DPRX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the DPRX homeobox gene family. Evidence of mRNA expression has not yet been found for this gene. Multiple, related processed pseudogenes have been found which are thought to reflect expression of this gene in the germ line or embryonic cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1transcription from mitochondrial promoter (GO:0006390)8.36209316
2rRNA modification (GO:0000154)7.39080993
3chaperone-mediated protein transport (GO:0072321)6.99759571
4autophagic vacuole assembly (GO:0000045)6.92932945
5regulation of G0 to G1 transition (GO:0070316)6.55601011
6ribosomal small subunit biogenesis (GO:0042274)6.47513976
7very-low-density lipoprotein particle assembly (GO:0034379)6.44567649
8rRNA methylation (GO:0031167)6.09391580
9regulation of protein homooligomerization (GO:0032462)5.53159235
10attachment of spindle microtubules to kinetochore (GO:0008608)5.27663559
11regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.22459901
12skeletal muscle tissue regeneration (GO:0043403)4.88749686
13male meiosis I (GO:0007141)4.84786590
14activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO4.83014528
15transcription elongation from RNA polymerase III promoter (GO:0006385)4.81923754
16termination of RNA polymerase III transcription (GO:0006386)4.81923754
17ventricular cardiac muscle cell development (GO:0055015)4.81148267
18positive regulation of protein oligomerization (GO:0032461)4.74904034
19ribosome assembly (GO:0042255)4.67698190
20mitotic metaphase plate congression (GO:0007080)4.42080186
21positive regulation of cAMP-mediated signaling (GO:0043950)4.41357728
22meiosis I (GO:0007127)4.39891529
23intestinal cholesterol absorption (GO:0030299)4.36283769
24mitochondrial RNA metabolic process (GO:0000959)4.33101501
25regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.31167441
26response to UV-C (GO:0010225)4.31141325
27regulation of mitochondrial translation (GO:0070129)4.22606970
28maturation of 5.8S rRNA (GO:0000460)4.16649683
29positive regulation of chromosome segregation (GO:0051984)4.16513905
30regulation of spindle organization (GO:0090224)4.16356312
31positive regulation of release of cytochrome c from mitochondria (GO:0090200)4.13324109
32ribonucleoprotein complex biogenesis (GO:0022613)4.11392245
33regulation of oxidative phosphorylation (GO:0002082)4.07215605
34regulation of transforming growth factor beta2 production (GO:0032909)4.02049014
35mitochondrion degradation (GO:0000422)3.96225444
36negative regulation of transcription by competitive promoter binding (GO:0010944)3.95096048
37tRNA methylation (GO:0030488)3.92376930
38rRNA processing (GO:0006364)3.89235031
39negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.79938338
40rRNA metabolic process (GO:0016072)3.76999739
41exploration behavior (GO:0035640)3.72533364
42protein targeting to mitochondrion (GO:0006626)3.66398368
43ribosome biogenesis (GO:0042254)3.56953236
44ribosomal large subunit biogenesis (GO:0042273)3.56899433
45viral transcription (GO:0019083)3.56421039
46translational termination (GO:0006415)3.53731712
47piRNA metabolic process (GO:0034587)3.50542997
48metaphase plate congression (GO:0051310)3.50210462
49regulation of cardioblast differentiation (GO:0051890)3.47481643
50ribosomal small subunit assembly (GO:0000028)3.45976887
51meiotic cell cycle (GO:0051321)3.45771058
52transcription from RNA polymerase III promoter (GO:0006383)3.45471716
53negative regulation of mRNA processing (GO:0050686)3.39328499
54maturation of SSU-rRNA (GO:0030490)3.39122572
55regulation of transforming growth factor beta1 production (GO:0032908)3.38708024
56snRNA transcription (GO:0009301)3.37635341
57pseudouridine synthesis (GO:0001522)3.34897608
