DPP9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is a member of the S9B family in clan SC of the serine proteases. The protein has been shown to have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Although the activity of this protein is similar to that of dipeptidyl peptidase 4 (DPP4), it does not appear to be membrane bound. In general, dipeptidyl peptidases appear to be involved in the regulation of the activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. Several transcript variants of this gene have been described but not fully characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)5.68099780
2Golgi transport vesicle coating (GO:0048200)5.68099780
3L-phenylalanine metabolic process (GO:0006558)4.68306232
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.68306232
5L-phenylalanine catabolic process (GO:0006559)4.62773220
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.62773220
7regulation of cholesterol homeostasis (GO:2000188)4.43617832
8protein carboxylation (GO:0018214)4.30987516
9peptidyl-glutamic acid carboxylation (GO:0017187)4.30987516
10activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.29620737
11positive regulation of nuclease activity (GO:0032075)4.20825202
12protein localization to endosome (GO:0036010)4.19886862
13negative regulation of fibrinolysis (GO:0051918)4.14292280
14lysine catabolic process (GO:0006554)4.10574133
15lysine metabolic process (GO:0006553)4.10574133
16hemidesmosome assembly (GO:0031581)4.06522718
174-hydroxyproline metabolic process (GO:0019471)4.00694676
18alpha-linolenic acid metabolic process (GO:0036109)3.94384221
19L-alpha-amino acid transmembrane transport (GO:1902475)3.90194008
20oxaloacetate metabolic process (GO:0006107)3.89381424
21negative regulation of cell size (GO:0045792)3.88627123
22maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.82454988
23regulation of fatty acid beta-oxidation (GO:0031998)3.82278749
24kynurenine metabolic process (GO:0070189)3.81168286
25triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.80101533
26positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.79681568
27tricarboxylic acid metabolic process (GO:0072350)3.78680136
282-oxoglutarate metabolic process (GO:0006103)3.77892828
29regulation of nuclease activity (GO:0032069)3.76705629
30aromatic amino acid family catabolic process (GO:0009074)3.74477491
31retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.71939170
32negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.69886349
33protein retention in ER lumen (GO:0006621)3.62728578
34sulfur amino acid catabolic process (GO:0000098)3.61361713
35COPII vesicle coating (GO:0048208)3.60871823
36valine metabolic process (GO:0006573)3.59424618
37endoplasmic reticulum unfolded protein response (GO:0030968)3.57565103
38positive regulation of triglyceride biosynthetic process (GO:0010867)3.57427954
39cell-substrate junction assembly (GO:0007044)3.53121054
40glyoxylate metabolic process (GO:0046487)3.52544865
41positive regulation of fatty acid beta-oxidation (GO:0032000)3.48218486
42intestinal cholesterol absorption (GO:0030299)3.46667355
43negative regulation of cholesterol transport (GO:0032375)3.43576519
44negative regulation of sterol transport (GO:0032372)3.43576519
45positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.43063224
46protein maturation by protein folding (GO:0022417)3.41528303
47NIK/NF-kappaB signaling (GO:0038061)3.41206601
48regulation of fibrinolysis (GO:0051917)3.40532103
49cellular response to unfolded protein (GO:0034620)3.40401998
50cellular modified amino acid catabolic process (GO:0042219)3.38449647
51positive regulation of histone deacetylation (GO:0031065)3.37746967
52urea metabolic process (GO:0019627)3.37744212
53urea cycle (GO:0000050)3.37744212
54ER-nucleus signaling pathway (GO:0006984)3.36429946
55complement activation, alternative pathway (GO:0006957)3.35908358
56cysteine metabolic process (GO:0006534)3.34589204
57dicarboxylic acid biosynthetic process (GO:0043650)3.34095946
58activation of Rac GTPase activity (GO:0032863)3.30110190
59mannose metabolic process (GO:0006013)3.27716720
60pinocytosis (GO:0006907)3.27409060
61maternal placenta development (GO:0001893)3.24004254
62regulation of protein activation cascade (GO:2000257)3.20611324
63cellular response to topologically incorrect protein (GO:0035967)3.19864611
64glycine metabolic process (GO:0006544)3.17612863
65regulation of apoptotic process involved in morphogenesis (GO:1902337)3.16170772
66folic acid-containing compound biosynthetic process (GO:0009396)3.15588236
67high-density lipoprotein particle remodeling (GO:0034375)3.14355944
68barbed-end actin filament capping (GO:0051016)3.12097024
69positive regulation of triglyceride metabolic process (GO:0090208)3.11999451
70bile acid biosynthetic process (GO:0006699)3.10745942
71focal adhesion assembly (GO:0048041)3.09657046
72cell-substrate adherens junction assembly (GO:0007045)3.09657046
73positive regulation of fatty acid biosynthetic process (GO:0045723)3.05382317
74homocysteine metabolic process (GO:0050667)3.05122132
75regulation of early endosome to late endosome transport (GO:2000641)3.03568570
76pentose-phosphate shunt (GO:0006098)3.02945613
77tryptophan catabolic process (GO:0006569)3.02619445
78indole-containing compound catabolic process (GO:0042436)3.02619445
79indolalkylamine catabolic process (GO:0046218)3.02619445
80aspartate family amino acid catabolic process (GO:0009068)3.02605509
81antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.02159764
82antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.02159764
83nitrogen cycle metabolic process (GO:0071941)3.01071922
84positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.00442497
85cellular response to virus (GO:0098586)2.99091049
86fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.99064356
87apoptotic process involved in morphogenesis (GO:0060561)2.97360304
