DOC2GP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell wall macromolecule catabolic process (GO:0016998)6.08323520
2cell wall macromolecule metabolic process (GO:0044036)4.96188920
3behavioral response to nicotine (GO:0035095)4.51715723
4positive regulation of CREB transcription factor activity (GO:0032793)4.28790534
5regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.25013880
6head development (GO:0060322)4.23408372
7positive regulation of antigen processing and presentation (GO:0002579)4.13366010
8response to pheromone (GO:0019236)4.11731692
9cell proliferation in forebrain (GO:0021846)4.10793566
10purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.87324405
11cilium or flagellum-dependent cell motility (GO:0001539)3.73353657
12viral transcription (GO:0019083)3.68475271
13establishment of protein localization to mitochondrial membrane (GO:0090151)3.66966325
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.66687652
15mitochondrion transport along microtubule (GO:0047497)3.65145224
16establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.65145224
17positive regulation of T cell apoptotic process (GO:0070234)3.61728374
18centriole replication (GO:0007099)3.59367651
19somite development (GO:0061053)3.56626867
20RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.52978519
21tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.52978519
22establishment of mitochondrion localization (GO:0051654)3.45026033
23purine deoxyribonucleotide metabolic process (GO:0009151)3.29302019
24translational termination (GO:0006415)3.28220906
25regulation of antigen processing and presentation (GO:0002577)3.26624565
26cellular response to ATP (GO:0071318)3.23061947
27ribosomal small subunit biogenesis (GO:0042274)3.16825802
28cell migration in hindbrain (GO:0021535)3.15929102
29negative regulation of organelle assembly (GO:1902116)3.14933996
30antigen processing and presentation via MHC class Ib (GO:0002475)3.13779401
31hypothalamus development (GO:0021854)3.12494230
32protein import into peroxisome matrix (GO:0016558)3.09189860
33negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.07397049
34regulation of DNA endoreduplication (GO:0032875)3.05811016
35DNA methylation involved in gamete generation (GO:0043046)3.05281440
36purinergic nucleotide receptor signaling pathway (GO:0035590)3.02459432
37spinal cord development (GO:0021510)3.00638664
38positive regulation of mast cell activation (GO:0033005)2.96655655
39regulation of chromatin binding (GO:0035561)2.95770638
40DNA alkylation (GO:0006305)2.91526222
41DNA methylation (GO:0006306)2.91526222
42genetic imprinting (GO:0071514)2.90767111
43mitochondrial DNA replication (GO:0006264)2.90671374
44negative thymic T cell selection (GO:0045060)2.89153143
45positive regulation of respiratory burst (GO:0060267)2.86105527
46negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.85824967
47meiotic chromosome segregation (GO:0045132)2.85575757
48activated T cell proliferation (GO:0050798)2.82490176
49NIK/NF-kappaB signaling (GO:0038061)2.81244677
50positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.80840968
51DNA double-strand break processing (GO:0000729)2.80568496
52intracellular protein transmembrane import (GO:0044743)2.80468763
53response to ATP (GO:0033198)2.80416676
54positive regulation of mast cell degranulation (GO:0043306)2.80019262
55positive regulation of mast cell activation involved in immune response (GO:0033008)2.80019262
56positive regulation of lymphocyte apoptotic process (GO:0070230)2.79230852
57regulation of gene expression by genetic imprinting (GO:0006349)2.78464053
58parturition (GO:0007567)2.77666631
