DOCK10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family are guanosine nucleotide exchange factors for Rho GTPases and defined by the presence of conserved DOCK-homology regions. The encoded protein belongs to the D (or Zizimin) subfamily of DOCK proteins, which also contain an N-terminal pleckstrin homology domain. Alternatively spliced transcript variants that encode different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.88191322
2positive regulation of gamma-delta T cell activation (GO:0046645)6.46548680
3negative regulation of cell killing (GO:0031342)5.52669509
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.52669509
5regulation of B cell receptor signaling pathway (GO:0050855)5.25577255
6negative T cell selection (GO:0043383)5.21552812
7negative thymic T cell selection (GO:0045060)5.12259232
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.87680721
9positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.74750718
10regulation of gamma-delta T cell activation (GO:0046643)4.72993138
11telomere maintenance via semi-conservative replication (GO:0032201)4.61909188
12positive thymic T cell selection (GO:0045059)4.59203778
13regulation of gamma-delta T cell differentiation (GO:0045586)4.57424122
14positive T cell selection (GO:0043368)4.55568188
15L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.50709644
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.41262742
17respiratory chain complex IV assembly (GO:0008535)4.29679135
18positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.26281595
19antigen processing and presentation of endogenous antigen (GO:0019883)4.23629723
20antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.16461284
21deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.13617592
22T cell migration (GO:0072678)4.12361686
23T cell selection (GO:0045058)4.10356283
24negative regulation of T cell mediated immunity (GO:0002710)4.00436989
25proteasome assembly (GO:0043248)3.97693991
26telomere maintenance via recombination (GO:0000722)3.97422283
27thymic T cell selection (GO:0045061)3.96967654
28DNA strand elongation involved in DNA replication (GO:0006271)3.96019474
29B cell receptor signaling pathway (GO:0050853)3.89504837
30modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.88691681
31positive regulation by organism of defense response of other organism involved in symbiotic interact3.88691681
32modulation by symbiont of host immune response (GO:0052553)3.88691681
33positive regulation by symbiont of host defense response (GO:0052509)3.88691681
34modulation by symbiont of host defense response (GO:0052031)3.88691681
35modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.88691681
36protein deneddylation (GO:0000338)3.88303503
37cellular extravasation (GO:0045123)3.86645101
38response to interleukin-15 (GO:0070672)3.82276196
39negative regulation of interleukin-12 production (GO:0032695)3.82097678
40DNA strand elongation (GO:0022616)3.81761812
41cytochrome complex assembly (GO:0017004)3.81437294
42cullin deneddylation (GO:0010388)3.81267196
43activated T cell proliferation (GO:0050798)3.77697453
44tolerance induction (GO:0002507)3.71688241
45leukocyte aggregation (GO:0070486)3.71620256
46termination of RNA polymerase III transcription (GO:0006386)3.70564100
47transcription elongation from RNA polymerase III promoter (GO:0006385)3.70564100
48ribosomal small subunit assembly (GO:0000028)3.70557674
49tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.70207368
50RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.70207368
51regulation of T cell tolerance induction (GO:0002664)3.64554874
52cellular response to interleukin-15 (GO:0071350)3.62654242
53DNA replication initiation (GO:0006270)3.62030756
54macrophage activation involved in immune response (GO:0002281)3.59590467
55interferon-gamma production (GO:0032609)3.59234122
56pseudouridine synthesis (GO:0001522)3.56532758
57positive regulation of B cell differentiation (GO:0045579)3.56102700
58protein complex biogenesis (GO:0070271)3.55381103
59positive regulation of granulocyte differentiation (GO:0030854)3.54893702
60regulation of mitochondrial translation (GO:0070129)3.54522085
61iron-sulfur cluster assembly (GO:0016226)3.53194751
62metallo-sulfur cluster assembly (GO:0031163)3.53194751
63regulation of B cell differentiation (GO:0045577)3.46343323
64mitotic recombination (GO:0006312)3.41580176
65negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.39759405
66amino acid salvage (GO:0043102)3.39112300
67L-methionine salvage (GO:0071267)3.39112300
68L-methionine biosynthetic process (GO:0071265)3.39112300
69negative regulation of lymphocyte mediated immunity (GO:0002707)3.38334934
70regulation of alpha-beta T cell proliferation (GO:0046640)3.38074748
71regulation of tolerance induction (GO:0002643)3.35614435
72telomere maintenance via telomere lengthening (GO:0010833)3.33813609
73detection of other organism (GO:0098543)3.33712980
74mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.32091365
75mitochondrial respiratory chain complex I assembly (GO:0032981)3.32091365
76NADH dehydrogenase complex assembly (GO:0010257)3.32091365
77deoxyribose phosphate biosynthetic process (GO:0046385)3.30518522
782-deoxyribonucleotide biosynthetic process (GO:0009265)3.30518522
79interferon-gamma-mediated signaling pathway (GO:0060333)3.29972325
80type I interferon signaling pathway (GO:0060337)3.29753801
81cellular response to type I interferon (GO:0071357)3.29753801
82response to type I interferon (GO:0034340)3.28468659
83mitochondrial respiratory chain complex assembly (GO:0033108)3.28357565
84rRNA modification (GO:0000154)3.27950668
85regulation of interleukin-2 biosynthetic process (GO:0045076)3.27009452
86regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.26297428
87antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.25410330
88response to muramyl dipeptide (GO:0032495)3.25302800
89DNA replication checkpoint (GO:0000076)3.21499104
90GDP-mannose metabolic process (GO:0019673)3.20802192
91tRNA methylation (GO:0030488)3.19572214
92signal peptide processing (GO:0006465)3.14579554
93immunoglobulin mediated immune response (GO:0016064)3.14501139
94signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.14086841
95signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.14086841
96signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.14086841
97response to peptidoglycan (GO:0032494)3.14079092
98detection of bacterium (GO:0016045)3.13303381
99antigen receptor-mediated signaling pathway (GO:0050851)3.12692756
100mannosylation (GO:0097502)3.12625132
1017-methylguanosine mRNA capping (GO:0006370)3.11965370
102negative regulation of leukocyte mediated immunity (GO:0002704)3.11368589
