ChIP-Seq_T47D_Human0.88320647
80TCF4_22108803_ChIP-Seq_LS180_Human0.88092964
81STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.86659530
82SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.86406903
83FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86396876
84PADI4_21655091_ChIP-ChIP_MCF-7_Human0.85340921
85* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.85179339
86P53_21459846_ChIP-Seq_SAOS-2_Human0.84786622
87STAT1_20625510_ChIP-Seq_HELA_Human0.82941327
88SRF_21415370_ChIP-Seq_HL-1_Mouse0.81261763
89EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.81200722
90ERG_20517297_ChIP-Seq_VCAP_Human0.80101229
91BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.79780015
92OCT4_19829295_ChIP-Seq_ESCs_Human0.79026254
93GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.78838452
94TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78773427
95PPARA_22158963_ChIP-Seq_LIVER_Mouse0.78771814
96E2F1_20622854_ChIP-Seq_HELA_Human0.78085553
97EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.77988041
98BCAT_22108803_ChIP-Seq_LS180_Human0.77802042
99ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.76231312
100HTT_18923047_ChIP-ChIP_STHdh_Human0.76005891

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008004_abnormal_stomach_pH6.26895106
2MP0008875_abnormal_xenobiotic_pharmacok4.10078757
3MP0001485_abnormal_pinna_reflex3.99979739
4MP0004019_abnormal_vitamin_homeostasis3.87987803
5MP0009840_abnormal_foam_cell3.75077055
6MP0005377_hearing/vestibular/ear_phenot3.43368267
7MP0003878_abnormal_ear_physiology3.43368267
8MP0002877_abnormal_melanocyte_morpholog3.34437009
9MP0000013_abnormal_adipose_tissue3.23892421
10MP0003075_altered_response_to3.10397534
11MP0003011_delayed_dark_adaptation2.85858551
12MP0002102_abnormal_ear_morphology2.77916456
13MP0002254_reproductive_system_inflammat2.64690104
14MP0005165_increased_susceptibility_to2.32674668
15MP0005083_abnormal_biliary_tract2.28554125
16MP0000003_abnormal_adipose_tissue2.25243310
17MP0003195_calcinosis2.22363127
18MP0003283_abnormal_digestive_organ2.21487039
19MP0004742_abnormal_vestibular_system1.97745078
20MP0003567_abnormal_fetal_cardiomyocyte1.95433703
21MP0004885_abnormal_endolymph1.94494085
22MP0005076_abnormal_cell_differentiation1.92428268
23MP0000371_diluted_coat_color1.89108488
24MP0003638_abnormal_response/metabolism_1.88231589
25MP0000604_amyloidosis1.86874677
26MP0000767_abnormal_smooth_muscle1.82424492
27MP0000372_irregular_coat_pigmentation1.56579071
28MP0008961_abnormal_basal_metabolism1.55812195
29MP0010030_abnormal_orbit_morphology1.55638420
30MP0001873_stomach_inflammation1.51175775
31MP0003221_abnormal_cardiomyocyte_apopto1.47227331
32MP0005646_abnormal_pituitary_gland1.46873970
33MP0009115_abnormal_fat_cell1.45951241
34MP0000470_abnormal_stomach_morphology1.45841379
35MP0002933_joint_inflammation1.44212280
36MP0005551_abnormal_eye_electrophysiolog1.39169516
37MP0003329_amyloid_beta_deposits1.36573376
38MP0003191_abnormal_cellular_cholesterol1.36380795
39MP0000685_abnormal_immune_system1.35849516
40MP0005167_abnormal_blood-brain_barrier1.31349524
41MP0001663_abnormal_digestive_system1.25291998
42MP0006082_CNS_inflammation1.16509151
43MP0005381_digestive/alimentary_phenotyp1.09873577
44MP0002234_abnormal_pharynx_morphology1.04774922
45MP0002148_abnormal_hypersensitivity_rea1.01139334
46MP0009384_cardiac_valve_regurgitation1.00942448
47MP0003718_maternal_effect0.99802194
48MP0004215_abnormal_myocardial_fiber0.98556638
49MP0003693_abnormal_embryo_hatching0.97824078
50MP0003646_muscle_fatigue0.97087932
51MP0001790_abnormal_immune_system0.91283544
52MP0005387_immune_system_phenotype0.91283544
53MP0005023_abnormal_wound_healing0.89633932
