DPH3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a CSL zinc finger-containing protein that is required for dipthamide biosynthesis. The encoded protein is necessary for the initial step in the modification of a histidine residue in elongation factor-2 to diphthamide. This modified residue is a target for ADP ribosylation by the bacterial toxins diphtheria toxin and Pseudomonas exotoxin A. Alternative splicing results in multiple transcript variants that encode the same isoform. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.06544229
2ribosomal small subunit biogenesis (GO:0042274)5.72654350
3viral transcription (GO:0019083)5.68992684
4DNA deamination (GO:0045006)5.57717387
5translational termination (GO:0006415)5.57577974
6maturation of SSU-rRNA (GO:0030490)5.56843032
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.31666595
8cotranslational protein targeting to membrane (GO:0006613)5.25339205
9protein targeting to ER (GO:0045047)5.21148879
10proteasome assembly (GO:0043248)5.14083837
11ribosomal large subunit biogenesis (GO:0042273)5.10260323
12protein localization to endoplasmic reticulum (GO:0070972)4.95886910
13establishment of protein localization to endoplasmic reticulum (GO:0072599)4.95124442
14translational elongation (GO:0006414)4.91527619
15termination of RNA polymerase III transcription (GO:0006386)4.70492207
16transcription elongation from RNA polymerase III promoter (GO:0006385)4.70492207
17mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.70191102
18translational initiation (GO:0006413)4.55105054
19cellular protein complex disassembly (GO:0043624)4.45427584
20energy coupled proton transport, down electrochemical gradient (GO:0015985)4.42901474
21ATP synthesis coupled proton transport (GO:0015986)4.42901474
22viral life cycle (GO:0019058)4.39532315
23DNA double-strand break processing (GO:0000729)4.38791190
24translation (GO:0006412)4.34611473
25nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.26687046
26ribonucleoprotein complex biogenesis (GO:0022613)4.26116245
27regulation of mitochondrial translation (GO:0070129)4.18078132
287-methylguanosine mRNA capping (GO:0006370)4.09843464
29negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.07761487
30mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.07218862
31RNA capping (GO:0036260)4.03047608
327-methylguanosine RNA capping (GO:0009452)4.03047608
33chaperone-mediated protein transport (GO:0072321)4.00152250
34L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.98348848
35cellular component biogenesis (GO:0044085)3.93001074
36positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.88021260
37protein complex biogenesis (GO:0070271)3.87727922
38regulation of cellular amino acid metabolic process (GO:0006521)3.82050212
39protein complex disassembly (GO:0043241)3.80944808
40regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.79232218
41negative regulation of ligase activity (GO:0051352)3.77149178
42negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.77149178
43regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.73316765
44regulation of mitotic spindle checkpoint (GO:1903504)3.73316765
45rRNA processing (GO:0006364)3.73179619
46anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.72941860
47GTP biosynthetic process (GO:0006183)3.71956803
48deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.71660541
49rRNA modification (GO:0000154)3.71543470
50mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.68553625
51mitochondrial respiratory chain complex I assembly (GO:0032981)3.68553625
52NADH dehydrogenase complex assembly (GO:0010257)3.68553625
53macromolecular complex disassembly (GO:0032984)3.67291332
54CENP-A containing nucleosome assembly (GO:0034080)3.66536497
55mitochondrial respiratory chain complex assembly (GO:0033108)3.65495656
56purine nucleobase biosynthetic process (GO:0009113)3.64719728
57protein neddylation (GO:0045116)3.61906900
58formation of translation preinitiation complex (GO:0001731)3.61369576
59rRNA metabolic process (GO:0016072)3.60011361
60guanosine-containing compound biosynthetic process (GO:1901070)3.59454906
61exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.57888723
62respiratory electron transport chain (GO:0022904)3.57627990
63spliceosomal snRNP assembly (GO:0000387)3.57555440
64protein localization to mitochondrion (GO:0070585)3.55774906
65pseudouridine synthesis (GO:0001522)3.54238279
66chromatin remodeling at centromere (GO:0031055)3.54197743
67DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.53320292
68nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.52650354
69telomere maintenance via semi-conservative replication (GO:0032201)3.51401901
70antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.49653286
71electron transport chain (GO:0022900)3.48706104
72signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.46578992
73signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.46578992
74signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.46578992
75signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.45660028
76intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.45660028
77protein deneddylation (GO:0000338)3.44578340
78positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.43455367
79histone exchange (GO:0043486)3.42578735