58negative regulation of RNA splicing (GO:0033119)3.34423322
59regulation of DNA methylation (GO:0044030)3.33624139
60chaperone mediated protein folding requiring cofactor (GO:0051085)3.33009918
61mitotic sister chromatid segregation (GO:0000070)3.28430701
62nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.27650961
63negative regulation of epidermal cell differentiation (GO:0045605)3.25414193
64regulation of release of cytochrome c from mitochondria (GO:0090199)3.20272973
65cellular component biogenesis (GO:0044085)3.18549350
66positive regulation of cytokinesis (GO:0032467)3.16923953
67protein K6-linked ubiquitination (GO:0085020)3.16441565
68polyamine biosynthetic process (GO:0006596)3.16316662
69negative regulation of mRNA metabolic process (GO:1903312)3.16108144
70translational elongation (GO:0006414)3.14902401
71mitochondrial fusion (GO:0008053)3.14197788
72establishment of protein localization to mitochondrion (GO:0072655)3.12875024
73positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.10716264
74positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.10716264
75positive regulation of mitotic sister chromatid separation (GO:1901970)3.10716264
76regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:23.10531837
77translational initiation (GO:0006413)3.07351775
78regulation of cellular respiration (GO:0043457)3.06524570
79detection of chemical stimulus involved in sensory perception of taste (GO:0050912)3.06309844
80plasma lipoprotein particle assembly (GO:0034377)3.03213724
81outflow tract septum morphogenesis (GO:0003148)3.02527115
82regulation of mitotic spindle organization (GO:0060236)3.01419858
83protein localization to mitochondrion (GO:0070585)3.01045943
84RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.99021582
85RNA methylation (GO:0001510)2.97271231
86translation (GO:0006412)2.96420653
87ncRNA processing (GO:0034470)2.88233751
88mitotic chromosome condensation (GO:0007076)2.87626958
89SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.85112604
90cotranslational protein targeting to membrane (GO:0006613)2.77190095
91histone phosphorylation (GO:0016572)2.76330730
92establishment of protein localization to mitochondrial membrane (GO:0090151)2.75289195
93regulation of cytokine secretion involved in immune response (GO:0002739)2.74685637
94protein localization to chromosome, centromeric region (GO:0071459)2.74396004
95cellular protein complex disassembly (GO:0043624)2.71251097
96protein targeting to ER (GO:0045047)2.70671848
97exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.70086232
98negative regulation of retinoic acid receptor signaling pathway (GO:0048387)17.2673127
99regulation of retinoic acid receptor signaling pathway (GO:0048385)14.6419974
100positive regulation of protein homooligomerization (GO:0032464)10.3770460

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.94315211
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.14281586
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.11739866
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.81649191
5ETS1_20019798_ChIP-Seq_JURKAT_Human3.79847080
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.74154274
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.73789809
8NOTCH1_21737748_ChIP-Seq_TLL_Human3.73618701
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.62693744
10MYC_18555785_ChIP-Seq_MESCs_Mouse3.28786915
11E2F7_22180533_ChIP-Seq_HELA_Human3.20723958
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.07262442
13FOXM1_23109430_ChIP-Seq_U2OS_Human3.06538140
14KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.95460105
15KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.95460105
16KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.95460105
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.86270347
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.79679428
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.76220202
20ZNF263_19887448_ChIP-Seq_K562_Human2.72277158
21THAP11_20581084_ChIP-Seq_MESCs_Mouse2.51380572
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.48449260
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.41645287
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.31499346
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.19789796
26GABP_19822575_ChIP-Seq_HepG2_Human2.15933409
27MYC_19030024_ChIP-ChIP_MESCs_Mouse2.15669152
28ZNF274_21170338_ChIP-Seq_K562_Hela2.14570752
29VDR_23849224_ChIP-Seq_CD4+_Human2.13066613
30MYC_19079543_ChIP-ChIP_MESCs_Mouse2.12391417
31YY1_21170310_ChIP-Seq_MESCs_Mouse2.10411016
32TTF2_22483619_ChIP-Seq_HELA_Human2.08105473
33EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.97429790
34XRN2_22483619_ChIP-Seq_HELA_Human1.94811290
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.91124847
36RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.88937093
37SRF_21415370_ChIP-Seq_HL-1_Mouse1.84335556
38FOXP3_21729870_ChIP-Seq_TREG_Human1.81923247
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.72119465
40E2F4_17652178_ChIP-ChIP_JURKAT_Human1.70916704
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64378149
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55868470
43PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.53002908
44CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.50142511
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49213415
46LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.47044940
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45636183
48CIITA_25753668_ChIP-Seq_RAJI_Human1.45334922
49DCP1A_22483619_ChIP-Seq_HELA_Human1.44679217
50E2F1_18555785_ChIP-Seq_MESCs_Mouse1.39417759
51CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.36895606
52E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.26170599
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.25899860
54KDM5A_27292631_Chip-Seq_BREAST_Human1.23934912
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21303075
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.21233666
57CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.19005151
58TET1_21451524_ChIP-Seq_MESCs_Mouse1.17661218
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.16271481
60YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15913378
61SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.15159010
62AR_21909140_ChIP-Seq_LNCAP_Human1.14434324
63SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.13509333
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12371173
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11285874
66HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09760966
67KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07988783
68MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07712995
69CTCF_18555785_ChIP-Seq_MESCs_Mouse1.05172322
70SOX2_18555785_ChIP-Seq_MESCs_Mouse1.02433371
71CTCF_20526341_ChIP-Seq_ESCs_Human1.01870363
72CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.99504502
73ELK1_19687146_ChIP-ChIP_HELA_Human0.98936603
74CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98062222
75SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.97309092
76CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94416251
77SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.94178097
78STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.93877779
79ZFX_18555785_ChIP-Seq_MESCs_Mouse0.91918051
80ERG_20887958_ChIP-Seq_HPC-7_Mouse0.90833559
81CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.89501100
82E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89413401
83DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.88853144
84SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.88173981
85ETV1_20927104_ChIP-Seq_GIST48_Human0.86947420
86PHF8_20622853_ChIP-Seq_HELA_Human0.86664566
87NANOG_18555785_ChIP-Seq_MESCs_Mouse0.86128178
88GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.84359763
89ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84212455
90ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.83391506
91CTCF_21964334_Chip-Seq_Bcells_Human0.83344362
92LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82288035
93GATA6_21074721_ChIP-Seq_CACO-2_Human0.81084711
94RBPJ_21746931_ChIP-Seq_IB4_Human0.80190354
95* TP53_22573176_ChIP-Seq_HFKS_Human0.80133408
96TP63_19390658_ChIP-ChIP_HaCaT_Human0.78460857
97PADI4_21655091_ChIP-ChIP_MCF-7_Human0.78076925
98FLI1_21867929_ChIP-Seq_CD8_Mouse0.77835242
99TFEB_21752829_ChIP-Seq_HELA_Human0.75786436
100CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.75587613

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005423_abnormal_somatic_nervous9.05493313
2MP0008260_abnormal_autophagy5.23856034
3MP0003646_muscle_fatigue4.12762268
4MP0009379_abnormal_foot_pigmentation3.80808254
5MP0003693_abnormal_embryo_hatching3.68454546
6MP0003718_maternal_effect3.50867059
7MP0004957_abnormal_blastocyst_morpholog2.86778188
8MP0003111_abnormal_nucleus_morphology2.78769991
9MP0009333_abnormal_splenocyte_physiolog2.25906207
10MP0003077_abnormal_cell_cycle2.06579409
11MP0001986_abnormal_taste_sensitivity10.6282449
12MP0006292_abnormal_olfactory_placode1.76885993
13MP0002127_abnormal_cardiovascular_syste1.75847226
14MP0000750_abnormal_muscle_regeneration1.58220299
15MP0008058_abnormal_DNA_repair1.42927675
16MP0006036_abnormal_mitochondrial_physio1.38414062
17MP0010094_abnormal_chromosome_stability1.37744789
18MP0002160_abnormal_reproductive_system1.35863818
19MP0008877_abnormal_DNA_methylation1.33065339
20MP0005380_embryogenesis_phenotype1.30952470
21MP0001672_abnormal_embryogenesis/_devel1.30952470
22MP0009840_abnormal_foam_cell1.30273619
23MP0001929_abnormal_gametogenesis1.28905611
24MP0001666_abnormal_nutrient_absorption1.24413738
25MP0008932_abnormal_embryonic_tissue1.22664537
26MP0000490_abnormal_crypts_of1.21613272
27MP0000462_abnormal_digestive_system1.21287691
28MP0006035_abnormal_mitochondrial_morpho1.20624625
29MP0001346_abnormal_lacrimal_gland1.19535439
30MP0001730_embryonic_growth_arrest1.15399597
31MP0003984_embryonic_growth_retardation1.14885390
32MP0002210_abnormal_sex_determination1.14173383
33MP0005395_other_phenotype1.13803948
34MP0003938_abnormal_ear_development1.13260282
35MP0004019_abnormal_vitamin_homeostasis1.13256271
36MP0010030_abnormal_orbit_morphology1.13001521
37MP0001697_abnormal_embryo_size1.12982085
38MP0005389_reproductive_system_phenotype1.11868736
39MP0000350_abnormal_cell_proliferation1.09825944
40MP0000358_abnormal_cell_content/1.09363848
41MP0002088_abnormal_embryonic_growth/wei1.09002226
42MP0003191_abnormal_cellular_cholesterol1.05760812
43MP0002332_abnormal_exercise_endurance1.01422150
44MP0010307_abnormal_tumor_latency1.01248172
45MP0005058_abnormal_lysosome_morphology1.01140239
46MP0005451_abnormal_body_composition1.00220633
47MP0000015_abnormal_ear_pigmentation0.99866202
48MP0003943_abnormal_hepatobiliary_system0.89840478
49MP0008789_abnormal_olfactory_epithelium0.87617272
50MP0000313_abnormal_cell_death0.82264676
51MP0002080_prenatal_lethality0.80801238
52MP0002085_abnormal_embryonic_tissue0.78228677
53MP0005394_taste/olfaction_phenotype0.76410927
54MP0005499_abnormal_olfactory_system0.76410927
55MP0004885_abnormal_endolymph0.75556438
