DPAGT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an enzyme that catalyzes the first step in the dolichol-linked oligosaccharide pathway for glycoprotein biosynthesis. This enzyme belongs to the glycosyltransferase family 4. This protein is an integral membrane protein of the endoplasmic reticulum. The congenital disorder of glycosylation type Ij is caused by mutation in the gene encoding this enzyme. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.10799714
2negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.74842425
3regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.48950809
4positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.47353001
5regulation of cellular amino acid metabolic process (GO:0006521)4.45422526
6GDP-mannose metabolic process (GO:0019673)4.41614410
7establishment of integrated proviral latency (GO:0075713)4.40266956
8negative regulation of ligase activity (GO:0051352)4.32348273
9negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.32348273
10DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.31814373
11establishment of viral latency (GO:0019043)4.29811103
12anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.27785945
13signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.25667474
14signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.25667474
15signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.25667474
16signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.25665708
17intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.25665708
18ribosomal small subunit assembly (GO:0000028)4.21873669
19signal transduction involved in DNA damage checkpoint (GO:0072422)4.14126548
20signal transduction involved in DNA integrity checkpoint (GO:0072401)4.14126548
21protein maturation by protein folding (GO:0022417)4.10822844
22signal transduction involved in cell cycle checkpoint (GO:0072395)4.08463418
23ribosome assembly (GO:0042255)3.99331441
24positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.81189693
25* dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.72474138
26rRNA modification (GO:0000154)3.72096455
27endosome to melanosome transport (GO:0035646)3.70641452
28endosome to pigment granule transport (GO:0043485)3.70641452
29positive regulation of ligase activity (GO:0051351)3.66095011
30maturation of 5.8S rRNA (GO:0000460)3.62047514
31purine nucleobase biosynthetic process (GO:0009113)3.60465755
32nucleotide-sugar biosynthetic process (GO:0009226)3.54830704
33IMP biosynthetic process (GO:0006188)3.53272154
34antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.50430344
35viral mRNA export from host cell nucleus (GO:0046784)3.49652341
36high-density lipoprotein particle remodeling (GO:0034375)3.47008196
37tRNA aminoacylation for protein translation (GO:0006418)3.45437701
38lipopolysaccharide biosynthetic process (GO:0009103)3.45399769
39regulation of ubiquitin-protein transferase activity (GO:0051438)3.42200172
40cullin deneddylation (GO:0010388)3.37619415
41killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.36157049
42disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.36157049
43tricarboxylic acid cycle (GO:0006099)3.34273260
44protein deneddylation (GO:0000338)3.33241012
45nucleobase biosynthetic process (GO:0046112)3.31246082
46regulation of ligase activity (GO:0051340)3.31184580
47tRNA aminoacylation (GO:0043039)3.31183680
48amino acid activation (GO:0043038)3.31183680
49telomere maintenance via semi-conservative replication (GO:0032201)3.28701950
50regulation of cellular amine metabolic process (GO:0033238)3.26704469
51DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.25828989
52signal peptide processing (GO:0006465)3.23192393
53erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.22802299
54L-phenylalanine metabolic process (GO:0006558)3.22802299
55mannosylation (GO:0097502)3.20541167
56COPI coating of Golgi vesicle (GO:0048205)3.19909950
57Golgi transport vesicle coating (GO:0048200)3.19909950
58antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.19776916
59negative regulation of cholesterol transport (GO:0032375)3.17989587
60negative regulation of sterol transport (GO:0032372)3.17989587
61positive regulation of cell cycle arrest (GO:0071158)3.17660834
62erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.15037512
63L-phenylalanine catabolic process (GO:0006559)3.15037512
64mitotic nuclear envelope disassembly (GO:0007077)3.14438480
65rRNA methylation (GO:0031167)3.08459837
66mitotic sister chromatid segregation (GO:0000070)3.07398423
67negative regulation of protein ubiquitination (GO:0031397)3.06657593
68reverse cholesterol transport (GO:0043691)2.99995173
69DNA replication checkpoint (GO:0000076)2.98026844
70chaperone-mediated protein transport (GO:0072321)2.97934383
71sulfur amino acid catabolic process (GO:0000098)2.97044285
72aromatic amino acid family catabolic process (GO:0009074)2.95926250
73maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.93885961
74nuclear envelope disassembly (GO:0051081)2.91441123
75membrane disassembly (GO:0030397)2.91441123
76plasma lipoprotein particle remodeling (GO:0034369)2.91042655
77protein-lipid complex remodeling (GO:0034368)2.91042655
78macromolecular complex remodeling (GO:0034367)2.91042655
79signal transduction in response to DNA damage (GO:0042770)2.90985233
80triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.90907019
81valine metabolic process (GO:0006573)2.89904321
82one-carbon metabolic process (GO:0006730)2.89258684
83negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.89189307
84transcription elongation from RNA polymerase III promoter (GO:0006385)2.87337042
85termination of RNA polymerase III transcription (GO:0006386)2.87337042
86antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.87028819
87spliceosomal snRNP assembly (GO:0000387)2.86072552