54MP0001502_abnormal_circadian_rhythm0.87147039
55MP0009785_altered_susceptibility_to0.85163648
56MP0001545_abnormal_hematopoietic_system0.84350369
57MP0005397_hematopoietic_system_phenotyp0.84350369
58MP0003959_abnormal_lean_body0.82231300
59MP0005075_abnormal_melanosome_morpholog0.81032941
60MP0003938_abnormal_ear_development0.79715447
61MP0009278_abnormal_bone_marrow0.79621820
62MP0004130_abnormal_muscle_cell0.78381420
63MP0005375_adipose_tissue_phenotype0.77720078
64MP0001853_heart_inflammation0.74341235
65MP0010329_abnormal_lipoprotein_level0.73019782
66MP0008995_early_reproductive_senescence0.72943668
67MP0003786_premature_aging0.70677424
68MP0001324_abnormal_eye_pigmentation0.70146311
69MP0000343_altered_response_to0.66664275
70MP0001765_abnormal_ion_homeostasis0.65835242
71MP0001800_abnormal_humoral_immune0.65286408
72MP0001944_abnormal_pancreas_morphology0.63385468
73MP0003315_abnormal_perineum_morphology0.63342913
74MP0002277_abnormal_respiratory_mucosa0.62862875
75MP0002998_abnormal_bone_remodeling0.61943220
76MP0005334_abnormal_fat_pad0.61402914
77MP0009046_muscle_twitch0.60655061
78MP0001191_abnormal_skin_condition0.59522643
79MP0005253_abnormal_eye_physiology0.58970453
80MP0002452_abnormal_antigen_presenting0.58791362
81MP0002396_abnormal_hematopoietic_system0.58658955
82MP0005464_abnormal_platelet_physiology0.57700353
83MP0009250_abnormal_appendicular_skeleto0.57003332
84MP0001486_abnormal_startle_reflex0.56122648
85MP0002419_abnormal_innate_immunity0.55693191
86MP0005166_decreased_susceptibility_to0.54149320
87MP0005448_abnormal_energy_balance0.52187692
88MP0005164_abnormal_response_to0.51708178
89MP0002135_abnormal_kidney_morphology0.51187265
90MP0005025_abnormal_response_to0.51087053
91MP0001533_abnormal_skeleton_physiology0.50117513
92MP0002282_abnormal_trachea_morphology0.49914416
93MP0004510_myositis0.49709167
94MP0002736_abnormal_nociception_after0.49571594
95MP0002118_abnormal_lipid_homeostasis0.49467900
96MP0002075_abnormal_coat/hair_pigmentati0.48874145
97MP0003828_pulmonary_edema0.47454412
98MP0001851_eye_inflammation0.47448641
99MP0002723_abnormal_immune_serum0.47290736
100MP0003953_abnormal_hormone_level0.47155891

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)7.93677706
2Recurrent corneal erosions (HP:0000495)7.61769131
3Attenuation of retinal blood vessels (HP:0007843)5.93345176
4Concave nail (HP:0001598)5.86430121
5Renal cortical cysts (HP:0000803)4.84431877
6Generalized hypopigmentation of hair (HP:0011358)4.75287023
7Abnormality of the renal cortex (HP:0011035)4.35327598
8Abnormal hair laboratory examination (HP:0003328)4.29009443
9Microvesicular hepatic steatosis (HP:0001414)4.14624169
10Breast hypoplasia (HP:0003187)4.10742441
11Prominent supraorbital ridges (HP:0000336)3.95262874
12Ventricular fibrillation (HP:0001663)3.70135994
13Optic disc pallor (HP:0000543)3.63247938
14Patellar aplasia (HP:0006443)3.60842732
15Oligodactyly (hands) (HP:0001180)3.51373306
16Nausea (HP:0002018)3.50560007
17Tracheomalacia (HP:0002779)3.33826699
18Fair hair (HP:0002286)3.33660603
19Prolonged QT interval (HP:0001657)3.28585730
20Aplasia/Hypoplasia of the patella (HP:0006498)3.27813432
21Delayed CNS myelination (HP:0002188)3.26204249
22Bronchomalacia (HP:0002780)3.24458648
23Abnormality of the labia minora (HP:0012880)3.21254567
24Hypoplasia of the fovea (HP:0007750)3.07048507
25Aplasia/Hypoplasia of the fovea (HP:0008060)3.07048507
26Hypoplastic labia majora (HP:0000059)3.06344442
27Cleft eyelid (HP:0000625)2.88797330
28Abnormality of the labia majora (HP:0012881)2.84943640
29Abnormality of alanine metabolism (HP:0010916)2.81424908
30Hyperalaninemia (HP:0003348)2.81424908
31Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.81424908