103regulation of cellular amino acid metabolic process (GO:0006521)3.11164466
104DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.10311857
105cellular response to ethanol (GO:0071361)3.10238610
106positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.10216922
107positive regulation of alpha-beta T cell proliferation (GO:0046641)3.09369963
108regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.08924367
109detection of molecule of bacterial origin (GO:0032490)3.07164043
110regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.06512305
111nucleobase biosynthetic process (GO:0046112)3.06482227
112negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.06098542
113negative regulation of ligase activity (GO:0051352)3.06098542
114RNA capping (GO:0036260)3.05965426
1157-methylguanosine RNA capping (GO:0009452)3.05965426
116microglial cell activation (GO:0001774)3.05627729
117signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.05585798
118intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.05585798
119regulation of nuclear cell cycle DNA replication (GO:0033262)3.04887106
120antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.03702756
121ribosome biogenesis (GO:0042254)3.03464986
122histone H2A acetylation (GO:0043968)3.02759957
123myeloid cell activation involved in immune response (GO:0002275)3.02675118
124deoxyribonucleotide biosynthetic process (GO:0009263)3.02017014
125positive regulation of tolerance induction (GO:0002645)3.01903837
126rRNA methylation (GO:0031167)3.01318390
127purine nucleobase biosynthetic process (GO:0009113)3.00444647
128neutrophil activation involved in immune response (GO:0002283)2.99956563
129T cell receptor signaling pathway (GO:0050852)2.99060638
130anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.98777205
131detection of external biotic stimulus (GO:0098581)2.97217681
132transcription-coupled nucleotide-excision repair (GO:0006283)2.95812016
133T cell costimulation (GO:0031295)2.95619303
134pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.95613860
135presynaptic membrane assembly (GO:0097105)2.94938990
136regulation of dendritic cell antigen processing and presentation (GO:0002604)2.94825151
137signal transduction involved in DNA damage checkpoint (GO:0072422)2.94060165
138signal transduction involved in DNA integrity checkpoint (GO:0072401)2.94060165
139NIK/NF-kappaB signaling (GO:0038061)2.93321411
140lymphocyte costimulation (GO:0031294)2.91446803
141regulation of isotype switching to IgG isotypes (GO:0048302)2.91394382
142signal transduction involved in cell cycle checkpoint (GO:0072395)2.91303913
143mast cell activation (GO:0045576)2.89108223
144regulation of interferon-beta biosynthetic process (GO:0045357)2.88041925
145platelet dense granule organization (GO:0060155)2.87754047
146exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.87718655
147antigen processing and presentation via MHC class Ib (GO:0002475)2.87625061
148pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.86495120
149positive regulation of interleukin-2 production (GO:0032743)2.84875702
150positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.84788634
151nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.84579371
152positive regulation of mast cell activation (GO:0033005)2.84318226
153nucleotide-excision repair, DNA gap filling (GO:0006297)2.83879473
154T cell proliferation (GO:0042098)2.83648592
155regulation of regulatory T cell differentiation (GO:0045589)2.82716760
156maturation of SSU-rRNA (GO:0030490)2.82710826
157defense response to protozoan (GO:0042832)2.82286366
158regulation of antigen processing and presentation (GO:0002577)2.81958267
159maturation of 5.8S rRNA (GO:0000460)2.81807117
160myeloid dendritic cell activation (GO:0001773)2.81320820
161positive regulation of antigen processing and presentation (GO:0002579)2.81100041
162regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.80779555
163tRNA processing (GO:0008033)2.78970877
164intra-S DNA damage checkpoint (GO:0031573)2.78394352
165germinal center formation (GO:0002467)2.78287708
166CENP-A containing nucleosome assembly (GO:0034080)2.76895166
167positive regulation of B cell mediated immunity (GO:0002714)2.76762269
168positive regulation of immunoglobulin mediated immune response (GO:0002891)2.76762269
169regulation of natural killer cell mediated immunity (GO:0002715)2.76454183
170regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.76454183
171B cell homeostasis (GO:0001782)2.76223884
172phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.75450161
173negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.74821744
174regulation of alpha-beta T cell activation (GO:0046634)2.74590887
175tRNA modification (GO:0006400)2.73690285
176positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.73616700
177postsynaptic membrane organization (GO:0001941)2.73245977
178negative regulation of transcription by competitive promoter binding (GO:0010944)2.73185409
179dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.73086326
180response to host immune response (GO:0052572)2.72886652
181response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.72886652
182cellular component biogenesis (GO:0044085)2.71201312
183peptidyl-histidine modification (GO:0018202)2.70217622
184methionine biosynthetic process (GO:0009086)2.69873933
185RNA methylation (GO:0001510)2.69649297
186regulation of T cell mediated cytotoxicity (GO:0001914)2.69397307
187positive regulation of isotype switching (GO:0045830)2.69330913
188positive regulation of humoral immune response (GO:0002922)2.69199562
189macrophage activation (GO:0042116)2.68695815
190negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.67974637
191ribosome assembly (GO:0042255)2.67591194
192positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.67319682
193DNA catabolic process, exonucleolytic (GO:0000738)2.67157993
194chaperone-mediated protein transport (GO:0072321)2.66864421
195response to interferon-beta (GO:0035456)2.66351988
196deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.66341825
197ribonucleoprotein complex biogenesis (GO:0022613)2.64721997
198chromatin remodeling at centromere (GO:0031055)2.62901176
199positive regulation of protein homodimerization activity (GO:0090073)2.62739489
200guanosine-containing compound biosynthetic process (GO:1901070)2.62171605

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.15197757
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.70343762
3E2F7_22180533_ChIP-Seq_HELA_Human4.70342266
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.28925628
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.06537828
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.03561871