88coenzyme catabolic process (GO:0009109)2.96887017
89plasma lipoprotein particle clearance (GO:0034381)2.94332630
90regulation of integrin activation (GO:0033623)2.93596423
91regulation of complement activation (GO:0030449)2.93077231
92negative regulation of lipid transport (GO:0032369)2.93048001
93phospholipid efflux (GO:0033700)2.91514829
94vesicle coating (GO:0006901)2.91360487
95negative regulation of erythrocyte differentiation (GO:0045647)2.90485159
96negative regulation of viral release from host cell (GO:1902187)2.89245593
97stress fiber assembly (GO:0043149)2.88955364
98adherens junction assembly (GO:0034333)2.88042421
99glutamate metabolic process (GO:0006536)2.87913682
100fatty acid homeostasis (GO:0055089)2.87701766
101tryptophan metabolic process (GO:0006568)2.87575594
102positive regulation of fatty acid oxidation (GO:0046321)2.87226458
103cellular ketone body metabolic process (GO:0046950)2.85983547
104positive regulation of lipid catabolic process (GO:0050996)2.84513604
105regulation of fatty acid oxidation (GO:0046320)2.83795344
106regulation of mammary gland epithelial cell proliferation (GO:0033599)2.83205265
107skin morphogenesis (GO:0043589)2.80919334
108regulation of triglyceride biosynthetic process (GO:0010866)2.80461995
109acute-phase response (GO:0006953)2.80386439
110negative regulation of fatty acid transport (GO:2000192)2.79078476
111one-carbon metabolic process (GO:0006730)2.78469610
112response to laminar fluid shear stress (GO:0034616)2.75766735
113reverse cholesterol transport (GO:0043691)2.74943585
114protein-lipid complex assembly (GO:0065005)2.74531181
115positive regulation of Cdc42 GTPase activity (GO:0043089)2.73533637
116phospholipid homeostasis (GO:0055091)2.73273798
117desmosome organization (GO:0002934)2.72401724
118regulation of type I interferon-mediated signaling pathway (GO:0060338)2.72177404
119plasma lipoprotein particle assembly (GO:0034377)2.71278678
120regulation of triglyceride catabolic process (GO:0010896)2.71145148
121response to endoplasmic reticulum stress (GO:0034976)2.70502947
122killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.69354251
123disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.69354251
124serine family amino acid catabolic process (GO:0009071)2.69189336
125alpha-amino acid catabolic process (GO:1901606)2.68003277
126acylglycerol homeostasis (GO:0055090)2.67781494
127triglyceride homeostasis (GO:0070328)2.67781494
128positive regulation of fatty acid metabolic process (GO:0045923)2.67656826
129regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.67151479
130basement membrane organization (GO:0071711)2.65901261
131regulation of glucose import in response to insulin stimulus (GO:2001273)2.64698071
132cell adhesion mediated by integrin (GO:0033627)2.63842129
133aromatic amino acid family metabolic process (GO:0009072)2.62205025
134positive regulation of blood vessel endothelial cell migration (GO:0043536)2.61171443
135modulation by symbiont of host cellular process (GO:0044068)2.60726227
136positive regulation of extracellular matrix organization (GO:1903055)2.60287322
137membrane protein ectodomain proteolysis (GO:0006509)2.55288321
138regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.53339583
139regulation of somitogenesis (GO:0014807)2.52308866
140membrane raft organization (GO:0031579)2.51988535
141antigen processing and presentation of endogenous antigen (GO:0019883)2.51294826
142mammary gland epithelial cell proliferation (GO:0033598)2.50648268
143low-density lipoprotein particle clearance (GO:0034383)2.50590429
144interferon-gamma secretion (GO:0072643)2.49828624
145regulation of extracellular matrix disassembly (GO:0010715)2.49076557
146regulation of necroptotic process (GO:0060544)2.47937730
147response to peptidoglycan (GO:0032494)2.46827760
148response to muramyl dipeptide (GO:0032495)2.44534628
149semaphorin-plexin signaling pathway (GO:0071526)2.44138693
150germinal center formation (GO:0002467)2.40828633
151hyaluronan catabolic process (GO:0030214)2.39669374
152lipopolysaccharide-mediated signaling pathway (GO:0031663)2.35223886
153negative regulation of necroptotic process (GO:0060546)2.35209435
154hypotonic response (GO:0006971)2.32744503
155regulation of vitamin D biosynthetic process (GO:0060556)2.31413542
156trophoblast giant cell differentiation (GO:0060707)2.30846621
157regulation of superoxide anion generation (GO:0032928)2.30053796
158regulation of leukocyte degranulation (GO:0043300)2.29280640
159endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.29199743
160regulation of membrane protein ectodomain proteolysis (GO:0051043)2.27837895
161UV protection (GO:0009650)2.27560498
162vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.27272065
163embryonic process involved in female pregnancy (GO:0060136)2.26512343
164adhesion of symbiont to host (GO:0044406)2.25648749
165regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.24226044
166apoptotic cell clearance (GO:0043277)2.23646483
167activation of MAPKKK activity (GO:0000185)2.22697690
168regulation of translational termination (GO:0006449)2.22299141
169cellular response to arsenic-containing substance (GO:0071243)2.22134701
170substrate-dependent cell migration (GO:0006929)2.21792935
171antigen processing and presentation via MHC class Ib (GO:0002475)2.20780944
172positive regulation of protein dephosphorylation (GO:0035307)2.19647379
173cellular response to nutrient (GO:0031670)2.18857792
174endodermal cell differentiation (GO:0035987)2.18741841
175cellular response to exogenous dsRNA (GO:0071360)2.18137077
176regulation of necrotic cell death (GO:0010939)2.16766416
177decidualization (GO:0046697)2.16591651
178modulation by virus of host process (GO:0019054)2.16192009
179endothelial cell chemotaxis (GO:0035767)2.15599484
180modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.14377446
181positive regulation by organism of defense response of other organism involved in symbiotic interact2.14377446