32Metabolic alkalosis (HP:0200114)2.79210927
33Vacuolated lymphocytes (HP:0001922)2.74562088
34Global brain atrophy (HP:0002283)2.72592670
35Clitoromegaly (HP:0000057)2.68709434
36Abnormality of midbrain morphology (HP:0002418)2.61074631
37Molar tooth sign on MRI (HP:0002419)2.61074631
38Wrist flexion contracture (HP:0001239)2.60234437
39Conjugated hyperbilirubinemia (HP:0002908)2.59377951
403-Methylglutaconic aciduria (HP:0003535)2.52875092
41True hermaphroditism (HP:0010459)2.49446833
42Enlarged penis (HP:0000040)2.49284016
43Abnormal number of erythroid precursors (HP:0012131)2.48386688
44Cheilitis (HP:0100825)2.48363531
45Hypoglycemic coma (HP:0001325)2.47525940
46Pancreatic cysts (HP:0001737)2.46851314
47Corneal erosion (HP:0200020)2.43580569
48Abnormality of the labia (HP:0000058)2.40436934
49Supernumerary spleens (HP:0009799)2.36426434
50Abnormality of the fovea (HP:0000493)2.32510425
51Recurrent cutaneous fungal infections (HP:0011370)2.30604854
52Chronic mucocutaneous candidiasis (HP:0002728)2.30604854
53Abnormality of the renal medulla (HP:0100957)2.30516888
54Death in childhood (HP:0003819)2.22605778
55Abnormality of renin-angiotensin system (HP:0000847)2.22129296
56Slender long bone (HP:0003100)2.21972128
57Acute encephalopathy (HP:0006846)2.19304943
58Keratoconus (HP:0000563)2.18982490
59Increased corneal curvature (HP:0100692)2.18982490
6011 pairs of ribs (HP:0000878)2.17371894
61Thrombocytosis (HP:0001894)2.16076020
62Oligodactyly (HP:0012165)2.15228632
63Congenital stationary night blindness (HP:0007642)2.14309817
64Abnormality of the clitoris (HP:0000056)2.12803223
65Decreased circulating renin level (HP:0003351)2.12403340
66Metaphyseal irregularity (HP:0003025)2.08479463
67Pancreatic fibrosis (HP:0100732)2.08243389
68Long nose (HP:0003189)2.07339668
69Brittle hair (HP:0002299)2.02157064
70Elevated erythrocyte sedimentation rate (HP:0003565)2.01515508
71Photophobia (HP:0000613)1.99030408
72Nephronophthisis (HP:0000090)1.97616231
73Aplasia/Hypoplasia of the sacrum (HP:0008517)1.95738660
74Tubulointerstitial fibrosis (HP:0005576)1.93420426
75Generalized aminoaciduria (HP:0002909)1.90150901
76Aplasia/Hypoplasia of the macula (HP:0008059)1.88581211
77Abnormality of cells of the erythroid lineage (HP:0012130)1.86419030
78Furrowed tongue (HP:0000221)1.82977577
79Partial agenesis of the corpus callosum (HP:0001338)1.82004356
80Hyperaldosteronism (HP:0000859)1.80834664
81Alkalosis (HP:0001948)1.77977395
82Patent foramen ovale (HP:0001655)1.76293804
83Renal salt wasting (HP:0000127)1.76122114
84Abnormality of transition element cation homeostasis (HP:0011030)1.75847389
85Aplasia/Hypoplasia affecting the retina (HP:0008061)1.75498152
86Hypoplastic iliac wings (HP:0002866)1.75136443
87Labial hypoplasia (HP:0000066)1.74540911
88Degeneration of anterior horn cells (HP:0002398)1.74407291
89Abnormality of the anterior horn cell (HP:0006802)1.74407291
90Abnormal EKG (HP:0003115)1.74319469
91Polyuria (HP:0000103)1.72462959
92Hypomagnesemia (HP:0002917)1.71691690
93Female pseudohermaphroditism (HP:0010458)1.70802767
94Spastic tetraparesis (HP:0001285)1.69117880
95Corneal dystrophy (HP:0001131)1.67755900
96Abnormality of chromosome segregation (HP:0002916)1.67319985
97Capillary hemangiomas (HP:0005306)1.66291201
98Congenital sensorineural hearing impairment (HP:0008527)1.64903264
99Hypoplastic female external genitalia (HP:0012815)1.64025190
100Ocular albinism (HP:0001107)1.63842926

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK3.03816342
2TLK12.90507409
3SIK32.17210201
4INSRR14.2348104
5CASK1.99057915
6TRIM281.83849274
7ERN11.69730375
8VRK11.65263793
9STK241.39095575
10ACVR1B1.34289186
11KIT1.33295690