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.86152994
8RUNX_20019798_ChIP-Seq_JUKART_Human3.58729537
9MYC_18555785_ChIP-Seq_MESCs_Mouse3.58050684
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.55306881
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.50663320
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.45035582
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.39164235
14BP1_19119308_ChIP-ChIP_Hs578T_Human3.37573931
15ELF1_17652178_ChIP-ChIP_JURKAT_Human3.33814490
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.31862924
17* IRF8_27001747_Chip-Seq_BMDM_Mouse3.20099457
18* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.17022206
19SMAD_19615063_ChIP-ChIP_OVARY_Human3.15498227
20ETS1_20019798_ChIP-Seq_JURKAT_Human3.13427866
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.02308733
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.89652483
23* MYB_26560356_Chip-Seq_TH2_Human2.82536962
24* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.75332230
25SRF_21415370_ChIP-Seq_HL-1_Mouse2.74680134
26* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.67428118
27VDR_23849224_ChIP-Seq_CD4+_Human2.65682773
28THAP11_20581084_ChIP-Seq_MESCs_Mouse2.59187535
29VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.52640745
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.51747592
31MYC_19030024_ChIP-ChIP_MESCs_Mouse2.48083709
32FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.47957727
33CREB1_15753290_ChIP-ChIP_HEK293T_Human2.45826471
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.43822294
35PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.36533344
36FOXP3_21729870_ChIP-Seq_TREG_Human2.35836786
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.32905188
38* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.30564655
39* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.24619467
40E2F1_18555785_ChIP-Seq_MESCs_Mouse2.22468479
41YY1_21170310_ChIP-Seq_MESCs_Mouse2.21770425
42* MYB_26560356_Chip-Seq_TH1_Human2.19505499
43NOTCH1_21737748_ChIP-Seq_TLL_Human2.12742885
44CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.12498959
45SPI1_23127762_ChIP-Seq_K562_Human2.11044872
46HOXB4_20404135_ChIP-ChIP_EML_Mouse2.10107590
47TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.08860649
48VDR_24787735_ChIP-Seq_THP-1_Human2.08501511
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.07897016
50BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.07748083
51E2F4_17652178_ChIP-ChIP_JURKAT_Human2.07704054
52* MAF_26560356_Chip-Seq_TH1_Human2.06686219
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.06080694
54DCP1A_22483619_ChIP-Seq_HELA_Human2.03946117
55GABP_19822575_ChIP-Seq_HepG2_Human2.03512560
56NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.02652170
57MYC_19079543_ChIP-ChIP_MESCs_Mouse2.00932737
58ERG_20887958_ChIP-Seq_HPC-7_Mouse1.96122196
59VDR_24763502_ChIP-Seq_THP-1_Human1.94708907
60GATA3_27048872_Chip-Seq_THYMUS_Human1.94333745
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.89383674
62NELFA_20434984_ChIP-Seq_ESCs_Mouse1.88879731
63E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.82841957
64* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.81697045
65YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80471123
66ELK1_19687146_ChIP-ChIP_HELA_Human1.80111878
67XRN2_22483619_ChIP-Seq_HELA_Human1.78199783
68MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.77810479
69MYC_22102868_ChIP-Seq_BL_Human1.74231426
70UTX_26944678_Chip-Seq_JUKART_Human1.71525065
71EGR1_19374776_ChIP-ChIP_THP-1_Human1.71064293
72ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.69936681
73RBPJ_22232070_ChIP-Seq_NCS_Mouse1.69348503
74RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.69201258
75IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.68734645
76FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.66532258
77NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.64520939
78* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.64452307
79TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63490203
80RUNX1_22412390_ChIP-Seq_EML_Mouse1.63399249
81VDR_21846776_ChIP-Seq_THP-1_Human1.60187366
82SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.60006313
83CIITA_25753668_ChIP-Seq_RAJI_Human1.59903457
84GATA1_22025678_ChIP-Seq_K562_Human1.59878121
85GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.57897318
86MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.57534003
87* GATA3_26560356_Chip-Seq_TH2_Human1.56972181
88TTF2_22483619_ChIP-Seq_HELA_Human1.54619567
89SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.53645645
90* PU_27001747_Chip-Seq_BMDM_Mouse1.50782191
91NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.48705734
92* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.47448800
93MYCN_18555785_ChIP-Seq_MESCs_Mouse1.45251968
94MAF_26560356_Chip-Seq_TH2_Human1.42459833
95KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.41852657
96POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.41833471
97* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.41461836
98TCF7_22412390_ChIP-Seq_EML_Mouse1.39156325
99CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.37239668
100ZFX_18555785_ChIP-Seq_MESCs_Mouse1.34104118
101KDM2B_26808549_Chip-Seq_SUP-B15_Human1.33058025
102SPI1_23547873_ChIP-Seq_NB4_Human1.32184726
103GATA1_19941827_ChIP-Seq_MEL_Mouse1.31322169
104RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.30726992
105SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.29121382
106NANOG_18555785_ChIP-Seq_MESCs_Mouse1.28571528
107MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.28534456
108E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.26530109
109PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25534793
110TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.23573372
111STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.23468532
112* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22366692
113* GATA2_21666600_ChIP-Seq_HMVEC_Human1.21075766
114* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.18538979
115PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16969911
116IRF1_19129219_ChIP-ChIP_H3396_Human1.16610400
117ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16109651
118* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13578523
119MYC_18940864_ChIP-ChIP_HL60_Human1.13328431
120KDM2B_26808549_Chip-Seq_DND41_Human1.12652076
121IRF8_22096565_ChIP-ChIP_GC-B_Human1.12376313
122E2F1_21310950_ChIP-Seq_MCF-7_Human1.09440626
123DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09327615
124CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07318538
125LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06795504
126GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05915922
127CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05429475
128GATA1_19941826_ChIP-Seq_K562_Human1.05279533
129KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04216912
130SCL_19346495_ChIP-Seq_HPC-7_Human1.03152262
131FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02186926
132GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00488232
133ELK1_22589737_ChIP-Seq_MCF10A_Human1.00004581
134CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96046706
135ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95120887
136HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.95093090
137BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94568639
138KDM2B_26808549_Chip-Seq_JURKAT_Human0.94547616
139SMRT_27268052_Chip-Seq_Bcells_Human0.93933475
140CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.93773105
141CTCF_18555785_ChIP-Seq_MESCs_Mouse0.91551838
142POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.90744942
143GATA2_19941826_ChIP-Seq_K562_Human0.90586329
144CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89841826
145CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86937523
146KDM5A_27292631_Chip-Seq_BREAST_Human0.86911209
147TFEB_21752829_ChIP-Seq_HELA_Human0.86855932
148GBX2_23144817_ChIP-Seq_PC3_Human0.85914904
149CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.85881512
150GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.85368685
151E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.85241017
152PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82623030
153VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.82345336
154PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82115485
155CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.81132148
156IGF1R_20145208_ChIP-Seq_DFB_Human0.81130396
157EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.80136031
158PU.1_20513432_ChIP-Seq_Bcells_Mouse0.79500867
159SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.79216264
160STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.74622143
161PRDM14_20953172_ChIP-Seq_ESCs_Human0.72451550
162CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.71519584
163BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.71204407
164IRF8_21731497_ChIP-ChIP_J774_Mouse0.70564079
165GATA1_19941827_ChIP-Seq_MEL86_Mouse0.70198625
166GATA1_22383799_ChIP-Seq_G1ME_Mouse0.69368877
167TBX5_21415370_ChIP-Seq_HL-1_Mouse0.67099106
168CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.66909003
169* PCGF2_27294783_Chip-Seq_ESCs_Mouse0.66627470
170* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.65802514
171MYB_21317192_ChIP-Seq_ERMYB_Mouse0.64490694
172* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.63739911
173* FLI1_27457419_Chip-Seq_LIVER_Mouse0.63122943
174GATA3_26560356_Chip-Seq_TH1_Human0.62145276
175ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.62041826
176TP53_16413492_ChIP-PET_HCT116_Human0.59252217
177TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.58949566

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.31603764
2MP0003693_abnormal_embryo_hatching3.11637665
3MP0001188_hyperpigmentation3.11393366
4MP0008058_abnormal_DNA_repair3.04597059
5MP0005075_abnormal_melanosome_morpholog2.91450048
6MP0005387_immune_system_phenotype2.88056071
7MP0001790_abnormal_immune_system2.88056071
8MP0001986_abnormal_taste_sensitivity2.85819286
9MP0003303_peritoneal_inflammation2.84578178
10MP0000015_abnormal_ear_pigmentation2.75429946
11MP0003300_gastrointestinal_ulcer2.74902458
12MP0003183_abnormal_peptide_metabolism2.66981407
13MP0002396_abnormal_hematopoietic_system2.63290649
14MP0006082_CNS_inflammation2.61056676
15MP0000569_abnormal_digit_pigmentation2.58532452
16MP0010094_abnormal_chromosome_stability2.31538972
17MP0005174_abnormal_tail_pigmentation2.31386901
18MP0004147_increased_porphyrin_level2.26931972
19MP0002095_abnormal_skin_pigmentation2.20511682
20MP0008260_abnormal_autophagy2.14349066
21MP0008877_abnormal_DNA_methylation2.10222143
22MP0003172_abnormal_lysosome_physiology2.08242311
23MP0002876_abnormal_thyroid_physiology2.06862299
24MP0002405_respiratory_system_inflammati2.05585658
25MP0008007_abnormal_cellular_replicative2.03765412
26MP0002166_altered_tumor_susceptibility1.92912583
27MP0003111_abnormal_nucleus_morphology1.91271897
28MP0003724_increased_susceptibility_to1.83618713
29MP0004957_abnormal_blastocyst_morpholog1.83016242
30MP0004947_skin_inflammation1.82028813
31MP0001835_abnormal_antigen_presentation1.78684513
32MP0001533_abnormal_skeleton_physiology1.78057721
33MP0003077_abnormal_cell_cycle1.77397111
34MP0009379_abnormal_foot_pigmentation1.76095267
35MP0003787_abnormal_imprinting1.75757377
36MP0008057_abnormal_DNA_replication1.75477972
37MP0009697_abnormal_copulation1.73157399
38MP0005310_abnormal_salivary_gland1.72782322
39MP0010155_abnormal_intestine_physiology1.72250416
40MP0003880_abnormal_central_pattern1.70709286
41MP0001845_abnormal_inflammatory_respons1.67374000
42MP0003786_premature_aging1.63327836
43MP0000681_abnormal_thyroid_gland1.62993751
44MP0002998_abnormal_bone_remodeling1.58987349
45MP0003690_abnormal_glial_cell1.58525254
46MP0005671_abnormal_response_to1.58305309
47MP0002009_preneoplasia1.57313713
48MP0000490_abnormal_crypts_of1.56647885
49MP0000372_irregular_coat_pigmentation1.56404384
50MP0002736_abnormal_nociception_after1.54810701
51MP0005646_abnormal_pituitary_gland1.53741691
52MP0009785_altered_susceptibility_to1.52963912
53MP0000678_abnormal_parathyroid_gland1.52062843
54MP0006036_abnormal_mitochondrial_physio1.48411613
55MP0005397_hematopoietic_system_phenotyp1.46304048
56MP0001545_abnormal_hematopoietic_system1.46304048
57MP0002006_tumorigenesis1.44484718
58MP0003806_abnormal_nucleotide_metabolis1.43136447
59MP0003879_abnormal_hair_cell1.42629761
60MP0005058_abnormal_lysosome_morphology1.42004473
61MP0002132_abnormal_respiratory_system1.40167509
62MP0000604_amyloidosis1.39897976
63MP0004381_abnormal_hair_follicle1.38321210
64MP0003828_pulmonary_edema1.36757772
65MP0003186_abnormal_redox_activity1.35867882
66MP0001764_abnormal_homeostasis1.34663936
67MP0003191_abnormal_cellular_cholesterol1.33886416
68MP0009278_abnormal_bone_marrow1.33470465
69MP0005171_absent_coat_pigmentation1.32882341
70MP0001968_abnormal_touch/_nociception1.32735189
71MP0003763_abnormal_thymus_physiology1.30566185
72MP0009333_abnormal_splenocyte_physiolog1.29696305
73MP0002160_abnormal_reproductive_system1.28182477
74MP0003091_abnormal_cell_migration1.27400523
75MP0001851_eye_inflammation1.27302321
76MP0008932_abnormal_embryonic_tissue1.26156471
77MP0005084_abnormal_gallbladder_morpholo1.26043447