182modulation by symbiont of host immune response (GO:0052553)2.14377446
183positive regulation by symbiont of host defense response (GO:0052509)2.14377446
184modulation by symbiont of host defense response (GO:0052031)2.14377446
185modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.14377446
186branching involved in mammary gland duct morphogenesis (GO:0060444)2.14207185
187regulation of histone H3-K27 methylation (GO:0061085)2.13456622
188positive regulation of protein deacetylation (GO:0090312)2.13031428

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.64312228
2RXR_22158963_ChIP-Seq_LIVER_Mouse3.96960255
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.79864401
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.68644110
5MYC_22102868_ChIP-Seq_BL_Human3.19659787
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.13397518
7LXR_22158963_ChIP-Seq_LIVER_Mouse2.99958119
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.97519522
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.87380334
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.61964686
11LXR_22292898_ChIP-Seq_THP-1_Human2.54683767
12VDR_21846776_ChIP-Seq_THP-1_Human2.49321755
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.28358209
14* FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.25722487
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.12842539
16TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.12368236
17KDM2B_26808549_Chip-Seq_DND41_Human2.09590084
18CLOCK_20551151_ChIP-Seq_293T_Human2.07626387
19NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.07035076
20* ELK3_25401928_ChIP-Seq_HUVEC_Human2.02631215
21CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.02441065
22KDM2B_26808549_Chip-Seq_SUP-B15_Human2.02372496
23TCF7_22412390_ChIP-Seq_EML_Mouse1.97247286
24KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.89694043
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86449971
26KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.79069216
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.78418616
28* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.74659446
29RACK7_27058665_Chip-Seq_MCF-7_Human1.66986571
30ZNF263_19887448_ChIP-Seq_K562_Human1.66907081
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.65991927
32RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.64187554
33FOXM1_23109430_ChIP-Seq_U2OS_Human1.62516725
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.62333282
35ZFP281_18757296_ChIP-ChIP_E14_Mouse1.59775105
36TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.56341142
37* UTX_26944678_Chip-Seq_JUKART_Human1.54110158
38MAF_26560356_Chip-Seq_TH1_Human1.53709588
39EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48647694
40HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.47536776
41STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.44674284
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.42374312
43CREB1_26743006_Chip-Seq_LNCaP_Human1.41058867
44ESR2_21235772_ChIP-Seq_MCF-7_Human1.40332017
45CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.37270100
46* VDR_24763502_ChIP-Seq_THP-1_Human1.36669763
47EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.34925281
48ATF3_27146783_Chip-Seq_COLON_Human1.34820662
49TP53_22127205_ChIP-Seq_IMR90_Human1.34681160
50KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.34592164
51* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.33021136
52TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32732077
53P300_27058665_Chip-Seq_ZR-75-30cells_Human1.32255444
54* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.31723782
55* UBF1/2_26484160_Chip-Seq_HMECs_Human1.30638984
56* ELF1_20517297_ChIP-Seq_JURKAT_Human1.30568331
57P68_20966046_ChIP-Seq_HELA_Human1.28910413
58KDM2B_26808549_Chip-Seq_K562_Human1.27979538
59STAT4_19710469_ChIP-ChIP_TH1__Mouse1.27557724
60STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.27036321
61KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.26454266
62DNAJC2_21179169_ChIP-ChIP_NT2_Human1.23825782
63FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.23255794
64KDM2B_26808549_Chip-Seq_JURKAT_Human1.22749896
65TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.22500583
66FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.22465981
67* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21993714
68CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.21904917
69GATA1_22025678_ChIP-Seq_K562_Human1.20925521
70NCOR1_26117541_ChIP-Seq_K562_Human1.19158544
71TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.18776409
72CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.18288883
73IRF8_22096565_ChIP-ChIP_GC-B_Human1.18013156
74MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.17874118
75ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.17034631
76PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14161089
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13986489
78CIITA_25753668_ChIP-Seq_RAJI_Human1.13315138
79RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.11482550
80SPI1_23127762_ChIP-Seq_K562_Human1.11336637
81TET1_21451524_ChIP-Seq_MESCs_Mouse1.11283666
82RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.10069529
83CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08824472
84CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08599927
85* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.08194438
86* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.08118632
87SA1_27219007_Chip-Seq_ERYTHROID_Human1.07915084
88SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.07891201
89SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.07891201
90SRY_22984422_ChIP-ChIP_TESTIS_Rat1.07754841
91GATA1_19941827_ChIP-Seq_MEL_Mouse1.07603081
92MAF_26560356_Chip-Seq_TH2_Human1.07571299
93MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.07570398
94KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07542661
95BCOR_27268052_Chip-Seq_Bcells_Human1.06993714
96ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.06328254
97* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.06320443
98GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06198877
99CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.05908587
100KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05847013
101* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.05461634
102TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04811975
103DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.04736842
104* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.04658474
105GATA1_19941826_ChIP-Seq_K562_Human1.03999016
106HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.03981014
107CTCF_21964334_ChIP-Seq_BJAB-B_Human1.03551008
108CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02893870
109SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.02797097
110MYB_21317192_ChIP-Seq_ERMYB_Mouse1.01430134
111STAT3_1855785_ChIP-Seq_MESCs_Mouse1.01167145
112CTCF_21964334_Chip-Seq_Bcells_Human1.00403407
113ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.00389251
114UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00308873
115BCL6_27268052_Chip-Seq_Bcells_Human1.00206822
116FOXA2_19822575_ChIP-Seq_HepG2_Human0.98730142
117GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97324895
118SMC4_20622854_ChIP-Seq_HELA_Human0.97061565
119* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.96601285
120* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96562718
121TBX20_22080862_ChIP-Seq_HEART_Mouse0.96495506
122TBX20_22328084_ChIP-Seq_HEART_Mouse0.96495506
123CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95987036
124SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95475469
125NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.95032434
126GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95013964
127SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.94794576
128PU.1_20513432_ChIP-Seq_Bcells_Mouse0.94633329
129* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.94174821

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.67415162
2MP0005360_urolithiasis3.74965057
3MP0005365_abnormal_bile_salt3.72154256
4MP0003705_abnormal_hypodermis_morpholog3.68210239
5MP0005083_abnormal_biliary_tract3.63406025
6MP0005451_abnormal_body_composition3.47153449
7MP0005085_abnormal_gallbladder_physiolo3.44559066
8MP0009840_abnormal_foam_cell3.30125127
9MP0002837_dystrophic_cardiac_calcinosis2.90069614
10MP0003252_abnormal_bile_duct2.56759568
11MP0010329_abnormal_lipoprotein_level2.32443712
12MP0002909_abnormal_adrenal_gland2.28881829
13MP0008961_abnormal_basal_metabolism2.22877852
14MP0001666_abnormal_nutrient_absorption2.13505789
15MP0002877_abnormal_melanocyte_morpholog2.11680503
16MP0003806_abnormal_nucleotide_metabolis2.11344309
17MP0003300_gastrointestinal_ulcer2.02032188
18MP0005220_abnormal_exocrine_pancreas1.99478772
19MP0008875_abnormal_xenobiotic_pharmacok1.98438527
20MP0003191_abnormal_cellular_cholesterol1.96904244
21MP0003303_peritoneal_inflammation1.92803244
22MP0005076_abnormal_cell_differentiation1.91131071
23MP0003195_calcinosis1.89609983
24MP0003283_abnormal_digestive_organ1.85609452
25MP0003453_abnormal_keratinocyte_physiol1.80323832
26MP0001944_abnormal_pancreas_morphology1.77908221
27MP0000609_abnormal_liver_physiology1.77086384
28MP0003436_decreased_susceptibility_to1.71169617
29MP0003172_abnormal_lysosome_physiology1.65160144
30MP0004272_abnormal_basement_membrane1.64452473
31MP0008260_abnormal_autophagy1.63356449
32MP0002693_abnormal_pancreas_physiology1.63323244
33MP0005257_abnormal_intraocular_pressure1.56840133
34MP0002118_abnormal_lipid_homeostasis1.54273857
35MP0000858_altered_metastatic_potential1.54193233
36MP0005409_darkened_coat_color1.53383571
37MP0002078_abnormal_glucose_homeostasis1.52901623
38MP0003329_amyloid_beta_deposits1.49652086
39MP0002060_abnormal_skin_morphology1.48103985
40MP0009780_abnormal_chondrocyte_physiolo1.47028181
41MP0000733_abnormal_muscle_development1.42775447
42MP0003183_abnormal_peptide_metabolism1.37719280
43MP0003950_abnormal_plasma_membrane1.35498774
44MP0000003_abnormal_adipose_tissue1.34922693
45MP0005332_abnormal_amino_acid1.34873028
46MP0005319_abnormal_enzyme/_coenzyme1.33030866
47MP0009333_abnormal_splenocyte_physiolog1.32366855
48MP0005058_abnormal_lysosome_morphology1.32127129
49MP0001348_abnormal_lacrimal_gland1.32103167
50MP0000604_amyloidosis1.31395839
51MP0004130_abnormal_muscle_cell1.29767564
52MP0003868_abnormal_feces_composition1.28222486
53MP0000013_abnormal_adipose_tissue1.27658744
54MP0002269_muscular_atrophy1.27282644
55MP0004510_myositis1.26366742
56MP0006054_spinal_hemorrhage1.25948116
57MP0004858_abnormal_nervous_system1.25366214
58MP0004185_abnormal_adipocyte_glucose1.24898565
59MP0001958_emphysema1.23099248
60MP0002998_abnormal_bone_remodeling1.22115823
61MP0002138_abnormal_hepatobiliary_system1.20154080
62MP0008438_abnormal_cutaneous_collagen1.20080327
63MP0010234_abnormal_vibrissa_follicle1.18912563
64MP0002419_abnormal_innate_immunity1.18821698
65MP0001216_abnormal_epidermal_layer1.14964326
66MP0000598_abnormal_liver_morphology1.14899491
67MP0010368_abnormal_lymphatic_system1.14699546
68MP0009643_abnormal_urine_homeostasis1.12394659
69MP0003828_pulmonary_edema1.12158248
70MP0003763_abnormal_thymus_physiology1.12087578
71MP0010352_gastrointestinal_tract_polyps1.11806192
72MP0000750_abnormal_muscle_regeneration1.10171775
73MP0005025_abnormal_response_to1.08984821
74MP0005000_abnormal_immune_tolerance1.08668301
75MP0002796_impaired_skin_barrier1.07922529
76MP0002089_abnormal_postnatal_growth/wei1.07402928
77MP0005375_adipose_tissue_phenotype1.06545970
78MP0003959_abnormal_lean_body1.06304067
79MP0003566_abnormal_cell_adhesion1.06300317
80MP0000767_abnormal_smooth_muscle1.05515694
81MP0000751_myopathy1.04775173