59mRNA splice site selection (GO:0006376)2.77274290
60lateral sprouting from an epithelium (GO:0060601)2.76924725
61purine ribonucleotide transport (GO:0015868)2.76737836
62negative T cell selection (GO:0043383)2.76289945
63histone H2B ubiquitination (GO:0033523)2.74326870
64negative regulation of potassium ion transmembrane transport (GO:1901380)2.74002331
65RNA destabilization (GO:0050779)2.73669642
66protein targeting to peroxisome (GO:0006625)2.73628098
67establishment of protein localization to peroxisome (GO:0072663)2.73628098
68protein localization to peroxisome (GO:0072662)2.73628098
69adenine nucleotide transport (GO:0051503)2.72829001
70positive regulation of guanylate cyclase activity (GO:0031284)2.72800579
71pyrimidine nucleotide catabolic process (GO:0006244)2.71740574
72negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.69629849
73cellular response to exogenous dsRNA (GO:0071360)2.69624044
74positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.67698630
75translational elongation (GO:0006414)2.66557327
76pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.63136216
77neuronal stem cell maintenance (GO:0097150)2.60705895
78regulation of glycogen (starch) synthase activity (GO:2000465)2.60243566
79regulation of feeding behavior (GO:0060259)2.59809042
80snRNA transcription (GO:0009301)2.59062591
81positive regulation of neuroblast proliferation (GO:0002052)2.58892826
822-oxoglutarate metabolic process (GO:0006103)2.57880567
83endoderm formation (GO:0001706)2.56991721
84centriole assembly (GO:0098534)2.56095288
85urinary tract smooth muscle contraction (GO:0014848)2.55788402
86atrial cardiac muscle cell action potential (GO:0086014)2.54675516
87glycoprotein catabolic process (GO:0006516)2.54040282
88antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.53115950
89membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.52449009
90DNA replication checkpoint (GO:0000076)2.51936462
91purine deoxyribonucleotide catabolic process (GO:0009155)2.51064525
92cellular protein complex disassembly (GO:0043624)2.50516263
93negative regulation of neurotransmitter secretion (GO:0046929)2.49874621
94purinergic receptor signaling pathway (GO:0035587)2.49719250
95protein complex disassembly (GO:0043241)2.49409219
96tachykinin receptor signaling pathway (GO:0007217)2.48527858
97histone H3-K9 methylation (GO:0051567)2.48470022
98regulation of guanylate cyclase activity (GO:0031282)2.48052246
99antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.47315483
100axonemal dynein complex assembly (GO:0070286)2.47087870

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.62071328
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.58095525
3VDR_21846776_ChIP-Seq_THP-1_Human3.21990008
4MYC_22102868_ChIP-Seq_BL_Human2.77369783
5STAT6_21828071_ChIP-Seq_BEAS2B_Human2.67495431
6ELF1_17652178_ChIP-ChIP_JURKAT_Human2.65435939
7TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.63145003
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.46575174
9SCL_19346495_ChIP-Seq_HPC-7_Human2.46565925
10P68_20966046_ChIP-Seq_HELA_Human2.15467016
11IKZF1_21737484_ChIP-ChIP_HCT116_Human2.15463457
12BCL6_27268052_Chip-Seq_Bcells_Human2.13898024
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.13502226
14KDM2B_26808549_Chip-Seq_DND41_Human1.95911952
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.95069712
16CTCF_27219007_Chip-Seq_Bcells_Human1.93047478
17ERG_21242973_ChIP-ChIP_JURKAT_Human1.86459433
18MAF_26560356_Chip-Seq_TH2_Human1.85477068
19KDM2B_26808549_Chip-Seq_SUP-B15_Human1.84181429
20MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.84166550