56MP0000733_abnormal_muscle_development0.75277320
57MP0008995_early_reproductive_senescence0.72339503
58MP0001919_abnormal_reproductive_system0.70894394
59MP0002161_abnormal_fertility/fecundity0.68846258
60MP0000653_abnormal_sex_gland0.68174461
61MP0003119_abnormal_digestive_system0.68010027
62MP0001145_abnormal_male_reproductive0.67681239
63MP0001529_abnormal_vocalization0.67347943
64MP0002086_abnormal_extraembryonic_tissu0.66882072
65MP0001881_abnormal_mammary_gland0.65372397
66MP0003186_abnormal_redox_activity0.63277518
67MP0003136_yellow_coat_color0.61654922
68MP0002084_abnormal_developmental_patter0.61310320
69MP0002277_abnormal_respiratory_mucosa0.61148557
70MP0003698_abnormal_male_reproductive0.60456064
71MP0003699_abnormal_female_reproductive0.59572645
72MP0000678_abnormal_parathyroid_gland0.58369522
73MP0002653_abnormal_ependyma_morphology0.56599385
74MP0001286_abnormal_eye_development0.56299539
75MP0005410_abnormal_fertilization0.54590051
76MP0002735_abnormal_chemical_nociception0.54235876
77MP0005085_abnormal_gallbladder_physiolo0.53904923
78MP0003252_abnormal_bile_duct0.53838083
79MP0000477_abnormal_intestine_morphology0.52156608
80MP0002095_abnormal_skin_pigmentation0.51156865
81MP0004215_abnormal_myocardial_fiber0.49894217
82MP0001905_abnormal_dopamine_level0.48492857
83MP0003315_abnormal_perineum_morphology0.48422086
84MP0002873_normal_phenotype0.48186649
85MP0002169_no_abnormal_phenotype0.48056198
86MP0000049_abnormal_middle_ear0.47352397
87MP0002106_abnormal_muscle_physiology0.46326843
88MP0005647_abnormal_sex_gland0.46295728
89MP0001293_anophthalmia0.44180236
90MP0004036_abnormal_muscle_relaxation0.44001492
91MP0010368_abnormal_lymphatic_system0.43641789
92MP0008057_abnormal_DNA_replication0.43622798
93MP0003879_abnormal_hair_cell0.42890571
94MP0003936_abnormal_reproductive_system0.42191479
95MP0001119_abnormal_female_reproductive0.41401854
96MP0008007_abnormal_cellular_replicative0.41336309
97MP0001849_ear_inflammation0.39719520
98MP0005174_abnormal_tail_pigmentation0.38498956
99MP0005645_abnormal_hypothalamus_physiol0.35802919
100MP0002163_abnormal_gland_morphology0.34228356

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)7.58221900
2Congenital malformation of the right heart (HP:0011723)5.34898154
3Double outlet right ventricle (HP:0001719)5.34898154
4Microvesicular hepatic steatosis (HP:0001414)5.25762843
5Patent foramen ovale (HP:0001655)4.86216668
6Birth length less than 3rd percentile (HP:0003561)4.81125020
7Abnormal pancreas size (HP:0012094)4.56113454
8Hypercortisolism (HP:0001578)4.55714625
9Abnormality of the fetal cardiovascular system (HP:0010948)4.26493354
10Abnormal umbilical cord blood vessels (HP:0011403)4.26493354
11Single umbilical artery (HP:0001195)4.26493354
12Abnormality of the aortic arch (HP:0012303)4.18117417
13Carpal bone hypoplasia (HP:0001498)3.97323008
14Short tibia (HP:0005736)3.90879098
15Progressive muscle weakness (HP:0003323)3.74091190
16Aplasia/hypoplasia of the uterus (HP:0008684)3.60442191
17Hypergonadotropic hypogonadism (HP:0000815)3.56399802
18Ureteral duplication (HP:0000073)3.55571245
19Ragged-red muscle fibers (HP:0003200)3.51769681
20Reduced antithrombin III activity (HP:0001976)3.46235624
21Aplasia/Hypoplasia of the tibia (HP:0005772)3.45801245
22Supernumerary spleens (HP:0009799)3.43672314
23Myopathic facies (HP:0002058)3.39371274
24Absent rod-and cone-mediated responses on ERG (HP:0007688)3.34948957
25Increased serum pyruvate (HP:0003542)3.05282082
26Premature ovarian failure (HP:0008209)3.04770418
27Truncus arteriosus (HP:0001660)3.02778678
28Hypoglycemic seizures (HP:0002173)3.00911353
29Stenosis of the external auditory canal (HP:0000402)2.97771907