78MP0000465_gastrointestinal_hemorrhage1.25035633
79MP0008469_abnormal_protein_level1.24032044
80MP0004142_abnormal_muscle_tone1.22719548
81MP0002398_abnormal_bone_marrow1.22309263
82MP0001873_stomach_inflammation1.22033751
83MP0004808_abnormal_hematopoietic_stem1.21745216
84MP0005451_abnormal_body_composition1.21565734
85MP0006035_abnormal_mitochondrial_morpho1.21287161
86MP0009764_decreased_sensitivity_to1.19272333
87MP0001853_heart_inflammation1.17426552
88MP0004883_abnormal_blood_vessel1.15812122
89MP0002735_abnormal_chemical_nociception1.15661718
90MP0002148_abnormal_hypersensitivity_rea1.15123401
91MP0003045_fibrosis1.14468765
92MP0003448_altered_tumor_morphology1.13882445
93MP0000858_altered_metastatic_potential1.13408811
94MP0010386_abnormal_urinary_bladder1.08283453
95MP0002933_joint_inflammation1.08216528
96MP0000689_abnormal_spleen_morphology1.07930894
97MP0000920_abnormal_myelination1.06711055
98MP0002420_abnormal_adaptive_immunity1.04854476
99MP0003866_abnormal_defecation1.03369199
100MP0001819_abnormal_immune_cell1.02025633
101MP0003075_altered_response_to1.01197020
102MP0005025_abnormal_response_to1.00779224
103MP0002751_abnormal_autonomic_nervous0.99737930
104MP0001905_abnormal_dopamine_level0.99388826
105MP0004510_myositis0.99146296
106MP0006054_spinal_hemorrhage0.98125058
107MP0001529_abnormal_vocalization0.98100514
108MP0009745_abnormal_behavioral_response0.98048374
109MP0001186_pigmentation_phenotype0.98017309
110MP0000716_abnormal_immune_system0.97357405
111MP0002429_abnormal_blood_cell0.97212760
112MP0002722_abnormal_immune_system0.97009608
113MP0005389_reproductive_system_phenotype0.96474959
114MP0002723_abnormal_immune_serum0.95163014
115MP0002419_abnormal_innate_immunity0.94666968
116MP0002019_abnormal_tumor_incidence0.94569364
117MP0005379_endocrine/exocrine_gland_phen0.93883536
118MP0005166_decreased_susceptibility_to0.93521638
119MP0003656_abnormal_erythrocyte_physiolo0.93212043
120MP0005000_abnormal_immune_tolerance0.91939527
121MP0000358_abnormal_cell_content/0.91474940
122MP0003646_muscle_fatigue0.90975263
123MP0002075_abnormal_coat/hair_pigmentati0.90261828
124MP0003279_aneurysm0.89080810
125MP0000343_altered_response_to0.87901671
126MP0000313_abnormal_cell_death0.87683410
127MP0005164_abnormal_response_to0.86550106
128MP0002638_abnormal_pupillary_reflex0.86109676
129MP0001919_abnormal_reproductive_system0.85919939
130MP0009840_abnormal_foam_cell0.85713509
131MP0005645_abnormal_hypothalamus_physiol0.84997661
132MP0005409_darkened_coat_color0.84180390
133MP0009763_increased_sensitivity_to0.83707822
134MP0002452_abnormal_antigen_presenting0.83583981
135MP0003718_maternal_effect0.83261594
136MP0000249_abnormal_blood_vessel0.80733044
137MP0003436_decreased_susceptibility_to0.80533387
138MP0000685_abnormal_immune_system0.80496474
139MP0002693_abnormal_pancreas_physiology0.79725001
140MP0001958_emphysema0.79542453
141MP0002272_abnormal_nervous_system0.77368876
142MP0002210_abnormal_sex_determination0.77242234
143MP0003123_paternal_imprinting0.77170515
144MP0006276_abnormal_autonomic_nervous0.75209282
145MP0002138_abnormal_hepatobiliary_system0.74972162
146MP0000703_abnormal_thymus_morphology0.74811041
147MP0000371_diluted_coat_color0.74731067
148MP0001800_abnormal_humoral_immune0.73540558
149MP0005464_abnormal_platelet_physiology0.72973536
150MP0003795_abnormal_bone_structure0.69628391
151MP0005390_skeleton_phenotype0.68382665
152MP0009115_abnormal_fat_cell0.67913065
153MP0004130_abnormal_muscle_cell0.66819623
154MP0001663_abnormal_digestive_system0.66233450
155MP0008004_abnormal_stomach_pH0.63063920
156MP0009765_abnormal_xenobiotic_induced0.60127077
157MP0003329_amyloid_beta_deposits0.56629196
158MP0005167_abnormal_blood-brain_barrier0.54814653
159MP0002332_abnormal_exercise_endurance0.53704870
160MP0008874_decreased_physiological_sensi0.53630921
161MP0005621_abnormal_cell_physiology0.47196171

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)5.22558016
2Type I transferrin isoform profile (HP:0003642)4.98669117
3Eczematoid dermatitis (HP:0000976)4.89674361
4Recurrent bacterial skin infections (HP:0005406)4.87271078
5Abnormality of T cell number (HP:0011839)4.82085746
6Aplastic anemia (HP:0001915)4.74221840
7Recurrent abscess formation (HP:0002722)4.51139642
8Recurrent fungal infections (HP:0002841)4.32416321
9Chronic mucocutaneous candidiasis (HP:0002728)4.32195002
10Recurrent cutaneous fungal infections (HP:0011370)4.32195002
11Reduced antithrombin III activity (HP:0001976)4.10193215
12Stomatitis (HP:0010280)4.00731312
13Abnormal delayed hypersensitivity skin test (HP:0002963)3.98947070
14Hepatocellular necrosis (HP:0001404)3.89387507
15Recurrent viral infections (HP:0004429)3.89116433
16Retrobulbar optic neuritis (HP:0100654)3.87475998
17Optic neuritis (HP:0100653)3.87475998
18Abnormality of macrophages (HP:0004311)3.85908094
19Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.77755933
20Abnormal protein N-linked glycosylation (HP:0012347)3.77755933
21Abnormal protein glycosylation (HP:0012346)3.77755933
22Abnormal glycosylation (HP:0012345)3.77755933
23Mediastinal lymphadenopathy (HP:0100721)3.75068443
24Recurrent skin infections (HP:0001581)3.71477961
25Orchitis (HP:0100796)3.69075674
26Spontaneous hematomas (HP:0007420)3.67811598
27Abnormality of T cells (HP:0002843)3.59135293
28Meningitis (HP:0001287)3.56935544
29Hepatic necrosis (HP:0002605)3.40286525
30Vasculitis (HP:0002633)3.39760817
31Birth length less than 3rd percentile (HP:0003561)3.39489250
32Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.38766920
33Decreased activity of mitochondrial respiratory chain (HP:0008972)3.38766920
34Mitochondrial inheritance (HP:0001427)3.31994920
35Pulmonary infiltrates (HP:0002113)3.30419191
36Abnormal mitochondria in muscle tissue (HP:0008316)3.23557279
37Acute necrotizing encephalopathy (HP:0006965)3.22013277
38Pustule (HP:0200039)3.16688978
39Hemoptysis (HP:0002105)3.13189554
40Type 2 muscle fiber atrophy (HP:0003554)3.12228945
41Increased CSF lactate (HP:0002490)3.12192402
42Microvesicular hepatic steatosis (HP:0001414)3.09491508
43Gastrointestinal infarctions (HP:0005244)3.07717909
44Encephalitis (HP:0002383)3.02995035
45Colitis (HP:0002583)3.00671295
46Autoimmune hemolytic anemia (HP:0001890)2.99383759
47Abnormal number of erythroid precursors (HP:0012131)2.97624397
48Recurrent gram-negative bacterial infections (HP:0005420)2.96798725
49Hypothermia (HP:0002045)2.91201163
50Agammaglobulinemia (HP:0004432)2.90966131
51Chronic obstructive pulmonary disease (HP:0006510)2.89731689
52Obstructive lung disease (HP:0006536)2.89731689
53Recurrent bronchitis (HP:0002837)2.89607374
54Leukocytosis (HP:0001974)2.88445974
55Increased serum lactate (HP:0002151)2.88248767
56Pancreatic fibrosis (HP:0100732)2.85951959