82MP0002452_abnormal_antigen_presenting1.04318471
83MP0005584_abnormal_enzyme/coenzyme_acti1.02481656
84MP0005501_abnormal_skin_physiology1.02402282
85MP0004087_abnormal_muscle_fiber1.01378532
86MP0000685_abnormal_immune_system1.00309866
87MP0001835_abnormal_antigen_presentation0.98918923
88MP0002332_abnormal_exercise_endurance0.98101175
89MP0002928_abnormal_bile_duct0.95932325
90MP0002148_abnormal_hypersensitivity_rea0.95679998
91MP0002723_abnormal_immune_serum0.93961779
92MP0000678_abnormal_parathyroid_gland0.93497562
93MP0004233_abnormal_muscle_weight0.92148596
94MP0000467_abnormal_esophagus_morphology0.92139347
95MP0000343_altered_response_to0.91805496
96MP0001800_abnormal_humoral_immune0.91727750
97MP0002396_abnormal_hematopoietic_system0.91101847
98MP0001853_heart_inflammation0.89740199
99MP0010155_abnormal_intestine_physiology0.88569347
100MP0005023_abnormal_wound_healing0.88512204
101MP0001819_abnormal_immune_cell0.87157768
102MP0003075_altered_response_to0.86982794
103MP0002420_abnormal_adaptive_immunity0.86962895
104MP0001873_stomach_inflammation0.86524074
105MP0004808_abnormal_hematopoietic_stem0.85373953
106MP0002970_abnormal_white_adipose0.84333819
107MP0005621_abnormal_cell_physiology0.83391584
108MP0002933_joint_inflammation0.83130617
109MP0000747_muscle_weakness0.82786978
110MP0005666_abnormal_adipose_tissue0.82198888
111MP0005448_abnormal_energy_balance0.82048246
112MP0002405_respiratory_system_inflammati0.81890620
113MP0008469_abnormal_protein_level0.81124696
114MP0001243_abnormal_dermal_layer0.80312073
115MP0002234_abnormal_pharynx_morphology0.80264598
116MP0009672_abnormal_birth_weight0.80141080
117MP0009642_abnormal_blood_homeostasis0.80100911
118MP0009931_abnormal_skin_appearance0.79877624
119MP0005670_abnormal_white_adipose0.77741268
120MP0010630_abnormal_cardiac_muscle0.77497019
121MP0000759_abnormal_skeletal_muscle0.77201391
122MP0003656_abnormal_erythrocyte_physiolo0.77097443
123MP0003279_aneurysm0.77061603
124MP0005390_skeleton_phenotype0.76013689
125MP0009785_altered_susceptibility_to0.75868204
126MP0003448_altered_tumor_morphology0.75208924
127MP0005671_abnormal_response_to0.75085033
128MP0004947_skin_inflammation0.74941680
129MP0006036_abnormal_mitochondrial_physio0.72004354
130MP0005535_abnormal_body_temperature0.69326484
131MP0002971_abnormal_brown_adipose0.68940723
132MP0005330_cardiomyopathy0.68003071
133MP0000749_muscle_degeneration0.67419258
134MP0005464_abnormal_platelet_physiology0.66571609
135MP0004782_abnormal_surfactant_physiolog0.66091381
136MP0001533_abnormal_skeleton_physiology0.65653589
137MP0004264_abnormal_extraembryonic_tissu0.64944545
138MP0005387_immune_system_phenotype0.63885999
139MP0001790_abnormal_immune_system0.63885999
140MP0009278_abnormal_bone_marrow0.63168795
141MP0005334_abnormal_fat_pad0.61196316
142MP0003953_abnormal_hormone_level0.60912700
143MP0001845_abnormal_inflammatory_respons0.60680193
144MP0003091_abnormal_cell_migration0.60270247
145MP0004036_abnormal_muscle_relaxation0.60103623
146MP0001849_ear_inflammation0.58561859
147MP0009763_increased_sensitivity_to0.58391761
148MP0000358_abnormal_cell_content/0.57711181
149MP0005636_abnormal_mineral_homeostasis0.57538974
150MP0001765_abnormal_ion_homeostasis0.56805585

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.57403510
2Abnormality of aromatic amino acid family metabolism (HP:0004338)3.86349571
3Hypoglycemic coma (HP:0001325)3.70469373
4Xanthomatosis (HP:0000991)3.69207044
5Abnormality of monocarboxylic acid metabolism (HP:0010996)3.59942843
6Abnormality of the common coagulation pathway (HP:0010990)3.54645070
7Late onset (HP:0003584)3.45615056
8Ketoacidosis (HP:0001993)3.44042517
9Distal lower limb amyotrophy (HP:0008944)3.38642376
10Intrahepatic cholestasis (HP:0001406)3.35370177
11Abnormality of the intrinsic pathway (HP:0010989)3.33412253
12Hyperinsulinemic hypoglycemia (HP:0000825)3.29307389
13Ketosis (HP:0001946)3.26736850
14Premature rupture of membranes (HP:0001788)3.12401780
15Hypoglycemic seizures (HP:0002173)3.09269616
16Abnormality of glycolipid metabolism (HP:0010969)3.08834583
17Abnormality of liposaccharide metabolism (HP:0010968)3.08834583
18Abnormality of glycosphingolipid metabolism (HP:0004343)3.08834583
19Vertebral compression fractures (HP:0002953)3.07816921
20Distal lower limb muscle weakness (HP:0009053)3.05142045
21Broad face (HP:0000283)2.92250102
22Prolonged partial thromboplastin time (HP:0003645)2.89978951
23Complement deficiency (HP:0004431)2.82220038
24Abnormality of endocrine pancreas physiology (HP:0012093)2.80429160
25Abnormality of the pancreatic islet cells (HP:0006476)2.80429160
26Skin nodule (HP:0200036)2.73826929
27Joint hemorrhage (HP:0005261)2.67834335
28Hyperlipoproteinemia (HP:0010980)2.62387095
29J-shaped sella turcica (HP:0002680)2.56816571
30Hypobetalipoproteinemia (HP:0003563)2.56027923
31Urinary glycosaminoglycan excretion (HP:0003541)2.54894140
32Mucopolysacchariduria (HP:0008155)2.54894140
33Cerebral aneurysm (HP:0004944)2.52491590
34Myoglobinuria (HP:0002913)2.48528018
35Protrusio acetabuli (HP:0003179)2.45744719
36Gout (HP:0001997)2.45243657
37Rough bone trabeculation (HP:0100670)2.42855900
38Flat acetabular roof (HP:0003180)2.41211492
39Abnormality of complement system (HP:0005339)2.38459101
40Abnormality of the Achilles tendon (HP:0005109)2.38093416
41Fragile skin (HP:0001030)2.36185779
42Peritonitis (HP:0002586)2.35717453
43Interstitial pulmonary disease (HP:0006530)2.35066966
44Long toe (HP:0010511)2.33888199
45Spinal rigidity (HP:0003306)2.33705121
46Cervical subluxation (HP:0003308)2.32766231
47Back pain (HP:0003418)2.32373077
48Milia (HP:0001056)2.32091351
49Asymmetric septal hypertrophy (HP:0001670)2.31545001
50Atrophic scars (HP:0001075)2.31110088
51Abnormality of mucopolysaccharide metabolism (HP:0011020)2.29712526
52Abnormality of polysaccharide metabolism (HP:0011012)2.29712526
53Abnormality of glycosaminoglycan metabolism (HP:0004371)2.29712526