88IMP metabolic process (GO:0046040)2.85872966
89pseudouridine synthesis (GO:0001522)2.83600842
90protein retention in ER lumen (GO:0006621)2.83480987
91DNA deamination (GO:0045006)2.83390872
92lipopolysaccharide metabolic process (GO:0008653)2.82743139
93peptidyl-glutamic acid carboxylation (GO:0017187)2.82363108
94protein carboxylation (GO:0018214)2.82363108
95complement activation, alternative pathway (GO:0006957)2.82265189
96killing of cells of other organism (GO:0031640)2.80846410
97disruption of cells of other organism (GO:0044364)2.80846410
98regulation of mitochondrial translation (GO:0070129)2.79623721
99antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.79406986
100antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.79406986
101cell cycle G1/S phase transition (GO:0044843)2.78962887
102G1/S transition of mitotic cell cycle (GO:0000082)2.78962887
103tryptophan catabolic process (GO:0006569)2.78273653
104indole-containing compound catabolic process (GO:0042436)2.78273653
105indolalkylamine catabolic process (GO:0046218)2.78273653
106nuclear pore organization (GO:0006999)2.77579706
107peptidyl-histidine modification (GO:0018202)2.75521509
108formation of translation preinitiation complex (GO:0001731)2.73459259
109respiratory chain complex IV assembly (GO:0008535)2.72683676
110DNA ligation (GO:0006266)2.72150913
111folic acid-containing compound biosynthetic process (GO:0009396)2.72141435
112oxidative phosphorylation (GO:0006119)2.71831342
113NADH metabolic process (GO:0006734)2.71625677
114regulation of protein activation cascade (GO:2000257)2.71351651
115regulation of cholesterol biosynthetic process (GO:0045540)2.71165834
116negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)2.69221441
117negative regulation of cell cycle G1/S phase transition (GO:1902807)2.69221441
118nucleobase-containing small molecule interconversion (GO:0015949)2.68457819
119sequestering of metal ion (GO:0051238)2.67874255
120aldehyde catabolic process (GO:0046185)2.67751275
121regulation of translational fidelity (GO:0006450)2.67673347
122tryptophan metabolic process (GO:0006568)2.67453541
123regulation of cell cycle arrest (GO:0071156)2.67155947
124glycine metabolic process (GO:0006544)2.67122239
125proline biosynthetic process (GO:0006561)2.66587429
126kynurenine metabolic process (GO:0070189)2.65596966
127L-serine metabolic process (GO:0006563)2.64647726
128mitotic metaphase plate congression (GO:0007080)2.64316691
129nuclear envelope reassembly (GO:0031468)2.62382063
130mitotic nuclear envelope reassembly (GO:0007084)2.62382063
131protein targeting to mitochondrion (GO:0006626)2.61869739
132negative regulation of fibrinolysis (GO:0051918)2.61595599
133DNA catabolic process, exonucleolytic (GO:0000738)2.61591900
134mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.61253508
135branched-chain amino acid catabolic process (GO:0009083)2.61133869
136regulation of complement activation (GO:0030449)2.60705559
137nucleoside salvage (GO:0043174)2.60402249
138pteridine-containing compound biosynthetic process (GO:0042559)2.59665614
139positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.59288906
140galactose catabolic process (GO:0019388)2.58084262
141positive regulation of lipoprotein lipase activity (GO:0051006)2.57034013
142positive regulation of triglyceride lipase activity (GO:0061365)2.57034013
143tetrahydrofolate metabolic process (GO:0046653)2.56439013
144glyoxylate metabolic process (GO:0046487)2.55202447
145purine-containing compound salvage (GO:0043101)2.54878921
1464-hydroxyproline metabolic process (GO:0019471)2.50679891
147exocrine pancreas development (GO:0031017)2.49063665
148complement activation, classical pathway (GO:0006958)2.47020293
149blood coagulation, intrinsic pathway (GO:0007597)2.46826275
150opsonization (GO:0008228)2.44698963
151Arp2/3 complex-mediated actin nucleation (GO:0034314)2.44096206
152regulation of cholesterol metabolic process (GO:0090181)2.43735105
153bile acid biosynthetic process (GO:0006699)2.43503997
154maturation of SSU-rRNA (GO:0030490)2.42982300
155plasma lipoprotein particle clearance (GO:0034381)2.41311274
156cysteine metabolic process (GO:0006534)2.40773990
157histone-serine phosphorylation (GO:0035404)2.39406007
158alpha-linolenic acid metabolic process (GO:0036109)2.38991011
159complement activation (GO:0006956)2.37551799
160antigen processing and presentation of endogenous antigen (GO:0019883)2.37346905
161low-density lipoprotein particle remodeling (GO:0034374)2.37017694
162imidazole-containing compound metabolic process (GO:0052803)2.35513018
163protein activation cascade (GO:0072376)2.35188571
164reactive oxygen species biosynthetic process (GO:1903409)2.35108589
165pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.33365583
166SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.32439593
167serine family amino acid biosynthetic process (GO:0009070)2.31690114
168defense response to fungus (GO:0050832)2.31462718
169folic acid metabolic process (GO:0046655)2.31152509
170platelet dense granule organization (GO:0060155)2.30321580
171fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.29975175
172amino-acid betaine metabolic process (GO:0006577)2.29525338
173DNA strand elongation involved in DNA replication (GO:0006271)2.29126291
174phospholipid efflux (GO:0033700)2.28777539
175plasma lipoprotein particle organization (GO:0071827)2.28713183
176deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.27908946
177regulation of lipoprotein particle clearance (GO:0010984)2.27907346
178folic acid-containing compound metabolic process (GO:0006760)2.27255673
179folic acid transport (GO:0015884)2.26281341
180pteridine-containing compound metabolic process (GO:0042558)2.25224053
181regulation of fibrinolysis (GO:0051917)2.24936061
182purine nucleotide salvage (GO:0032261)2.24690786
183regulation of cholesterol esterification (GO:0010872)2.24534041
