DPP7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. The resting lymphocytes are maintained through suppression of apoptosis, a state which is disrupted by inhibition of this novel serine protease. The enzyme has strong sequence homology with prolylcarboxypeptidase and is active at both acidic and neutral pH. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.51932619
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.51932619
3positive regulation by organism of defense response of other organism involved in symbiotic interact5.51932619
4modulation by symbiont of host immune response (GO:0052553)5.51932619
5positive regulation by symbiont of host defense response (GO:0052509)5.51932619
6modulation by symbiont of host defense response (GO:0052031)5.51932619
7negative regulation of erythrocyte differentiation (GO:0045647)4.83483981
8macrophage activation involved in immune response (GO:0002281)4.20337784
9regulation of interferon-beta biosynthetic process (GO:0045357)4.07253525
10positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.05544876
11neutrophil activation involved in immune response (GO:0002283)4.04816762
12positive regulation of gamma-delta T cell activation (GO:0046645)4.02173331
13basic amino acid transport (GO:0015802)3.91698075
14L-alpha-amino acid transmembrane transport (GO:1902475)3.88685743
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.63366606
16NIK/NF-kappaB signaling (GO:0038061)3.58145262
17antigen processing and presentation of endogenous antigen (GO:0019883)3.57795323
18response to peptidoglycan (GO:0032494)3.56655126
19mannose metabolic process (GO:0006013)3.55754151
20positive regulation of interferon-alpha production (GO:0032727)3.50035580
21negative regulation of cell killing (GO:0031342)3.49366172
22negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.49366172
23phagosome maturation (GO:0090382)3.45587160
24antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.42321524
25response to muramyl dipeptide (GO:0032495)3.38606909
26detection of molecule of bacterial origin (GO:0032490)3.36164371
27hydrogen peroxide biosynthetic process (GO:0050665)3.35693291
28microglial cell activation (GO:0001774)3.33205106
29glycoside metabolic process (GO:0016137)3.31841580
30keratan sulfate catabolic process (GO:0042340)3.31766513
31cellular response to thyroid hormone stimulus (GO:0097067)3.28812982
32regulation of interferon-alpha production (GO:0032647)3.26683289
33mature B cell differentiation involved in immune response (GO:0002313)3.24140367
34aldehyde catabolic process (GO:0046185)3.23938217
35regulation of cholesterol storage (GO:0010885)3.21243569
36barbed-end actin filament capping (GO:0051016)3.19123721
37response to host immune response (GO:0052572)3.18382365
38response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.18382365
39apoptotic cell clearance (GO:0043277)3.17528088
40low-density lipoprotein particle clearance (GO:0034383)3.14935940
41positive thymic T cell selection (GO:0045059)3.14792149
42respiratory burst (GO:0045730)3.14146471
43macroautophagy (GO:0016236)3.13764338
44folic acid transport (GO:0015884)3.11172679
45positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.08807809
46regulation of mast cell degranulation (GO:0043304)3.00542002
47regulation of gamma-delta T cell activation (GO:0046643)2.99686241
48germinal center formation (GO:0002467)2.98454293
49regulation of leukocyte degranulation (GO:0043300)2.94923361
50macrophage activation (GO:0042116)2.94710992
51negative regulation of interleukin-12 production (GO:0032695)2.94682277
52negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.92072900
53transferrin transport (GO:0033572)2.92032435
54Golgi transport vesicle coating (GO:0048200)2.89989636
55COPI coating of Golgi vesicle (GO:0048205)2.89989636
56amyloid precursor protein catabolic process (GO:0042987)2.88926491
57ATP hydrolysis coupled proton transport (GO:0015991)2.88336849
58energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.88336849
59intracellular pH reduction (GO:0051452)2.88165325
60detection of bacterium (GO:0016045)2.87879121
61antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.87446387
62immunoglobulin mediated immune response (GO:0016064)2.86548197
63reactive oxygen species biosynthetic process (GO:1903409)2.86437097
64modulation by symbiont of host cellular process (GO:0044068)2.85531278
65response to thyroid hormone (GO:0097066)2.85215712
66regulation of gamma-delta T cell differentiation (GO:0045586)2.84583621
67amino sugar catabolic process (GO:0046348)2.84383397
68positive regulation of interferon-beta production (GO:0032728)2.82893351
69detection of other organism (GO:0098543)2.81555565
70glycolipid catabolic process (GO:0019377)2.80469952
71thymic T cell selection (GO:0045061)2.80298649
72plasma lipoprotein particle clearance (GO:0034381)2.80108980
73glycosphingolipid catabolic process (GO:0046479)2.80076937
74regulation of mononuclear cell migration (GO:0071675)2.79534276
75regulation of myeloid leukocyte mediated immunity (GO:0002886)2.78664304
76erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.77866320
77L-phenylalanine metabolic process (GO:0006558)2.77866320
78positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.77685480
79pH reduction (GO:0045851)2.77119759
80urate metabolic process (GO:0046415)2.76602104
81positive regulation of B cell differentiation (GO:0045579)2.75800400
82ferric iron transport (GO:0015682)2.75612174
83trivalent inorganic cation transport (GO:0072512)2.75612174
84Arp2/3 complex-mediated actin nucleation (GO:0034314)2.74513166
85type I interferon signaling pathway (GO:0060337)2.74081941
86cellular response to type I interferon (GO:0071357)2.74081941
87response to type I interferon (GO:0034340)2.73727942
88pinocytosis (GO:0006907)2.73549216
89negative regulation of lipid storage (GO:0010888)2.71703461