57Thrombocytosis (HP:0001894)2.84553870
58Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.84271220
59Abnormality of alanine metabolism (HP:0010916)2.84271220
60Hyperalaninemia (HP:0003348)2.84271220
61Abnormality of the heme biosynthetic pathway (HP:0010472)2.82606063
62IgM deficiency (HP:0002850)2.81820919
63Gingivitis (HP:0000230)2.81624280
64Inflammation of the large intestine (HP:0002037)2.78763935
65Autoimmune thrombocytopenia (HP:0001973)2.72178337
66Muscle fiber atrophy (HP:0100295)2.71775550
67Abnormal hair whorl (HP:0010721)2.69826063
68Chest pain (HP:0100749)2.69087046
69Abnormality of glycolipid metabolism (HP:0010969)2.69067918
70Abnormality of liposaccharide metabolism (HP:0010968)2.69067918
71Abnormality of glycosphingolipid metabolism (HP:0004343)2.69067918
72Abnormality of cells of the erythroid lineage (HP:0012130)2.67959570
73Agnosia (HP:0010524)2.64219845
74True hermaphroditism (HP:0010459)2.62657252
75Keratoconjunctivitis sicca (HP:0001097)2.62579308
76Gastrointestinal inflammation (HP:0004386)2.61090596
77Spondylolisthesis (HP:0003302)2.60799183
78Lymphopenia (HP:0001888)2.59589766
79Abnormality of T cell physiology (HP:0011840)2.58944641
80Granulocytopenia (HP:0001913)2.57790100
81Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.57444770
82IgG deficiency (HP:0004315)2.57075813
83Severe visual impairment (HP:0001141)2.55788256
84Eosinophilia (HP:0001880)2.55356926
85Lactic acidosis (HP:0003128)2.54189397
86Thyroid-stimulating hormone excess (HP:0002925)2.51217294
87Epistaxis (HP:0000421)2.50370496
88Chronic diarrhea (HP:0002028)2.49963347
89Hematochezia (HP:0002573)2.49629024
90Arterial thrombosis (HP:0004420)2.49385747
91Pancreatic cysts (HP:0001737)2.49238715
92Pancytopenia (HP:0001876)2.48483002
93Abnormality of eosinophils (HP:0001879)2.48433658
94Pulmonary embolism (HP:0002204)2.47901539
95Cellulitis (HP:0100658)2.45193343
963-Methylglutaconic aciduria (HP:0003535)2.45104320
97Keratoconjunctivitis (HP:0001096)2.43909924
98Increased cerebral lipofuscin (HP:0011813)2.42653475
99Gingival bleeding (HP:0000225)2.42608101
100Focal motor seizures (HP:0011153)2.42481801
101Abnormality of cells of the lymphoid lineage (HP:0012140)2.42199284
102Slow saccadic eye movements (HP:0000514)2.41979995
103Severe combined immunodeficiency (HP:0004430)2.41409950
104Acute encephalopathy (HP:0006846)2.39175173
105Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.38047533
106Poor suck (HP:0002033)2.37457700
107Reticulocytopenia (HP:0001896)2.35541835
108Dysostosis multiplex (HP:0000943)2.33596797
109Progressive macrocephaly (HP:0004481)2.30911222
110Oral leukoplakia (HP:0002745)2.29954341
111Abnormality of the vasculature of the conjunctiva (HP:0008054)2.29098267
112Chromosomal breakage induced by crosslinking agents (HP:0003221)2.28673753
113Prolonged bleeding time (HP:0003010)2.27830040
114Elevated erythrocyte sedimentation rate (HP:0003565)2.27516373
115Increased hepatocellular lipid droplets (HP:0006565)2.25040440
116Abnormality of the prostate (HP:0008775)2.24992018
117Microretrognathia (HP:0000308)2.23981744
118Exertional dyspnea (HP:0002875)2.23308583
119Viral hepatitis (HP:0006562)2.21126979
120IgA deficiency (HP:0002720)2.20877624
121Cortical visual impairment (HP:0100704)2.20182805
122Exercise intolerance (HP:0003546)2.19442315
123Abnormal spermatogenesis (HP:0008669)2.19242218
124Increased IgE level (HP:0003212)2.18110309
125Papilledema (HP:0001085)2.17654126
126Gastrointestinal stroma tumor (HP:0100723)2.17217051
127Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.17002729
128Nephrogenic diabetes insipidus (HP:0009806)2.16424304
129Increased IgM level (HP:0003496)2.15916414
130Verrucae (HP:0200043)2.14700945
131Papilloma (HP:0012740)2.14700945
132Vacuolated lymphocytes (HP:0001922)2.14292998
133Renal Fanconi syndrome (HP:0001994)2.14062315
134Protruding tongue (HP:0010808)2.13806536
135Epileptic encephalopathy (HP:0200134)2.13188845
136Restrictive lung disease (HP:0002091)2.12261284
137Combined immunodeficiency (HP:0005387)2.11532775
138Osteomyelitis (HP:0002754)2.11200310
139Conjunctival telangiectasia (HP:0000524)2.11198224
140Myositis (HP:0100614)2.11025629
141Hypoplasia of the thymus (HP:0000778)2.10370580
142Loss of speech (HP:0002371)2.09491412
143Urticaria (HP:0001025)2.09382612
144Abnormality of the preputium (HP:0100587)2.09195932
145Medial flaring of the eyebrow (HP:0010747)2.09092071
146Increased intramyocellular lipid droplets (HP:0012240)2.08601632
147Abnormality of the pleura (HP:0002103)2.08230272
148Chromsome breakage (HP:0040012)2.07831707
149Abnormality of the columella (HP:0009929)2.04881718
150Increased neuronal autofluorescent lipopigment (HP:0002074)2.04828096
151Absent rod-and cone-mediated responses on ERG (HP:0007688)2.04357807
152Myelodysplasia (HP:0002863)2.03450697
153Abnormality of the fingertips (HP:0001211)2.03040974
154Abnormality of DNA repair (HP:0003254)2.02585209
155Bone marrow hypocellularity (HP:0005528)2.01243591
156Glomerulopathy (HP:0100820)2.00584722
157Hypergammaglobulinemia (HP:0010702)1.97659174
158Gangrene (HP:0100758)1.96288451
159Fatigue (HP:0012378)1.96272766
160Joint swelling (HP:0001386)1.96031861
161Polyneuropathy (HP:0001271)1.94941437
162Anorexia (HP:0002039)1.94295911
163Amaurosis fugax (HP:0100576)1.93388723
16411 pairs of ribs (HP:0000878)1.91448472
165Congenital primary aphakia (HP:0007707)1.90815753
166Respiratory difficulties (HP:0002880)1.88980648
167Lipid accumulation in hepatocytes (HP:0006561)1.87617064
168Pallor (HP:0000980)1.86779342
169Premature graying of hair (HP:0002216)1.86635907
170Unsteady gait (HP:0002317)1.84151360
171Pulmonary fibrosis (HP:0002206)1.83785317
172Increased CSF protein (HP:0002922)1.83687863
173Acute lymphatic leukemia (HP:0006721)1.83423082
174Aplasia/Hypoplasia of the sacrum (HP:0008517)1.82880443
175Thyroiditis (HP:0100646)1.82295237
176Hyperventilation (HP:0002883)1.82075782
177Petechiae (HP:0000967)1.81670850
178Breast hypoplasia (HP:0003187)1.81265726
179Respiratory failure (HP:0002878)1.79233139
180Self-mutilation (HP:0000742)1.77844007
181Gait imbalance (HP:0002141)1.77539438
182Broad face (HP:0000283)1.75461824
183Aplasia/Hypoplasia of the uvula (HP:0010293)1.72606737
184Meckel diverticulum (HP:0002245)1.72136119
185Abnormality of the ileum (HP:0001549)1.72065610
186Panhypogammaglobulinemia (HP:0003139)1.71605542
187Lymphoma (HP:0002665)1.71325367
188Rough bone trabeculation (HP:0100670)1.70779403
189Neutropenia (HP:0001875)1.70459604
190Hypoplasia of the pons (HP:0012110)1.70252394
191Febrile seizures (HP:0002373)1.69659560
192Cerebral hypomyelination (HP:0006808)1.68091027
193Macrocytic anemia (HP:0001972)1.68005372
194Abnormality of chromosome stability (HP:0003220)1.64925434