184negative regulation of phagocytosis (GO:0050765)2.22949295
185cotranslational protein targeting to membrane (GO:0006613)2.21003132
186protein targeting to ER (GO:0045047)2.20326181
187DNA strand elongation (GO:0022616)2.19700518
188urea cycle (GO:0000050)2.17604962

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.31568247
2E2F7_22180533_ChIP-Seq_HELA_Human3.72203817
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.42080362
4* ELF1_17652178_ChIP-ChIP_JURKAT_Human3.02444854
5CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.77512431
6RXR_22158963_ChIP-Seq_LIVER_Mouse2.72593617
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.71260236
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.67480974
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.63783970
10* CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.52594961
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.49653635
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.47764303
13* EST1_17652178_ChIP-ChIP_JURKAT_Human2.29218226
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.22786814
15EGR1_23403033_ChIP-Seq_LIVER_Mouse2.19923451
16* GABP_17652178_ChIP-ChIP_JURKAT_Human2.17315003
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.17150617
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.14162312
19* CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.11486968
20* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.09148925
21IRF8_21731497_ChIP-ChIP_J774_Mouse2.08095484
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.07284782
23* ETS1_20019798_ChIP-Seq_JURKAT_Human2.03482147
24EGR1_19374776_ChIP-ChIP_THP-1_Human2.00313075
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.95170269
26FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.91747668
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.88279787
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.84556937
29MYB_21317192_ChIP-Seq_ERMYB_Mouse1.79150681
30MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.77435731
31* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.76146458
32GATA1_22025678_ChIP-Seq_K562_Human1.75980993
33HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.75737702
34FOXM1_23109430_ChIP-Seq_U2OS_Human1.72309667
35CREB1_15753290_ChIP-ChIP_HEK293T_Human1.71809179
36LXR_22158963_ChIP-Seq_LIVER_Mouse1.71363167
37TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.71058231
38* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.69856284
39RBPJ_22232070_ChIP-Seq_NCS_Mouse1.68034373
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.65805980
41MYC_22102868_ChIP-Seq_BL_Human1.65657999
42* TTF2_22483619_ChIP-Seq_HELA_Human1.61243977
43E2F4_17652178_ChIP-ChIP_JURKAT_Human1.58272646
44VDR_23849224_ChIP-Seq_CD4+_Human1.57300948
45E2F1_18555785_ChIP-Seq_MESCs_Mouse1.57170249
46SPI1_23547873_ChIP-Seq_NB4_Human1.57123765
47KDM5A_27292631_Chip-Seq_BREAST_Human1.57008603
48* SRF_21415370_ChIP-Seq_HL-1_Mouse1.54765904
49* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.54280191
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.53076906
51* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.53075702
52* FOXP3_21729870_ChIP-Seq_TREG_Human1.51213075
53SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.50879342
54* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50738814
55* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.49356629
56MYC_19079543_ChIP-ChIP_MESCs_Mouse1.49259675
57SCL_19346495_ChIP-Seq_HPC-7_Human1.48934930
58SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.48602542
59STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.47909257
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47048797
61DCP1A_22483619_ChIP-Seq_HELA_Human1.44648955
62ERG_20887958_ChIP-Seq_HPC-7_Mouse1.44128059
63HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.44083063
64FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.43589475
65* XRN2_22483619_ChIP-Seq_HELA_Human1.43333281
66HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.41764789
67* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.40885238
68VDR_21846776_ChIP-Seq_THP-1_Human1.40645992
69MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40385914
70NELFA_20434984_ChIP-Seq_ESCs_Mouse1.38759294
71GABP_19822575_ChIP-Seq_HepG2_Human1.38068781
72NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.36296507
73* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.35931106
74PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.35755825
75* CIITA_25753668_ChIP-Seq_RAJI_Human1.33910872
76FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.31110613
77RARG_19884340_ChIP-ChIP_MEFs_Mouse1.29129001
78STAT3_1855785_ChIP-Seq_MESCs_Mouse1.27600467
79TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.27096619
80HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.26702284
81DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.26393703
82BRD4_27068464_Chip-Seq_AML-cells_Mouse1.25935621
83TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25396044
84ZFX_18555785_ChIP-Seq_MESCs_Mouse1.24189785
85DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.21611988
86PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.20023614
87TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19543758
88IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.17404335
89SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.17088439
90IRF8_27001747_Chip-Seq_BMDM_Mouse1.16911839
91TFEB_21752829_ChIP-Seq_HELA_Human1.16613614
92GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.16292484
93GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15875609
94BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.15371190
95E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15237853
96ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.13386809
97ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09951595