54Lower limb amyotrophy (HP:0007210)2.27920797
55Distal upper limb amyotrophy (HP:0007149)2.27577093
56Upper limb amyotrophy (HP:0009129)2.27577093
57Hyperammonemia (HP:0001987)2.27314640
58Mitral stenosis (HP:0001718)2.27144771
59Centrally nucleated skeletal muscle fibers (HP:0003687)2.25103129
60Generalized amyotrophy (HP:0003700)2.23449172
61Hand muscle atrophy (HP:0009130)2.22211314
62Dysostosis multiplex (HP:0000943)2.21994534
63Myocardial infarction (HP:0001658)2.21041084
64Obstructive sleep apnea (HP:0002870)2.18168782
65Pancreatic islet-cell hyperplasia (HP:0004510)2.17176236
66Hypercortisolism (HP:0001578)2.14636078
67Short nail (HP:0001799)2.14198583
68Increased variability in muscle fiber diameter (HP:0003557)2.14075625
69Abnormal gallbladder morphology (HP:0012437)2.13761337
70Achilles tendon contracture (HP:0001771)2.13255152
71Aortic regurgitation (HP:0001659)2.12892456
72Mildly elevated creatine phosphokinase (HP:0008180)2.11417022
73Symptomatic seizures (HP:0011145)2.10713523
74Axonal loss (HP:0003447)2.10511411
75Hyperglycemia (HP:0003074)2.09793856
76Abnormality of skeletal muscle fiber size (HP:0012084)2.09255168
77Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.09095003
78Aneurysm (HP:0002617)2.07727117
79Global brain atrophy (HP:0002283)2.06531250
80Cholelithiasis (HP:0001081)2.05893575
81Hypolipoproteinemia (HP:0010981)2.05717406
82Type 1 muscle fiber predominance (HP:0003803)2.05590494
83Oral leukoplakia (HP:0002745)2.04594345
84Ankle contracture (HP:0006466)2.03420631
85Abnormality of sulfur amino acid metabolism (HP:0004339)2.02433655
86Lymphangioma (HP:0100764)2.02173493
87Spastic diplegia (HP:0001264)2.02051217
88Hypoalphalipoproteinemia (HP:0003233)2.00932225
89Deformed sella turcica (HP:0002681)2.00257430
90Hyperbilirubinemia (HP:0002904)2.00046440
91Abnormality of the thoracic spine (HP:0100711)2.00040383
92Elbow flexion contracture (HP:0002987)1.98768526
93Natal tooth (HP:0000695)1.98544868
94Ulnar bowing (HP:0003031)1.98296013
95Reduced subcutaneous adipose tissue (HP:0003758)1.98243863
96Increased cerebral lipofuscin (HP:0011813)1.97251041
97Epidermoid cyst (HP:0200040)1.96575475
98Death in childhood (HP:0003819)1.96066677
99Polycythemia (HP:0001901)1.95634162
100Osteolytic defects of the phalanges of the hand (HP:0009771)1.95503701
101Osteolytic defects of the hand bones (HP:0009699)1.95503701
102Hemorrhage of the eye (HP:0011885)1.94969031
103Pathologic fracture (HP:0002756)1.94356554
104Large for gestational age (HP:0001520)1.93771114
105Thoracic kyphosis (HP:0002942)1.91777585
106Persistence of primary teeth (HP:0006335)1.91367712
107Insulin resistance (HP:0000855)1.91235365
108Hyperacusis (HP:0010780)1.90060189
109Abnormality of the distal phalanges of the toes (HP:0010182)1.89421211
110Progressive muscle weakness (HP:0003323)1.88948249
111Abnormal trabecular bone morphology (HP:0100671)1.88692554
112Abnormality of purine metabolism (HP:0004352)1.86902523
113Reticulocytosis (HP:0001923)1.86508840
114Abnormality of the lower motor neuron (HP:0002366)1.85313394
115Mitral regurgitation (HP:0001653)1.84940143
116Insomnia (HP:0100785)1.84361871
117Abnormality of the odontoid process (HP:0003310)1.83306623
118Fat malabsorption (HP:0002630)1.83285382
119Neonatal onset (HP:0003623)1.83067383
120Multiple lipomas (HP:0001012)1.82812900
121Increased serum ferritin (HP:0003281)1.81990167
122Ridged nail (HP:0001807)1.81443276
123Upper motor neuron abnormality (HP:0002127)1.80642927
124Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.80064042
125Increased neuronal autofluorescent lipopigment (HP:0002074)1.79759252
126Shallow orbits (HP:0000586)1.79708392
127Increased connective tissue (HP:0009025)1.78987168
128Thick nail (HP:0001805)1.77562653
129Joint stiffness (HP:0001387)1.75702197
130Thoracolumbar scoliosis (HP:0002944)1.75252534
131Protuberant abdomen (HP:0001538)1.75092582
132Limb-girdle muscle atrophy (HP:0003797)1.74861023
133Recurrent gram-negative bacterial infections (HP:0005420)1.74768011
134Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.73753279
135Tachypnea (HP:0002789)1.73676641
136Spondylolisthesis (HP:0003302)1.73272677
137Sudden death (HP:0001699)1.72787071
138Nail dystrophy (HP:0008404)1.72593074
139Short femoral neck (HP:0100864)1.72196978
140Arterial tortuosity (HP:0005116)1.70348257
141Trismus (HP:0000211)1.68940820
142Abnormality of nucleobase metabolism (HP:0010932)1.68846438
143Papilledema (HP:0001085)1.68771679
144Wormian bones (HP:0002645)1.67863268
145Bladder diverticulum (HP:0000015)1.67780411
146Agitation (HP:0000713)1.67567754
147Abnormality of macrophages (HP:0004311)1.67009472
148Esophageal varix (HP:0002040)1.67000190
149Nuclear cataract (HP:0100018)1.66458438
150Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.65492535
151Blue sclerae (HP:0000592)1.65364470
152Myopathic facies (HP:0002058)1.64989853
153Vascular tortuosity (HP:0004948)1.64373418
154Bowed forearm bones (HP:0003956)1.63715726
155Bowing of the arm (HP:0006488)1.63715726
156Spinal cord lesions (HP:0100561)1.63664390
157Syringomyelia (HP:0003396)1.63664390
158Dilatation of the ascending aorta (HP:0005111)1.63532678
159Ragged-red muscle fibers (HP:0003200)1.62942820
160Eczematoid dermatitis (HP:0000976)1.62828478
161Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.62490716
162Abnormal ossification of hand bones (HP:0005921)1.62460116
163Neoplasm of the heart (HP:0100544)1.62177922
164Polygenic inheritance (HP:0010982)1.62090833
165Mitral valve prolapse (HP:0001634)1.61977682
166Difficulty climbing stairs (HP:0003551)1.61907184
167Thin bony cortex (HP:0002753)1.61333539
168Disproportionate tall stature (HP:0001519)1.60993458
169Striae distensae (HP:0001065)1.60539746
170Athetosis (HP:0002305)1.60182257
171Abnormality of the gallbladder (HP:0005264)1.60154980
172Abnormality of glutamine family amino acid metabolism (HP:0010902)1.60043992