21E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.83132593
22CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.82587414
23RARB_24833708_ChIP-Seq_LIVER_Mouse1.77086071
24LXR_22292898_ChIP-Seq_THP-1_Human1.74374475
25E2F1_20622854_ChIP-Seq_HELA_Human1.71164031
26TET1_21451524_ChIP-Seq_MESCs_Mouse1.68470976
27KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.68334956
28RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.65309627
29UTX_26944678_Chip-Seq_JUKART_Human1.64446816
30DROSHA_22980978_ChIP-Seq_HELA_Human1.62264471
31MAF_26560356_Chip-Seq_TH1_Human1.61273176
32CIITA_25753668_ChIP-Seq_RAJI_Human1.60892780
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59109736
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.58211072
35STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.56524923
36FOXP1_21924763_ChIP-Seq_HESCs_Human1.54904002
37MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.53992929
38GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.53915060
39ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.51945609
40EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.50549803
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.49898582
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.48719817
43PHF8_20622854_ChIP-Seq_HELA_Human1.45451965
44KDM2B_26808549_Chip-Seq_JURKAT_Human1.43034897
45VDR_24763502_ChIP-Seq_THP-1_Human1.41762192
46SMC4_20622854_ChIP-Seq_HELA_Human1.40166983
47KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.39538560
48REST_18959480_ChIP-ChIP_MESCs_Mouse1.39344696
49DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.38669121
50REST_21632747_ChIP-Seq_MESCs_Mouse1.36922295
51HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.35544819
52BCOR_27268052_Chip-Seq_Bcells_Human1.35066750
53TCF7_22412390_ChIP-Seq_EML_Mouse1.33221487
54MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.31801962
55ERA_21632823_ChIP-Seq_H3396_Human1.30901325
56YY1_22570637_ChIP-Seq_MALME-3M_Human1.30003134
57ELF1_20517297_ChIP-Seq_JURKAT_Human1.29478608
58SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.28168637
59SA1_27219007_Chip-Seq_Bcells_Human1.26487563
60IRF8_22096565_ChIP-ChIP_GC-B_Human1.26354901
61OCT4_19829295_ChIP-Seq_ESCs_Human1.26329616
62CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.25482183
63RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.22442353
64EZH2_27294783_Chip-Seq_ESCs_Mouse1.20690029
65HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.20345249
66PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.19277229
67ETS1_21867929_ChIP-Seq_TH2_Mouse1.18608582
68RUNX_20019798_ChIP-Seq_JUKART_Human1.18191732
69SUZ12_27294783_Chip-Seq_ESCs_Mouse1.17943582
70RAC3_21632823_ChIP-Seq_H3396_Human1.16440528
71SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.16325122
72SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15672844
73SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.15339234
74JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.15047241
75CTCF_26484167_Chip-Seq_Bcells_Mouse1.11399111
76TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10829663
77TAF2_19829295_ChIP-Seq_ESCs_Human1.10624546
78SPI1_23127762_ChIP-Seq_K562_Human1.10440766
79MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.10031357
80NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.09463227
81SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.08851460
82EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08673128
83SA1_27219007_Chip-Seq_ERYTHROID_Human1.08175777
84PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06829366
85LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.06017010