90protein localization to endosome (GO:0036010)2.71699391
91protein carboxylation (GO:0018214)2.71658950
92peptidyl-glutamic acid carboxylation (GO:0017187)2.71658950
93response to lipoprotein particle (GO:0055094)2.71503116
94cysteine metabolic process (GO:0006534)2.68843630
95positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.68588111
96response to host (GO:0075136)2.66092430
97response to host defenses (GO:0052200)2.66092430
98response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.66092430
99L-ascorbic acid metabolic process (GO:0019852)2.64803684
100positive regulation of antigen processing and presentation (GO:0002579)2.64713404
101modulation by virus of host process (GO:0019054)2.64436551
102myeloid dendritic cell differentiation (GO:0043011)2.62838627
103regulation of type I interferon-mediated signaling pathway (GO:0060338)2.61575261
104positive regulation of leukocyte degranulation (GO:0043302)2.61111523
105I-kappaB phosphorylation (GO:0007252)2.60918616
106interferon-gamma-mediated signaling pathway (GO:0060333)2.60493310
107L-phenylalanine catabolic process (GO:0006559)2.60174924
108erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.60174924
109regulation of mast cell activation involved in immune response (GO:0033006)2.59857290
110positive regulation of chemokine biosynthetic process (GO:0045080)2.59730123
111regulation of antigen processing and presentation (GO:0002577)2.59185251
112regulation of superoxide anion generation (GO:0032928)2.58685672
113natural killer cell mediated cytotoxicity (GO:0042267)2.56890968
114natural killer cell mediated immunity (GO:0002228)2.56890968
115positive regulation of bone resorption (GO:0045780)2.56812597
116positive regulation of bone remodeling (GO:0046852)2.56812597
117lipoprotein transport (GO:0042953)2.56410388
118myeloid cell activation involved in immune response (GO:0002275)2.56011349
119activation of MAPKKK activity (GO:0000185)2.55594046
120positive regulation of cellular amide metabolic process (GO:0034250)2.54648454
121positive regulation of lymphocyte apoptotic process (GO:0070230)2.52677969
122phospholipid homeostasis (GO:0055091)2.52275496
123regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.51740223
124wound healing, spreading of epidermal cells (GO:0035313)2.51399988
125sulfur amino acid catabolic process (GO:0000098)2.51330419
126T cell selection (GO:0045058)2.50834274
127regulation of dendritic cell antigen processing and presentation (GO:0002604)2.50692386
128lipopolysaccharide-mediated signaling pathway (GO:0031663)2.50390292
129glyoxylate metabolic process (GO:0046487)2.49966927
130response to protozoan (GO:0001562)2.49737873
131negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.48940238
132negative regulation of cytokine production involved in immune response (GO:0002719)2.48692083
133negative regulation of innate immune response (GO:0045824)2.47716773
134negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.47677590
135regulation of monocyte differentiation (GO:0045655)2.47666864
136folic acid metabolic process (GO:0046655)2.46805866
137homocysteine metabolic process (GO:0050667)2.46714207
138regulation of membrane protein ectodomain proteolysis (GO:0051043)2.46471140
139cofactor catabolic process (GO:0051187)2.45505337
140eosinophil chemotaxis (GO:0048245)2.45100206
141myeloid dendritic cell activation (GO:0001773)2.45067003
142detection of external biotic stimulus (GO:0098581)2.44973885
143regulation of interleukin-8 biosynthetic process (GO:0045414)2.44344358
144defense response to protozoan (GO:0042832)2.44195027
145purine nucleotide salvage (GO:0032261)2.44060938
146regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)2.43566822
147regulation of integrin activation (GO:0033623)2.43323896
148modified amino acid transport (GO:0072337)2.42706528
149leukocyte aggregation (GO:0070486)2.42679985
150regulation of complement activation (GO:0030449)2.42543311
151ceramide catabolic process (GO:0046514)2.41269386
152regulation of hydrogen peroxide-induced cell death (GO:1903205)2.41047382
153regulation of necrotic cell death (GO:0010939)2.40299419
154regulation of defense response to virus by virus (GO:0050690)2.40198624
155regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.40032111
156glycosylceramide metabolic process (GO:0006677)2.39971776
157positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.39149859
158negative regulation of granulocyte differentiation (GO:0030853)2.38790633
159negative regulation of nitric oxide biosynthetic process (GO:0045019)2.38579640
160T cell migration (GO:0072678)2.38469064
161regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.38403910
162negative regulation of cell size (GO:0045792)2.38279649
163regulation of tumor necrosis factor production (GO:0032680)2.37951939
164granulocyte activation (GO:0036230)2.37166279
165positive regulation of Cdc42 GTPase activity (GO:0043089)2.36550675
166negative regulation of myeloid cell apoptotic process (GO:0033033)2.36306787
167oligosaccharide catabolic process (GO:0009313)2.35744307
168tumor necrosis factor-mediated signaling pathway (GO:0033209)2.35217022
169mature B cell differentiation (GO:0002335)2.35094857
170regulation of regulated secretory pathway (GO:1903305)2.34594241
171regulation of T-helper 2 cell differentiation (GO:0045628)2.33471883
172negative thymic T cell selection (GO:0045060)2.32418295
173regulation of interleukin-2 biosynthetic process (GO:0045076)2.30893848
174tolerance induction (GO:0002507)2.30650718
175epithelial cell differentiation involved in prostate gland development (GO:0060742)2.30146864
176adhesion of symbiont to host (GO:0044406)2.29772718
177negative regulation of tumor necrosis factor production (GO:0032720)2.29755583

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse4.85160918
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.03507307