195Ragged-red muscle fibers (HP:0003200)1.64892539
196Poor head control (HP:0002421)1.63645281

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.44062237
2STK164.40932916
3EIF2AK33.62318462
4RIPK43.47484236
5TNIK3.07318120
6CCNB13.03748923
7CDK192.85830997
8MAP3K122.80652112
9TYK22.78824850
10MAP3K142.74302982
11JAK12.46525755
12WEE12.41919533
13TAOK32.24176322
14MAP2K72.24026234
15IKBKE2.23225669
16ACVR1B2.19871268
17BUB12.18661490
18MAP3K132.11435585
19CSK2.04282380
20CAMKK22.01463959
21VRK12.00995922
22PIM21.98997039
23ITK1.97270823
24DAPK11.88072739
25TSSK61.85584107
26EIF2AK11.82309140
27IRAK31.73302682
28MKNK21.59465900
29FLT31.56135397
30ZAK1.55299655
31AKT31.54893488
32KIT1.54291883
33NME21.53159038
34FGFR31.51899871
35IRAK41.50528509
36MUSK1.49619589
37BMPR21.49364769
38HCK1.49355283
39LCK1.48995263
40BRSK21.46372651
41TGFBR21.43066669
42GRK61.40840661
43IKBKB1.39576085
44TEC1.37224274
45TBK11.34648261
46FGFR41.33872098
47ADRBK21.32116776
48BRAF1.28684991
49MAPKAPK31.27955410
50PLK41.25486991
51NEK91.23740746
52CDK81.21601813
53FGR1.18076489
54JAK21.17866931
55GRK71.12116281
56SRPK11.10746708
57MKNK11.07916185
58CAMKK11.05564650
59SCYL21.04232382
60TESK21.03646262
61TNK21.02614227
62DYRK31.01522447
63SIK31.01050180
64EIF2AK21.00022248
65MARK30.99807634
66CDK120.96679058
67BMPR1B0.93787438
68STK100.92591403
69CDC42BPA0.92376648
70MAPK70.92013563
71MYLK0.91473587
72BRSK10.91292985
73TRPM70.90276976
74CDK60.90190060
75PDK10.89340450
76ARAF0.89052055
77PRKCQ0.84803230
78NLK0.84553663
79BTK0.83683737
80KDR0.82730628
81NTRK30.82442799
82ATR0.81178525
83TAOK20.80682108
84MAP3K100.80068199
85CDC70.79853126
86PRPF4B0.79767241
87ERN10.79404193
88YES10.78698730
89CDK30.78356978
90TLK10.78351596
91HIPK20.77633000
92MARK20.77590595
93PIM10.76740678
94MAPK110.76237319
95FES0.76101836
96MAPK130.76100178
97MAPK120.75610489
98MELK0.75520946
99BCKDK0.75514286
100CHUK0.73037410
101TXK0.71361924
102MAP3K10.70713630
103EPHB10.68179325
104PDGFRB0.67698751
105ZAP700.67371296
106RPS6KB20.66309926
107MAP3K30.65980966
108SGK30.65104129
109IRAK10.64609074
110WNK10.64420917
111PLK10.62953493
112CDK40.59981447
113PTK2B0.59798704
114CSF1R0.59721678
115CAMK10.58920651
116CDK70.56597071
117PRKCI0.55330477
118SYK0.54860486
119NEK10.54805896
120TYRO30.54125339
121FYN0.53957621
122PASK0.53557684
123MAP3K70.53516632
124MOS0.53462620
125AURKA0.50651221
126MATK0.50195765
127MAP3K110.49887766
128JAK30.49119678
129CAMK1D0.48493518
130BRD40.48170634
131SIK20.47556667
132NME10.47344349
133RET0.46102918
134EGFR0.45627154
135PLK30.45462411
136MAPK150.45256864
137PRKCH0.45220117
138FRK0.45060474
139NEK60.44122774
140PDPK10.42786672
141MAP3K20.41601016
142TTN0.40695517
143CHEK20.40362122
144MAP4K10.39865472
145MAP2K30.39277006
146LYN0.38174392
147ABL10.38015102
148PRKD20.37092884
149CSNK2A10.35575781
150TESK10.35106108
151EPHA30.34431412
152BLK0.33745078
153AURKB0.33222903
154RPS6KA40.32988214
155TTK0.31767873
156STK240.31597491
157KSR20.31462328
158CAMK40.31255966
159PLK20.31070282
160MAP3K50.30958515
161PINK10.30443268
162WNK30.30089586
163RAF10.29556961
164MAP3K40.29164148
165PIK3CG0.27934937
166CSNK2A20.27584477
167MAP2K60.26673828
168SGK20.26551932
169DAPK30.26025361
170PRKCG0.25388121
171DYRK20.25148505

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.41778052
2Proteasome_Homo sapiens_hsa030503.76180774
3Mismatch repair_Homo sapiens_hsa034303.41550317
4RNA polymerase_Homo sapiens_hsa030203.13526289
5Ribosome_Homo sapiens_hsa030103.03934062
6Graft-versus-host disease_Homo sapiens_hsa053322.83215875
7Protein export_Homo sapiens_hsa030602.80886921
8Homologous recombination_Homo sapiens_hsa034402.69182217
9Base excision repair_Homo sapiens_hsa034102.64104632
10Pyrimidine metabolism_Homo sapiens_hsa002402.61785278
11Autoimmune thyroid disease_Homo sapiens_hsa053202.61178390
12Leishmaniasis_Homo sapiens_hsa051402.53637408
13Osteoclast differentiation_Homo sapiens_hsa043802.37973700
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.36442658
15Nucleotide excision repair_Homo sapiens_hsa034202.35052795
16B cell receptor signaling pathway_Homo sapiens_hsa046622.20125819
17Staphylococcus aureus infection_Homo sapiens_hsa051502.16002969
18T cell receptor signaling pathway_Homo sapiens_hsa046602.14652476
19Spliceosome_Homo sapiens_hsa030402.08945675
20Asthma_Homo sapiens_hsa053102.07808388
21Fanconi anemia pathway_Homo sapiens_hsa034602.05500784
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.03217460
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.99789128
24Oxidative phosphorylation_Homo sapiens_hsa001901.96553234
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.86340827
26Basal transcription factors_Homo sapiens_hsa030221.86313230
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.84016807
28Tuberculosis_Homo sapiens_hsa051521.76081604
29Purine metabolism_Homo sapiens_hsa002301.72331765
30Viral myocarditis_Homo sapiens_hsa054161.64533450
31Collecting duct acid secretion_Homo sapiens_hsa049661.60651284
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.60424153
33Toxoplasmosis_Homo sapiens_hsa051451.59371149
34N-Glycan biosynthesis_Homo sapiens_hsa005101.57371534
35SNARE interactions in vesicular transport_Homo sapiens_hsa041301.54243948
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.53931129
37Non-homologous end-joining_Homo sapiens_hsa034501.48164338
38RNA degradation_Homo sapiens_hsa030181.47569601
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.46523615
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.45701462
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.45637292
42Parkinsons disease_Homo sapiens_hsa050121.44757262
43TNF signaling pathway_Homo sapiens_hsa046681.42584276
44Chemokine signaling pathway_Homo sapiens_hsa040621.41686105
45Vibrio cholerae infection_Homo sapiens_hsa051101.38543131
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.38454239
47Acute myeloid leukemia_Homo sapiens_hsa052211.36986685
48RNA transport_Homo sapiens_hsa030131.36825753
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33292410
50Malaria_Homo sapiens_hsa051441.31014804
51Cell cycle_Homo sapiens_hsa041101.28475323
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.28057513
53Regulation of autophagy_Homo sapiens_hsa041401.26888737
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.26157746
55Hepatitis B_Homo sapiens_hsa051611.24583076
56Other glycan degradation_Homo sapiens_hsa005111.21616962
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.20969983
58Folate biosynthesis_Homo sapiens_hsa007901.20413762
59Huntingtons disease_Homo sapiens_hsa050161.19888092
60Non-small cell lung cancer_Homo sapiens_hsa052231.18771280
61Synaptic vesicle cycle_Homo sapiens_hsa047211.15572873