98ELK1_22589737_ChIP-Seq_MCF10A_Human1.09694714
99* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.08261586
100LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.08148900
101CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.07963428
102NANOG_18555785_ChIP-Seq_MESCs_Mouse1.07232387
103E2F1_21310950_ChIP-Seq_MCF-7_Human1.06789564
104KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.06281564
105ZNF263_19887448_ChIP-Seq_K562_Human1.05634870
106RUNX1_22412390_ChIP-Seq_EML_Mouse1.05486691
107MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.04994270
108MYB_26560356_Chip-Seq_TH2_Human1.04665973
109ELK1_19687146_ChIP-ChIP_HELA_Human1.03602014
110* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.03007287
111GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02448006
112* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.01457990
113SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.00865823
114* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.99462498
115THAP11_20581084_ChIP-Seq_MESCs_Mouse0.99204127
116CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.98452535
117* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.97953689
118KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97804034
119POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.97547458
120* ELF5_23300383_ChIP-Seq_T47D_Human0.96670307
121SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.96449026
122AR_21909140_ChIP-Seq_LNCAP_Human0.96361640
123MYB_26560356_Chip-Seq_TH1_Human0.96157391
124CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95662916
125* YY1_21170310_ChIP-Seq_MESCs_Mouse0.95379955
126* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95094310
127GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95055384
128CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94643261
129ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.94086867
130THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93562098
131MYC_18940864_ChIP-ChIP_HL60_Human0.89137821
132* SOX17_20123909_ChIP-Seq_XEN_Mouse0.86597375
133TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.83700003
134CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.83611429
135SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.81172520
136HIF1A_21447827_ChIP-Seq_MCF-7_Human0.77983029
137CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.77938822
138CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.75993175

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair4.12238107
2MP0002139_abnormal_hepatobiliary_system3.87470404
3MP0009840_abnormal_foam_cell3.49419628
4MP0005365_abnormal_bile_salt3.36060533
5MP0005360_urolithiasis3.26309681
6MP0003718_maternal_effect3.13331944
7MP0005408_hypopigmentation3.10960437
8MP0005085_abnormal_gallbladder_physiolo3.08889637
9MP0003806_abnormal_nucleotide_metabolis2.46806450
10MP0008932_abnormal_embryonic_tissue2.29828316
11MP0003436_decreased_susceptibility_to2.29155895
12MP0006054_spinal_hemorrhage2.22428648
13* MP0003693_abnormal_embryo_hatching2.18672623
14MP0005083_abnormal_biliary_tract2.17948144
15MP0003941_abnormal_skin_development2.14409077
16MP0001835_abnormal_antigen_presentation2.12998820
17MP0003786_premature_aging2.12858791
18MP0001666_abnormal_nutrient_absorption2.06861586
19MP0008875_abnormal_xenobiotic_pharmacok1.96526641
20MP0003191_abnormal_cellular_cholesterol1.93600281
21MP0002396_abnormal_hematopoietic_system1.87019401
22MP0010329_abnormal_lipoprotein_level1.81508441
23MP0001730_embryonic_growth_arrest1.77358192
24MP0005464_abnormal_platelet_physiology1.73960168
25MP0003186_abnormal_redox_activity1.72825303
26MP0005395_other_phenotype1.68349203
27MP0000372_irregular_coat_pigmentation1.66813705
28MP0002419_abnormal_innate_immunity1.62335228
29MP0001881_abnormal_mammary_gland1.61542879
30MP0003172_abnormal_lysosome_physiology1.61534641
31MP0005025_abnormal_response_to1.60392131
32MP0009697_abnormal_copulation1.58996995
33MP0003724_increased_susceptibility_to1.58278904
34MP0009333_abnormal_splenocyte_physiolog1.57744592
35MP0009785_altered_susceptibility_to1.56349760
36MP0005332_abnormal_amino_acid1.55009992
37MP0000358_abnormal_cell_content/1.54359641
38MP0001853_heart_inflammation1.54141808
39MP0002148_abnormal_hypersensitivity_rea1.52731371
40MP0006035_abnormal_mitochondrial_morpho1.50926999
41MP0000609_abnormal_liver_physiology1.50923760
42MP0001764_abnormal_homeostasis1.49805079
43MP0002736_abnormal_nociception_after1.48909669
44MP0005319_abnormal_enzyme/_coenzyme1.47772581
45MP0004147_increased_porphyrin_level1.47375294
46MP0005451_abnormal_body_composition1.43145082
47MP0002006_tumorigenesis1.40420171
48MP0003656_abnormal_erythrocyte_physiolo1.38410129
49MP0003252_abnormal_bile_duct1.33625338
50MP0000343_altered_response_to1.33489293
51MP0001529_abnormal_vocalization1.33454748
52MP0005075_abnormal_melanosome_morpholog1.33286150
53MP0002796_impaired_skin_barrier1.30628468
54MP0008469_abnormal_protein_level1.30033796
55MP0000598_abnormal_liver_morphology1.28867421
56MP0000490_abnormal_crypts_of1.27885237
57MP0010368_abnormal_lymphatic_system1.27737592
58MP0005220_abnormal_exocrine_pancreas1.27273860
59MP0009643_abnormal_urine_homeostasis1.25507976
60MP0000685_abnormal_immune_system1.24708164
61MP0002254_reproductive_system_inflammat1.23027984
62MP0001672_abnormal_embryogenesis/_devel1.22938169
63MP0005380_embryogenesis_phenotype1.22938169
64MP0010234_abnormal_vibrissa_follicle1.22550274
65MP0000350_abnormal_cell_proliferation1.21404666
66MP0001845_abnormal_inflammatory_respons1.19753832
67MP0005501_abnormal_skin_physiology1.19717918
68MP0004808_abnormal_hematopoietic_stem1.19484738
69MP0002938_white_spotting1.19209875
70* MP0002080_prenatal_lethality1.19073299
71MP0001697_abnormal_embryo_size1.18382365
72MP0002452_abnormal_antigen_presenting1.17592495