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.96998304
4VDR_21846776_ChIP-Seq_THP-1_Human3.27122619
5Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.12357171
6RXR_22158963_ChIP-Seq_LIVER_Mouse2.98584120
7IRF8_27001747_Chip-Seq_BMDM_Mouse2.93920829
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.89693596
9TFEB_21752829_ChIP-Seq_HELA_Human2.71655305
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.71016131
11MYC_22102868_ChIP-Seq_BL_Human2.60304686
12* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.54966968
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.48150498
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.41300316
15KDM2B_26808549_Chip-Seq_SUP-B15_Human2.36342969
16CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.26629454
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.25001488
18LXR_22158963_ChIP-Seq_LIVER_Mouse2.24289483
19VDR_24763502_ChIP-Seq_THP-1_Human2.23078562
20KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.22493968
21CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.16880496
22TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.06179817
23KDM2B_26808549_Chip-Seq_DND41_Human2.03134711
24TCF7_22412390_ChIP-Seq_EML_Mouse2.02506394
25RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.98832759
26MYB_21317192_ChIP-Seq_ERMYB_Mouse1.95845828
27MAF_26560356_Chip-Seq_TH1_Human1.87325543
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.84928811
29PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.79736360
30STAT3_1855785_ChIP-Seq_MESCs_Mouse1.79282405
31FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.77825376
32STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.76616747
33EGR1_23403033_ChIP-Seq_LIVER_Mouse1.72280856
34PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.70727036
35MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.69420841
36UTX_26944678_Chip-Seq_JUKART_Human1.67466221
37ESR1_21235772_ChIP-Seq_MCF-7_Human1.66193199
38MAF_26560356_Chip-Seq_TH2_Human1.65486829
39SCL_19346495_ChIP-Seq_HPC-7_Human1.63621077
40IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.63029998
41TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62776999
42P68_20966046_ChIP-Seq_HELA_Human1.61627007
43BRD4_27068464_Chip-Seq_AML-cells_Mouse1.60355313
44POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.59233887
45THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54987479
46SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.54311900
47ELF1_20517297_ChIP-Seq_JURKAT_Human1.53259834
48STAT4_19710469_ChIP-ChIP_TH1__Mouse1.51799793
49CTCF_27219007_Chip-Seq_ERYTHROID_Human1.50791657
50SPI1_23547873_ChIP-Seq_NB4_Human1.49313494
51CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.49228924
52SRY_22984422_ChIP-ChIP_TESTIS_Rat1.48316868
53SA1_27219007_Chip-Seq_ERYTHROID_Human1.47332430
54KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.46137154
55TET1_21451524_ChIP-Seq_MESCs_Mouse1.45049548
56BCL6_27268052_Chip-Seq_Bcells_Human1.44522328
57* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.42578464
58BCOR_27268052_Chip-Seq_Bcells_Human1.41747843
59TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.40661015
60CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39682808
61STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.39113717
62SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.36336194
63KDM2B_26808549_Chip-Seq_K562_Human1.35904843
64PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.35715346
65VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.35107360
66GATA1_22383799_ChIP-Seq_G1ME_Mouse1.33622099
67SMC4_20622854_ChIP-Seq_HELA_Human1.32946361
68CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32227419
69GATA1_19941827_ChIP-Seq_MEL_Mouse1.32072002
70CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.31491895
71NCOR1_26117541_ChIP-Seq_K562_Human1.29915159
72NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.28321895
73KDM2B_26808549_Chip-Seq_JURKAT_Human1.27862122
74NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.27859947
75* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.26976883
76KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.25496054
77SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.25047788
78TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24914799
79HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.23560435
80ZNF263_19887448_ChIP-Seq_K562_Human1.22703398
81PU.1_20513432_ChIP-Seq_Bcells_Mouse1.21433627
82EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21392852
83UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.20802033
84TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.19975814
85CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.19960261
86FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19416182
87TP63_17297297_ChIP-ChIP_HaCaT_Human1.19391673
88PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19083004
89EGR1_19374776_ChIP-ChIP_THP-1_Human1.18755877
90SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17639027
91KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.17056179
92KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.17056179
93KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.17056179
94NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.16761117
95GATA1_19941826_ChIP-Seq_K562_Human1.16550334
96* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.16522935
97RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.16493186
98DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15317992
99SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14733558
100ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.14713536
101CTCF_26484167_Chip-Seq_Bcells_Mouse1.14619032
102EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.14588671
103NANOG_18555785_ChIP-Seq_MESCs_Mouse1.14259999
104DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.14070019
105LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.13908156
106GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.13867652
107ERG_21242973_ChIP-ChIP_JURKAT_Human1.13206870
108SPI1_23127762_ChIP-Seq_K562_Human1.12318426
109PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.12235251
110CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11566198
111SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.10836498
112TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10620223
113GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10423674
114KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10419711
115STAT6_21828071_ChIP-Seq_BEAS2B_Human1.10209979
116PU_27001747_Chip-Seq_BMDM_Mouse1.09799608
117* LXR_22292898_ChIP-Seq_THP-1_Human1.09632814
118MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.09294735
119TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07246600
120CREB1_15753290_ChIP-ChIP_HEK293T_Human1.06486243
121RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.06478205
122CREB1_26743006_Chip-Seq_LNCaP_Human1.05908582
123KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.05758785
124* CLOCK_20551151_ChIP-Seq_293T_Human1.04618703
125ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04527407
126CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.04517937
127IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.04513906
128SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03012069
129GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02408868
130MYB_26560356_Chip-Seq_TH1_Human1.02304186
131ESR2_21235772_ChIP-Seq_MCF-7_Human1.01160334
132SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.01156169
133SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.99137075
134GABP_17652178_ChIP-ChIP_JURKAT_Human0.99051924
135HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97275721
136ELK3_25401928_ChIP-Seq_HUVEC_Human0.97128390
137SRF_21415370_ChIP-Seq_HL-1_Mouse0.97092685
138TRIM28_21343339_ChIP-Seq_HEK293_Human0.96562743
139SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96212480
140* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.95258883
141ETS1_20019798_ChIP-Seq_JURKAT_Human0.95051713
142DCP1A_22483619_ChIP-Seq_HELA_Human0.93916739
143SALL4_18804426_ChIP-ChIP_XEN_Mouse0.93519830
144PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.93326872
145PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93204861
146ATF3_27146783_Chip-Seq_COLON_Human0.92819689
147NRF2_20460467_ChIP-Seq_MEFs_Mouse0.89796136
148NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.89796136
149TCF3_18692474_ChIP-Seq_MEFs_Mouse0.89468320
150EST1_17652178_ChIP-ChIP_JURKAT_Human0.88126249
151RUNX1_22412390_ChIP-Seq_EML_Mouse0.86929503
152MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.86682965
153NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.86483461
154PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.86000469
155P63_26484246_Chip-Seq_KERATINOCYTES_Human0.85698731
156RACK7_27058665_Chip-Seq_MCF-7_Human0.85332949
157SOX2_18692474_ChIP-Seq_MEFs_Mouse0.84538619
158TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.81934727

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology6.16492131
2MP0003172_abnormal_lysosome_physiology4.48989349
3MP0009840_abnormal_foam_cell3.85105476
4MP0006082_CNS_inflammation2.95455312
5MP0008438_abnormal_cutaneous_collagen2.72896754
6MP0003191_abnormal_cellular_cholesterol2.69226010
7MP0003195_calcinosis2.67124935
8MP0002139_abnormal_hepatobiliary_system2.59175640
9MP0000604_amyloidosis2.57249465
10MP0005360_urolithiasis2.49275838
11MP0003436_decreased_susceptibility_to2.30533677
12MP0003300_gastrointestinal_ulcer2.23878895
13MP0003183_abnormal_peptide_metabolism2.09282509
14MP0003806_abnormal_nucleotide_metabolis2.06339223
15MP0004019_abnormal_vitamin_homeostasis2.04202554
16MP0005257_abnormal_intraocular_pressure2.03761128
17MP0001835_abnormal_antigen_presentation2.03725320
18MP0005671_abnormal_response_to2.02329848
19MP0002419_abnormal_innate_immunity2.01280283
20MP0005332_abnormal_amino_acid1.95135342
21MP0003705_abnormal_hypodermis_morpholog1.88300856
22MP0001545_abnormal_hematopoietic_system1.87520567
23MP0005397_hematopoietic_system_phenotyp1.87520567
24MP0003763_abnormal_thymus_physiology1.85027559
25MP0003690_abnormal_glial_cell1.84186592
26MP0005083_abnormal_biliary_tract1.79188138
27MP0000569_abnormal_digit_pigmentation1.78646885
28MP0002420_abnormal_adaptive_immunity1.77994161
29MP0003186_abnormal_redox_activity1.75972150
30MP0001958_emphysema1.74134985
31MP0001853_heart_inflammation1.66772528
32MP0002138_abnormal_hepatobiliary_system1.65111160
33MP0003303_peritoneal_inflammation1.63210284
34MP0009643_abnormal_urine_homeostasis1.60612909
35MP0010155_abnormal_intestine_physiology1.57490661
36MP0005365_abnormal_bile_salt1.55461127
37MP0005000_abnormal_immune_tolerance1.53443185
38MP0003252_abnormal_bile_duct1.47559596
39MP0010307_abnormal_tumor_latency1.45326366
40MP0002148_abnormal_hypersensitivity_rea1.44803429
41MP0008469_abnormal_protein_level1.43145504
42MP0009785_altered_susceptibility_to1.41591371
43MP0001533_abnormal_skeleton_physiology1.40298635
44MP0008260_abnormal_autophagy1.40271665
45MP0001756_abnormal_urination1.39693346
46MP0002254_reproductive_system_inflammat1.38437211
47MP0000716_abnormal_immune_system1.37285473
48MP0003453_abnormal_keratinocyte_physiol1.34775348
49MP0002398_abnormal_bone_marrow1.34577214
50MP0005085_abnormal_gallbladder_physiolo1.32747862
51MP0000465_gastrointestinal_hemorrhage1.32017247
52MP0002998_abnormal_bone_remodeling1.31218150
53MP0010386_abnormal_urinary_bladder1.30288565
54MP0004947_skin_inflammation1.29512440
55MP0005025_abnormal_response_to1.29095775
56MP0001873_stomach_inflammation1.28996743
57MP0005464_abnormal_platelet_physiology1.27174547
58MP0005387_immune_system_phenotype1.26435668
59MP0001790_abnormal_immune_system1.26435668