86IRF1_19129219_ChIP-ChIP_H3396_Human1.04201281
87GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.03608795
88OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.03361726
89RARA_24833708_ChIP-Seq_LIVER_Mouse1.02902748
90CTCF_21964334_ChIP-Seq_BJAB-B_Human1.02873444
91TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01839464
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01839464
93SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00222343
94XRN2_22483619_ChIP-Seq_HELA_Human0.99251366
95DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99095683
96RXRA_24833708_ChIP-Seq_LIVER_Mouse0.98533911
97PU.1_20513432_ChIP-Seq_Bcells_Mouse0.97155489
98KDM2B_26808549_Chip-Seq_K562_Human0.97025587
99FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96768010
100CTCF_27219007_Chip-Seq_ERYTHROID_Human0.96317687

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue6.41993420
2MP0002837_dystrophic_cardiac_calcinosis5.07094763
3MP0003787_abnormal_imprinting4.80263000
4MP0006292_abnormal_olfactory_placode4.23284603
5MP0004185_abnormal_adipocyte_glucose3.58453181
6MP0002653_abnormal_ependyma_morphology3.54054451
7MP0004130_abnormal_muscle_cell3.14754737
8MP0005423_abnormal_somatic_nervous2.80476989
9MP0004147_increased_porphyrin_level2.52928079
10MP0001986_abnormal_taste_sensitivity2.50249299
11MP0003172_abnormal_lysosome_physiology2.33382104
12MP0003121_genomic_imprinting2.09053214
13MP0001348_abnormal_lacrimal_gland2.07313734
14MP0003122_maternal_imprinting1.95931535
15MP0003136_yellow_coat_color1.85867113
16MP0003806_abnormal_nucleotide_metabolis1.82265372
17MP0002234_abnormal_pharynx_morphology1.80836865
18MP0005394_taste/olfaction_phenotype1.79045587
19MP0005499_abnormal_olfactory_system1.79045587
20MP0008775_abnormal_heart_ventricle1.76183985
21MP0002735_abnormal_chemical_nociception1.70522254
22MP0003137_abnormal_impulse_conducting1.61894158
23MP0000778_abnormal_nervous_system1.61217271
24MP0000372_irregular_coat_pigmentation1.60757262
25MP0008789_abnormal_olfactory_epithelium1.60709500
26MP0005666_abnormal_adipose_tissue1.44172822
27MP0004859_abnormal_synaptic_plasticity1.39776518
28MP0003878_abnormal_ear_physiology1.33368399
29MP0005377_hearing/vestibular/ear_phenot1.33368399
30MP0008877_abnormal_DNA_methylation1.26009930
31MP0005410_abnormal_fertilization1.25152619
32MP0004142_abnormal_muscle_tone1.24831755
33MP0000681_abnormal_thyroid_gland1.21788896
34MP0003436_decreased_susceptibility_to1.21635726
35MP0000631_abnormal_neuroendocrine_gland1.18724812
36MP0001800_abnormal_humoral_immune1.18705704
37MP0004133_heterotaxia1.16331843
38MP0003123_paternal_imprinting1.09562690
39MP0003763_abnormal_thymus_physiology1.09013685
40MP0005671_abnormal_response_to1.08950269
41MP0001968_abnormal_touch/_nociception1.08514570
42MP0005646_abnormal_pituitary_gland1.07094160
43MP0001485_abnormal_pinna_reflex1.06135628
44MP0000049_abnormal_middle_ear1.04428807
45MP0009053_abnormal_anal_canal1.03415589
46MP0002733_abnormal_thermal_nociception1.00921467
47MP0004145_abnormal_muscle_electrophysio1.00552299
48MP0001970_abnormal_pain_threshold0.98071908
49MP0000678_abnormal_parathyroid_gland0.96750599
50MP0003938_abnormal_ear_development0.96282335
51MP0004381_abnormal_hair_follicle0.95243192
52MP0001188_hyperpigmentation0.94511635
53MP0009278_abnormal_bone_marrow0.93464305
54MP0001835_abnormal_antigen_presentation0.93419754
55MP0001853_heart_inflammation0.92884244
56MP0002398_abnormal_bone_marrow0.90566972
57MP0002063_abnormal_learning/memory/cond0.89370954
58MP0000703_abnormal_thymus_morphology0.87636755
59MP0002723_abnormal_immune_serum0.85562193
60MP0002163_abnormal_gland_morphology0.83983539