73MP0010155_abnormal_intestine_physiology1.15748493
74MP0005000_abnormal_immune_tolerance1.13183555
75MP0001800_abnormal_humoral_immune1.11816298
76MP0003984_embryonic_growth_retardation1.10147297
77MP0000313_abnormal_cell_death1.10055352
78MP0004782_abnormal_surfactant_physiolog1.09579952
79MP0001533_abnormal_skeleton_physiology1.09287168
80MP0004019_abnormal_vitamin_homeostasis1.09059984
81MP0002420_abnormal_adaptive_immunity1.08981076
82MP0001819_abnormal_immune_cell1.08844931
83MP0003195_calcinosis1.08629508
84MP0005084_abnormal_gallbladder_morpholo1.08431197
85MP0005397_hematopoietic_system_phenotyp1.08341976
86MP0001545_abnormal_hematopoietic_system1.08341976
87MP0000858_altered_metastatic_potential1.08229296
88MP0003705_abnormal_hypodermis_morpholog1.08130952
89MP0002723_abnormal_immune_serum1.07385646
90MP0002118_abnormal_lipid_homeostasis1.06268781
91MP0002877_abnormal_melanocyte_morpholog1.05500042
92MP0004957_abnormal_blastocyst_morpholog1.04034234
93MP0009763_increased_sensitivity_to1.04017902
94MP0008007_abnormal_cellular_replicative1.03714697
95MP0002398_abnormal_bone_marrow1.02690335
96MP0002405_respiratory_system_inflammati1.02492103
97MP0002138_abnormal_hepatobiliary_system1.02191920
98MP0002088_abnormal_embryonic_growth/wei1.01783026
99MP0005058_abnormal_lysosome_morphology1.00608439
100MP0000249_abnormal_blood_vessel0.99721754
101MP0009764_decreased_sensitivity_to0.99602973
102MP0002429_abnormal_blood_cell0.97878949
103MP0005387_immune_system_phenotype0.97697582
104MP0001790_abnormal_immune_system0.97697582
105MP0001873_stomach_inflammation0.97094504
106MP0005165_increased_susceptibility_to0.96760700
107MP0010094_abnormal_chromosome_stability0.95827988
108MP0008057_abnormal_DNA_replication0.94962058
109MP0000689_abnormal_spleen_morphology0.94367799
110MP0003077_abnormal_cell_cycle0.93879516
111MP0005671_abnormal_response_to0.92784337
112MP0005023_abnormal_wound_healing0.92717294
113MP0003183_abnormal_peptide_metabolism0.92619673
114MP0000716_abnormal_immune_system0.92253322
115MP0003868_abnormal_feces_composition0.92103980
116MP0000467_abnormal_esophagus_morphology0.92063633
117MP0000627_abnormal_mammary_gland0.91980018
118MP0004264_abnormal_extraembryonic_tissu0.91818140
119MP0001727_abnormal_embryo_implantation0.91222397
120MP0002166_altered_tumor_susceptibility0.91029202
121MP0008872_abnormal_physiological_respon0.90368370
122MP0003943_abnormal_hepatobiliary_system0.90251810
123MP0001879_abnormal_lymphatic_vessel0.90188760
124MP0005584_abnormal_enzyme/coenzyme_acti0.89229463
125MP0005174_abnormal_tail_pigmentation0.88067156
126MP0003763_abnormal_thymus_physiology0.87841968
127MP0005670_abnormal_white_adipose0.85915500
128MP0008873_increased_physiological_sensi0.85683175
129MP0005384_cellular_phenotype0.83871692
130MP0002722_abnormal_immune_system0.83719124
131MP0003890_abnormal_embryonic-extraembry0.83380068
132MP0000015_abnormal_ear_pigmentation0.83192766
133MP0006036_abnormal_mitochondrial_physio0.82004039
134MP0005636_abnormal_mineral_homeostasis0.81622833
135MP0002132_abnormal_respiratory_system0.80485671
136MP0005410_abnormal_fertilization0.80223355
137MP0003300_gastrointestinal_ulcer0.78592995
138MP0003950_abnormal_plasma_membrane0.78226268
139MP0003111_abnormal_nucleus_morphology0.77815976
140MP0001756_abnormal_urination0.76787239
141MP0009642_abnormal_blood_homeostasis0.76353974
142MP0001216_abnormal_epidermal_layer0.76304261
143MP0004233_abnormal_muscle_weight0.75855536
144MP0002060_abnormal_skin_morphology0.75813749
145MP0010352_gastrointestinal_tract_polyps0.75808275
146MP0002019_abnormal_tumor_incidence0.75120586
147MP0003303_peritoneal_inflammation0.74253320
148MP0000613_abnormal_salivary_gland0.72487353
149MP0003315_abnormal_perineum_morphology0.72031410
150MP0001243_abnormal_dermal_layer0.71610417
151MP0002086_abnormal_extraembryonic_tissu0.71555082
152MP0005621_abnormal_cell_physiology0.70252643
153MP0001661_extended_life_span0.70054876
154MP0010771_integument_phenotype0.65970149
155MP0002085_abnormal_embryonic_tissue0.65654588
156MP0004272_abnormal_basement_membrane0.65585831
157MP0002168_other_aberrant_phenotype0.64588338

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)3.92697829
2Methylmalonic acidemia (HP:0002912)3.89832895
3Vacuolated lymphocytes (HP:0001922)3.73902858
4Abnormality of glycolysis (HP:0004366)3.71144804
5Cholecystitis (HP:0001082)3.66834156
6Abnormal gallbladder physiology (HP:0012438)3.66834156
7Abnormality of monocarboxylic acid metabolism (HP:0010996)3.62576163
8Systemic lupus erythematosus (HP:0002725)3.59361919
9Methylmalonic aciduria (HP:0012120)3.57481574
10Abnormality of the intrinsic pathway (HP:0010989)3.45857237
11Increased serum pyruvate (HP:0003542)3.45542246
12Meckel diverticulum (HP:0002245)3.38805140
13Abnormality of the common coagulation pathway (HP:0010990)3.35993699
14Chromosomal breakage induced by crosslinking agents (HP:0003221)3.33032056
15Abnormality of the ileum (HP:0001549)3.31571490
16Abnormality of the preputium (HP:0100587)3.30616858
17Hypoglycemic coma (HP:0001325)3.28726717
18Deep venous thrombosis (HP:0002625)3.22915985
19Hepatocellular necrosis (HP:0001404)3.22338008
20Chromsome breakage (HP:0040012)3.21183448
21Intrahepatic cholestasis (HP:0001406)3.19229931
22Acute encephalopathy (HP:0006846)3.18878501
23Abnormal mitochondria in muscle tissue (HP:0008316)3.11900813
24Hypobetalipoproteinemia (HP:0003563)3.11456379
25Recurrent gram-negative bacterial infections (HP:0005420)3.07358495
26Acute necrotizing encephalopathy (HP:0006965)3.06196178
27Complement deficiency (HP:0004431)3.04285242
28Hepatic necrosis (HP:0002605)3.00828950
29Joint hemorrhage (HP:0005261)2.99104947
30Microvesicular hepatic steatosis (HP:0001414)2.98589065
31Thrombocytosis (HP:0001894)2.97477111
32Abnormality of pyrimidine metabolism (HP:0004353)2.97444060
33Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.96320904