60MP0008875_abnormal_xenobiotic_pharmacok1.26152729
61MP0000371_diluted_coat_color1.20732829
62MP0001849_ear_inflammation1.20519437
63MP0000609_abnormal_liver_physiology1.19526490
64MP0003075_altered_response_to1.19361155
65MP0002933_joint_inflammation1.19172857
66MP0005408_hypopigmentation1.18873757
67MP0000858_altered_metastatic_potential1.17688402
68MP0010329_abnormal_lipoprotein_level1.16957754
69MP0002136_abnormal_kidney_physiology1.16786120
70MP0002429_abnormal_blood_cell1.16495088
71MP0003329_amyloid_beta_deposits1.15980672
72MP0003279_aneurysm1.15976183
73MP0001845_abnormal_inflammatory_respons1.15238917
74MP0002452_abnormal_antigen_presenting1.14872249
75MP0004858_abnormal_nervous_system1.13413469
76MP0001851_eye_inflammation1.12998634
77MP0003448_altered_tumor_morphology1.12874113
78MP0005319_abnormal_enzyme/_coenzyme1.12174502
79MP0003566_abnormal_cell_adhesion1.11103552
80MP0002722_abnormal_immune_system1.10882720
81MP0000689_abnormal_spleen_morphology1.09835710
82MP0009764_decreased_sensitivity_to1.09227639
83MP0001542_abnormal_bone_strength1.08810798
84MP0003724_increased_susceptibility_to1.08478048
85MP0001666_abnormal_nutrient_absorption1.07514453
86MP0005174_abnormal_tail_pigmentation1.06054675
87MP0002295_abnormal_pulmonary_circulatio1.05810232
88MP0004185_abnormal_adipocyte_glucose1.03478234
89MP0005666_abnormal_adipose_tissue1.02685815
90MP0005310_abnormal_salivary_gland1.02439253
91MP0002723_abnormal_immune_serum1.02334003
92MP0002877_abnormal_melanocyte_morpholog1.00978941
93MP0004043_abnormal_pH_regulation0.99872993
94MP0002118_abnormal_lipid_homeostasis0.99534407
95MP0000685_abnormal_immune_system0.98013363
96MP0003091_abnormal_cell_migration0.97702446
97MP0002168_other_aberrant_phenotype0.97279458
98MP0004808_abnormal_hematopoietic_stem0.96327078
99MP0003866_abnormal_defecation0.95915821
100MP0005076_abnormal_cell_differentiation0.95327069
101MP0005165_increased_susceptibility_to0.93406137
102MP0003656_abnormal_erythrocyte_physiolo0.92813084
103MP0003634_abnormal_glial_cell0.92770803
104MP0005023_abnormal_wound_healing0.92483737
105MP0005584_abnormal_enzyme/coenzyme_acti0.88938802
106MP0009278_abnormal_bone_marrow0.88856197
107MP0005164_abnormal_response_to0.87461749
108MP0000920_abnormal_myelination0.87331372
109MP0005670_abnormal_white_adipose0.87164454
110MP0000598_abnormal_liver_morphology0.87119431
111MP0002405_respiratory_system_inflammati0.86759091
112MP0000681_abnormal_thyroid_gland0.86425605
113MP0008874_decreased_physiological_sensi0.86294847
114MP0003828_pulmonary_edema0.86257779
115MP0005636_abnormal_mineral_homeostasis0.85641735
116MP0005166_decreased_susceptibility_to0.85617467
117MP0000703_abnormal_thymus_morphology0.84780524
118MP0001800_abnormal_humoral_immune0.84384775
119MP0002090_abnormal_vision0.83943882
120MP0000343_altered_response_to0.83522760
121MP0004381_abnormal_hair_follicle0.82324898
122MP0000358_abnormal_cell_content/0.81683829
123MP0009333_abnormal_splenocyte_physiolog0.81093171
124MP0008004_abnormal_stomach_pH0.78858141
125MP0009763_increased_sensitivity_to0.78703380
126MP0003795_abnormal_bone_structure0.77713576
127MP0002396_abnormal_hematopoietic_system0.77168089
128MP0005451_abnormal_body_composition0.76981873
129MP0002693_abnormal_pancreas_physiology0.75718233
130MP0005171_absent_coat_pigmentation0.75373799
131MP0001819_abnormal_immune_cell0.75302053
132MP0005375_adipose_tissue_phenotype0.75255573
133MP0000490_abnormal_crypts_of0.73968088
134MP0001764_abnormal_homeostasis0.73765362
135MP0005390_skeleton_phenotype0.73753082
136MP0004510_myositis0.73228460
137MP0000015_abnormal_ear_pigmentation0.73211026
138MP0001663_abnormal_digestive_system0.72906582
139MP0000249_abnormal_blood_vessel0.71677715
140MP0001348_abnormal_lacrimal_gland0.68248344

Predicted human phenotypes

RankGene SetZ-score
1Vacuolated lymphocytes (HP:0001922)6.94910758
2Increased cerebral lipofuscin (HP:0011813)5.89660336
3Dysostosis multiplex (HP:0000943)5.80383795
4Increased neuronal autofluorescent lipopigment (HP:0002074)5.35034682
5Abnormality of glycolipid metabolism (HP:0010969)5.26710714
6Abnormality of liposaccharide metabolism (HP:0010968)5.26710714
7Abnormality of glycosphingolipid metabolism (HP:0004343)5.26710714
8Mucopolysacchariduria (HP:0008155)4.90421260
9Urinary glycosaminoglycan excretion (HP:0003541)4.90421260
10Abnormality of polysaccharide metabolism (HP:0011012)4.75367163
11Abnormality of glycosaminoglycan metabolism (HP:0004371)4.75367163
12Abnormality of mucopolysaccharide metabolism (HP:0011020)4.75367163
13Abnormality of macrophages (HP:0004311)4.25221123
14Axonal loss (HP:0003447)4.09006821
15Systemic lupus erythematosus (HP:0002725)3.99101341
16Recurrent abscess formation (HP:0002722)3.96733705
17Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.88876784
18Recurrent bacterial skin infections (HP:0005406)3.58925871
19Recurrent gram-negative bacterial infections (HP:0005420)3.58579145
20Cervical subluxation (HP:0003308)3.28648835
21Eczematoid dermatitis (HP:0000976)3.11490080
22Vertebral compression fractures (HP:0002953)3.03695394
23Pathologic fracture (HP:0002756)2.88892088
24Global brain atrophy (HP:0002283)2.87659833
25Nuclear cataract (HP:0100018)2.79319217
26Purpura (HP:0000979)2.76115855
27Cellulitis (HP:0100658)2.72796303
28Xanthomatosis (HP:0000991)2.72306130
29Petechiae (HP:0000967)2.68693834
30Chronic obstructive pulmonary disease (HP:0006510)2.68482203
31Obstructive lung disease (HP:0006536)2.68482203
32Mediastinal lymphadenopathy (HP:0100721)2.65022400
33Myocardial infarction (HP:0001658)2.63924645
34Glomerulonephritis (HP:0000099)2.59262053
35Loss of speech (HP:0002371)2.58621825
36Myositis (HP:0100614)2.56848870
37Elevated erythrocyte sedimentation rate (HP:0003565)2.56365671
38Abnormality of the vasculature of the conjunctiva (HP:0008054)2.50355147
39Increased IgE level (HP:0003212)2.49626062