61MP0002249_abnormal_larynx_morphology0.83881828
62MP0001661_extended_life_span0.82008798
63MP0002734_abnormal_mechanical_nocicepti0.81517525
64MP0000689_abnormal_spleen_morphology0.81506392
65MP0009115_abnormal_fat_cell0.80666435
66MP0003890_abnormal_embryonic-extraembry0.79750761
67MP0002420_abnormal_adaptive_immunity0.79681451
68MP0002928_abnormal_bile_duct0.79624857
69MP0000716_abnormal_immune_system0.79476290
70MP0008995_early_reproductive_senescence0.79211432
71MP0002132_abnormal_respiratory_system0.77905062
72MP0001819_abnormal_immune_cell0.77153456
73MP0010030_abnormal_orbit_morphology0.73409165
74MP0002429_abnormal_blood_cell0.72474927
75MP0009250_abnormal_appendicular_skeleto0.71994548
76MP0001502_abnormal_circadian_rhythm0.70817866
77MP0005387_immune_system_phenotype0.70655194
78MP0001790_abnormal_immune_system0.70655194
79MP0000955_abnormal_spinal_cord0.69975311
80MP0005535_abnormal_body_temperature0.69946337
81MP0006276_abnormal_autonomic_nervous0.68389740
82MP0002722_abnormal_immune_system0.67083088
83MP0009745_abnormal_behavioral_response0.66891325
84MP0008875_abnormal_xenobiotic_pharmacok0.65281955
85MP0010155_abnormal_intestine_physiology0.65231598
86MP0003866_abnormal_defecation0.64204436
87MP0001905_abnormal_dopamine_level0.63943912
88MP0002452_abnormal_antigen_presenting0.63515781
89MP0003329_amyloid_beta_deposits0.63234797
90MP0002822_catalepsy0.61904490
91MP0003959_abnormal_lean_body0.61350925
92MP0002572_abnormal_emotion/affect_behav0.60738167
93MP0005551_abnormal_eye_electrophysiolog0.59624814
94MP0005174_abnormal_tail_pigmentation0.57967313
95MP0002932_abnormal_joint_morphology0.57473708
96MP0001545_abnormal_hematopoietic_system0.57005575
97MP0005397_hematopoietic_system_phenotyp0.57005575
98MP0005000_abnormal_immune_tolerance0.56559102
99MP0005083_abnormal_biliary_tract0.56405913
100MP0002138_abnormal_hepatobiliary_system0.55141421

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.46887009
2Diastasis recti (HP:0001540)3.88458079
3Myokymia (HP:0002411)3.50381040
4Breast hypoplasia (HP:0003187)3.49669355
5Bile duct proliferation (HP:0001408)3.10718835
6Abnormal biliary tract physiology (HP:0012439)3.10718835
7Thin bony cortex (HP:0002753)3.08323616
8Patellar aplasia (HP:0006443)3.08114203
9Long foot (HP:0001833)3.08072151
10True hermaphroditism (HP:0010459)2.98467845
11Aplasia/Hypoplasia of the sternum (HP:0006714)2.91508296
12Type II lissencephaly (HP:0007260)2.90942561
13Aplasia/Hypoplasia of the patella (HP:0006498)2.85618367
14Microretrognathia (HP:0000308)2.81386624
15Pancreatic cysts (HP:0001737)2.80305784
16Abnormality of the costochondral junction (HP:0000919)2.79188696
17Progressive microcephaly (HP:0000253)2.72696706
18Abnormality of cells of the erythroid lineage (HP:0012130)2.66779121
19Chronic hepatic failure (HP:0100626)2.65023750
20Pancreatic fibrosis (HP:0100732)2.63977795
21Annular pancreas (HP:0001734)2.61133857
22Nephronophthisis (HP:0000090)2.57225877
23Congenital stationary night blindness (HP:0007642)2.54781256
24Rib fusion (HP:0000902)2.50835957
25Papilledema (HP:0001085)2.48546378
26Septo-optic dysplasia (HP:0100842)2.45215855
27Abnormal number of erythroid precursors (HP:0012131)2.44021267
28Acute hepatic failure (HP:0006554)2.43414279
29Neonatal respiratory distress (HP:0002643)2.43080713
30Patent foramen ovale (HP:0001655)2.33847543
31Delayed epiphyseal ossification (HP:0002663)2.31821097
32Panhypogammaglobulinemia (HP:0003139)2.30336385
33Hyperthyroidism (HP:0000836)2.30263200
34Obstructive sleep apnea (HP:0002870)2.29811224
35Type 2 muscle fiber atrophy (HP:0003554)2.26290116
36Abnormality of the proximal phalanges of the hand (HP:0009834)2.26147281