12BMPR1B1.13339939
13TNK21.10361161
14MST41.08988567
15STK391.02457536
16RPS6KA51.02347665
17VRK21.01380101
18BCKDK0.94215981
19PRKCQ0.89332696
20PIM10.87107966
21DAPK20.87009703
22PAK30.86692448
23ADRBK20.84906715
24TEC0.82634691
25JAK30.81994146
26PKN10.81157324
27WNK40.74989945
28TGFBR10.74463376
29KDR0.72961293
30FLT30.69929535
31CCNB10.68255829
32PTK60.66664778
33IKBKB0.59917100
34CAMK1D0.59745279
35TSSK60.57278126
36CHUK0.55836472
37FRK0.55790464
38OXSR10.55713261
39CDK120.52794522
40GRK70.51060239
41CHEK20.50911448
42MELK0.49803570
43WNK30.47928546
44PRKAA20.47843712
45MAP2K20.47499953
46MUSK0.47278360
47TYK20.46644336
48GRK10.45944464
49WEE10.45126614
50PRKCI0.44800190
51ABL20.42071566
52CSNK1E0.41663149
53MARK30.39927816
54PHKG10.39457759
55PHKG20.39457759
56ITK0.38965566
57BLK0.38846606
58PINK10.38680962
59MKNK10.37909803
60MAP3K20.37088008
61KSR10.35917021
62MAPK90.35483075
63MAP4K20.35034995
64ADRBK10.33325943
65CAMK10.32453549
66SYK0.32032936
67ILK0.31541051
68CDK40.30929058
69BRSK20.30036776
70MAP3K50.29496704
71BTK0.29117540
72MAP4K10.28479749
73TRPM70.28454107
74PRKCA0.27242847
75PRKCD0.26954757
76TGFBR20.26651616
77CSNK2A10.26308372
78STK30.26012852
79TBK10.26007821
80MKNK20.25176193
81MAP3K80.25120079
82CAMKK20.23630348
83LYN0.22774179
84STK100.22770111
85MATK0.22306565
86LRRK20.22209254
87RPS6KA60.21707084
88ZAP700.20799134
89MAPK140.20564373
90PDK10.19741339
91PRKCG0.19487938
92MAPK30.19072653
93PRKCZ0.19032870
94NME20.18815368
95RIPK40.18404607
96TAOK30.17842783
97ROCK10.16604758
98MAP2K10.16370179
99SIK20.15250939
100CSF1R0.15001491

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005336.41181721
2Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007603.78766764
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.57748516
4Caffeine metabolism_Homo sapiens_hsa002322.50273815
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.34922382
6Taurine and hypotaurine metabolism_Homo sapiens_hsa0043010.8361656
7One carbon pool by folate_Homo sapiens_hsa006701.95312787
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.63265281
9Base excision repair_Homo sapiens_hsa034101.50996271
10Selenocompound metabolism_Homo sapiens_hsa004501.46923002
11Mineral absorption_Homo sapiens_hsa049781.37022067
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.36540319
13Nitrogen metabolism_Homo sapiens_hsa009101.35004967
14Butanoate metabolism_Homo sapiens_hsa006501.18921246
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01244886
16Homologous recombination_Homo sapiens_hsa034400.97158101
17Chemical carcinogenesis_Homo sapiens_hsa052040.93910324
18Dorso-ventral axis formation_Homo sapiens_hsa043200.89351988
19Systemic lupus erythematosus_Homo sapiens_hsa053220.88341260
20ABC transporters_Homo sapiens_hsa020100.84636946
21Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.83035813
22Intestinal immune network for IgA production_Homo sapiens_hsa046720.79883165
23Arginine biosynthesis_Homo sapiens_hsa002200.76656750
24Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74770019
25Histidine metabolism_Homo sapiens_hsa003400.72401411
26Vascular smooth muscle contraction_Homo sapiens_hsa042700.71230838
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64924264
28Fatty acid biosynthesis_Homo sapiens_hsa000610.64287933
29Staphylococcus aureus infection_Homo sapiens_hsa051500.63419453
30Ether lipid metabolism_Homo sapiens_hsa005650.62743649
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.62415732
32Prostate cancer_Homo sapiens_hsa052150.61369395
33Type I diabetes mellitus_Homo sapiens_hsa049400.59514250
34Asthma_Homo sapiens_hsa053100.58431757
35Linoleic acid metabolism_Homo sapiens_hsa005910.58177858