40Colitis (HP:0002583)2.47633986
41Abnormality of glutamine family amino acid metabolism (HP:0010902)2.42665004
42Abnormality of aromatic amino acid family metabolism (HP:0004338)2.40749427
43Upper motor neuron abnormality (HP:0002127)2.40707067
44Retinal atrophy (HP:0001105)2.36475616
45Neuronal loss in central nervous system (HP:0002529)2.36361116
46Beaking of vertebral bodies (HP:0004568)2.34738793
47Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.34306027
48Peripheral demyelination (HP:0011096)2.30042897
49Gingivitis (HP:0000230)2.29798090
50Interstitial pulmonary disease (HP:0006530)2.28316016
51Autoimmune thrombocytopenia (HP:0001973)2.25448838
52Recurrent fungal infections (HP:0002841)2.23769128
53Abnormality of purine metabolism (HP:0004352)2.23486142
54Gastrointestinal inflammation (HP:0004386)2.22742223
55Gastrointestinal stroma tumor (HP:0100723)2.22669811
56Cerebral inclusion bodies (HP:0100314)2.22595495
57Distal lower limb muscle weakness (HP:0009053)2.21817893
58Progressive neurologic deterioration (HP:0002344)2.20261730
59Complement deficiency (HP:0004431)2.19371388
60Agnosia (HP:0010524)2.18935304
61Abnormality of proline metabolism (HP:0010907)2.16464197
62Hydroxyprolinuria (HP:0003080)2.16464197
63Hypertensive crisis (HP:0100735)2.15960388
64Abnormality of complement system (HP:0005339)2.14526892
65Personality changes (HP:0000751)2.13119254
66Achilles tendon contracture (HP:0001771)2.12962828
67Abnormality of the nasal mucosa (HP:0000433)2.11341465
68Thoracic kyphosis (HP:0002942)2.11253340
69Premature rupture of membranes (HP:0001788)2.11162347
70Meningitis (HP:0001287)2.10376635
71Recurrent viral infections (HP:0004429)2.09789703
72Amyloidosis (HP:0011034)2.09203303
73Orchitis (HP:0100796)2.08541008
74Neurofibrillary tangles (HP:0002185)2.05917337
75Joint hemorrhage (HP:0005261)2.05337920
76Turricephaly (HP:0000262)2.04825534
77Sensorimotor neuropathy (HP:0007141)2.04581071
78Prolonged neonatal jaundice (HP:0006579)2.03974134
79Inflammation of the large intestine (HP:0002037)2.03200486
80Centrally nucleated skeletal muscle fibers (HP:0003687)2.02321852
81Gout (HP:0001997)2.02309093
82Recurrent skin infections (HP:0001581)1.99622869
83Ovoid vertebral bodies (HP:0003300)1.98685824
84Conjunctival telangiectasia (HP:0000524)1.98122745
85Broad face (HP:0000283)1.97371029
86Disinhibition (HP:0000734)1.97222701
87Epistaxis (HP:0000421)1.97150053
88Abnormal enzyme/coenzyme activity (HP:0012379)1.96764612
89Hepatosplenomegaly (HP:0001433)1.96651018
90Abnormality of sulfur amino acid metabolism (HP:0004339)1.96375874
91Ketoacidosis (HP:0001993)1.96177329
92Spontaneous hematomas (HP:0007420)1.95784089
93Hand muscle atrophy (HP:0009130)1.95775131
94Obstructive sleep apnea (HP:0002870)1.95419142
95Increased CSF protein (HP:0002922)1.95360283
96Abnormality of alkaline phosphatase activity (HP:0004379)1.93762554
97Osteolytic defects of the hand bones (HP:0009699)1.93639368
98Osteolytic defects of the phalanges of the hand (HP:0009771)1.93639368
99Abnormality of monocarboxylic acid metabolism (HP:0010996)1.93009597
100Joint stiffness (HP:0001387)1.92125405
101Diminished motivation (HP:0000745)1.92006715
102Increased serum ferritin (HP:0003281)1.91444125
103Spinal muscular atrophy (HP:0007269)1.91237903
104Abnormality of nucleobase metabolism (HP:0010932)1.91223975
105Prolonged bleeding time (HP:0003010)1.91093141
106Emphysema (HP:0002097)1.90145584
107Abnormality of the Achilles tendon (HP:0005109)1.90010583
108Progressive visual loss (HP:0000529)1.89889370
109J-shaped sella turcica (HP:0002680)1.89781250
110Hypokinesia (HP:0002375)1.89765234
111Nausea (HP:0002018)1.88507492
112Thin bony cortex (HP:0002753)1.88490827
113Abnormality of the thoracic spine (HP:0100711)1.88307819
114Intrahepatic cholestasis (HP:0001406)1.88299251
115Poor head control (HP:0002421)1.88003736
116Agammaglobulinemia (HP:0004432)1.87322206
117Bone pain (HP:0002653)1.87066315
118Protuberant abdomen (HP:0001538)1.86761269
119Nephritis (HP:0000123)1.86697891
120Hyperglycinuria (HP:0003108)1.86149882
121Ketosis (HP:0001946)1.85949060
122Hyperacusis (HP:0010780)1.85709987
123Skin nodule (HP:0200036)1.84478733
124Hypertriglyceridemia (HP:0002155)1.84260752
125Restrictive lung disease (HP:0002091)1.83834390
126Neurodegeneration (HP:0002180)1.83701238
127Apathy (HP:0000741)1.83381792
128Cerebral aneurysm (HP:0004944)1.83375466
129Stomatitis (HP:0010280)1.83352739
130Ragged-red muscle fibers (HP:0003200)1.81695766
131Tetraparesis (HP:0002273)1.81512358
132Polygenic inheritance (HP:0010982)1.80374309
133Asymmetric septal hypertrophy (HP:0001670)1.80032507
134Peritonitis (HP:0002586)1.79546424
135Basal ganglia calcification (HP:0002135)1.79009868
136Abnormality of transition element cation homeostasis (HP:0011030)1.78728498
137Elevated alkaline phosphatase (HP:0003155)1.78505401
138Cholecystitis (HP:0001082)1.78381244
139Abnormal gallbladder physiology (HP:0012438)1.78381244
140Hypophosphatemia (HP:0002148)1.77021243
141Hemorrhage of the eye (HP:0011885)1.76885150
142Polycythemia (HP:0001901)1.76852652
143Hypoplasia of the odontoid process (HP:0003311)1.76597000
144Fatigue (HP:0012378)1.76579112
145Vasculitis (HP:0002633)1.76439627
146Mutism (HP:0002300)1.76248890
147Pustule (HP:0200039)1.75821024
148Abnormality of iron homeostasis (HP:0011031)1.75675222
149Distal lower limb amyotrophy (HP:0008944)1.74575685
150Clumsiness (HP:0002312)1.74149907
151Supranuclear gaze palsy (HP:0000605)1.68593479
152Spondylolisthesis (HP:0003302)1.68276113

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.30279151
2IRAK34.13157688
3PRPF4B2.97319662
4MAP3K142.55080119
5SCYL22.53647005
6RIPK42.52167487
7TYK22.48155479
8BCKDK2.46914188
9TBK12.31165634
10NME22.20389964
11BLK2.11838272
12TRIB32.06427901
13KIT2.05347412
14ARAF1.88270106
15PBK1.87873737
16MAP3K131.87476231
17EPHA21.81035534
18SMG11.75345568
19TESK11.74945071