37Abnormality of the nasal septum (HP:0000419)2.25023428
38Absent phalangeal crease (HP:0006109)2.23835498
39Enlarged epiphyses (HP:0010580)2.23558317
40Slender long bone (HP:0003100)2.21526222
41Oligodactyly (hands) (HP:0001180)2.21293803
42Abnormality of the columella (HP:0009929)2.18905913
43Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.18846457
44Morphological abnormality of the middle ear (HP:0008609)2.15551952
45Muscle fiber atrophy (HP:0100295)2.13548246
46Cystic liver disease (HP:0006706)2.13184146
47Abnormality of the phalanges of the 5th finger (HP:0004213)2.09477686
48Spinal canal stenosis (HP:0003416)2.08657715
49Anencephaly (HP:0002323)2.05994557
50Pallor (HP:0000980)2.05562374
51Abnormality of the right ventricle (HP:0001707)2.04698141
52Abnormal finger flexion creases (HP:0006143)2.00110079
53Gastrointestinal infarctions (HP:0005244)1.98088354
54Colitis (HP:0002583)1.96843416
55Oligodactyly (HP:0012165)1.96611277
56Abnormality of the fingertips (HP:0001211)1.96456532
57Dyskinesia (HP:0100660)1.92821595
58Absent/shortened dynein arms (HP:0200106)1.91739537
59Dynein arm defect of respiratory motile cilia (HP:0012255)1.91739537
60Myotonia (HP:0002486)1.91086878
61Neoplasm of the adrenal cortex (HP:0100641)1.89447826
62Poor speech (HP:0002465)1.89193708
63Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.89191631
64Supernumerary bones of the axial skeleton (HP:0009144)1.85770312
65Basal cell carcinoma (HP:0002671)1.84374891
66Cerebral palsy (HP:0100021)1.82748427
67Mediastinal lymphadenopathy (HP:0100721)1.82593755
68Abnormality of the 4th metacarpal (HP:0010012)1.81001854
69Synostosis involving the elbow (HP:0003938)1.80358856
70Humeroradial synostosis (HP:0003041)1.80358856
71Polydipsia (HP:0001959)1.79173458
72Abnormal drinking behavior (HP:0030082)1.79173458
73Molar tooth sign on MRI (HP:0002419)1.77971876
74Abnormality of midbrain morphology (HP:0002418)1.77971876
75Stereotypic behavior (HP:0000733)1.76606112
76Optic nerve hypoplasia (HP:0000609)1.76510918
77Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.75858369
78Short 4th metacarpal (HP:0010044)1.75858369
79Bony spicule pigmentary retinopathy (HP:0007737)1.75814210
80Lissencephaly (HP:0001339)1.73753317
81Depressed nasal tip (HP:0000437)1.72960776
82Porencephaly (HP:0002132)1.72837731
83Decreased circulating renin level (HP:0003351)1.72142052
84Meningocele (HP:0002435)1.71811078
85Chest pain (HP:0100749)1.71755827
86Thoracic kyphosis (HP:0002942)1.71292541
87Thrombocytosis (HP:0001894)1.69699684
88Limb hypertonia (HP:0002509)1.69673392
89Testicular atrophy (HP:0000029)1.67266067
90Abnormality of cochlea (HP:0000375)1.66743342
91Hypoplasia of the maxilla (HP:0000327)1.65395703
92Brushfield spots (HP:0001088)1.64910844
93IgM deficiency (HP:0002850)1.64877769
94Abnormality of the renal medulla (HP:0100957)1.64874987
95Squamous cell carcinoma (HP:0002860)1.64780803
96Medial flaring of the eyebrow (HP:0010747)1.64623523
97Prolonged bleeding time (HP:0003010)1.64147441
98Aplasia/Hypoplasia of the spleen (HP:0010451)1.63312634
99Anophthalmia (HP:0000528)1.62606315
100Abnormality of DNA repair (HP:0003254)1.61421427

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.70763009
2BMPR1B3.55928941
3SIK23.40406364
4TLK13.04660583
5ZAK3.03877142
6CAMKK12.62719227
7MAP4K12.47271312
8NTRK22.31022500
9ERN12.12120413
10TNIK2.01827161
11ICK1.80926987
12EEF2K1.78481543
13ACVR1B1.71828239
14CDC71.70230125
15FRK1.67706299
16MUSK1.62032417
17BTK1.61153624
18NEK21.56411429
19STK161.51506235
20MAP3K71.45834473
21FES1.43824447
22MARK31.43020943
23TNK21.41713730
24PINK11.25877579
25MARK21.25632247