80ribosome biogenesis (GO:0042254)3.42118547
81protein targeting to mitochondrion (GO:0006626)3.41723802
82transcription-coupled nucleotide-excision repair (GO:0006283)3.41660427
83protein targeting to membrane (GO:0006612)3.41480034
84establishment of protein localization to mitochondrial membrane (GO:0090151)3.40666268
85ribosome assembly (GO:0042255)3.38698478
86cytochrome complex assembly (GO:0017004)3.37903967
87signal transduction involved in DNA integrity checkpoint (GO:0072401)3.37858243
88signal transduction involved in DNA damage checkpoint (GO:0072422)3.37858243
89spliceosomal complex assembly (GO:0000245)3.37250852
90establishment of integrated proviral latency (GO:0075713)3.35318952
91nucleobase biosynthetic process (GO:0046112)3.35018154
92regulation of ubiquitin-protein transferase activity (GO:0051438)3.34810044
93UTP biosynthetic process (GO:0006228)3.34664718
94signal transduction involved in cell cycle checkpoint (GO:0072395)3.34468652
95positive regulation of ligase activity (GO:0051351)3.33020012
96DNA replication checkpoint (GO:0000076)3.31984580
97establishment of protein localization to mitochondrion (GO:0072655)3.31633241
98nuclear-transcribed mRNA catabolic process (GO:0000956)3.31600595
99transcription from RNA polymerase I promoter (GO:0006360)3.30989592
100respiratory chain complex IV assembly (GO:0008535)3.29990275
101DNA strand elongation involved in DNA replication (GO:0006271)3.29465483
102termination of RNA polymerase I transcription (GO:0006363)3.29372788
103regulation of ligase activity (GO:0051340)3.25819394
104organelle disassembly (GO:1903008)3.25682177
105antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.25180060
106rRNA methylation (GO:0031167)3.22302193
107mitotic metaphase plate congression (GO:0007080)3.21679161
108cullin deneddylation (GO:0010388)3.21554393
109L-methionine biosynthetic process (GO:0071265)3.21187288
110amino acid salvage (GO:0043102)3.21187288
111L-methionine salvage (GO:0071267)3.21187288
112DNA damage response, detection of DNA damage (GO:0042769)3.20503823
113histone mRNA metabolic process (GO:0008334)3.18913856
114transcription elongation from RNA polymerase I promoter (GO:0006362)3.18747895
115protein-cofactor linkage (GO:0018065)3.18020938
116RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.14271589
117tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.14271589
118protein K11-linked ubiquitination (GO:0070979)3.13971202
119platelet dense granule organization (GO:0060155)3.02392478
120DNA catabolic process, exonucleolytic (GO:0000738)3.01632739
121hydrogen ion transmembrane transport (GO:1902600)2.97681899
122negative regulation of protein ubiquitination (GO:0031397)2.93305142
123intracellular protein transmembrane import (GO:0044743)2.91823350
124metaphase plate congression (GO:0051310)2.90437025
125maturation of 5.8S rRNA (GO:0000460)2.90277139
126replication fork processing (GO:0031297)2.87513624
127regulation of cellular amine metabolic process (GO:0033238)2.83031915
128DNA replication-independent nucleosome assembly (GO:0006336)2.82467700
129DNA replication-independent nucleosome organization (GO:0034724)2.82467700
130resolution of meiotic recombination intermediates (GO:0000712)2.80872137
131mitochondrial transport (GO:0006839)2.80390965
132mannosylation (GO:0097502)2.79896593
133ATP biosynthetic process (GO:0006754)2.79585059
134water-soluble vitamin biosynthetic process (GO:0042364)2.77448432
135ribonucleoprotein complex disassembly (GO:0032988)2.75960260
136negative regulation of DNA-dependent DNA replication (GO:2000104)2.75670088
137dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.75591333
138anterograde synaptic vesicle transport (GO:0048490)2.74634083
139positive regulation of cell cycle arrest (GO:0071158)2.74377555
140negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.74273539
141proton transport (GO:0015992)2.74203976
142inner mitochondrial membrane organization (GO:0007007)2.73746763
143spindle checkpoint (GO:0031577)2.73126601
144response to redox state (GO:0051775)2.71914152
145purine nucleoside triphosphate biosynthetic process (GO:0009145)2.70752738
146establishment of viral latency (GO:0019043)2.70433654

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.79419719
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.51189529
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.37632790
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.09999968
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.01012398
6E2F7_22180533_ChIP-Seq_HELA_Human3.93394109
7* ETS1_20019798_ChIP-Seq_JURKAT_Human3.77119553
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.61811441
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.61698473
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.37249400
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.28375404
12MYC_18358816_ChIP-ChIP_MESCs_Mouse3.16665380
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.04193396
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.00295638
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.94057155
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.88725872
17* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.88062353
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.87437230
19* VDR_23849224_ChIP-Seq_CD4+_Human2.78790377