20IRAK41.71933798
21ABL21.68412237
22CAMKK21.61772906
23TAOK31.59989800
24TGFBR21.58701212
25MET1.56179405
26TNK21.55687719
27IKBKB1.55551300
28PIM21.54667786
29JAK11.44272216
30FGR1.43549233
31MST1R1.43360259
32NEK91.40361570
33DDR21.40329479
34MAP3K31.39744680
35TAOK11.37642678
36MOS1.36183102
37ICK1.31375657
38NTRK11.30686264
39PAK41.29490278
40JAK31.26663233
41ZAP701.24347783
42FES1.23506677
43MAP3K21.20418778
44MAP4K11.14958055
45EEF2K1.12114251
46EIF2AK31.11512581
47FLT31.09247798
48PRKD21.07621552
49WNK31.05895258
50MARK31.04637234
51BTK1.03642078
52BMX1.01148570
53CDC42BPA0.99853544
54CSF1R0.99491473
55MARK20.97704011
56JAK20.97013781
57LRRK20.96595031
58TTN0.92339933
59EPHB10.89894450
60SIK20.87953582
61PTK60.87410243
62TRPM70.87190077
63FGFR40.86173771
64CSK0.85820620
65MAPK120.85410512
66PDGFRA0.85242162
67LYN0.83423815
68HCK0.82929350
69MAP2K60.82014547
70HIPK20.79281453
71SIK30.78162492
72PIM10.77034501
73BRAF0.76776602
74MAPKAPK30.75851791
75MATK0.75631969
76AKT30.73465848
77GRK60.73201903
78CAMK1D0.73166298
79BUB10.72704468
80RPS6KA20.72589110
81PTK20.71920172
82PDK20.70726920
83IRAK20.70640423
84EGFR0.70175445
85PRKCD0.70162070
86RPS6KC10.70109989
87RPS6KL10.70109989
88PDK10.67056758
89GSK3A0.66250026
90SYK0.66220966
91MAPK110.63903572
92WNK40.63628799
93MST40.63166278
94IKBKE0.62061811
95ERBB40.60631560
96KDR0.60506425
97MAP3K80.60492300
98PDPK10.59512811
99TESK20.58939315
100RPS6KA40.58794939
101MAP3K60.57419051
102STK100.54266992
103ABL10.54235260
104MAP3K110.53620681
105MAPK40.53402237
106MAPK70.52056147
107PRKD30.51496562
108ITK0.50785247
109RPS6KA60.50725203
110GRK70.50699952
111LCK0.49659485
112GRK50.49386342
113CHUK0.49290704
114PKN20.46873684
115DAPK30.45852432
116INSRR0.45589779
117CDK120.45263731
118YES10.43766324
119CAMKK10.43299949
120MAP2K30.43250020
121RIPK10.43243711
122SIK10.42955833
123KSR20.42888177
124CDK40.42566606
125BMPR20.42476420
126MAP2K20.42038415
127PRKD10.41565665
128PAK10.41480713
129MAP3K70.41334576
130MAPKAPK20.41278672
131PIK3CG0.40622298
132MAPK150.40397284
133DAPK10.40046273
134IRAK10.38331721
135PRKCH0.37176211
136MTOR0.35111641
137MAP3K10.34637987
138TAOK20.32451271

Predicted pathways (KEGG)

RankGene SetZ-score
1Lysosome_Homo sapiens_hsa041424.41984192
2Other glycan degradation_Homo sapiens_hsa005113.96365234
3Glycosaminoglycan degradation_Homo sapiens_hsa005313.84816726
4Staphylococcus aureus infection_Homo sapiens_hsa051502.85116685
5Collecting duct acid secretion_Homo sapiens_hsa049662.65496604
6Pentose and glucuronate interconversions_Homo sapiens_hsa000402.20853282
7Rheumatoid arthritis_Homo sapiens_hsa053232.19097299
8Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.14390376
9Phagosome_Homo sapiens_hsa041452.07648005
10Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.07261515
11Allograft rejection_Homo sapiens_hsa053302.00038809
12Complement and coagulation cascades_Homo sapiens_hsa046101.92732444
13Steroid biosynthesis_Homo sapiens_hsa001001.90494883
14B cell receptor signaling pathway_Homo sapiens_hsa046621.87030354
15Folate biosynthesis_Homo sapiens_hsa007901.86129213
16Acute myeloid leukemia_Homo sapiens_hsa052211.82783513
17Autoimmune thyroid disease_Homo sapiens_hsa053201.79726394
18Primary bile acid biosynthesis_Homo sapiens_hsa001201.71161300
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.60063546
20Primary immunodeficiency_Homo sapiens_hsa053401.59517075
21Tuberculosis_Homo sapiens_hsa051521.56662814
22Asthma_Homo sapiens_hsa053101.55850254
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.53314780
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.49314157
25Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.49004962
26Vibrio cholerae infection_Homo sapiens_hsa051101.48401747
27Toxoplasmosis_Homo sapiens_hsa051451.45924303
28Legionellosis_Homo sapiens_hsa051341.43483805
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.41331983
30Peroxisome_Homo sapiens_hsa041461.37765275
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.34867791
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.32520816
33Vitamin digestion and absorption_Homo sapiens_hsa049771.32261356
34VEGF signaling pathway_Homo sapiens_hsa043701.32056240
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.31640395
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.31075929
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.29760937
38Caffeine metabolism_Homo sapiens_hsa002321.28681699
39Malaria_Homo sapiens_hsa051441.27473561
40Viral myocarditis_Homo sapiens_hsa054161.25218131
41Leishmaniasis_Homo sapiens_hsa051401.23650320
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.21080780
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.21071395
44Sphingolipid metabolism_Homo sapiens_hsa006001.19195527
45Salmonella infection_Homo sapiens_hsa051321.17953219
46Arginine biosynthesis_Homo sapiens_hsa002201.16741809
47Histidine metabolism_Homo sapiens_hsa003401.14843108
48Hematopoietic cell lineage_Homo sapiens_hsa046401.14522554
49Tryptophan metabolism_Homo sapiens_hsa003801.13251814
50Fructose and mannose metabolism_Homo sapiens_hsa000511.09861026
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.09737745
52Nitrogen metabolism_Homo sapiens_hsa009101.09637778
53Toll-like receptor signaling pathway_Homo sapiens_hsa046201.08839384
54Proteasome_Homo sapiens_hsa030501.08767426
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.08169713
56T cell receptor signaling pathway_Homo sapiens_hsa046601.08085868
57Herpes simplex infection_Homo sapiens_hsa051681.06868943
58Drug metabolism - other enzymes_Homo sapiens_hsa009831.06175996
59Renin-angiotensin system_Homo sapiens_hsa046141.05481235
60Osteoclast differentiation_Homo sapiens_hsa043801.04397042
61Pertussis_Homo sapiens_hsa051331.03721773
62Chronic myeloid leukemia_Homo sapiens_hsa052201.03714411
63Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.02574888