26DAPK21.24686284
27MAPK131.24633910
28CAMKK21.21202772
29DYRK21.13939687
30MAPK151.13050290
31WNK41.06261965
32FGFR21.05020779
33TYRO31.02890243
34CAMK1D1.01502077
35AKT30.98019410
36PHKG20.97884322
37PHKG10.97884322
38MAPKAPK30.97563502
39CASK0.96509796
40MAP2K40.93901095
41RPS6KA20.92182912
42GRK60.91471405
43MAP3K40.90830010
44BCKDK0.89667732
45RPS6KA60.85892929
46PRKCQ0.85808263
47SYK0.85570387
48BLK0.84791548
49PRKCH0.78863251
50ITK0.78195558
51HCK0.77401898
52GRK70.76145734
53TXK0.75695957
54MAP3K110.73323221
55MAPK120.72965235
56RPS6KL10.72119370
57RPS6KC10.72119370
58LCK0.72050677
59CDK40.70832305
60TAOK30.68930957
61MAP2K70.66871874
62MAP3K90.66821638
63SGK2230.66696994
64SGK4940.66696994
65CAMK10.66562405
66BRAF0.66371694
67CSF1R0.65754074
68STK110.65643087
69SMG10.65277721
70TRIB30.64239385
71RPS6KA10.63958032
72LYN0.60901663
73TRPM70.60343453
74TEC0.59821032
75NME10.59640197
76CAMK1G0.59017553
77CSK0.58847489
78CAMK40.58352457
79EPHA40.54142145
80MAPK110.53772673
81LRRK20.52521392
82SIK30.51912948
83NTRK30.51362610
84MAP2K20.50537925
85NLK0.50454320
86MAP3K100.49349378
87TGFBR10.47479805
88MAP3K130.44299579
89CHEK20.43686232
90PKN10.43413900
91SGK10.41362436
92JAK30.39722108
93SGK30.39684764
94PTK60.39511588
95FYN0.38374859
96HIPK20.35166156
97RPS6KA50.34758563
98PRKD20.33283985
99DYRK1B0.33147032
100SGK20.32966345

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041223.48379048
2Intestinal immune network for IgA production_Homo sapiens_hsa046723.11418552
3Ribosome_Homo sapiens_hsa030102.70619263
4Phototransduction_Homo sapiens_hsa047442.58044808
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.56654271
6Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.49802180
7Other glycan degradation_Homo sapiens_hsa005112.39851024
8Asthma_Homo sapiens_hsa053102.37170176
9Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.22395699
10Homologous recombination_Homo sapiens_hsa034402.18382293
11Type II diabetes mellitus_Homo sapiens_hsa049302.10548560
12Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.94497715
13Primary immunodeficiency_Homo sapiens_hsa053401.92722703
14Allograft rejection_Homo sapiens_hsa053301.89827719
15Graft-versus-host disease_Homo sapiens_hsa053321.88665120
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.83781527
17Autoimmune thyroid disease_Homo sapiens_hsa053201.82156024
18Notch signaling pathway_Homo sapiens_hsa043301.52768439
19Carbohydrate digestion and absorption_Homo sapiens_hsa049731.47321478
20Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.40894241
21Basal cell carcinoma_Homo sapiens_hsa052171.37494811
22Glycerolipid metabolism_Homo sapiens_hsa005611.36169827
23B cell receptor signaling pathway_Homo sapiens_hsa046621.30587842
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.23971486
25Glycerophospholipid metabolism_Homo sapiens_hsa005641.17415350
26Hematopoietic cell lineage_Homo sapiens_hsa046401.16987585
27Staphylococcus aureus infection_Homo sapiens_hsa051501.16505299
28Serotonergic synapse_Homo sapiens_hsa047261.14964561
29Cholinergic synapse_Homo sapiens_hsa047251.14201066
30Linoleic acid metabolism_Homo sapiens_hsa005911.10207194
31Chemokine signaling pathway_Homo sapiens_hsa040621.09746953
32Antigen processing and presentation_Homo sapiens_hsa046121.09292892
33T cell receptor signaling pathway_Homo sapiens_hsa046601.09273554
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.08089562
35VEGF signaling pathway_Homo sapiens_hsa043701.07746256
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.07373832
37Calcium signaling pathway_Homo sapiens_hsa040201.05547741
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.00012829