62Platelet activation_Homo sapiens_hsa046111.13758038
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.13227716
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.00954564
65Lysosome_Homo sapiens_hsa041420.99958134
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.99276833
67One carbon pool by folate_Homo sapiens_hsa006700.97367710
68Pancreatic cancer_Homo sapiens_hsa052120.97136767
69Leukocyte transendothelial migration_Homo sapiens_hsa046700.96516901
70Pentose phosphate pathway_Homo sapiens_hsa000300.96442489
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95286870
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.94114844
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.93590171
74Hepatitis C_Homo sapiens_hsa051600.93388469
75Apoptosis_Homo sapiens_hsa042100.91913839
76Prolactin signaling pathway_Homo sapiens_hsa049170.91620458
77Primary immunodeficiency_Homo sapiens_hsa053400.91564008
78Epstein-Barr virus infection_Homo sapiens_hsa051690.91177830
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.90893535
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.90875312
81Chronic myeloid leukemia_Homo sapiens_hsa052200.90650358
82p53 signaling pathway_Homo sapiens_hsa041150.90383675
83Nicotine addiction_Homo sapiens_hsa050330.89378256
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.88996557
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.87827737
86VEGF signaling pathway_Homo sapiens_hsa043700.81915379
87Alzheimers disease_Homo sapiens_hsa050100.80766932
88Dorso-ventral axis formation_Homo sapiens_hsa043200.80523370
89Rheumatoid arthritis_Homo sapiens_hsa053230.80277935
90Circadian rhythm_Homo sapiens_hsa047100.80042374
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.77786143
92Herpes simplex infection_Homo sapiens_hsa051680.77584780
93Renal cell carcinoma_Homo sapiens_hsa052110.76115171
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.75473641
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.73412291
96Inositol phosphate metabolism_Homo sapiens_hsa005620.71363495
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70797093
98HTLV-I infection_Homo sapiens_hsa051660.70705860
99African trypanosomiasis_Homo sapiens_hsa051430.70161882
100Viral carcinogenesis_Homo sapiens_hsa052030.66245006
101mTOR signaling pathway_Homo sapiens_hsa041500.66199223
102Drug metabolism - other enzymes_Homo sapiens_hsa009830.65966885
103Salmonella infection_Homo sapiens_hsa051320.65540635
104FoxO signaling pathway_Homo sapiens_hsa040680.63995194
105Phagosome_Homo sapiens_hsa041450.62765758
106Type I diabetes mellitus_Homo sapiens_hsa049400.61271529
107Antigen processing and presentation_Homo sapiens_hsa046120.59277419
108Legionellosis_Homo sapiens_hsa051340.57955728
109Choline metabolism in cancer_Homo sapiens_hsa052310.57594267
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57391325
111GnRH signaling pathway_Homo sapiens_hsa049120.57013070
112Galactose metabolism_Homo sapiens_hsa000520.56881456
113Colorectal cancer_Homo sapiens_hsa052100.56728649
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56724907
115Endometrial cancer_Homo sapiens_hsa052130.56194731
116Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56070828
117Metabolic pathways_Homo sapiens_hsa011000.55592405
118Sulfur relay system_Homo sapiens_hsa041220.55383102
119MAPK signaling pathway_Homo sapiens_hsa040100.54311044
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53938236
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53635342
122Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52970191
123Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52911499
124Fructose and mannose metabolism_Homo sapiens_hsa000510.52527405
1252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.50786023
126Prostate cancer_Homo sapiens_hsa052150.50537996
127Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50333441
128Endocytosis_Homo sapiens_hsa041440.49648698
129Long-term potentiation_Homo sapiens_hsa047200.49493804
130Renin-angiotensin system_Homo sapiens_hsa046140.49192146
131HIF-1 signaling pathway_Homo sapiens_hsa040660.48812951
132Glioma_Homo sapiens_hsa052140.47727329
133Measles_Homo sapiens_hsa051620.47681284
134Type II diabetes mellitus_Homo sapiens_hsa049300.47555887
135Hematopoietic cell lineage_Homo sapiens_hsa046400.46677189
136Amoebiasis_Homo sapiens_hsa051460.45713350
137ErbB signaling pathway_Homo sapiens_hsa040120.44672852
138Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41279573
139Glutathione metabolism_Homo sapiens_hsa004800.40465378
140Shigellosis_Homo sapiens_hsa051310.40462043
141Arachidonic acid metabolism_Homo sapiens_hsa005900.39794646
142Estrogen signaling pathway_Homo sapiens_hsa049150.39561454
143Ras signaling pathway_Homo sapiens_hsa040140.39329401
144Insulin resistance_Homo sapiens_hsa049310.37883716
145Taste transduction_Homo sapiens_hsa047420.37666539
146Notch signaling pathway_Homo sapiens_hsa043300.36965367
147Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35517433
148Vitamin B6 metabolism_Homo sapiens_hsa007500.34638946
149Rap1 signaling pathway_Homo sapiens_hsa040150.33890549
150Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33484055
151Thyroid cancer_Homo sapiens_hsa052160.32993831
152Adipocytokine signaling pathway_Homo sapiens_hsa049200.32051715
153Alcoholism_Homo sapiens_hsa050340.31665298
154Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29124243
155Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28681594
156Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.28655813
157Glycosaminoglycan degradation_Homo sapiens_hsa005310.27917159
158Systemic lupus erythematosus_Homo sapiens_hsa053220.27385885
159Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.27220897
160Biosynthesis of amino acids_Homo sapiens_hsa012300.26982439
161Intestinal immune network for IgA production_Homo sapiens_hsa046720.26351545
162NF-kappa B signaling pathway_Homo sapiens_hsa040640.25650837
163mRNA surveillance pathway_Homo sapiens_hsa030150.24916162
164Pertussis_Homo sapiens_hsa051330.24035201
165Amphetamine addiction_Homo sapiens_hsa050310.23853489
166Morphine addiction_Homo sapiens_hsa050320.23328126
167Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.23097198
168Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.23018621
169Circadian entrainment_Homo sapiens_hsa047130.22761385
170Influenza A_Homo sapiens_hsa051640.22669196
171Allograft rejection_Homo sapiens_hsa053300.22546294
172Sphingolipid metabolism_Homo sapiens_hsa006000.19341812
173Cyanoamino acid metabolism_Homo sapiens_hsa004600.18847560
174Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.18532352

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