30Hypoplasia of the uterus (HP:0000013)2.94668967
31Abnormality of the septum pellucidum (HP:0007375)2.94534969
32Fused cervical vertebrae (HP:0002949)2.90920216
33Hyperglycemia (HP:0003074)2.86973028
34Abnormality of cells of the erythroid lineage (HP:0012130)2.84270979
35Ileus (HP:0002595)2.80111096
36Midline defect of the nose (HP:0004122)2.79447877
37Progressive external ophthalmoplegia (HP:0000590)2.79387273
38Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.76415611
39Cleft eyelid (HP:0000625)2.75754580
40Reticulocytopenia (HP:0001896)2.70740178
41Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.68570490
42Dysautonomia (HP:0002459)2.60683313
43Facial cleft (HP:0002006)2.60253040
44Preauricular pit (HP:0004467)2.57615611
45Periauricular skin pits (HP:0100277)2.57615611
46Symptomatic seizures (HP:0011145)2.54237015
47Multiple enchondromatosis (HP:0005701)2.53172810
48Infertility (HP:0000789)2.51384785
49Abnormality of the umbilical cord (HP:0010881)2.51011271
50Aplasia/Hypoplasia involving the musculature (HP:0001460)2.50588125
51Abnormal number of erythroid precursors (HP:0012131)2.49495646
52Abnormal lung lobation (HP:0002101)2.47074060
53Hyperinsulinemic hypoglycemia (HP:0000825)2.45074119
54Constricted visual fields (HP:0001133)2.44310761
55Abnormality of the phalanges of the hallux (HP:0010057)2.41523558
56Breast hypoplasia (HP:0003187)2.40528909
57Dysphonia (HP:0001618)2.39560519
58Hypoplasia of the pons (HP:0012110)2.38319513
59Absent septum pellucidum (HP:0001331)2.36125128
60Horseshoe kidney (HP:0000085)2.34581843
61Type I transferrin isoform profile (HP:0003642)2.34096047
62Abnormality of glycolysis (HP:0004366)2.33429399
63Increased serum lactate (HP:0002151)2.33378416
64Posterior subcapsular cataract (HP:0007787)2.33264048
65Rough bone trabeculation (HP:0100670)2.33164865
66Microretrognathia (HP:0000308)2.28987253
67Anhidrosis (HP:0000970)2.28797179
68Oral leukoplakia (HP:0002745)2.28685214
69Sensory axonal neuropathy (HP:0003390)2.27577150
70Abnormality of the pons (HP:0007361)2.25658705
71Abnormal ventriculo-arterial connection (HP:0011563)2.24823830
72Transposition of the great arteries (HP:0001669)2.24823830
73Abnormal connection of the cardiac segments (HP:0011545)2.24823830
74External ophthalmoplegia (HP:0000544)2.22951250
75Adrenal overactivity (HP:0002717)2.22477145
76Absent radius (HP:0003974)2.21498680
77Abnormality of the intrinsic pathway (HP:0010989)2.20898534
78Rhabdomyolysis (HP:0003201)2.19947350
79Pili torti (HP:0003777)2.16293640
80Absent thumb (HP:0009777)2.13593920
81Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.13425851
82Abnormal rod and cone electroretinograms (HP:0008323)2.12905105
83Tubulointerstitial nephritis (HP:0001970)2.12839956
84Increased CSF lactate (HP:0002490)2.10991756
85Testicular atrophy (HP:0000029)2.10299781
86Glossoptosis (HP:0000162)2.10277387
87Aplasia involving forearm bones (HP:0009822)2.09987540
88Absent forearm bone (HP:0003953)2.09987540
89Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.09958199
90Short 1st metacarpal (HP:0010034)2.09958199
91Tongue fasciculations (HP:0001308)2.09443998
92Osteomalacia (HP:0002749)2.07723980
93Median cleft lip (HP:0000161)2.05012821
94Trismus (HP:0000211)2.04903102
95Glycosuria (HP:0003076)2.03150025
96Abnormality of urine glucose concentration (HP:0011016)2.03150025
97Impaired social interactions (HP:0000735)2.01167099
98Abnormal social behavior (HP:0012433)2.01167099
99Hypoplasia of the radius (HP:0002984)2.00567492
100Ependymoma (HP:0002888)1.92162774

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB16.57746402
2SRPK14.28380638
3TESK23.77321657
4LATS23.57776013
5BRSK13.24651453
6BMX3.17831147
7CDK192.95637596
8BRSK22.92053403
9STK162.74773017
10PAK62.41246277