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.78591565
21XRN2_22483619_ChIP-Seq_HELA_Human2.59986673
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.58473285
23DCP1A_22483619_ChIP-Seq_HELA_Human2.56928423
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.48087766
25E2F4_17652178_ChIP-ChIP_JURKAT_Human2.43146619
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.36933825
27THAP11_20581084_ChIP-Seq_MESCs_Mouse2.25355032
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.22402916
29FOXP3_21729870_ChIP-Seq_TREG_Human2.18394376
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.17087839
31TTF2_22483619_ChIP-Seq_HELA_Human2.15093708
32* SRF_21415370_ChIP-Seq_HL-1_Mouse2.14000270
33* GABP_19822575_ChIP-Seq_HepG2_Human2.12103083
34ELK1_19687146_ChIP-ChIP_HELA_Human2.11852357
35ZNF274_21170338_ChIP-Seq_K562_Hela2.03862147
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.03463091
37YY1_21170310_ChIP-Seq_MESCs_Mouse2.02148845
38* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.99784688
39EWS_26573619_Chip-Seq_HEK293_Human1.96171281
40VDR_22108803_ChIP-Seq_LS180_Human1.88331267
41* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87957074
42FUS_26573619_Chip-Seq_HEK293_Human1.83925799
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.83380755
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.81010525
45* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.79784719
46FLI1_27457419_Chip-Seq_LIVER_Mouse1.77050861
47SALL1_21062744_ChIP-ChIP_HESCs_Human1.76472471
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.75400428
49MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.73521145
50FOXM1_23109430_ChIP-Seq_U2OS_Human1.71748423
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.65953597
52* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.65601657
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.65580091
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.65295508
55ELK1_22589737_ChIP-Seq_MCF10A_Human1.59511030
56P300_19829295_ChIP-Seq_ESCs_Human1.59497380
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57719154
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.56355786
59TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.51702212
60IGF1R_20145208_ChIP-Seq_DFB_Human1.50964161
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.48273464
62* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47832771
63ZFP57_27257070_Chip-Seq_ESCs_Mouse1.46053992
64* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45013918
65NANOG_18555785_ChIP-Seq_MESCs_Mouse1.37553410
66FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.34625080
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34269292
68PCGF2_27294783_Chip-Seq_ESCs_Mouse1.34262248
69BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.32358355
70POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29338558
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28938089
72TAF15_26573619_Chip-Seq_HEK293_Human1.27908597
73TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23598267
74NANOG_16153702_ChIP-ChIP_HESCs_Human1.23491907
75POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22879205
76* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.21704340
77MYC_18940864_ChIP-ChIP_HL60_Human1.21636914
78* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.20115038
79AR_21909140_ChIP-Seq_LNCAP_Human1.18492841
80CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18386653
81E2F1_21310950_ChIP-Seq_MCF-7_Human1.18226994
82KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.17433842
83KDM5A_27292631_Chip-Seq_BREAST_Human1.16963688
84CIITA_25753668_ChIP-Seq_RAJI_Human1.15991485
85EZH2_27294783_Chip-Seq_NPCs_Mouse1.14857687
86MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13485365
87KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.12471307
88CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.10799619
89RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.10329519
90NOTCH1_21737748_ChIP-Seq_TLL_Human1.09507305
91RBPJ_22232070_ChIP-Seq_NCS_Mouse1.08635471
92CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05700749
93CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05375831
94SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05037342
95DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.04250154
96EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03059678
97CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01069386
98SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00118999
99NANOG_19829295_ChIP-Seq_ESCs_Human0.99981857
100SOX2_19829295_ChIP-Seq_ESCs_Human0.99981857
101TP53_22573176_ChIP-Seq_HFKS_Human0.99049303
102E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98669552
103GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97660902
104SOX2_16153702_ChIP-ChIP_HESCs_Human0.97594622
105NFE2_27457419_Chip-Seq_LIVER_Mouse0.97545620
106SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.97527679
107SOX17_20123909_ChIP-Seq_XEN_Mouse0.96604460
108CTCF_18555785_ChIP-Seq_MESCs_Mouse0.95623400
109HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.95114500
110UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92584756
111CRX_20693478_ChIP-Seq_RETINA_Mouse0.92007842
112CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91810489
113IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91627175
114CBP_20019798_ChIP-Seq_JUKART_Human0.91627175
115ER_23166858_ChIP-Seq_MCF-7_Human0.91433248
116KLF4_18555785_ChIP-Seq_MESCs_Mouse0.88854562
117GBX2_23144817_ChIP-Seq_PC3_Human0.88331797
118SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.87812726
119GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87811416
120GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.87760573
121TFEB_21752829_ChIP-Seq_HELA_Human0.87492856
122KLF5_20875108_ChIP-Seq_MESCs_Mouse0.85644718
123SALL4_22934838_ChIP-ChIP_CD34+_Human0.84965863
124OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83222620
125FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.82618583
126STAT3_1855785_ChIP-Seq_MESCs_Mouse0.82257696
127* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80129889
128SOX2_18555785_ChIP-Seq_MESCs_Mouse0.80046859
129SPI1_23547873_ChIP-Seq_NB4_Human0.78543245
130* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.78453071
131IRF1_19129219_ChIP-ChIP_H3396_Human0.78095556
132HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.76166336
133SOX2_18692474_ChIP-Seq_MEFs_Mouse0.75904125
134* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.75772130
135* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.74673932
136TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.71618131
137POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.69700249
138YY1_22570637_ChIP-Seq_MALME-3M_Human0.69429221
139CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.67776288
140OCT4_18692474_ChIP-Seq_MEFs_Mouse0.66777179
141FOXP1_21924763_ChIP-Seq_HESCs_Human0.65533712
142* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.64191123
143ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.63924217

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.95191617
2MP0009379_abnormal_foot_pigmentation4.83829753
3MP0004957_abnormal_blastocyst_morpholog3.79639455
4MP0002102_abnormal_ear_morphology3.25341809
5MP0003111_abnormal_nucleus_morphology3.12567047
6MP0003077_abnormal_cell_cycle3.04597780
7MP0008058_abnormal_DNA_repair3.01723223
8MP0010094_abnormal_chromosome_stability3.01630117
9MP0008932_abnormal_embryonic_tissue2.73638692
10MP0003186_abnormal_redox_activity2.60600008
11MP0003136_yellow_coat_color2.54061393
12MP0006036_abnormal_mitochondrial_physio2.49642576
13MP0003718_maternal_effect2.48902275
14MP0002837_dystrophic_cardiac_calcinosis2.34380717
15MP0008057_abnormal_DNA_replication2.26955457
16MP0003786_premature_aging2.17462221
17MP0008007_abnormal_cellular_replicative2.13259063
18MP0008789_abnormal_olfactory_epithelium2.07648411
19MP0002163_abnormal_gland_morphology2.06898647
20MP0009697_abnormal_copulation1.99828187
21MP0000372_irregular_coat_pigmentation1.91226031
22MP0004147_increased_porphyrin_level1.90548765
23MP0003195_calcinosis1.88913986
24MP0003123_paternal_imprinting1.86869760
25MP0003806_abnormal_nucleotide_metabolis1.84671738
26MP0001293_anophthalmia1.81209617
27MP0003880_abnormal_central_pattern1.79387867
28MP0008260_abnormal_autophagy1.72416934
29MP0002132_abnormal_respiratory_system1.70063583
30MP0002736_abnormal_nociception_after1.65570811
31MP0003941_abnormal_skin_development1.63171639
32MP0005253_abnormal_eye_physiology1.57538371
33MP0001986_abnormal_taste_sensitivity1.56808222
34MP0001529_abnormal_vocalization1.56295595
35MP0008877_abnormal_DNA_methylation1.55005973
36MP0005379_endocrine/exocrine_gland_phen1.51421403
37MP0003950_abnormal_plasma_membrane1.50705368
38MP0006292_abnormal_olfactory_placode1.50000353
39MP0002638_abnormal_pupillary_reflex1.49836898
40MP0001984_abnormal_olfaction1.45473721
41MP0001730_embryonic_growth_arrest1.42021407
42MP0000750_abnormal_muscle_regeneration1.38779073
43MP0000566_synostosis1.38145152
44MP0002090_abnormal_vision1.37187557
45MP0006035_abnormal_mitochondrial_morpho1.33367614
46MP0004142_abnormal_muscle_tone1.32862603
47MP0001905_abnormal_dopamine_level1.32334165
48MP0005499_abnormal_olfactory_system1.31789164
49MP0005394_taste/olfaction_phenotype1.31789164
50MP0003646_muscle_fatigue1.26866177
51MP0009333_abnormal_splenocyte_physiolog1.26724985
52MP0002210_abnormal_sex_determination1.26329895
53MP0006072_abnormal_retinal_apoptosis1.25741461
54MP0000313_abnormal_cell_death1.25596387
55MP0002254_reproductive_system_inflammat1.24789630
56MP0006276_abnormal_autonomic_nervous1.23870936
57MP0002160_abnormal_reproductive_system1.20157615
58MP0002938_white_spotting1.19932362
59MP0002277_abnormal_respiratory_mucosa1.19781822
60MP0000350_abnormal_cell_proliferation1.19581422
61MP0003011_delayed_dark_adaptation1.18999846
62MP0002233_abnormal_nose_morphology1.17575097
63MP0000516_abnormal_urinary_system1.16320440
64MP0005367_renal/urinary_system_phenotyp1.16320440
65MP0005389_reproductive_system_phenotype1.15198785
66MP0001929_abnormal_gametogenesis1.14674629
67MP0004043_abnormal_pH_regulation1.14008824
68MP0001764_abnormal_homeostasis1.12684434
69MP0003937_abnormal_limbs/digits/tail_de1.12510987
70MP0000678_abnormal_parathyroid_gland1.12157263
71MP0000490_abnormal_crypts_of1.11975735
72MP0005408_hypopigmentation1.06252455
73MP0005409_darkened_coat_color1.05548261
74MP0001145_abnormal_male_reproductive1.04392687
75MP0005171_absent_coat_pigmentation1.03695134
76MP0002282_abnormal_trachea_morphology0.99987049