34Decreased activity of mitochondrial respiratory chain (HP:0008972)2.96320904
35Hypoplasia of the pons (HP:0012110)2.92868640
36Prolonged partial thromboplastin time (HP:0003645)2.90051892
37Conjugated hyperbilirubinemia (HP:0002908)2.90008242
38Xanthomatosis (HP:0000991)2.89129141
39Abnormality of the pons (HP:0007361)2.86440486
40Rough bone trabeculation (HP:0100670)2.85326245
41Abnormality of complement system (HP:0005339)2.85183240
42* Reduced antithrombin III activity (HP:0001976)2.77483821
43Aplasia/Hypoplasia of the uvula (HP:0010293)2.75881275
44Pancytopenia (HP:0001876)2.72435096
45Abnormality of DNA repair (HP:0003254)2.72400313
46Mitochondrial inheritance (HP:0001427)2.71933002
47Increased CSF lactate (HP:0002490)2.70017334
48Beaking of vertebral bodies (HP:0004568)2.67381002
49Testicular atrophy (HP:0000029)2.64981085
50Hyperbilirubinemia (HP:0002904)2.63750017
51Hyperglycinemia (HP:0002154)2.62757598
52Generalized aminoaciduria (HP:0002909)2.61841507
53Hyperammonemia (HP:0001987)2.60965368
54Glomerulonephritis (HP:0000099)2.59742005
55Abnormality of methionine metabolism (HP:0010901)2.59562158
56Abnormality of sulfur amino acid metabolism (HP:0004339)2.59310490
57CNS demyelination (HP:0007305)2.59265833
58Small intestinal stenosis (HP:0012848)2.59122325
59Duodenal stenosis (HP:0100867)2.59122325
60Late onset (HP:0003584)2.58990578
61Abnormality of aspartate family amino acid metabolism (HP:0010899)2.56993038
62Hyperlipoproteinemia (HP:0010980)2.50660636
63Eczematoid dermatitis (HP:0000976)2.50508488
64Increased serum lactate (HP:0002151)2.49802103
65Abnormality of the vitamin B12 metabolism (HP:0004341)2.46424282
66Recurrent bacterial skin infections (HP:0005406)2.45001816
67Cerebral edema (HP:0002181)2.42687770
68Abnormality of chromosome stability (HP:0003220)2.41729602
69Hyperglycinuria (HP:0003108)2.40427900
70Elevated erythrocyte sedimentation rate (HP:0003565)2.38438956
71Hypolipoproteinemia (HP:0010981)2.38427123
72Recurrent abscess formation (HP:0002722)2.37769281
73Exercise intolerance (HP:0003546)2.37619509
74Progressive macrocephaly (HP:0004481)2.37298493
75Vascular calcification (HP:0004934)2.37239916
76Aplastic anemia (HP:0001915)2.37024208
77Abnormality of vitamin B metabolism (HP:0004340)2.36083209
78Fat malabsorption (HP:0002630)2.35941822
79Palpitations (HP:0001962)2.34805217
80Menorrhagia (HP:0000132)2.34212811
81Abnormality of serum amino acid levels (HP:0003112)2.33925734
82Urinary glycosaminoglycan excretion (HP:0003541)2.33312645
83Mucopolysacchariduria (HP:0008155)2.33312645
84Nephritis (HP:0000123)2.32490052
85Abnormality of fatty-acid metabolism (HP:0004359)2.30226430
86Entropion (HP:0000621)2.30193086
87Lactic acidosis (HP:0003128)2.29341871
88Abnormality of dicarboxylic acid metabolism (HP:0010995)2.28783657
89Dicarboxylic aciduria (HP:0003215)2.28783657
90Abnormal umbilical cord blood vessels (HP:0011403)2.27134727
91Single umbilical artery (HP:0001195)2.27134727
92Abnormality of the fetal cardiovascular system (HP:0010948)2.27134727
93Sparse eyelashes (HP:0000653)2.27072298
94Nausea (HP:0002018)2.26659191
95Autoimmune thrombocytopenia (HP:0001973)2.26600273
96Abnormal gallbladder morphology (HP:0012437)2.25515696
97Cerebral hypomyelination (HP:0006808)2.25352341
98Basal ganglia calcification (HP:0002135)2.24394350
99Abnormality of mucopolysaccharide metabolism (HP:0011020)2.23769697
100Abnormality of polysaccharide metabolism (HP:0011012)2.23769697
101Abnormality of glycosaminoglycan metabolism (HP:0004371)2.23769697
102Petechiae (HP:0000967)2.22612634
103Epistaxis (HP:0000421)2.21648747
104Abnormal platelet function (HP:0011869)2.21237490
105Impaired platelet aggregation (HP:0003540)2.21237490
106Abnormal trabecular bone morphology (HP:0100671)2.20931305
107Abnormality of the umbilical cord (HP:0010881)2.20620396
108Myelodysplasia (HP:0002863)2.20402185
109Cholelithiasis (HP:0001081)2.19337791
110Esophageal varix (HP:0002040)2.18474766
111Polycythemia (HP:0001901)2.18316803
112Vertebral compression fractures (HP:0002953)2.16888910
113Cardiovascular calcification (HP:0011915)2.16093048
114Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.12695251
115Ketosis (HP:0001946)2.11035041
116Abnormality of nucleobase metabolism (HP:0010932)2.10490071
117Lethargy (HP:0001254)2.10263245
118Opisthotonus (HP:0002179)2.10121433
119IgM deficiency (HP:0002850)2.10085034
120Hypoglycemic seizures (HP:0002173)2.10020049
121Steatorrhea (HP:0002570)2.09343007
122Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.08669548
123Pancreatic islet-cell hyperplasia (HP:0004510)2.07701824
124Gingival bleeding (HP:0000225)2.07367183
125* Abnormal protein glycosylation (HP:0012346)2.07065193
126* Abnormal glycosylation (HP:0012345)2.07065193
127* Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.07065193
128* Abnormal protein N-linked glycosylation (HP:0012347)2.07065193
129Myocardial infarction (HP:0001658)2.05760490
130Spontaneous hematomas (HP:0007420)2.05620687
131Abnormality of glycine metabolism (HP:0010895)2.05570050
132Abnormality of serine family amino acid metabolism (HP:0010894)2.05570050
133Abnormality of the duodenum (HP:0002246)2.04597320
134Abnormality of homocysteine metabolism (HP:0010919)2.04385956
135Homocystinuria (HP:0002156)2.04385956
136Nonimmune hydrops fetalis (HP:0001790)2.03560757
137Biconcave vertebral bodies (HP:0004586)2.02693190
138Hypoalphalipoproteinemia (HP:0003233)2.01848552
139Purpura (HP:0000979)2.01010534
140* Type I transferrin isoform profile (HP:0003642)2.00600237
141Abnormality of macrophages (HP:0004311)1.99522400
142Pancreatitis (HP:0001733)1.97614731
143Abnormal number of erythroid precursors (HP:0012131)1.97406819
144Abnormality of vitamin metabolism (HP:0100508)1.96439374
145Dysostosis multiplex (HP:0000943)1.95296793
146Cortical dysplasia (HP:0002539)1.93604060
147Megaloblastic anemia (HP:0001889)1.93512447