11AURKA2.31962725
12PLK12.16863094
13NUAK12.09654829
14MARK31.96141985
15PLK31.84036703
16PBK1.83686236
17AURKB1.71764705
18TAOK31.66173603
19CHEK21.60200175
20NEK61.58770589
21PINK11.48105133
22PDK21.44627227
23TESK11.44463376
24NEK21.44404011
25NME21.44334125
26DYRK31.40792086
27CHEK11.31535405
28EPHA41.29892189
29TRIM281.27141741
30KSR21.24140639
31PAK11.18089900
32PRKD21.18039210
33NME11.15295209
34STK101.13489234
35LRRK21.10048496
36CSNK2A11.08134140
37PKN11.07735846
38STK41.07367823
39PLK41.06544134
40PAK21.02057833
41MAPK110.99017056
42KDR0.98715391
43RAF10.94238218
44MAP3K80.91124032
45TTK0.89838916
46VRK20.88734993
47CDK70.82316722
48MELK0.82276709
49CSNK2A20.81322389
50FGR0.79059781
51PIM10.78099730
52RPS6KA10.74479639
53AKT20.70696738
54ATR0.67126582
55PRKG10.60572264
56CDK20.60499698
57PRKD10.59208586
58CSNK1A10.57267435
59CDK10.56935408
60PRKACB0.55214342
61MAP3K50.54158241
62WNK30.52185511
63NTRK30.51001882
64KSR10.49199387
65ZAK0.49174143
66EIF2AK30.48569399
67JAK30.47705769
68MAP2K10.46136863
69PRKCI0.42703944
70CDC70.42620444
71EIF2AK10.42205448
72GSK3A0.42056004
73SCYL20.41181033
74STK30.40059892
75CSNK1E0.39973956
76ATM0.38632727
77CDK11A0.37480265
78ERBB40.37368856
79MAPK10.37334067
80VRK10.36856020
81MAP3K10.36386699
82ABL20.30885008
83CDK40.29645140
84MTOR0.29067881
85MAP2K20.27973722
86PRKAA10.27732681
87CAMK40.27046366
88ILK0.26951059
89PRKCH0.26948811
90PRKCE0.24828862
91GSK3B0.24684853
92PRKACA0.24643096
93MAPKAPK20.24386145
94MAP3K20.22187928
95MAPK140.19973626
96ALK0.19413130
97CAMK2G0.17086332
98CDK80.16682074
99CDC42BPA0.16066126
100CDK30.15672367

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030085.77557902
2Regulation of autophagy_Homo sapiens_hsa041405.69929251
3Ribosome_Homo sapiens_hsa030105.67341203
4RNA polymerase_Homo sapiens_hsa030204.61658672
5RNA transport_Homo sapiens_hsa030133.05806491
6Basal transcription factors_Homo sapiens_hsa030222.89517895
7Folate biosynthesis_Homo sapiens_hsa007902.66730514
8Spliceosome_Homo sapiens_hsa030402.59184967
9mRNA surveillance pathway_Homo sapiens_hsa030152.52514346
10Pyrimidine metabolism_Homo sapiens_hsa002402.27676089
11Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.11127499
12Steroid biosynthesis_Homo sapiens_hsa001002.01135102
13DNA replication_Homo sapiens_hsa030301.97122586
14Cell cycle_Homo sapiens_hsa041101.96744926
15RNA degradation_Homo sapiens_hsa030181.89126662
16Base excision repair_Homo sapiens_hsa034101.84330985
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.72724019
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.72047336
19Mismatch repair_Homo sapiens_hsa034301.67186181
20Proteasome_Homo sapiens_hsa030501.66750725
21Oocyte meiosis_Homo sapiens_hsa041141.64598048
22p53 signaling pathway_Homo sapiens_hsa041151.55750409
23Huntingtons disease_Homo sapiens_hsa050161.32122429
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.24251031
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.20737052
26Taste transduction_Homo sapiens_hsa047421.20487241
27Parkinsons disease_Homo sapiens_hsa050121.14964148
28Purine metabolism_Homo sapiens_hsa002301.12748102
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.12747697
30SNARE interactions in vesicular transport_Homo sapiens_hsa041301.12036814
31Homologous recombination_Homo sapiens_hsa034401.09454104
32Fanconi anemia pathway_Homo sapiens_hsa034601.06282639
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.95364386
34Cardiac muscle contraction_Homo sapiens_hsa042600.95006912
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.93616974
36Protein export_Homo sapiens_hsa030600.89441061
37Inositol phosphate metabolism_Homo sapiens_hsa005620.89086697
38Fatty acid elongation_Homo sapiens_hsa000620.87901693