36Fanconi anemia pathway_Homo sapiens_hsa034600.57759998
37Alcoholism_Homo sapiens_hsa050340.57617523
38Proteasome_Homo sapiens_hsa030500.56412058
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55598063
40Spliceosome_Homo sapiens_hsa030400.55088600
41Tryptophan metabolism_Homo sapiens_hsa003800.54889426
42Regulation of autophagy_Homo sapiens_hsa041400.53125992
43Other glycan degradation_Homo sapiens_hsa005110.52708894
44RNA polymerase_Homo sapiens_hsa030200.50412852
45Oxidative phosphorylation_Homo sapiens_hsa001900.48338218
46Basal cell carcinoma_Homo sapiens_hsa052170.46499929
47Cell cycle_Homo sapiens_hsa041100.45880232
48Ovarian steroidogenesis_Homo sapiens_hsa049130.45090153
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45060117
50Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.43851210
51Phototransduction_Homo sapiens_hsa047440.43276792
52Insulin secretion_Homo sapiens_hsa049110.42964470
53Type II diabetes mellitus_Homo sapiens_hsa049300.42684227
54Leishmaniasis_Homo sapiens_hsa051400.42494814
55Bile secretion_Homo sapiens_hsa049760.41923804
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41628245
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41530608
58Adipocytokine signaling pathway_Homo sapiens_hsa049200.40964864
59TGF-beta signaling pathway_Homo sapiens_hsa043500.40226940
60Lysosome_Homo sapiens_hsa041420.39308276
61Bladder cancer_Homo sapiens_hsa052190.39261551
62Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37849732
63Tuberculosis_Homo sapiens_hsa051520.36208929
64Steroid hormone biosynthesis_Homo sapiens_hsa001400.35276305
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33996570
66Osteoclast differentiation_Homo sapiens_hsa043800.33599409
67HIF-1 signaling pathway_Homo sapiens_hsa040660.32046285
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31326028
69Calcium signaling pathway_Homo sapiens_hsa040200.31246902
70Glutathione metabolism_Homo sapiens_hsa004800.31203682
71Rheumatoid arthritis_Homo sapiens_hsa053230.29600710
72Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.29193183
73Thyroid cancer_Homo sapiens_hsa052160.26977069
74NOD-like receptor signaling pathway_Homo sapiens_hsa046210.23101712
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.23072106
76Shigellosis_Homo sapiens_hsa051310.22759541
77Metabolic pathways_Homo sapiens_hsa011000.22301416
78Salivary secretion_Homo sapiens_hsa049700.21963741
79Toxoplasmosis_Homo sapiens_hsa051450.21080071
80Morphine addiction_Homo sapiens_hsa050320.20752567
81Alzheimers disease_Homo sapiens_hsa050100.19606563
82Sphingolipid metabolism_Homo sapiens_hsa006000.18607184
83Primary immunodeficiency_Homo sapiens_hsa053400.18464976
84Circadian entrainment_Homo sapiens_hsa047130.18463727
85Hematopoietic cell lineage_Homo sapiens_hsa046400.18462659
86Cardiac muscle contraction_Homo sapiens_hsa042600.18113294
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.18032774
88Retinol metabolism_Homo sapiens_hsa008300.17408017
89Antigen processing and presentation_Homo sapiens_hsa046120.17228790
90Nicotine addiction_Homo sapiens_hsa050330.16321637
91PPAR signaling pathway_Homo sapiens_hsa033200.16166794
92Olfactory transduction_Homo sapiens_hsa047400.15854312
93DNA replication_Homo sapiens_hsa030300.14075998
94Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.12333449
95Pyrimidine metabolism_Homo sapiens_hsa002400.11377851
96Huntingtons disease_Homo sapiens_hsa050160.10752493
97Gastric acid secretion_Homo sapiens_hsa049710.10703535
98Herpes simplex infection_Homo sapiens_hsa051680.10450910
99Peroxisome_Homo sapiens_hsa041460.10206756
100Propanoate metabolism_Homo sapiens_hsa006400.10117364

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