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.99468089
40Morphine addiction_Homo sapiens_hsa050320.98113558
41Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.97921032
42Systemic lupus erythematosus_Homo sapiens_hsa053220.97345909
43Insulin resistance_Homo sapiens_hsa049310.96442931
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.95390007
45Jak-STAT signaling pathway_Homo sapiens_hsa046300.94755461
46Hedgehog signaling pathway_Homo sapiens_hsa043400.92556297
47Adipocytokine signaling pathway_Homo sapiens_hsa049200.90285488
48Type I diabetes mellitus_Homo sapiens_hsa049400.88135985
49Acute myeloid leukemia_Homo sapiens_hsa052210.82899830
50Leishmaniasis_Homo sapiens_hsa051400.81493809
51Fanconi anemia pathway_Homo sapiens_hsa034600.81024041
52mTOR signaling pathway_Homo sapiens_hsa041500.77949172
53Non-small cell lung cancer_Homo sapiens_hsa052230.77075382
54Endometrial cancer_Homo sapiens_hsa052130.76327391
55Viral myocarditis_Homo sapiens_hsa054160.76062632
56Platelet activation_Homo sapiens_hsa046110.75509407
57Insulin secretion_Homo sapiens_hsa049110.74970035
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74164478
59Colorectal cancer_Homo sapiens_hsa052100.72316576
60Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69243131
61Nicotine addiction_Homo sapiens_hsa050330.69191225
62Alcoholism_Homo sapiens_hsa050340.67660195
63GABAergic synapse_Homo sapiens_hsa047270.67008875
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.66894090
65Oxytocin signaling pathway_Homo sapiens_hsa049210.66184678
66FoxO signaling pathway_Homo sapiens_hsa040680.65857247
67NOD-like receptor signaling pathway_Homo sapiens_hsa046210.64954245
68Ovarian steroidogenesis_Homo sapiens_hsa049130.64482548
69Circadian entrainment_Homo sapiens_hsa047130.61539474
70Glutamatergic synapse_Homo sapiens_hsa047240.59089219
71Inositol phosphate metabolism_Homo sapiens_hsa005620.58544698
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.58211538
73Tryptophan metabolism_Homo sapiens_hsa003800.57459787
74Long-term depression_Homo sapiens_hsa047300.57097967
75cAMP signaling pathway_Homo sapiens_hsa040240.54983008
76Base excision repair_Homo sapiens_hsa034100.52476955
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50834200
78Herpes simplex infection_Homo sapiens_hsa051680.49893111
79Arachidonic acid metabolism_Homo sapiens_hsa005900.49435170
80Taste transduction_Homo sapiens_hsa047420.48978258
81Regulation of autophagy_Homo sapiens_hsa041400.47250851
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47209457
83Lysine degradation_Homo sapiens_hsa003100.46577720
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45625299
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45472746
86Amphetamine addiction_Homo sapiens_hsa050310.44823394
87Dorso-ventral axis formation_Homo sapiens_hsa043200.44195934
88HTLV-I infection_Homo sapiens_hsa051660.43901749
89AMPK signaling pathway_Homo sapiens_hsa041520.43622629
90GnRH signaling pathway_Homo sapiens_hsa049120.42931537
91Cardiac muscle contraction_Homo sapiens_hsa042600.42574723
92MAPK signaling pathway_Homo sapiens_hsa040100.39748441
93Tuberculosis_Homo sapiens_hsa051520.38866844
94NF-kappa B signaling pathway_Homo sapiens_hsa040640.35385817
95Melanogenesis_Homo sapiens_hsa049160.35074631
96Thyroid hormone synthesis_Homo sapiens_hsa049180.34762592
97Dopaminergic synapse_Homo sapiens_hsa047280.33697420
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32659572
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30827707
100Ras signaling pathway_Homo sapiens_hsa040140.30473267

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