148Oral leukoplakia (HP:0002745)1.93326202
149Abnormality of the gallbladder (HP:0005264)1.91442241
150Ragged-red muscle fibers (HP:0003200)1.91012309
151Hypokinesia (HP:0002375)1.89252014
152Abnormalities of placenta or umbilical cord (HP:0001194)1.88759885
153Neoplasm of the adrenal gland (HP:0100631)1.88640478
154Clubbing of toes (HP:0100760)1.88327182
155Reticulocytopenia (HP:0001896)1.87813522
156Adrenal hypoplasia (HP:0000835)1.87279376
157Spastic paraparesis (HP:0002313)1.86397704
158Poor head control (HP:0002421)1.85046107
159Secondary amenorrhea (HP:0000869)1.84462168
160Prolonged bleeding time (HP:0003010)1.84070441
161Myositis (HP:0100614)1.82758285
162Abnormality of the anterior horn cell (HP:0006802)1.82127061
163Degeneration of anterior horn cells (HP:0002398)1.82127061
164Cervical subluxation (HP:0003308)1.81833276
165Respiratory failure (HP:0002878)1.80997774
166Renal Fanconi syndrome (HP:0001994)1.80776826
167Horseshoe kidney (HP:0000085)1.79992337
168Periodontitis (HP:0000704)1.79836565
169Bone marrow hypocellularity (HP:0005528)1.79200121
170Myopathic facies (HP:0002058)1.78714940
171Abnormality of cells of the erythroid lineage (HP:0012130)1.78632473
172Abnormality of glutamine family amino acid metabolism (HP:0010902)1.78604855
173Premature ovarian failure (HP:0008209)1.76930588
174Oligomenorrhea (HP:0000876)1.76855712
175Gout (HP:0001997)1.76706496
176Abnormal lung lobation (HP:0002101)1.75698802
177Epiphyseal stippling (HP:0010655)1.73979003
178Emotional lability (HP:0000712)1.72270259

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.34463206
2ERN14.37776956
3BRSK23.20786227
4MST42.99426558
5STK162.83200024
6TSSK62.81745786
7BCKDK2.73696290
8NME22.72435738
9EPHA32.62745703
10IRAK42.49909185
11TTK2.37103764
12FLT32.35121276
13CAMKK22.33796838
14BLK2.26536634
15EPHA22.12188478
16KDR2.07860055
17NME12.05451787
18PLK31.93585005
19MAP4K11.91108627
20ZAP701.84364174
21TRIB31.84187346
22PKN21.78163495
23PDK21.72223180
24PBK1.71525883
25BUB11.71355026
26IRAK31.70209516
27TGFBR11.65636889
28BRD41.64596491
29TGFBR21.61535327
30EIF2AK11.57734826
31TRIM281.55597321
32RPS6KA41.55084567
33TIE11.52883872
34BRSK11.50386449
35TAOK21.48271002
36PIM21.45827271
37ZAK1.45330605
38MKNK11.43762856
39BTK1.35651514
40KIT1.31936595
41TYK21.29681701
42WEE11.29566784
43EIF2AK31.28151347
44ABL21.27449954
45LIMK11.24997010
46TBK11.23457020
47TEC1.18868027
48JAK31.10055257
49LATS11.09997077
50INSRR1.09658643
51SMG11.09146521
52PAK41.07647197
53NEK91.06614459
54MAP2K31.03134205
55MAP4K21.02548582
56TAF11.02208276
57TAOK30.99806585
58PASK0.98435133
59FGFR40.98390812
60CDC70.98118711
61CCNB10.96405009
62PIM10.94947276
63DAPK10.93903007
64CSNK1G30.93441709
65TRPM70.92516207
66PRKCI0.91364277
67PTK60.91051825
68CHEK20.90367921
69TESK20.89400515
70MAPKAPK50.89256625
71PLK40.86059365
72LYN0.85306104
73SRPK10.85233410
74NEK10.85093190
75MAP3K140.84979346
76SIK30.83433600
77CSF1R0.82764138
78MAP3K110.80858960
79NEK20.80828044
80ACVR1B0.80826858
81CLK10.79505886
82LRRK20.78145577
83CSNK1A1L0.77572314
84WNK30.77182331
85CDK40.76931494
86IRAK20.74714235
87TXK0.73020733
88PRPF4B0.72007288
89PIK3CG0.70847082
90CDK70.69076944
91FER0.66519860
92MAP3K120.64712076
93ERBB40.63873913
94IKBKE0.63575457
95EEF2K0.63231974
96MAPKAPK30.62960487
97IKBKB0.62608576
98SYK0.61527254
99MATK0.59087350
100STK40.58761598
101RPS6KB20.58597009
102MAPK110.58458650
103VRK10.58382580
104PDGFRA0.57547466
105STK100.57541309
106CSNK1G10.56901060
107AURKB0.56681108
108CHEK10.55867439
109SIK10.55717290
110AURKA0.54013632
111CSNK2A10.51430993
112ATM0.51320134
113TESK10.50329290
114MKNK20.50025939
115ATR0.49777009
116MST1R0.48944252
117NLK0.48607905
118MAP3K30.48343685
119CDK60.47089337
120CSNK1G20.46736442
121BCR0.46714815
122ILK0.46285697
123CSNK2A20.46280219
124MYLK0.46256835
125LMTK20.45147093
126CDK80.44082845
127CHUK0.42803315
128PRKG20.42767487
129EIF2AK20.42323441
130MAP3K80.41888337
131PAK10.40218018
132MARK30.40134512
133MAPKAPK20.39479266
134ERBB30.38755670
135JAK20.38714121
136PTK20.37781405
137MET0.37277058
138PLK10.37171819
139SCYL20.37055253
140STK240.36442577
141JAK10.36270899
142LCK0.35743058
143NUAK10.35319249
144MAP3K50.32990766
145CSNK1A10.31086003
146GRK10.29659638
147RPS6KA50.27771998
148YES10.27296706
149PRKDC0.27021727
150PLK20.27009938
151MUSK0.25217255
152CDK10.24367793
153BRAF0.22910308

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001202.62225799
2Protein export_Homo sapiens_hsa030602.20866823
3DNA replication_Homo sapiens_hsa030302.15226126
4Sulfur metabolism_Homo sapiens_hsa009202.13016739
5Complement and coagulation cascades_Homo sapiens_hsa046102.11734372
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.09254204
7Staphylococcus aureus infection_Homo sapiens_hsa051502.05394767
8One carbon pool by folate_Homo sapiens_hsa006702.04577310
9Folate biosynthesis_Homo sapiens_hsa007902.03086125
10Caffeine metabolism_Homo sapiens_hsa002322.02932968
11Selenocompound metabolism_Homo sapiens_hsa004502.01489512
12Drug metabolism - other enzymes_Homo sapiens_hsa009831.95283716
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.92648650
14Pentose and glucuronate interconversions_Homo sapiens_hsa000401.89684567
15Sulfur relay system_Homo sapiens_hsa041221.84503723
16Proteasome_Homo sapiens_hsa030501.79592348
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.76327731
18Ribosome_Homo sapiens_hsa030101.72834600
19Fanconi anemia pathway_Homo sapiens_hsa034601.69632898
20Other glycan degradation_Homo sapiens_hsa005111.66935497
21Mismatch repair_Homo sapiens_hsa034301.66313728
22Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.60694163
23Steroid biosynthesis_Homo sapiens_hsa001001.58160004
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.57034263
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.52521317
26Tryptophan metabolism_Homo sapiens_hsa003801.52472727