173Exercise-induced myalgia (HP:0003738)1.58800773
174Hamartoma of the eye (HP:0010568)1.58551847
175Ventricular tachycardia (HP:0004756)1.58551530
176Cerebral inclusion bodies (HP:0100314)1.57434015
177Menorrhagia (HP:0000132)1.57256582
178Turricephaly (HP:0000262)1.56304793

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.57017539
2ERN15.13710958
3PKN24.38361416
4IRAK33.48201876
5PRPF4B2.97010207
6EEF2K2.96703404
7SMG12.95121035
8NME22.56607346
9BCKDK2.56001064
10MAP3K102.46147743
11EPHA22.40062194
12TTN2.30071794
13MST1R2.25755549
14BLK2.18975603
15PTK62.09028778
16SIK11.99551438
17MAP4K11.95071947
18TAOK31.93087179
19FGFR41.73436235
20PASK1.65893527
21PDGFRA1.64499121
22FLT31.59024756
23TAOK21.48635327
24RIPK11.45815361
25TYK21.44141969
26SCYL21.42360337
27PRKD31.41241179
28HIPK21.34005129
29GRK61.32247026
30MAP3K141.28687783
31MAP3K31.28622727
32TBK11.25276984
33INSRR1.22334565
34CDK121.19834081
35MAPKAPK31.18266844
36PIM21.16287561
37TESK11.15342168
38PRKCH1.14274370
39RET1.13009376
40LIMK11.10655945
41ZAP701.08958624
42LRRK21.06375474
43TAOK11.05911021
44MOS1.05509496
45MAP3K11.03553665
46MAP3K131.03161791
47KSR21.03061347
48MAP2K31.01340092
49NEK91.00930500
50TGFBR21.00031122
51ALK0.99848334
52IRAK40.99642865
53BMX0.97805952
54MTOR0.96786190
55ICK0.95459998
56CAMKK10.91584445
57JAK20.91544731
58MET0.91388956
59PTK20.90890413
60SIK20.90434275
61MAP3K110.89456686
62MAP3K70.88745574
63MAPK150.88686497
64TLK10.87875088
65ARAF0.87178463
66JAK30.84807411
67UHMK10.84583309
68NTRK10.81777812
69JAK10.80024067
70KDR0.78959383
71MAP3K20.76662917
72RPS6KA20.74612557
73DAPK20.74396408
74MAPK110.74258931
75NEK10.72182956
76LATS20.70723355
77MELK0.69907563
78DYRK1B0.69421145
79DAPK10.63713696
80MAP2K20.60993442
81EPHB10.60725238
82MAP3K60.60722916
83CDK80.60710744
84TRPM70.60467910
85MARK20.60036902
86MAPK120.59705740
87DDR20.58621005
88CDK90.55965698
89RPS6KA40.55758437
90PAK40.54071169
91MAPK70.53748271
92WNK30.53379866
93MAPKAPK20.53174822
94PRKD10.52721712
95CDC42BPA0.52330415
96SIK30.52060390
97IKBKB0.51603561
98BRSK10.51065512
99ERBB40.50973171
100PAK60.50106454
101MAP3K80.50063698
102MAP2K40.49970008
103CAMK1G0.49598224
104PDPK10.49567346
105AURKA0.49217613
106PRKD20.48669892
107RPS6KC10.47430369
108RPS6KL10.47430369
109BRAF0.47269338
110PDGFRB0.46317370
111RPS6KA60.45100948
112BTK0.45084943
113STK100.44483538
114ITK0.43820478
115SYK0.42832895
116CDK70.42421943
117PAK20.42407671
118CSK0.41549357
119GRK70.41429439
120CDK60.40592131
121RIPK40.40239567
122PDK10.40164356
123PRKG20.39885188
124CLK10.39793371
125LMTK20.39708236
126EPHB20.39639457
127CHUK0.39492012
128ILK0.39387576
129DAPK30.38698320
130ABL20.38591561
131HCK0.38482764
132RPS6KA10.37037130
133CDK40.35192521
134CAMK1D0.34929967
135FES0.32442569
136CSF1R0.31512985
137NEK20.30750839
138EGFR0.29919828
139PIK3CG0.29667213
140MAP2K10.29464445
141PAK30.27931578
142TESK20.27738155
143ERBB20.27569175

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.55482355
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.63848200
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.16290852
4Nitrogen metabolism_Homo sapiens_hsa009102.98564417
5Other glycan degradation_Homo sapiens_hsa005112.94016422
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.43620091
7Arginine biosynthesis_Homo sapiens_hsa002202.43484107
8Tryptophan metabolism_Homo sapiens_hsa003802.39881597
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.38105773
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.35365409
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.18460622
12Fatty acid degradation_Homo sapiens_hsa000712.12091008
13Selenocompound metabolism_Homo sapiens_hsa004501.98332091
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.96067943
15Complement and coagulation cascades_Homo sapiens_hsa046101.86379536
16Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.60929123
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.57288067
18TNF signaling pathway_Homo sapiens_hsa046681.56005155
19Biosynthesis of amino acids_Homo sapiens_hsa012301.51496118
20Carbon metabolism_Homo sapiens_hsa012001.50843689
21Pancreatic cancer_Homo sapiens_hsa052121.48574847
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.48274954
23Butanoate metabolism_Homo sapiens_hsa006501.47193376
24Viral carcinogenesis_Homo sapiens_hsa052031.46319250
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.45371341
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.41528981
27Insulin resistance_Homo sapiens_hsa049311.40346576
28Systemic lupus erythematosus_Homo sapiens_hsa053221.39808463
29Small cell lung cancer_Homo sapiens_hsa052221.39294145
30Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.36878264
31Fat digestion and absorption_Homo sapiens_hsa049751.33869665
32Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.33403516
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.33339204
34Apoptosis_Homo sapiens_hsa042101.33104681
35Toxoplasmosis_Homo sapiens_hsa051451.33088576
36Fatty acid metabolism_Homo sapiens_hsa012121.29582443
37Lysine degradation_Homo sapiens_hsa003101.29132861
38Bile secretion_Homo sapiens_hsa049761.28938557
39Focal adhesion_Homo sapiens_hsa045101.27210691
40Starch and sucrose metabolism_Homo sapiens_hsa005001.21681475
41Hepatitis B_Homo sapiens_hsa051611.21675218
42AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.21490908
43Shigellosis_Homo sapiens_hsa051311.18615489
44Phenylalanine metabolism_Homo sapiens_hsa003601.18357520
45Notch signaling pathway_Homo sapiens_hsa043301.18104800
46PPAR signaling pathway_Homo sapiens_hsa033201.18101384
47Staphylococcus aureus infection_Homo sapiens_hsa051501.17286146
48Type II diabetes mellitus_Homo sapiens_hsa049301.15805547
49Influenza A_Homo sapiens_hsa051641.13450613
50Hepatitis C_Homo sapiens_hsa051601.12236229
51Drug metabolism - other enzymes_Homo sapiens_hsa009831.11202223
52Glucagon signaling pathway_Homo sapiens_hsa049221.08839662