64Shigellosis_Homo sapiens_hsa051311.02097351
65Prion diseases_Homo sapiens_hsa050201.01352778
66Hepatitis C_Homo sapiens_hsa051601.00783271
67Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.99155869
68Galactose metabolism_Homo sapiens_hsa000520.98764109
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97997858
70Measles_Homo sapiens_hsa051620.97056547
71Bladder cancer_Homo sapiens_hsa052190.96402402
72Selenocompound metabolism_Homo sapiens_hsa004500.94648696
73Notch signaling pathway_Homo sapiens_hsa043300.94360207
74Arginine and proline metabolism_Homo sapiens_hsa003300.94070808
75Hepatitis B_Homo sapiens_hsa051610.93346481
76Sulfur metabolism_Homo sapiens_hsa009200.92007923
77Non-small cell lung cancer_Homo sapiens_hsa052230.92003284
78Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.91161527
79Butanoate metabolism_Homo sapiens_hsa006500.90814535
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90306243
81Pentose phosphate pathway_Homo sapiens_hsa000300.89536899
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.87819752
83NF-kappa B signaling pathway_Homo sapiens_hsa040640.86373171
84Chemokine signaling pathway_Homo sapiens_hsa040620.85745087
85Sulfur relay system_Homo sapiens_hsa041220.84713132
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.84348417
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.82780537
88Starch and sucrose metabolism_Homo sapiens_hsa005000.82387291
89Fatty acid degradation_Homo sapiens_hsa000710.80881419
90Endocytosis_Homo sapiens_hsa041440.79832291
91Synaptic vesicle cycle_Homo sapiens_hsa047210.79362669
92Pancreatic cancer_Homo sapiens_hsa052120.78021937
93Glutathione metabolism_Homo sapiens_hsa004800.77049571
94Regulation of autophagy_Homo sapiens_hsa041400.76933222
95Platelet activation_Homo sapiens_hsa046110.75076903
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.74730200
97Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74136583
98Mineral absorption_Homo sapiens_hsa049780.73729540
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.73337767
100Apoptosis_Homo sapiens_hsa042100.73203496
101Biosynthesis of amino acids_Homo sapiens_hsa012300.72203720
102Jak-STAT signaling pathway_Homo sapiens_hsa046300.72046685
103NOD-like receptor signaling pathway_Homo sapiens_hsa046210.70192079
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.70083559
105Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.69078896
106Carbon metabolism_Homo sapiens_hsa012000.68915766
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.67605358
108Prolactin signaling pathway_Homo sapiens_hsa049170.67113815
109mTOR signaling pathway_Homo sapiens_hsa041500.66880983
110beta-Alanine metabolism_Homo sapiens_hsa004100.66804103
111HTLV-I infection_Homo sapiens_hsa051660.66331977
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66269856
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65832809
114Protein export_Homo sapiens_hsa030600.65646133
115Vitamin B6 metabolism_Homo sapiens_hsa007500.65531140
116Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64931696
117Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63683047
118Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63544860
119Phenylalanine metabolism_Homo sapiens_hsa003600.63436668
120SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63002443
121GnRH signaling pathway_Homo sapiens_hsa049120.62828767
122African trypanosomiasis_Homo sapiens_hsa051430.62516179
123Epstein-Barr virus infection_Homo sapiens_hsa051690.61870168
124Antigen processing and presentation_Homo sapiens_hsa046120.61524917
125PPAR signaling pathway_Homo sapiens_hsa033200.59980306
126Glycerolipid metabolism_Homo sapiens_hsa005610.57878144
127Fatty acid metabolism_Homo sapiens_hsa012120.56975599
128Central carbon metabolism in cancer_Homo sapiens_hsa052300.54294118
129Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54275708
130ABC transporters_Homo sapiens_hsa020100.54168348
131Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53267960
132Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.52756120
133Insulin resistance_Homo sapiens_hsa049310.49331259
134Cyanoamino acid metabolism_Homo sapiens_hsa004600.48265856
135Fat digestion and absorption_Homo sapiens_hsa049750.47560356
136Cysteine and methionine metabolism_Homo sapiens_hsa002700.47125781
137Chemical carcinogenesis_Homo sapiens_hsa052040.46511619
138Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46487886
139Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46260450
140HIF-1 signaling pathway_Homo sapiens_hsa040660.46139990
141Bile secretion_Homo sapiens_hsa049760.45915467
142RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45825318
143Viral carcinogenesis_Homo sapiens_hsa052030.45287574
144Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45165953
145Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44993973
146Glycerophospholipid metabolism_Homo sapiens_hsa005640.44552223
147Graft-versus-host disease_Homo sapiens_hsa053320.44062037
148Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43616833
149Insulin signaling pathway_Homo sapiens_hsa049100.43543882
150TNF signaling pathway_Homo sapiens_hsa046680.42323645
151Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41950276
152Type I diabetes mellitus_Homo sapiens_hsa049400.41765199
153Renal cell carcinoma_Homo sapiens_hsa052110.41665988
154Metabolic pathways_Homo sapiens_hsa011000.41558846
155Fatty acid elongation_Homo sapiens_hsa000620.41041694
156One carbon pool by folate_Homo sapiens_hsa006700.40624980
157Influenza A_Homo sapiens_hsa051640.40017466
158Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39804565
159Amoebiasis_Homo sapiens_hsa051460.39330299
160Arachidonic acid metabolism_Homo sapiens_hsa005900.38905244
161Estrogen signaling pathway_Homo sapiens_hsa049150.37045684

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