77MP0005332_abnormal_amino_acid0.99497505
78MP0003656_abnormal_erythrocyte_physiolo0.99400357
79MP0005085_abnormal_gallbladder_physiolo0.99314765
80MP0003121_genomic_imprinting0.97847002
81MP0000749_muscle_degeneration0.97762709
82MP0009046_muscle_twitch0.97206318
83MP0000653_abnormal_sex_gland0.97107011
84MP0003315_abnormal_perineum_morphology0.96943748
85MP0005084_abnormal_gallbladder_morpholo0.96359015
86MP0005551_abnormal_eye_electrophysiolog0.95417299
87MP0001286_abnormal_eye_development0.93601695
88MP0000358_abnormal_cell_content/0.93205190
89MP0004133_heterotaxia0.91930453
90* MP0001697_abnormal_embryo_size0.91751547
91MP0000647_abnormal_sebaceous_gland0.91465349
92MP0003137_abnormal_impulse_conducting0.90258195
93MP0005391_vision/eye_phenotype0.89352498
94MP0008004_abnormal_stomach_pH0.88919374
95MP0003221_abnormal_cardiomyocyte_apopto0.88459549
96MP0006054_spinal_hemorrhage0.88337087
97MP0005451_abnormal_body_composition0.88190040
98MP0001485_abnormal_pinna_reflex0.87658471
99* MP0002080_prenatal_lethality0.87239331
100MP0001919_abnormal_reproductive_system0.85144282
101MP0002396_abnormal_hematopoietic_system0.84767542
102MP0008995_early_reproductive_senescence0.84462437
103MP0002095_abnormal_skin_pigmentation0.84143960
104MP0001188_hyperpigmentation0.83995732
105MP0003567_abnormal_fetal_cardiomyocyte0.82199452
106MP0001324_abnormal_eye_pigmentation0.81819497
107MP0003755_abnormal_palate_morphology0.81783993
108MP0001542_abnormal_bone_strength0.80967763
109MP0001727_abnormal_embryo_implantation0.80322018
110MP0010030_abnormal_orbit_morphology0.79151449
111MP0002751_abnormal_autonomic_nervous0.78714024
112MP0005636_abnormal_mineral_homeostasis0.78463909
113MP0008872_abnormal_physiological_respon0.77543805
114MP0003119_abnormal_digestive_system0.77398198
115MP0004381_abnormal_hair_follicle0.76516642
116MP0000049_abnormal_middle_ear0.75661998
117MP0005410_abnormal_fertilization0.75440552
118MP0002019_abnormal_tumor_incidence0.72651272
119MP0004145_abnormal_muscle_electrophysio0.70847111
120MP0004084_abnormal_cardiac_muscle0.70508393
121MP0000613_abnormal_salivary_gland0.70043908
122MP0002148_abnormal_hypersensitivity_rea0.69876921
123MP0002295_abnormal_pulmonary_circulatio0.69654289
124MP0000858_altered_metastatic_potential0.69480552
125MP0002693_abnormal_pancreas_physiology0.68983494
126* MP0002084_abnormal_developmental_patter0.68593945
127MP0000631_abnormal_neuroendocrine_gland0.67766693
128MP0005195_abnormal_posterior_eye0.67350493
129MP0005266_abnormal_metabolism0.67176464
130MP0005187_abnormal_penis_morphology0.66933050
131MP0001119_abnormal_female_reproductive0.66923664
132* MP0005380_embryogenesis_phenotype0.66236166
133* MP0001672_abnormal_embryogenesis/_devel0.66236166
134MP0003698_abnormal_male_reproductive0.65497691
135MP0002177_abnormal_outer_ear0.61928429
136MP0010386_abnormal_urinary_bladder0.61607242
137* MP0002085_abnormal_embryonic_tissue0.59990086
138MP0005075_abnormal_melanosome_morpholog0.59442444
139MP0000681_abnormal_thyroid_gland0.59303043
140MP0004782_abnormal_surfactant_physiolog0.58658881
141MP0005330_cardiomyopathy0.57953371
142MP0001853_heart_inflammation0.57658823
143MP0003890_abnormal_embryonic-extraembry0.57037224
144MP0004215_abnormal_myocardial_fiber0.53435440

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.66817187
2Acute necrotizing encephalopathy (HP:0006965)5.19452398
3Abnormal number of erythroid precursors (HP:0012131)5.11937154
4Mitochondrial inheritance (HP:0001427)4.97027535
5Hepatocellular necrosis (HP:0001404)4.80060296
6Abnormal mitochondria in muscle tissue (HP:0008316)4.74645633
7Reticulocytopenia (HP:0001896)4.58768904
8Decreased activity of mitochondrial respiratory chain (HP:0008972)4.51641580
9Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.51641580
10Hepatic necrosis (HP:0002605)4.41222703
11Increased CSF lactate (HP:0002490)4.41006218
12Progressive macrocephaly (HP:0004481)4.18841093
13Acute encephalopathy (HP:0006846)4.11755455
14Increased hepatocellular lipid droplets (HP:0006565)4.11233299
15Macrocytic anemia (HP:0001972)4.05399095
16Cerebral hypomyelination (HP:0006808)3.76647893
17Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.75265642
18Lipid accumulation in hepatocytes (HP:0006561)3.69157730
19Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.64418101
20Renal Fanconi syndrome (HP:0001994)3.62649471
21Increased serum lactate (HP:0002151)3.62064915
22Birth length less than 3rd percentile (HP:0003561)3.58306713
233-Methylglutaconic aciduria (HP:0003535)3.47912633
24Pallor (HP:0000980)3.38874696
25Breast hypoplasia (HP:0003187)3.33623087
26Increased intramyocellular lipid droplets (HP:0012240)3.22960829
27Exertional dyspnea (HP:0002875)3.22774023
28Exercise intolerance (HP:0003546)3.22609119
29Aplastic anemia (HP:0001915)3.15015987
30Respiratory failure (HP:0002878)3.05766255
31Methylmalonic acidemia (HP:0002912)3.02371950
32Aplasia/hypoplasia of the uterus (HP:0008684)2.98201483
33Aplasia/Hypoplasia of the sacrum (HP:0008517)2.96521982
34Lactic acidosis (HP:0003128)2.92206828
35Rough bone trabeculation (HP:0100670)2.88718624
36Stenosis of the external auditory canal (HP:0000402)2.79219210
37Carpal bone hypoplasia (HP:0001498)2.77984251
38Methylmalonic aciduria (HP:0012120)2.75783187
39Increased muscle lipid content (HP:0009058)2.72268894
40Abnormality of glycolysis (HP:0004366)2.69330255
41Increased serum pyruvate (HP:0003542)2.69330255
42Respiratory difficulties (HP:0002880)2.68671400
43Type I transferrin isoform profile (HP:0003642)2.64630304
44Cerebral edema (HP:0002181)2.62062749
45Degeneration of anterior horn cells (HP:0002398)2.60256315
46Abnormality of the anterior horn cell (HP:0006802)2.60256315
47Microvesicular hepatic steatosis (HP:0001414)2.53030497
48CNS demyelination (HP:0007305)2.49957869
49Progressive muscle weakness (HP:0003323)2.49829957
50Hyperglycinemia (HP:0002154)2.49354613
51Hypoplasia of the uterus (HP:0000013)2.47914893
52Abnormal lung lobation (HP:0002101)2.46501913
53Reduced antithrombin III activity (HP:0001976)2.43668515
54Microretrognathia (HP:0000308)2.43439434
55Medial flaring of the eyebrow (HP:0010747)2.41788347
56Oral leukoplakia (HP:0002745)2.40159103
57Leukodystrophy (HP:0002415)2.39285525
58Optic disc pallor (HP:0000543)2.38976786
59Abnormality of renal resorption (HP:0011038)2.37458274
60Abnormal hemoglobin (HP:0011902)2.36636440
61Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.35724571
62Abnormality of methionine metabolism (HP:0010901)2.32453010
63Abnormality of serum amino acid levels (HP:0003112)2.28910921
64Meckel diverticulum (HP:0002245)2.26376173
65Abnormality of the heme biosynthetic pathway (HP:0010472)2.25402304
66Secondary amenorrhea (HP:0000869)2.24959508
6711 pairs of ribs (HP:0000878)2.21998197
68Delayed gross motor development (HP:0002194)2.17657879
69Lethargy (HP:0001254)2.16494541
70Trismus (HP:0000211)2.16446177
71Sparse eyelashes (HP:0000653)2.15874732
72Abnormality of aspartate family amino acid metabolism (HP:0010899)2.15673915
73Molar tooth sign on MRI (HP:0002419)2.15148845
74Abnormality of midbrain morphology (HP:0002418)2.15148845
75Abnormality of the ileum (HP:0001549)2.15093560
76Emotional lability (HP:0000712)2.14011054
77Abnormal trabecular bone morphology (HP:0100671)2.13845387
78X-linked dominant inheritance (HP:0001423)2.11037567
79Congenital, generalized hypertrichosis (HP:0004540)2.10767950
80CNS hypomyelination (HP:0003429)2.09433708
81Patellar aplasia (HP:0006443)2.07880349
82Aplasia/Hypoplasia of the patella (HP:0006498)2.06199581
83Irregular epiphyses (HP:0010582)2.05596812
84Amniotic constriction ring (HP:0009775)2.05311407
85Abnormality of placental membranes (HP:0011409)2.05311407
86Congenital primary aphakia (HP:0007707)2.04866506
87Nephrogenic diabetes insipidus (HP:0009806)2.03162604
88Pancreatic fibrosis (HP:0100732)2.01863559
89Pancreatic cysts (HP:0001737)2.01360986
90Muscle fiber atrophy (HP:0100295)2.00966052
91Type 2 muscle fiber atrophy (HP:0003554)1.99674037
92Colon cancer (HP:0003003)1.98566396
93Multiple enchondromatosis (HP:0005701)1.98106787
94Hypothermia (HP:0002045)1.97772011
95Abnormality of urine glucose concentration (HP:0011016)1.94308460
96Glycosuria (HP:0003076)1.94308460
97Poor head control (HP:0002421)1.94193626
98Cleft eyelid (HP:0000625)1.93506085
99Gait imbalance (HP:0002141)1.92547147
100Parakeratosis (HP:0001036)1.91631523
101Hypoplasia of the radius (HP:0002984)1.91142921
102Bifid tongue (HP:0010297)1.90530658
103Abnormality of chromosome stability (HP:0003220)1.90039402
104Generalized aminoaciduria (HP:0002909)1.90031410
105Aplasia/Hypoplasia of the fovea (HP:0008060)1.89749778
106Hypoplasia of the fovea (HP:0007750)1.89749778
107Abnormality of the fovea (HP:0000493)1.89404602
108Neoplasm of the adrenal gland (HP:0100631)1.89159838
109Aplasia/Hypoplasia of the uvula (HP:0010293)1.88640633
110Pancytopenia (HP:0001876)1.88485632
111Aplasia/Hypoplasia involving the musculature (HP:0001460)1.87097274
112Horseshoe kidney (HP:0000085)1.85526514
113Genital tract atresia (HP:0001827)1.84267132
114True hermaphroditism (HP:0010459)1.83276963
115Vaginal atresia (HP:0000148)1.83047222
116Abnormality of vitamin B metabolism (HP:0004340)1.81869799
117Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.80356372
118Premature ovarian failure (HP:0008209)1.80168744
119Abnormality of the vitamin B12 metabolism (HP:0004341)1.80012197
120Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.79288730
121Abnormal protein N-linked glycosylation (HP:0012347)1.79288730
122Abnormal protein glycosylation (HP:0012346)1.79288730
123Abnormal glycosylation (HP:0012345)1.79288730
124Patent foramen ovale (HP:0001655)1.79102963
125Glossoptosis (HP:0000162)1.77849503
126Hyperphosphaturia (HP:0003109)1.77442650
127Abnormality of alanine metabolism (HP:0010916)1.75517910
128Hyperalaninemia (HP:0003348)1.75517910
129Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.75517910
130Absent thumb (HP:0009777)1.73962781
131Abnormality of the labia minora (HP:0012880)1.72842143
132Postnatal microcephaly (HP:0005484)1.72200336
133Short tibia (HP:0005736)1.71528400
134Congenital ichthyosiform erythroderma (HP:0007431)1.68401667
135Premature graying of hair (HP:0002216)1.68299349
136Supernumerary spleens (HP:0009799)1.67586973
137Abnormality of the preputium (HP:0100587)1.66267150
138Poor suck (HP:0002033)1.65472080
139Median cleft lip (HP:0000161)1.64747024
140Adrenal hypoplasia (HP:0000835)1.64212571
141Abnormality of aromatic amino acid family metabolism (HP:0004338)1.63046580
142Atrophy/Degeneration involving motor neurons (HP:0007373)1.62485896
143Neuroendocrine neoplasm (HP:0100634)1.61530598

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.48235803
2EIF2AK14.02911367
3STK163.97956709
4NME23.84718568
5TRIM283.49359385
6WEE13.38324288
7SRPK13.18789247
8VRK12.98018029
9MAP4K22.60967205
10EIF2AK32.56057335
11PBK2.48575974
12NME12.30808586
13BRSK22.30158841
14TLK12.25731133
15PLK42.22897129
16VRK22.20663902
17ACVR1B2.02682280
18MST41.98252402
19NUAK11.90915737
20PLK21.83514792
21FRK1.72695257
22ZAK1.67684862
23CDC71.67165525
24PIM21.49709589
25TSSK61.49221185
26BRSK11.47854154
27PDK21.43194049
28BRAF1.41750939
29DYRK31.38148374
30PLK11.35960300
31IRAK31.34525990
32RPS6KA41.27005775
33MAP3K111.25665694
34TESK21.23946523
35PLK31.23660773
36EIF2AK21.20671794
37MKNK11.18595917
38MAP3K41.17183143
39DYRK21.14375796
40AURKA1.12468713
41TESK11.09579615
42LIMK11.09551160
43AURKB1.09106396
44MKNK21.08689840
45TIE11.07360938
46BMPR1B1.05970993
47MUSK1.05838241
48CDK191.04603463
49ARAF1.04355838
50TNIK1.02653133
51NEK21.01956253
52ABL20.95755798
53CCNB10.95175122
54TTK0.92515301
55PASK0.92254845
56STK30.87641561
57CSNK1G10.87484943
58BCR0.85962575
59MAP2K20.85556376
60BCKDK0.83255801
61CDK80.83044222
62MAP2K70.82551502
63CSNK1G20.82550216
64IRAK40.81580416
65RPS6KA50.81247107
66SIK30.80297980
67ADRBK20.79384599
68STK240.78210021
69CASK0.77893544
70KDR0.77180860
71TEC0.76902235
72CHEK20.76817013
73ILK0.75701327
74EPHA20.75576762
75CDK70.75548175
76STK38L0.74817854
77NEK90.73967899
78PNCK0.72458980
79GRK10.72138663
80MINK10.71693961
81LATS10.70479284
82OBSCN0.70389016
83MARK30.68289424
84ERBB40.67780461
85CSNK2A10.67376008
86MAPKAPK50.67299908
87PAK30.67227275
88STK390.67005549
89RPS6KB20.66398738
90MYLK0.65058655
91KSR10.64155661
92PRKCE0.63572885
93CSNK2A20.61961305
94CSNK1A1L0.61810658
95PAK10.60901443
96NEK60.58184079
97MAP3K30.55391627
98TAF10.55183214
99ATR0.54269703
100MAP3K120.48785429
101WNK40.48363337
102PRKCG0.47869539
103CLK10.47836631
104INSRR0.45548538
105PKN10.43728688
106MAP3K50.42239834
107AKT30.41802309
108PIK3CG0.41580777
109STK40.40942183
110MAPK130.40559679
111IKBKB0.40454980
112PRKG20.39994869
113CHEK10.39364806
114MAP3K80.38413793
115PINK10.38167053
116EPHB20.37535520
117GRK70.37119586
118MAPK150.36857550
119PRKCI0.34718182
120OXSR10.33451703
121ADRBK10.32559945
122MELK0.32549192
123CAMKK20.32079420
124PAK40.31544058
125FGFR10.31429010
126FER0.30497447
127CDK30.30457760
128CAMK2A0.28246242
129NEK10.27811772
130PIM10.27418658
131ERBB30.27384787
132WNK30.26014815
133ATM0.25334683
134TGFBR10.24287414
135CDK20.24076342
136CAMK2G0.23306344
137PDK30.21109503
138PDK40.21109503
139CSNK1G30.20858039
140NLK0.20607803

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.26901179
2Proteasome_Homo sapiens_hsa030504.48367369
3RNA polymerase_Homo sapiens_hsa030204.26854984
4Protein export_Homo sapiens_hsa030603.47155906
5Oxidative phosphorylation_Homo sapiens_hsa001903.32345745
6DNA replication_Homo sapiens_hsa030303.31726120
7Parkinsons disease_Homo sapiens_hsa050123.05574381
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.00840958
9Mismatch repair_Homo sapiens_hsa034302.89331408
10Pyrimidine metabolism_Homo sapiens_hsa002402.71862499
11Spliceosome_Homo sapiens_hsa030402.66934956
12Homologous recombination_Homo sapiens_hsa034402.48002810
13Huntingtons disease_Homo sapiens_hsa050162.38214742
14Nucleotide excision repair_Homo sapiens_hsa034202.25670752
15RNA transport_Homo sapiens_hsa030132.15451764
16Alzheimers disease_Homo sapiens_hsa050101.96272643
17Propanoate metabolism_Homo sapiens_hsa006401.89591152
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.87664579
19Base excision repair_Homo sapiens_hsa034101.86303899
20Basal transcription factors_Homo sapiens_hsa030221.85763670
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.73614196
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.71491408
23Fanconi anemia pathway_Homo sapiens_hsa034601.65604126
24Purine metabolism_Homo sapiens_hsa002301.60557604
25RNA degradation_Homo sapiens_hsa030181.57906950
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.50838359
27Cell cycle_Homo sapiens_hsa041101.45418134
28Folate biosynthesis_Homo sapiens_hsa007901.39431550
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.34122741
30Non-homologous end-joining_Homo sapiens_hsa034501.26987872
31Pyruvate metabolism_Homo sapiens_hsa006201.22189647
32Vitamin B6 metabolism_Homo sapiens_hsa007501.21360565
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.20172619
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.18029025
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.14191897
36Sulfur relay system_Homo sapiens_hsa041221.07701134
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06718992
38Cardiac muscle contraction_Homo sapiens_hsa042601.06405734
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.01913082
40One carbon pool by folate_Homo sapiens_hsa006701.01040726
41Glutathione metabolism_Homo sapiens_hsa004800.99975645
42Epstein-Barr virus infection_Homo sapiens_hsa051690.94667804
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92627006
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.91332798
45p53 signaling pathway_Homo sapiens_hsa041150.88695367
46Butanoate metabolism_Homo sapiens_hsa006500.84092714
47Arachidonic acid metabolism_Homo sapiens_hsa005900.83497649
48Maturity onset diabetes of the young_Homo sapiens_hsa049500.82289416
49Systemic lupus erythematosus_Homo sapiens_hsa053220.80001531
50SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79709473
51Peroxisome_Homo sapiens_hsa041460.79015010
52Regulation of autophagy_Homo sapiens_hsa041400.78706161
53mRNA surveillance pathway_Homo sapiens_hsa030150.72918925
54Sulfur metabolism_Homo sapiens_hsa009200.72550168
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.69112537
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68957039
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.68171164
58Metabolic pathways_Homo sapiens_hsa011000.67788938
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65422591
60Chemical carcinogenesis_Homo sapiens_hsa052040.64845195
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64739203
62Caffeine metabolism_Homo sapiens_hsa002320.64623313
63Fatty acid metabolism_Homo sapiens_hsa012120.63883441
64Fatty acid degradation_Homo sapiens_hsa000710.62863350
65Pentose phosphate pathway_Homo sapiens_hsa000300.62529577
66Linoleic acid metabolism_Homo sapiens_hsa005910.61452159
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58857809
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57742870
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.57623223
70Phototransduction_Homo sapiens_hsa047440.52787628
71beta-Alanine metabolism_Homo sapiens_hsa004100.51906203
72Tryptophan metabolism_Homo sapiens_hsa003800.51852314
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51676232
74Vibrio cholerae infection_Homo sapiens_hsa051100.50341563
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47518985
76Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.47148165
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46835911
78Retinol metabolism_Homo sapiens_hsa008300.46133253
79Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44995355
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44474637
81TGF-beta signaling pathway_Homo sapiens_hsa043500.42791128
82Herpes simplex infection_Homo sapiens_hsa051680.42331036
83Sphingolipid metabolism_Homo sapiens_hsa006000.40945605
84Ether lipid metabolism_Homo sapiens_hsa005650.40757319
85Legionellosis_Homo sapiens_hsa051340.38045466
86Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37751984
87Fat digestion and absorption_Homo sapiens_hsa049750.36176786
88Oocyte meiosis_Homo sapiens_hsa041140.35834239
89Fatty acid elongation_Homo sapiens_hsa000620.35104556
90N-Glycan biosynthesis_Homo sapiens_hsa005100.34494931
91Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33493293
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33175191
93Steroid biosynthesis_Homo sapiens_hsa001000.32742793
94Nitrogen metabolism_Homo sapiens_hsa009100.32304741
95Alcoholism_Homo sapiens_hsa050340.31810186
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31392190
97Arginine and proline metabolism_Homo sapiens_hsa003300.30205290
98Mineral absorption_Homo sapiens_hsa049780.30191746
99Allograft rejection_Homo sapiens_hsa053300.29855471
100Graft-versus-host disease_Homo sapiens_hsa053320.29330198
101Rheumatoid arthritis_Homo sapiens_hsa053230.29178828
102Vitamin digestion and absorption_Homo sapiens_hsa049770.28508687
103Asthma_Homo sapiens_hsa053100.27754434
104Antigen processing and presentation_Homo sapiens_hsa046120.27287382
105Steroid hormone biosynthesis_Homo sapiens_hsa001400.26356175
106Selenocompound metabolism_Homo sapiens_hsa004500.26336121
107Drug metabolism - other enzymes_Homo sapiens_hsa009830.25017703
108Autoimmune thyroid disease_Homo sapiens_hsa053200.24995963
109Galactose metabolism_Homo sapiens_hsa000520.20830628
110Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.20826886
111Viral carcinogenesis_Homo sapiens_hsa052030.20391052
112NOD-like receptor signaling pathway_Homo sapiens_hsa046210.20093766
113Collecting duct acid secretion_Homo sapiens_hsa049660.19192678
114Type I diabetes mellitus_Homo sapiens_hsa049400.19007872
115Thyroid cancer_Homo sapiens_hsa052160.17956287
116Carbon metabolism_Homo sapiens_hsa012000.17786890
117Hedgehog signaling pathway_Homo sapiens_hsa043400.17166991
118Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.17085998
119Starch and sucrose metabolism_Homo sapiens_hsa005000.17005193
120Fructose and mannose metabolism_Homo sapiens_hsa000510.16219539
121Biosynthesis of amino acids_Homo sapiens_hsa012300.15314389
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.15296129
123Other glycan degradation_Homo sapiens_hsa005110.14417318
124Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.13407504
125Cyanoamino acid metabolism_Homo sapiens_hsa004600.12602136
126Tyrosine metabolism_Homo sapiens_hsa003500.11557974
127Intestinal immune network for IgA production_Homo sapiens_hsa046720.11359878
128Hematopoietic cell lineage_Homo sapiens_hsa046400.11205907
129Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.11021418
130RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.10866021
131Phagosome_Homo sapiens_hsa041450.09484108
132HTLV-I infection_Homo sapiens_hsa051660.09049096
133Apoptosis_Homo sapiens_hsa042100.07562424
134Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.05903462
135Shigellosis_Homo sapiens_hsa051310.04682984
136Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.04138550

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