53Propanoate metabolism_Homo sapiens_hsa006401.08341903
54Sulfur metabolism_Homo sapiens_hsa009201.05782828
55Prion diseases_Homo sapiens_hsa050201.03510752
56Tuberculosis_Homo sapiens_hsa051521.02040629
57Adipocytokine signaling pathway_Homo sapiens_hsa049201.01464413
58ABC transporters_Homo sapiens_hsa020101.00477072
59Proteoglycans in cancer_Homo sapiens_hsa052050.99336524
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.99312059
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.99303227
62Sulfur relay system_Homo sapiens_hsa041220.98702554
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.97234872
64Pyruvate metabolism_Homo sapiens_hsa006200.96512864
65HTLV-I infection_Homo sapiens_hsa051660.94860238
66Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94674237
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94352804
68Renal cell carcinoma_Homo sapiens_hsa052110.92728132
69Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91901257
70Insulin secretion_Homo sapiens_hsa049110.91171467
71T cell receptor signaling pathway_Homo sapiens_hsa046600.91128646
72Measles_Homo sapiens_hsa051620.88932229
73Herpes simplex infection_Homo sapiens_hsa051680.87596996
74ECM-receptor interaction_Homo sapiens_hsa045120.87411458
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.85275913
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.84457022
77GnRH signaling pathway_Homo sapiens_hsa049120.84254751
78Insulin signaling pathway_Homo sapiens_hsa049100.83406367
79Viral myocarditis_Homo sapiens_hsa054160.83043218
80One carbon pool by folate_Homo sapiens_hsa006700.81574504
81mTOR signaling pathway_Homo sapiens_hsa041500.80679220
82Salmonella infection_Homo sapiens_hsa051320.80597984
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79763341
84Peroxisome_Homo sapiens_hsa041460.79077845
85beta-Alanine metabolism_Homo sapiens_hsa004100.77966625
86Endocytosis_Homo sapiens_hsa041440.77644439
87MicroRNAs in cancer_Homo sapiens_hsa052060.77474216
88Glycosaminoglycan degradation_Homo sapiens_hsa005310.77059714
89Leukocyte transendothelial migration_Homo sapiens_hsa046700.75340689
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.74477551
91Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.73341960
92Histidine metabolism_Homo sapiens_hsa003400.72654156
93Prostate cancer_Homo sapiens_hsa052150.72198283
94Malaria_Homo sapiens_hsa051440.72023669
95Chronic myeloid leukemia_Homo sapiens_hsa052200.71081549
96Endometrial cancer_Homo sapiens_hsa052130.71033692
97ErbB signaling pathway_Homo sapiens_hsa040120.70115146
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69273634
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.69075941
100Intestinal immune network for IgA production_Homo sapiens_hsa046720.68530931
101Bladder cancer_Homo sapiens_hsa052190.68222282
102Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.68207862
103Galactose metabolism_Homo sapiens_hsa000520.67180247
104Caffeine metabolism_Homo sapiens_hsa002320.66119863
105Pentose phosphate pathway_Homo sapiens_hsa000300.63835725
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.63488460
107AMPK signaling pathway_Homo sapiens_hsa041520.62950946
108Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62415816
109Epstein-Barr virus infection_Homo sapiens_hsa051690.61274124
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.59981540
111VEGF signaling pathway_Homo sapiens_hsa043700.58885316
112Lysosome_Homo sapiens_hsa041420.57546816
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57428258
114Pancreatic secretion_Homo sapiens_hsa049720.56806182
115Jak-STAT signaling pathway_Homo sapiens_hsa046300.56553544
116Alcoholism_Homo sapiens_hsa050340.53842198
117Tyrosine metabolism_Homo sapiens_hsa003500.53488458
118Folate biosynthesis_Homo sapiens_hsa007900.52754900
119Platelet activation_Homo sapiens_hsa046110.52372827
120Hematopoietic cell lineage_Homo sapiens_hsa046400.52068523
121Estrogen signaling pathway_Homo sapiens_hsa049150.51490297
122Arginine and proline metabolism_Homo sapiens_hsa003300.51067744
123Melanoma_Homo sapiens_hsa052180.50947294
124Acute myeloid leukemia_Homo sapiens_hsa052210.49931999
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49019296
126Pathways in cancer_Homo sapiens_hsa052000.48510100
127MAPK signaling pathway_Homo sapiens_hsa040100.48507251
128Glycerolipid metabolism_Homo sapiens_hsa005610.48001096
129Prolactin signaling pathway_Homo sapiens_hsa049170.47900529
130Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47001270
131Non-small cell lung cancer_Homo sapiens_hsa052230.45082902
132Glioma_Homo sapiens_hsa052140.44764471
133Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44706003
134B cell receptor signaling pathway_Homo sapiens_hsa046620.44543768
135Fructose and mannose metabolism_Homo sapiens_hsa000510.44350012
136Aldosterone synthesis and secretion_Homo sapiens_hsa049250.44313694
137Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.43945328
138N-Glycan biosynthesis_Homo sapiens_hsa005100.41801918
139Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41134971
140Leishmaniasis_Homo sapiens_hsa051400.40509976
141Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.39176621
142Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.38091813
143Thyroid hormone synthesis_Homo sapiens_hsa049180.34169364
144Cocaine addiction_Homo sapiens_hsa050300.31582407
145Osteoclast differentiation_Homo sapiens_hsa043800.26620130
146Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.26021540
147Type I diabetes mellitus_Homo sapiens_hsa049400.25628689
148Pertussis_Homo sapiens_hsa051330.25513580
149Dilated cardiomyopathy_Homo sapiens_hsa054140.24583869
150Thyroid cancer_Homo sapiens_hsa052160.24210593
151Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23386463
152Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.21883148
153Amoebiasis_Homo sapiens_hsa051460.19605973

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