27Fatty acid degradation_Homo sapiens_hsa000711.52082201
28Oxidative phosphorylation_Homo sapiens_hsa001901.50789737
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.37527121
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.36892486
31Base excision repair_Homo sapiens_hsa034101.36709560
32Peroxisome_Homo sapiens_hsa041461.34967934
33Pyrimidine metabolism_Homo sapiens_hsa002401.33751727
34Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.30230559
35ABC transporters_Homo sapiens_hsa020101.28078038
36Glycosaminoglycan degradation_Homo sapiens_hsa005311.27680120
37Galactose metabolism_Homo sapiens_hsa000521.24345459
38Arginine biosynthesis_Homo sapiens_hsa002201.23232379
39Parkinsons disease_Homo sapiens_hsa050121.22647262
40Histidine metabolism_Homo sapiens_hsa003401.20686862
41Fat digestion and absorption_Homo sapiens_hsa049751.20623833
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.20533897
43beta-Alanine metabolism_Homo sapiens_hsa004101.15612763
44Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.14290453
45Vitamin B6 metabolism_Homo sapiens_hsa007501.13048877
46Propanoate metabolism_Homo sapiens_hsa006401.11200064
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.10135012
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.09986444
49Legionellosis_Homo sapiens_hsa051341.09844794
50Pentose phosphate pathway_Homo sapiens_hsa000301.09498446
51* N-Glycan biosynthesis_Homo sapiens_hsa005101.06155982
52Carbon metabolism_Homo sapiens_hsa012001.05406008
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.04156136
54RNA degradation_Homo sapiens_hsa030181.04017450
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.99787531
56Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.99106503
57Leishmaniasis_Homo sapiens_hsa051400.98950755
58Purine metabolism_Homo sapiens_hsa002300.98687487
59Starch and sucrose metabolism_Homo sapiens_hsa005000.98129864
60Biosynthesis of amino acids_Homo sapiens_hsa012300.94153822
61Lysosome_Homo sapiens_hsa041420.93015567
62Chemical carcinogenesis_Homo sapiens_hsa052040.91793585
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91598603
64Spliceosome_Homo sapiens_hsa030400.91480500
65Arginine and proline metabolism_Homo sapiens_hsa003300.91370936
66Pyruvate metabolism_Homo sapiens_hsa006200.91012341
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.89287684
68Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.88374264
69Huntingtons disease_Homo sapiens_hsa050160.88051211
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86875190
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84254981
72RNA polymerase_Homo sapiens_hsa030200.83901236
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83161516
74Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.82050618
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.80401619
76Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78112782
77Herpes simplex infection_Homo sapiens_hsa051680.76840773
78Basal transcription factors_Homo sapiens_hsa030220.75028794
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.74240358
80Vitamin digestion and absorption_Homo sapiens_hsa049770.74063683
81Pertussis_Homo sapiens_hsa051330.72518709
82PPAR signaling pathway_Homo sapiens_hsa033200.72135676
83Glutathione metabolism_Homo sapiens_hsa004800.70506565
84Retinol metabolism_Homo sapiens_hsa008300.70232203
85Measles_Homo sapiens_hsa051620.70211419
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.69371763
87Fatty acid metabolism_Homo sapiens_hsa012120.66939585
88Vibrio cholerae infection_Homo sapiens_hsa051100.65326021
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.63547622
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61312600
91RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60830793
92Alzheimers disease_Homo sapiens_hsa050100.58344670
93Antigen processing and presentation_Homo sapiens_hsa046120.57737003
94Phenylalanine metabolism_Homo sapiens_hsa003600.56826097
95Cell cycle_Homo sapiens_hsa041100.56507057
96p53 signaling pathway_Homo sapiens_hsa041150.56231818
97Homologous recombination_Homo sapiens_hsa034400.55752803
98Regulation of autophagy_Homo sapiens_hsa041400.55331010
99Influenza A_Homo sapiens_hsa051640.53784509
100RNA transport_Homo sapiens_hsa030130.53489605
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52516158
102SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51271660
103* Metabolic pathways_Homo sapiens_hsa011000.50556335
104Toll-like receptor signaling pathway_Homo sapiens_hsa046200.49085225
105Butanoate metabolism_Homo sapiens_hsa006500.49031857
106Renin-angiotensin system_Homo sapiens_hsa046140.46911535
107Shigellosis_Homo sapiens_hsa051310.45189858
108Intestinal immune network for IgA production_Homo sapiens_hsa046720.44954820
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43597768
110Arachidonic acid metabolism_Homo sapiens_hsa005900.42513642
111mRNA surveillance pathway_Homo sapiens_hsa030150.42167650
112Tyrosine metabolism_Homo sapiens_hsa003500.40504020
113Apoptosis_Homo sapiens_hsa042100.40188084
114Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39952391
115Fructose and mannose metabolism_Homo sapiens_hsa000510.39597306
116Nucleotide excision repair_Homo sapiens_hsa034200.39439010
117Sphingolipid metabolism_Homo sapiens_hsa006000.38387760
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.37635657
119Epstein-Barr virus infection_Homo sapiens_hsa051690.36912043
120Non-homologous end-joining_Homo sapiens_hsa034500.35937577
121Oocyte meiosis_Homo sapiens_hsa041140.35762644
122Fatty acid elongation_Homo sapiens_hsa000620.32978483
123Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.26274325
124Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25410287
125Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24568146

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