39Fatty acid biosynthesis_Homo sapiens_hsa000610.80402521
40Glycerophospholipid metabolism_Homo sapiens_hsa005640.74045830
41Oxidative phosphorylation_Homo sapiens_hsa001900.73648155
42Epstein-Barr virus infection_Homo sapiens_hsa051690.72288205
43Glutathione metabolism_Homo sapiens_hsa004800.72258784
44Selenocompound metabolism_Homo sapiens_hsa004500.69638505
45Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.65947945
46Maturity onset diabetes of the young_Homo sapiens_hsa049500.62436304
47Cysteine and methionine metabolism_Homo sapiens_hsa002700.62363745
48Nucleotide excision repair_Homo sapiens_hsa034200.60758889
49Wnt signaling pathway_Homo sapiens_hsa043100.56012996
50Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55701228
51Herpes simplex infection_Homo sapiens_hsa051680.54993539
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52705819
53Hedgehog signaling pathway_Homo sapiens_hsa043400.51115970
54Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49872100
55Viral carcinogenesis_Homo sapiens_hsa052030.49285162
56Insulin secretion_Homo sapiens_hsa049110.48369389
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48156441
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46165435
59RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.44391004
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41070490
61Fructose and mannose metabolism_Homo sapiens_hsa000510.41066528
62Synaptic vesicle cycle_Homo sapiens_hsa047210.40245204
63Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39396644
64Dorso-ventral axis formation_Homo sapiens_hsa043200.34995623
65MicroRNAs in cancer_Homo sapiens_hsa052060.32030555
66Metabolic pathways_Homo sapiens_hsa011000.31486502
67Shigellosis_Homo sapiens_hsa051310.30773223
68Hippo signaling pathway_Homo sapiens_hsa043900.29789606
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28144148
70Arginine and proline metabolism_Homo sapiens_hsa003300.26133365
71Apoptosis_Homo sapiens_hsa042100.22026927
72Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.21602195
73Alzheimers disease_Homo sapiens_hsa050100.20671972
74Sulfur metabolism_Homo sapiens_hsa009200.20180189
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19018929
76Renal cell carcinoma_Homo sapiens_hsa052110.16526451
77Ether lipid metabolism_Homo sapiens_hsa005650.15871694
78Olfactory transduction_Homo sapiens_hsa047400.13528396
79Sulfur relay system_Homo sapiens_hsa041220.12911424
80Adherens junction_Homo sapiens_hsa045200.11055454
81Circadian rhythm_Homo sapiens_hsa047100.09666983
82Protein digestion and absorption_Homo sapiens_hsa049740.09017649
83Caffeine metabolism_Homo sapiens_hsa002320.08334977
84FoxO signaling pathway_Homo sapiens_hsa040680.08268024
85HIF-1 signaling pathway_Homo sapiens_hsa040660.08194423
86N-Glycan biosynthesis_Homo sapiens_hsa005100.07345969
87Nitrogen metabolism_Homo sapiens_hsa009100.07273596
88One carbon pool by folate_Homo sapiens_hsa006700.06944656
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.06588536
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.05631685
91Endocytosis_Homo sapiens_hsa041440.04971107
92Collecting duct acid secretion_Homo sapiens_hsa049660.03062846
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.02468482
94AMPK signaling pathway_Homo sapiens_hsa041520.02108261
95Small cell lung cancer_Homo sapiens_hsa052220.01335627
96Hepatitis B_Homo sapiens_hsa051610.01125270
97Sphingolipid metabolism_Homo sapiens_hsa006000.00176570
98Non-homologous end-joining_Homo sapiens_hsa03450-0.0159042
99Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.0128674
100Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0035616

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »